Antiarrhythmic and beta-blocking indole derivs - 4-(2-acetoxy-3-isopropylamino propoxy) indole and 4-(3-isopropylamino-2-(1-methylcyclohexyl-carbonyloxy) propoxy)indole
Реферат: New 4-(2-acetoxy-3-isopropylamino-propoxy)indole (I) and 4- 3-isopropylamino-2-(1-methylcyclohexyl-carbonyloxy)-propoxy indole and their acid addn salts are prepd. by acylation of 4-(2-hydroxy-3-isopropylaminopropoxy) indole (II) with acetic anhydride or 1-methyl-1-cyclohexane carboxylic acid anhydride in the presence of the corresp. acids, and recovering the product as the base or acid addn. salt. In an example, 12.4g (II) were suspended in 50 ml acetic acid and, after 10 ml. acetic anhydride had been added, stirred for 16 hrs. at room temp. 250 g ice were added and the product made alkaline with aqs. ammonia. The reaction mixt. was extracted with ether and the extract dried over MgSO4 at low pressure. Cpd. (I) cyclohexylsulphamate crystallised from methanol/ether as fine needles, m.p. 158-159 degrees C.
Indole derivatives containing acetylene group as ppar activators
Номер патента: RU2387639C2. Автор: Иоганнес ЭБИ,Жан АККЕРМАНН,Альфред БИНДЖЕЛИ,Уве ГРЕТЕР,Бернд КУН,Ханс-Петер МЭРКИ,Маркус МЕЙЕР. Владелец: Ф.Хоффманн-Ля Рош Аг. Дата публикации: 2010-04-27.