Imidazo [1, 2 -a] pyrazine derivatives and their use for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases .

Imidazo [1, 2 -a] pyrazine derivatives and their use for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases

Номер патента: WO2011110545A1
Опубликовано: 15-09-2011
Автор(ы): Gregor James Macdonald, Greta Constantia Peter Vanhoof, Joaquin Pastor-Fernández, José Manuel Bartolomé-Nebreda, María Luz Martín-Martín, Michiel Luc Maria Van Gool, Susana Conde-Ceide
Принадлежит: Janssen Pharmaceutica NV
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Рисунок 1. Взаимосвязь патентов (ближайшие 20).

Aminonorbornane derivative and manufacture method therefor and use thereof

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1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders

Номер патента: MY161325A. Автор: Gregor James Macdonald,Daniel Oehlrich,Gary John Tresadern,Andrés Avelino Trabanco-Suárez,José Maria CID-NÚÑEZ,Ramiro Juan Antonio Vega. Владелец: Addex Pharmaceuticals SA. Дата публикации: 2017-04-14.

N-(phenyl)-2-[[3-(phenyl)-1H-1,2,4-triazol-5-yl]thio]-acetamide derivatives and related compounds as G protein coupled receptor 17 (GPCR17) modulators for use in the treatment of neuro-degenerative diseases

Номер патента: EP2850068B1. Автор: Paola Zaratin,Maria Pia Abbracchio,Mario Alberto BATTAGLIA,Ivano Eberini,Marta FUMAGALLI,Chiara Parravicini,Cristina SENSI. Владелец: FOND ITALIANA SCLEROSI MULTIPLA FISM ONLUS. Дата публикации: 2019-05-29.

Imidazo[1,2-a]pyrazin-1yl-benzamide compounds for treating spinal muscular atrophy

Номер патента: CA2952895C. Автор: Emmanuel Pinard,Luke Green,Hasane Ratni,Patrick Williamson. Владелец: F Hoffmann La Roche AG. Дата публикации: 2023-09-26.

6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Номер патента: US20170217972A1. Автор: Trabanco-Suárez Andrés Avelino,Andrés-Gil José Ignacio,Maria,Van Gool Michiel Luc,Alonso-de Diego Sergio-Alvar,Delgado-González Óscar. Владелец: Janssen Pharmaceutica NV. Дата публикации: 2017-08-03.

Use of sodium salt of diethyl ester of 4-oxo-1,4-dihydropyrazolo[5,1-c]-1,2,4-triazine-3,8-dicarboxylic acid, monohydrate as drug for treatment and prevention of late complications of diabetes mellitus

Номер патента: RU2765117C2. Автор: Владимир Иванович Петров,Владимир Леонидович Русинов,Светлана Константиновна Котовская,Ирина Михайловна Сапожникова,Александр Алексеевич Спасов,Алексей Владимирович Смирнов,Валентина Андреевна Бабкова,Юлия Александровна Говорова,Наталия Алексеевна Гурова,Роман Александрович Литвинов,Людмила Владимировна Науменко,Максим Вячеславович Шмидт. Владелец: федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации. Дата публикации: 2022-01-25.

6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors

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IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

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New process for the synthesis of 5-{5-chloro-2-[(3s)-3- [(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h )-carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds

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New process for the synthesis of 5-{5-chloro-2-[(3s)-3- [(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds

Номер патента: CA3214107A1. Автор: Frederic Pin,Bálint PETHÖ. Владелец: Laboratoires Servier SAS. Дата публикации: 2022-09-29.

Tablet formulation of 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Номер патента: NZ728089B2. Автор: Shau Fong Yen,Zhixin Zong,Elisabete Goncalves,Sudha Vippagunta,Christin Tauchmann. Владелец: NOVARTIS AG. Дата публикации: 2024-04-30.

Tablet formulation of 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Номер патента: MY187276A. Автор: Zhixin Zong,Elisabete Goncalves,Sudha Vippagunta,Shau-Fong Yen,Christin Tauchmann. Владелец: NOVARTIS AG. Дата публикации: 2021-09-17.

Tablet formulation of 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Номер патента: NZ728089A. Автор: Zhixin Zong,Elisabete Goncalves,Sudha Vippagunta,Shau-Fong Yen,Christin Tauchmann. Владелец: NOVARTIS AG. Дата публикации: 2024-01-26.

1,2,4-Triazolo [4,3-A] Pyridine Derivatives and Their Use For The Treatment of Prevention of Neurological and Psychiatric Disorders

Номер патента: US20160067245A1. Автор: Gregor James Macdonald,Daniel Oehlrich,Gary John Tresadern,Andrés Avelino Trabanco-Suárez,José Maria CID-NÚÑEZ,Juan Antonio Vega Ramiro. Владелец: Addex Pharmaceuticals SA. Дата публикации: 2016-03-10.

1,2,4-Triazolo [4,3-A] Pyridine Derivatives And Their Use For The Treatment Of Prevention Of Neurological And Psychiatric Disorders

Номер патента: US20170333426A1. Автор: Trabanco-Suárez Andrés Avelino,Tresadern Gary John,Vega Ramiro Juan Antonio,CID-NUNEZ Jose Maria,Oehlrich Daniel,MACDONOLD Gregor James. Владелец: . Дата публикации: 2017-11-23.

