Pyridine derivates useful as hcn2 modulators
Номер патента: EP4301743A1
Опубликовано: 10-01-2024
Автор(ы): Alan Naylor, Karen Williams, Peter A. MCNAUGHTON, Sue Cramp
Принадлежит: KINGS COLLEGE LONDON
Опубликовано: 10-01-2024
Автор(ы): Alan Naylor, Karen Williams, Peter A. MCNAUGHTON, Sue Cramp
Принадлежит: KINGS COLLEGE LONDON
Реферат: Compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein the substituents are defined in the specification. The compounds are hyperpolarisation activated cyclic-nucleotide modulated ion channel 2 (HCN2) inhibitors. Also disclosed are pharmaceutical compositions comprising the compounds, and the use of the compounds for the treatment or prevention of medical conditions mediated by HCN2, including neuropathic pain.
Pyridine derivatives and their use as sodium channel activators
Номер патента: EP4405347A1. Автор: Wei Zhang,Shawn Johnstone,Shaoyi Sun,Paul Charifson,Jung Yun Kim,Kristen Burford,Juliette SABBATANI,Verner Lofstrand,Helen Clement,Jan Felix Scholtes. Владелец: Xenon Pharmaceuticals Inc. Дата публикации: 2024-07-31.