Blockade of sars-cov-2 infection using hydrocarbon stapled peptides
Номер патента: EP4267166A1
Опубликовано: 01-11-2023
Автор(ы): James L. Labelle, Jeffrey A. Hubbell, Matthew A. TIRRELL, Sicheng JIANG, Yu Tian
Принадлежит: University of Chicago
Опубликовано: 01-11-2023
Автор(ы): James L. Labelle, Jeffrey A. Hubbell, Matthew A. TIRRELL, Sicheng JIANG, Yu Tian
Принадлежит: University of Chicago
Реферат: The disclosure is directed to methods of inhibiting coronavirus infection using a hydrocarbon stapled peptide which is a peptidomimetic of the human angiotensin-converting enzyme 2 (hACE2). The hydrocarbon stapled peptide binds to the receptor binding domain (RBD) of a coronavirus spike protein (S) and inhibits binding of the coronavirus to hACE2 expressed on the surface of host cells.
Blockade of sars-cov-2 infection using hydrocarbon stapled peptides
Номер патента: US20240052330A1. Автор: Yu Tian,Jeffrey A. Hubbell,James L. Labelle,Sicheng JIANG,Matthew A. TIRRELL. Владелец: University of Chicago. Дата публикации: 2024-02-15.