Heterogeneous synthesis of azepinones from esters
Номер патента: AU6138290A
Опубликовано: 07-03-1991
Автор(ы): Daniel E. Martin
Принадлежит: Marion Merrell Dow Inc
Опубликовано: 07-03-1991
Автор(ы): Daniel E. Martin
Принадлежит: Marion Merrell Dow Inc
Реферат: An amino-acid ester compound can be cyclized into a cyclic amido-carbonyl compound by contacting the amino-acid ester compound in a liquid medium with a heterogeneous acidic ion-exchange substance. For example, 2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)propionic acid, methyl ester, threo form, can be cyclized in an aqueous mixture into cis-2-(4-methoxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H) -one by employing a sulfonated polystyrene-divinylbenzene ion-exchange resin in its acid form, e.g., Dowex 50X4-400, at yields exceeding 85 percent of theory, and the product can be used to make diltiazem hydrochloride.
Method of synthesis of 3-hydroxy-5-[2-(dimethylamino)-ethyl]- -2,3-dihydro-4-(methoxyphenyl)-1,5-benzothiazepine-4-(5h)-on'e method of synthesis of benzothiazepine derivatives, method of synthesis of cis-(+)-3-acetoxy-5-[2-(dimethylamino)-ethyl]- -2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepine-4-(5h)-on'e
Номер патента: RU2141957C1. Автор: Хютенен Мартти. Владелец: Орион Корпорейшн Фермион. Дата публикации: 1999-11-27.