Compositions and methods for promoting bone regeneration
Номер патента: EP3826693A1
Опубликовано: 02-06-2021
Автор(ы): Chuying Ma, Jian Yang
Принадлежит: PENN STATE RESEARCH FOUNDATION
Опубликовано: 02-06-2021
Автор(ы): Chuying Ma, Jian Yang
Принадлежит: PENN STATE RESEARCH FOUNDATION
Реферат: This invention relates to compositions and methods for promoting and/or accelerating bone regeneration, repair, and/or healing and, in particular, to compositions and methods of promoting bone regeneration, growth, repair, and/or healing using graft or scaffold materials. In exemplary embodiments, the disclosed compositions may be used to promote and/or accelerate bone regeneration by delivering a composition to a bone site, the composition comprising (a) a citrate component, (b) a phosphate component, and, optionally, (c) a particulate inorganic material. The citrate component and/or phosphate component is advantageously released from the composition at the bone site. The released citrate component may function to increase alkaline phosphatase activity and/or expression at the bone site, and the increased alkaline phosphatase activity and/or expression may release the phosphate component. The composition may be delivered in various forms, e.g., as a biodegradable scaffold.
Compositions and methods for promoting bone regeneration
Номер патента: US11738042B2. Автор: Jian Yang,Chuying Ma. Владелец: PENN STATE RESEARCH FOUNDATION. Дата публикации: 2023-08-29.