Mit Kohlendioxid aufgeblasener Ballonkatheter zur Radiotherapie

KATHETER

VORRICHTUNG FÜR DIE INTRAVASKULÄRE BEHANDLUNG VON RESTENOSEN

MEDICINE DEVICES FOR THE TREATMENT OF BLOOD VESSELS OF MEANS IONIZATION IRRADIATION

CATHETER

CATHETER WITH CENTRING MEANS

MEDICINE EQUIPMENT FOR THE TREATMENT OF A PART OF A BODY CONTAINER OF MEANS IONIZATION IRRADIATION

Method and apparatus for treating stenosis or other constriction in a bodily conduit

Dilatation/centering catheter used for the treatment of stenosis or other constriction in a bodily passageway and method thereof

CATHETER FOR RADIATION THERAPY

A catheter for radiation therapy comprising: a centering mechanism for irradiating a blood vessel wall with a homogeneous dose; and a perfusion mechanism for perfusing peripheral vessels with blood at all times of centering. The catheter has no roughness on its surface so that it causes neither resistance in moving in the vessel nor a danger of damaging the vessel inner face. In an expandable portion located at the leading end of the catheter, a protrusion is formed in the portion of a specific region at the expanded time by the elasticity difference between two kinds of materials of different elasticities. In the expandable portion, there are arranged a low- elasticity portion and a high-elasticity portion, the latter being expanded more largely than the former to make the protrusion when a pressure is applied. Alternatively, the catheter is given a two-layer structure of inner and outer layers of two kinds of materials of different elasticities, and a cavity is formed in the layer of ...

BRACHYTHERAPY DEVICES AND METHODS FOR THERAPEUTIC RADIATION PROCEDURES

Radiation therapy or brachytherapy devices, systems and methods are in general catheter form and include at least one therapeutic expandable component that assists in placement of radio therapeutic members at desired treatment locations within an existing body cavity or at a site that was formed under a patient's skin for treatment purposes. One or more detectors, such as microdiodes, are present on the device, and a hyperthermia tube or the like is also included that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member.

IRRADIATION CATHETER AND METHOD OF USE

This invention is a catheter (10) for use with a radioactive source (16) within the catheter (10) to irradiate a selected area of a blood vessel in combination with angioplasty procedures, to prevent restenosis of that area of the blood vessel. The catheter (10) has a guidewire channel (18) formed near its distal end to facilitate use of the catheter (10) as a rapid exchange catheter, allowing insertion of the catheter over a guidewire (20) also used in performance of an angioplasty procedure. The catheter (10) can also have a guidewire channel (19) formed near its proximal end to provide O-ring sealing surface and to facilitate free guidewire movement. The catheter (10) also has a closed end (13) to retain the radioactive source (16) within the catheter (10). The catheter (10) can be also be provided with a centering balloon (22) or a set of centering wire loops (50) to center the radioactive source (16) radially within the blood vessel.

PREPARED CATHETER

In the case of a prepared catheter for intraluminal treatment of a vessel sectio n with ionizing radiation, which catheter has an elongate shaft (1) with a proximal end and a distal end (2) as percutaneous transluminal access to the vessel section, an inflatable balloon (8) at the distal end (2) of the shaft (1), an inflation lume n (7) which runs through the shaft (1) and opens into the balloon (8), and a source (1 2) of ionizing radiation which can be positioned in the balloon (8), and which cathete r is filled with an inflation medium (9) for applying pressure to the balloon (8), if the inflation medium (9) is a gas, only a comparatively small proportion of the ioni zing radiation is absorbed and rendered ineffective as it passes through the gas. In this way, the intended dose of radiation can be administered within a short treatment time.

POSITIONING CATHETER FOR INTRAVASCULAR IRRADIATION OF CORONARY AND PERIPHERAL VESSELS WITH RADIOACTIVE RADIATION

The invention relates to a positioning catheter for introducing and positioning an application catheter in a vessel of a patient, wherein the positioning catheter has a distal section which is equipped to receive a distal end of the application catheter and has a structure which effects a spacing between the application catheter introduced into the positioning catheter and the inner wall of the vessel.

Rapid exchange catheter

An over-the-wire rapid-exchange catheter having a distal guidewire channel and a proximal guidewire channel. The catheter is exchanged by withdrawing the catheter from a guiding catheter until the guidewire can be removed from the proximal guidewire channel and then further withdrawn in the conventional fashion. The proximal guidewire channel provides a sealing surface for a releasable seal on the guiding catheter, avoiding the gripping of the guidewire.

Catheter system having tubular radiation source with movable guide wire

A radiation source for inhibiting restenosis including a radiation delivery tube having a radioactive distal region, the tube being adapted to slide over a core wire within a radiation delivery catheter. The core wire is preferably in a slidable relation with the radiation delivery catheter. By withdrawing the core wire to a proximal position, the flexibility of a distal region of the radiation delivery catheter may be increased, thereby allowing the radiation delivery catheter to navigate more tortuous paths and reach more distal sites. Before the radiation delivery tube is advanced into the catheter distal region, the core wire is preferably slid distally to a distal position. With the core wire in the distal position, the core wire may provide a structure that can be used to rapidly advance the radiation source to the lesion site. The core wire may also help constrain lateral movement of the radiation delivery tube and help center the radiation delivery tube within the vessel to provide ...

Intravascular radiation delivery system

An intravascular radiation delivery system including a catheter, a radiation source disposed in an open-ended lumen in the catheter and a closed-ended sheath surrounding the radiation source so as to prevent blood and other fluids from coming into contact with the radiation source. Preferably, the open-ended lumen is centered in the balloon for uniform radiation delivery. The catheter may include a blood perfusion lumen under the balloon or around the balloon. The open-ended lumen in the catheter may have a reduced diameter adjacent the distal end of the catheter to prevent the radiation source from exiting the lumen. Methods of using the radiation delivery system are also disclosed. An alternative method of delivering radiation to a treatment site inside the vasculature of a patient using a gas-filled balloon catheter and a radiation source disposed in the balloon catheter. The treatment site is exposed to radiation, preferably beta radiation, through the gas-filled balloon.

CATHETER

A catheter provided with an elongated tube having channels for the guiding of a radioactive element and for the passage of a guide wire for the catheter as well as fluid under pressure, in which the elongated tube is provided near its distal end on its outer circumference with a recanalization balloon and activatable centering means arranged therein. A by-pass can also be arranged through the recanalization balloon.

ЛУЧЕВАЯ ТЕРАПИЯ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ

FIELD: medicine. SUBSTANCE: method involves delivering treatment member like radiation source through catheter to a selected area in patient hollow organ lumen like in coronary artery for suppressing cicatricial tissue formation in restenosis case after performing balloon plastic operation on blood vessels. One or several treatment members like capsule or granule containing radioactive material are positioned in blood vessel lumen and are movable along the lumen between the proximal and distal end zones under action of liquid flow. Balloon shell is usable for performing plastic repair operation on blood vessels. EFFECT: enhanced effectiveness of treatment; accelerated wound healing. 35 cl, 58 dwg ОДС ПЧ с» (19) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ ВИ” 2 177 350 (51) МПК” (13) С2 А 61 М 5/00 (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 97119603/14, 04.04.1997 (24) Дата начала действия патента: 04.04.1997 (30) Приоритет: 04.04.1996 Ц$ 08/628231 (43) Дата публикации заявки: 27.09.1999 (46) Дата публикации: 27.12.2001 (56) Ссылки: 4$ 5084002 А, 28.01.1992. 4$ 5199939 А, 06.04.1993. КУ 2033212 СЛ, 20.04.1995. (85) Дата перевода заявки РСТ на национальную фазу: 03.12.1997 (86) Заявка РСТ: ($ 97/05538 (04.04.1997) (87) Публикация РСТ: М/О 97/371715 (16.10.1997) (98) Адрес для переписки: 117279, Москва, ул. Миклухо-Маклая 55А, АООТ "ЦПУ", Е.А. Харченко (71) Заявитель: . НОВОСТЕ КОРПОРЕИШН (05$), ЭМОРИ УНИВЕРСИТИ (1$) (72) Изобретатель: УАКСМАН Рон (ЦЗ), УЕЛДОН Томас Д. (4$), МЕЛОУЛ Рафейел Ф. (0$), ХИЛСТЕД Ричард А. (4$), РОЗЕН Джонатан Дж. (4$), БОННОИТ Джордж К. (0$) , ХОЛПЕРН Дейвид С. (4$), ЛАРСЕН Чарлз 3. (4$), КРОККЕР Иан Р. (4$) (73) Патентообладатель: . НОВОСТЕ КОРПОРЕИШН (1$), ЭМОРИ УНИВЕРСИТИ (0$) (74) Патентный поверенный: Харченко Елена Алексеевна (54) ЛУЧЕВАЯ ТЕРАПИЯ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ (57) Изобретение относится к медицине. Представлены устройство и способ для доставки лечебного элемента, такого как источник ...

IMPROVED IRRADIATION CATHETER AND METHOD OF USE

The invention is a catheter (10) for use with a radioactive source (16) within the catheter (10) to irradiate a selected area of a blood vessel in combination with angioplasty procedures, to prevent restenosis of that area of the vessel. The catheter (10) has a guidewire channel (18) formed near its distal end to facilitate use of the cather (10) as a rapid exchange catheter, allowing insertion of the catheter (10) over a guidewire (20). The catheter (10) has a radiation lumen (14) with a sealed end to retain the radioactive source (16) within the catheter (10). The radiation lumen (14) is sufficiently longer than the guidewire channel (18), keeping the radiation source (16) segregated from the blood, allowing the use of a non-sterile radiation source. The catheter (10) can be provided with a balloon (22) or a set of wire loops (50) to center the radioactive source (16) radially within the blood vessel.