1,2,3-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders

Номер патента: CN102439008B. Автор: 安德烈斯·阿韦利诺·特拉班科-苏亚雷斯,加里·约翰·特雷萨德尔恩,胡安·安东尼奥·维加拉米罗,乔斯·玛丽亚·锡德-努涅斯,丹尼尔·奥尔里希,格雷戈尔·詹姆斯·麦克唐纳. Владелец: Addex Pharmaceuticals SA. Дата публикации: 2015-04-29.

Imidazo[1,2-a]pyridine derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto

Номер патента: US20190142826A1. Автор: REN Albert S,Yifeng Xiong,Brett Ullman,Konrad Feichtinger. Владелец: Arena Pharmaceuticals Inc. Дата публикации: 2019-05-16.

Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto

Номер патента: US9567327B2. Автор: Yifeng Xiong,Albert S. Ren,Brett Ullman,Konrad Feichtinger. Владелец: Arena Pharmaceuticals Inc. Дата публикации: 2017-02-14.

Imidazo[1,2-a]pyridine derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto

Номер патента: EP2190844B3. Автор: Yifeng Xiong,Albert S. Ren,Konrad Feichtinger,Brett Ulmann. Владелец: Arena Pharmaceuticals Inc. Дата публикации: 2013-07-17.

1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Номер патента: US20140155393A1. Автор: Trabanco-Suárez Andrés Avelino,Tresadern Gary John,MacDonald Gregor James,Vega Ramiro Juan Antonio,CID-NUNEZ Jose Maria,Oehlrich Daniel. Владелец: JANSSEN PHARMACEUTICALS, INC.. Дата публикации: 2014-06-05.

1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors

Номер патента: AU2011328203B2. Автор: Gregor James Macdonald,Daniel Oehlrich,Gary John Tresadern,Andrés Avelino Trabanco-Suárez,José Maria CID-NÚÑEZ,Juan Antonio Vega Ramiro. Владелец: Janssen Pharmaceuticals Inc. Дата публикации: 2015-03-19.

1,2,4-triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors

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1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors

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NEW SUBSTITUTES OF SUBSTITUTED MORPHOLINE DERIVATIVES 2, 3-DIHYDRO-1H-IMIDAZO {1, 2-a} PYRIMIDIN-5-ONA AND 1, 2, 3, 4-TETHRHYDROPYRIMIDO {1, 2-a} PYRIMIDIN-I-6-Pyrimidine-6 OBTAINING AND THEIR PHARMACEUTICAL APPLICATION

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7-phenoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma-secretase modulators for the treatment of alzheimer's disease

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pharmaceutical composition; method for treating or prophylaxis of a viral infection or disease associated therewith; compound; a method for preparing a mixture of tert-butyl (4e) -4- (hydroxymethylene) -5-oxoazepane-1-carboxylate and tert-butyl (3e) -3- (hydroxymethylene) -4-oxoazepane-1-carboxylate; method for the preparation of a mixture of tert-butyl 3-cyano-2-thioxo-1,2,5,6,8,9-hexahydro-1h-pyrido [2,3-d] azepine-7-carboxylate and tert butyl 3-cyano-2-thioxo-1,2,5,7,8,9-hexahydro-6h-pyrido [3,2-c] azepine-6-carboxylate; Method for the preparation of 3-amino-7-tert-butyloxycarbonyl-6,7,8,9-tetrahydro-5h-1-thia-7,10-diaza-cyclohepta [f] indene-2-carboxylic acid (5- phenyl- [1,3,4] thiazol-2-yl) -amide; method for the preparation of 3-amino-6,7,8,9-tetrahydro-5h-1-thia-7,10-diaza-cyclohepta [f] indene-2-carboxylic acid (5-phenyl- [1,3 , 4] thiadiazol-2-yl) -amide; Method for the preparation of 3-amino-6-tertbutyloxycarbonyl-6,7,8,9-tetrahydro-5h-1-thia-6,10-diaza-cyclohepta [f] indene-2-carboxylic acid [1,3,4] thiadiazol-2-yl) -amide and method for the preparation of 3-amino-6,7,8,9-tetrahydro-5h-1-thia-6,10-diaza-cyclohepta acid [ f] indene-2-carboxylic (5-phenyl- [1,3,4] thiadiazol-2-yl) -amide

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Compounds for their use as drugs for the treatment and/or the prevention of infection(s) caused by biofilm-forming bacteria

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Compounds for their use as drugs for the treatment and/or the prevention of infection(s) caused by biofilm-forming bacteria

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Compounds for their use as drugs for the treatment and/or the prevention of infection(s) caused by biofilm-forming bacteria

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Imidazo[1,2-b]pyridazine based tricyclic compounds as inhibitors of haspin and therapeutic uses thereof

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Imidazo[1,2-b]pyridazine based tricyclic compounds as inhibitors of haspin and therapeutic uses thereof

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Process for the preparation of 4-(3,5-difluorophenyl)-N-[3-(6-methylpyrimidin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl]-6,7-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine

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Novel 5-cyano-prostacyclin derivatives and their use as agents for the treatment of autoimmune diseases

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(1-ALCOXY 2-AMINO) ETHYL PYRIDINE OR PYRAZINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

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3-(4-Piperidinyl)-1,2-benzisothiazoles and derivatives, a process for their preparation and their use as medicaments

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3- (CYCLOPENTEN-1YL) -BENZYL-OU3- (CYCLOPENTEN-1YL) -HETEROARYLMETHYL-AMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF SCHIZOPHRENIA

Номер патента: FR2845992B1. Автор: Francis Colpaert,Wouter Koek,Bernard Vacher,Stephane Cuisiat. Владелец: Pierre Fabre Medicament SA. Дата публикации: 2005-02-04.

