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SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

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Рисунок 1. Взаимосвязь патентов (ближайшие 20).

Bcl-2 inhibitors and their use as pharmaceuticals

Номер патента: US20210346405A1. Автор: Peng Wei,Jincong Zhuo,Jialiang Wang,Andrew Paul Combs. Владелец: Prelude Therapeutics Inc. Дата публикации: 2021-11-11.

CDK Inhibitors And Their Use As Pharmaceuticals

Номер патента: US20230234964A1. Автор: Xiaowei Wu,Jincong Zhuo,Katarina ROHLFING,Andrew Combs. Владелец: Prelude Therapeutics Inc. Дата публикации: 2023-07-27.

CDK Inhibitors And Their Use As Pharmaceuticals

Номер патента: US20240246993A1. Автор: Xiaowei Wu,Jincong Zhuo,Katarina ROHLFING,Andrew Combs. Владелец: Prelude Therapeutics Inc. Дата публикации: 2024-07-25.

Diazine-fused amidines as BACE inhibitors, compositions, and their use

Номер патента: US09868738B2. Автор: Kun Liu,Andrew W. Stamford,Jared N. Cumming,Shuwen He. Владелец: Merck Sharp and Dohme LLC. Дата публикации: 2018-01-16.

Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors

Номер патента: US11866445B2. Автор: Jens Larsen. Владелец: Union Therapeutics AS. Дата публикации: 2024-01-09.

.beta.-carboline derivatives useful as inhibitors of phosphodiesterase

Номер патента: CA2409715C. Автор: Zhihua Sui,Mark J. Macielag. Владелец: Ortho McNeil Pharmaceutical Inc. Дата публикации: 2010-09-14.

Cdk inhibitors and their use as pharmaceuticals

Номер патента: WO2024216249A1. Автор: Xiaowei Wu,Andrew Combs. Владелец: Prelude Therapeutics Incorporated. Дата публикации: 2024-10-17.

CDK inhibitors and their use as pharmaceuticals

Номер патента: US12129262B2. Автор: Xiaowei Wu,Andrew W. Buesking,Katarina ROHLFING,Andrew Paul Combs,Ryan Holmes,Sarah Pawley. Владелец: Prelude Therapeutics Inc. Дата публикации: 2024-10-29.

Czclic amide derivatives, and their production and use as entithrombotic agents

Номер патента: RS51925B. Автор: K. Kubo,Y. Imaeda. Владелец: Takeda Pharmaceutical Company Limited. Дата публикации: 2012-02-29.

Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors

Номер патента: US9102619B2. Автор: Elisabetta Armani,Maurizio Delcanale,Gabriele Amari. Владелец: Chiesi Farmaceutici SpA. Дата публикации: 2015-08-11.

Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors

Номер патента: US9000177B2. Автор: Elisabetta Armani,Maurizio Delcanale,Gabriele Amari. Владелец: Chiesi Farmaceutici SpA. Дата публикации: 2015-04-07.

Selective HDAC8 inhibitors and their uses

Номер патента: US11801251B2. Автор: Franz-Josef Meyer-Almes,Christian MEYNERS,Alexander KLEINSCHEK,Patricia HAUS. Владелец: Hochschule Darmstadt. Дата публикации: 2023-10-31.

Selective hdac8 inhibitors and their uses

Номер патента: EP3371195A1. Автор: Franz-Josef Meyer-Almes,Christian MEYNERS,Alexander KLEINSCHEK,Patricia HAUS. Владелец: Hochschule Darmstadt. Дата публикации: 2018-09-12.

HDAC6 inhibitors, with improved solubility and their uses

Номер патента: US11198694B2. Автор: Siavosh Mahboobi,Herwig Pongratz,Elisabeth Grünstein. Владелец: UNIVERSITAET REGENSBURG. Дата публикации: 2021-12-14.

C5-spiro iminothiazine dioxides as BACE inhibitors, compositions, and their use

Номер патента: US09725468B2. Автор: Jared N. Cumming,Jack D. Scott,Wen-Lian Wu. Владелец: Merck Sharp and Dohme LLC. Дата публикации: 2017-08-08.

Thaizole-pyrimdiine cdk inhibitors and their use as pharmaceuticals

Номер патента: WO2023172957A1. Автор: Jincong Zhuo,Andrew Combs. Владелец: Prelude Therapeutics, Incorporated. Дата публикации: 2023-09-14.

Novel oxazine derivatives and their use in the treatment of disease

Номер патента: US20130172331A1. Автор: Rainer Martin Lueoend,Rainer Machauer,Heinrich Rueeger,Siem Jacob Veenstra. Владелец: NOVARTIS AG. Дата публикации: 2013-07-04.

