Polyisoprenyl benzophenones as inhibitors of histone acetyl transferases and uses thereof
Номер патента: EP1694622A2
Опубликовано: 30-08-2006
Автор(ы): A Varier 12/32.-A Karthika Nivas RADHIKA, Altaf Mohammad, Karanam 145 Padmalaya BALASUBRAMANYAM, Kempegowda MAKANAHALLI MANTELINGU, Kundu JJ-D1 type quarters TAPAS KUMAR, Venkatesh Swaminathan
Принадлежит: Jawaharial Nehru Centre for Advanced Scientific Research
Опубликовано: 30-08-2006
Автор(ы): A Varier 12/32.-A Karthika Nivas RADHIKA, Altaf Mohammad, Karanam 145 Padmalaya BALASUBRAMANYAM, Kempegowda MAKANAHALLI MANTELINGU, Kundu JJ-D1 type quarters TAPAS KUMAR, Venkatesh Swaminathan
Принадлежит: Jawaharial Nehru Centre for Advanced Scientific Research
Реферат: In this patent we describe the purification of prenylated benzophenones from the fruit rinds of Garcinia species and its evaluation as an inhibitor for Histone acetyltransferases p300 and PCAF. We have found that prenylated benzophenones are potent HAT inhibitors of p300 (IC<SUB>50</SUB>-1 muM) and pCAF (IC<SUB>50</SUB>-15 muM). The inhibitors significantly repress the p300 HAT dependent transcriptional activation from in vitro assembled chromatin template but had no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs. Thus these compounds should be useful as biological switching molecule for evaluating the role of p300 and PCAF in cellular functions and may be useful as new chemical entities for the development of anticancer drugs.
Polyisoprenyl benzophenones as inhibitors of histone acetyl transferases and uses thereof
Номер патента: WO2005047457B1. Автор: Altaf Mohammad,Karanam Balasubramanyam,Kempegowda Mantelingu,Venkatesh Swaminathan,A Varier Radhika,Kumar Kundu Tapas. Владелец: Kumar Kundu Tapas. Дата публикации: 2005-12-01.