INTRACAVITARY CATHETER FOR USE IN THERAPEUTIC RADIATION PROCEDURES

The present invention is for radiation diagnosis and/or therapy in or near body cavities accessible through existing orifices. At least one balloon of a catheter and balloon assembly is inflated by fluid communication through the catheter. Several embodiments provide for diagnostic procedures or radiation therapy, at times in association with one or more of formation of seals, control of movement, nutrient passage and drainage. When radiation therapy is provided, rods or other radiotherapeutic items are secured, positioned or inserted along the contour of the surface of the balloon and are thus deployed to treatment position by balloon inflation.

RADIATION TREATMENT OF THE VASCULAR SYSTEM

Apparatus for delivery of a treatment element (22) such as a radiation source, through a catheter (92) to a desired site in the interluminal passageways of a patient, such as the coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. One or more treatment elements (22), such as a capsule or pellet containing radioactive material, is positionable within the lumen (144) and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. Balloon membrane (256) can be used for angioplasty.

DEVICE FOR LOADING AND CENTERING OF A VASCULAR RADIATION THERAPY SOURCE

An intravascular catheter having an expandable inflation region adapted for centering a radiation dose in a body lumen for a period of time sufficient to permit delivery of a radiation dose to the body lumen. The catheter includes a delivery lumen, and a blind internal lumen for receiving a wire having a radiation source located at the distal end of the wire. The blind internal lumen is received in the delivery lumen of the catheter. The blind internal lumen prevents contamination of the radiation source by fluids from the body lumen. The radiation source is advanced through the blind internal lumen towards the inflation region of the catheter. The inflation region includes a plurality of balloon lobes at the distal end of the catheter. The plurality of balloon lobes,when inflated, can center the radiation source within a curved section of the body lumen.

DILATATION/CENTERING CATHETER

An apparatus and method for treating an occlusion or constriction, such as a stenosis in a blood vessel or other conduit in the body, as well as an apparatus and method for treating a tumor or cancerous area occurring around a conduit or duct in the body. The apparatus includes a catheter provided with a centering balloon including a catheter centering balloon encircling a portion of the catheter near its distal end. This centering balloon contains a plurality of thin spoke-like members. A second dilatation balloon attached to the surface of the catheter is used to treat the stenosed area. A radioactive source of material is included for treating the stenosis or cancer.

CATHETER AND GUIDE WIRE ASSEMBLY FOR DELIVERY OF A RADIATION SOURCE

A guide wire (25, 80) for use in intravascular procedures having a proximal hollow portion (26,92) and a solid distal portion (30). The hollow portion (26,9 2) is adapted to receive a radioactive source material (51) for irradiating a body lum en (34) to reduce the likelihood of the development of restenosis.

PERFUSION BALLOON AND RADIOACTIVE WIRE DELIVERY SYSTEM

This invention is a catheter (320) capable of irradiating blood vessel walls to inhibit restenosis after angioplasty. Catheters (320) are capable of simultaneous irradiation, angioplasty, and in some devices drug infusion. Preferred catheters (320) include a helical perfusion balloon (336) having strand windings (346) spaced apart when inflated, and defining a perfusion lumen (356) within. A tubular sheath (374) over the helical strands (346), and distal shaft region (326) is used in some embodiments and defines an outer wall for the perfusion lumen (356). A spiral, inter-strand space (376) is defined between the sheath outer wall, and the blood vessel inner wall providing a confined volume for controlled delivery of drugs to the vessel wall in conjunction with irradiation. A device having a radiation wire distally closed end tube is provided. A device having a radiation wire open ended tube terminating proximally of the perfusion lumen is also provided.

CATHETER WITH STAND-OFF STRUCTURE

A catheter (10), and a method for performing radiation treatment at a site where angio-plasty was performed, are disclosed. The catheter (10) includes a hollow, cylindrical member (12) constructed from a fairly flexible material. The catheter is maneuvered within the body by traveling over a guide wire which was initially maneuvered in the blood vessel to a position beyond the actual site of a stenosis. Stand-off structure (26) having a stand-off balloon (28) surrounds a portion (30) of the outer surface of the catheter (10). The distal end (18) of the catheter (10) includes an inner lumen plug (38), and a distal mandrel (40) extending through the inner lumen plug (38). The distal mandrel (40) is manufactured from shape memory alloy to stiffen, and reinforce the catheter when the catheter is introduced within the blood vessel.

DEVICE FOR DILATING AND IRRADIATING A VASCULAR SEGMENT OR BODY PASSAGEWAY

The present invention is directed to a device for dilating and irradiating a vascular segment, body passageway or an obstruction in a vascular segment or body passageway. The device comprises electroless deposition, electro-deposition or ion implantation of a radioactive coating on an expansion member. The radioactive coating may be deposited such that it has a total radioactivity that varies in at least one dimension of the expansion member. The expansion member may be substantially cylindrical and/or an expandable mesh. The radioactive expansion member, which is moveable between a radially contracted configuration and a radially expanded configuration, is radially contracted and placed into a vascular segment or body passageway. After advancing the contracted expansion member to a predetermined site in the vascular segment or body passageway, the expansion member is radially expanded to dilate and irradiate the predetermined site, while allowing fluid to flow through the expansion member ...

RADIATION CATHETER WITH MULTILAYERED BALLOON

The disclosure is directed to catheter devices and methods for controlled application of irradiation to tissue adjacent a body site, such as cavity after removal of tissue, e.g. cancer. The catheter device includes an inflatable balloon having at least two layers. The inflatable balloon has an expansion of more than 25% and less than 200% when inflated from the un-inflated condition to a turgid condition, preferably more than 50% and less than 150%. In the turgid condition the polymeric material(s) of the balloon layers are at or near the elastic limit of the balloon layer material. The balloon may contain or be formed of or be coated with radiopaque material to facilitate positional or symmetry verification.

COMBINATION IONIZING RADIATION AND RADIOSENSITIZER OR IMMUNOMODULATOR DELIVERY DEVICES AND METHODS FOR INHIBITING HYPERPLASIA

The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled radiosensitizer or immunomodulator delivery in combination with ionizing radiation to selected locations within a patient′s vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment (10), the proximal end (14) and distal end (16), an ionizing radiation source (22) coupleable to the catheter body (12) for applying radiation doses to a body lumen (32),and means coupleable to the catheter body (12) or the radiation source (22) for releasing a radiosensitizer or immunomodulator to the body lumen (32).

CATHETER FOR RADIATION THERAPY

A catheter for radiation therapy comprising: a centering mechanism for irradiating a blood vessel wall with a homogeneous dose; and a perfusion mechanism for perfusing peripheral vessels with blood at all times of centering. The catheter has no roughness on its surface so that it causes neither resistance in moving in the vessel nor a danger of damaging the vessel inner face. In an expandable portion located at the leading end of the catheter, a protrusion is formed in the portion of a specific region at the expanded time by the elasticity difference between two kinds of materials of different elasticities. In the expandable portion, there are arranged a low-elasticity portion and a high-elasticity portion, the latter being expanded more largely than the former to make the protrusion when a pressure is applied. Alternatively, the catheter is given a two-layer structure of inner and outer layers of two kinds of materials of different elasticities, and a cavity is formed in the layer of the ...

Brachytherapy catheter with twisted lumens and methods of use

An over-the-wire catheter provides substantially shadow-free delivery of radiation to a body lumen by having a treatment region wherein a guidewire tube and a radiation source tube form a parallel double helix configuration. When a radiation source is inserted into the radiation source tube and a guidewire is present in the guidewire tube, no portion of the treatment site will be obscured from all radiation emitted by the radiation source because, within the treatment region, the guidewire and the radiation source are not in a conventional, axially parallel configuration. Optionally, a balloon may be mounted about or adjacent the treatment region of the catheter, the balloon providing centering and/or dilatation functions.

BRACHYTHERAPY DEVICE ASSEMBLY AND METHOD OF USE

A temporarily implantable brachyherapy assembly is adapted to locally deliver acute doses of radiation to tissue at or adjacent to a body lumen wall. The assembly includes a radiation source which is stored in a housing in radioactive isolation. A first delivery member is adapted to removably engage the radiation source and remove it from storage for delivery to an injured or stenosed region of a vessel. The first delivery member is adapted to be delivered to the site through a lumen extending through a second delivery member. The second delivery member is also a shielding device with a shielded region of substantially radiopaque material, and also with an unshielded region made of substantially radioluscent material and which is distal to the shielded region. A third delivery member or centering device has a lumen through which the second delivery member may be delivered to the treatment site. A centering member on the centering device includes an expandable member that expands to circumferentially ...

Brachytherapy for arrhythmias

An apparatus and method for brachytherapy. One method includes locating a region of cardiac tissue having a relatively large probability of originating or transmitting electrical signals which result in arrhythmic activity and irradiating the region of cardiac tissue to reduce the amount of arrhythmic activity. Irradiating can include regulating protein expression of myocardial cells, killing myocardial cells, ablating myocardial cells, irradiating sleeves of atrial muscle that extend from a left atrial wall around the pulmonary veins, and/or creating lesions that block electrical conduction through myocardial tissue. Locating the region can include locating a foci of an atrial arrhythmia or locating the foci adjacent a pulmonary vein.