Substituted [1,2,4]triazolo[4,3-A]pyridines, their preparation and their use as pharmaceuticals

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Novel rhodanine derivatives and uses thereof

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Hmg-coa reductase inhibitors and their use as medicaments for the treatment of cholesterol related diseases

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8-methoxy-(1,2,4)triazolo(1,5-a)pyridine derivatives and their use as adenosine receptor ligands

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4-aryl-1-nicotinoylpiperazine derivatives, process for their preparation and their use in and for the preparation of therapeutic preparations

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8-methoxy-(1,2,4)triazolo(1,5-a)pyridine derivatives and their use as adenosine receptor ligands

Номер патента: WO2003010167A1. Автор: Matthias Heinrich Nettekoven,Bernd Puellmann. Владелец: F. Hoffmann-La Roche AG. Дата публикации: 2003-02-06.

Substituted hexahydropyrrolo(1,2-a)-quinoline, hexahydro-1h-pyrido(1,2-a)-quinoline, hexahydrobenzo (e)-indene and octahydrophenanthrene and their composition

Номер патента: JPS58170724A. Автор: ジエ−ムズ・フレデリツク・エツグラ−,マイケル・ロス・ジヨンソン,ロ−レンス・シヤ−マン・メルヴイン・ジユニア−. Владелец: PFIZER INC. Дата публикации: 1983-10-07.

Quinoline-2-one-derivatives for the treatment of airways diseases

Номер патента: CA2521271C. Автор: Ian Bruce,Neil John Press,Simon James Watson,Robin Alec Fairhurst,David Andrew Sandham,Bernard Cuenoud,Roger John Taylor,David Beattie,Reamonn Madden,Katharine Louise Turner. Владелец: NOVARTIS AG. Дата публикации: 2011-01-04.

Hmg-coa reductase inhibitors and their use as medicaments for the treatment of cholesterol related diseases

Номер патента: WO2001096311A2. Автор: Bang-Chi Chen,Jeffrey A. Robl,Chong-Qing Sun. Владелец: BRISTOL-MYERS SQUIBB COMPANY. Дата публикации: 2001-12-20.

Scopine salts and their use in processes for the preparation of n-demethyl-tiotropium and tiotropium bromide

Номер патента: WO2008008376A8. Автор: Francesca Scarpitta,Jonathan Busolli,Nicola Diulgheroff,Alessandro Pontiroli,Roberta Volonte. Владелец: Roberta Volonte. Дата публикации: 2008-03-27.

Scopine salts and their use in processes for the preparation of n-demethyl-tiotropium and tiotropium bromide

Номер патента: WO2008008376A2. Автор: Francesca Scarpitta,Jonathan Busolli,Nicola Diulgheroff,Alessandro Pontiroli,Roberta Volonte. Владелец: SICOR INC.. Дата публикации: 2008-01-17.

Scopine salts and their use in processes for the preparation of n-demethyl-tiotropium and tiotropium bromide

Номер патента: WO2008008376A3. Автор: Francesca Scarpitta,Jonathan Busolli,Nicola Diulgheroff,Alessandro Pontiroli,Roberta Volonte. Владелец: Roberta Volonte. Дата публикации: 2008-11-13.

Spiro-1,2,4-trioxanes

Номер патента: US7495025B2. Автор: Chandan Singh,Sunil Kumar Puri,Heetika Malik. Владелец: Council of Scientific and Industrial Research CSIR. Дата публикации: 2009-02-24.

Novel spiro-1,2,4-trioxanes

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Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor

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DERIVATIVES OF 3- (1,2-BENZISOXAZOL-3-YL) OXAZOLIDIN-2-ONE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

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PYRANONE DERIVATIVES, THEIR PREPARATION METHOD AND THEIR THERAPEUTIC USE, IN PARTICULAR FOR THE TREATMENT OF CANCER

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1,2,4,5-TETRA-ALKYL-4-ARYLPIPERIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

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METHOD FOR THE PRODUCTION OF NEW (1,2-DIHYDRO-2-OXO-NICOTINAMIDO) -ALKYL-BENZOLE-SULFONYL UREAS AND THEIR SALTS

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1- (2-PROPYNYLOXY) -2-AMINO-3-PROPANOL ETHERS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Номер патента: FR2472567A1. Автор: Patrick Carlier,Jacques Simond,Andre Monteil. Владелец: Centre Europeen de Recherches Mauvernay CERM. Дата публикации: 1981-07-03.

Antihypertensive 1,2-benzisothiazole piperidines, a method for synthesizing the same and their use as medicaments

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1,2-dihydro-oxo-amino-3 quinoxaline derivatives, their preparation and their therapeutic use.

