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Maytansine-antibody conjugates and methods of using same

Номер патента: EP4313009A1
Опубликовано: 07-02-2024
Автор(ы): Edward H. HA, Leonard G. Presta, Manish HUDLIKAR, Paul A. JAMINET, Robert Lutz, Shou-Ching S. JAMINET
Принадлежит: Angiex Inc

Реферат: Antibody-drug conjugates (ADCs) are described, comprising anti-TM4SF1 antibodies, antigenbinding fragments thereof, a linker and a drug. The drug is an inhibitor of tubulin polymerization. Methods of use of the ADCs are also described.

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Polishing material for polishing hard surfaces, media including the material, and methods of forming and using same

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Expression vector for animal cells including CSP-B 5′-SAR factor and method for producing recombinant proteins using same

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Novel thermally stable fructose-6-phosphate-3-epimerase and a method of producing allulose using same

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Mob'-DERIVED RSF1010 PLASMID CONTAINING NO ANTIBIOTIC-RESISTANCE GENES, BACTERIUM CONTAINING SUCH PLASMID AND METHOD FOR PRODUCTION OF USEFUL METABOLITES

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Polyester film, preparation method thereof and method for reproducing polyethyleneterephthalate container using same

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Method for preparing catalyst for steam reforming of sulfur-containing methane gas, and method for preparing hydrogen by using same

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Escherichia species microorganism having l-tryptophan production capacity and method for producing l-tryptophan using same

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Composition for manufacturing polyurethane foam with a low content of a volatile organic compound, and a method of manufacturing polyurethane using same

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Below grade, blind side, waterproofing sheet membrane with adhesive and high reflectivity granular particle layer to fully bond to concrete/shotcrete, and a method of making, and using same

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Protein kinase allostery sensor and methods of making and using same

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Dual lap high strength adhesive for sheet membrane application, having reflectivity granular particle layer to fully bond to concrete/shotcrete, and a method of making, and using same

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Curable silicone compositions, electrically conductive silicone adhesives, methods of making and using same, and electrical devices containing same

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Modified microorganisms and methods of making butadiene using same

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Inkjet printing apparatus and method for inspecting inkjet head using same

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Hyaloclastite pozzolan, hyaloclastite based cement, hyaloclastite based concrete and method of making and using same

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Hyaloclastite pozzolan, hyaloclastite based cement, hyaloclastite based concrete and method of making and using same

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Composition for etching and method for manufacturing semiconductor device using same

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Composition for etching and method for manufacturing semiconductor device using same

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Composition for etching and method for manufacturing semiconductor device using same

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Composition for etching and method for manufacturing semiconductor device using same

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Composition for etching and method for manufacturing semiconductor device using same

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Biogenic activated carbon and methods of making and using same

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Biogenic activated carbon and methods of making and using same

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Biogenic activated carbon and methods of making and using same

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Compositions and articles including perfluoropolyether bottlebrush polymers and methods of making and using same

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Compositions and articles including perfluoropolyether bottlebrush polymers and methods of making and using same

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Ozone generating electrode, method of manufacturing same, and method of producing ozone using same

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Managed ecosystem utilizing produced water from oil and/or gas recovery operations and method for sequestering carbon dioxide using same

Номер патента: US20230233993A1. Автор: Donnie DURGADEEN,Yousef M. DARDAS,Hessah M. MOOSA. Владелец: Saudi Arabian Oil Co. Дата публикации: 2023-07-27.

O-succinylhomoserine producing microorganism and method for producing o-succinylhomoserine using same

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Reactive solvent-free adhesive composition and method of manufacturing tire using same

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Systems for the detection of targeted gene variations and viral genomes and methods of producing and using same

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Oligonucleotides for detecting lactobacillus and method for detecting lactobacillus by using same

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Oligonucleotides for detecting Lactobacillus and method for detecting Lactobacillus by using same

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Fuel additives, fuels, methods of making and using same

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Fuel additives, fuels, methods of making and using same

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Continuity compositions and methods of making and using same

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Nonwoven fibrous webs containing chemically active particulates and methods of making and using same