Compounds and their uses as cd38 inhibitors

Номер патента: US20240254113A1. Автор: Kin Chiu Fong,Jianfei Wang,Guohuang Fan,Jianbei XI. Владелец: Nanjing Immunophage Biotech Co Ltd. Дата публикации: 2024-08-01.

Novel heterocyclic derivatives useful as shp2 inhibitors

Номер патента: US20240285617A1. Автор: Cunbo Ma,Panliang Gao,Di Kang,Huifeng Han. Владелец: Jacobio Pharmaceuticals Co Ltd. Дата публикации: 2024-08-29.

Heterocyclic derivatives useful as shp2 inhibitors

Номер патента: US20240245681A1. Автор: Cunbo Ma,Panliang Gao,Di Kang,Huifeng Han. Владелец: Jacobo Pharmaceuticats Co Ltd. Дата публикации: 2024-07-25.

Photo-switchable sulfonylureas and their uses

Номер патента: WO2016059093A1. Автор: David Hodson,Dirk Trauner,Johannes BROICHHAGEN,Guy Rutter. Владелец: LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN. Дата публикации: 2016-04-21.

N-substituted phenylalkylamines and their use as therapeutic agents

Номер патента: WO2024006226A1. Автор: Paul Daley,Nicholas COZZI. Владелец: Alexander Shulgin Research Institute, Inc.. Дата публикации: 2024-01-04.

Compounds useful as antiproliferative agents and garft inhibitors

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8.alpha.-acylamino ergolines, their production and use as drugs

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New thiazole derivatives and their addition salts used as couplers in hair dye compositions

Номер патента: FR2857664A1. Автор: Laurent Vidal,Jean Baptiste Saunier,Jacqueline Mavro. Владелец: LOreal SA. Дата публикации: 2005-01-21.

Novel phosphodiesterase inhibitors

Номер патента: CA2676933C. Автор: Bollu Ravindra Babu,Jakob Felding,Simon Feldbaek Nielsen,Jens Christian Hojland Larsen. Владелец: Leo Pharma AS. Дата публикации: 2015-09-29.

Bicyclopolyazamacrocyclophosphonic acid complexes,a process for their preparation,and their conjugates,for use as radiopharmaceuticals

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Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors

Номер патента: EP1448562A1. Автор: Zhihua Sui,Weiqin Jiang. Владелец: Ortho McNeil Pharmaceutical Inc. Дата публикации: 2004-08-25.

Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors

Номер патента: US20030144268A1. Автор: Zhihua Sui,Weiqin Jiang. Владелец: Ortho McNeil Pharmaceutical Inc. Дата публикации: 2003-07-31.

Alpha helical mimics, their uses and methods for their production

Номер патента: EP1737884A1. Автор: David P. Fairlie,Nicholas E. Shepherd. Владелец: University of Queensland UQ. Дата публикации: 2007-01-03.

7-/alpha-(2-oxo-imidazolidin-1-yl-carbonylamino)phenylacetamido/-cephalosporins,processes for their preparation and their use as medicaments

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New phloroglucinol derivatives,their method of preparation and their use as pharmaceuticals

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Compounds and their uses as gpr183 inhibitors

Номер патента: EP4419511A1. Автор: Jianfei Wang,Guohuang Fan,Jianbei XI. Владелец: Nanjing Immunophage Biotech Co Ltd. Дата публикации: 2024-08-28.

Compounds and their uses as gpr183 inhibitors

Номер патента: WO2024208303A1. Автор: Yue Li,Jianfei Wang,Guohuang Fan. Владелец: Nanjing Immunophage Biotech Co., Ltd. Дата публикации: 2024-10-10.

S-imino-S-oxo iminothiazine compounds as bace inhibitors, compositions, and their use

Номер патента: US09957269B2. Автор: Jared N. Cumming,Jack D. Scott. Владелец: Merck Sharp and Dohme LLC. Дата публикации: 2018-05-01.

Aza-bicycloalkyl ethers and their use as alpha7-nachr agonists

Номер патента: US09849117B2. Автор: Dominik Feuerbach,Konstanze Hurth,Timothy John Ritchie,Rochdi Bouhelal. Владелец: NOVARTIS AG. Дата публикации: 2017-12-26.

Aza-bicyloalkyl ethers and their use as alpha7-nachr agonists

Номер патента: US09567343B2. Автор: Dominik Feuerbach,Konstanze Hurth,Timothy John Ritchie,Rochdi Bouhelal. Владелец: NOVARTIS AG. Дата публикации: 2017-02-14.

Benzoisoindole derivatives and their use as ep4 receptor agonists

Номер патента: WO2008061955A1. Автор: Mark Patrick Healy,Gerard Martin Paul Giblin,Helen Susanne Price. Владелец: Glaxo Group Limited. Дата публикации: 2008-05-29.

