СИСТЕМА, СПОСОБ И УСТРОЙСТВО ДЛЯ ВМЕШАТЕЛЬСТВА НА СЕРДЦЕ С МАГНИТНО-РЕЗОНАНСНОЙ (MR) ДИАГНОСТИКОЙ ИНСУЛЬТА И ЕГО ЛЕЧЕНИЕМ

... 1. Магнитно-резонансная система (20) для выполнения катетерной процедуры (230) под контролем магнитно-резонансной визуализации, при этом система содержит:память (32) последовательностей для хранения, по меньшей мере, последовательности магнитно-резонансной ангиографии, последовательности 3-мерной диффузионно-взвешенной визуализации и последовательности 3-мерной перфузионно-взвешенной визуализации;контроллер (30) последовательностей для выполнения множества последовательностей 3-мерной визуализации; ипроцессор (36), запрограммированный управлять магнитно-резонансной системой (20) для осуществления этапов:выполнения, по меньшей мере, одной из последовательности 3-мерной диффузионно-взвешенной визуализации и последовательности 3-мерной перфузионно-взвешенной визуализации, чтобы сформировать, по меньшей мере, одно из первого 3-мерного диффузионно-взвешенного изображения головы субъекта и первого 3-мерного перфузионно-взвешенного изображения головы субъекта, перед началом катетерной процедуры ...

СИСТЕМА И СПОСОБ ДЛЯ ДИАГНОСТИКИ НАРУШЕНИЙ ДЕЯТЕЛЬНОСТИ СТВОЛА ГОЛОВНОГО МОЗГА

... 1. Способ выявления нарушений деятельности ствола головного мозга у субъекта (4), содержащий этапы, на которых:выявляют реакцию субъекта на звуки, причем формируют звуковые раздражители, передают звуковые раздражители субъекту,регистрируют электрофизиологическую активность мозга субъекта посредством элементов, прикрепленных к субъекту, при этом упомянутые звуковые раздражители имеют заранее заданные физические свойства по частоте, времени и амплитуде,запускают упомянутую регистрацию электрофизиологической активности мозга субъекта одновременно с тем, как упомянутые звуковые раздражители передаются субъекту, исравнивают реакции ствола головного мозга из упомянутой запущенной регистрации активности головного мозга с нормализованными реакциями из образцовой популяции, и определяют наличие нарушения деятельности ствола головного мозга у субъекта, если реакции ствола головного мозга субъекта отклоняются от таковых у образцовой популяции.2. Способ по п.1, дополнительно содержащий этапы, на которых ...

Device to determine visuo-spatial ability

The device (10) disclosed herein assists in the diagnosis and classification of neurodegenerative diseases through the assessment of a subject's visuo-spatiai ability, The device (10) has a touch-screen display (11) into which a user can input data utilising a stylus (13) or the like. A position reader is provided, linked to a position data storage means and also a timer to link a time value to said position data, the time value being stored in a time data storage means. Storage means is also provided for preset-value data relating to known data on medical conditions, with the preset-value data having been produced in accordance with an evolutionary algorithm. A comparator compares the user input data with the preset-value data, and the result is output.

An EEG signal processor, and associated methods

Olfactory bulb (OB) function is measured using an electro-bulbogram (EBG). EEG signals representative of electrical activity in a participant's brain for a period of time following exposure to an odour are measured, and EEG power data at frequencies greater than 25Hz, ideally in the range 25-100Hz, are determined to provide an indicator of the olfactory bulb (OB) function. A singe EEG system may be used to measure signals relating to both OBs, or separate systems 502, 512 may be used for the left and right OBs. The determined olfactory bulb function may be used as an early indication of neurological disease such as Parkinson’s disease. A Parkinson’s disease indicator 560 may be provided based on the difference between an indicator of left OB function 510a and right OB function 510b.

PARTIAL ONE AORTENOKKLUSIONSVORRICHTUNG FOR THE INCREASE THE ZELEBRALEN BLOOD CIRCULATION

Tragbare Sendervorrichtung zum Signalisieren eines Zustands eines Benutzers

An embodiment of the invention discloses a portable transmitter device (102) containing: a sensor designed to emit a sensor signal (114); and a signaling unit (112) designed to determine, from the sensor signal, the presence of a defined state (for example an emergency or fall) of a user of the transmitter device (102). The signaling unit (112) is further designed to transmit, in the event of the presence of a predefined state, a state message (116) (for example an emergency message) to a defined receiving device (104).

Optoacoustic monitoring of blood oxygenation

Systems and methods for monitoring neural activity

Systems and Methods for Monitoring Neural Activity A method of monitoring neural activity responsive to a stimulus in a brain or a subject under general anaesthetic, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.

Methods of assessing and treating hepatic encephalopathy

The present disclosure relates to methods of treating or ameliorating hepatic encephalopathy (HE), including assessing the severity of HE in a patient suffering from HE, or the determining the presence or occurrence of an overt hepatic encephalopathy (OHE) event. In particular, some aspects of the methods use a novel Hepatic Encephalopathy Staging Tool (HEST), which includes a set of criteria to categorize the HE into different stages and provide guidance on effective treatments based on the severity of the HE. Other aspects of the methods use an Overt Hepatic Encephalopathy Screening Tool (O-HEST) to determine whether an OHE event is occurring or has occurred and provide guidance on proper medical attention and change in treatment.

System and method for detecting and monitoring blast exposure using magnetic resonance spectroscopy (MRS)

A system and method identifies blast exposure by the use of magnetic resonance spectroscopy (MRS) to measure absolute and relative concentrations of metabolites in specific brain regions in the central nervous system or brain. The system and method can be used as a diagnostic tool for the assessment of blast exposure. These chemical changes in the brain of those people suffering from blast exposure are different from those suffering from head injury, chronic pain and other neurological conditions.

Method for diagnosis and treatment of vessel occlusion

Systems, methods and devices for a skull/brain interface

Field-deployable concussion detector

Method and system for detecting white matter neural injury and predicting neurological outcome particularly for preterm infants

Systems and methods for brain activity interpretation

The present invention provides a computer-implemented method, including: obtaining an electrical signal data representative of brain activity of a particular individual; processing the electrical signal data based upon a pre-determined predictor associated with a particular brain state, selected from a library of predictors containing a plurality of pre-determined predictors, wherein the pre-determined predictor associated with a particular brain state includes: a pre-determined representative set of wavelet packet atoms, created from the pre-determined mother wavelet, a pre-determined ordering of wavelet packet atoms, and a pre-determined set of normalization factors, wherein the processing includes: causing the electrical signal data to be deconstructed into a plurality of pre-determined deconstructed wavelet packet atoms, utilizing the pre-determined representative set of wavelet packet atoms, wherein time windows of the electrical signal data are projected onto the pre-determined representative ...

Nose stimulator for producing a stimulation signal to a nose.

An electronic stimulation system has ?a casing (11); electronics (12) inside the casing (11) a first detector (16(1)) arranged to sense whether a human being is breathing or not, a stimulation device (17) arranged to receive a control signal from said electronics (12) and to provide stimuli to a nasal philtre or a human nasopharynx. The electronics (12) generate the control signal in dependence on the breathing signal and the system has a holding device for attaching the stimulation device to the nose.

Localized collection of biological signals, cursor control in speech-assistance interface based on biological electrical signals and arousal detection based on biological electrical signals

The present disclosure provides a device with electrodes configured to record electrical activity that are confined to a restricted area, using recorded biological electrical signals to control cursor position in a speech-assistance interface, and using recorded biological signals to detect arousals during sleep.

Nose stimulator for producing a stimulation signal to a nose.

Monitoring brain neural potentials

Neural activity in the brain arising from a stimulus is monitored. A stimulus is applied to a target structure of the brain and a neural measurement is obtained from at least one electrode implanted in contact with the target structure. The neural measurement is configured to capture a measure of any late response arising in the target structure, typically being a neural response arising after conclusion of an ECAP, such as in the period 1.5 – 10 ms after stimulus onset. The late response(s) can be a useful biomarker such as of therapeutic ranges of deep brain stimulation, disease progression, medication efficacy, and intra-operative changes.

Neurostimulator

A neurostimulator device for use with groups (e.g. more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each of the groups. The neurostimulator may also 5 include at least one processor configured to direct the stimulation assembly to deliver stimulation to the groups. The stimulation delivered to at least one of the groups may include one or more waveform shapes other than a square or rectangular wave shape. The processor may receive data from one or more sensors and use that data to modify the stimulation delivered. The neurostimulator may be configured to communicate with 10 an external computing device. The neurostimulator may send data to and/or receive data and/or instructions from the computing device. The computing device may use information collected by one or more sensors to at least partially determine stimulation parameters to communicate to the neurostimulator.

Localized collection of biological signals, cursor control in speech-assistance interface based on biological electrical signals and arousal detection based on biological electrical signals

The present disclosure provides a device with electrodes configured to record electrical activity that are confined to a restricted area, using recorded biological electrical signals to control cursor position in a speech-assistance interface, and using recorded biological signals to detect arousals during sleep.

Medical applications of orthogonal polarization spectral imaging

Microwave hemorrhagic stroke detector

COGNITIVE PLATFORM COUPLED WITH A PHYSIOLOGICAL COMPONENT

Example systems, methods, and apparatus, including cognitive platforms, are provided for computing performance metrics of an individual based at least in part on user interaction(s) with computerized tasks and/or interference and at least one physiological measure of the individual, where the performance metric provides an indication of the cognitive abilities of the individual. The apparatus can be coupled to at least one physiological component to perform the physiological measurement of the individual. The apparatus also can be configured to adapt the tasks and/or interferences to enhance the individual's cognitive abilities.

APPARATUS AND METHODS FOR PREDICTING THERAPY OUTCOME

Apparatus and methods are described for use with electrophysiological signal detecting electrodes (14), and a transcranial magnetic stimulation device (10). A computer processor (16) drives the transcranial stimulation device to apply one or more pulses of transcranial magnetic stimulation to a subject. Within a given time period of applying one of the one or more pulses of transcranial magnetic stimulation to the subject, the computer processor detects an electrophysiological signal of the subject, using the electrophysiological signal detecting electrodes (14). At least partially in response thereto, the computer processor predicts an outcome of treating the subject for a neuropsychiatric condition, using a given therapy, and generates an output on an output device (18) in response to the predicted outcome. Other applications are also described.

METHOD FOR ASSESSING BRAIN FUNCTION AND PORTABLE AUTOMATIC BRAIN FUNCTION ASSESSMENT APPARATUS

An apparatus for determining the neurological state of a subject, comprising: a set of electrodes configured to be placed on the subject to collect brain electrical signals; a processor; a memory operatively coupled to the processor, wherein the memory stores one or more operating instructions; and an input-output interface having at least one channel operatively coupled to the processor, wherein the input-output interface is configured to receive brain electrical signals through the set of electrodes; and the processor is configured to utilize the one or more operating instructions to perform one or more operations on the signals received through the input-output interface, wherein the one or more operations comprise: de-noising the received signals; extracting features from the de-noised signals; classifying the extracted features; and determining a neurological state of the subject based on the classification, wherein determining the neurological state comprises the steps of: determining ...

OBJECTIVE BALANCE ERROR SCORING SYSTEM

The present document describes a computer implemented system and method for performing a quantitative balance assessment on a subject. The method comprises instructing the subject to perform an assessment task with at least a first kinematic sensor mounted on the subject's head; collecting kinematic sensor measurements, comparing the measurements to a threshold value; summing the total number of kinematic sensor measurements that exceed the threshold value to generate a numerical score indicative of the subject's postural stability. The system makes use of only kinematic data collected from the wireless sensors to quantify BESS, and generate a BESS score, without any other physiological variables such as forward sway.

EYE MOVEMENT MONITORING OF BRAIN FUNCTION

The present disclosure provides a wearable device for the detection of mild traumatic brain injury, such as concussions, and methods of use thereof. Further disclosed are a method and system for detecting a mild traumatic brain injury.

COMPUTERIZED REPLACEMENT TEMPLE FOR STANDARD EYEWEAR

In various embodiments, a computerized eyewear retrofit kit comprises a replacement temple configured to replace a temple of a pair of eyewear. The replacement temple comprises an elongated body having a first end configured to attach the replacement temple to the eyewear, at least one of a first group of one or more sensors coupled to the elongated body or a second group of one or more sensors configured to couple to a frame of the standard pair of eyewear. The at least one of the first or second group of sensors are for sensing at least one of a physiological characteristic of the wearer or an environmental characteristic associated with the wearer. The eyewear retrofit kit also comprises at least one processor and a power source that are operatively coupled to at least one of the first group or the second group of the one or more sensors.

ELECTROENCEPHALOGRAPHY BASED SYSTEMS AND METHODS FOR SELECTING THERAPIES AND PREDICTING OUTCOMES

A method and system for utilizing neurophysiologic information obtained by techniques such as quantitative electroencephalography (QEEG), electrode recordings, MRI in appropriately matching patients with therapeutic entities is disclosed. The present invention enables utilization of neurophysiologic information, notwithstanding its weak correlation with extant diagnostic schemes for mental disorders, for safer and expeditious treatment for mental disorders, discovering new applications for therapeutic entities, improved testing of candidate therapeutic entities, inferring the presence or absence of a desirable response to a treatment, and deducing the mode of action of one or more therapeutic entities. In particular, methods for effectively comparing neurophysiologic information relative to a reference set are disclosed along with database-based tools for deducing therapeutic entity actions on particular patients such that these tools are readily accessible to remote users.

HANDHELD EMG STIMULATOR DEVICE WITH ADJUSTABLE SHAFT LENGTH

A nerve stimulating device with an adjustable length is shown and described. The device includes a handle and an elongated shaft with a stimulating electrode. The stimulating electrode can be selectively positioned to a plurality of distances relative to the handle. The device allows nerves in nerve regions at multiple positions relative to the surface of the patient's body to be stimulated with a single device.

BIOLOGICAL MARKERS AND RESPONSE TO TREATMENT FOR PAIN, INFLAMMATION, NEURONAL OR VASCULAR INJURY AND METHODS OF USE

METHOD AND SYSTEM FOR QUANTITATIVE EVALUATION OF VISUALLY - MOTOR RESPONSE

MRI surgical systems including MRI-compatible surgical cannulae for transferring a substance to and/or from a patient

A cannula for transferring a substance to and/or from a patient includes a tubular support sleeve and a transfer tube. The support sleeve includes a rigid tubular member defining a lumen extending from a proximal end to a distal end of the tubular member. The transfer tube is positioned in the lumen and extends beyond each of the proximal end and the distal end of the tubular member. The tubular member includes a rigid, MRI-compatible material.

METHOD AND SYSTEM FOR PROVIDING ELECTRICAL STIMULATION TO A USER

A method for providing electrical stimulation to a user, the method comprising: providing an electrical stimulation device, in communication with a controller, at a head region of the user; with the electrical stimulation device, providing a stimulation treatment having a waveform configured for neuromodulation in the user; with the controller, performing an adjustment to the stimulation treatment, wherein performing the adjustment includes: generating a transformed waveform with application of a transfer function to the waveform, wherein the transfer function scales the waveform and selectively attenuates extreme waveform values while maintaining a frequency characteristic of the waveform in the transformed waveform; and applying the transformed waveform with the electrical stimulation device, thereby modulating the stimulation treatment.

Partial aortic occlusion devices and methods for cerebral perfusion augmentation

Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.

Concussion indicator

A concussion indicator that may easily be applied to a helmet is provided. The concussion indicator may visually or audibly provide indicators relating to impacts creating accelerations of the helmet that likely cause a concussion. In some embodiments, three separate indicators may be used within a single base; each indicator is configured to indicate at impacts relating to different concussion grades. A rear of the base is attachable to a surface such as an interior or exterior of a helmet. Upon a concussion triggering acceleration, the concussion indicator will indicate that a concussion is likely. This display may be seen or heard by observers if the indicator is on an exterior of the helmet, and by the user or someone who removes the user's helmet if it is on the inside of the helmet.

SYSTEMS, DEVICES, AND METHODS FOR INTERPRETING MOVEMENT

According to some exemplary embodiments, a method or system can involve associating a plurality of biokinetographic comparison results with a first specific dysfunction from a group of specific dysfunctions, each of the biokinetographic comparison results obtained from a comparison of a biokinetographic value to a standard for a corresponding biokinetographic variable.

WHITE MATTER FIBROGRAPHY BY SYNTHETIC MAGNETIC RESONANCE IMAGING

Methods of making a white matter fibrogram representing the connectome of the brain of a subject, comprising: (a) performing a multispectral multislice magnetic resonance scan on the brain of a subject, (b) storing image data indicative of a plurality of magnetic resonance weightings of each of a plurality of slices of the brain of the subject to provide directly acquired images, (c) processing the directly acquired images to generate a plurality of quantitative maps of the brain indicative of a plurality of qMRI parameters of the subject, (d) constructing a plurality of magnetic resonance images indicative of white matter structure from the quantitative maps, and (e) rendering a white matter fibrogram of the brain of the subject from the plurality of magnetic resonance images.

FLEXIBLE BRAIN PROBE OVER GUIDEWIRE

In one embodiment, a brain probe system includes a guidewire configured to be inserted into blood vessels of a brain of a living subject, a flexible tube having a lumen sized to fit around the guidewire, the lumen being configured to slide axially over the guidewire so that a length of the lumen surrounds a length of the guidewire in the blood vessels of the brain, the flexible tube including a distal end, and at least one bipolar electrode pair disposed in the distal end of the flexible tube, and configured to detect signals indicative of respective electrical activity of the brain at respective locations in the blood vessels of the brain.

Systems and methods for selective auto-retroperfusion along with regional mild hypothermia

Systems and methods for selective auto-retroperfusion along with regional mild hypothermia. In at least one embodiment of a system for providing a retroperfusion therapy to a venous vessel of the present disclosure, the system comprises a catheter for controlling blood perfusion pressure, the catheter comprising a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, and at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen, and adapted to move between an expanded configuration and a deflated configuration, and a flow unit for regulating the flow and pressure of a bodily fluid, and a regional hypothermia system operably coupled to the catheter, the regional hypothermia system operable to reduce and/or regulate a ...

СПОСОБЫ ДИАГНОСТИКИ И ВЫЯВЛЕНИЯ ЭЛЕКТРИЧЕСКИХ МАРКЕРОВ СКРЫТЫХ ЗАБОЛЕВАНИЙ

... 1. Способ диагностирования невидимых (скрытых) заболеваний у пациентов-людей, который включает:(a) размещение по меньшей мере двух расположенных на некотором расстоянии электродов на коже пациента;(b) обнаружение и регистрацию биоэлектрического сигнала в зоне упомянутых электродов и вокруг них;(c) преобразование упомянутого биоэлектрического сигнала в график;(d) сравнение упомянутого полученного графика для пациента с по меньшей мере одним графиком базы для нормальных здоровых людей; и(e) определение наличия невидимого (скрытого) заболевания на основании упомянутого сравнения.2. Способ по п.1, отличающийся тем, что упомянутое размещение упомянутых электродов выполнено на поверхности ноги пациента.3. Способ по п.1, отличающийся тем, что упомянутое обнаружение и регистрация биоэлектрического сигнала осуществлены как обнаружение и регистрация биоэлектрического стохастического сигнала.4. Способ по п.3, отличающийся тем, что упомянутые обнаружение и регистрация биоэлектрического сигнала осуществлены ...

Evaluation by octave analysis

A method of examining a bodily function. A first set of frequency characteristics and amplitude characteristics of a first electrical signal deriving from rhythmic activity of a nerve in a living body is detected at a first condition. The nerve is stimulated to a second condition and a second set of frequency characteristics and amplitude characteristics of a second electrical signal deriving from the rhythmic activity of said nerve is detected. The fundamental frequency present in the frequency characteristics is identified. From the fundamental frequency the frequencies corresponding to a plurality of octaves of said fundamental frequency are calculated. The amplitude of said electrical signals at said octaves is identified. For said first signal a first amplitude ratio is calculated being the ratio of the amplitude difference between a first pair of said octaves, and the amplitude difference between a second pair of said octaves. For said second signal a second amplitude ratio is calculated ...

Improved method of determining metabolic function

Nerve stimulation and monitoring device

Nerve stimulation and monitoring device

A nerve interface device comprises at least one cuff portion 5, 7; and a first pair of electrodes, 15, 17 mounted on the cuff portion, wherein the cuff portion forms at least part of a passageway for receiving a nerve 13 along a cuff axis 19 passing through the passageway, and wherein the electrodes are spaced apart in the direction of the cuff axis 19. The device may be used in a nerve stimulation system, using a stimulation device to generate an electrical signal. The device may further form part of an implantable system for stimulating and/or monitoring activity of a nerve. The implantable system may be used in a method of modulating activity, or in a method of stimulating and monitoring activity of a nerve. A second pair of electrodes may be mounted on the cuff portion in a ring, concentric to the first pair of electrodes. A physiological sensor and comparison module may also be provided to detect physiological activity and the relationship between the electrical signals and physiological ...

