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Cdk inhibitors and their use as pharmaceuticals

Номер патента: EP4263525A1
Опубликовано: 25-10-2023
Автор(ы): Andrew Paul Combs, Andrew W. Buesking, Katarina ROHLFING, Ryan Holmes, Sarah Pawley, Xiaowei Wu
Принадлежит: Prelude Therapeutics Inc

Реферат: The disclosure is directed to compounds of Formula (I), pharmaceutical compositions comprising compounds of Formula (I), as well as methods of their use and preparation, are also described.

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Polymeric multinary azanes, methods for their preparation and their use

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Sintered spheres, method for their production and their use

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Microbiological method of obtaining chemical elements and their isotopes, including super-heavy transuranic elements

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Aqueous dispersions of graft polymers or copolymers, a process for their production and their use as hydrophobizing and oleophobizing agents for textiles

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Energy transfer dyes comprising donor & acceptor dye moieties linked via an aryl/heteroaryl containing bridge, & their use as labels in biological systems

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Bacterial cultures of Acidithiobacillus thiooxidans and their use in the treatment of materials containing sulfur-compounds

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Olefin- and alkenylalkylate-base polymers and their using as multifunctional additives to fuel

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Fluorogenic pH-Sensitive Compounds and Their Methods of Use

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Polythioether prepolymers and their use in curable compositions in particular in mastics

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Certain dialkyl amino ethyl amides, their salts and their use as anti-ripening agents

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Method of controlling parasitic weeds with mixtures comprising herbicidal acetolactate synthase inhibitors and plant growth regulators

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Method of controlling parasitic weeds with mixtures comprising herbicidal acetolactate synthase inhibitors and plant growth regulators

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Material comprising ultrafine metals and metal oxide particles and their preparation for use as catalysts in the hydrogenation of olefins or in coupling reactions

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DIQUATERAL AMMONIUM SALTS AND THEIR PRODUCTION AND USE AS A TEXTILE FINISHING AGENT.

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Optical devices, and their use for security and authentication

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A method of manufacturing resinous papers, resinous papers, and their use as resinous preform blanks

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A method of manufacturing resinous papers, resinous papers, and their use as resinous preform blanks

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Flue gas sorbents, methods for their manufacture, and their use in removal of mercury from gaseous streams

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1-(2-(2-Quinolylethyl))-4-substd piperazines - and their tetrahydro derivs useful as hypotensives

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Small Molecule Inhibitors of PFKFB3 and Glycolytic Flux and Their Methods of Use as Anti-Cancer Therapeutics

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Mixed butyric-formic esters of acid polysaccharides, and their preparation and use as skin cosmetics

Номер патента: AU2008329154B2. Автор: Marco Bosco,Luca Stucchi,Rita Gianni,Antonia Trevisan. Владелец: Sigea SRL. Дата публикации: 2013-08-08.

Phenylurea derivatives and their preparation and use as herbicides

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Phosphatidylinositol 3-kinase inhibitors and methods of their use

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KINASE INHIBITORS AND METHODS OF THEIR USE

Номер патента: US20120134987A1. Автор: LAN Jiong,Han Wooseok,Burger Matthew T.,Nishiguchi Gisele. Владелец: . Дата публикации: 2012-05-31.

PIM KINASE INHIBITORS AND METHODS OF THEIR USE

Номер патента: US20120202851A1. Автор: . Владелец: . Дата публикации: 2012-08-09.

PIM KINASE INHIBITORS AND METHODS OF THEIR USE

Номер патента: US20120208815A1. Автор: JR. William,Garcia Pablo,LAN Jiong,Shafer Cynthia,Han Wooseok,LINDVALL Mika,McBride Christopher,BURGER Matthew,ATALLAH Gordana,Walter Annette,Huh Kay,Zavorotinskaya Tatiana,Nishiguchi Gisele,Antonios-McCrea,Bellamacina Comelia. Владелец: . Дата публикации: 2012-08-16.