Benzo[b]pyrrolo[3,2,1-jk]benzodiazepines, a process and¹intermediates for their preparation and their use as¹medicaments

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Quinazoline derivatives and their use as DNA methyltransferase inhibitors

Номер патента: US09951044B2. Автор: Paola Barbara Arimondo,Ludovic Halby. Владелец: Pierre Fabre Medicament SA. Дата публикации: 2018-04-24.

Phosphodiesterase inhibitors

Номер патента: WO2008035316A3. Автор: Sarala Balachandran,Venkata P Palle,Nidhi Gupta,Sunanda G Dastidar,Sonali Rudra,Vinayak Vasantrao Khairnar. Владелец: Vinayak Vasantrao Khairnar. Дата публикации: 2008-11-27.

Novel thioxanthine derivatives for use as inhibitors of mpo

Номер патента: WO2005037835A1. Автор: Anna-Karin Tiden,Anthony Kettle. Владелец: AstraZeneca AB. Дата публикации: 2005-04-28.

Compounds and their uses as gpr17 antagonists

Номер патента: WO2024153233A1. Автор: Yue Li,Yong Wu,Jianfei Wang,Guohuang Fan,Jilin JIA,Jianbei XI. Владелец: Nanjing Immunophage Biotech Co., Ltd. Дата публикации: 2024-07-25.

Novel thioxanthine derivatives for use as inhibitors of mpo

Номер патента: EP1678179A1. Автор: Anthony c/o Free Radical Research Group KETTLE,Anna-Karin TIDEN. Владелец: AstraZeneca AB. Дата публикации: 2006-07-12.

New picolinic acid derivatives and their use as intermediates

Номер патента: US20190345107A1. Автор: Thomas Heinz,Florian Andreas Rampf,Benjamin Martin,Werner Zaugg. Владелец: NOVARTIS AG. Дата публикации: 2019-11-14.

New picolinic acid derivatives and their use as intermediates

Номер патента: EP3555048A1. Автор: Thomas Heinz,Florian Andreas Rampf,Benjamin Martin,Werner Zaugg. Владелец: NOVARTIS AG. Дата публикации: 2019-10-23.

CDK Inhibitors And Their Use As Pharmaceuticals

Номер патента: US20240352029A1. Автор: Xiaowei Wu,Andrew Combs. Владелец: Prelude Therapeutics Inc. Дата публикации: 2024-10-24.

Cdk inhibitors and their use as pharmaceuticals

Номер патента: AU2021345423A9. Автор: Xiaowei Wu,Andrew W. Buesking,Jincong Zhuo,Andrew Paul Combs,Ryan Holmes,Sarah Pawley. Владелец: Prelude Therapeutics Inc. Дата публикации: 2024-10-24.

Pyrazolopyrimidines and their uses as pdgfr inhibitors

Номер патента: US20240360134A1. Автор: Zhijie Liu,Tianbao Lu,David BAUMAN. Владелец: ACTELION PHARMACEUTICALS LTD. Дата публикации: 2024-10-31.

Heterocyclic compounds and methods of their use

Номер патента: US09714224B2. Автор: Alan Naylor,Thomas David Mccarthy. Владелец: NOVARTIS AG. Дата публикации: 2017-07-25.

Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors

Номер патента: US09669015B2. Автор: Hesheng Zhang. Владелец: Tianjin Hemay Biotechnology Co Ltd. Дата публикации: 2017-06-06.

Pyrazole derivatives and their use as LPAR5 antagonists

Номер патента: US09346762B2. Автор: Marc Nazaré,Detlef Kozian,Andreas Evers,Werngard Czechtizky. Владелец: SANOFI SA. Дата публикации: 2016-05-24.

Thiazolopyrimidines and their use as modulators of chemokine receptor activity

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Porphyrin derivates and their use as photosensitizers in photodynamic therapy

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Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease

Номер патента: US09714249B2. Автор: Vito Guagnano,Heinrich Rueeger,Jutta Blank,Simona Cotesta. Владелец: NOVARTIS AG. Дата публикации: 2017-07-25.

Novel derivatives and their use as selective inhibitors of caspase-2

Номер патента: EP3433243A1. Автор: Etienne Jacotot. Владелец: Universite Paris Diderot Paris 7. Дата публикации: 2019-01-30.

Novel compounds and their use as selective inhibitors of caspase-2

Номер патента: US20200317647A1. Автор: Etienne Jacotot,Elodie BOSC. Владелец: Individual. Дата публикации: 2020-10-08.

Novel compounds and their use as selective inhibitors of caspase-2

Номер патента: US20230008495A1. Автор: Etienne Jacotot,Elodie BOSC. Владелец: Individual. Дата публикации: 2023-01-12.