System for processing images to detect properties of skeletal muscle

One or more properties of motor units of skeletal muscle are determined by analysing a time series of Magnetic Resonance, MR, images representing a slice of a body part to identify signal voids in one or more images of the series. A comparison of at least one characteristic of the identified signal voids in the images is performed with a control data set of MR images produced by applying a controlled stimulus to a motor nerve to establish inherent characteristics of signal voids corresponding to motor units of skeletal muscle. Properties of candidate motor units are analysed to confirm or reject them as motor units and at least one of: a firing frequency of at least one of the confirmed motor units, a size of at least one of the confirmed motor units, a number of confirmed motor units in a given image area or a shape of at least one of the confirmed motor units is determined.

Diagnostic method

PROCEDURE AND EQUIPMENT FOR THE PRODUCTION OF PENUMBRA AND INFARKTBILDER

BRAIN SYSTEM OF FUNCTIONS

PROCEDURE FOR THE FORECAST OF THE RESULTS OF TREATMENT

Systems and methods for assessing disorders affecting fine motor skills using handwriting recognition

Methods of diagnosis and of screening for electrical markers for hidden maladies

A method for diagnosing non- visible (occult) maladies in a human patient, the method comprising: (a) deploying at least two electrodes spaced apart on the skin of the patient; (b) detecting and recording a bioelectrical signal in and around said electrodes, the bioelectrical signal being a stochastic signal; (c) transforming the stochastic signal into a voltage versus frequency spectra using a Fast Fourier Transform (FFT) algorithm; (d) comparing a graph of a resultant FFT level of the patient to at least one graph of a baseline FFT level; and (e) determining a presents of a non- visible (occult) malady based on said comparison. Methods for monitoring a treatment regimen for non-visible (occult) maladies and for modulating the amplitude of endogenous bioelectrical stochastic signals in a human patient are also disclosed.

Instrumented mouthguard devices and components configured for use in instrumented mouthguard devices

Described herein is technology relating to instrumented mouthguard devices, for example, instrumented mouthguards which include components such as accelerometer modules which enable monitoring of head movements of a mouthguard wearer. Various embodiments that provide instrumented mouthguard devices and components configured for use in instrumented mouthguard devices, including flexible circuit board substrates. In some embodiments the flexible circuit board substrate is configured to allow sizing irregularities resultant from customisation of the mouthguard body to a specific wearer.

Neurostimulator

A neurostimulator device for use with groups (e.g., more than four groups) of electrodes. The neurostimulator may include a stimulation assembly configured to deliver different stimulation to each of the groups. The neurostimulator may also include at least one processor configured to direct the stimulation assembly to deliver stimulation to the groups. The stimulation delivered to at least one of the groups may include one or more waveform shapes other than a square or rectangular wave shape. The processor may receive data from one or more sensors and use that data to modify the stimulation delivered. The neurostimulator may be configured to communicate with an external computing device. The neurostimulator may send data to and/or receive data and/or instructions from the computing device. The computing device may use information collected by one or more sensors to at least partially determine stimulation parameters to communicate to the neurostimulator.

APPARATUS AND METHOD FOR ANALYZING PHYSIOLOGICAL CONDITIONS WITHIN AN ORGAN OF A LIVING BODY

METHODS OF ASSESSING AND TREATING HEPATIC ENCEPHALOPATHY

The present disclosure relates to methods of treating or ameliorating hepatic encephalopathy (HE), including assessing the severity of HE in a patient suffering from HE, or the determining the presence or occurrence of an overt hepatic encephalopathy (OHE) event. In particular, some aspects of the methods use a novel Hepatic Encephalopathy Staging Tool (HEST), which includes a set of criteria to categorize the HE into different stages and provide guidance on effective treatments based on the severity of the HE. Other aspects of the methods use an Overt Hepatic Encephalopathy Screening Tool (O-HEST) to determine whether an OHE event is occurring or has occurred and provide guidance on proper medical attention and change in treatment.

SYSTEM FOR ASSESSING A MENTAL HEALTH DISORDER

A system for assessing a mental health disorder in a human subject, the system comprising: a display configured to display a series of natural test images to the subject; an input by which the subject can input a response, following the display of each test image, as to whether or not the test image satisfies a predetermined categorisation criterion; a control processor configured to control the display of the test images by the display, to measure the duration of time from when each test image is initially displayed to when the corresponding response is input by the subject, and to generate a set of response data including the response times in respect of each of the test images; and a data processor configured to process the set of response data and to compare the processed response data with reference data to assess whether or not the subject has, or is likely to develop, the mental health disorder.

METHODS OF TREATING MITOCHONDRIAL DYSFUNCTION

This disclosure is directed to methods of treating or preventing mitochondrial dysfunction or mitochondrial disease in a subject comprising administration of probucol, or a pharmaceutically acceptable salt thereof. This disclosure is also directed to methods of diagnosing genetic mitochondrial disease in a subject prior to and in association with said treatment or prevention. This disclosure is also directed to methods of assessing and managing a subject with mitochondrial dysfunction or mitochondrial disease using a composite measurement.

PLATFORMS TO IMPLEMENT SIGNAL DETECTION METRICS IN ADAPTIVE RESPONSE-DEADLINE PROCEDURES

Example systems, methods, and apparatus, including cognitive platforms, are provided for applying signal detection metrics in computer-implemented adaptive response-deadline procedures to data collected based at least in part on user interaction(s) with computerized tasks and/or interferences. The apparatus can include a response classifier for generating a quantifier of the cognitive abilities of an individual. The apparatus also can be configured to adapt the tasks and/or interferences to enhance the individual's cognitive abilities.

METHOD AND APPARATUS FOR ASSESSING PROPRIOCEPTIVE FUNCTION

This invention relates to a method and apparatus for assessing propriocep tion in a subject. One embodiment of an apparatus of the invention comprises two articulating members attachable to a pair of limbs of a subject, and pr ovides data relating to geometry and/or location and/or motion of each limb in 2- or 3- dimensional space. The apparatus may include means for monitorin g gaze direction. The apparatus may comprise a robotic linkage. One embodime nt of the method comprises obtaining data relating to the geometry and/or lo cation and/or motion of the limbs, or portions thereof, of a subject as the subject performs a matching task. Another embodiment comprises obtaining dat a relating to the location of a limb of a subject, together with data relati ng to gaze direction as the subject looks toward the perceived location of l imb.

A SET OF BLOCKS AND METHODS OF PLAY AND DIAGNOSIS

A set of blocks, for playing a game comprises a plurality of blocks, each block having one characteristic selected from the first category and one characteristic selected from the second category. At least some of the characteristics in the first category are different from one another and at least some of the characteristics in the second category are different from one another. Categories can include a degree of abstraction and may include shape, size, colour, texture, weight and surface finish. The blocks can be provided with a game board and a die, for playing a game or-for diagnosis. The blocks can be used for play, and for diagnosis of children with autism or other individuals with other neurological disorders.

METHOD AND APPARATUS FOR ASSESSING OR DETECTING BRAIN INJURY AND NEUROLOGICAL DISORDERS

A method and apparatus is provided for diagnosing, assessing, or detecting brain injury and/or a neurological disorder of a subject. Objects are presented to the subject over a range of locations within the subject's workspace such that the subject can interact with at least some of the presented objects using either the right or left limb, or portion thereof, of a pair of limbs. Position data and/or motion data and/or kinetic data of the left and right limbs or portions thereof with respect to a presented object are obtained, and a data set is acquired for a plurality of presented objects. The acquired data set provides information about brain injury and/or a neurological disorder in the subject.

Method and system for acquiring brain characteristic parameters and system and method for generating thrombolytic indication

The invention discloses a method and a system for acquiring brain characteristic parameters and a method and a system for generating a thrombolytic indication, which provide referential intermediate data for early diagnosis and treatment of acute ischemic stroke and effective referential data for thrombolytic therapy in clinic. In the invention, diffusion weighted imaging is adopted to overcome the drawback that the prior clinical art adopts both the diffusion weighted imaging and perfusion weighted imaging, namely, a perfusion abnormal degree characterizing function of the perfusion weighted imaging is demonstrated without using the perfusion weighted imaging so as to provide the intermediate data that are capable of saving brain tissues and eliminating risks in the thrombolytic therapy, and the like. In the invention, a core region and a transitional region are accurately acquired by an adopted binary treatment which is based on ADC low signal restriction and DWI high signal restriction ...

Non-invasive intracranial monitor

A method of estimating at least one intracranial hemodynamic parameter in a subject, the method comprising: a) obtaining data of changes in electrical impedance across the subject's head as a function of time; b) analyzing the data; and c) estimating one or more of intracranial pressure, cerebral blood volume, and a factor related to at least one of cerebral perfusion pressure and a mean transit time through cerebral capillaries.

신경심리검사를 이용한 치매 발병 예측 방법 및 예측 시스템

... 신경심리검사를 이용한 치매 발병 예측 방법은 컴퓨터 장치가 피험자의 나이 및 피험자의 신경심리검사 데이터를 입력받은 단계, 상기 컴퓨터 장치가 상기 신경심리검사 데이터를 기준으로 경도인지장애 유형을 분류하는 단계, 상기 컴퓨터 장치가 상기 나이 및 상기 경도인지장애 유형을 노모그램을 이용한 치매 예측 모델에 입력하는 단계 및 상기 컴퓨터 장치가 상기 치매 예측 모델의 출력 결과에 따른 치매 예측 정보를 생성하는 단계를 포함한다.

METHOD OF DIAGNOSING AND STABILIZING CFS/ME SYMPTOMS IN A CANDIDATE PATIENT

METHOD AND APPARATUS FOR CONTROLLING A NEURAL STIMULUS - H

Anodic pulses are used to modify neural sensitivity to a stimulus. Propagation of a neural response from a stimulus site past a distal site can be blocked by applying an anodic pulse just prior to arrival of the travelling neural response at the distal site. The anodic pulse modifies the nerve membrane threshold and prevents one node of Ranvier from activating the next by hyperpolarising its membrane. The modified neural sensitivity can also be used to improve recruitment efficacy of the stimulus, by applying the anodic pulse prior to the stimulus to hyperpolarize the nerve fibre membranes, and then applying the stimulus at a time when the nerve fibre membranes have an inward current due to recovery from the hyperpolarization.

Method and apparatus for biometric analysis using EEG and EMG signals

Biometric assessment is performed by use of electromyography (EMG) signals detected from muscles at several locations on the hand/or other part of the body subject to fine motor control. In addition, electroencephalography (EEG), signals detect other biomarkers. The EMG and EEG signals are sensed, synchronized and registered. The signals are converted into digital data and are stored and processed for use in performing the biometric assessment.

Methods for measuring global glymphatic flow using magnetic resonance imaging

Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.

Power management of a system for measuring the acceleration of a body part

The present invention provides an apparatus and method for determining the magnitude of linear and rotational acceleration of an impact to a body part. The apparatus can be used with protective sports equipment, such as a sports helmet, wherein the apparatus includes a battery, a number of accelerometers positioned proximate to the outer surface of the head, and an electronic device with a processor and a transmitter to transmit data received from the accelerometers. To maximize the battery life and minimize power consumption by the electronic device, the apparatus includes a power management system with a sensor assembly. The sensor assembly sends a first signal to the electronic device to initiate operation when the sensor assembly detects the presence of an object within the helmet, and a second signal to the electronic device to cease operation when the sensor assembly detects the absence of the object. The sensor assembly may be a proximity sensor, more specifically an inductive, capacitive ...

METHODS AND SYSTEMS FOR DIAGNOSIS AND TREATMENT OF NEURAL DISEASES AND DISORDERS

The invention disclosed herein relates to methods and systems for modulating activity of a nervous system component. Neural pattern recognition is used to identify a neurological and/or psychiatric disease or disorder based on input generated by electric signals indicative of the subject's brain activity. In an embodiment, the method comprises receiving an input from one or more sensors, each sensor configured to sense a particular characteristic indicative of a neurological or psychiatric condition or state; developing treatment parameters based on the input received from the one or more sensors; and generating neural modulation signals for delivery to a nervous system component through one or more output devices in accordance with one or more developed treatment parameters.

Non-Invasive Intracranial Monitor

A method of estimating at least one intracranial hemodynamic parameter in a subject, the method comprising: a) obtaining data of changes in electrical impedance across the subject's head as a function of time; b) analyzing the data; and c) estimating one or more of intracranial pressure, cerebral blood volume, and a factor related to at least one of cerebral perfusion pressure and a mean transit time through cerebral capillaries.

Partial aortic occlusion devices and methods for cerebral perfusion augmentation

Methods are provided for partial aortic occlusion for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially occlude aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. The methods can also be used to partially occlude the renal arteries to reduce renin secretion in hypertensive patients. Partial occlusion of a vessel can be accomplished by a device comprising an elongate catheter, a distally mounted expandable occluder, a variable flow mechanism, and a manometer. The occluder may comprise two conical shells or an inflatable ring-shaped balloon disposed about a cylindrical sleeve. Other medical devices, such as an atherectomy catheter, can be inserted distal the occluder to provide therapeutic intervention.

Portable device for providing non-contact heat-evoked potentials

Provided herein is a device, a system, and a method of using the device and system to deliver non-contact thermal stimulation to the skin of a person and, by detecting evoked potentials in that person's central nervous system, to determine a neurological condition of the person.

Systems, methods and devices for a skull/brain interface

Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.

СИСТЕМА И СПОСОБ ДЛЯ ДИАГНОСТИКИ НАРУШЕНИЙ ДЕЯТЕЛЬНОСТИ СТВОЛА ГОЛОВНОГО МОЗГА

Изобретение относится к медицине, а именно к средствам для диагностики нарушений деятельности ствола головного мозга, посредством аудиометрии ствола головного мозга. Система содержит устройство для формирования звуковых раздражителей, элемент связи, передающий звуковые раздражители, через устройство формирования звука, субъекту, устройство для анализа и хранения информации, относящейся к электрофизиологической активности головного мозга. Звуковые раздражители изменяются по частоте, времени и амплитуде. Устройство для формирования раздражителей присоединено к устройству запуска и передает сигнал запуска, через устройство запуска в устройство для анализа и хранения электрофизиологической активности головного мозга, одновременно с передачей звуковых раздражителей на субъект. Использование изобретения повышает достоверность при диагностике нарушений деятельности ствола головного мозга. 13 з.п. ф-лы, 5 ил.

СПОСОБ ДИАГНОСТИКИ РЕТРОКОХЛЕАРНЫХ И ЦЕНТРАЛЬНЫХ СЛУХОВЫХ НАРУШЕНИЙ

Изобретение относится к области медицины, а именно к отоневрологии. При наличии у больного жалоб на шум в ухе без снижения или со снижением слуха больному проводят тональную пороговую аудиометрию (ТПА) и тимпанометрию. Дополнительно исследуют коротколатентные слуховые вызванные потенциалы (КСВП) и акустический рефлекс. Тональную пороговую аудиометрию проводят в расширенном диапазоне частот от 125 до 20000 герц. Если при исследовании выявляется нейросенсорная тугоухость различной степени выраженности, диссоциация или выпадение ипси- или контралатеральных рефлексов, при исследовании КСВП наблюдается уменьшение амплитуды 3-5 пиков и удлинение латентных периодов между ними по сравнению с нормой, а при исследовании ТПА отмечаются такие особенности поражения слуха, как повышение порогов чувствительности в диапазоне 16000-20000 герц, то диагностируют поражение слухового анализатора, обусловленное демиелинизацией в центральной нервной системе, что позволяет выявить рассеянный склероз на ранней ...

Способ и устройство для обнаружения начала гипогликемии

... 1. Способ предупреждения пользователя о начале гипогликемии, включающий следующие шаги:i) прием сигнала физиологического тремора от портативного датчика, носимого пользователем;ii) анализ сигнала физиологического тремора в течение первого периода времени для определения мощности упомянутого сигнала тремора иiii) формирование предупреждения только на основе обнаружения изменения сигнала физиологического тремора, указывающего на начало гипогликемии у пользователя,при этом начало гипогликемии соответствует падению уровня глюкозы в крови (BGL) ниже 5 ммоль/л, и обнаруженное изменение сигнала физиологического тремора представляет собой увеличение мощности сигнала тремора по меньшей мере на 50% относительно опорного значения.2. Способ по п. 1, в котором упомянутый портативный датчик включает акселерометр.3. Способ по п. 1 или 2, в котором упомянутое опорное значение представляет собой заранее заданный базовый уровень.4. Способ по п. 3, в котором упомянутый заранее заданный базовый уровень заранее ...

Determination of temperature over carotid arteries for risk determination of brain embolism for preventing apoplectic stroke, by telemetrically measuring temperature of left and right carotid arteries and their surrounding regions

Method for determining temperature over carotid arteries, involves telemetrically measuring temperature of right and left carotid arteries and their surrounding regions. An independent claim is included for device for determining the temperature of the carotid arteries.

Evaluation by octave analysis

DEVICE FOR THE CLASSIFICATION OF FABRIC

USE OF A COLORING MATERIAL FOR THE PRODUCTION OF AN AGENT FOR THE IMAGE REPRESENTATION OF COMPACT TUMORS AND COMBINATION OF A COLORING MATERIAL WITH AN APPARATUS FOR THE IMAGE REPRESENTATION OF COMPACT TUMORS, THE KORTEX AND THE NERVE COURSES

Method of predicting functional outcome of a stroke using eeg measures

Field-deployable concussion detector

Non-human animal models of depression and methods of use thereof

The disclosure provides non-human optogenetic animal models of depression. Specifically, non-human animals each expresses a light- responsive opsin in a neuron of the animal are provided. The animal models are useful for identifying agents and targets of therapeutic strategies for treatment of depression. Examples of using the non-human animals expressing light-responsive opsin including Halorhodopsin family of light-responsive chloride pumps and Channelrhodopsin family of light-responsive cation channel proteins are described.

System and method for assessing impulse control disorder

A method of assessing the likelihood that an individual has impulse control disorder. The individual is provided with an actuator, and instructed to actuate the actuator as an acknowledgement of when the individual has completed a reward task. Actuation of the actuator is monitored and recorded. An automated diagnosis of ICD is produced and output, wherein a greater degree of actuation of the actuator by the individual is taken to indicate a greater likelihood that the individual has impulse control disorder.

The present invention relates to neurostimulation, and in particular relates to methods and devices for optimising or revising neurostimulation paradigms in response to changes in medication dosages or changed medication responses.

Abstract A system for delivering electrical neurostimulation therapy concurrently with a medicament regime involving changing or titrating electrical neurostimulation in response to changed medication. The system comprising: a neuromodulation device to deliver the electrical neurostimulation therapy, measurement circuitry configured to capture recordings of neural responses evoked by the electrical neurostimulation therapy, a processor configured to process the recordings of the neural responses in order to obtain a plurality of measures of neural activation in response to a plurality of stimuli delivered over time, the processor further configured to revise the stimulus parameter in order to maintain neural activation within a target therapeutic window, the processor further configured to adjust bounds of the target therapeutic window in response to an indicia of a change in the medicament regime. Fig. 1 110 ELECTRODE SELECTION 126 POWER PULSE AMPLIFIER & I 150 SOURCE GENERATOR ADC 112 ...

Sensing or stimulating activity of tissue

An intravascular device for placement within an animal vessel, the intravascular device being adapted to at least one of sense and stimulate activity of neural tissue located outside the vessel proximate the intravascular device.

Method and device for deep brain stimulation

METHOD AND DEVICE FOR DEEP BRAIN STIMULATION 5 A method of treatment performed on a subject's brain, the method including a step of applying one or more neuromodulation signals to the lateral habenula and the posterior commissure. [FIG. 1] co xx C - 6) Co C - ...

Sensor assembly for monitoring an infant brain

System and method for generating electromagnetic treatment protocols

A system includes a communication interface for receiving information that includes data collected from an array of neural activity sensors that were placed on a patient during a session of applied stimuli. A processor is configured to analyze the received information to obtain a frequency spectrum for each sensor for a given stimulus of the applied stimuli. Neural network frequencies that correspond to an indicated impaired functionality of the nervous system of the patient are selected. For each selected frequencies, a spatial map of neural activity is generated. Each of the generated spatial maps is compared with retrieved corresponding spatial maps to identify treatment frequencies from among the selected neural network frequencies. A treatment protocol is generated for input into an electromagnetic field generator to cause the generator to apply to the patient an electromagnetic field at each identified treatment frequency.

