Indazoles as glucocorticoid receptor ligands
Номер патента: EP1869003A1
Опубликовано: 26-12-2007
Автор(ы): Colin David GlaxoSmithKline ELDRED, David GlaxoSmithKline HOUSE, Graham George Adam GlaxoSmithKline INGLIS, Philip Alan GlaxoSmithKline SKONE, Simon John Fawcett GlaxoSmithKline MACDONALD
Принадлежит: Glaxo Group Ltd
Опубликовано: 26-12-2007
Автор(ы): Colin David GlaxoSmithKline ELDRED, David GlaxoSmithKline HOUSE, Graham George Adam GlaxoSmithKline INGLIS, Philip Alan GlaxoSmithKline SKONE, Simon John Fawcett GlaxoSmithKline MACDONALD
Принадлежит: Glaxo Group Ltd
Реферат: The present invention is directed to compounds of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents -C(R3)- or nitrogen; when X represents -C(R3)-, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents -C(R3)- and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents -C(R3)- and R2 represents hydroxy, methoxy, -CO2CH3 or -CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; and physiologically functional derivatives thereof, pharmaceutical compositions and formulations comprising the compounds, the use of the compounds for the manufacture of medicaments particularly for the treatment of inflammatory and/or allergic conditions and/or skin diseases, processes for the preparation of the compounds, and chemical intermediates in the processes for the manufacture of the compounds.
Indazoles as glucocorticoid receptor ligands
Номер патента: US20090074675A1. Автор: Colin David Eldred,David House,Simon John Fawcett Macdonald,Graham George Adam Inglis,Philip Alan Skone. Владелец: Glaxo Group Ltd. Дата публикации: 2009-03-19.