Chimeric papillomavirus l1 protein
Номер патента: MY197457A
Опубликовано: 19-06-2023
Автор(ы): Chunxia Luo, Liangzhi Xie, LIN Pang, Ping Hu, Wei Zhang, Xiaoyan Suo
Принадлежит: Sinocelltech Ltd
Опубликовано: 19-06-2023
Автор(ы): Chunxia Luo, Liangzhi Xie, LIN Pang, Ping Hu, Wei Zhang, Xiaoyan Suo
Принадлежит: Sinocelltech Ltd
Реферат: The present invention relates to chimeric papilloma virus L1 proteins and polynucleotides encoding thereof, and also to HPV virus-like particles and the preparation methods thereof. Said chimeric papilloma virus L1 protein comprises an N-terminal fragment derived from L1 protein of the first papilloma virus type , said N-terminal fragment maintains the immunogenicity of the L1 protein of the corresponding type of HPV; and a C-terminal fragment derived from L1 protein of the second papilloma virus type , said L1 protein of the second papilloma virus type has a better expression level and a better solubility compared to the L1 proteins of other HPV types; wherein said chimeric papilloma virus L1 proteins have the immunogenicity of the L1 proteins of the corresponding HPV types. Said chimeric papilloma virus L proteins have better expression amount and solubility for mass production of vaccines.
Chimeric papillomavirus L1 protein
Номер патента: AU2020318114B2. Автор: Wei Zhang,LIN Pang,Ping Hu,Liangzhi Xie,Chunxia Luo,Xiaoyan Suo. Владелец: Sinocelltech Ltd. Дата публикации: 2024-07-11.