Antibody variants
Номер патента: GB9603507D0
Опубликовано: 17-04-1996
Автор(ы):
Принадлежит: Oxford University Innovation Ltd
Опубликовано: 17-04-1996
Автор(ы):
Принадлежит: Oxford University Innovation Ltd
Реферат: This invention relates to an antibody which is modified version of a therapeutic antibody with affinity for a cell-surface antigen, the antibody having reduced affinity for the antigen compared with the therapeutic antibody as a result of a modification or modifications to the antibody molecule, wherein the antibody is capable of inducing immunological tolerance to the therapeutic antibody. The invention further relates to a method of inducing immunological tolerance to a therapeutic antibody, comprising administering to a patient an antibody which is a modified version of the therapeutic antibody and which has reduced affinity for the antigen as compared with the therapeutic antibody.
Antibody variants
Номер патента: CA2246715A1. Автор: Herman Waldmann,Masahide Tone,Lisa Kim Gilliland,Mark Raymond Frewin,Louise Walsh. Владелец: Louise Walsh. Дата публикации: 1997-08-28.