Systems and methods for brain activity interpretation

The present invention provides a computer-implemented method, including: obtaining an electrical signal data representative of brain activity of a particular individual; processing the electrical signal data based upon a pre-determined predictor associated with a particular brain state, selected from a library of predictors containing a plurality of pre-determined predictors, wherein the pre-determined predictor associated with a particular brain state includes: a pre-determined representative set of wavelet packet atoms, created from the pre-determined mother wavelet, a pre-determined ordering of wavelet packet atoms, and a pre-determined set of normalization factors, wherein the processing includes: causing the electrical signal data to be deconstructed into a plurality of pre-determined deconstructed wavelet packet atoms, utilizing the pre-determined representative set of wavelet packet atoms, wherein time windows of the electrical signal data are projected onto the pre-determined representative ...

SYSTEMS AND METHODS FOR BRAIN ACTIVITY INTERPRETATION

Abstract The present invention provides a computer-implemented method, including: a. obtaining, in real-time, by a specifically programmed processor, electrical signal data representative of brain activity of a particular individual; b. processing, in real-time the electrical signal data representative of brain activity of a particular individual based upon a pre-determined predictor associated with a particular brain state, selected from a library of predictors containing a plurality of pre-determined predictors, wherein each individual pre-determined predictor is associated with a unique brain state, wherein the pre-determined predictor associated with a particular brain state includes: i. a pre-determined mother wavelet, ii. a pre-determined representative set of wavelet packet atoms, created from the pre-determined mother wavelet, iii. a pre-determined ordering of wavelet packet atoms, and iv. a pre-determined set of normalization factors, wherein the processing includes: i. causing ...

A SYSTEM AND METHOD FOR DETECTING NEUROMUSCULAR DISORDERS USING EMG SIGNALS BASED ON TQWT FEATURES

The present disclosure relates to a system and a method for detecting neuromuscular disorders using EMG signals based on TQWT features. The method facilitates a proficient technique that supports wavelet alter using tunable Q-factor wavelet transform (TQWT) is proposed in favor to identify disorder related to neuromuscular domain of EMG signals. The EMG signal is decomposed by TQWT technique into sub-bands and these sub-bands are used intended for decisive spectral options, significantly spectral uniformity, considerably spectral stretch, spectral decline and applied mathematics option resembling kurtosis, mean utter deviation, along with interquartile assortment. The inputs to extreme learning machine classifier are the extracted features in array to identify and analyze EMG signals associated toward neuromuscular disorder. Along with implications attained from this technique illustrates a much superior classification dedicated to neuromuscular commotion of electromyogram signals when ...

SYSTEMS AND METHODS FOR DETECTING NEUROLOGICAL CONDITIONS

Systems, apparatuses, methods, and non-transitory computer-readable media related to a tool for determining presence or absence of a neurological condition in a subject are provided. The tool includes an ultrasound device configured to collect ultrasound data from a head of the subject. The tool further includes a processing circuit configured to calculate a curvature metric based on the ultrasound data. The processing circuit is further configured to calculate a velocity asymmetry metric based on the ultrasound data. The tool is further configured to determine presence or absence of the neurological condition in the subject based on the curvature metric and the velocity asymmetry metric.

INSTRUMENTED MOUTHGUARD DEVICES AND COMPONENTS CONFIGURED FOR USE IN INSTRUMENTED MOUTHGUARD DEVICES

Described herein is technology relating to instrumented mouthguard devices, for example, instrumented mouthguards which include components such as accelerometer modules which enable monitoring of head movements of a mouthguard wearer. Various embodiments that provide instrumented mouthguard devices and components configured for use in instrumented mouthguard devices, including flexible circuit board substrates. In some embodiments the flexible circuit board substrate is configured to allow sizing irregularities resultant from customisation of the mouthguard body to a specific wearer.

BRAIN MONITORING SYSTEM

Systems and methods capture light reflected back from a patient's fundus and compares the resulting images to prior images, to determine if the patient is experiencing intraocular inflammation or atrophy.

SYSTEMS AND METHODS FOR BRAIN ACTIVITY INTERPRETATION

The present invention provides a computer-implemented method, including: obtaining an electrical signal data representative of brain activity of a particular individual; processing the electrical signal data based upon a pre-determined predictor associated with a particular brain state, selected from a library of predictors containing a plurality of pre-determined predictors, wherein the pre-determined predictor associated with a particular brain state includes: a pre-determined representative set of wavelet packet atoms, created from the pre-determined mother wavelet, a pre-determined ordering of wavelet packet atoms, and a pre-determined set of normalization factors, wherein the processing includes: causing the electrical signal data to be deconstructed into a plurality of pre-determined deconstructed wavelet packet atoms, utilizing the pre-determined representative set of wavelet packet atoms, wherein time windows of the electrical signal data are projected onto the pre-determined representative ...

Method and apparatus for corrective secondary saccades analysis with video oculography system

A video oculography system for calculation and display of Corrective Secondary Saccades Analysis is disclosed. A method for Objective Diagnostics of at least one of traumatic brain injury, Internuclear Opthalmopligia, Ocular Lateral Pulsion, Progressive Supernuclear Palsy And Glissades comprises the steps of using a VOG system to calculate corrective saccades. The video oculography based system for the subject is configured to collect eye images of the patient in excess of 60 hz and configured to resolve eye movements smaller than at least 3 degrees of motion. The video oculography based system collects eye movement data wherein at least one fixation target is presented to the subject in a defined position configured to yield a voluntary saccadic eye response from at least one eye of the patient. The latency, amplitude, accuracy and velocity of each respective corrective saccade and totals latency and accuracy is calculated.

Spectral decomposition and display of three-dimensional electrical activity in the cerebral cortex

Systems and methods are provided for measuring electrical activity within a brain of a patient. An electrode array is configured to take measurements of electrical potential as raw electroencephalographic (EEG) data. A data processing component includes a spectral decomposition component configured to divide the raw EEG data into a plurality of frequency intervals, within a total range of frequencies and an inverse solution component configured to transform the raw EEG data associated with each frequency interval into a spatial mapping of electrical activity as to provide a set of parameters, with each parameter representing an average electrical activity at an associated location within the brain over an epoch of interest.

Set of blocks and methods of play and diagnosis

A set of blocks, for playing a game comprises a plurality of blocks, each block having one characteristic selected from the first category and one characteristic selected from the second category. At least some of the characteristics in the first category are different from one another and at least some of the characteristics in the second category are different from one another. Categories can include a degree of abstraction and may include shape, size, colour, texture, weight and surface finish. The blocks can be provided with a game board and a die, for playing a game or for diagnosis. The blocks can be used for play, and for diagnosis of children with autism or other individuals with other neurological disorders.

Health monitoring appliance

A heart monitoring system for a patient includes one or more wireless nodes forming a wireless network; a wearable appliance having a wireless transceiver to communicate with the one or more wireless nodes; and an analyzer to determine vital signs, the analyzer coupled to the wireless transceiver to receive patient data over the wireless network.

Hyperspectral imaging systems and related methods

Systems and methods for analyzing sublingual microcirculation perfusion and identifying particular nerve tracts. In exemplary embodiments, a digital micro-mirror device is configured to direct a reflected light to a subject area and a controller is configured to alter a parameter of the reflected light.

Cystic fibrosis diagnostic device and method

A method for detecting cystic fibrosis is disclosed, which is performed in a system comprising an anode and a cathode placed on different regions of the patient body, and an adjustable DC source, which is controlled in order to feed the anode with a DC current. The method includes applying DC voltage pulses of varying voltage values to the anode for given durations allowing the stabilization of electrochemical phenomena in the body in the vicinity of the electrodes, collecting data representative of the current between the electrodes, and of the potentials of the electrodes, for the different DC voltages, and from the data, computing data representative of the electrochemical skin conductance of the patient, and reconciling the latter data with reference data obtained in the same conditions on patients suffering or not from cystic fibrosis, and identifying the patient as suffering or not from cystic fibrosis.

Encephalography method and apparatus incorporating independent component analysis and a spectral shaping filter

Methods and apparatus for encephalography process encephalography data to yield components that correspond to modular areas of the brain. In some embodiments encephalography data is processed by independent component analysis to yield a first set of components that are processed to generate a spectral filter. The spectral filter is applied to the encephalography data to generate a second set of components. The second set of components may be represented by one or more matrices. In an embodiment the second set of components is represented by weight and sphereing matrices. Methods and apparatus may be applied for monitoring brain function, selecting participants for medical trials, adjusting drug dosages, performing and monitoring biofeedback methods, detecting progression toward diseases or conditions that affect the brain and other applications.

Method and System for Differential Diagnosis of Chronic Schizophrenia and Chronic Alcoholism

Biomarker diagnosis of chronic schizophrenia in the presence of cognitive impairment is confirmed when Phosphocreatine (PCr) levels are increased, compared to normal levels, in both the left and right prefrontal cortices of the brain, with increased PCr specifically also in the left basal ganglia and also reduced NA/Crin the left superior temporal region of the brain. Biomarker differential diagnosis is also taught for chronic alcoholism (with or without cognitive impairment) and for chronic schizophrenia even when cognitive impairment is absent. 1. A method for the differential diagnosis of chronic schizophrenia or chronic alcoholism , comprising imaging the brain of a subject in need of diagnosis for the markers PCr , NA/Cr , and sPDE and determining any increase or decrease in the presence of said markers compared to normal levels in specified anatomic areas of the brain , and outputting the results of the imaging as one or more files or images to be viewed by a user.2. The method according to claim 1 , wherein after quantifying PCr claim 1 , NA/Crand sPDE claim 1 , a determination that (1) PCr levels are increased claim 1 , compared to normal levels claim 1 , in both the left and right prefrontal cortices of the brain claim 1 , together with increased (2) PCr specifically also in the left basal ganglia and also (3) reduced NA/Crin the left superior temporal region of the brain claim 1 , together confirm a differential diagnosis of chronic schizophrenia when cognitive impairment is present.3. The method according to claim 1 , wherein after quantifying PCr claim 1 , NA/Crand sPDE claim 1 , a determination that (1) phosphocreatine (PCr) levels are increased in the right basal ganglia claim 1 , with (2) reduced NA/Crin all three of: (a) the left basal ganglia; (b) the right occipital cortex; and (c) the left centrum semiovale claim 1 , together with (3) reduced sPDE in the right inferior parietal and the right centrum semiovale claim 1 , together confirm a ...

Method and System for Diagnosis of Attention Deficit Hyperactivity Disorder from Magnetic Resonance Images

A method and system for automated diagnosis of attention deficit hyperactivity disorder (ADHD) from magnetic resonance images is disclosed. Anatomical features are extracted from a structural magnetic resonance image (MRI) of a patient. Functional features are extracted from a resting-state functional MRI (rsFMRI) series of the patient. An ADHD diagnosis for the patient is determined based on the anatomical features, the functional features, and phenotypic features of the patient using a trained classifier. An ADHD subtype may then be determined for patients diagnosed as ADHD positive using a second trained classifier. 1. A method for automated diagnosis of attention deficit hyperactivity disorder (ADHD) , comprising:extracting anatomical features from a structural magnetic resonance image (MRI) of a patient;extracting functional features from a resting-state functional MRI (rsFMRI) series of the patient; anddetermining an ADHD diagnosis for the patient based on the anatomical features, the functional features, and phenotypic features of the patient using a trained classifier.2. The method of claim 1 , wherein the structural MRI is a T-1 weighted MRI.3. The method of claim 1 , wherein the functional MRI series is a T2-weighted MRI series.4. The method of claim 1 , where the phenotypic features of the patient include age and gender of the patient.5. The method of claim 4 , wherein the phenotypic features of the patient further include handedness claim 4 , verbal IQ claim 4 , and performance IQ of the patient.6. The method of claim 1 , wherein extracting anatomical features from a structural magnetic resonance image (MRI) of a patient comprises:segmenting cortical hemisphere surfaces in the structural MRI; andextracting at least one anatomical feature at each of a plurality of uniformly spaced vertices on each of the cortical hemisphere surfaces.7. The method of claim 6 , wherein extracting at least one anatomical feature at each of a plurality of uniformly spaced ...

Fitness monitoring

A heart monitoring system for a user includes a body wearable appliance placed on or near the user skin and having one or more sensors to capture fitness data and a wireless transceiver to communicate fitness data; and a processor coupled to the wireless transceiver to receive fitness data.

Brain-Related Chronic Pain Disorder Treatment Method and Apparatus

A method for treating brain-related chronic pain disorders in human subjects includes assessing the brain function of a subject suffering from chronic pain, diagnosing a chronic pain-related abnormal brain condition, and mitigating the abnormal brain activity by applying an electrical stimulation signal to tissues corresponding to at least one area of abnormal brain activity.

HYPERSPECTRAL IMAGING SYSTEMS AND RELATED METHODS

Systems and methods for analyzing sublingual microcirculation perfusion and identifying particular nerve tracts. In exemplary embodiments, a digital micro-mirror device is configured to direct a reflected light to a subject area and a controller is configured to alter a parameter of the reflected light. 1. A system for identifying a nerve tract , the system comprising:a light source;a digital micro-mirror device;an optical detector;an analyzer;a controller coupled to the digital micro-mirror device; and the light source is configured to emit light to the digital micro-mirror device;', 'the digital micro-mirror device is configured to direct a reflected light to a subject area;', 'the controller is configured to alter a parameter of the reflected light;', 'the optical detector is configured to detect a response light from the subject area; and', 'the analyzer is configured to analyze the response light and generate an image of the subject area wherein the nerve tract is distinguished from an area surrounding the nerve tract., 'a stimulator configured to provide a stimulus to a nerve tract, wherein2. The system of wherein the analyzer is configured to generate an image of the subject area wherein the nerve tract is a different color than the area surrounding the nerve tract.3. The system of wherein the stimulator is configured as a flashing light.4. The system of wherein the stimulator is a component of eyewear configured to be worn by a subject.5. The system of wherein the controller is configured to alter the parameter of the reflected light at least once per second.6. The system of wherein the controller is configured to alter the parameter of the reflected light at least twice per second.7. The system of wherein the controller is configured to alter the parameter of the reflected light at least three times per second.8. The system of wherein the analyzer comprises a computer-readable medium configured to analyze the response light and generate an image of the ...

INSERTION OF MEDICAL DEVICES THROUGH NON-ORTHOGONAL AND ORTHOGONAL TRAJECTORIES WITHIN THE CRANIUM AND METHODS OF USING

The invention comprises an elongated device adapted for insertion, including self-insertion, through the body, especially the skull. The device has at least one effector or sensor and is configured to permit implantation of multiple functional components through a single entry site into the skull by directing the components at different angles. The device may be used to provide electrical, magnetic, and other stimulation therapy to a patient's brain. The lengths of the effectors, sensors, and other components may completely traverse skull thickness (at a diagonal angle) to barely protrude through to the brain's cortex. The components may directly contact the brain's cortex, but from there their signals can be directed to targets deeper within the brain. Effector lengths are directly proportional to their battery size and ability to store charge. Therefore, longer angled electrode effectors not limited by skull thickness permit longer-lasting batteries which expand treatment options. 1. (canceled)2. A device that creates an effect on a target site or that gathers data about a target site in a patient's body , comprising:a first shaft configured to be inserted through skin, muscle, tissue, bone, or skull; andat least one component, including an effector and/or sensor, housed within, passing through, or attached to the first shaft;wherein the shaft is configured to be self-inserting through an entry site in an absence of a premade hole, said first shaft having a diameter of less than 1 cm.3. The device of claim 2 , wherein the first shaft is configured to be self-inserting claim 2 , at the entry site claim 2 , orthogonally to a tangent of a surface at the entry site.4. The device of claim 2 , wherein the first shaft is configured to be self-inserting claim 2 , at the entry site claim 2 , at an angle between parallel and perpendicular to a tangent of a surface at the entry site.5. A system of devices according to claim 2 , wherein two or more devices are configured to ...

Medical therapy target definition

In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.

Method and apparatus for reducing the risk of neonatal neurological injury

A method for reducing the risk of neurological injury to a neonatal human child includes the steps of: (I) monitoring in a pregnant patient during labor at least a first set of parameters indicative of a present level of risk for neurological injury to the child as a fetus; (II) during the period between a cervical dilatation of 10 cm in the patient and delivery of the child and/or during at least the first 5 minutes following delivery of the child, determining a present level of risk for neurological injury to the child based on the at least first set of parameters at a given point in time during labor that is between a cervical dilatation of 10 cm in the patient and delivery of the child, and wherein the determined present level of risk corresponds to one of a plurality of predetermined levels of predicted risk for neurological injury to the child as a neonate; and (III) commencing monitoring the child for one or more postnatal parameters indicative of neurological injury or its onset within the first 5 minutes following delivery of the child, and/or performing one or more measures for treating the child for neurological injury or its onset within the first 60 minutes following delivery of the child.

METHOD OF MEASURING EFFICACY OF TREATMENT FOR AN AUTOIMMUNE DISEASE IN VIVARIUM ANIMALS

A method of measuring efficacy of test treatment of an autoimmune disease in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals, a standard of care or a reference treatment for the first disease to determine efficacy of the test treatment. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Other embodiment uses a Fourier transform on a circle, LASSO, RANSAC or regression analyses for curve fitting. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals. 1. A method of measuring efficacy of a first treatment of an autoimmune disease in a study animal in a vivarium comprising the steps of:(a) placing the study animal in a cage free of electronic penetrations in the vivarium and enrolling the study animal in a study;(b) electronically observing one or more animal activities in real-time of the study animal using a combination of electronic cameras, infrared (IR) lighting of the study animals, and electronic hardware including computation and communication hardware;(c) selecting a single “activity-drop metric” from the set: {regression analysis, LASSO, RANSAC, Monte Carlo} with an associated scalar “activity-drop value”;(d) collecting a set of “nightly activity data” comprising values of the associated scalar activity drop value from electronically observing the study animal repeatedly and continually for a night;(e) identifying automatically three consecutive time regions in the nightly activity data: a “high-activity region,” an “ ...

Method for evaluating multi-modal emotion cognition capability of patient with autism spectrum disorder

A method for evaluating a multi-modal emotion cognition capability of a patient with an autism spectrum disorder, mainly includes the following steps: (1) setting a multi-modal evaluation environment, where the multi-modal evaluation environment is used to stimulate a tested object; and the multi-modal evaluation environment includes: a visual scene, a verbal communication scene, and an emotional communication scene; (2) collecting multi-modal evaluation information, where the evaluation information includes: intelligence information, behavioral data, and eye movement data of the tested object; and (3) performing statistical analysis, to obtain an emotion cognition capability of the tested object, where the performing statistical analysis includes: performing statistical analysis on the behavioral data, performing statistical analysis on the eye movement data, and performing statistical analysis on a combination of the behavioral data and the eye movement data.

ENHANCED NEUROPSYCHOLOGICAL ASSESSMENT WITH EYE TRACKING

Provided are methods and system for assessing a human subject's neurological and/or psychological status. The methods entail displaying visual tests to a human subject, wherein each of the visual tests includes a visual target signal, optionally with visual cue signals, for eliciting visual and, optionally, body part, movements by the subject. Following the display, the movements are then detected. The latency and/or correctness of such movements can then be used to assess the subject's neurological and/or psychological status. Also provided are methods and systems for assessing performance validity. 138.-. (canceled)39. A system comprising a processor and program code which , when executed by the processor , configures the system to conduct an assessment of the neurological and/or psychological status of a subject comprising:displaying a plurality of visual tests to a human subject, wherein each visual test comprises a visual target signal associated with a commanded eye movement and, optionally, a commanded body part movement;detecting, following the display of each visual target signal, a responsive eye movement of the subject and, optionally, a responsive body part movement of the subject; andassessing the neurological and/or psychological status of the subject based on one or more of the latency and correctness of the responsive movements with regard to the commanded movements associated with each visual test.40. The system of claim 39 , wherein the correctness of a responsive movement is determined with reference to its correlation with the visual target signal of the visual test.41. The system of claim 39 , wherein one or more of the visual tests further comprises a visual cue signal displayed prior to the visual target signal.42. The system of claim 41 , wherein the visual cue signal is selected from the group consisting of nondirectional cue signals claim 41 , directional cue signals claim 41 , misdirectional cue signals claim 41 , inhibition cue signals ...