Номер патента: FR2696456B1. Автор: Jean-Francois Patoiseau,Jean-Marie Autin,Jean-Pierre Tarayre,Ch Bigg Dennis. Владелец: Pierre Fabre Medicament SA. Дата публикации: 1995-01-06.

Crystalline acid addition salts of diastereomerically pure 1-(2,2-dimethylpropionyloxy)-ethyl-3-cephem-4-carboxylate

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2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes

Номер патента: EP1910350A1. Автор: Darren AstraZeneca R & D Alderley MCKERRECHER,Kurt Gordon AstraZeneca R & D Alderley PIKE,Michael James AstraZeneca R & D Alderley WARING. Владелец: AstraZeneca AB. Дата публикации: 2008-04-16.

Novel 1-<3-(2-hidroxy-3-alkylaminopropoxi)-2-thienyl>-3-phenyl--1-propanones and their salts and a process for the preparation thereof

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Novel 1-<3-(2-hidroxy-3-alkylaminopropoxi)-2-thienyl>-3-phenyl--1-propanones and their salts and a process for the preparation thereof

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2-alkyl-1, 2, 3, 4, 4a, 10b-hexahydro-6-(sulfonamidophenyl)-benzo-(c)-1, 6-naphthyridine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

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Indole-substituted quinolines and their combination with plk1 inhibitors for the treatment of cancer

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4,4-DIFLUOR-1,2,3,4-TETRAHYDRO-5H-1-BENZAZEPINE DERIVATIVES AND THEIR SALTS

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2,3-dihydro-thiazolo[3,2-a]pyridin-5-one derivatives, intermediates thereof, and their use as antibacterial agents

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Benzothiazole derivatives and medicinal products containing them

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Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase

Номер патента: NZ552031A. Автор: Ping Zhou,James Joseph Erdei,Iwan Suwandi Gunawan,Michael Sotirios Malamas,Yinfa Yan,Dominick Quagliato. Владелец: Wyeth Corp. Дата публикации: 2009-06-26.

1-(2-(4-cyclopropyl-1h-1,2,3-triazol-1-yl)acetyl)-4-hydroxypyrrolidine-2-carboxa|mide derivatives as vhl inhibitors for the treatment of anemia

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9-HYDRAZONO-6,7,8,9-TETRAHYDRO-4H-PYRIDO / 1,2-A / PYRI-MIDIN-4-ON DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF.

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1-[2-(heterocyclyl-aminomethyl)-piperidin-1-YL]-1-(2-methyl-5-phenyl-heterocyclyl)-methanone derivatives and related compounds as orexin-1 antagonists for the treatment of obesity

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Novel s-timolol derivative and process for its preparation

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Crystalline forms of (1s)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol

Номер патента: WO2014074940A1. Автор: YING Chen,Jinkun Huang,Robert Farrell,Helming Tan,Indrani W. Gunawardana,Jonathan W. Lane,Christopher M Lindemann,Andrew COSBIE,Henry Morrison,Donald T. CORSON,Jason TEDROW,Coralee G. Mannila,Daniel J. Watson,Sylvie ASSELIN,Van Luu,Lisa BRETT,Dennis LEI,Robert MILBURN. Владелец: ARRAY BIOPHARMA INC.. Дата публикации: 2014-05-15.

Crystalline forms of (1s)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol

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1h-pyrrolo[2,3-b]pyridine derivatives and related compounds as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases

Номер патента: WO2020140005A8. Автор: Yi Chen. Владелец: Guangzhou Lupeng Pharmaceutical Company Ltd.. Дата публикации: 2021-05-14.

N-(cyclopropylmethyl)-5-(methylsulfonyl)-n-{1-[1-(pyrimidin-2-yl)-1h-1,2,4-triazol-5-yl]ethyl}benzamide derivatives and the corresponding pyridine-carboxamide derivatives as pesticides

Номер патента: IL298251B1. Автор: . Владелец: Bayer AG. Дата публикации: 2024-10-01.

N-(cyclopropylmethyl)-5-(methylsulfonyl)-n-{1-[1-(pyrimidin-2-yl)-1h-1,2,4-triazol-5-yl]ethyl}benzamide derivatives and the corresponding pyridine-carboxamide derivatives as pesticides

Номер патента: IL298250B1. Автор: . Владелец: Bayer AG. Дата публикации: 2024-09-01.

6- (5 - ((OMEGA) - (1-IMIDAZOLYL) ALKYL) -THIEN-2-YL) -3-OXO-2,3,4,5-TETRAHYDRO-PYRIDAZINE AND THEIR ACID ADDITION SALTS, METHOD FOR THE PRODUCTION THEREOF AND THESE PHARMACEUTICAL PREPARATIONS

Номер патента: DE3130252A1. Автор: Hugo Dr. 5042 Erftstadt Friehe,Gerd Dipl.-Chem.Dr. 5000 Köln Hilboll,Hans-Heiner Dipl.-Chem.Dr. 5024 Pulheim Lautenschläger,Josef Peter Dipl.-Chem.Dr. 4010 Hilden Löhr. Владелец: A Natterman und Cie GmbH. Дата публикации: 1983-02-17.