Novel compounds and their use as selective inhibitors of caspase-2

Номер патента: EP3688019A1. Автор: Etienne Jacotot,Elodie BOSC. Владелец: Université de Paris. Дата публикации: 2020-08-05.

Manganese chelates and their use as contrast agents in magnetic resonance imaging (MRI)

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Substituted diketopiperazines and their use as oxytocin antagonists

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Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection

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Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection

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Analogs of indole-3-carbinol and their use as agents against infection

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Dihydrochalcone derivatives and their use as antibiotic agents

Номер патента: EP2890689A1. Автор: Francois Simard,André Pichette,Jean Legault. Владелец: Universite du Quebec a Chicoutimi UQAC. Дата публикации: 2015-07-08.

Dihydrochalcone derivatives and their use as antibiotic agents

Номер патента: US20150210663A1. Автор: Francois Simard,André Pichette,Jean Legault. Владелец: Universite du Quebec a Chicoutimi UQAC. Дата публикации: 2015-07-30.

Dihydrochalcone derivatives and their use as antibiotic agents

Номер патента: US9499509B2. Автор: Francois Simard,André Pichette,Jean Legault. Владелец: Universite du Quebec a Chicoutimi UQAC. Дата публикации: 2016-11-22.

Dihydrochalcone derivatives and their use as antibiotic agents

Номер патента: WO2014032183A1. Автор: Francois Simard,André Pichette,Jean Legault. Владелец: UNIVERSITE DU QUEBEC A CHICOUTIMI. Дата публикации: 2014-03-06.

Dihydrochalcone derivatives and their use as antibiotic agents

Номер патента: CA2883997C. Автор: Francois Simard,André Pichette,Jean Legault. Владелец: Universite du Quebec a Chicoutimi UQAC. Дата публикации: 2021-02-16.

Dihydrochalcone derivatives and their use as antibiotic agents

Номер патента: US09499509B2. Автор: Francois Simard,André Pichette,Jean Legault. Владелец: Universite du Quebec a Chicoutimi UQAC. Дата публикации: 2016-11-22.

Compounds and their uses for treating neurodegenerative disease

Номер патента: WO2023039010A1. Автор: Jim-Min Fang,Yu-Ling Tseng,Yi-Juang Chern,Yung-An Huang,Jen-Tse Joseph HUANG. Владелец: Liu, Fu-Tong. Дата публикации: 2023-03-16.

N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists

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N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists

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Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents

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5-membered heteroaryl derivatives used as sphingosine 1- phosphate receptor agonists

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Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents

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Pyrazolo[1,5-a]pyridine derivatives and methods of their use

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Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer

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Benzo-fused heterocyclic derivatives useful as agonists of GPR120

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Benzamide derivative useful as FASN inhibitors for the treatment of cancer

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Isoxazoline compositions and their use as antiparasitics

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Derivatives of swainsonine, processes for their preparation and their use as therapeutic agents

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Diphenylpyrazole compounds and their use

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Pyridoxamine chelating compounds manganese (II) chelates and their use as NMRI contrast agents

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Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses

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Pleuromutilin derivatives process for their preparation and their use

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Diphenyl-triazole derivatives and their use as anti-gestative, immuno-suppressant and anti-tumoral agents

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Novel heterocyclic compounds and their use

Номер патента: CA3215457A1. Автор: Ville Takio. Владелец: Equinorm Ltd. Дата публикации: 2022-10-06.

Heterocyclic compounds and their use

Номер патента: EP4313985A2. Автор: Ville Takio. Владелец: Equinorm Ltd. Дата публикации: 2024-02-07.

Cyclohexyl Amide Derivatives and Their Use as CRF-1 Receptor Antagonists

Номер патента: US20140088105A1. Автор: David Beattie,Andrew James Culshaw,Lisa Rooney,Emily Stanley. Владелец: NOVARTIS AG. Дата публикации: 2014-03-27.

THIAZOLOPYRIMIDINES USEFUL AS TNFα INHIBITORS

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INTEGRIN αIIbβ3 ACTIVATING PEPTIDES AND THEIR USE

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Novel heterocyclic compounds and their use

Номер патента: US20240246965A1. Автор: Ville Takio. Владелец: Equinorm Ltd. Дата публикации: 2024-07-25.

Indazole derivatives useful as glucagon receptor antagonists

Номер патента: US10774048B2. Автор: Rui Zhang,Tianbao Lu,Shyh-Ming Yang,Guozhang Xu,Micheal Gaul,Fengbin Song. Владелец: Janssen Pharmaceutica NV. Дата публикации: 2020-09-15.

Indazole derivatives useful as glucagon receptor antagonists

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