Halogenated triptolide derivatives as immunomodulators and anticancer agents
Номер патента: EP1603555A4
Опубликовано: 02-11-2006
Автор(ы): Dongcheng Dai, John H Musser
Принадлежит: Pharmagenesis Inc
Опубликовано: 02-11-2006
Автор(ы): Dongcheng Dai, John H Musser
Принадлежит: Pharmagenesis Inc
Реферат: Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR<SUP>1</SUP>R<SUP>2 </SUP>is selected from CHOH, C-O, CHF, CF<SUB>2 </SUB>and C(CF<SUB>3</SUB>)OH; CR<SUP>6 </SUP>and CR<SUP>13 </SUP>are selected from CH, COH and CF; CR<SUP>7</SUP>R<SUP>8</SUP>, CR<SUP>9</SUP>R<SUP>10 </SUP>and CR<SUP>11</SUP>R<SUP>12 </SUP>are selected from CH<SUB>2</SUB>, CHOH, C-O, CHF and CF<SUB>2</SUB>; and CR<SUP>3</SUP>R<SUP>4</SUP>R<SUP>5 </SUP>is selected from CH<SUB>3</SUB>, CH<SUB>2</SUB>OH, C-O, COOH, CH<SUB>2</SUB>F, CHF<SUB>2 </SUB>and CF<SUB>3</SUB>; such that: at least one of R<SUP>1</SUP>-R<SUP>13 </SUP>comprises fluorine; no more than two of CR<SUP>3</SUP>R<SUP>4</SUP>R<SUP>5</SUP>, CR<SUP>6</SUP>, CR<SUP>7</SUP>R<SUP>8</SUP>, CR<SUP>9</SUP>R<SUP>10</SUP>, CR<SUP>11</SUP>R<SUP>12</SUP>, and CR<SUP>13 </SUP>comprises fluorine or oxygen; and, when CR<SUP>1</SUP>R<SUP>2 </SUP>is CHOH, CR<SUP>3</SUP>R<SUP>4</SUP>R<SUP>5 </SUP>is not CH<SUB>2</SUB>F.
Halogenated triptolide derivatives as immunomodulators and anticancer agents
Номер патента: EP1603555A2. Автор: John H. Musser,Dongcheng Dai. Владелец: Pharmagenesis Inc. Дата публикации: 2005-12-14.