Broadly neutralizing antibodies against hiv
Номер патента: EP3641806A1
Опубликовано: 29-04-2020
Автор(ы): Anthony Devico, Dongkyoon KIM, George K. Lewis, Guy Cavet, Mohammad SAJADI
Принадлежит: University of Maryland at Baltimore, US Department of Veterans Affairs VA
Опубликовано: 29-04-2020
Автор(ы): Anthony Devico, Dongkyoon KIM, George K. Lewis, Guy Cavet, Mohammad SAJADI
Принадлежит: University of Maryland at Baltimore, US Department of Veterans Affairs VA
Реферат: The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof. Specifically, the invention provides isolated anti-HIV antibodies that are capable of neutralizing at least 95% of the HIV pseudoviruses listed in Table 1 and neutralizing 100% of the HIV clade B, G and D viruses listed in Table 1 with an IC50 value of less than 50 ug/mL. Further provides are the sequences especially complementarity-determining region (CDR) sequences of antibodies disclosed.
Broadly neutralizing antibodies against hiv
Номер патента: WO2018237357A1. Автор: George K. Lewis,Guy Cavet,Anthony Devico,Mohammad SAJADI,Dongkyoon KIM,Amir Dashti,Marzena E. Pazgier,William David Tolbert. Владелец: The United States Government as represented by the Department of Veterans Affairs. Дата публикации: 2018-12-27.