Specific conjugation for an antibody-drug conjugate
Номер патента: EP4426729A1
Опубликовано: 11-09-2024
Автор(ы): Hangbo YE, Huihui GUO, Juan Wang, Junxiang JIA, Lingli Zhang, Linyao ZHAO, LU Bai, Qingliang YANG, Robert Zhao, Wenjun Li, Xiaolei Liu, Yuanyuan Huang, Zhicang YE
Принадлежит: Hangzhou Dac Biotech Co Ltd
Опубликовано: 11-09-2024
Автор(ы): Hangbo YE, Huihui GUO, Juan Wang, Junxiang JIA, Lingli Zhang, Linyao ZHAO, LU Bai, Qingliang YANG, Robert Zhao, Wenjun Li, Xiaolei Liu, Yuanyuan Huang, Zhicang YE
Принадлежит: Hangzhou Dac Biotech Co Ltd
Реферат: Provided herein is a process for preparing a homogeneous conjugate of an antibody or antibody-like protein via linkage of cysteine sites between heavy-light chains in the IgG antibody or antibody-like protein. Provided herein also are methods of making the conjugates in a specific manner comprising either generation of specific thiols of an antibody or antibody-like protein agent, followed by reaction with drug/linker complexes, or generation of specific thiols of an antibody or antibody-like protein agent and conjugation of a synthetic linker-drug assembly with the thiols simultaneously in one pot reaction, to provide conjugates with over 75%, in most cases more than 80%of payloads linked at the specific cysteine sites between heavy-light chains of the IgG antibody or antibody-like protein. It also relates to methods of using the homogeneous conjugate in targeted prophylaxis or treatment of cancer, infection and immunological disorders.
Bcma monoclonal antibody and the antibody-drug conjugate
Номер патента: EP4426741A1. Автор: Robert Yongxin Zhao,Qingliang YANG,Yuanyuan Huang,Hangbo YE,Huihui GUO,Junxiang JIA,Wenjun Li,Juan Wang,Zhicang YE,You Zhou,Lingli Zhang,Yunxia ZHENG. Владелец: Hangzhou Dac Biotech Co Ltd. Дата публикации: 2024-09-11.