3-¬2-(azabicyclo)ethyl|-1,2,3,4-tetrahydro-5h- ¬1|benzopyrano¬3,4-c|pyridin-5-ones

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3-¬2-(mono- and dialkylamino)propyl|-1,2,3,4- tetrahydro-5h¬1|-benzopyrano-¬3,4-c| pyridin-5-ones

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Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof and their preparation and uses for inhibiting blood platelet aggregation

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4- (1h-indol-3-yl-methylideneaminoxy-propoxy) -benzioc acid derivatives and related compounds as pai-1 inhibitors for the treatment of impairment of the fibrinolytic system and ofthrombisis

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3- (Indazol-5-yl)-(1,2,4) triazine derivatives and related compounds as protein kinase inhibitors for the treatment of cancer

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PROCESS FOR PREPARING A PREPARATION WITH ANTI-ALLERGIC ACTION BASED ON 1-OXO-1H-PYRIMIDOŸ1,2-AŸ QUINOLINE-2-CARBONIC ACID DERIVATIVES AND PROCESS FOR PREPARING A MEDICINAL COMPOUND SUITABLE FOR USE IN THE PREPARATION OF THE SAID PREPARATION.

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3-(2-(mono-and dialkylamino)-propyl)-1,2,3,4-tetrahydro-5h-(1)-benzopyrano(3,4-c)pyridine-5-ones

Номер патента: NZ203355A. Автор: C F Schwender,D T Connor,P C Unangst,R J Sorenson. Владелец: Warner Lambert Co. Дата публикации: 1985-11-08.

5- (SUBSTITUTED PHENYL) -OXAZOLIDINONES AND THEIR SULFUR ANALOG AND PROCEDURE FOR THE PREPARATION

Номер патента: DK536677A. Автор: A Huth,R Schmiechen,W Kehr,D Palenschat,G Paschelke,H Wachtel,H H Schneider. Владелец: Schering AG. Дата публикации: 1978-06-04.

SUBSTITUTED 3-MERCAPTO-PYRIDAZINE AND THEIR 3-ALKYLTHIODERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Номер патента: DE3310197A1. Автор: Gerrit Dipl.-Chem. Dr. 5024 Pulheim Prop,Harald O. Dipl.-Biol. Dr. 5000 Köln Borbe,Ille-Stephanie 5010 Bergheim-Glessen Doppelfeld,Gerd Dipl.-Chem. Dr. Hilboll. Владелец: A Natterman und Cie GmbH. Дата публикации: 1984-09-27.

Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof and their preparation and uses for inhibiting

Номер патента: KR0148023B1. Автор: 도미오 기무라,데루히꼬 이노우에,히로유끼 고이께,후미또시 아사이,아쓰히로 스기다찌,시게요시 니시노,야스노리 스자끼. Владелец: 나까히가시 모또오. Дата публикации: 1998-08-17.

Substituted sulfonamides as selective .beta.3 agonists for the treatment of diabetes and obesity

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COMPOUNDS DERIVED FROM N-METHYL-C-NORMORFINAN; PHARMACEUTICAL COMPOSITION; AND USE FOR THE REDUCTION OF SECONDARY EFFECTS OF THE TREATMENT OF OPIOIDES SUCH AS CONSTIPATION AND NAUSEAS, AND TO TREAT DISORDERS MEDIATED BY THE ACTIVITY OF RECEPTORS OR

Номер патента: CL2007002272A1. Автор: Syed M Ali Kadum A Kong F Shah. Владелец: Wyeth Corp. Дата публикации: 2008-04-18.

Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof

Номер патента: RS52279B. Автор: Flavio Solca,Frank Himmelsbach,Elke Langkopf,Birgit Jung,Stefan Blech. Владелец: Boehringer Ingelheim Pharma Gmbh & Co.Kg.. Дата публикации: 2012-10-31.

SUBSTITUTED 1,2,3,4,5,6-HEXAHYDRO-2,6-METHANO-3-BENZAZOCINE-10-ì (54) -OLES, METHOD FOR THE PRODUCTION AND USE THEREOF AS M

Номер патента: SK3342000A3. Автор: Matthias Grauert,Adrian Carter,Thomas Weiser,Wolf-Dietrich Bechtel,Rainer Palluk,Uwe Pschorn. Владелец: BOEHRINGER INGELHEIM PHARMA. Дата публикации: 2000-09-12.

4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides, process for their preparation, their use and therapeutic agents containing them.

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Novel derivatives of the oxime of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde,the process for their preparation,their use as medicaments and the compositions containing them

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1-Phenyl-2-heteroaryl-substituted benzimidazole derivatives, the use thereof for the preparation of drugs used in the treatment of immunological diseases

Номер патента: NO20043841L. Автор: Herbert Schneider,Ursula MÖNNING,Bernd Elger,Thorsten Blume,Joachim Kuhnke,Wolfgang Halfbrodt. Владелец: Schering AG. Дата публикации: 2004-11-12.