AUTOMATED ANALYSIS SYSTEM FOR THE DETECTION AND SCREENING OF NEUROLOGICAL DISORDERS AND DEFECTS

Objects of interest which project beyond the fovea are poorly resolved and lack color information, requiring movement of the eyes in order to obtain a comprehensive image and perception of the surrounding world. Eye movements emanate from different areas of the brain which can be affected by disease and or injury. As such, different neurological disorders will affect a myriad of eye movements in a variety of different ways. An automated system and method, capable of detecting, analyzing and summarizing a person's eye movements is used to detect (diagnose) (either before or after symptoms of said neurological disease are apparent), confirm a prior diagnosis, and/or to monitor the treatment effectiveness for a variety of neurological diseases, neurological movement disorders and potential brain injuries. The analyzed and summarized eye movements are cataloged, interpreted and utilized in a diagnostic matrix in order to highlight and distinguish abnormal eye movements, and to provide an objective clinical or pre-clinical/pre-symptomatic diagnosis based on the non-invasive testing procedures. 1. A computer implemented method for diagnosing or confirming a diagnosis of one or more neurological diseases , disorders , or injuries , or for monitoring a treatment regimen of said one or more neurological diseases , disorders , or injuries , comprising the steps of:detecting horizontal and vertical positions of one or both eyes of a subject in response to fixed and moving light stimulus using an eye tracking device;determining from data detected in said detecting step using one or more computers or computer networks, one or more values for saccadic measurements and one or more values of either or both fixation measurements or measurements associated with interruptions; said one or more values for saccadic measurements with stored values or value ranges for subjects which suffer from said one or more neurological diseases, disorders, or injuries, and', 'said one or more values ...

MAGNETOENCEPHALOGRAPHY BIOMARKERS OF GABA-B AGONIST DRUG ACTIVITY IN AUTISM SPECTRUM DISORDERS

Compositions and methods for diagnosing neurological disorders such as autism spectrum disorders are disclosed. 1. A method of diagnosing an autism spectrum disorder in a subject , said method comprising measuring brain activity in said subject by magnetoencephalography after administering an audio stimulus to the subject ,wherein a delay in the 50 and/or 100 ms response in said subject compared to a normal subject indicates that the subject has said autism spectrum disorder.2. A method of diagnosing an autism spectrum disorder in a subject , said method comprising measuring brain activity in said subject by magnetoencephalography after administering an audio stimulus to the subject ,wherein a decrease in the stimulus elicited activity in the gamma frequency band in said subject compared to a normal subject indicates that the subject has said autism spectrum disorder.3. The method of claim 1 , wherein the normal subject is age-matched with the subject.4. A method for screening for a therapy against an autism spectrum disorder claim 1 , said method comprising:a) administering a therapy to a subject; andb) measuring brain activity in said subject by magnetoencephalography after administering an audio stimulus to the subject,wherein a decrease in the delay in the 50 and/or 100 ms response in said subject compared to baseline indicates that the therapy is effective against said autism spectrum disorder, orwherein an increase in the stimulus elicited activity in the gamma frequency band in said subject compared to baseline indicates that the therapy is effective against said autism spectrum disorder.5. The method of claim 4 , further comprising determining the baseline of the subject by measuring brain activity in said subject by magnetoencephalography after administering an audio stimulus to the subject prior to the administration of the therapy.6. The method of claim 4 , wherein said therapy is a compound.7. The method of claim 6 , wherein said compound is a small ...

Extended digital migraine diary

This document presents a system and method for analyzing migraine related sensor and diary data to permit the prediction of migraine headaches for individuals. A mobile device is adapted to collect and transmit to a server data content from sensors associated with the mobile device and self-reported data content indicative of contemporaneous environmental conditions and individual physical conditions when the individual is suffering from a migraine headache. The server uses the data content to develop predictive metrics indicative of a correlation between the migraine events and the sensor data. The predictive metrics will provide an alert to a designated individual if it is likely the individual will experience a migraine within a future time period.

Systems and methods for diagnosing a stroke condition

A method for estimating a likelihood of a stroke condition of a subject, the method comprising: acquiring clinical measurement data pertaining to said subject, said clinical measurement data including at least one of image data, sound data, movement data, and tactile data; extracting from said clinical measurement data, potential stroke features according to at least one predetermined stroke assessment criterion; comparing said potential stroke features with classified sampled data acquired from a plurality of subjects, each positively diagnosed with at least one stroke condition, defining a positive stroke dataset; and determining, according to said comparing, a probability of a type of said stroke condition, and a probability of a corresponding stroke location of said stroke condition with respect to a brain location of said subject.

SYSTEMS AND METHODS FOR DETECTING BRAIN-BASED BIO-SIGNALS

The current invention includes systems and methods for detecting, by a sensor including at least two electrodes, a multicomponent brain-based bio-signal in an internal tissue of a patient, digitizing, by at least one computer processor communicatively coupled to the sensor, the multicomponent brain-based bio-signal, isolating, by the at least one computer processor, a plurality of subcomponent signals from the digitized multicomponent brain-based bio-signal, comparing isolated data from one or more of the isolated sub component signals, by the at least one computer processor, to predetermined baseline data, and generating, by the at least one computer processor, at least one of an instruction to a machine and a visual diagnosis of a condition, in response to said comparing isolated data to baseline data. 1. A method comprising:detecting, by a sensor including at least two electrodes, a multicomponent brain-based bio-signal in an internal tissue of a patient;digitizing, by at least one computer processor communicatively coupled to the sensor, the multicomponent brain-based bio-signal;isolating, by the at least one computer processor, a plurality of subcomponent signals from the digitized multicomponent brain-based bio-signal;comparing isolated data from one or more of the isolated sub component signals, by the at least one computer processor, to predetermined baseline data; andgenerating, by the at least one computer processor, at least one of an instruction to a machine and a visual diagnosis of a condition, in response to said comparing isolated data to baseline data.2. The method of claim 1 , wherein the condition is a concussion. The present application claims the benefit of priority of U.S. Provisional Application No. 61/717,997 filed Oct. 24, 2012, and of U.S. Provisional Application No. 61/790,007, which are incorporated herein by reference.The present invention relates to methods of reading brain-based bio-signals. In non-limiting embodiments the present ...

MOTION SICKNESS STATE DETERMINATION SYSTEM, BIOLOGICAL INFORMATION ACQUISITION DEVICE, SURROUNDING ENVIRONMENT INFORMATION ACQUISITION DEVICE, MOTION SICKNESS STATE DETERMINATION DEVICE, AND MOTION SICKNESS STATE DETERMINATION METHOD

An object of the present technology is to accurately determine a motion sickness state of an individual subject. The present technology provides a motion sickness state determination system () that includes a first index acquisition unit () that acquires biological information of a subject as a first motion sickness state index, a second index acquisition unit () that acquires a second motion sickness state index on the basis of movement information regarding a movement of the subject and/or surrounding environment information perceived by the subject, and a motion sickness state determination unit () that determines whether or not the subject will be in a motion sickness state or is in the motion sickness state on the basis of the first motion sickness state index and the second motion sickness state index. Furthermore, the present technology also provides a motion sickness state determination device (), a biological information acquisition device (), and a surrounding environment information acquisition device () included in the system, and a motion sickness state determination method. 1. A motion sickness state determination system comprising:a first index acquisition unit configured to acquire biological information of a subject as a first motion sickness state index;a second index acquisition unit configured to acquire a second motion sickness state index on a basis of movement information regarding a movement of the subject and/or surrounding environment information perceived by the subject; anda motion sickness state determination unit configured to determine whether or not the subject will be in a motion sickness state or is in the motion sickness state on a basis of the first motion sickness state index and the second motion sickness state index.2. The motion sickness state determination system according to claim 1 , further comprising: a motion sickness state control unit configured to control the motion sickness state of the subject on a basis of a ...

Handheld Radio Device for Assessing Cognitive, Auditory, Visual, and Speech Function

A handheld radio device that incorporates within equipment typically carried by a first-responder but with added functionality which enables assessments of a subject's cognitive, auditory, visual, and speech function. In addition to providing two-way tactical radio functionality, the handheld radio device operates to generate haptic, audible, and visual stimuli, and then assess a subject utilizing the handheld radio device based on the subject's responses to the stimuli on the interfaces and sensors of the handheld radio device. Because this functionality is provided in equipment this is already typically carried by the first-responder, assessments that are more forward-deployed and closer to the point and time of injury, exposure, or period of interest can occur. 1. An apparatus for assessing cognitive , auditory , visual , and/or speech function , comprising:a handheld radio device having a body that includes at least an internal controller and an internal battery, wherein said body includes an integral microphone, vibrator, accelerometer, gyroscope, magnetometer, and global positioning system interface which are each operatively connected to said controller;a communications system integral with said body and connected to said controller, wherein said handheld radio device is configured to provide two-way tactical radio communication functionality that utilizes multiple VHF/UHF or cellular frequency bands through said communications system;a user talk interface integral with said body and connected to said controller, wherein said user talk interface is adapted to activate the integral microphone in response to predetermined action from a user;a sound interface integral with said body and connected to said controller, wherein said handheld radio device is configured to transduce electrical audio signals with said sound interface;at least one mechanical tactile interface integral with said body and connected to said controller, wherein said at least one mechanical ...

DEVICE AND METHODS FOR MOBILE MONITORING AND ASSESSMENT OF CLINICAL FUNCTION THROUGH SENSORS AND INTERACTIVE PATIENT RESPONSES

Methods and systems are disclosed for sensing and assessing a patients responses to tests using a device that may include tactile input, voice input, still image analysis, and responses to visual and auditory stimuli. In one example, a method includes obtaining interactive clinical assessment data using a remote client device and a computer-based control device, the method including providing on a display of a remote client device one or more test prompts for conducting an interactive clinical assessment, each displayed test prompt instructing a user to perform an action using the remote client device in response to the test prompt, and providing on the display of the remote client device one or more potential responses of actions that may be performed in response to the test prompt. 1. A method of obtaining interactive clinical assessment data using a remote client device and a computer-based control device , the method comprising:providing on a display of a remote client device one or more test prompts for conducting an interactive clinical assessment, each displayed test prompt instructing a user to perform an action using the remote client device in response to the test prompt; andproviding on the display of the remote client device one or more potential responses of actions that may be performed in response to the test prompt.2. The method of claim 1 , further comprising receiving input at the remote client device claim 1 , the input indicative of an action performed in response to a test prompt provided on the display of the remote client device.3. The method of claim 1 , further comprising sending response information from the remote client device claim 1 , the response information being indicative of input received at the remote client device in response to the one or more test prompts provided on the display of the remote client device.4. The method of claim 1 , further comprising receiving clinical tests at the remote device claim 1 , and wherein the one ...

Non-invasive Systems and Methods to Detect Cortical Spreading Depression for the Detection and Assessment of Brain Injury and Concussion

The present invention provides systems and methods for detection and diagnosis of concussion and/or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD/PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD/PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode/amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD/PID on the brain surface. 119-. (canceled)20. A head-mountable detection unit comprising:a head-net; anda high density array of electrodes incorporated into the head net, the electrodes being spaced about 0.5 cm and about 1.5 cm from one another.21. The head-mountable detection unit of claim 20 , wherein the electrodes are spaced about 1.0 cm apart from one another.22. The head-mountable detection unit of claim 20 , wherein the head-net is configured to noninvasively contact a scalp surface of a subject.23. The head-mountable detection unit of claim 22 , wherein the detection unit is capable of detecting concussion-based cortical spreading depression claim 22 , acute neurological injury-based cortical spreading depression and peri-infarct depolarization (CSD/PID) claim 22 , and cortical spreading depression associated with migraine auras in the subject.24. The head-mountable detection unit of claim 20 , wherein the head-net is selected from the group consisting of a stand-alone head-net claim 20 , a head-band ...

Automated Data Acquisition, Appraisal and Analysis in Noninvasive Rapid Screening of Neuro-Otologic Conditions Using Combination of Subject's Objective Oculomotor Vestibular and Reaction Time Analytic Variables

Ann automated data acquisition, appraisal and analysis in noninvasive rapid screening of neuro-otologic condition using combination of subject's objective oculomotor, vestibular and reaction time analytic variables, comprises the steps of: establishing an OVRT testing protocol for specific neuro-otologic condition which protocol included eye tracking aspects; coupling an eye tracker is coupled to subject; automatically establishing a region of interest for the eye tracker centered on the subject's pupils; conducting the OVRT testing protocol using pre-programmed/automated voice instructions to the subject; confirming that each test is performed within preset parameters including automated eye image evaluation and advising the clinician of testing which is outside of present parameters; and displaying a normalized composite test protocol score (0-1) on graphical progressive background. 1. Automated data acquisition , appraisal and analysis in noninvasive rapid screening of neuro-otologic condition using combination of subject's objective oculomotor , vestibular and reaction time analytic variables , comprising the steps of:Establishing an OVRT testing protocol for specific neuro-otologic condition which protocol included eye tracking aspects;Coupling an eye tracker is coupled to subject;Automatically establishing a region of interest for the eye tracker centered on the subject's pupils;Conducting the OVRT testing protocol; andDisplaying a composite test protocol score.2. The automated data acquisition claim 1 , appraisal and analysis according to wherein the conducting the OVRT testing protocol uses pre-programmed/automated voice instructions to the subject.3. The automated data acquisition claim 2 , appraisal and analysis according to claim 2 , further including the step of confirming that each test is performed within preset parameters including automated eye image evaluation and advising the clinician of testing which is outside of present parameters.4. The ...

Waveguide neural interface device

A waveguide neural interface device including: a neural device implantable in tissue and including an array of electrode sites that electrically communicate with their surroundings, in which the array of electrode sites includes at least one recording electrode site; and a waveguide, coupled to the neural device, that carries light along a longitudinal axis and includes a light directing element that redirects the carried light from the waveguide to illuminate selectively targeted tissue, in which at least a portion of the redirected light is directed laterally away from the longitudinal axis and the recording electrode site is configured to sample illuminated tissue. A method for assembling a waveguide neural interface device is also described.

SYSTEM AND METHOD FOR CONCUSSIVE IMPACT MONITORING

A system and a method for detecting mild traumatic brain injury (mTBI) includes a memory arrangement including stored brain data corresponding to electrical activity of a brain of a subject at locations in the brain during a first time period. In addition, the system includes a processor receiving the stored brain data and current brain data corresponding to electrical activity of the brain of the subject at the plurality of locations during a second time period, wherein the second time period is after the first time period. The processor generates a first set of phase synchrony measures (PSM) corresponding to frequency band-specific oscillatory phase synchrony of the stored brain data, and a second set of PSM corresponding to frequency band-specific oscillatory phase synchrony of the current brain data. The processor determines a likelihood of mTBI based on the first and second sets of PSM. The stored brain data may be a normative distribution of data of the electrical activity of the brain determined from a set of standards

SYSTEM AND METHOD FOR PREDICTING NEUROLOGICAL DISORDERS

A method and system for predicting neurological disorders is provided. The method comprises receiving videos of individuals and detecting Regions of Interest (ROI) in video frames. The method further comprises determining a Motion Vector (MV) for each ROI in a set of successive frames and comparing value of the determined MV with pre-stored values. Furthermore, the method comprises identifying a MV matching a pre-stored value thereby identifying a ROI and a frame corresponding to the identified MV, wherein the pre-stored value indicates onset of an expression. Also, the method comprises determining MVs for the identified ROI in subsequent sets of successive frames and comparing value of the determined MVs with a pre-stored value of MV corresponding to peak and offset of the indicated expression. The method further comprises identifying the frame corresponding to the peak and offset of the indicated expression and generating pictorial representation for predicting neurological disorders. 1. A method for predicting one or more neurological disorders via a processor configured to execute program instructions stored in a memory , the method comprising:receiving, via the processor, one or more videos of one or more individuals;splitting, via the processor, the one or more videos into one or more frames;detecting, via the processor, one or more regions of interest in each of the one or more frames; determining one or more features, related to one or more gait patterns, corresponding to each of the one or more regions of interest in a set of successive frames;', 'comparing values of the determined one or more features with corresponding pre-stored values of the one or more features of each of the one or more regions of interest; and', 'identifying a gait pattern of the one or more individuals based on the comparison, wherein at least one compared value matches a corresponding pre-stored value of at least one feature, and further wherein the matched pre-stored value of the ...

Methods for sensing or stimulating activity of tissue

Methods for sensing or stimulating electrical activity of brain tissue from within an animal vessel by placement of an intravascular device within an animal vessel to control an external device, the intravascular device being adapted to at least one of sense and stimulate activity of brain tissue located outside the vessel proximate the intravascular device.

Sudomotor function for peripheral diabetic neuropathy evaluation

A method for assessing sudomotor function of a patient for evaluating diabetic and autonomous neuropathy is disclosed. The method is performed in a system comprising electrodes intended to be placed on different regions of the patient body, and an adjustable DC source. The method includes applying on the electrodes DC voltage pulses of varying voltage values in order to stress sweat glands, the voltage pulses lasting given durations allowing the stabilization of electrochemical phenomena in the body, near the electrodes; collecting data representative of the current between the electrodes, and of the potential generated on the electrodes for the different DC voltages; from the data, computing results representative of the electrochemical skin conductance of the patient; reconciling the latter data with reference data obtained in the same conditions on patients identified as suffering or not from sudomotor, and identifying the patient as suffering or not from sudomotor dysfunction.

METHOD FOR PREDICTING AWAKENING IN A COMATOSE PATIENT AND COMPUTER-IMPLEMENTED METHOD THEREOF

The present invention relates to a method for predicting awakening in a comatose patient based on the progression of auditory discrimination during early stages of coma. EEG measures are acquired from the patient during two distinct periods when said patient is exposed to auditory stimuli comprising repeated standard and deviant sounds. The first period occurs when the comatose patient is in a hypothermia state and the second period occurs when the comatose patient is in a normal temperature state and preferably within 2-3 days from the onset of the coma. The present invention further relates to a computer-implemented method thereof. 1. A method for predicting awakening in a comatose patient based on auditory discrimination measured by an electroencephalography machine , the method comprising the following steps:a) exposing the comatose patient treated with hypothermia to auditory stimuli within the first 24 hours from the onset of coma, said auditory stimuli comprising repeated standard and deviant sounds;b) recording the patient's electrical activity in the form of electro-encephalographic data to measure the auditory evoked potential (AEP) for each standard sound and for each deviant sound of the auditory stimuli while said patient is in hypothermia state and allocating a first value which is informative of the degree of said auditory discrimination;c) exposing said patient to the same auditory stimuli as in step a) for the second time while said patient is in a normal temperature state;d) recording the patient's electrical activity in the form of electro-encephalographic data to measure the AEP for each standard sound and for each deviant sound of the auditory stimuli while said patient is in a normal temperature state and allocating a second value which is informative of the degree of said auditory discrimination; ande) comparing the first and second values to determine whether there is an improvement of auditory discrimination over time which is informative of ...

CONCUSSION/BALANCE EVALUATION SYSTEM AND METHOD

A balance testing apparatus includes a rigid bottom plate and a rigid top plate. At least three uni-axial load cells are coupled to the bottom plate and the top plate, and are configured to measure a set of predetermined parameters indicative of balance of an individual standing on the rigid top plate. 1. A balance testing apparatus , comprising:a rigid bottom plate;a rigid top plate;at least three uni-axial load cells coupled to the bottom plate and the top plate, the at least three uni-axial load cells configured to measure a set of predetermined parameters indicative of balance of an individual standing on the rigid top plate.2. The apparatus of claim 1 , further comprising:a processor, including data storage, coupled to each of the at least three uni-axial load cells adapted to collect the measured set of predetermined parameters indicative of balance of the individual;wherein the data storage includes an instruction set to enable the processor to correlate the measured set of predetermined parameters to the balance of the individual.3. The apparatus of claim 2 , further comprising a display device coupled to the processor configured to display the measured set of predetermined parameters in a desired format.4. The apparatus of claim 2 , wherein the processor is configured to administer one of the NFL test claim 2 , the SCAT3 test claim 2 , the BESS test claim 2 , and the modified BESS test.5. The apparatus of claim 3 , further comprising at least one accelerometer coupled to the bottom plate and configured to account for movement of the bottom plate relative to the top plate in both the X and the Y directions.6. The apparatus of claim 5 , wherein the processor claim 5 , the display device claim 5 , the load cells and the accelerometers are wirelessly coupled together.7. The apparatus of claim 1 , wherein the rigid top plate and the rigid bottom plate are formed from a composite material.8. The apparatus of claim 1 , wherein each of the uni-axial load cells is ...

WEARABLE GAIT MONITORING APPARATUS, SYSTEMS, AND RELATED METHODS

Eyewear or any other suitable wearable device may include one or more sensors for monitoring the gait of an individual. Information from the one or more sensors is analyzed to identify one or more medical conditions associated with the individual or to assess an individual's recovery from a particular injury or medical procedure. 1. A non-transitory computer-readable medium storing computer-executable instructions for:receiving, at a gait server, information obtained from at least one sensor worn adjacent the individual's head;using, by the gait server, the information to assess the gait of the individual;analyzing, by the gait server, the assessed gait using regression analysis techniques to determine whether the assessed gait includes one or more particular gait patterns that are associated with a particular medical condition; andin response to determining that the assessed gait includes the one or more gait patterns, generating an alert that the individual may have the particular medical condition.2. The non-transitory computer-readable medium of claim 1 , wherein the at least one sensor is embedded into a pair of glasses worn by the individual.3. The non-transitory computer-readable medium of claim 2 , wherein the at least one sensor is a gyroscope.4. The non-transitory computer-readable medium of claim 1 , wherein the step of using the information to assess the gait of the individual comprises:using the information to assess one or more movements of the individual's head as the individual ambulates; andusing the one or more movements of the individual's head to assess the gait of the individual.5. The non-transitory computer-readable medium of claim 1 , wherein the step of analyzing the assessed gait to determine whether the assessed gait includes one or more particular gait patterns that are associated with a particular medical condition comprises:using the information to assess one or more movements of the individual's head as the individual ambulates; ...

