Compositions and methods for thymic regeneration and t-cell reconstitution
Номер патента: EP3976065A1
Опубликовано: 06-04-2022
Автор(ы): Daniel Joseph NOLAN, Karolina KUCHAROVA, Kenneth N. Wills, Michael Daniel GINSBERG, Paul William FINNEGAN
Принадлежит: Angiocrine Bioscience Inc
Опубликовано: 06-04-2022
Автор(ы): Daniel Joseph NOLAN, Karolina KUCHAROVA, Kenneth N. Wills, Michael Daniel GINSBERG, Paul William FINNEGAN
Принадлежит: Angiocrine Bioscience Inc
Реферат: The present invention provides non-thymic endothelial cells (ntECs) engineered to express adenovirus E4ORF1 and/or BMP4, and compositions comprising such engineered ntECs. The present invention also provides methods of using such ntECs in therapy, for example to enhance thymic regeneration (including T cell reconstitution) in subjects in need thereof. Such subjects include those that have a damaged thymus, defective thymic function, insufficient T-cell output, and/or that are immunocompromised - for example as a result of ageing, infection (e.g. with HIV), treatment with radiation therapy, treatment with chemotherapy, or myeloablative conditioning in preparation for an organ/tissue transplant.
Compositions and methods for thymic regeneration and t-cell reconstitution
Номер патента: WO2020243310A1. Автор: Paul William FINNEGAN,Michael Daniel GINSBERG,Daniel Joseph NOLAN,Kenneth N. Wills,Karolina KUCHAROVA. Владелец: Angiocrine Bioscience, Inc.. Дата публикации: 2020-12-03.