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Substituted 3,4-dihydropyrrolo[1,2-A]pyrazines as beta-secretase (BACE) inhibitors

Номер патента: US09845326B2
Опубликовано: 19-12-2017
Автор(ы): Andrés Avelino Trabanco-Suárez, Francisca Delgado-Jiménez
Принадлежит: Janssen Pharmaceutica NV
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1,3-OXAZIN-2-AMINE COMPOUNDS FUSED WITH PERFLUORATED CYCLOPROPYL AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

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C6-azaspiro iminothiadiazine dioxides as bace inhibitors

Номер патента: EP2934149A4. Автор: Ulrich Iserloh,Andrew W Stamford,Jack D Scott,Jared N Cumming,David Earl Kaelin Jr. Владелец: Merck Sharp and Dohme LLC. Дата публикации: 2016-06-15.

Crystalline form of a BACE inhibitor, compositions, and use

Номер патента: US11306080B2. Автор: William Morris,Richard J. Varsolona,Laura M. Artino,Eric Sirota. Владелец: Merck Sharp and Dohme LLC. Дата публикации: 2022-04-19.

Hydantoins that modulate BACE-mediated APP processing

Номер патента: US09926280B2. Автор: VARGHESE John,Dale E. Bredesen. Владелец: BUCK INSTITUTE FOR RESEARCH ON AGING. Дата публикации: 2018-03-27.

Substituted piperidines as therapeutic compounds

Номер патента: WO2009121914A1. Автор: Stefan Stutz,Peter Herold,Robert Mah,Vincenzo Tschinke,Dirk Behnke,Aleksandar Stojanovic,Stjepan Jelakovic. Владелец: NOVARTIS AG. Дата публикации: 2009-10-08.

Amino-pyridines as inhibitors of .beta.-secretase

Номер патента: CA2593857A1. Автор: Albert Jean Robichaud,Frank Eldridge Lovering,Jeffrey Scott Condon,William Floyd Fobare,Michael Sotirios Malamas,William Ronald Solvibile, Jr.. Владелец: William Ronald Solvibile, Jr.. Дата публикации: 2006-08-10.

2-amino-5-piperidinylimidazolone compounds and use thereof for .beta.-secretase modulation

Номер патента: CA2634037A1. Автор: Yi Fan,Ping Zhou,Eric Steven Manas,Derek Cecil Cole,Pawel Wojciech Nowak,Yinfa Yan,Ronald Charles Bernotas,Yanfang Li. Владелец: Yanfang Li. Дата публикации: 2007-07-12.

Diaminoalcohols derivatives for the treatment of Alzheimer, malaria, HIV

Номер патента: EP1764098A1. Автор: Stefan Stutz,Peter Herold,Robert Mah,Vincenzo Tschinke,Dirk Behnke,Aleksandar Stojanovic,Christiane Marti,Christoph Schumacher,Nathalie Jotterand,Michael Quirmbach. Владелец: Speedel Experimenta AG. Дата публикации: 2007-03-21.

C6-AZASPIRO IMINOTHIADIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

Номер патента: US20160043774A1. Автор: Stamford Andrew W.,Scott Jack D.,Cumming Jared N.,Iserloh Ulrich,Kaelin,JR. David Earl. Владелец: . Дата публикации: 2016-02-11.

Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds

Номер патента: CA2900028C. Автор: Brian Thomas O'neill,Michael Aaron Brodney,Elizabeth Mary Beck,Christopher Ryan BUTLER. Владелец: PFIZER INC. Дата публикации: 2017-10-10.

Pyrrolidine derivatives useful as base inhibitors

Номер патента: US20070213331A1. Автор: Robert Dally,David Bender,Timothy Shepherd,Maria Rojo Garcia. Владелец: Eli Lilly and Co. Дата публикации: 2007-09-13.

อนุพันธ์ 5,6-ไดไฮโดร-2H-[1,4]ออกซาซิน-3-อิล-เอมีน ที่มีประโยชน์ในการเป็น สารยับยั้งของเบต้า-ซีเครเตส (BACE) (5,6-Dihydro-2H-[1,4]oxazin-3-yl-aminederivatives useful as inhibitors beta-secretase (BACE))

Номер патента: TH139645A. Автор: เจมส์,มิเชล,แจน,มาเรีย,อังเดร,จอห์น,ลุค,เฟรเดริค,แม็คโดนัลด์,แกรี่ย์,ริตา,เกรเกอร์,รอมเบาท์ส,ทราบันโก-ซัวเรซ,อะเวลีโน่,เทรซาเดิร์น,กูล แวน,ลาเมนก้า มาร์ติเนซ,แคโรไลน่า,กีจเซน,เฮนริคัส,จาโคบัส. Владелец: นางสาวเสาวลักษณ์ ล้ำเลิศ. Дата публикации: 2015-02-20.

SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS

Номер патента: US20120101093A1. Автор: Gaddam Bapu,Polisetti Dharma Rao,Rao Mohan,Mjalli Adnan M. M.,Xie Rongyuan,Gohimukkula Devi Reddy,El Abdellaoui Hassan,Andrews Robert Carl,Ren Tan,Hari Anitha. Владелец: HIGH POINT PHARMACEUTICALS, LLC. Дата публикации: 2012-04-26.

SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS

Номер патента: US20120101125A1. Автор: Gaddam Bapu,Polisetti Dharma Rao,Rao Mohan,Mjalli Adnan M. M.,Xie Rongyuan,Gohimukkula Devi Reddy,El Abdellaoui Hassan,Wang Pingzhen,Andrews Robert Carl,Ren Tan. Владелец: HIGH POINT PHARMACEUTICALS, LLC. Дата публикации: 2012-04-26.

SUBSTITUTED HYDROXYETHYL AMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE

Номер патента: US20120220583A1. Автор: . Владелец: Amgen Inc.. Дата публикации: 2012-08-30.

Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use

Номер патента: US20120329830A1. Автор: Brown James,ZHONG Wenge,Lopez Patricia,Xue Qiufen,Cheng Yuan,JR. David J.,Paras Nick A.,Powers Timothy,Hitchcock Stephen A.,Judd Ted,Nixey Thomas,Harried Scott,ASHTON Kate,St. Jean,Poon Steve F.. Владелец: Amgen Inc.. Дата публикации: 2012-12-27.

Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use

Номер патента: US20130018064A1. Автор: Brown James,Lopez Patricia,Xue Qiufen,Yang Bryant,Cheng Yuan,Paras Nick A.,Powers Timothy,Hitchcock Stephen A.,Judd Ted. Владелец: Amgen Inc.. Дата публикации: 2013-01-17.

Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use

Номер патента: US20130040931A1. Автор: Brown James,ZHONG Wenge,Lopez Patricia,Xue Qiufen,Yang Bryant,Cheng Yuan,Minatti Ana Elena,Paras Nick A.,Powers Timothy,Hitchcock Stephen A.,Judd Ted,Tegley Christopher M.,Nixey Thomas. Владелец: Amgen Inc.. Дата публикации: 2013-02-14.

(3,4-phenyl)piperidin-3-yl- phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of alzheimer's disease

Номер патента: CN1863530A. Автор: S·R·普利,D·L·布朗,J·B·穆恩,V·约翰,D·H·里奇,B·杰戈德因斯卡,J·S·雅各布斯. Владелец: Pharmacia and Upjohn Co LLC. Дата публикации: 2006-11-15.

siRNA Targeting Beta Secretase (BACE)

Номер патента: US20130023446A1. Автор: Leake Devin,Khvorova Anastasia,Reynolds Angela,Marshall William,Read Steven,Scaringe Stephen. Владелец: DHARMACON, INC.. Дата публикации: 2013-01-24.

Substituted isoindoles as bace inhibitors and use thereof

Номер патента: RU2446158C2. Автор: Анника КЕРС,Стефан БЕРГ,Джеймс АРНОЛЬД,Дидье РОТТИЧЧИ,Джанни ЧЕССАРИ,Майлз КОНГРИВ,Фил ЭДВАРДЗ,Йёрг ХОЛЕНЗ,Карин КОЛМОДИН,Кристофер МЮРРЭЙ,Сахил ПЭЙТЕЛ,Ласзло РАКОС,Марк СИЛЬВЕСТЕР,Лиселотте ЭБЕРГ,Стефан БЕРГ (SE),Дидье РОТТИЧЧИ (SE),Анника КЕРС (SE),Карин КОЛМОДИН (SE),Кристофер МЮРРЭЙ (GB),Джеймс АРНОЛЬД (US),Джанни ЧЕССАРИ (GB),Майлз КОНГРИВ (GB),Фил ЭДВАРДЗ (US),Йёрг ХОЛЕНЗ (SE),Сахил ПЭЙТЕЛ (GB),Ласзло РАКОС (SE),Марк СИЛЬВЕСТЕР (US),Лиселотте ЭБЕРГ (SE). Владелец: Астразенека Аб. Дата публикации: 2012-03-27.