DIAGNOSTIC METHOD AND APPARATUS FOR BRAIN INJURY BASED ON EMG FREQUENCY POWER SPECTRA ANALYSIS

A method and a device for diagnosing brain injury (e.g. concussion) based on analysis of electromyogram (EMG) signals and presence of neurological modulation impairment of motor activity are described. The method consists of recording specific EMG signals under defined conditions, processing the acquired EMG signals, extracting the relevant information, and making diagnosis of brain injury and disorders that are associated with brain pathology. Specifically, the steps and device involved in the method include placing an EMG electrode set on the subject's body area, acquiring EMG signals from a subject's muscle(s) undergoing contraction, processing the acquired EMG signals using a signal processing algorithm that includes Fourier transformation. The resulting EMG data with a frequency domain (frequency power spectra) are then analyzed in comparison with databases stored in the device and used to determine anomaly of diagnostic value in the EMG power spectra from subjects. A diagnosis can be made based the altered EMG frequency power spectra that reflect the neurological modulation impairment of motor neurons. The diagnostic value, determination, management suggestions are displayed on the device. 1. A method for assessing a subject's neurological modulation of motor activities using a portable device , the method comprising:acquiring electromyogram (EMG) signals of the subject from a detection area of the body using an EMG sensor device operatively coupled to a portable base unit;processing the acquired EMG signals using the processor of the base unit and software to transform the EMG signals into EMG power data, and extracting quantitative features of the transformed EMG signals using at least one of linear and non-linear algorithms;comparing the subject's EMG power spectra and the quantitative features against those in at least one database; anddetermining when the subject has an abnormality or impairment in neurological modulation of motor activities that are ...

NEUROPHYSIOLOGICAL DATA ANALYSIS USING SPATIOTEMPORAL PARCELLATION

A method of analyzing neurophysiological data recorded from a subject is disclosed. The method comprises identifying activity-related features in the data, and parceling the data according to the activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain. The method further comprises comparing at least some of the defined capsules to at least one reference capsule, and estimating a brain function of the subject based on the comparison. 1. A system for analyzing neurophysiological data recorded from a brain of a subject , the system comprises a data processor configured for:identifying activity-related features in the data;parceling the data according to said activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain;comparing at least some of said defined capsules to at least one reference capsule; andestimating a brain function of the subject based on said comparison.2. The system of claim 1 , further comprising a controller connectable to a brain stimulation system and configured for controlling said brain stimulation system to apply local stimulation to the brain responsively to said estimated brain function.3. The system according to claim 2 , wherein said controller is configured to control said brain stimulation system to apply said local stimulation at one or more locations corresponding to a spatial location of at least one of said capsules.4. The system according to claim 2 , wherein said estimation of said brain function is executed repeatedly claim 2 , and said controller is configured to vary said local stimulation responsively to variations in said brain function.5. The system according to claim 1 , wherein said comparison comprises calculating claim 1 , for each of said at least some of said defined capsules claim 1 , a statistical score of a spatiotemporal vector corresponding to said capsule using multidimensional ...

METHOD AND SYSTEM FOR PROVIDING ELECTRICAL STIMULATION TO A USER

A method for providing electrical stimulation to a user as a user performs a set of tasks during a time window, the method comprising: providing an electrical stimulation treatment, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window; for each task of the set of tasks: receiving a signal stream characterizing a neurological state of the user; from the signal stream, identifying a neurological signature characterizing the neurological state associated with the task; and modulating the electrical stimulation treatment provided to the brain region of the user based upon the neurological signature, wherein modulating comprises delivering a portion of the set of portions of the electrical stimulation treatment to the brain region of the user, while maintaining an aggregate amount of the stimulation parameter of the treatment provided during the time window below a maximum limit. 1providing an electrical stimulation device at a head region of the user; and delivering a first portion of the set of portions of the electrical stimulation session to the brain region of the user in association with a first event of the set of events,', 'delivering a second portion of the set of portions of the electrical stimulation session to the brain region of the user in association with a second event of the set of events, and', 'providing at least one resting period between the first portion and the second portion of the electrical stimulation session, while maintaining an aggregate amount of the stimulation parameter of the electrical stimulation session provided to the user during the time window below a maximum limit., 'with the electrical stimulation device, providing an electrical stimulation session, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window, wherein providing the electrical stimulation session comprises. A method for ...

Method and system for providing electrical stimulation to a user

A method for providing electrical stimulation to a user as a user performs a set of tasks during a time window, the method comprising: providing an electrical stimulation treatment, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window; for each task of the set of tasks: receiving a signal stream characterizing a neurological state of the user; from the signal stream, identifying a neurological signature characterizing the neurological state associated with the task; and modulating the electrical stimulation treatment provided to the brain region of the user based upon the neurological signature, wherein modulating comprises delivering a portion of the set of portions of the electrical stimulation treatment to the brain region of the user, while maintaining an aggregate amount of the stimulation parameter of the treatment provided during the time window below a maximum limit.

WEARABLE MENTAL STATE MONITOR COMPUTER APPARATUS, SYSTEMS, AND RELATED METHODS

A computer-implemented method of assessing the metal state of an individual by: (1) providing the individual with a wearable device (e.g., eyewear) that includes one or more sensors for assessing the mental state of the individual, (2) using information from one or more of the sensors to assess the mental state of the individual; and (3) informing the individual or a third party of the individual's mental state. In various embodiments, the method further involves using the wearable device to determine one or more environmental factors that are related to the individual's mental state. For example, the method may involve determining (e.g., from one or more images taken using the wearable device) that the individual is frequently in a stressed emotional state when a particular person is present, when the individual is engaged in a particular activity, and/or when the wearer experiences a certain internal or external context. 1. A computer-implemented method of assessing the mental state of a wearer of eyewear comprising one or more sensors coupled to the eyewear , the one or more sensors being adapted to detect one or more characteristics of the wearer of the eyewear , wherein the one or more characteristics are associated with the wearer's mental state , the method comprising: i. pupil size,', 'ii. heart rate,', 'iii. perspiration rate,', 'iv. respiration rate,', 'v. physical movement, and', 'vi. brainwave activity;, 'a. receiving, by a processor, one or more signals from the one or more sensors, wherein each of the one or more signals relates to at least one characteristic associated with the wearer, the at least one characteristic being selected from a group consisting ofb. analyzing, by a processor, the one or more received signals to determine the at least one characteristic;c. facilitating, by a processor, determination of a mental state of the wearer based, at least in part, on the at least one characteristic; andd. associating, by a processor, the mental state ...

APPARATUS AND RELATED METHOD TO FACILITATE TEST VIA A COMPUTING DEVICE

This disclosure relates to a device to mechanically and electrically connect with a touch screen computing device, such as a tablet computer. The device can include a platform that can be moved into and out of physical contact with a surface of a touch screen. During engagement with the surface, the moveable platform electrically interacts with the touch screen (e.g., via capacitive coupling) to enable detection by the touch screen of contact members (e.g., pegs) even in the absence of user contact with the pegs. 1. An apparatus comprising:a first housing portion comprising a test fixture having a base dimensioned and configured to overlay at least a display screen portion of a computing device, an arrangement of receptacles being formed in the test fixture and configured to receive contact members within the receptacles as to render each of the contact members independently detectable by the computing device while each respective contact member is received in the receptacles.2. The apparatus of claim 1 , wherein the display screen portion of the computing device includes a touch screen to detect each of the contact members while received in the receptacles while the test fixture overlays the touch screen and in the absence of direct contact by a user.3. The apparatus of claim 1 , further comprising a second housing portion connected to the first housing portion and configured to attach the first housing portion with respect to the display screen portion of the computing device.4. The apparatus of claim 3 , wherein the second housing portion includes a contact surface to mechanically and electrically connect the test fixture with a body of the computing device.5. The apparatus of claim 3 , wherein the base of the first housing portion is pivotably connected to the second housing portion to enable the base to be moved into and out of engagement with the touch screen of the computing device.6. The apparatus of claim 5 , further comprising a mechanical hinge to ...

Tremor Reduction Device

A wearable tremor reduction device reduces tremor by internally generating forces which cancel or reduce the magnitude force of the tremor experienced by the person wearing the device. The device may be worn on a wrist, arm, ankle or leg. The device has a plurality of housing members which are flexibly connected together. Each housing member contains a mass which is translatable along an axis between a proximal limit and a distal limit, and a neutral position midway between the proximal limit and the distal limit. Following imposition of a force having a component along the axis, a biasing means returns the mass to the neutral position. 1. A tremor reduction device worn by a user , the device comprising:a plurality of housing members flexibly connected together, each housing member containing a mass which is translatable along an axis between a proximal limit and a distal limit, and a neutral position midway between the proximal limit and the distal limit, wherein, following imposition of a force having a component along the axis, a biasing means returns the mass to the neutral position.2. The tremor reduction device of wherein the plurality of housing members comprise:a first housing member comprising a first proximal sidewall and a first distal sidewall, the first proximal sidewall and the first distal sidewall in opposite facing spaced-apart relation, a first mass disposed between the first proximal side wall and the first distal side wall, the first mass comprising a first proximal side and a first distal side, a first proximal spring disposed between the first proximal side wall and the first proximal side of the first mass, and a first distal spring disposed between the first distal side wall and the first distal side of the first mass;a second housing comprising a second proximal sidewall and a second distal sidewall, the second proximal sidewall and the second distal sidewall in opposite facing spaced-apart relation, a second mass disposed between the second ...

Thermal imaging system

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.

Methods for detecting abnormalities and degenerative processes in soft tissue using magnetic resonance imaging

The present invention provides methods to detect degenerative processes and abnormalities in soft tissues at high spatial resolution, high signal-to-noise ratio and short scanning times, based on quantitative tissue properties. These methods might provide a useful tool to detect and assess abnormalities in soft tissues and to monitor disease progression.

Compositions and Methods for Assessing Risk of Autism Spectrum Disorder During Early Childhood

The invention includes an early detection system for ASD that combines the assessment of various factors and comorbid conditions to accurately generate a prediction model for assessing the degree of ASD. 1. A method for assessing the severity of ASD in a subject , the method comprising:a. determining the incidence of at least one medical condition in a subject,b. comparing the incidence of the at least one medical condition with a comparator control, andc. assessing the subject's degree of ASD severity when the level of the at least one medical condition is present at a statistically significant amount when compared with the comparator control.2. The method of claim 1 , wherein the at least one medical condition is selected from the group consisting of unspecified hearing loss claim 1 , Otitis Media claim 1 , epilepsy claim 1 , lack of coordination claim 1 , influenza with other manifestation claim 1 , patent ductus arteriosus claim 1 , dysphagia claim 1 , abdominal pain claim 1 , convulsion claim 1 , ear pain claim 1 , teething syndrome claim 1 , delayed milestone claim 1 , weight/metabolism issue claim 1 , disorder due to short gestation/low weight claim 1 , lingering issue from labor complications claim 1 , respiratory abnormalities claim 1 , asthma claim 1 , delay in development claim 1 , preterm infants claim 1 , rash and other non-specified skin eruption claim 1 , constipation claim 1 , diarrhea claim 1 , contact dermatitis and other eczema claim 1 , atopic dermatitis and related conditions claim 1 , lack of normal physiological development claim 1 , vomiting claim 1 , acute laryngitis and trachetitis claim 1 , feeding difficulty claim 1 , colitis claim 1 , viral infection claim 1 , acute pharyngitis claim 1 , cough claim 1 , GERD claim 1 , fever claim 1 , acute upper respiratory infection claim 1 , and any combination thereof.3. The method of claim 1 , wherein the subject is a child.4. The method of claim 3 , wherein the child is less than 6 months old.5. The ...

WORKSTATION TO IMPROVE EDUCATION AND CLINICAL INTERVENTIONS FOR INDIVIDUALS WITH MILD TO SEVERE LEARNING DISABILITIES

A workstation for neurobiological disorder health professionals that aids professionals tracking, evaluating and archiving clinical and educational progress through a web application using 360-degree video. The invention allows for organized communication between internal and external resources of an institution to tackle patient/student needs that merit immediate attention from specialists either in an individual or group setting. For additional expertise in acute cases, the institution can get access to consult with specialists around the world through the invention's directory of professionals. The invention allows clinical supervisors to train staff and ensure consistency in therapeutic interventions and evaluations, as well as supervisors in a school setting for consistency in educational programming. The invention also accelerates staff training time through targeted supervision. 1. A workstation for educators and clinical professionals comprising:a workspace module comprising a plurality of cubicles;a tube located in the middle of said workspace module comprising an immersive camera;an Internet access point;a plurality of computers; at least one processor;', 'a storage module;', 'a memory module;', 'a video capturing module; and', make video calls;', 'record video;', 'tag video., 'a software module configured to], 'wherein each computer of said plurality of computers is connected to a secure cloud server comprising2. The workstation of claim 1 , wherein said immersive camera is a 360-degree camera.3. The workstation of claim 1 , wherein said plurality of computers comprises desktop computers claim 1 , laptop computers claim 1 , or tablet computers.4. The workstation of claim 1 , further comprising a wireless headset.5. The workstation of claim 1 , wherein said software module is further configured to stream live video.6. The workstation of claim 1 , wherein said secure web server further comprises a machine learning software module configured to collect video ...

SYSTEMS AND METHODS FOR NEURO-EGG SYNCHRONIZATION THERAPY

Described are methods, devices, and systems for a novel, inexpensive, easy to use therapy for a number of disorders. Described are methods and devices to treat disorders that involves no medication. Methods and devices described herein use alternating magnetic fields to gently “tune” the brain and affect mood, focus, and cognition of subjects. 129.-. (canceled)30. A device for applying a varying magnetic field to a head of a human subject , the device being configured to receive at least a portion of the head of the human subject , and comprising:a) a first permanent magnet; andb) a controller operable to control rotation of the permanent magnet, the rotation being relative about an axis parallel to at least a portion of the head and being at a harmonic frequency of a frequency within a specific EEG band, thereby generating a varying magnetic field.31. The device of claim 30 , wherein the specified EEG band is an Alpha band claim 30 , a Beta band claim 30 , or a Theta band.32. The device of further comprising:a) a helmet with the first permanent magnet therein, that receives the portion of the head of the human subject; andb) a second permanent magnet.33. The device of claim 32 , wherein the controller subunit is coupled to the second permanent magnet and operable to rotate the second permanent magnet about a second axis that is parallel to the axis claim 32 , and wherein the varying magnetic field treats drug addiction or substance abuse.34. The device of claim 33 , wherein the controller subunit is operable to control rotation of the second permanent magnet to be at the frequency within the specific EEG band.35. The device of claim 34 , wherein the specified EEG band is an Alpha band claim 34 , a Beta band claim 34 , or a Theta band.36. The device of further comprising a subunit configured to determine an intrinsic frequency of the subject within the specified EEG band or receive the intrinsic frequency of the subject within the specified EEG band.37. The device ...

DEVICE, SYSTEM AND METHOD FOR MONITORING NEUROLOGICAL FUNCTIONAL STATUS

A device for measuring eyelid movement in a human subject comprises a housing, at least one stimulator mounted to the housing, and a camera. The at least one stimulator is configured to provide stimulus to one or both eyes of the subject. The camera is configured to collect information related to movement of one or both eyes of the subject. The device also includes a user interface that is configured to control the at least one stimulator and display information collected by the camera. 1. A method for detecting changes associated with an eye generated in response to impaired neurological function , the method comprising:when impaired neurological function is suspected in a subject, stimulating at least one facial region of a subject using at least one stimulator so as to cause an involuntarily blink response in the subject;measuring at least one parameter of the response from one or both eyes resulting from the stimulating step; anddisplaying information related to the at least one parameter.2. The method of claim 1 , wherein the at least one parameter comprises individual latency of one or both eyes of the subject.3. The method of claim 1 , wherein the at least one parameter comprises a differential latency between both eyes of the subject.4. The method of claim 1 , wherein the at least one parameter comprises counting oscillations of one or both eyes of the subject.5. The method of claim 1 , wherein the at least one parameter comprises measuring the tonic lid position of one or both eyes of the subject.6. The method of claim 1 , wherein the at least one parameter comprises changes in individual latency claim 1 , differential latency claim 1 , oscillations claim 1 , and changes in tonic lid position.7. The method of claim 1 , further comprising the steps of:comparing the at least one parameter to the at least one parameter measured at baseline; anddisplaying information related to at least one difference between the at least one parameter and the at least one ...

Systems and methods for analyzing concussion biomarkers

The various examples of the present disclosure are directed towards systems and methods for diagnosing brain health. An exemplary system includes a microscope, a processor, and a memory. The microscope outputs image data of a cornea of a patient. The memory has a plurality of stored code sections, which, when executed by the processor, include instructions for analyzing cornea image data to determine brain health. The instructions begin with receiving cornea image data from the microscope. The instructions then provide for determining at least one marker from the received cornea image data. The instructions then provide for outputting a brain health diagnosis based on the at least one marker.

SYSTEMS AND METHODS FOR TREATING A PSYCHIATRIC DISORDER

Systems and methods for treating a subject with a psychiatric disorder are provided in which a therapy session is conducted. In the therapy session, each respective expression image in a plurality of expression images is sequentially displayed. Each expression image is independently associated with an expression. The successive display of images is construed as a tiled series of expression image subsets, each consisting of N expression images. Upon completion of the display of each respective subset, the user is challenged as to whether the first and the last images in the respective subset exhibit the same emotion. A score is determined for the respective subset based on whether the subject learned to respond correctly. The number of images in each subset is adjusted to a new number based on these scores. A treatment regimen is prescribed to the subject for the psychiatric disorder based at least in part on the scores. 1. A computing system , comprising:one or more processors;memory; andone or more programs, wherein the one or more programs are stored in the memory and are configured to be executed by the one or more processors to treat a subject in need of treatment of a psychiatric disorder, the one or more programs including instructions for: i) sequentially displaying each respective expression image in a plurality of expression images for a predetermined amount of time, the plurality of expression images comprising a plurality of subsets of expression images, wherein each expression image in the plurality of expression images is (a) independently associated with a respective expression in a set of expressions, (b) engineered to display a predetermined intensity of the respective expression on an intensity scale that ranges from low intensity to high intensity of the respective expression and (c) induces human amygdala activation,', 'ii) responsive to completion of each respective expression image subset within the plurality of expression images, receiving a ...

LABEL-FREE SINGLE AND MULTI-PHOTON FLUORESCENCE SPECTROSCOPY TO DETECT BRAIN DISORDERS AND DISEASE: ALZHEIMER, PARKINSON AND AUTISM FROM BRAIN TISSUE, CELLS, SPINAL FLUID AND BODY FLUIDS

A label free single or multi-photon optical spectroscopy for measuring the differences between the levels of fluorophores from tryptophan, collagen, reduced nicotinamide adenine dinucleotide (NADH), and flavins exist in brain samples from a of Alzheimer's disease (AD) and in normal (N) brain samples with label-free fluorescence spectroscopy. Relative quantities of these molecules are shown by the spectral profiles of the AD and N brain samples at excitation wavelengths 266 nm, 300 nm, and 400 nm. The emission spectral profile levels of tryptophan and flavin were much higher in AD samples, while collagen emission levels were slightly lower and NADH levels were much lower in AD samples. These results yield a new optical method for detection of biochemical differences in animals and humans for Alzheimer's disease. 1. Method of detecting brain disorders and disease comprising the steps ofcollecting a sample of cells and/or tissue from a group consisting of brain tissue, eye fluid, body fluid and/or spinal fluid containing molecules found in a brain being examined (AZ) and from a normal brain (N);exposing and exciting said molecules to selected wavelengths within the range of 200-800 nm by 1 PEF using a cw lamp, LED, laser diodes and Supercontinuum and/or by 700 nm to 1200 nm ultrafast laser pulses (30 to 300 fs) by 2 PEF and 3 PEF;detecting emission of fluorescence from the excited molecules;examining fluorescence peaks of each of tryptophan, NADH, flavins and collagen;comparing intensity levels of excitation and emission spectra for tryptophan, collagen, NADH and flavin; and [{'br': None, 'i': 'N', 'Tryptothan AD>'}, {'br': None, 'i': 'N', 'Collagen AD˜'}, {'br': None, 'i': 'H N', 'NAD>AD.'}], "establishing a diagnosis of Alzheimer's disease when the fluorescence intensity levels from a brain being examined (AD) and a normal brain (N) satisfy at least the following relationships:"}2. A method as defined in claim 1 , wherein exposure wavelengths cover the range of 260 ...