4-(benzylideneamino)-3-(methylsulfanyl)-4h-1,2,4-triazin-5-one derivatives having a pde iv-inhibiting and tnf-antagonistic action for the treatment of heart diseases and allergies

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1,2-DIHYDROPYRIDO SQUARE CLAMP ON 2.3-S SQUARE CLAMP FOR -AS-TRIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

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Treatment of inflammatory diseases

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Novel cell metabolism modulating compounds and uses thereof for the treatment of viral diseases

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Phosphatase inhibitors as nk cells modulators for the treatment of cancer

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Compositions for use in the prevention and/ or treatment of intellectual disability and neurodegenerative diseases in a subject with down syndrome

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Methods of use of oligosaccharide compositions for modulating microbiota and their metabolic products, and as therapeutics for health applications

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Methods of use of oligosaccharide compositions for modulating microbiota and their metabolic products, and as therapeutics for health applications

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Method for obtaining of supramolecular anthelmintic agent for group treatment of water birds in case of cestodiasis

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Vasoregulating compounds and methods of their use

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Active ingredient consisting of a mixture of polylysine compounds and use in the prevention of strokes and the treatment of the post-stroke inflammatory phase

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Active ingredient consisting of a mixture of polylysine compounds and use in the prevention of strokes and the treatment of the post-stroke inflammatory phase

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Combination of compounds derived from gallic acid for the treatment of cancer

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Pharmaceutical preparation and method for treatment of diabetes

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Pharmaceutical preparation and method for treatment of diabetes

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Pharmaceutical preparation and method for treatment of diabetes

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Pharmaceutical preparation and method for treatment of diabetes

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Pharmaceutical preparation and method for treatment of diabetes

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Use of propionyl L-carnitine for the preparation of a medicament capable of inducing apoptosis

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USE OF A SPECIFIC 5HT2 RECEPTOR ANTAGONIST FOR THE PREPARATION OF MEDICINES USEFUL IN THE TREATMENT OF SLEEP APNEA SYNDROME

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Use of c18 to c26 aliphatic alcohols for the manufacture of a medicament in the treatment of hyperproliferative skin disorders

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Substituted N-(1,2,4-triazol-3-yl)Arylcarboxamide compounds and their use as herbicides

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Pyrazole carboxylic acid amides useful for the reduction of mycotoxin contamination in plants

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Derivatives of 3,6-DI-substituted-1,2,4,5-tetrazine, 3- (2-bromo-phenyl) -6- (2,6-DI-fluoro-phenyl) -1,2,4, 5-tetrazine, 3,6-bis- (2,6-DI.fluoro.fenyl) -1,2,4,5-tetrazine, 3- (2-chloro-phenyl) -6- (2,6-DI -fluoro-phenyl) -1,2,4,5-tetrazine, process for the preparation of derivatives of 3,6-DI-substituted-1,2,4,5-tetrazine, acaricidal, larvicide and ovidically active composition, composition translaminar, oviciously active, composition with transovarian effect and process for reducing the number of mites and their larvae and eggs, process for the preparation of an acaricidal, larvicide and oviciously active composition

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The compounds 6-oxabicylco[3.2.1] octane, 5-methyl-1-(1,2,2-trimethylbicyclo[3.1.0] hex-3-yl)-, 2-oxabicyclo[2,2,2]octane, 1-methyl-4-(1,2,2-trimethylbicyclo[3,1,0] hex-3-yl)-, and their uses in fragrance applications

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N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide compounds as potential anticancer agents and a process for the preparation thereof

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1,2-Dihydro-2-oxoquinol-4-ylacetic acid derivatives and pharmaceutical compositions

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Hydrogel formulations for use in the prevention and treatment of gingival infections and dental caries

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Herbicidal mixtures comprising l-glufosinate and their use in cotton cultures

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Agent for treatment of wounds, burns and inflammatory skin diseases

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Compositions for use in the treatment of neurological disease

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Compositions for Use in the Treatment of Neurological Disease

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Method for the treatment of chronic adnexitises

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MIXTURE OF PLANT EXTRACTS AND THEIR USES, IN PARTICULAR FOR THE SYMPTOMATIC LOCAL TREATMENT OF LOCALIZED SUBCUTANEOUS ADIPOSE OVERLOADS

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1- methylol -1,2,2,6- tetramethyl-hexamethylene and its derivative and their purposes as aromachemicals

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Gold clusters (AuCs), composition and method for treatment of liver cirrhosis

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GOLD CLUSTERS (AuCs) AND COMPOSITION FOR TREATMENT OF LIVER CIRRHOSIS

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Compositions of Padina algae or their extracts, and their applications in foodstuffs or for the culture of molluscs or arthropodes

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Compositions for oral treatment of warts

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A COMPOSITION BASED ON PROBIOTIC BACTERIA IN ASSOCIATION WITH A PREBIOTIC AND ITS USE IN THE PREVENTION AND / OR IN THE TREATMENT OF PATHOLOGIES AND / OR RESPIRATORY INFECTIONS AND IN THE IMPROVEMENT OF INTESTINAL FUNCTIONALITY.

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Use of a Quinoa extract as active ingredient in a composition containing medium, for the preparation of medicament for non-therapeutic treatment of human body to prevent the formation of new fat in the body

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Process for the preparation of (meth)acrylate di-ammonium salts and their use as monomers for the synthesis of polymers

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Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use

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Alkaloid derivatives and methods of their use

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Process for the preparation of (meth)acrylate di-ammonium salts and their use as monomers for the synthesis of polymers

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Process for the preparation of intermediates useful in the treatment of hiv infection

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Process for preparing 1-hydroxy-3-oxa-1,2,4,5-pentane tetracarboxylic acid and 3,6-dioxa-1,2,4,5,7,8-octane hexacarboxylic acid mixtures and their alkali metal derivatives

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Alkaloid derivatives and methods of their use

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Devices, systems, and their methods of use for desktop evaluation

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Method of surgical treatment of patients with tumor involvement of duodenum

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9H-Imidazo[1,2-a]benzimidazole-3-acetamide derivatives, their preparation and their application in therapeutics

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9H-imidazo [1,2-a] benzimidazole-3-acetamide derivatives, their preparation and their therapeutic use.