สารอนุพันธ์ออกซาซีน (oxazine derivatives) และ การใช้ของสารนั้นในฐานะตัวยับยั้ง BACE (BACE inhibitor) สำหรับการบำบัดของความผิดปกติทางประสาทวิทยา

Номер патента: TH125170B. Автор: นายมูราลี เชบรอลู นายแมทธีอัส เฟรเดอริกเซ่น นายฟิลิปป์ โฮลเซอร์ นางสาวคอนสแตนซ์ เฮิร์ธ นายไรเนอร์ มาร์-ติน ลูเอนด์ นายไรเนอร์ มาเชาเออร์ นายเฮนริก โมบิทซ์ นายอูลฟ์ นิวมานน์ นางสาวริต้า รามอส นายเฮนริคช์ รูเกอร์ นางสาวมารินา ทินเทลน๊อต-บลอมเลย์ นายเซียม เจคอบ วีนสตรา นายซันกาเมช บาดิเกอร์. Владелец: โนวาร์ทิส เอจี. Дата публикации: 2013-07-05.

Compounds and their use as BACE inhibitors

Номер патента: US20120165346A1. Автор: Karlstrom Sofia,Kolmodin Karin,LINDSTROM Johan,SWAHN Britt-Marie,VON BERG Stefan,Kihlström Jacob,Sundström Marie. Владелец: AstraZeneca AB. Дата публикации: 2012-06-28.

IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE

Номер патента: US20120183563A1. Автор: Li Guoqing,Stamford Andrew W.,Scott Jack D.,Gilbert Eric J.,Cumming Jared N.,Iserloh Ulrich,Misiaszek Jeffrey A.. Владелец: . Дата публикации: 2012-07-19.

IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

Номер патента: US20120189642A1. Автор: Li Wei,Stamford Andrew W.,Scott Jack D.,Gilbert Eric J.,Cumming Jared N.,Iserloh Ulrich,Wang Lingyan. Владелец: Schering Corporation. Дата публикации: 2012-07-26.

BACE INHIBITORS

Номер патента: US20120323001A1. Автор: . Владелец: ELI LILLY AND COMPANY. Дата публикации: 2012-12-20.

Substituted isoindoles as bace inhibitors and use thereof

Номер патента: RU2446158C9. Автор: Анника КЕРС,Стефан БЕРГ,Джеймс АРНОЛЬД,Дидье РОТТИЧЧИ,Джанни ЧЕССАРИ,Майлз КОНГРИВ,Фил ЭДВАРДЗ,Йёрг ХОЛЕНЗ,Карин КОЛМОДИН,Кристофер МЮРРЭЙ,Сахил ПЭЙТЕЛ,Ласзло РАКОС,Марк СИЛЬВЕСТЕР,Лиселотте ЭБЕРГ. Владелец: Астразенека Аб. Дата публикации: 2012-06-20.

Oxazine derivatives and their use as BACE inhibitors for the treatment of neurological disorders

Номер патента: AU2013273640A1. Автор: Marina Tintelnot-Blomley,Rita Ramos,Michael Schaefer,Sangamesh Badiger,Murali Chebrolu,Konstanze Hurth,Rainer Martin Lueoend,Rainer Machauer,Heinrich Rueeger,Siem Jacob Veenstra,Markus Voegtle,Ulf Neumann,Henrik Moebitz,Mathias Frederiksen,Philipp Hölzer. Владелец: NOVARTIS AG. Дата публикации: 2014-01-16.

Oxazine derivatives and their use as bace inhibitors for the treatment of neurological disorders

Номер патента: UA107356C2. Автор: Marina Tintelnot-Blomley,Rita Ramos,Michael Schaefer,Sangamesh Badiger,Murali Chebrolu,Konstanze Hurth,Rainer Martin Lueoend,Rainer Machauer,Heinrich Rueeger,Siem Jacob Veenstra,Markus Voegtle,Ulf Neumann,Henrik Moebitz,Mathias Frederiksen,Philipp Hölzer. Владелец: NOVARTIS AG. Дата публикации: 2014-12-25.

สารอนุพันธ์ออกซาซีน (oxazine derivatives) และ การใช้ของสารนั้นในฐานะตัวยับยั้ง BACE (BACE inhibitor) สำหรับการบำบัดของความผิดปกติทางประสาทวิทยา

Номер патента: TH125170A. Автор: บาดิเกอร์ นายซันกาเมช,เชบรอลู นายมูราลี,เฟรเดอริกเซ่น นายแมทธีอัส,โฮลเซอร์ นายฟิลิปป์,เฮิร์ธ นางสาวคอนสแตนซ์,มาร์-ติน ลูเอนด์ นายไรเนอร์,มาเชาเออร์ นายไรเนอร์,โมบิทซ์ นายเฮนริก,นิวมานน์ นายอูลฟ์,รามอส นางสาวริต้า,รูเกอร์ นายเฮนริคช์,ทินเทลน๊อต-บลอมเลย์ นางสาวมารินา,เจคอบ วีนสตรา นายเซียม,เวกท์ลี นายมาร์คัส,เชฟเฟอร์ นายไมเคิล. Владелец: นายณัฐพล อร่ามเมือง. Дата публикации: 2013-07-05.

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