Artificial antigen-specific immunoregulatory t (airt) cells

Реферат: Some embodiments of the methods and compositions provided herein relate to efficient editing of more than one genetic locus in a cell using a chemical-inducible signaling complex (CISC) system. Some embodiments include use of such systems to edit a FOXP3 locus gene and TRAC locus in a Treg cell. More embodiments herein relate to use of gene-edited Treg cells to suppress activation and/or proliferation of certain populations of cells.