Peptide agonists and antagonists of tlr4 activation
Номер патента: EP3416667A1
Опубликовано: 26-12-2018
Автор(ы): Amit MICHAELI, Anke Burger-Kentischer, Immanuel LERNER, Steffen Rupp
Принадлежит: Pepticom Ltd
Опубликовано: 26-12-2018
Автор(ы): Amit MICHAELI, Anke Burger-Kentischer, Immanuel LERNER, Steffen Rupp
Принадлежит: Pepticom Ltd
Реферат: A group of peptides is provided which activate or inhibit toll-like receptor 4 (TLR4) and may be used to modulate inflammatory signaling and host defense pathways. The peptides were derived in silico and tested in vitro in cell cultures. These peptides may be used in the preparation of immunomodulatory compositions such as vaccine adjuvants and in pharmaceutical compositions for immunomodulation of the innate immune system such as vaccine adjuvants. The peptides may also be used in the preparation of TLR4 activators, TLR4 inhibitors and MD2 labels, e.g., for research purposes.
Peptide agonists and antagonists of tlr4 activation
Номер патента: US20200247849A1. Автор: Steffen Rupp,Anke Burger-Kentischer,Immanuel LERNER,Amit MICHAELI. Владелец: Pepticom Ltd. Дата публикации: 2020-08-06.