Pi-3 kinase inhibitors and methods of their use

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PHENYLALANINE DERIVATIVES AND THEIR USE AS NON-PEPTIDE GLP-1 RECEPTOR MODULATORS

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NOVEL INDOLYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL AND DIAGNOSTICAL USE

Номер патента: US20120003153A1. Автор: Peters Dan,Timmermann Daniel B.,Nielsen Elsebet Østergaard,Dyhring Tino,Christensen Jeppe Kejser. Владелец: NEUROSEARCH A/S. Дата публикации: 2012-01-05.

N-OXIDES OF DIAZABICYCLONONYL PYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE

Номер патента: US20120004215A1. Автор: . Владелец: NEUROSEARCH A/S. Дата публикации: 2012-01-05.

PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS

Номер патента: US20120004246A1. Автор: Peters Dan,Eriksen Birgitte L.,Sorensen Ulrik Svane,Hougaard Charlotte,Christophersen Palle. Владелец: NEUROSEARCH A/S. Дата публикации: 2012-01-05.

PHENYLCYCLOPROPYLAMINE DERIVATIVES AND THEIR MEDICAL USE

Номер патента: US20120004262A1. Автор: Guibourt Nathalie,ORTEGA MUÑOZ Alberto,CASTRO-PALOMINO LARIA Julio. Владелец: . Дата публикации: 2012-01-05.

GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

Номер патента: US20120004273A1. Автор: Ahmad Nadia Mamoona,Branch Clive Leslie,Jaxa-Chamiec Albert Andrzej,Quai Lai Justine Yeun,Nash David John. Владелец: . Дата публикации: 2012-01-05.

Derivatives of pyridazinone and triazinone and their using as pharmaceutical preparations

Номер патента: RU2279428C2. Автор: Синдзи Хатакеяма,Йосихико НОРИМИНЕ,Коки КАВАНО,Коити ИТО,Сатоси НАГАТО,Кохси УЕНО,Такахиса ХАНАДА,Хироюки АМИНО,Макото ОГО,Масатака УЕНО,Энтони Джон ГРУМ,Лианн РИВЕРЗ,Теренс СМИТ,Йосихико НОРИМИНЕ (JP),Сатоси НАГАТО (JP),Коки КАВАНО (JP),Коити ИТО (JP),Кохси УЕНО (JP),Такахиса ХАНАДА (JP),Хироюки АМИНО (JP),Макото ОГО (JP),Синдзи ХАТАКЕЯМА (JP),Масатака УЕНО (JP),Энтони Джон ГРУМ (GB),Лианн РИВЕРЗ (GB),Теренс СМИТ (GB). Владелец: Эйсай Ко., Лтд.. Дата публикации: 2006-07-10.

AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS

Номер патента: US20120004243A1. Автор: . Владелец: AstraZeneca AB. Дата публикации: 2012-01-05.

TAGGED OLIGONUCLEOTIDES AND THEIR USE IN NUCLEIC ACID AMPLIFICATION METHODS

Номер патента: US20120003651A1. Автор: BECKER Michael M.,LIVEZEY Kristin W.,LAM Wai-Chung. Владелец: GEN-PROBE INCORPORATED. Дата публикации: 2012-01-05.

BACILLUS ISOLATES AND METHODS OF THEIR USE TO PROTECT AGAINST PLANT PATHOGENS AND VIRUS TRANSMISSION

Номер патента: US20120003197A1. Автор: JACOBSEN Barry J.,Bradley Clifford,Zidack Nina K.,Larson Rebecca. Владелец: MONTANA STATE UNIVERSITY. Дата публикации: 2012-01-05.

Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors

Номер патента: US20120004244A1. Автор: NILSSON Peter,Pelcman Benjamin,Katkevics Martins. Владелец: BIOLIPOX AB. Дата публикации: 2012-01-05.