Rectal Catheter for Urological & Other Applications

According to one general aspect, there is A medical device comprising a locking mechanism that is used to connect a plurality of catheters, a multi-balloon inflator that inflates multiple balloons on a single catheter, a extraction point used to remove human fluids from the human body, and a connecting point that allows a syringe or a machine to insert liquid saline solution or radioactive isotopes into said multi-balloon inflator.

DUAL DOUBLE BALLOON CATHETER

A dual double balloon catheter includes a catheter having a proximal end portion, a central portion and a distal end portion, and a secondary treatment balloon for a catheter. The catheter includes a plurality of lumens within the catheter extending from the proximal end portion, a plurality of inflatable balloons positioned in the central portion and a secondary treatment balloon communicatively associated with the distal end portion of the catheter, and the balloons and the secondary treatment balloon being communicatively connected with a corresponding one of the plurality of lumens to selectively inflate/deflate the corresponding inflatable balloon or to receive a radioactive dose or a therapeutic agent for a treatment. 1. A dual double balloon catheter , comprising:a catheter having a proximal end portion, a central portion and a distal end portion;a plurality of lumens positioned in association with the catheter extending from the proximal end portion of the catheter;a plurality of inflatable balloons positioned in association with the central portion of the catheter, the plurality of inflatable balloons being in communication with respective ones of the plurality of lumens to enable filling the plurality of inflatable balloons with an inflation medium to enable selectively inflating and deflating one or more of the plurality of inflatable balloons independently of at least one other of the plurality of inflatable balloons to selectively one or more of position or stabilize the catheter in a cavity for a treatment, one or more of the plurality of inflatable balloons including at least one of other of the plurality of lumens configured to respectively receive a treatment medium or a contrast medium for a treatment, each of the plurality of inflatable balloons being configured to be positioned spaced from each other in a longitudinal direction along the length of the catheter; anda secondary treatment balloon communicatively associated with the distal end ...

RADIATION CATHETER WITH MULTILAYERED BALLOON

Medical appliances for the treatment of blood vessels by means of ionizing radiation

АСИММЕТРИЧНОЕ ОБЛУЧЕНИЕ ПОЛОСТИ ТЕЛА

1. Устройство для лечения ткани, окружающей полость в теле пациента, включающее: !a. дистальную часть, сформированную для развертывания внутри полости тела; ! b. участок лечения на дистальной части, сформированный для асимметричного развертывания внутри полости тела так, чтобы быть ближе к первой части ткани, окружающей полость, чем к противоположной, второй части ткани, окружающей полость; и ! c. источник радиации на участке лечения, облучающий первую часть ткани, окружающей полость тела, более интенсивно, чем противоположную вторую часть ткани полости тела. ! 2. Устройство по п.1, в котором участок лечения сформирован для расположения, по крайней мере, на 1 мм ближе к первой части ткани, окружающей полость, чем ко второй части ткани, окружающей полость. ! 3. Устройство по п.1, в котором участок лечения сформирован для расположения, по крайней мере, на 2 мм ближе к первой части ткани, окружающей полость, чем ко второй части ткани, окружающей полость. ! 4. Устройство по п.1, в котором участок лечения сформирован для расположения, по крайней мере, на 10 мм ближе к первой части ткани, окружающей полость, чем ко второй части ткани, окружающей полость. ! 5. Устройство по п.1, в котором дистальная часть имеет трубчатую структуру с первой полостью, проходящей в ней, сформированной для приема источника радиации. ! 6. Устройство по п.5, в котором трубчатая структура смещена или способна смещаться от продольной оси устройства так, чтобы первая полость могла асимметрично развертываться внутри полости тела. !7. Устройство по п.5, в котором трубчатая структура из дистальной части отклоняется по направлению к первой части ткани, окружающей полость,

Arzneigerät für die Behandlung eines Teiles eines Körpergefässes mittels Ionisierungsbestrahlung

Applikator für die intraoperative Strahlentherapie

Die Erfindung betrifft einen Applikator (1) für die intraoperative Strahlentherapie mit niederenergetischer Röntgenstrahlung, umfassend einen Applikatorkörper (5), eine Außenoberfläche (4) mit einer Umfangsaußenfläche und einem distalen Ende (3), eine Aufnahmevorrichtung (8) an einem proximalen Ende (2), mit der der Applikator (1) an einer Röntgenbestrahlungsvorrichtung (20) befestigbar ist, und eine innere Aussparung (9) mit einer Öffnung an dem proximalen Ende (2), in die eine Röntgenstrahlungsquelle (30, 31) einführbar ist. Der Applikator (1) weist an seiner Außenoberfläche (4) eine feste poröse Struktur auf. Die feste poröse Struktur bildet eine luftdurchlässige zusammenhängende Kanalstruktur, die luftleitend mit dem proximalen Ende (2) des Applikators (1) verbunden ist.

Vorrichtung zum Durchführen und Überwachen der endovaskulären Brachytherapie

Vorrichtung zur Durchführung der endovaskulären Brachytherapie, bei der im Bereich einer Katheterspitze ein Beta- oder Gamma-Strahler, zur Verhinderung von Restenosen nach einer Entfernung von Plaques an Gefäßwänden, radioaktive Strahlung zur Unterdrückung des konstruktiven Gefäßumbaus abstrahlt, mit gleichzeitiger OCT-Überwachung, wobei ein Brachytherapie-Katheter mit einem OCT-Katheter zur einer integrierten Einheit kombiniert ist.

Strahlenbehandlungsgerät für Blutgefä e

Ballonkatheter zur Zentrierung

WITH CARBON DIOXIDE OF BLOWING UP BALLOON CATHETERS TO THE RADIO THERAPY

Catheter and guide wire assembly for delivery of a radiation source

X-ray catheter

A radioisotope delivery device

Medical appliance for the treatment of a portion of the body vessel by ionizing radiation

Radiation treatment of the vascular system

Device for treating constriction in a bodily conduit

IMPROVED IRRADIATION CATHETER AND METHOD OF USE

The invention is a catheter (10) for use with a radioactive source (16) within the catheter (10) to irradiate a selected area of a blood vessel in combination with angioplasty procedures, to prevent restenosis of that area of the vessel. The catheter (10) has a guidewire channel (18) formed near its distal end to facilitate use of the cather (10) as a rapid exchange catheter, allowing insertion of the catheter (10) over a guidewire (20). The catheter (10) has a radiation lumen (14) with a sealed end to retain the radioactive source (16) within the catheter (10). The radiation lumen (14) is sufficiently longer than the guidewire channel (18), keeping the radiation source (16) segregated from the blood, allowing the use of a non-sterile radiation source. The catheter (10) can be provided with a balloon (22) or a set of wire loops (50) to center the radioactive source (16) radially within the blood vessel.

BRACHYTHERAPY DEVICES AND METHODS FOR THERAPEUTIC RADIATION PROCEDURES

Radiation therapy or brachytherapy devices, systems and methods are in general catheter form and include at least one therapeutic expandable component that assists in placement of radio therapeutic members at desired treatment locations within an existing body cavity or at a site that was formed under a patient's skin for treatment purposes. One or more detectors, such as microdiodes, are present on the device, and a hyperthermia tube or the like is also included that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member.

DEVICE FOR THE INTRAVASCULAR TREATMENT OF RESTENOSES

Perfusion balloon and radioactive wire delivery system

A catheter capable of irradiating blood vessel walls to inhibit restenosis after angioplasty. Catheters are capable of simultaneous irradiation, angioplasty, and in some devices, drug infusion. Preferred catheters include a helical perfusion balloon having strand windings spaced apart when inflated and defining a perfusion lumen within. A tubular sheath over the helical strands and distal shaft region is used in some embodiments and defines an outer wall for the perfusion lumen. A spiral, inter-strand space is defined between the sheath outer wall and the blood vessel inner wall, providing a confined volume for controlled delivery of drugs to the vessel wall in conjunction with irradiation. A device having a radiation wire, distally closed-end tube is provided. A device having a radiation wire open ended tube terminating proximally of the perfusion lumen is also provided.

Radioactive substance administrator

A radioactive substance administrator including a syringe structured to receive a dosage of the radioactive substance therein; a containment housing structured to contain the syringe and including a radioactivity retardant material, structured to substantially attenuate the emergence of radioactivity through the containment housing, and a plunger track structured to contain a plunger assembly of the syringe movably therein; an exterior actuation assembly operatively associated with the containment housing and structured to actuate the plunger assembly of the syringe; and a secondary shielding assembly operatively associated with an outlet of the containment housing and structured to permit the passage of the radioactive substance to the patient while also attenuating radioactivity emerging from the outlet of the containment housing and radioactivity emanating from the radioactive substance exiting the containment housing.

Radiation catheter with multilayered balloon

A catheter device for irradiating tissue surrounding a body site within a body of a patient, includes an elongated shaft which has a distal portion configured to be deployed within the body site. A treatment location at the distal portion has one or more radiation guides configured to receive a radiation source to irradiate tissue at least in part surrounding the body site. An inflatable multilayered balloon is located to surround the treatment location with a wall thereof having at least two layers including a first layer separate from, inside, and in contact with a second layer around an entire periphery of the first layer, and each of the first layer and the second layer being secured to the distal portion of the elongated shaft.

Self-expanding medical device

APPARATUS FOR CARRYING OUT AND MONITORING INTRAVASCULAR BRACHYTHERAPY

PROBLEM TO BE SOLVED: To carry out intravascular brachytherapy while avoiding the exchange of various catheters and monitoring OCT (optical coherence tomography) simultaneously. SOLUTION: In an apparatus for carrying out and monitoring intravascular brachytherapy, a β-ray or γ-ray radiator radiates radiation for the suppression of structural blood vessel change to prevent restinosis after elimination of plaque in a blood vessel wall, in a tip range of a catheter, and monitoring by optical coherence tomography (OCT) is performed at the same time, wherein a catheter for brachytherapy is built into one unit together with an OCT catheter. COPYRIGHT: (C)2005,JPO&NCIPI ...