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9H-imidazo [1,2-a] benzimidazole-3-acetamide derivatives, their preparation and their therapeutic use.

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Bladder event detection for diagnosis of urinary incontinence or treatment of lower urinary tract dysfunction

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Method of surgical treatment of children with legg-calvé-perthes disease

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Method of surgical treatment of patients with tumor involvement of duodenum

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IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

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IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

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IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

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6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

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IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

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Method for selecting treatment of cerebral metastases in patients with triple-negative breast cancer and metastatic involvement of parenchymal organs

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Method for removal of central retinal fold after surgical treatment of extensive traumatic retinal detachment

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Bladder event detection for diagnosis of urinary incontinence or treatment of lower urinary tract dysfunction

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Method of treatment of macular for age-related macular degeneration

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Method for treatment of biliary dyskinesia in hyperkinetic and hypokinetic types using a physiotherapeutic method and device for influencing the gallbladder and bile ducts

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Method for predicting the result of laser treatment of a hypertrophic scar in women

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Method for surgical treatment of pyoinflammatory processes of bone and soft tissue structures of the patient's locomotor system using soft spacers impregnated with an aminoglycoside and a glycopeptide

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PYRAZINO [1,2-A] INDOLE-1-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

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METABOLITES OF 2-(FURAN-2-YL)-7-(2-(4-(4-(2-METHOXYETHOXY)PHENYL)PIPERAZIN-1-YL)ETHYL)-7H-PYRAZOLO[4,3-e][1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-5-AMINE AND THEIR UTILITY AS ADENOSINE A2a RECEPTOR ANTAGONISTS

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7-PHENOXY-N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)-6,7-DIHYDRO-5H-PYRROLO[1,2-B][1,2,4]TRIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

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Ophthalmologic apparatus and method for the observation, examination, diagnosis, and/or treatment of an eye

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Ophthalmologic apparatus and method for the observation, examination, diagnosis, and/or treatment of an eye

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Implantable correctant of a spinal curvature and a method for treatment of a spinal curvature

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Arrangement for the oct-based laser vitreolysis

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DEVICE FOR THE PLACEMENT OF A PROSTHESIS IN THE TREATMENT OF HERNIA OF THE GROWTH BY COELIOSCOPIC ROUTE

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Screening method for the composition for prevention or treatment of osteoporosis and metabolic bone disease using TALLYHO/JngJ mouse

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Shaped articles which comprise active compounds and are based on biologically degradable, thermoplastically processable polymers, processes for their production and their use

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PROCESS FOR THE ELIMINATION OF SOLID WASTE FROM THE TREATMENT OF MATERIALS OF ANIMAL ORIGIN.

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New monoazo dyestuffs and their metal complexes and processes for the production thereof

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Distribution system for the simultaneous chemical and/or electrolytic surface treatment of at least two substrates

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Materials and methods for the identification of drug-resistant cancers and treatment of same

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Addition compounds which contain phosphorus and their use as catalysts for the production of foam resins which contain carbodiimide groups

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Five-membered cyclic biscarbonates bearing amide linkages, their preparation and their uses for the preparation of polymers

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Porphyrin derivatives and uses thereof

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Porphyrin derivatives and uses thereof

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Porphyrin derivatives and uses thereof

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Method for producing substituted 5-hydroperoxy-5-alkyl-1,2-dioxolan-3-s

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Catalyst for the preparation of polyurethanes

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Catalyst for the preparation of polyurethanes

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2-phenylsulphinyl-nitro-pyridines, and their use as fungicides

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Coumarin derivatives, and processes for their preparation

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Process for the production of basic triphenylalkene derivatives

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Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions

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Azide Substituted Naphthylene or Rylene Imide Derivatives and their Use as Reagents in Click-Reactions

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Azide Substituted Naphthylene or Rylene Imide Derivatives and their Use as Reagents in Click-Reactions

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Methoxyamine derivatives and their salts and their uses and processes for the preparation thereof

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Method of producing 2,3-dialkyl-n-phenyl-1,2,3,4-tetrahydroquinoline-4-amines

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Compositions of biologically active menaquinol derivatives and methods of treatment

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Fluoromethylated alkenols and their dehydration products and processes for the preparation of these compounds and their use

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Catalyst for the preparation of polyurethanes

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Process for the preparation of high purity Levosimendan

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Process for the preparation of high purity levosimendan

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Process for the preparation of high purity levosimendan

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New 1,1-dioxo-1,2-benzoisothiazol-3-one derivatives, process for their preparation and their application as medicaments

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PHOTOLABILE PROTECTIVE GROUPING COUPLING AGENTS AND THEIR USES, IN PARTICULAR FOR THE FUNCTIONALIZATION OF SOLID SUPPORTS