VIOLET LASER EXCITABLE DYES AND THEIR METHOD OF USE

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กระบวนการสำหรับการจัดเตรียมสารยับยั้ง pan-CDK (pan-CDK inhibitors) ตามสูตร (I), และอินเทอร์มิเดียทของการจัดเตรียม

Номер патента: TH129240A. Автор: โลวิส ดร.ไค,ครูเกอร์ ดร.โจอาคิม,กรีส ดร.ยอร์ค,ฮาสเฟลด์ ดร.จอร์มา. Владелец: นายณัฐพล อร่ามเมือง. Дата публикации: 2013-11-14.

Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors

Номер патента: US20120004228A1. Автор: . Владелец: BIOLIPOX AB. Дата публикации: 2012-01-05.

METHOD FOR PRODUCING LIPASE, TRANSFORMED YARROWIA LIPOLYTICA CELL CAPABLE OF PRODUCING SAID LIPASE AND THEIR USES

Номер патента: US20120003716A1. Автор: Leblond Yves,Mouz Nicolas,Marty Alain,Uribelarrea Jean-Louis. Владелец: LABORATOIRES MAYOLY SPINDLER. Дата публикации: 2012-01-05.

กระบวนการสำหรับการจัดเตรียมสารยับยั้ง pan-CDK (pan-CDK inhibitors) ตามสูตร (I), และอินเทอร์มิเดียทของการจัดเตรียม

Номер патента: TH129240B. Автор: ดร.ยอร์ค กรีส ดร.ไค โลวิส ดร.จอร์มา ฮาสเฟลด์ ดร.โจอาคิม ครูเกอร์. Владелец: เบเยอร์ อินเทลเล็คชวล พร็อพเพอตี้ จีเอ็มบีเอช. Дата публикации: 2013-11-14.

SUBSTITUTED DIKETOPIPERAZINES AND THEIR USE AS OXYTOCIN ANTAGONISTS

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INTERMEDIATE COMPOUNDS AND THEIR USE IN PREPARATION OF LACOSAMIDE

Номер патента: US20120004452A1. Автор: MADHRA Mukesh Kumar,Singh Pankaj Kumar,Khanduri Chandra Has. Владелец: . Дата публикации: 2012-01-05.

INTERMEDIATE COMPOUNDS AND THEIR USE IN PREPARATION OF LACOSAMIDE

Номер патента: US20120004462A1. Автор: MADHRA Mukesh Kumar,Singh Pankaj Kumar,Khanduri Chandra Has. Владелец: RANBAXY LABORATORIES LIMITED. Дата публикации: 2012-01-05.

Farnesyl dibenzodiazepinones, processes for their production and their use as pharmaceuticals

Номер патента: CA2497031A1. Автор: James B. McAlpine. Владелец: Ecopia Biosciences Inc. Дата публикации: 2006-05-08.

Isoxazoline compositions and their use as antiparasitics

Номер патента: AU2020230282A1. Автор: Takeshi Mita,Jürgen Lutz,Anja Regina Heckeroth,Christina Mertens,Heike Williams,Hartmut Zoller. Владелец: Intervet International BV. Дата публикации: 2020-10-01.

Composite materials suitable for direct decoration and method of their manufacture and their use

Номер патента: RU2464176C2. Автор: Клаус Фридрих ГЛЯЙХ,Михель КЕТЦЕР,Бернд КРИСТЕНСЕН,Алан ДЖЭФФИ,Фил МАЙЕЛ,Гленда БЕННЕТТ,Бернхард ЭККЕРТ,Аннетт АЛЬБРЕХТ. Владелец: Джонс Мэнвилл Юроп Гмбх. Дата публикации: 2012-10-20.

Aspartyl derivatives of histamine, method for their preparing, pharmaceutical composition and their using as modulators of enzyme activity of antioxidant protection

Номер патента: RU2287524C1. Автор: Владимир Евгеньевич Небольсин,Галина Александровна Желтухина,Татьяна Александровна Кромова,Тать на Александровна Кромова. Владелец: ООО "Фарминтерпрайсез". Дата публикации: 2006-11-20.

Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals.

Номер патента: OA17884A. Автор: Heinz-Werner Kleemann,Matthias Schaefer,Marcel Patek,Josef Pernerstorfer,Alena Safarova. Владелец: SANOFI. Дата публикации: 2018-02-27.