VORRICHTUNG FÜR DIE INTRAVASKULÄRE BEHANDLUNG VON RESTENOSEN

CATHETER WITH SAFETY MARGIN STRUCTURE

DEVICE FOR THE INTRAVASKULÄRE TREATMENT OF RESTENOSEN

RADIATION TREATMENT EQUIPMENT FOR BLUTGEFÄ E

Medical appliance for the treatment of a portion of the body vessel by ionizing radiation

MAGNETIC GUIDE WIRE AND CATHETER

A self-centering or alignment system for catheter or other medical treatment devices. The system includes magnets (120, 130) on interacting elongate devices (100-1, 116-1) to separate and align the elongate devices (100-1, 11 6- 1) for use. The interactive elongate devices can include a guide catheter (1 16- 1) and treatment catheter (100-1) or a treatment catheter and guide wire. Th e system of the present invention facilitates insertion and placement of medic al devices at a treatment site and provides enhanced maneuverability and insertability for treatment devices.

Medical Appliances for the Treatment of Blood Vessels by Means of Ionizing Radiation

MINIMALLY INVASIVE MEDICAL DEVICE FOR PROVIDING A RADIATION TREATMENT

A minimally invasive intravascular medical device for providing a radiation treatment in a body passageway such as a coronary vessel of the vascular system. The device includes a flexible elongated member having distal and proximal portions. The distal portion is percutaneously insertable into a vessel and includes a distal end that is directable through the vessel to the treatment site. A radiation source is attached about the distal portion for delivering a radiation treatment to the walls a vessel having a stent positioned thereagainst. The distal portion of the elongated member includes a wire coil positioned about the tapered distal end of a mandril wire. The combination of the wire coil and the tapered distal end of the mandril wire provides variable flexibility to the distal portion of the device. The distal portion also has a predetermined curvature for directing the distal end of the device through the vessel. A safety wire is also extendable through the passageway of the wire coil to provide further flexibility to the distal portion. The radiation source is fixedly positioned about either the tapered distal end of the mandril wire or the safety wire in the passageway of the wire coil. An annular recess is included about the tapered distal end of the mandril wire to fixedly position a source of radioactive material therein.

MEDICAL APPLIANCE FOR THE TREATMENT OF A PORTION OF BODY VESSEL BY IONIZING RADIATION

A balloon catheter comprises a catheter tube 1 surrounded distally by an elongated inflatable balloon 2. Throughout the catheter tube 1 is a longitudinal lumen 3 for positioning a radioactive radiation emitter 5 within the balloon. The catheter comprises a second lumen 4 for directing inflation fluid into the balloon 2. Belt means 7 creating a waist are mounted on the balloon 2 to squeeze it down to nearly the diameter of the catheter 1 thereby leaving a small passge 8 for the inflation fluid. The belt means 7 divide the balloon into sections to assure a close center fit of the catheter 1 within the balloon.

CENTERING BALLOON CATHETER

In accordance with the present invention, there is provided a catheter for inser tion into a vessel of a patient. The catheter has distal and proximal ends and is made from an elongated flexible shaft also having distal and proximal ends. The shaft has a central lumen extend ing therethrough which is substantially centered within the shaft. The shaft also having distal a nd proximal ends and further includes an inflation lumen. The catheter includes an inflatable, prefer ably non-compliant, outer balloon disposed at its distal end and an inflatable, preferably compliant , inner balloon disposed within the outer balloon. The inner balloon is in fluid communication w ith the inflation lumen for inflation and deflation thereof. The central lumen extends through the inner balloon. The inner balloon is a centering balloon, whereby when it is at least partially infl ated the distal end of said central lumen is substantially centered within the vessel.

CATHETER SYSTEM HAVING TUBULAR RADIATION SOURCE

A radiation source for inhibiting restenosis including a radiation delivery tube (20) having a radioactive distal region (24), the tube (20) being adapted to slide over a guide wire (28) within a radiation delivery catheter (42). In use, the catheter (42) is advanced to a site to be treated, the balloon (54) inflated, and the radioactive tube (20) advanced over the radiation source guide wire (28) within the lumen (50).

ENERGY FILTERING SYSTEM

An energy filtering system (42) including an energy filtering material (42) provided between a radioactive material (20) and a treatment target (10) such that radioactive energy is filtered.

LIGHT GENERATING DEVICE TO INTRAVASCULAR USE

Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

CATHETER ASSEMBLY FOR CENTERING A RADIATION SOURCE WITHIN A BODY LUMEN

The invention is directed to a catheter assembly with blood perfusion capability suitable for maintaining patency of a body lumen for a period of time sufficient to allow delivery of a radiation source to the body lumen. The catheter assembly includes an inner tubular member which extends coaxially within an outer tubular member, with the distal ends of the inner and outer tubular members being joined together. The catheter includes an expandable region which maintains and centers a radiation source within the body lumen while not inhibiting blood to perfuse around and past the expandable region. In one embodiment, the expandable region includes a plurality of outwardly extendible strap-like members which are formed on the outer tubular member of the elongated catheter body. A plurality of the strap-like members can be spaced in a staggered arrangement along the outer tubular member so that when moved to an expanded position, the strap-like members center the radiation source wire within ...

MULTI-LUMEN FLUTED BALLOON RADIATION CENTERING CATHETER

A multi-lumen balloon (10) for use in a flutes balloon centering catheter (1) and method for providing the same. The multi-lumen balloon maintains a radiation source (25) at the center of a cardiovascular artery, has improved blood perfusion capability, and has improved balloon refolding characteristics. The method of fabricating a multi-lumen balloon designed for a radiation centering uses an improved extrusion process that allows the manufacture of the multi-lumen balloon sub-assembly to be done separately from the catheter shaft assembly.

MULTITUBE ESOPHAGEAL BRACHYTHERAPY CATHETER

A system for delivery of radiation to a target portion of a native tissue is provided. The system includes a catheter having a catheter body with a proximal portion, a distal portion, and a longitudinally oriented lumen therebetween. The system further includes an expansion device disposed about at least a portion of the catheter body and having an expanded configuration and a non-expanded configuration. The system also includes a plurality of tubes disposed about at least a portion of the expansion device. Each of the plurality of tubes is configured to selectively guide exposure of a radiation source to the target portion of the native tissue. 1. A system for delivery of radiation to a target portion of a native tissue , the system comprising:a catheter comprising a catheter body having a proximal portion, a distal portion, and a longitudinally oriented lumen therebetween;an expansion device disposed about at least a portion of the catheter body and having an expanded configuration and a non-expanded configuration; anda plurality of tubes disposed about at least a portion of the expansion device, each of the plurality of tubes being configured to selectively guide exposure of a radiation source to the target portion of the native tissue.2. The system of claim 1 , wherein the distal portion of the catheter body comprises a tapered tip having a closed distal end.3. The system of claim 1 , wherein the distal portion of the catheter body comprises a tapered tip having a distal opening longitudinally aligned and in fluid communication with the longitudinally oriented lumen of the catheter body.4. The system of claim 2 , wherein the longitudinally oriented lumen has a longitudinal axis and the distal portion of the catheter body defines a lateral port non-concentric with the longitudinal axis.5. The system of claim 2 , further comprising an anchor balloon disposed about the distal portion of the catheter body proximal to the tapered tip claim 2 , the anchor balloon ...

Perfusion balloon and radioactive wire delivery system

A catheter capable of irradiating blood vessel walls to inhibit restenosis after angioplasty. Catheters are capable of simultaneous irradiation and angioplasty. Preferred catheters include a helical perfusion balloon having closely spaced or contacting adjacent windings when inflated. A helical balloon with strand windings having little space therebetween decreases the amount of blood between the balloon exterior surface and vessel walls. A removable, sheathed, elongate radiation source is used with some embodiments. A fixed, flexible sheath partitioning the catheter lumen into sterile and non-sterile portions is included in another embodiment. Internal rather than external perfusion and use of gas to inflate the balloon decrease the absorption of beta radiation by blood, and liquid inflation fluid, respectively.

Centering balloon catheter

CATHETER FOR USE IN VESSEL

PROBLEM TO BE SOLVED: To enhance the push-forward and pursuing characteristics and preclude a radiations source from touching humor by accommodating the radiations source in a blind rumen, and installing a reinforcing mandrel in the body of a catheter. SOLUTION: In the body 11 of a catheter, a blind rumen 19 is installed by extending from the nearest end to around the farthest end of an inflated balloon 12. The blind rumen 19 is sealed so that no humor intrides and the farthest end 20 is closed, and a bacteria-free bulkhead is formed between a wire and the lymph system of the patient. A mandrel 21 is installed in the blind rumen 19, and thereby the push-forward characteristic and strength of the catheter assembly are enhanced. A small sphere 22 is formed at the tip of the mandrel 21 so that it is prevented from sticking into the farthest end of the rumen 19. The wire of a radiations source is inserted in the rumen 19 to prevent touching the humor, and good serviceability is provided for ...