Implantable Devices and Related Methods for Monitoring Properties of Cerebrospinal Fluid

Embodiments of the present disclosure provide an implantable device for monitoring properties of cerebrospinal fluid of a patient. In one embodiment, the device may include a housing, a processor, a support member, one or more sensors, and a data storage. The sensors may be in communication with the processor and configured to detect one or more properties of cerebrospinal fluid. The device may be configured for transmitting the data and receiving instructions by an operator for the delivery of a therapeutic agent or imaging agent from a reservoir disposed within the housing in operable communication with a pump. 1. A method for implanting a device for monitoring properties of cerebrospinal fluid of a patient , the method comprising:attaching a housing of the device to the patient;moving at least a portion of a support member of the device relative to the housing, the support member extending from the housing; andpositioning one or more sensors of the device within a target region of the patient, the one or more sensors configured to detect one or more properties of cerebrospinal fluid.2. The method of claim 1 , wherein attaching the housing to the patient comprises:positioning the housing at least partially within a hole formed in a cranium of the patient;and attaching the housing to the cranium.3. The method of claim 1 , wherein attaching the housing to the patient comprises:positioning the housing at least partially within a hole formed in a spine of the patient; andattaching the housing to the spine.4. The method of claim 1 , wherein the support member is flexible claim 1 , and wherein moving the at least a portion of the support member relative to the housing comprises bending the at least a portion of the support member.5. The method of claim 1 , wherein positioning the one or more sensors within the target region comprises positioning the one or more sensors within an epidural space of the patient.6. The method of claim 1 , wherein positioning the one or more ...

SYSTEMS AND METHODS FOR BRAIN ACTIVITY INTERPRETATION

A method includes receiving electroencephalographic (EEG) signal data recordings collected from a plurality of individuals via at least one EEG monitoring device. An optimized plurality of wavelet packet atoms is constructed based on the EEG signal data recordings and a mother wavelet. The optimized plurality of wavelet packet atoms is reordered to obtain an optimal reordered set of wavelet packet atoms. The optimal reordered set of wavelet packet atoms is normalized to obtain an optimal normalized set of wavelet packet atoms that is representative of brain activities of the plurality of individuals. A particular EEG signal data recording of a particular individual is received, which is projected onto the optimal normalized set of wavelet packet atoms to obtain an individual-specific set of projections for the particular individual on the optimal normalized set of wavelet packet atoms. A brain activity representation of the particular individual is generated based on the individual-specific set of projections. 1. A method , comprising: 'wherein the at least one electrode combination comprises a recording electrode and a reference electrode that are applied to particular points on a head of each individual from the plurality of individuals;', 'receiving, by a processor, a plurality of electroencephalographic (EEG) signal data recordings collected from a plurality of individuals via at least one electrode combination of at least one EEG monitoring device;'}constructing, by the processor, an optimized plurality of wavelet packet atoms based on the plurality of EEG signal data recordings and a mother wavelet;reordering, by the processor, the optimized plurality of wavelet packet atoms to obtain an optimal reordered set of wavelet packet atoms;normalizing, by the processor, the optimal reordered set of wavelet packet atoms to obtain an optimal normalized set of wavelet packet atoms that is representative of a plurality of brain activities of the plurality of individuals; ...

ACTIVITY ASSISTANCE SYSTEM

An activity assistance system includes a video camera arranged to acquire video of a person performing an activity, an output device configured to output human-perceptible prompts, and an electronic processor programmed to execute an activity script. The script comprises a sequence of steps choreographing the activity. The execution of each step includes presenting a prompt via the output device and detecting an event or sequence of events subsequent to the presenting of the prompt. Each event is detected by performing object detection on the video to detect one or more objects depicted in the video and applying one or more object-oriented image analysis functions to detect a spatial or temporal arrangement of one or more of the detected objects. Each event detection triggers an action comprising at least one of presenting a prompt via the output device and and/or going to another step of the activity script. 1. An activity assistance system comprising:a video camera arranged to acquire video of a person performing an activity;an output device configured to output human-perceptible prompts; andan electronic processor programmed to execute an activity script comprising a sequence of steps choreographing the activity wherein the execution of each step includes presenting a prompt via the output device and detecting an event or sequence of events subsequent to the presenting of the prompt;wherein each event is detected by performing object detection on the video to detect one or more objects depicted in the video delineated by bounding boxes or by pixel boundaries of the respective one or more objects and applying one or more object-oriented image analysis functions to detect a spatial or temporal arrangement of one or more of the detected objects; andeach event detection triggers an action comprising at least one of presenting a prompt via the output device and and/or going to another step of the activity script.2. The activity assistance system of wherein the ...

Label-Free Single and Multi-Photon Fluorescence Spectroscopy to Detect Brain Disorders and Diseases: Alzheimer, Parkinson, and Autism From Brain Tissue, Cells, Spinal Fluid, and Body Fluids

A label free single or multi-photon optical spectroscopy for measuring the differences between the levels of fluorophores from tryptophan, collagen, reduced nicotinamide adenine dinucleotide (NADH). and flavins exist in brain samples from a of Alzheimer's disease (AD) and in normal (N) brain samples with label-free fluorescence spectroscopy. Relative quantities of these molecules are shown by the spectral profiles of the AD and N brain samples at excitation wavelengths 266 nm, 300 nm, and 400 nm. The emission spectral profile levels of tryptophan and flavin were much higher in AD samples, while collagen emission levels were slightly lower and NADH levels were much lower in AD samples. These results yield a new optical method for detection of biochemical differences in animals and humans for Alzheimer's disease.

Computational User-Health Testing

Methods, apparatuses, computer program products, devices and systems are described that carry out accepting user brain activity measurement data; selecting at least one user-health test function at least partly based on the user brain activity measurement data; and applying the at least one user-health test function to at least one interaction between at least one user and at least one device-implemented application. 159-. (canceled)60. A method comprising:providing instructions for performing at least one user-health test function in at least one memory associated with at least one computing device, the at least one user-health function including at least one speech test function;executing at least one application on the at least one computing device, the at least one application including at least one of a game, a productivity application, a security application, a telephony application, a video communications application, a videoconferencing application, or a cell phone application;electronically activating the at least one speech test function in response to a user command from at least one user to open the at least one application;electronically selecting the at least one speech test function including at least obtaining brain activity measurement data associated with the at least one user, electronically analyzing the obtained brain activity measurement data, and selecting the at least one speech test function based at least partly on the analysis; and electronically generating a display of at least one picture;', 'prompting speech of the at least one user in response to the displayed at least one picture;', 'electronically accepting prompted user speech data of the at least one user during the at least one interaction with the at least one application;', 'electronically analyzing the prompted user speech data using at least speech recognition for at least one of syntactic complexity, fluency, phrase length, rate of speech, or grammar; and', "determining at ...

Information Processing System

An information processing system visualizes brain states to optimize rehabilitation programs for rapid feedback of their effects to a patient and healthcare staff, to thereby promote the efficiency of rehabilitation. An embodiment of the system includes: a storage section that stores test-result brain-state relationship information associating results of activities of multiple examinees subjected to predetermined tests with brain states of the examinees; an input section that accepts a first test result as the result of the activity of a first examinee subjected to the predetermined tests; a control section that estimates the brain state from the first test result on the basis of the test-result brain-state relationship information; and an output section that outputs the estimated brain state.

System And Method For Imaging Myelin

The present invention provides a system and method for detecting myelin and myelin-related disease. For example, the invention is based upon the finding that the combined reflectance of an administered multi-wavelength laser light specifically detects myelinated fibers. It is demonstrated herein that the present system and method effectively detects myelin, myelin defects, and myelin pathology. 1. A method for imaging myelin comprisingadministering a multi-wavelength laser light to a region of interest in a subject;collecting the reflected light from the sample, wherein the collected reflected light is indicative of myelin in the region of interest; anddetecting the reflected light at each wavelength of the administered multi-wavelength laser light.2. The method of claim 1 , further comprising constructing a plurality of single-wavelength images claim 1 , each single-wavelength image based on the detected reflected light at each wavelength claim 1 , and combining the plurality of single-wavelength images to form a multi-wavelength image.3. The method of claim 1 , wherein the method identifies Nodes of Ranvier in a myelinated axon.4. The method of claim 1 , wherein the method identifies Schmidt-Lanterman incisures in a myelinated axon.5. The method of claim 1 , wherein the region of interest is in a body tissue selected from the group consisting of brain claim 1 , spinal cord claim 1 , and peripheral nerve.6. The method of claim 1 , wherein the method detects myelin at a depth of about 400 μm.7. The method of claim 1 , wherein the intensity of the multi-wavelength laser light is about 200-400 μW.8. The method of claim 1 , wherein the multi-wavelength laser light comprises at least three different wavelengths.9. The method of claim 1 , wherein the multi-wavelength laser light comprises the wavelengths of 488 nm claim 1 , 561 nm claim 1 , and 633 nm.10. The method of claim 1 , wherein the method identifies the subject as having a myelin-related disorder selected from ...

SYSTEM AND METHOD FOR AUTOMATED DETECTION OF NEUROLOGICAL DEFICITS

The disclosed embodiments provide systems and methods for predicting presence of one or more neurological deficits. The system may include a microphone, a camera, one or more memory devices storing instructions, and one or more processors configured to execute the instructions to extract audio information including a period density entropy coefficient and a mel frequency cepstral coefficient from an audio feed received from the microphone. Additionally, the instructions may cause the processor to determine position and depth information of eye movement from a video feed received from the camera and detect features of interest including facial landmarks, spatial orientation of limbs, and positional information of limb movements from the video feed. The one or more processors may further extract the features of interest from the video feed and process the extracted features of interest by aligning the extracted features of interest to a common reference. 1. A system for predicting presence of one or more neurological deficits , comprising:a microphone;a camera;one or more memory devices storing instructions; and extract audio information including a period density entropy coefficient and a mel frequency cepstral coefficient from an audio feed received from the microphone;', 'determine position and depth information of eye movement from a video feed received from the camera;', 'detect features of interest including facial landmarks, spatial orientation of limbs, and positional information of limb movements from the video feed;', 'extract the features of interest from the video feed;', 'process the extracted features of interest by aligning the extracted features of interest to a common reference;', 'generate a set of coordinates representing the features of interest;', 'generate intensity-based features including a histogram of oriented gradients representing the extracted features of interest;', 'provide the audio information, the position and depth information of eye ...

METHOD OF EARLY DETECTION OF MULTIPLE SCLEROSIS

A method of early detection of multiple sclerosis (MS) in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. Then, a health detection function is applied to this dataset that, in response to the level of activity change and the speed of activity change, predicts or detects MS in the animal. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Another embodiment uses a Fourier transform on a circle and a linear combination. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals. 1. A method of early detection of multiple sclerosis (MS) in an animal in a vivarium comprising the steps of:(a) selecting a single “activity drop metric” with an associated scalar “activity drop value”;(b) selecting an “MS health detection function” whose input comprises an “animal health dataset” and whose output comprises a likelihood scalar representing the likelihood that the animal has MS;(c) collecting a nightly activity scalar of the animal repeatedly and continually for a night and placing the nightly activity scalar into a set of “nightly activity data”;(d) identifying automatically three consecutive time regions in the nightly activity data: a “high activity region,” an “activity drop region,” and a “low activity region”;(e) applying the activity drop metric to the three consecutive regions, generating a nightly activity drop value;(f) adding the nightly activity drop value into the animal health dataset, wherein the animal health dataset comprises the resulting nightly activity drop values ...

METHOD OF MEASURING EFFICACY OF TREATMENT FOR MULTIPLE SCLEROSIS

A method of measuring efficacy of treatment of multiple sclerosis (MS) in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals or a standard of care to determine efficacy. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Another embodiment uses a Fourier transform on a circle and a linear combination. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals. 1. A method of measuring efficacy of a first treatment of multiple sclerosis (MS) in an animal in a vivarium comprising the steps of:(a) selecting a single “activity-drop metric” with an associated scalar “activity-drop value”;(b) selecting a “MS health detection function” whose input comprises an animal health dataset and whose output comprises an animal health severity scalar;(c) collecting an activity scalar of the animal repeatedly and continually for a night: a set of “nightly activity data”;(d) identifying automatically three consecutive time regions in the nightly activity data: a “high-activity region,” an “activity-drop region,” and a “low-activity region”;(e) applying the activity-drop metric to the three consecutive regions, generating a nightly activity-drop value;(f) adding the nightly activity-drop value into the “animal health dataset,” wherein the animal health dataset comprises the resulting nightly activity-drop values;(g) applying the MS health detection function to the animal health dataset, generating an animal health severity scalar for each iteration;(h) ...

Method of predicting severity of multiple sclerosis

A method of predicting severity of multiple sclerosis (MS) in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. Then, an MS severity index function is applied to this dataset that, in response to the level of activity change and the speed of activity change, predicts or measures severity of MS in the animal. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Another embodiment uses a Fourier transform on a circle and a linear combination. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.

METHODS AND APPARATUS TO FACILITATE CONCUSSION SCREENING

Methods and apparatus to facilitate concussion screening are disclosed. Example apparatus disclosed herein include a housing, a mobile device bracket, a first mirror, a second mirror, and a light source. The housing has a viewing port. The mobile device bracket is disposed in the housing and configured to support a mobile device that has a display and a camera. The first mirror is disposed in the housing to reflect the display toward the viewing port. The second mirror is disposed in the housing to reflect the viewing port toward the camera. The light source is disposed in the housing. 1. An apparatus comprising:a housing having a viewing port;a mobile device bracket disposed in the housing and configured to support a mobile device, the mobile device having a display and a camera;a first mirror disposed in the housing to reflect the display toward the viewing port;a second mirror disposed in the housing to reflect the viewing port toward the camera; anda light source disposed in the housing.2. The apparatus of claim 1 , wherein the light source comprises a focused red light emitting diode.3. The apparatus of claim 1 , further comprising a red light filter to filter light received by the camera.4. The apparatus of claim 1 , wherein the light source comprises a diffused blue light emitting diode.5. The apparatus of claim 4 , further comprising a potentiometer to regulate an intensity of the diffused blue light emitting diode.6. The apparatus of claim 1 , wherein the housing comprises a side wall claim 1 , the side wall having a mobile device port to insert the mobile device into the mobile device bracket.7. The apparatus of claim 1 , wherein the housing comprises a first sloped wall and a second sloped wall claim 1 , the first sloped wall supporting the first mirror claim 1 , and the second sloped wall supporting the second mirror.8. An apparatus comprising:a stimulator to provide a visual stimulus to a patient eye;an image capturer to capture visual data of the ...

SYSTEM FOR PROCESSING IMAGES TO DETECT PROPERTIES OF SKELETAL MUSCLE

Machine readable instructions, a data processing apparatus and a method are provided to determine one or more properties of motor units of skeletal muscle by analyzing a time series of Magnetic Resonance, MR, images representing a slice of a body part to identify signal voids in one or more images of the series. A comparison of at least one characteristic of the identified signal voids in the images is performed with a control data set of MR images produced by applying a controlled stimulus to a motor nerve to establish inherent characteristics of signal voids corresponding to motor units of skeletal muscle. Properties of candidate motor units are analyzed to confirm or reject them as motor units and at least one of: a firing frequency of at least one of the confirmed motor units, a size of at least one of the confirmed motor units, a number of confirmed motor units in a given image area or a shape of at least one of the confirmed motor units is determined. 1. Machine readable instructions stored on a non-transitory machine readable medium , the machine readable instructions upon execution to cause processing circuitry to:receive a time series of Magnetic Resonance, MR, images representing a slice of a body part;analyze the time series of images to identify one or more signal voids in one or more images of the series, a signal void being a localized region of signal attenuation;correlate the identified signal voids with candidate motor units of skeletal muscle, wherein the correlation comprises performing a comparison of at least one characteristic of the identified signal voids in the images with a control data set of MR images produced by applying a controlled stimulus to a motor nerve in control subjects to establish inherent characteristics of signal voids corresponding to motor units of skeletal muscle, the comparison to generate confirmed motor units; andanalyze properties of candidate motor units validated via the comparison as confirmed motor units and ...

SYSTEMS AND METHODS FOR GENERATING DISTRACTORS IN LANGUAGE LEARNING

Disclosed are systems, methods, and products for language learning software that automatically extracts text from resources using various natural-language processing features, which can be combined with custom-designed learning activities to offer a needs-based, adaptive learning methodology. The system may receive a text, extract keywords pedagogically valuable to non-native language learning, assign a difficulty score to the text using various linguistic attributes of the text, generate a list of potential distractors for each keyword related to a resource to implement in learning activities. Distractors may be of various types, which are dynamically selected from a distractor store depending on a learning activity chosen to meet a learner's needs. Distractors may vary in difficulty, and may be dynamically selected based on a learner's overall proficiency or based on a learner's abilities in specific language skills. 1. A computer-implemented method comprising: wherein the keyword store is configured to store metadata associated with each respective target word, and', 'wherein the metadata associated with each respective target word in the keyword word store indicates the word difficulty score of the respective target word;, 'automatically selecting, by a computer, from a keyword store, a set of target words stored in the keyword store, each respective target word having a word difficulty score based upon one or more skill scores of a learner-record stored in a learner database,'}identifying, by the computer, in a dictionary source, a plurality of words having an edit distance based upon a target word, wherein the edit distance of a word is an amount of letter-insertions and letter-deletions required for the word to be the target word; andgenerating, by the computer, at least one distractor comprising one or more words of the plurality of words, wherein the edit distance of each respective word in the at least one distractor satisfies an edit distance amount ...

Method for Assessment of Cerebrovascular Regulation

A system device and method are presented for determining if cerebral blood flow autoregulation functionality has been compromised in a patient. The system includes sensors for detecting and measuring at least two physiological parameters such as oxygenation and blood pressure. The system analyzes these measurements and presents them as waveforms. Episodes of interest in each waveform are determined and compared. Any time lag between the occurrence of episodes of interest in each waveform is established and accounted for. Where there is correspondence between episodes of interest in each waveform then impairment of cerebral blood flow autoregulation is likely.

SYSTEM AND METHOD FOR IDENTIFYING AUTOREGULATION ZONES

A system configured to monitor autoregulation includes a medical sensor configured to be applied to a patient and to generate a regional oxygen saturation signal. The system includes a controller having a processor configured to receive the regional oxygen saturation signal and a blood pressure signal and to determine a cerebral oximetry index (COx) based on the blood pressure signal and the regional oxygen saturation signal. The processor is also configured to apply a data clustering algorithm to cluster COx data points over a range of blood pressures, identify a first cluster of COx data points that corresponds to an intact autoregulation zone for the patient, and provide a first output indicative of the intact autoregulation zone for the patient. 1. A system configured to monitor autoregulation comprising:a medical sensor configured to be applied to a patient and to generate a regional oxygen saturation signal; receive the regional oxygen saturation signal and a blood pressure signal;', 'determine a cerebral oximetry index (COx) based on the blood pressure signal and the regional oxygen saturation signal;', 'apply a data clustering algorithm to cluster COx data points over a range of blood pressures;', 'identify a first cluster of COx data points that corresponds to an intact autoregulation zone for the patient; and', 'provide a first output indicative of the intact autoregulation zone for the patient., 'a controller comprising a processor configured to2. The system of claim 1 , wherein the processor is configured to identify a second cluster of COx data points that corresponds to an impaired autoregulation zone for the patient and to provide a second output indicative of the impaired autoregulation zone for the patient.3. The system of claim 1 , wherein the processor is configured to identify a boundary between the first cluster and a second cluster and to provide a second output indicative of the boundary.4. The system of claim 1 , wherein the processor is ...

System for monitoring cardiovascular and brain function in combination with physiological detection device and method thereof

A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.