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Process for the preparation of new 1-alkyl-1,2,5,6-tetrahydro-3-pyridylmethyl-carboxylic acid esters and their acid addition salts and quaternary ammonium compounds

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一种1,1′-乙撑-2,2′-联吡啶二氯盐的制备方法

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4-2-dimethylamino-1-1-hydroxycyclohexylethylphenoxy derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for the the prevention and treatment of central nervous system disease containing the same as an active ingredient

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Novel(1,2,3,4,5,6h)-triazine-2,4-diones, their preparationand their use insecticides

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NEW PHOSPHORIC ESTERS DERIVED FROM 1,2,4-TRIAZOLE WITH INSECTICIDE, NEMATOCIDE AND ACARICIDE PROPERTIES AND THEIR PREPARATION PROCESS

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ACYLATED DERIVATIVES OF IH-1,2,4-TRIAZOLE, THEIR USE AND METHOD FOR THE SYNTHESIS OF SAID DERIVATIVES.

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Method for preparing non-toxic salt of 6-methyl-3,4-dihydro-1,2,3-oxathiazine-4-one-2,2-dioxide and apparatus for performing the method (PROCESS FOR THE PREPARATION OF THE NON-TOXIC SALTS OF 6-METHYL-3,4-DIHYDRO-1,2,3-OXATHIAZIN-4-ONE-2,2-DIOXIDE AND ARRANGEMENT FOR CARRYING OUT THIS PROCESS)

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2 Styrylquinazole indenvates and their acid addition products, processes for the manufacture of such substances and the medicinal products made from them

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3-TRICHLOROMETHYL-5- (CYCLIC AMINE) -1,2,4-THIADIAZOLE, FERTILIZER COMPOSITION CONTAINING THESE SELECTED COMPOUNDS AND THEIR APPLICATION FOR INHIBITING NITRIFICATION OF AMMONIACAL NITROGEN

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NOVEL 2-ISOPROPYL PYRIDO (2-1-B) QUINAZOLINES AND THEIR NON-TOXIC SALTS, PROCESS FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

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Derivatives of 9-oxo-15-hydroxyprostanoic acid and their homologues and a process for the preparation of these compounds

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Blood platelet aggregation inhibitory 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid derivatives and salts thereof; pharmaceutical compositions thereof; and analogy processes for the manufacture thereof

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NEW TRIFLUOROMETHYL-3-ARYL-4 AMINO-5 PYRAZOLES AND THEIR APPLICATION AS DIAZOTABLE BASES FOR THE SYNTHESIS OF COLORING MATTERS

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4-(benzylidene-amino)-3-(methylsulfanyl)-4H-1,2,4-triazin-5-one derivatives having a PDE IV-inhibiting and TNF-antagonistic action for the treatment of heart diseases and allergies.

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Process for the preparation of (meth)acrylate di-ammonium salts and their use as monomers for the synthesis of polymers

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Process for the manufacture of fluoranthene derivatives

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ETERAMINE OXIDES, THE PROCEDURE FOR THEIR PREPARATION AND THEIR USE AS TENSIDES FOR THE TERTIARY OIL EXTRACTION.

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1,2,3-triazolyl derivatives of phosphoric acids their preparation and their use as insecticides acaricides and nematicides

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一种2-乙酰王百合苷a对照品的制备方法

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2-Substituted bisindenyl-metallocenes, process for their preparation and their use as catalysts for the polymerization of olefins

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Metallocene compounds, process for their preparation, and their use in catalysts for the polymerization of olefins

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Metallocene compounds, process for their preparation, and their use in catalysts for the polymerization of olefins

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Bridge prosthesis for treatment of dento-alveolar lengthening

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Bifidobacterium pseudocatenulatum ov-17 strain, used for making bacterial preparations, bioligically active additives to food, fermented and unfermented food products, hygienic and cosmetic agents

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Номер патента: US20120184527A1. Автор: Trabanco-Suárez Andrés Avelino,MacDonald Gregor James,Cic-Nunez Jose Maria,De Lucas Olivares Ana Isabel. Владелец: . Дата публикации: 2012-07-19.

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Pharmaceutical composition based on intercellular adhesion mediator (variants), method of inhibition of intercellular adhesion, method of treatment of patients with inflammatory disease, method of analysis of the test-compound with respect to its capability to inhibit intercellular adhesion, method of compound synthesis

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METHOD FOR PRODUCING NEW PYRIDO- (1,2-A) PYRIMIDINE DERIVATIVES, THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, AND THEIR SOLVATES, STEREOISOMERS AND TAUTOMERS

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Process for the preparation of immunological preparations useful in testing, the prevention against and/or the treatment of infections by candida guilliermondii

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Treatment of dinitronaphthalene

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PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OF SIBERIAN ANALYSIS AND TREATMENT OF ANTOMOSIS AND HELMINTOSIS IN RUMENTAL ANIMALS

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Octahydrobenzo(6,7)cyclohepta(1,2,3-d,a)pyrido(or pyrrolo)-(2,1-a)isoquinolines and decahydrobenzo-(6,7)cyclohepta-(1,2,3-d,e)azepino(2,1-a)isoquinolines and their preparation

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Composition containing bacterial waste products useful for human body

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Imidazo [1, 2 -a] pyrazine derivatives and their use for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases

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