ОБЛУЧАЮЩИЙ КАТЕТЕР С МНОГОСЛОЙНЫМ БАЛЛОНОМ

1. Катетерное устройство для облучения ткани, окружающей место в теле пациента, содержащее удлиненный стержень, который содержит дистальную часть, выполненную с возможностью размещения в указанном месте тела, и имеет центральную продольную ось; участок лечебного воздействия, расположенный на указанной дистальной части и содержащий источник излучения или выполненный с возможностью приема источника излучения для облучения ткани, по меньшей мере, частично окружающей указанное место тела; и надувной баллон, окружающий участок лечебного воздействия, со стенкой, содержащей по меньшей мере два слоя полимерного материала, причем, когда надувной баллон надут до раздутого состояния, полимерный материал по меньшей мере одного слоя надувного баллона находится на пределе упругости материала или около предела упругости. ! 2. Устройство по п.1, в котором надувной баллон имеет заранее заданный размер и форму, когда находится в раздутом состоянии. ! 3. Устройство по п.1, в котором надувной баллон имеет увеличение объема меньше чем на 200%, когда находится в раздутом состоянии. ! 4. Устройство по п.1, в котором надувной баллон имеет увеличение объема меньше чем на 175%, когда находится в раздутом состоянии. ! 5. Устройство по п.3, в котором надувной баллон имеет увеличение объема примерно на 50-150%, когда находится в раздутом состоянии. ! 6. Устройство по п.1, в котором надувной баллон имеет увеличение на, по меньшей мере, около 25%, когда находится в раздутом состоянии. ! 7. Устройство по п.1, в котором надувной баллон содержит рентгеноконтрастный материал между двумя слоями. ! 8. Устройство по п.1, в котором указанные слои баллона составляют прим РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2009 137 581 (13) A (51) МПК A61N 5/10 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2009137581/14, 11.03.2008 (71) Заявитель(и): СИНОРКС, ИНК. (US) Приоритет(ы): (30) Конвенционный приоритет: 12.03.2007 US 11/716,758 ...

Verfahren und Vorrichtung zur Behandlung der Stenose oder anderen Verengungen eines Körperkanals

Modularer Applikator für die Brachytherapie

Die Erfindung bezieht sich auf einen modularen Applikator (15) zur Ermöglichung einer Brachytherapie-Behandlung, umfassend einen zentralen Kern (8) und eine äußere Hülse (9), wobei der zentrale Kern mit einem Befestigungsmechanismus (8a) angepasst ist, um die äußere Hülse am zentralen Kern zu befestigen, und wobei die äußere Hülse aus einem im Wesentlichen steifen oder formbaren Material gefertigt ist.

Selbstexpandierendes Medizingerät

Medical appliances for the treatment of blood vessels by means of ionizing radiation

Catheter with stand-off structure

Catheter with stand-off structure

Energy filtering system

INTRAVASCULAR RADIATION DELIVERY SYSTEM

An intravascular radiation delivery system including a catheter, a radiation source disposed in an open-ended lumen in the catheter and a closed-ended sheath surrounding the radiation source so as to prevent blood and other fluids from coming into contact with the radiation source. Preferably, the open-ended lumen is centered in the balloon for uniform radiation delivery. The catheter may include a blood perfusion lumen under the balloon or around the balloon. The open-ended lumen in the catheter may have a reduced diameter adjacent the distal end of the catheter to prevent the radiation source from exiting the lumen. Methods of using the radiation delivery system are also disclosed. An alternative method of delivering radiation to a treatment site inside the vasculature of a patient using a gas-filled balloon catheter and a radiation source disposed in the balloon catheter. The treatment site is exposed to radiation, preferably beta radiation, through the gas-filled balloon.

BRACHYTHERAPY TANDEM AND OVOID IMPLANTATION DEVICES AND METHODS

Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section suitable for retaining within a body cavity such as the uterus, both during radiation treatment and during recovery time between radiation treatments. This distal portion can be intended for single-patient use and be disposed of after completion of a radiation treatment session having multiple radiation dose treatment times. One or both of real time in vivo detection and monitoring and hytpertherapy features can be included. One or more of the system tandem or ovoid colpostats feature bendability to tailor the system to the specific body and patient being treated. The method includes having a tandem distal section inserted into a body cavity such as a uterus and remaining within the body cavity in between treatment times. Other systems and methods incorporate balloon devices that assist in spacing radiation ...

CENTERING BALLOON CATHETER

In accordance with the present invention, there is provided a catheter for insertion into a vessel of a patient. The catheter has distal and proximal ends and includes an elongated flexible outer shaft and an elongated flexible inner shaft extending through the oute r shaft. The inner shaft has a central lumen extending therethrough. The catheter has first and secon d inflation lumens extending through at least one of the inner and outer shafts. The catheter includes an inflatable outer balloon disposed at its distal end. The outer balloon is in fluid communication with the first inflation lumen for inflation and deflation thereof. The catheter further includes an inflatable inner balloon disposed within the outer balloon. The inner balloon is in fluid communicati on with the second inflation lumen for inflation and deflation thereof. The inner shaft of the catheter extends through the inner balloon. The inner balloon is a centering balloon and is able to center the distal end of the inner ...

RADIATION DOSE DELIVERY CATHETER WITH REINFORCING MANDREL

The invention is directed to a rapid exchange-type intravascular catheter suitable for maintaining patency of a body lumen for a period of time sufficient to permit delivery of a radiation source to the body lumen. The catheter utilized a reinforcing mandrel to improve the pushability and strength of the catheter as it tracks along a guide wire, and permits blood flow through an inflatable member while radiation therapy is being provided.

DEVICE FOR THE INTRAVASCULAR TREATMENT OF RESTENOSES

L'invention concerne un dispositif pour le traitement intravasculaire de resténoses.Un tel dispositif est caractérisé en ce qu'une zone porteuse (22) du tuyau ou de la source de rayonnement est adjacente à cette zone d'extension (21) expansible en forme de ballon, en direction opposée à l'extrémité distale (101) , sur laquelle (zone porteuse) une ou plusieurs source (s) de rayonnement (1) entourant cette dernière sur tous les côtés est placée ou sont placées pour l'émission du rayonnement ionisant désiré.

CATHETER SYSTEM HAVING TUBULAR RADIATION SOURCE

A radiation source for inhibiting restenosis including a radiation delivery tube (20) having a radioactive distal region (24), the tube (20) being adapted to slide over a guide wire (28) within a radiation delivery catheter (42). In use, the catheter (42) is advanced to a site to be treated, the balloon (54) inflated, and the radioactive tube (20) advanced over the radiation source guide wire (28) within the lumen (50).

Multi-purpose catheters, catheter systems, and radiation treatment

This invention is new apparatuses and methods for treatments to be used from inside conduits or biological pathways. Examples of the biological pathways in which these new apparatuses and methods may be used include arteries, veins, and respiratory ways. Multi-purpose catheters (10) and catheter systems using structures including wires (2108), balloons (2150), and cords (2204) are described as well as methods to use such catheters and catheter systems. One of the embodiments is a configurable wire system which carries or transports radioactive sources. The wire is used in conjunction with a closed-end channel catheter.

Radiation-emitting flow-through temporary stent

Methods and apparatuses for radiation treatment

Radiation catheter with multilayered balloon

Medical appliance for the treatment of a portion of the body vessel by ionizing radiation

Device for loading and centering of a vascular radiation therapy source

Brachytherapy device for facilitating asymmetrical irradiation of a body cavity

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

Multi-lumen instrument for providing radiation to a body cavity

A brachytherapy system for treating metastases on and around a patient's spinous process is provided. The device generally includes a catheter member having a proximal portion, a distal portion, and at least one lumen extending therethrough. The distal portion of the catheter member includes first and second branch members that are adapted to be positioned on opposed sides of a patient's spinous process. The device further includes first and second elongate anchoring elements disposed on the first and second branch members, and optionally can include at least one centering mechanism disposed within each of the first and second anchoring elements.

Radiation catheter with multilayered balloon

A catheter device for irradiating tissue surrounding a body site within a body of a patient, includes an elongated shaft which has a distal portion configured to be deployed within the body site. A treatment location at the distal portion has one or more radiation guides configured to receive a radiation source to irradiate tissue at least in part surrounding the body site. An inflatable multilayered balloon is located to surround the treatment location with a wall thereof having at least two layers including a first layer separate from, inside, and in contact with a second layer around an entire periphery of the first layer, and each of the first layer and the second layer being secured to the distal portion of the elongated shaft.

INTRACAVITY BALLOON CATHETER

An intracavity balloon catheter may include a flexible catheter and a balloon provided on a distal end of the flexible catheter. The balloon may be inflatable with the introduction of fluid into the balloon from the flexible catheter. The balloon may be composed of a plurality of sections, including a center section and side sections. The inflated balloon may have shapes such as cylindrical, semi-cylindrical, or pillow shape. The intracavity balloon catheter may further include a securing device, such as a positioning ring, for securing the position of an inserted intracavity balloon catheter. This securing device may be composed of two, matable components with a passage extending through. The flexible catheter may be insertable into the passage. Tabs may be provided, either on one of the components or on a locking mechanism provided between the components, to prevent sliding of an inserted flexible catheter. 111-. (canceled)12. An intracavity balloon catheter comprising: a flexible catheter having a proximal catheter portion and an intermediate catheter portion , and a fluid passageway between the intermediate catheter portion and the proximal catheter portion; and a balloon disposed at the intermediate catheter portion , the balloon having an exterior balloon surface comprising a posterior surface and an anterior surface opposed to the posterior surface , the balloon composed of a center section and at least two side sections , wherein the balloon is inflatable between a deflated condition and an inflated condition by introduction of a fluid into the balloon from the intermediate catheter portion , the exterior balloon surface having a deflated posterior position and a deflated anterior position in the deflated condition , and the exterior balloon surface having an inflated posterior position and an inflated anterior position in the inflated condition , wherein the inflated posterior position and the inflated anterior position of the center section are ...

