Recombinant t-cell receptors that bind the ny-eso-1 and/or lage-1a cancer antigens
Номер патента: EP4237433A1
Опубликовано: 06-09-2023
Автор(ы): Erika VON EUW, Gang Zeng, Maize Wang, Nicholas S. DAVIS, Ying Q. LIN
Принадлежит: T Cure Biosciences Inc
Опубликовано: 06-09-2023
Автор(ы): Erika VON EUW, Gang Zeng, Maize Wang, Nicholas S. DAVIS, Ying Q. LIN
Принадлежит: T Cure Biosciences Inc
Реферат: The present invention relates to recombinant T-cell receptors that bind specifically, in a MHC restricted manner, to a particular epitope present in the shared cancer-testis antigen known as NY-ESO-1 and/or a particular epitope present in the closely related antigen LAGE-1. The invention provides T-cell receptor related polypeptides, fragments, and functional variants thereof, as well as nucleic acids encoding the T-cell receptor polypeptides of the invention, recombinant expression vectors, and genetically modified cells (for example, T-cells) expressing the T-cell receptors, and their use in methods for diagnosing, treating or preventing cancer in a subject.
Recombinant t-cell receptors that bind the ny-eso-1 and/or lage-1a cancer antigens
Номер патента: AU2021370288A9. Автор: Gang Zeng,Erika VON EUW,Maize Wang,Ying Q. LIN,Nicholas S. DAVIS. Владелец: T Cure Bioscience Inc. Дата публикации: 2024-10-24.