01-11-2018 дата публикации
Номер: US20180311222A1
Принадлежит:
This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders. 2. The compound of claim 1 , wherein the aryl groups or cycle groups have 1-3 heteroatoms claim 1 , wherein the heteroatoms are selected from the group consisting of O claim 1 , N and S.3. The compound of claim 1 , wherein each aryl group or each cycle group is independently substituted with one or more substitution groups selected from the group consisting of F claim 1 , Cl claim 1 , Br claim 1 , CH claim 1 , CHCH claim 1 , CHF claim 1 , CHF claim 1 , CF claim 1 , n-Pr claim 1 , n-Bu claim 1 , i-Bu claim 1 , sec-Bu claim 1 , i-Pr claim 1 , t-Bu claim 1 , CN claim 1 , OH claim 1 , OMe claim 1 , OEt claim 1 , O-iPr claim 1 , OCF claim 1 , methoxycarbonyl claim 1 , methanesulfonyl claim 1 , Ph claim 1 , benzyl claim 1 , formyl claim 1 , and acetyl.6. The compound of claim 1 , wherein Aand Aare connected by a carbon bridge.7. The compound of claim 6 , wherein the bridge comprises —CH— or —CHCH—.8. The compound claim 1 , wherein when the carbon connected to Dis fused with another ring claim 1 , A claim 1 , A claim 1 , A claim 1 , A claim 1 , Aform a ring selected from the group consisting of benzene claim 1 , pyridine claim 1 , pyrimidine claim 1 , furan claim 1 , thiophene and pyridazine.9. The compound of claim 8 , wherein the ring formed by A claim 8 , A claim 8 , A claim 8 , A claim 8 , Ais independently multiply substituted with a member of the group consisting of cyano claim 8 , halogen claim 8 , alkyl claim 8 , branched alkyl claim 8 , halogenated alkyl claim 8 , hydroxyl claim 8 , alkyloxy claim 8 , formyl claim 8 , acetyl claim 8 , amino claim 8 , alkylamino claim 8 , dialkylamino claim 8 , mercaptanyl claim 8 , and alkylmercaptanyl.10. The compound of claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R ...
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