SYSTEMS AND METHODS FOR EXTRACTING KEYWORDS IN LANGUAGE LEARNING

Disclosed are systems, methods, and products for language learning that may extract text from various resources having text, using various natural-language processing features, which can be combined with custom-designed learning activities to offer a needs-based, adaptive learning methodology. The system may receive a resource, extract keywords pedagogically valuable to non-native language learning and academic exercises. Metadata describing various aspects of resources from which keywords are extracted may be associated with keywords. Metadata describing various aspects of keywords may also be associated with keywords. Extracted keywords may be stored into a keyword store along with any metadata associated with keywords. 1. A computer-implemented method for extracting keywords from a text comprising:parsing, by a computer, a set of one or more potential keywords from the text of a resource containing text;storing, by the computer, into a keyword store, each potential keyword in the set of the one or more potential keywords matching a term in a computer file containing a keyword whitelist and each potential keyword in the set of the one or more potential keywords matching a collocation in the keyword whitelist;determining, by the computer, for one or more potential keywords in the set of one or more potential keywords, a word frequency score associated with each of the one or more potential keywords with keys of n-grams according to one or more co-occurrence statistics based on one or more scoring rules associated with measuring each of the one or more potential keywords frequency in the text;determining, by the computer, a pedagogical value threshold based upon a proficiency level of a learner and a resource difficulty score of the resource;tagging, by the computer, each potential keyword having a determined word frequency score that satisfies the pedagogical value threshold with a metadata tag indicating the keyword attributes associated with the potential keyword ...

Apparatus and Method for Multivariate Impact Injury Risk and Recovery Monitoring

An apparatus has a housing adapted for mechanical coupling with a skull of a human. A first sensor is positioned in the housing to collect linear motion signals. A second sensor is positioned in the housing to collect rotational motion signals. A processor is positioned in the housing connected to the first sensor and the second sensor. The processor is configured to process the linear motion signals and the rotational motion signals to derive a cumulative impact power measure of repetitive sub-concussive head impacts. The cumulative impact power measure is compared to a threshold indicative of the onset of neural tissue deformations corresponding to physiological changes from repetitive sub-concussive head impacts. An alert is supplied when the cumulative impact power measure is proximate the threshold. 1. An apparatus , comprising:a housing adapted for mechanical coupling with a skull of a human;a first sensor positioned in the housing to collect linear motion signals;a second sensor positioned in the housing to collect rotational motion signals; and process the linear motion signals and the rotational motion signals to derive a cumulative impact power measure of repetitive sub-concussive head impacts,', 'compare the cumulative impact power measure to a threshold indicative of the onset of neural tissue deformations corresponding to physiological changes from repetitive sub-concussive head impacts, and', 'supply an alert when the cumulative impact power measure is proximate the threshold., 'a processor positioned in the housing connected to the first sensor and the second sensor, the processor configured to'}2. The apparatus of wherein the housing has a first chamber for the first sensor claim 1 , the second sensor claim 1 , and the processor claim 1 , a second chamber for a battery claim 1 , and a flexible appendage connecting the first chamber and the second chamber.3. The apparatus of in combination with a collection of adhesive strips to mechanically couple ...

COGNITIVE HEALTH CARE VITAL SIGN DETERMINATION TO NEGATE WHITE COAT HYPERTENSION IMPACT

Embodiments include methods, systems, and computer program products for determining health care vital data. Aspects include receiving a health care vital measurement for a patient and health care vital data for a population. Aspects also include determining a baseline for the patient based at least in part upon the health care vital data for the population. Aspects include determining whether the patient health care vital data deviates from the baseline by more than a threshold and, applying a cognitive learning model to the patient health care vital measurement to correct for an anxiety-based impact to generate a corrected health care vital measurement responsive to a determination that the patient health care vital data deviates from the baseline by more than the threshold. 1. A computer-implemented method for determining health care vital data , the method comprising:receiving, by a processor, a patient health care vital measurement for a patient;receiving, by the processor, health care vital data for a population;determining, by the processor, a baseline for the patient based at least in part upon the health care vital data for the population;determining, by the processor, whether the patient health care vital data deviates from the baseline by more than a threshold;applying a cognitive learning model to the patient health care vital measurement to correct for an anxiety-based impact to generate a corrected health care vital measurement responsive to a determination that the patient health care vital data deviates from the baseline by more than the threshold; andoutputting the corrected health care vital measurement.2. The computer-implemented method of claim 1 , further comprising claim 1 , receiving claim 1 , by the processor claim 1 , a controlled health care vital measurement for the patient responsive to a determination that the patient health care vital data deviates from the baseline by more than the threshold.3. The computer-implemented method of claim 2 ...

SPECTRAL DECOMPOSITION AND DISPLAY OF THREE-DIMENSIONAL ELECTRICAL ACTIVITY IN THE CEREBRAL CORTEX

Systems and methods are provided for measuring electrical activity within a brain of a patient. An electrode array is configured to take measurements of electrical potential as raw electroencephalographic (EEG) data. A data processing component includes a spectral decomposition component configured to divide the raw EEG data into a plurality of frequency intervals, within a total range of frequencies and an inverse solution component configured to transform the raw EEG data associated with each frequency interval into a spatial mapping of electrical activity as to provide a set of parameters, with each parameter representing an average electrical activity at an associated location within the brain over an epoch of interest. 120-. (canceled)21. A method for the analysis of raw electroencephalographic (EEG) data of a subject representing one of a brain event and a brain state comprising:generating the raw EEG data via an electrode array;selecting a period of time representing the one of a brain event and a brain state and an averaging window at a user interface;selecting a first frequency interval from the plurality of frequency intervals; filtering the subset of the raw EEG data to produce a filtered EEG signal representing data within the selected frequency interval;', 'transforming the data represented by the filtered EEG signal over a plurality of frames of EEG data via an inverse solution approximation algorithm as to determine, for the selected frequency interval, respective sets of values at a plurality of locations within a brain of the subject, each value representing a current density within the frequency interval associated with the frequency interval at a corresponding location;', 'averaging the sets of values for each location of the plurality of locations for the selected frequency interval over the selected averaging window within the selected period of time to produce, for each frequency interval, at least one averaged value for each of the plurality ...

APPARATUS AND METHOD FOR MEASUREMENT OF FLOW RATE OF CEREBROSPINAL FLUID IN A CONDUIT

Apparatuses and methods for measurement of flow rate of cerebrospinal fluid in a conduit are provided. The apparatus comprises a heating element mounted on the conduit, the heating element arranged for heating the CSF flowing through the conduit for generating bubbles. The apparatus further comprises two optical sensing devices mounted sequentially on the conduit and downstream from the heating element. The first optical sensing device and the second optical sensing device are separated by a predetermined device interval. Both the first and the second optical sensing devices comprise an optical emitter and an optical detector. The apparatus further comprises a processing device coupled to the optical sensing devices, wherein the signals from the optical sensing devices are transmitted to the processing device for detection of bubbles, resulting in the detection of the flow velocity. The bubble size can be optimized by applying ultrasonic waves or thermal energy. 1. An apparatus for measurement of flow velocity of cerebrospinal fluid in a conduit , comprising:a heating element mounted on the conduit and arranged for heating the cerebrospinal fluid flowing through the conduit to generate bubbles;a first optical sensing device and a second optical sensing device mounted sequentially on the conduit and downstream from the heating element, wherein the first optical sensing device and the second optical sensing device are separated by a predetermined device interval, the first optical sensing device comprising a first optical emitter and a first optical detector and the second optical sensing device comprising a second optical emitter and a second optical detector; anda processing device coupled to the first optical sensing device and the second optical sensing device and wherein the signals from the first optical detector and the second optical detector are transmitted to the processing device for detection of bubbles, the detection of bubbles performed by detecting a ...

SYSTEMS AND SURGICAL TECHNIQUES FOR MONITORING NERVE STATUS

A method for monitoring nerve tissue status during a surgical procedure using a monitoring system that includes a stimulating electrode and a sensing electrode each positioned in proximity to a nerve of a patient. Each electrode may be mono- or bi-polar. A first electrical stimulus is applied by the stimulating electrode and received by the sensing electrode. A monitoring unit determines a first transit time for the first stimulus. A second electrical stimulus is applied by the stimulating electrode and received by the sensing electrode. The monitoring unit determines a second transit time for the second stimulus. The monitoring unit then notifies a user if the second transit time is greater than the first transit time by a predetermined threshold, which may indicate degradation in nerve performance. 1. A method for monitoring nerve tissue status during a surgical procedure using a monitoring system , the monitoring system including a surgical device having a stimulating electrode and a sensing electrode integral thereto , the surgical device configured such that the stimulating electrode and the sensing electrode are electrically isolated from each other through the body of the surgical device , the method comprising:positioning, by an operator, the stimulating electrode and sensing electrode in proximity to a nerve of a patient;applying, by the stimulating electrode, a first electrical stimulus at a first time;receiving, by the sensing electrode, the first electrical stimulus at a second time;determining, by the monitoring unit, a first transit time, based on the first time and the second time;applying, by the stimulating electrode, a second electrical stimulus at a third time to the nerve;receiving, by the sensing electrode, the second electrical stimulus at a fourth time;determining, by the monitoring unit, a second transit time, based on the third time and the fourth time;determining, by the monitoring unit, a difference between the first transit time and the ...

SYSTEMS, METHODS AND DEVICES FOR A SKULL/BRAIN INTERFACE

Methods, devices, and systems induce neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Methods, devices, and systems identify where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces include diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain. 1. A system for facilitating the delivery of a form of neuromodulation to , or the detecting of signals from , one or more target regions of a subject's brain , the system comprising:a transcranial channel configured for transcranial implant and having a transcranial inner lumen adapted to conduct an ionic current to or from a first target region interior of the cranium; anda transparenchymal channel configured for brain implant and to be associated with the transcranial channel, the transparenchymal channel having a transparenchymal inner lumen adapted to conduct the ionic current to or from a second target region interior of the brain.2. The system of claim 1 , wherein the transcranial channel comprises:a transcranial channel proximal end designed to be oriented towards an outer layer of the skull;a transcranial channel distal end designed to be oriented towards the first target region; andan inner wall extending between the transcranial channel proximal end and the transcranial channel distal end and defining the transcranial inner lumen.3. The system of claim 2 , wherein the inner wall is formed of an ion permeable material.4. The system of wherein the transcranial channel further comprises an outer wall formed of a material that is not ion permeable.5. The system of claim 2 , wherein the transcranial ...

Nerve stimulation and monitoring device

There is provided a nerve interface device including (1, 3) comprising: at least one cuff portion; and a first pair of electrodes mounted on the at least one cuff portion. The cuff portion has an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a cuff axis passing through the passageway. The electrodes of the first pair are spaced apart from one another in the direction of the cuff axis.

System and method for ocular function tests

A system for use in performing ocular examinations, such as convergence and accommodation useful in diagnosing traumatic brain injury (including concussion), includes an assessment device. The assessment device includes a portable carrier having a visual target and a distance measurement component. The system may further include a communications channel and a companion device. The distance measurement component communicates via the communication channel with the companion device. The companion device stores one or more distances measured by the distance measurement component.

SYSTEMS AND METHODS FOR NEURO-EEG SYNCHRONIZATION THERAPY

Described are methods, devices, and systems for a novel, inexpensive, easy to use therapy for a number of disorders. Described are methods and devices to treat disorders that involves no medication. Methods and devices described herein use alternating magnetic fields to gently “tune” the brain and affect mood, focus, and cognition of subjects. 2. The device of claim 1 , wherein the controller subunit comprises:a) a motor;b) a power source configurable to power the motor; andc) a rotating element coupled to the motor and the permanent magnets.3. The device of further comprising logic that controls a frequency of rotation of the permanent magnets to be any frequency between about 2 Hz to about 100 Hz claim 1 , in increments of about 0.1 Hz.4. The device of further comprising a third permanent magnet coupled to the controller subunit which is operable to rotate the third permanent magnet about a third axis that is substantially parallel to at least a portion of the concave surface and the third axis different from the axes of the other permanent magnets.5. The device of claim 4 , wherein the controller subunit is operable to rotate the third permanent magnet synchronously with the other permanent magnets.6. The device of claim 4 , wherein the controller subunit is operable to rotate the third permanent magnet out-of-phase with the other permanent magnets.7. The device of claim 3 , where the logic calculates or uploads information of the human subject claim 3 , wherein said information comprises at least one of: (a) an intrinsic frequency within a specified EEG band; and (b) a Q-factor of the intrinsic frequency within the specified EEG band.8. The device of claim 3 , wherein the logic controls the frequency of rotation of the permanent magnets to be:1) lower than the intrinsic frequency of the human subject within a specified EEG band if the intrinsic frequency within the specified EEG band is higher than a target frequency, or2) higher than the intrinsic frequency of ...

METHODS AND SYSTEMS FOR MONITORING INTRABODY TISSUES

A method for monitoring an intrabody region of a patient. The method comprises intercepting electromagnetic (EM) radiation from the intrabody region in a plurality of EM radiation sessions during a period of at least 6 hours, calculating a dielectric related change of the intrabody region by analyzing respective the intercepted EM radiation, detecting a physiological pattern according to said dielectric related change and outputting a notification indicating the physiological pattern. 1. A wearable monitoring device for monitoring an intrabody region during a stress ergometry procedure and/or stress exercise , comprising:at least one probe comprising at least one transducer configured for transmitting to and intercepting electromagnetic (EM) radiation from at least one intrabody region of the lungs of a patient while said patient is performing a stress examination test; calculating a dielectric related change of the at least one intrabody region by analyzing respective said intercepted EM radiation, and', 'detecting a fluid accumulation rate and/or a fluid amount in the lungs during said stress examination test according to said dielectric related change;, 'a processing unit configured foran output unit configured for outputting a notification indicative of said fluid accumulation rate and/or a fluid amount.2. The wearable monitoring device of claim 1 , wherein said detecting includes:estimating an expected signal of intercepted electromagnetic radiation, andmatching said estimated signal to a detected signal of intercepted electromagnetic radiation, thereby detecting said fluid accumulation rate and/or said fluid amount.3204. The wearable monitoring device of claim 1 , wherein said at least one probe () is configured for intercepting said electromagnetic (EM) radiation from a reference intrabody region of said patient;{'b': '201', 'wherein said processing unit () is further configured for calculating a reference dielectric related change in said reference intrabody ...

Automated Data Acquisition, Appraisal and Analysis in Noninvasive Rapid Screening of Neuro-Otologic Conditions Using Combination of Subject's Objective Oculomotor Vestibular and Reaction Time Analytic Variables

An automated data acquisition, appraisal and analysis in noninvasive rapid screening of neuro-otologic condition using combination of subject's objective oculomotor, vestibular and reaction time analytic variables, comprises the steps of: establishing an oculomotor, vestibular and reaction time testing protocol for specific neuro-otologic condition which protocol included eye tracking aspects and which protocol obtains a combination of a subject's objective oculomotor, vestibular and reaction time analytic variables; coupling an eye tracker to subject; automatically establishing a region of interest for the eye tracker in which the region of interest is centered on the subject's pupils; conducting the oculomotor, vestibular and reaction time testing protocol using pre-programmed/automated voice instructions to the subject to obtain a combination of a subject's objective oculomotor, vestibular and reaction time analytic variables; and calculating and displaying a normalized composite test protocol score (0-1) on graphical progressive background. 120.-. (canceled)21. A noninvasive rapid screening of neuro-otologic condition of a subject using combination of a subject's objective oculomotor , vestibular and reaction time analytic variables , comprising the steps of:Establishing an oculomotor, vestibular and reaction time testing protocol for a specific neuro-otologic condition which protocol includes eye tracking aspects and which protocol obtains a combination of a subject's objective oculomotor, vestibular and reaction time analytic variables from a camera based eye tracker capable of capturing and quantifying eye movement velocity data, eye movement latency data, eye movement smoothness data and eye movement precision data;Coupling the camera based eye tracker to the subject;Automatically establishing a region of interest for the camera based eye tracker in which the region of interest is centered on the subject's pupils;Conducting the oculomotor, vestibular and ...

System And Method For Synthesis Of Impedance Matching And Signal Converting Material For All Optical Photo-Acoustic Detection

A system and method is disclosed for non-contact detection and/or imaging and/or monitoring target subsurface tissue of at least one of human or animal anatomy. The system applies a first optical excitation signal to an outer tissue surface at a first location on the anatomy, which excites the target subsurface tissue to produce acoustic signals which are transmitted to an outer tissue surface of the anatomy. A gel-like, impedance matching and signal converting (IMASC) material layer is applied to the outer tissue surface at a second location on the anatomy. The IMASC material layer contains material elements which are able to influence characteristics of an optical signal impinging and reflected from the IMASC material, in accordance with acoustic signals that have been reflected from the target subsurface tissue, and which propagate into the IMASC material. An optical ultrasound detection system is used to process the reflected optical signals reflected from the IMASC material to provide information that may be used to provide an image of the target subsurface tissue. 1. A system for non-contact detection and/or imaging and/or monitoring target subsurface tissue of at least one of human or animal anatomy , the system comprising:an optical excitation signal generating system for generating an optical excitation signal applied to an outer tissue surface at a first location on the anatomy, which excites the target subsurface tissue to produce acoustic signals which are transmitted back to the outer tissue surface of the anatomy;a gel-like, impedance matching and signal converting (IMASC) material which is adapted to be applied to the outer tissue surface at a second location on the anatomy, the IMASC material containing material elements therein which are able to influence characteristics of an optical signal impinging and reflected from the IMASC material, in accordance with acoustic signals that have been reflected from the target subsurface tissue, and which ...

Implantable Devices and Related Methods for Monitoring Properties of Cerebrospinal Fluid

Embodiments of the present disclosure provide an implantable device for monitoring properties of cerebrospinal fluid of a patient. In one embodiment, the device may include a housing, a processor, a support member, one or more sensors, and a data storage. The sensors may be in communication with the processor and configured to detect one or more properties of cerebrospinal fluid. The device may be configured for transmitting the data and receiving instructions by an operator for the delivery of a therapeutic agent or imaging agent from a reservoir disposed within the housing in operable communication with a pump. 1. An implantable device for monitoring properties of cerebrospinal fluid of a patient , the implantable device comprising:a housing configured for attaching to the patient;a processor disposed within the housing;a support member extending from the housing, at least a portion of the support member being configured to move relative to the housing;one or more sensors disposed outside of the housing and attached to the support member, the one or more sensors in operable communication with the processor and configured to detect one or more properties of cerebrospinal fluid; anda data storage disposed within the housing, the data storage in operable communication with the processor and configured to store cerebrospinal fluid data corresponding to the one or more properties.2. The implantable device of claim 1 , wherein the support member comprises a flexible tube configured to bend relative to the housing.3. The implantable device of claim 1 , wherein the support member comprises a flexible wire configured to bend relative to the housing.4. The implantable device of claim 1 , wherein the support member comprises a proximal portion and a distal portion claim 1 , wherein the proximal portion is fixedly attached to the housing claim 1 , and wherein the distal portion is configured to move relative to the housing.5. The implantable device of claim 1 , wherein the ...

Monitoring treatment compliance using speech patterns captured during use of a communication system

Methods and systems for monitoring compliance of a patient with a prescribed treatment regimen are described. Patient speech is detected during use of a communication system such as a mobile telephone and analyzed to determine compliance with a treatment for a brain-related disorder, for example. Speech data representing one or more patient speech pattern and an identity signal containing information used to determine presence/identity of the patient are transmitted from a circuitry-based system at the patient location to a monitoring location. Identity of the patient as user of the communication system is determined through, e.g., biometric or authentication techniques. Speech data is analyzed to determine whether a patient speech pattern matches one or more characteristic speech patterns. Outcome of the analysis is reported to a medical caregiver or other party, for example.

Assessing Neural State from Action Potentials

The neural health or state of a subject is assessed. A recording is obtained of a compound action potential arising in neural tissue of the subject. The recording is processed to determine whether a profile of the recorded compound action potential is anomalous, such as by exhibiting doublets, peak broadening or deformation, or other anomaly. An indication is output regarding the neural state of the subject based on determined anomalies in the recorded compound action potential. 1. A method of assessing a neural state of a subject , the method comprising:obtaining a recording of a compound action potential arising in neural tissue of the subject;processing the recording to determine whether a profile of the recorded compound action potential is anomalous; andoutputting an indication regarding the neural state of the subject based on determined anomalies in the recorded compound action potential.2. The method of wherein the detection of anomalies in the recorded response comprises determining whether more than three peaks exist in the recorded compound action potential.3. The method of wherein the detection of anomalies in the recorded response comprises determining whether a peak in the recorded compound action potential is unexpectedly broad.4. The method of wherein the detection of anomalies in the recorded response comprises determining whether a peak in the recorded compound action potential has an atypically swift rate of rise.5. The method of wherein the detection of anomalies in the recorded response comprises determining whether anomalous frequency components exist in the recorded compound action potential when assessed in the frequency domain.6. The method of wherein the detection of anomalies in the recorded response comprises determining a degree of deviation of the recorded compound action potential from a predefined expected response profile and claim 1 , if the degree of deviation exceeds a predetermined threshold claim 1 , indicating that the recorded ...