Derivatives of aminoquinoline and their using as adenosine a3 ligands

Номер патента: RU2317290C2. Автор: Зольтан Капуи,Геза Тимари,Шандор Батори,Эндре Микуш,Середи Юдит Варгане,Кинга БОЭР,Каталин УРБАН-САБО,Петер Арани,Каталин Гербер,Мишель ФИНЕТ. Владелец: Санофи-Авентис. Дата публикации: 2008-02-20.

Aminothiolester compound or derivative thereof for use as an immunomodulatory agent

Номер патента: OA21453A. Автор: GUILLAUME MARTIN,Mileidys PEREZ. Владелец: ADVANCED BIODESIGN. Дата публикации: 2024-06-20.

RECOMBINANT PLASMID DNA pcL37 ENCODING POLYPEPTIDE WITH PROPERTIES OF HUMAN LIGHT CHAIN OF ANTIBODY AGAINST SMALLPOX VIRUS VACCINE, RECOMBINANT PLASMID DNA pcH37 ENCODING POLYPEPTIDE WITH PROPERTIES OF HEAVY CHAIN OF INDICATED ANTIBODY AND THEIR USING

Номер патента: RU2317330C2. Автор: Нина Викторовна Тикунова,Вера Витальевна Морозова,Александр Алексеевич Ильичев,Теймур Кантамирович Алиев,Михаил Петрович Кирпичников,Анна Алексеевна Панина,Людмила Николаевна Шингарова,Елена Филипповна Болдырева,Оксана Васильевна Некрасова,Лев Степанович Сандахчиев,Татьяна Эверестовна Юн,Илона Владимировна Полыхалова. Владелец: Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова Российской академии наук (ИБХ РАН). Дата публикации: 2008-02-20.

Pyridazine derivatives and their use as therapeutic agents

Номер патента: SG145720A1. Автор: . Владелец: Zhang Zaihui Agent S Ella Cheo. Дата публикации: 2008-09-29.

Substituted phthalazines and their use as therapeutic agents

Номер патента: JO971B1. Автор: ويليام بريستو نورمان,ادوارد ماسي بيتر,جون نيكول كينيث,فريمان سيم مالكولم. Владелец: ذي بوتس كومباني ليمتد. Дата публикации: 1979-12-01.

Novel n-(substituted phenyl) n-benzoyl - ureas and their use as insecticides

Номер патента: JO863B1. Автор: سيرنبرج ولهلم,كلاوكي اريخ,هامان انجيورج,ستندال ولهلم. Владелец: باير اكتنجسلشافت. Дата публикации: 1978-09-30.

Recombinant vesiculoviruses and their uses

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Benzodiazepine compounds and their use as pharmaceuticals

Номер патента: CA1164457A. Автор: Terrence M. Hotten,Jiban K. Chakrabarti. Владелец: Lilly Industries Ltd. Дата публикации: 1984-03-27.

1-(pyridinyl-2)-2-azolyl-1-(fluorophenyl)ethanols and their using as fungicides

Номер патента: RU2267483C2. Автор: Сергей Владимирович Попков,Александр Владимирович Кузенков,Владимир Владимирович Захарычев. Владелец: Российский химико-технологический университет им. Д.И. Менделеева (РХТУ им. Д.И. Менделеева). Дата публикации: 2006-01-10.

Isoxazoline compositions and their use as antiparasitics

Номер патента: AU2022203370B2. Автор: Takeshi Mita,Jürgen Lutz,Anja Regina Heckeroth,Christina Mertens,Heike Williams,Hartmut Zoller. Владелец: Intervet International BV. Дата публикации: 2024-06-20.

Improved parasiticidal compositions and their manufacture

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Substituted 1-piperidin-3-yl-4-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists

Номер патента: EP1578425A1. Автор: Joseph Elisabeth Leenaerts,Frans Eduard Janssens,Francois Maria Sommen,Benoit Christian Albert Ghislain De Boeck. Владелец: Janssen Pharmaceutica NV. Дата публикации: 2005-09-28.

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