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Low viscosity kraft fibre having higher carboxyl content and methods of making and using same

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Water soluble film, packets employing the film, and methods of making and using same

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Salt block product and method of making and using same

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Polymer-supported electrodes containing multi-atomic clusters and methods of making and using same

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Carbon mineralization using hyaloclastite, volcanic ash or pumice pozzolan, cement and concrete using same and method of making and using same

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Polypeptides having hydrolytic activity on 1-kestose in the presence of sucrose but lacking sucrase (invertase) activity, polynucleotides encoding same and methods of producting and using same in industrial sucrose production from 1-kestose

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Carbon mineralization using hyaloclastite, volcanic ash and pumice mineral and an alkaline solution, cement and concrete using same and method of making and using same

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Self-foaming hot melt adhesive compositions and methods of making and using same

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Abrasive composites having a controlled rate of erosion, articles incorporating same, and methods of making and using same

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Self-foaming hot melt adhesive composition and methods of making and using same

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Waste separator scrap oil extraction device and method of producing recyclate using same

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Laser-induced graphene filters and methods of making and using same

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Cement additive for retardation of cement hydration, cement mixtures including same, and methods of forming and using same

Номер патента: EP4313177A1. Автор: Xu Chen,Wilfred V. Srubar, III. Владелец: University of Colorado. Дата публикации: 2024-02-07.

Aromatization catalyst and methods of making and using same

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Composition for inducing dedifferentiation from somatic cells to induced pluripotent stem cells and method of inducing dedifferentiation using same

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Porous polymeric carbon sorbents for direct air capture of co2 and methods of making and using same

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Polyether esteramide containing additives and methods of making and using same

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Corynebacterium glutamicum variant with improved l-lysine production ability, and method for producing l-lysine using same

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Corynebacterium glutamicum variant having improved l-lysine production ability, and method for producing l-lysine using same

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Filamentous organism-derived carbon-based materials, and methods of making and using same

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<sup2/>? <sub2/>?2?porous polymeric carbon sorbents for cocapture and methods of making and using same

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Duplex label with displaceable liner and methods of making and using same

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Corynebacterium glutamicum variant having enhanced l-citrulline production capacity, and method for producing l-citrulline using same

Номер патента: US20230332192A1. Автор: Moon Jeong Kim,Dong Seok Lee,Jae Chun Han,Seok Hyun Park,Min Jin Choi. Владелец: Daesang Corp. Дата публикации: 2023-10-19.

Preceramic polymer grafted nanoparticles and methods of making and using same

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Porous polymeric carbon sorbents for co2 capture and methods of making and using same

Номер патента: US20240100502A1. Автор: James M. Tour,Wilbur Carter Kittrell,Wala ALGOZEEB,Paul E. Savas, Jr.. Владелец: William Marsh Rice University. Дата публикации: 2024-03-28.

Preceramic Polymer Grafted Nanoparticles and Methods of Making and Using Same

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Preceramic Polymer Grafted Nanoparticles and Methods of Making and Using Same

Номер патента: US20210230072A1. Автор: Matthew B. Dickerson,Kara L. Martin. Владелец: US Air Force. Дата публикации: 2021-07-29.

Corynebacterium glutamicum variant having improved l-lysine production ability, and method for producing l-lysine using same

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Gelation Inhibiting Retarders for Highly Reactive Calcium Silicate Based Binder Compositions and Methods of Making and Using Same

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Assay modules having assay reagents and methods of making and using same

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Wellbore servicing fluids and methods of making and using same

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Microbiological culture bottle, and method of making and using same

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Cutting elements including binder materials having modulated morphologies, earth-boring tools including such cutting elements, and related methods of making and using same

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Cutting elements including binder materials having modulated morphologies, earth-boring tools including such cutting elements, and related methods of making and using same

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Electrodes, lithium-ion batteries, and methods of making and using same

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Electrodes, lithium-ion batteries, and methods of making and using same

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Electrodes, lithium-ion batteries, and methods of making and using same

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Electrodes, lithium-ion batteries, and methods of making and using same

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Monolithic and fractal carbon foams and methods of preparing and using same

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