Industrial synthesis of serinol
Номер патента: EP4313934A1
Опубликовано: 07-02-2024
Автор(ы): Camilla Cavallotti, Giovanni Battista Giovenzana, Ivan MENEGOTTO, Luciano Lattuada
Принадлежит: BRACCO IMAGING SPA
Опубликовано: 07-02-2024
Автор(ы): Camilla Cavallotti, Giovanni Battista Giovenzana, Ivan MENEGOTTO, Luciano Lattuada
Принадлежит: BRACCO IMAGING SPA
Реферат: The present invention is related to the synthesis of 4-hydroxymethyl-2-oxazolidinone (serinol carbamate, SC), which can be subsequently hydrolyzed to 2-amino-1,3-propanediol (serinol), by reacting glycerol and urea: (I) In general, glycerol is heated with urea and a catalyst, with or without a solvent, to give mainly 4-hydroxymethyl-2-oxazolidinone (serinol carbamate, SC), which is hydrolyzed in the next step to 2-amino-1,3-propanediol (serinol). Alternatively, glycerol 1,2-carbonate can be used instead of glycerol. Serinol obtained by the process of the invention may be used in the synthesis of Iopamidol.
Industrial synthesis of serinol
Номер патента: US20240199530A1. Автор: Luciano Lattuada,Giovanni Battista Giovenzana,Camilla Cavallotti,Ivan MENEGOTTO. Владелец: BRACCO IMAGING SPA. Дата публикации: 2024-06-20.