Heterocyclic 5-membered and bicyclic amides as rock inhibitors.
Номер патента: CL2019003747A1
Опубликовано: 15-05-2020
Автор(ы): De Lucca Indawati, Kumar Maishal Tarun, Ladziata Vladimir, O Tora George, Tangirala Raghuram, Thiyagarajan Kamalraj, W Glunz Peter
Принадлежит: Bristol Myers Squibb Co
Опубликовано: 15-05-2020
Автор(ы): De Lucca Indawati, Kumar Maishal Tarun, Ladziata Vladimir, O Tora George, Tangirala Raghuram, Thiyagarajan Kamalraj, W Glunz Peter
Принадлежит: Bristol Myers Squibb Co
Реферат: LA PRESENTE INVENCIÓN PROPORCONA COMPUESTOS DE LA FÓRMULA (1), O SUS ESTEREOISÓMEROS, TAUTÓMEROS O SALES FARMACÉUTICAMENTE ACEPTABLES, EN DONDE TODAS LAS VARIABLES SON COMO SE DEFINEN EN LA PRESENTE. ESTOS COMPUESTOS SON INHIBIDORES SELECTIVOS DE ROCK. ESTA INVENCI3N TAMBIÉN SE REFIERE A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN ESTOS COMPUESTOS Y MÉTOCOS DE TRATAMIENTO DE TRASTORNOS CARDIOVASCULARES, DE LA MUSCULATURA LISA, ONCOLÓGICOS, NEUROPATOLÓGICOS, AUTOINMUNES, FIBRÓTICOS YÍO INFLAMATORIOS QUE LOS USAN. THE PRESENT INVENTION PROVIDES COMPOUNDS OF THE FORMULA (1), OR THEIR STEREOISOMERS, TAUTOMERS OR PHARMACEUTICALLY ACCEPTABLE SALTS, WHERE ALL THE VARIABLES ARE AS DEFINED HEREIN. THESE COMPOUNDS ARE SELECTIVE ROCK INHIBITORS. THIS INVENTION ALSO REFERS TO PHARMACEUTICAL COMPOSITIONS INCLUDING THESE COMPOUNDS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS, OF THE SMOOTH MUSCULATURE, ONCOLOGICAL, NEUROPATHOLOGICAL, INFLUENTIOUS, AUTOINMUNATORY, INFINMUNATORY, AUTOINMUNATORY AND FAMILY USERS.
5-membered and bicyclic heterocyclic amides as ROCK inhibitors
Номер патента: CN110869363A. Автор: R·坦吉拉拉,K·泰亚加拉简,P·W·格伦茨,V·拉德基塔,I·德卢卡,G·O·托拉,T·K·玛莎勒. Владелец: Bristol Myers Squibb Co. Дата публикации: 2020-03-06.