Multi-purpose balloon catheter for intra cavity radiation delivery

A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated and deflated to position and stabilize the catheter in a cavity for delivery of a treatment. The catheter can include an extraction point associated with a lumen to remove fluids and material from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a liquid saline solution, a fluid medium, or a radioactive isotope provided to a corresponding lumen for delivery of the treatment.

DUAL DOUBLE BALLOON CATHETER

A dual double balloon catheter includes a catheter having a proximal end portion, a central portion and a distal end portion. The catheter includes a plurality of lumens within the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the distal end portion, and the balloons being communicatively connected with a corresponding one of the plurality of lumens to selectively inflate/deflate the corresponding inflatable balloon, wherein one or more of inflatable balloons further includes a second one of the plurality lumens associated with a corresponding inner wall of a corresponding inflatable balloon and adapted to receive a radioactive dose or a therapeutic agent for a treatment. The plurality of balloons can have varying sizes in relation to each other and also include lumens within or associated with the inner walls of the balloons to deliver a treatment. 1. A dual double balloon catheter , comprising:a catheter having a proximal end portion, a central portion and a distal end portion;a plurality of lumens positioned in association with the catheter extending from the proximal end portion of the catheter; anda plurality of inflatable balloons positioned in association with the central portion of the catheter, the plurality of inflatable balloons each being configured to be filled with an inflation medium to enable selectively inflating and deflating one or more of the plurality of inflatable balloons independently of at least one other of the plurality of inflatable balloons to selectively one or more of position or stabilize the catheter in a cavity for a treatment, each of the plurality of inflatable balloons being configured to be positioned spaced from each other in a longitudinal direction along the length of the catheter,wherein one or more of the plurality of inflatable balloons further includes at least one of other of the plurality of lumens configured to respectively receive a ...

VALIDATION OF THERAPEUTIC RADIATION TREATMENT

Validation of a therapeutic radiation treatment involves using an applicator balloon surrounding an X-ray radiation source to support a plurality of X-ray sensor elements (XRSE). The XRSE are supported on the applicator balloon at distributed locations to sense applied radiation from the radiation source. At least one parameter of the applied radiation which has been sensed by the XRSE is compared to a corresponding parameter of a predetermined radiation treatment plan. Based on the comparing, a determination is made as to whether one or more requirements of the predetermined radiation treatment plan have been satisfied. 1. A method for validation of a therapeutic radiation treatment , comprising:using an applicator balloon surrounding a radiation source which produces X-rays to control a distance between the radiation source and patient tissue comprising a radiation treatment site;using a plurality of X-ray sensor elements (XRSE) supported on the applicator balloon at a plurality of distributed locations to sense applied radiation from the radiation source;comparing at least one parameter of the applied radiation which has been sensed by the XRSE to a corresponding parameter of a predetermined radiation treatment plan;based on the comparing, determining if one or more requirements of the predetermined radiation treatment plan have been satisfied.2. The method according to claim 1 , wherein the at least one parameter is selected from the group consisting of a duration of the applied radiation claim 1 , an intensity of the applied radiation claim 1 , and a three-dimensional radiation pattern associated with the applied radiation.3. The method according to claim 1 , wherein the comparing involves comparing a plurality of sensed radiation intensity values detected in each of a plurality of different beam vector directions extending from the radiation source claim 1 , to a plurality of corresponding expected radiation intensity values for the plurality of different beam ...

BRACHYTHERAPY DEVICE FOR FACILITATING ASYMMETRICAL IRRADIATION OF A BODY CAVITY

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity. 145.-. (canceled)46. A method comprising:inserting at least partially into a body cavity a device comprising a shaft and an inflatable member disposed about a portion of the shaft;inflating the inflatable member such that at least a portion of the inflatable member at least partially contacts tissue that defines the body cavity;expanding away from an axis of the shaft, spaced apart from but within the inflatable member, a radiation delivery tube; andinserting a radiation source into the radiation delivery tube.47. The method of claim 46 , wherein expanding the radiation delivery tube comprises not contacting an inner surface of the inflated inflatable member.48. The method of claim 46 , wherein the radiation tube is disposed in the shaft and wherein the shaft is deflectable away from the axis.49. The method of claim 48 , further comprising pulling a pull wire so as to expand the radiation delivery tube.50. The method of claim 46 , further comprising pushing the radiation delivery tube into the lumen so as to expand the radiation delivery tube.51. The method of claim 46 , wherein claim 46 , prior to expansion of the radiation delivery tube claim 46 , the radiation delivery tube is disposed in a compartmented support element that extends between a proximal end and a distal end of the balloon.52. The method of claim 51 , wherein the compartmented support element defines a compartment that extends longitudinally along the compartmented support element.53. A method comprising:inserting at ...

CATHETER-ASSISTED TUMOR TREATMENT

A method for treating a subject diagnosed with a cancer or other disorder comprising a hyperproliferative tissue is described herein. The method includes localized delivery of a material which contains a therapeutically effective agent and/or moiety. The localized delivery of the agent is achieved using a catheter-based delivery system and an implant. An implant can include a support component, a cover component, and a valve component. The valve component can be operable to permit flow through the implant. The implant can be delivered on a catheter, with one of the ends of the implant being selectively expanded to permit temporary occlusion of a vessel while delivering a material through the valve component to a downstream target region. The other end of the implant can thereafter be released such that the implant occludes the vessel, or the implant can be removed from the vessel entirely. 1. A method for treating a subject diagnosed with a cancer , comprising:advancing an implant to a target region of a body lumen which is near or contains the cancer, the implant having first and second sections engaged with a catheter at respective first and second engagement points;releasing the implant first section from engagement with the catheter at the first engagement point;permitting the implant first section to expand against a lumen wall at the target region such that the lumen becomes at least substantially occluded; andinjecting a therapeutic material through a portion of the implant, wherein the material is effective to treat the cancer.2. The method of claim 1 , wherein the implant first section comprises an implant distal section claim 1 , and wherein the releasing comprises disengaging a first engagement member from the distal section.3. The method of claim 1 , wherein the portion of the implant comprises a valve component and the permitting comprises causing the valve component to contact a distal end of the catheter such that the catheter distal end moves the ...

MONOLITHINC PHOTODETECTOR FOR DOSIMETER

Detectors, system and methods for measuring radiation using plastic scintillating sensors with a detector unit that uses photodiodes and MPPC detectors instead of a CCD camera, and thus avoids the use of all free space optics. 1. A dosimetry detector system , comprisinga housing comprising a light sensor and a processor;a radiation sensor cable comprising a scintillating fiber;wherein the light sensor is configured to measure light emitted by the scintillating fiber;wherein the light sensor is configured to generate an electrical signal in response to the measured light; and{'b': '1', 'wherein the processor is configured to convert the electrical signal into a calculated radiation dose measurement in less than second.'}2. The dosimetry detector system of claim 1 , wherein the processor is configured calculate the radiation dose measurement in at least 0.002 seconds.3. The dosimetry detector system of claim 1 , further comprising:wherein the calculated radiation dose measurement is time-resolved at a rate of up to at least 500 measurements per second.4. The dosimetry detector system of claim 1 , wherein the light sensor is a multi-pixel photon counter claim 1 , a photodiode or a photomultiplier tube.5. The dosimetry detector system of claim 1 , further comprising a display unit.6. The dosimetry detector system of claim 5 , wherein the display unit is configured to display the calculated radiation dose measurement to a user in real-time.7. The dosimetry detector system of claim 1 , wherein the radiation sensor cable is configured to be operably connected to the housing.8. The dosimetry detector system of claim 1 , wherein the housing further comprises a power supply.9. The dosimetry detector system of claim 1 , wherein the radiation sensor cable is configured to be calibrated.10. The dosimetry detector system of claim 1 , wherein the housing further comprises a lead shielding.11. The dosimetry detector system of claim 1 , wherein the electrical signal may comprise ...

INTERNAL BODY CAVITY THERAPEUTIC APPLICATOR ARRANGEMENTS AND METHODS FOR USING THE SAME

An apparatus for providing at least one treatment to at least one tissue having a first structural arrangement configured to expand a first portion at a distal end of the apparatus, a second structural arrangement configured to expand a second portion at the distal end and at least one lumen associated with at least one of the first structural arrangement and/or the second structural arrangement. The first structural arrangement and/or the second structural arrangement can be configured to position the at least one lumen at a particular position with respect to the tissue. A tip is configured to aid in the insertion of the apparatus into the tissue(s). 137.-. (canceled)38. An apparatus for providing at least one treatment to at least one tissue , comprising:a first inflation arrangement configured to expand a first portion at a distal end of the apparatus;a second inflation arrangement configured to expand a second portion at the distal end; andat least one lumen extending from a proximal end of the apparatus to the distal end, and having an opening at the proximal end, wherein the at least one lumen is located between and separate from the first inflation arrangement and the second inflation arrangement;wherein the first inflation arrangement is configured to position the at least one lumen at a particular position with respect to the at least one tissue based on an expansion of the first portion, and wherein the second inflation arrangement is configured to position the at least one lumen at the particular position with respect to the at least one tissue based on an expansion of the second portion, andwherein at least one of the first inflation arrangement or the second inflation arrangement is a baffle filled with at least one of sterile water or air.39. The apparatus of claim 38 , further comprising a tip portion provided at the distal end and configured to facilitate an insertion of the apparatus into the at least one tissue.40. The apparatus of claim 38 , ...

