Реферат: 1,234,490. Trifluoromethylquinoline derivatives. ROUSSEL UCLAF. 20 Aug., 1969 [8 Nov., 1968], No. 41596/69. Heading C2C. Novel compounds of formula and acid addition salts thereof wherein n is 1 or 2 and R is a saturated or unsaturated heterocyclic radical containing an oxygen atom and/or nitrogen atom as hetero atom or atoms are prepared by transesterification of the corresponding C 1-4 alkyl ester and an alcohol HO(CH 2 ) n R. Ethyl o - trifluoromethylanilinomethylene malonate, prepared by action of o-trifluoromethylaniline on ethyl ethoxymethylenemalonate, is cyclized to give 3 - carbethoxy - 4 - hydroxy 8 - trifluoromethylquinoline which is hydrolysed to the free acid and decarboxylated to give 4- hydroxy - 8 - trifluoromethylquinoline which is halogenated to give the 4 - chloro compound which is reacted with methyl anthranilate to give 4 - (2<SP>1</SP> - methoxycarbonyl) - phenylamino - 8- trifluoromethylquinoline. Pharmaceutical compositions in conventional forms for oral, rectal, topical and parenteral administration and having anti-inflammatory and analgesic properties comprise an above novel compound and a carrier therefor.