Non-Invasive Systems and Methods to Detect Cortical Spreading Depression for the Detection and Assessment of Brain Injury and Concussion

The present invention provides systems and methods for detection and diagnosis of concussion and/or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD/PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD/PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode/amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD/PID on the brain surface. 1. A method of detecting concussion-based cortical spreading depression (CSD) in a subject , the method implemented by one or more processors implementing programming instructions and comprising:receiving from a detection unit comprising a plurality of scalp electrodes configured as a high density electrode array spaced between about 0.5 cm and about 1.5 cm apart from one another, a set of electrical potential signals from a brain area of a patient;determining that values of a first set of the electronic potential signals corresponding to a first portion of the brain area, representing a CSD, are depressed as compared to values of a second set of the electronic potential signals corresponding to a second portion of the brain area, representing normal brain; andgenerating an output in response to the determining step, said output indicating that the patient is experiencing a concussion-based CSD.2. The method of claim 1 , wherein the plurality of scalp electrodes is spaced about 1.0 cm ...

Thermal imaging system

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.

Assessing Neural State from Action Potentials

The neural health or state of a subject is assessed. A recording is obtained of a compound action potential arising in neural tissue of the subject. The recording is processed to determine whether a profile of the recorded compound action potential is anomalous, such as by exhibiting doublets, peak broadening or deformation, or other anomaly. An indication is output regarding the neural state of the subject based on determined anomalies in the recorded compound action potential.

ADJUSTABLE ANGLE NEURO STIMULATION PROBE APAPRATUS

A stimulation probe apparatus as provided herein offers adjustability of a conductive probe tip thereof relative to a handle assembly thereof to which the conductive probe tip is physically attached. The adjustability of the conductive probe tip relative to the handle assembly provide for a surgeon's ability to selectively orientate the conductive probe tip with respect to the handle assembly for enabling a desired placement of the conductive probe tip relative to the handle assembly. In this respect, by allowing a surgeon to selectively control the direction of the conductive probe tip to point in a desired angle, embodiments of the present invention serve clinical needs that help surgeon to perform electrophysiological testing in diverse anatomical structures and in diverse operation procedures. 1. An electrophysiological test stimulation probe apparatus , comprising:a conductive probe tip; anda stimulation probe handle assembly including a main body and a tip adjustment structure attached to the main body, wherein the tip adjustment structure is rotatable with respect to the main body about a longitudinal axis of the main body, wherein the conducting probe is attached to the tip adjustment structure, and wherein the conductive probe tip is pivotable with respect to the tip adjustment structure about a transverse axis that extends one of perpendicular to a longitudinal axis of the stimulation probe handle assembly and skewed with respect to the longitudinal axis.2. The electrophysiological test stimulation probe apparatus of the tip adjustment structure is rotatable with respect to the main body independent of the conducting probe being pivoted with respect to the tip adjustment structure.3. The electrophysiological test stimulation probe apparatus of wherein:the stimulation probe handle assembly includes a stimulation current conveying structure electrically connected to the conductive probe tip; andthe stimulation current conveying structure includes an ...

BRAIN STIMULATION SYSTEM INCLUDING MULTIPLE STIMULATION MODES

A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters. The stimulator delivers test stimulation energy to the brain tissue based on at least one test stimulation parameter and delivers treatment stimulation energy to the brain tissue based on at least one treatment stimulation parameter. One or more treatment stimulator parameters are determined based on the diagnostic data produced by the diagnostic tool The system is constructed and arranged to treat a neurological disease or a neurological disorder. Methods of treating a neurological disease or neurological disorder are also provided. 1. A system for treating a patient , comprising:a stimulator for stimulating brain tissue; anda controller for setting stimulation parameters of the stimulator;wherein the stimulator is configured to operate in a first mode with a first set of stimulation parameters and a second mode with a second set of stimulation parameters different than the first set of stimulation parameters; andwherein the system is configured to treat at least one of a cognitive disease or a cognitive disorder.2. The system according to any claim herein , wherein the cognitive disease or disorder comprises a disease or disorder selected from the group consisting of: Alzheimer's Disease (AD) such as Mild or Moderate Alzheimer's Disease; probable Alzheimer's Disease; a genetic form of Alzheimer's Disease; Mild Cognitive Impairment (MCI); hippocampal damage such as hippocampal damage and/or hippocampal atrophy due to Alzheimer's disease , anoxia , epilepsy , depression; post-traumatic stress disorder (PTSD); traumatic brain injury (TBI); neuronal loss; neuronal damage; chemotherapy induced memory impairment; epilepsy; a seizure disorder; dementia; ...

INSERTION OF MEDICAL DEVICES THROUGH NON-ORTHOGONAL AND ORTHOGONAL TRAJECTORIES WITHIN THE CRANIUM AND METHODS OF USING

An elongated device adapted for insertion, including self-insertion, through the body, especially the skull is disclosed. The device has at least one effector or sensor and is configured to permit implantation of multiple functional components through a single entry site into the skull by directing the components at different angles. The device may be used to provide electrical, magnetic, and other stimulation therapy to a patient's brain. The lengths of the effectors, sensors, and other components may completely traverse skull thickness (at a diagonal angle) to barely protrude through to the brain's cortex. The components may directly contact the brain's cortex, but from there their signals can be directed to targets deeper within the brain. Effector lengths are directly proportional to their battery size and ability to store charge. Therefore, longer angled electrode effectors not limited by skull thickness permit longer-lasting batteries which expand treatment options. 1. A device configured to create an effect on or gather data about a target site in a brain , comprising:at least two shafts configured to be inserted through the skull at an entry site, each of said shafts configured to be inserted at an angle different from all other shafts; andat least one component, including an effector or a sensor, coupled to each of said shafts;wherein a length of each shaft and its associated component is independent of other shafts and their associated components and is not limited to the thickness of the skin, muscle, tissue, bone, or skull at the entry site.2. The device of claim 1 , wherein the at least two shafts comprise three shafts.3. The device of claim 1 , wherein the at least two shafts comprise four shafts.4. The device of claim 1 , wherein each component is housed within its associated shaft.5. The device of claim 1 , wherein each component passes through its associated shaft.6. The device of claim 1 , wherein the at least two shafts are self-tapping or self- ...

SMART INFANT MONITORING SYSTEM AND METHOD

A sleep system including an analysis unit configured to be in data communication with a plurality of sensors, the sensors being selected from one or more sound sensors, biological sensors, environmental sensors, motion sensors, or a combination thereof. 1. An infant analysis system , the system comprising:a plurality of sensors positioned relative to a sleep device to collect data with respect to an infant when positioned within the sleep device and an environment around the infant, wherein the plurality of sensors include a sound sensor and a motion sensor;a sound analysis module configured to analyze the sound data and identify characteristics and patterns of the sound data alone or together with non-sound data, wherein the sound analysis module is configured perform a cry analysis that includes analysis of the sound data corresponding to cries for characteristics to identify nuances and/or emotional factors related to the infant including grunting.2. The system of claim 1 , wherein the cry analysis includes correlation of the sound data corresponding to cries with data collected by the plurality of sensors including motion data claim 1 , vitals data claim 1 , environmental data claim 1 , sleep cycle data claim 1 , wake/sleep data claim 1 , or combination thereof.3. The system of claim 1 , wherein characteristics of the sound data analyzed includes amplitude claim 1 , frequency claim 1 , wavelength claim 1 , duration claim 1 , or combination thereof.4. The system of claim 3 , wherein characteristics of the sound data analyzed includes sound patterns claim 3 , cadence claim 3 , or both.5. The system of claim 3 , wherein the cry analysis starts with a baseline cry to differentiate between cries and grunts.6. The system of claim 1 , wherein the sound analysis module generates a cry algorithm that is personalized to the infant.7. The system of claim 6 , wherein the algorithm is configured to identify values or value ranges in measured characteristics based on previous ...

METHODS AND KITS FOR ASSESSING CENTRAL NERVOUS SYSTEM INTEGRITY

The invention provides methods and kits for detecting, screening, quantifying or localizing the etiology for reduced or impaired cranial nerve function or conduction or associated cranial nucleus or supranuclear input, useful for detecting, diagnosing or screening for increased intracranial pressure, or useful for detecting, diagnosing, monitoring progression of or screening for a disease or condition featuring increased intracranial pressure by tracking eye movement of the subject. The methods may be performed by a) analyzing eye movement of the subject; b) comparing eye movement of the subject to eye movement of a control or the subject's own baseline eye movement; and c) identifying the subject as having eye movement significantly different from the control or the subject's own baseline eye movement. 1. A method for assessing central nervous system integrity comprising:a) Tracking eye movement of the subject;b) Analyzing eye movement of the subject;c) Comparing eye movement of the subject to eye movement of a control or the subject's own baseline eye movement;d) Identifying the subject as having eye movement significantly different from the control or the subject's own baseline eye movement.2. A method for detecting or screening for reduced or impaired cranial nerve function or conduction in a subject comprising:e) Tracking eye movement of the subject;f) Analyzing eye movement of the subject;g) Comparing eye movement of the subject to eye movement of a control or the subject's own baseline eye movement;h) Identifying the subject as having eye movement significantly different from the control or the subject's own baseline eye movement.3. The method of wherein the cranial nerve is selected from the group consisting of II claim 2 , III claim 2 , IV and VI.4. A method according to wherein at least about 100 claim 2 ,000 samples of eye position are obtained.5. A method according to wherein eye movement is tracked in response to a visual stimulus.6. A method according ...

METHODS AND SYSTEMS FOR MONITORING INTRABODY TISSUES

A method for monitoring an intrabody region of a patient. The method comprises intercepting electromagnetic (EM) radiation from the intrabody region in a plurality of EM radiation sessions during a period of at least 6 hours, calculating a dielectric related change of the intrabody region by analyzing respective the intercepted EM radiation, detecting a physiological pattern according to said dielectric related change and outputting a notification indicating the physiological pattern. 1. A wearable monitoring device for monitoring an intrabody region during a stress ergometry procedure and/or stress exercise , comprising:at least one probe comprising at least one transducer configured for transmitting to and intercepting electromagnetic (EM) radiation from at least one intrabody region of the lungs of a patient while said patient is performing a stress examination test; calculating a dielectric related change of the at least one intrabody region by analyzing respective said intercepted EM radiation, and', 'detecting a fluid accumulation rate and/or a fluid amount in the lungs during said stress examination test according to said dielectric related change;, 'a processing unit configured foran output unit configured for outputting a notification indicative of said fluid accumulation rate and/or a fluid amount.2. The wearable monitoring device of claim 1 , wherein said detecting includes:estimating an expected signal of intercepted electromagnetic radiation, andmatching said estimated signal to a detected signal of intercepted electromagnetic radiation, thereby detecting said fluid accumulation rate and/or said fluid amount.3204. The wearable monitoring device of claim 1 , wherein said at least one probe () is configured for intercepting said electromagnetic (EM) radiation from a reference intrabody region of said patient;{'b': '201', 'wherein said processing unit () is further configured for calculating a reference dielectric related change in said reference intrabody ...

AUTOMATED ANALYSIS SYSTEM FOR THE DETECTION AND SCREENING OF NEUROLOGICAL DISORDERS AND DEFECTS

Objects of interest which project beyond the fovea are poorly resolved and lack color information, requiring movement of the eyes in order to obtain a comprehensive image and perception of the surrounding world. Eye movements emanate from different areas of the brain which can be affected by disease and or injury. As such, different neurological disorders will affect a myriad of eye movements in a variety of different ways. An automated system and method, capable of detecting, analyzing and summarizing a person's eye movements is used to detect (diagnose) (either before or after symptoms of said neurological disease are apparent), confirm a prior diagnosis, and/or to monitor the treatment effectiveness for a variety of neurological diseases, neurological movement disorders and potential brain injuries. The analyzed and summarized eye movements are cataloged, interpreted and utilized in a diagnostic matrix in order to highlight and distinguish abnormal eye movements, and to provide an objective clinical or pre-clinical/pre-symptomatic diagnosis based on the non-invasive testing procedures. 1. A computer implemented method for assessing , screening , diagnosing or confirming a diagnosis of one or more neurological diseases , disorders , or injuries , or for monitoring a treatment regimen of said one or more neurological diseases , disorders , or injuries , wherein said one or more neurological diseases , disorders or injuries are selected from the group consisting of small vessel ischemia , multiple system atrophy , progressive supranuclear palsy , cortical basal ganglionic degeneration , drug-induced tremor , and normal pressure hydrocephalus , comprising the steps of:detecting horizontal and vertical positions of one or both eyes of a subject in response to fixed and moving light stimulus using an eye tracking device;determining from data detected in said detecting step using one or more computers or computer networks, one or more values for saccadic measurements ...

METHODS AND SYSTEMS FOR LONG TERM TREATMENT OF NEUROPSYCHIATRIC DISORDERS

Described herein are systems and methods for the automated prediction of relapse of a neurological or psychiatric disorder. The systems and methods may generally use patient data such as patient characteristics, treatment history, clinical history, biometric data, and/or neuroimaging data as inputs to a predictive model. Additionally, the systems and methods may be integrated with a treatment system so that neurostimulation may be automatically delivered when triggered by the predictive model. Systems and methods configured to propose a personalized treatment schedule for maintaining the effects of neurostimulation therapy are also described herein. 1. A system for predicting relapse of a neurological or a psychiatric disorder of a patient comprising:a device configured to obtain one or more data features from the patient; and analyze the one or more data features;', 'generate a mood report based on the analyzed one or more data features;', 'generate a mood plot having a mood threshold predetermined for the patient based on a plurality of mood reports taken over a plurality of neurostimulation treatment sessions; and', 'predict relapse of the neurological or the psychiatric disorder in the patient based on the mood plot., 'a data module, the data module comprising one or more processors configured to run a machine learning algorithm, wherein the machine learning algorithm is configured to2. The system of claim 1 , wherein relapse is predicted if the machine learning algorithm determines that the mood plot does not meet the predetermined mood threshold for the patient.3. The system of claim 1 , wherein the psychological disorder is depression claim 1 , treatment-resistant depression claim 1 , anxiety claim 1 , post-traumatic stress disorder (PTSD) claim 1 , obsessive-compulsive disorder (OCD) claim 1 , a substance use disorder claim 1 , bipolar disorder claim 1 , or schizophrenia.4. The system of claim 1 , wherein the neurological disorder is Parkinson's disease ...

MRI-COMPATIBLE SURGICAL CANNULAE FOR TRANSFERRING A SUBSTANCE TO AND/OR FROM A PATIENT

A cannula for transferring a substance to and/or from a patient includes a tubular support sleeve and a transfer tube. The support sleeve includes a rigid tubular member defining a lumen extending from a proximal end to a distal end of the tubular member. The transfer tube is positioned in the lumen and extends beyond each of the proximal end and the distal end of the tubular member. The tubular member includes a rigid, MRI-compatible material. 1. (canceled)2. A cannula for transferring a substance to and/or from a patient , the cannula comprising:a tubular sleeve having axially opposing first and second end portions and defining a first lumen extending from a proximal end of the first end portion to a distal end of the second end portion; anda transfer tube mounted in the first lumen, wherein the transfer tube defines a second lumen and an exit port, wherein the transfer tube is in direct contact with the tubular sleeve, and wherein the transfer tube and the tubular sleeve slidably cooperate so that at least one is slidably axially extendable and retractable relative to another,wherein the transfer tube is formed of rigid, MRI-compatible fused silica, wherein the second lumen has an inner diameter in a range of 10 μm to 1 mm and the transfer tube has an outer diameter in a range of 75 μm to 1.08 mm, wherein the transfer tube is longer than the tubular sleeve and extends outside the proximal and distal ends of the tubular sleeve, andwherein an exterior surface of the cannula comprises at least first and second co-axially disposed and concentric segments, an outer diameter of the second segment being greater than an outer diameter of the first segment:the first segment is defined by the tubular inner sleeve and extends from a distal end of the tubular inner sleeve to the distal end of the tubular outer sleeve; andthe tubular sleeve defines the second segment, wherein the distal end of the tubular sleeve has an end face that is flat and defines a first step between ...

BRAIN MONITORING SYSTEM

Systems and methods capture light reflected back from a patient's fundus and compares the resulting images to prior images, to determine if the patient is experiencing intraocular inflammation or atrophy. 1. A system useful for FAF and OCT image acquisition of a patient's eye , the system comprising:a broadband LED as an FAF light source;a tunable laser as an OCT light source;a coupler;a first lightpath communicating visible light from the broadband LED, the first lightpath including an excitation filter, the first lightpath communicating light from the excitation filter to the coupler;a second lightpath communicating near infrared light from said tunable laser to said coupler, wherein the coupler combines light from said first and second lightpaths;a single-mode fiber receiving light from said coupler;a splitter receiving light form said single-mode fiber;third and fourth lightpaths receiving light from said splitter;a reference arm in said third lightpath; anda headset sample arm in said fourth lightpath.2. A system according to claim 1 , wherein the broadband LED has a 1060 nm center wavelength and the tunable laser has a 100 kHz sweep rate.3. A system according to claim 1 , wherein the excitation filter operates at 535-585 nm.4. A system according to claim 1 , wherein said combining comprises combining at a 2×1 wavelength division multiplexer coupler and into a single-mode fiber for sequential FAF and OCT imaging.5. A system according to claim 1 , wherein said reference arm comprises a collimator claim 1 , achromatic doublet lens claim 1 , and static silver-coated reference mirror.6. A system according to claim 1 , wherein said splitting and transmitting light is performed via a through-port of a double-cladding fiber coupler.7. A process of FAF and OCT image acquisition of a patient's eye claim 1 , the process comprising:generating light with a broadband LED and tunable laser, wherein visible light from the broadband LED first travels through a lipofuscin ...

SYSTEMS, APPARATUS, AND METHODS FOR USING A WEARABLE DEVICE TO CONFIRM THE IDENTITY OF AN INDIVIDUAL

A wearable device includes at least one sensor for obtaining a unique identifier from the wearer when the wearer and for transmitting the unique identifier to one or more computer processors for use in determining whether the wearer is a particular individual. The wearable device may also include a wireless communications device for transmitting a signal (e.g., to a remote computing device) that confirms the identity of the wearer as the particular individual. A remote computing device, or other device, or individual, may then, based at least in part on receiving the signal, grant wearer access to a computer program, computing system, and/or a particular physical space. 1. A computer-implemented method of providing a particular individual with access to a computer system or computer program , the method comprising:receiving at least one wireless signal from a wearable device, the at least one wireless signal comprising a unique identifier associated with the particular individual;at least partially in response to receiving the at least one wireless signal, comparing the unique identifier with a stored identifier for the particular individual; andat least partially in response to determining that the unique identifier at least partially matches the stored identifier, providing the particular individual with access to the computer system or computer program.2. The computer-implemented method of claim 1 , wherein the method further comprises:transmitting at least one wireless signal to the wearable device requesting an identification signal from the wearable device, wherein receiving the at least one wireless signal from the wearable device is completed after transmitting the at least one wireless signal to the wearable device.3. The computer-implemented method of claim 1 , further comprising providing the wearable device claim 1 , the wearable device comprising:one or more processors;one or more sensors operatively coupled to the one or more sensors; andone or more ...

SYSTEMS AND METHODS FOR SELECTIVE AUTO-RETROPERFUSION ALONG WITH REGIONAL MILD HYPOTHERMIA

Systems and methods for selective auto-retroperfusion along with regional mild hypothermia. In at least one embodiment of a system for providing a retroperfusion therapy to a venous vessel of the present disclosure, the system comprises a catheter for controlling blood perfusion pressure, the catheter comprising a body having a proximal open end, a distal end, a lumen extending between the proximal open end and the distal end, and a plurality of orifices disposed thereon, each of the orifices in fluid communication with the lumen, and at least one expandable balloon, each of the at least one expandable balloons coupled with the body, having an interior that is in fluid communication with the lumen, and adapted to move between an expanded configuration and a deflated configuration, and a flow unit for regulating the flow and pressure of a bodily fluid, and a regional hypothermia system operably coupled to the catheter, the regional hypothermia system operable to reduce and/or regulate a temperature of the bodily fluid flowing therethrough. 1a catheter;a flow unit; anda regional hypothermia system;wherein the regional hypothermia system is operable to regulate a temperature of a bodily fluid flowing therethrough.. A system, comprising: The present application is related to, claims the priority benefit of, and is a U.S. continuation patent application of, U.S. patent application Ser. No. 15/672,064, filed Aug. 8, 2017 and issued as U.S. Pat. No. 10,449,337 on Oct. 22, 2019, which is related to, claims the priority benefit of, and is a U.S. continuation-in-part patent application of, U.S. patent application Ser. No. 13/965,565, filed Aug. 13, 2013 and issued as U.S. Pat. No. 9,724,232 on Aug. 8, 2017, which (a) is related to, and claims the priority benefit of, U.S. Provisional Patent Application Ser. No. 61/682,351, filed Aug. 13, 2012, and (b) is related to, claims the priority benefit of, and is a continuation-in-part application of, U.S. patent application Ser. No. ...