Intracavity balloon catheter

An intracavity balloon catheter may include a flexible catheter and a balloon provided on a distal end of the flexible catheter. The balloon may be inflatable with the introduction of fluid into the balloon from the flexible catheter. The balloon may be composed of a plurality of sections, including a center section and side sections. The inflated balloon may have shapes such as cylindrical, semi-cylindrical, or pillow shape. The intracavity balloon catheter may further include a securing device, such as a positioning ring, for securing the position of an inserted intracavity balloon catheter. This securing device may be composed of two, matable components with a passage extending through. The flexible catheter may be insertable into the passage. Tabs may be provided, either on one of the components or on a locking mechanism provided between the components, to prevent sliding of an inserted flexible catheter.

BRACHYTHERAPY DEVICES AND METHODS FOR THERAPEUTIC RADIATION PROCEDURES

Radiation therapy or brachytherapy devices, systems and methods are in general catheter form and include at least one balloon that assists in placement of radio therapeutic members at desired treatment locations within an existing body cavity or at a site that was formed under a patient's skin for treatment purposes. One or more detectors, such as microdiodes, are present on the device, and a hyperthermia tube or the like is also included that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member.

INTERNATIONAL BODY CAVITY THERAPEUTIC APPLICATOR ARRANGEMENTS AND METHODS FOR USING THE SAME

An apparatus for providing at least one treatment to at least one tissue having a first structural arrangement configured to expand a first portion at a distal end of the apparatus, a second structural arrangement configured to expand a second portion at the distal end and at least one lumen associated with at least one of the first structural arrangement and/or the second structural arrangement. The first structural arrangement and/or the second structural arrangement can be configured to position the at least one lumen at a particular position with respect to the tissue. A tip is configured to aid in the insertion of the apparatus into the tissue(s).

INTERNAL BODY CAVITY THERAPEUTIC APPLICATORS AND METHODS FOR USING THEM

An apparatus for providing treatment to at least one tissue includes a distal balloon, a proximal balloon, and at least one intermediate balloon positioned between the distal balloon and the proximal balloon and inflatable independently from the distal and proximal balloons. A source lumen is positioned within at least the intermediate balloon receives a radiation source to treat target tissue adjacent the intermediate balloon. 1. An apparatus for providing treatment to at least one tissue , comprising:a distal balloon;a proximal balloon; andat least one intermediate balloon positioned between the distal balloon and the proximal balloon, the at least one intermediate balloon being inflatable independently from the distal and proximal balloons;a source lumen adapted and configured to receive a radiation source, the source lumen positioned within at least the at least one intermediate balloon.2. The apparatus of wherein the distal and proximal balloons are each independently inflatable.3. The apparatus of wherein at least one of the distal claim 1 , at least one intermediate and proximal balloons has a diameter different from the other of the distal claim 1 , at least one intermediate and proximal balloons.47-. (canceled)8. A method of providing treatment to at least one tissue claim 1 , the method comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'positioning the at least one intermediate balloon of the apparatus of adjacent tissue to be treated;'}inflating one or more of the distal balloon, the at least one intermediate balloon, or the proximal balloon; andinserting a radiation source via the source lumen within at least the at least one intermediate balloon to expose the tissue to be treated to radiation.913-. (canceled)14. A hub for use with a multi-lumen applicator comprising:an outer body having a longitudinal axis and an inner surface defining a first portion of a plurality of longitudinally extending channels, the outer body further defining a ...

MULTI-PURPOSE BALLOON CATHETER FOR INTRA CAVITY RADIATION DELIVERY

A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction point associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment. 1. A multi-purpose balloon intra-cavity catheter for a medical treatment , comprising:a single intra-cavity catheter configured for insertion into a body cavity for the medical treatment, the single intra-cavity catheter having a proximal end portion, a central portion and a non-branching distal end portion;a plurality of lumens positioned in association with the single intra-cavity catheter extending from the proximal end portion of the single intra-cavity catheter;a plurality of independent and distinct balloon groups positioned in association with the central portion of the single intra-cavity catheter, each independent and distinct balloon group being independently spaced from each of the other independent and distinct balloon groups on the single intra-cavity catheter, each independent and distinct balloon group is positioned in a non-overlapping contiguous arrangement on a same longitudinal axis of the single intra-cavity catheter, each independent and distinct balloon group including at least one ...

INTRACAVITY BALLOON CATHETER

An intracavity balloon catheter may include a flexible catheter and a balloon provided on a distal end of the flexible catheter. The balloon may be inflatable with the introduction of fluid into the balloon from the flexible catheter. The balloon may be composed of a plurality of sections, including a center section and side sections. The inflated balloon may have shapes such as cylindrical, semi-cylindrical, or pillow shape. The intracavity balloon catheter may further include a securing device, such as a positioning ring, for securing the position of an inserted intracavity balloon catheter. This securing device may be composed of two, matable components with a passage extending through. The flexible catheter may be insertable into the passage. Tabs may be provided, either on one of the components or on a locking mechanism provided between the components, to prevent sliding of an inserted flexible catheter. 1. An intracavity balloon catheter comprising:a flexible catheter having a proximal catheter portion, a distal catheter portion having a distal tip, and a fluid passageway between the distal tip and the proximal catheter portion; anda balloon disposed at the distal end of the catheter, the tip of the flexible catheter extending into the balloon, the balloon having an exterior balloon surface comprising a posterior surface and an anterior surface opposed to the posterior surface, the balloon composed of a center section and at least two side sections,wherein the balloon is inflatable between a deflated condition and an inflated condition by introduction of a fluid into the balloon from the distal tip of the flexible catheter, the exterior balloon surface having a deflated posterior position and a deflated anterior position in the deflated condition, and the exterior balloon surface having an inflated posterior position and an inflated anterior position in the inflated condition.2. The intracavity balloon catheter of claim 1 , wherein the inflated posterior ...

MULTI-PURPOSE BALLOON CATHETER FOR INTRA CAVITY RADIATION DELIVERY

A multi-purpose balloon catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction point associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment. 1. A multi-purpose balloon intra-cavity catheter for a medical treatment , comprising:a single intra-cavity catheter configured for insertion into a body cavity for the medical treatment, the single intra-cavity catheter having a proximal end portion, a central portion and a non-branching distal end portion;a plurality of lumens positioned in association with the single intra-cavity catheter extending from the proximal end portion of the single intra-cavity catheter;a plurality of independent and distinct balloon groups positioned in association with the central portion of the single intra-cavity catheter, each independent and distinct balloon group including at least one inflatable balloon, and each independent and distinct balloon group being communicatively associated with a corresponding at least one of the plurality of lumens;an applicator extender communicatively associated with the non-branching distal end portion of the single intra-cavity catheter, the applicator extender being configured to be in ...

URINARY CATHETER FOR DETECTING RADIATION

Interstitial brachytherapy is a cancer treatment in which radioactive material is placed directly in the target tissue of the affected site using an afterloader. The accuracy of this placement is monitored in real time using a urinary catheter that locates the radioactive material according to the radiation levels measured by sensors in the walls of the urinary catheter. A scintillator that is embedded in the walls of the urinary catheter produces light when irradiated by the radioactive material. This light is proportional to the level of radiation at each location. The light produced by each scintillator is carried through optical fibers and then converted to an electrical signal that is proportional to the light and the radiation level at each location. The radioactive material is located according to the plurality of electrical signals. This location can be used as quality control feedback to the afterloader. 1. A urinary catheter for detecting radiation produced by a radiation source that is controlled by an afterloader , the urinary catheter comprising:a plurality of scintillators embedded into the walls of the urinary catheter; and each scintillator is configured to produce light in a presence of radiation from the radiation source,', 'a level of the light produced by each scintillator is proportional to a level of the radiation incident to each scintillator;', 'each optical fiber of the plurality of optical fibers is operably coupled to a scintillator of the plurality of scintillators,', 'each optical fiber of the plurality of optical fibers is operably coupled to a light detection unit of a plurality of light detection units,', 'each light detection unit is configured to produce an electrical signal in a presence of the light from one scintillator of the plurality of scintillators,', 'a level of the electrical signal produced by each light detection unit is proportional to the light incident to each light detection unit; and', 'a location of the radiation ...

BEAM HARDENING FOR INTRAOPERATIVE RADIATION THERAPY USING A BALLOON APPLICATOR

A balloon applicator for an intraoperative radiation therapy system includes an x-ray beam shaping component for emitting x-rays in a plurality of possible directions in three dimensions. The balloon applicator includes connecting structure for connecting to the intraoperative radiation therapy system and an inflatable balloon contactor having an outer surface. The balloon applicator has a beam hardening system including a beam hardening compound disposed between the x-ray beam shaping component and the outer surface of the balloon. The beam hardening system is capable of hardening the beam in beam directions in three dimensions. An intraoperative radiation therapy system and a method for conducting intraoperative radiation therapy are also disclosed. 1. A balloon applicator for an intraoperative radiation therapy system comprising an x-ray beam shaping component for emitting x-rays in a plurality of possible directions in three dimensions , the balloon applicator comprising an inflatable balloon contactor having an outer surface and comprising a beam hardening system comprising a beam hardening compound disposed between the x-ray beam shaping component and the outer surface of the balloon , the beam hardening system being capable of hardening the beam in beam directions in three dimensions.2. The balloon applicator of claim 1 , wherein the beam hardening system comprises a beam hardening compound claim 1 , the beam hardening compound being provided in an inflation fluid for inflating the balloon contactor.3. The balloon applicator of claim 1 , wherein the balloon contactor comprises a balloon wall and the beam hardening system comprises a beam hardening layer on an inner surface of the balloon wall claim 1 , the beam hardening layer comprising a beam hardening compound.4. The balloon applicator of claim 1 , wherein balloon contactor comprises a balloon wall and the beam hardening system comprises a beam hardening layer on an outer surface of the balloon wall.5. The ...

