New peptide compounds derived from boronic acid, process for preparing them and pharmaceutical compositions containing them
Номер патента: AU5630294A
Опубликовано: 01-09-1994
Автор(ы): Alain Rupin, Bernard Portevin, Christine Lila, Guillaume De Nanteuil, Michel Laubie, Serge Simonet, Tony Verbeuren
Принадлежит: Laboratoires Servier SAS
Опубликовано: 01-09-1994
Автор(ы): Alain Rupin, Bernard Portevin, Christine Lila, Guillaume De Nanteuil, Michel Laubie, Serge Simonet, Tony Verbeuren
Принадлежит: Laboratoires Servier SAS
Реферат: The invention relates to the compounds of formula (I): <IMAGE> in which: R1 represents a hydrogen atom or an acyl, alkyl, benzyl, alkoxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl, 5-[(dimethyl)amino]naphthylsulphonyl, alkoxycarbonylmethyl or carboxymethyl group, R2 represents a hydrogen atom or a phenyl, substituted or unsubstituted benzyl, thienyl-3-methyl, (pyrid-2-yl)methyl, diphenylmethyl, fluorenyl, naphthylmethyl, benzocyclobutyl, (dicyclopropylmethyl)methyl, indanyl or cyclo(C3-C7)alkylmethyl group, R'2 represents a hydrogen atom or a benzyl group or else R2 and R'2 together represent C6H5-CH=, R3 represents a cycloalkyl, aminobenzyl, amidinobenzyl, guanidinobenzyl, aminophenyl, amidinophenyl, guanidinophenyl or substituted alkyl group, R4 and R5 each represent a hydrogen atom or an alkyl group, or <IMAGE> forms a boronic ester of pinanediol, A represents any one of the groups as defined in the description. These compounds are useful as inhibitors of trypsin-like serine proteases such as thrombin.
Boronic acid peptidic derivatives; process for preparing the same and pharmaceutical compositions containing them
Номер патента: CA2152205A1. Автор: Philippe Gloanec,Christine Lila,Tony Verbeuren,Alain Rupin,Serge Simonet,Michel Laubie,Guillaume De Nanteuil. Владелец: Guillaume De Nanteuil. Дата публикации: 1995-12-23.