BALLOON CATHETER SYSTEM AND METHOD FOR OPTICAL TUMOR TREATMENT

A balloon catheter system includes: a light irradiation probe including, at a distal end portion of a fiber probe, a light irradiation portion for irradiating light; a balloon catheter including a shaft having a through hole through which the light irradiation probe is insertable, the through hole allowing liquid feeding, with the light irradiation probe being arranged, and a balloon provided to the shaft and configured to be expandable and contractable by a liquid injected into the balloon; and an injection apparatus including a measuring portion capable of measuring a quantity of the liquid, and an injection portion for injecting the liquid measured by the measuring portion into the balloon, and the balloon expands by the injected liquid, to thereby extend a wall of a region to be treated and retain the wall of the region to be treated in an extended state. 1. A balloon catheter system comprising:a light irradiation probe including, at a distal end portion of a fiber probe, a light irradiation portion configured to irradiate light;a balloon catheter including a shaft and a balloon, the shaft including a through hole in which the light irradiation probe is arrangeable, the through hole being configured to allow liquid feeding, with the light irradiation probe being arranged in the through hole, the balloon being fixed to one end portion of the shaft and configured to be expandable and contractable by a liquid injected through the through hole of the shaft; andan injection apparatus including a measuring portion configured to be capable of measuring a quantity of the liquid to be injected into the balloon, and an injection portion configured to inject the liquid measured by the measuring portion into the balloon through the through hole,wherein the balloon expands by the liquid injected into the balloon, to thereby extend a wall of a region to be treated, and the expanded balloon retains the wall of the region to be treated in an extended state.2. The balloon ...

SURGICAL CAVITY SIZERS FOR BRACHYTHERAPY AND INTRAOPERATIVE RADIATION THERAPY

Surgical cavity sizers for selecting a radiation applicator for brachytherapy and intraoperative radiation therapy. The surgical cavity sizer has a head portion and a handle portion monolithic to the head portion. The surgical cavity sizer is composed of biocompatible and sterilizable material. A method for selecting a radiation applicator as well as a container for a surgical cavity sizer and/or a radiation applicator are also disclosed. 1. A device for intraoperative radiation therapy and brachytherapy , comprising: a surgical cavity sizer for a radiation applicator having a distal end to be located in a surgical cavity and allowing radiation emission therethrough , said surgical cavity sizer including a head portion having a shape and a size identical to the distal end of the radiation applicator , and a handle portion projecting from the head portion and permitting manipulation of the surgical cavity sizer , the handle portion being integrally formed with the head portion to form a monolithic structure composed of a biocompatible and sterilizable material.2. The device of claim 1 , wherein the head portion has a spherical shape.3. The device of claim 2 , wherein the head portion has a diameter between about 1.5 cm to about 5.0 cm.4. (canceled)5. (canceled)6. The device of claim 1 , further comprising a connector portion located between the head portion and the handle portion and being monolithic to the head portion and the handle portion.7. A container for a device for intraoperative radiation therapy and brachytherapy claim 1 , the device including a surgical cavity sizer or a radiation applicator claim 1 , said container comprising a pivoting engagement mechanism retaining the device claim 1 , the pivoting engagement mechanism operable to pivot the device between a storage position claim 1 , wherein a longitudinal axis of the device is disposed fully within the container claim 1 , and a releasable position claim 1 , wherein the device is in an angled claim 1 , ...

USING A GUIDED MEMBER TO FACILITATE BRACHYTHERAPY DEVICE SWAP

A guide member facilitates a device swap for brachytherapy treatment. A cavity evaluation device is introduced during surgery such that a distal end of the device is disposed in a resected cavity of the patient. The cavity evaluation device includes a shaft in which is disposed an elongated guide member. In a subsequent out-patient procedure the cavity evaluation device is removed from the resected cavity. If a brachytherapy treatment is to be performed then the cavity evaluation device is removed without removing the elongated guide member such that position of a portion of the elongated guide member in the resected cavity is maintained relative to the resected cavity. An anchor member helps to maintain the position of the guide member. Introduction of a brachytherapy catheter is then facilitated by introducing the elongated guide member into an opening of the brachytherapy catheter and using the elongated guide member to guide the brachytherapy catheter to the resected cavity. 19.-. (canceled)10. An apparatus for facilitating brachytherapy treatment comprising:an elongated guide member comprising a guide wire and a non-inflatable anchor member at a distal end of the guide wire, wherein the non-inflatable anchor member comprises a curvature; and a shaft defining a lumen configured to slidably receive the elongated guide member;', 'a tip disposed at a first end of the shaft, wherein the tip comprises an outer curvature configured to mate with the non-inflatable anchor curvature when the elongated guide member is received in the lumen;', 'an inflatable member disposed around the shaft;', 'an inflation lumen which transfers fluid into and out of the inflatable member; and', 'an opening in the tip which receives the elongated guide member, and via which the elongated guide member can be introduced to soft tissue, wherein the opening is sized so as to receive all but the non-inflatable anchor member of the elongated guide member., 'a device comprising11. The apparatus ...

MULTI-PURPOSE BALLOON CATHETER FOR INTRA CAVITY RADIATION DELIVERY

A multi-purpose balloon intra-cavity catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction opening associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment. 1. A multi-purpose balloon intra-cavity catheter for a medical treatment , comprising:a single intra-cavity catheter configured for insertion into a body cavity for the medical treatment, the single intra-cavity catheter having a proximal end portion, a central portion and a non-branching distal end portion;a plurality of lumens positioned in association with the single intra-cavity catheter extending from the proximal end portion of the single intra-cavity catheter;a plurality of independent and distinct balloon groups positioned in association with the central portion of the single intra-cavity catheter, each of the plurality of independent and distinct balloon groups including at least one inflatable balloon, and each of the plurality of independent and distinct balloon groups being communicatively associated with a corresponding at least one of the plurality of lumens; anda secondary treatment balloon communicatively associated with the non-branching distal end portion of the single intra- ...

RADIATION MODULATOR AND METHODS OF USE AND PRODUCTION THEREOF

The present disclosure is directed to a computer-implemented method for designing a patient-specific brachytherapy (BT) tandem applicator. The method is implemented using at least one processor in communication with at least one memory. The method includes receiving a radiation treatment plan for treating a region of interest. The radiation treatment plan includes a prescribed radiation dosage and patient anatomical data of the region of interested to be treated. The method also includes applying an inverse planning optimization model to determine an optimal thickness of an interior surface of the tandem applicator at a plurality of dwell positions within the region of interest. The method also includes generating a schedule of dwell times for the tandem applicator based on the generated position-dependent thickness profile. The method also includes transmitting design instructions to a 3D printer for fabrication of the tandem applicator. 1. A patient-specific intensity-modulated high dose rate (HDR) brachytherapy applicator for administering an HDR brachytherapy treatment to a patient , the applicator comprising a plurality of shielding segments distributed along a central longitudinal axis , each shielding segment corresponding to one dwell position and comprising a shielding wall , each shielding wall comprising a plurality of equiangular shielding sections of varying thickness distributed circumferentially about the central longitudinal axis , each equilangular shielding section comprising a shielding thickness , wherein each shield thickness of each equiangular shielding section at each shielding segment is configured to transmit radiation from an HDR source positioned within each shielding segment into the patient at a predetermined dose rate distribution to administer the HDR brachytherapy treatment.2. The applicator of claim 1 , wherein each shield thickness of each equiangular shielding section is independently determined using a computer-implemented ...

INTERNAL BODY CAVITY THERAPEUTIC APPLICATOR ARRANGEMENTS AND METHODS FOR USING THE SAME

An apparatus for providing at least one treatment to at least one tissue having a first structural arrangement configured to expand a first portion at a distal end of the apparatus, a second structural arrangement configured to expand a second portion at the distal end and at least one lumen associated with at least one of the first structural arrangement and/or the second structural arrangement. The first structural arrangement and/or the second structural arrangement can be configured to position the at least one lumen at a particular position with respect to the tissue. A tip is configured to aid in the insertion of the apparatus into the tissue(s). 137-. (canceled)38. An apparatus for providing at least one treatment to at least one tissue , comprising:a first inflation arrangement configured to expand a first portion at a distal end of the apparatus;a second inflation arrangement configured to expand a second portion; andat least one lumen extending from a proximal end of the apparatus to the distal end, and having an opening at the proximal end, wherein the at least one lumen is located between and separate from the first inflation arrangement and the second inflation arrangement;wherein the first inflation arrangement is configured to position the at least one lumen at a particular position with respect to the at least one tissue based on an expansion of the first portion, and wherein the second inflation arrangement is configured to position the at least one lumen at the particular position with respect to the at least one tissue based on an expansion of the second portion, andwherein at least one of the first inflation arrangement or the second inflation arrangement is filled with at least one of sterile water or air.39. The apparatus of claim 38 , further comprising a tip portion provided at the distal end and configured to facilitate an insertion of the apparatus into the at least one tissue.40. The apparatus of claim 38 , wherein the second inflation ...

MULTI-BALLOON CATHETER FOR MEDICAL APPLICATIONS

According to one general aspect, there is a multi-balloon catheter for medical applications that includes a multi-balloon inflator that inflates multiple balloons on a single catheter, an extraction point used to remove human fluids from the human body, and a connecting point that allows a syringe or a machine to insert air or any other liquid, such as a liquid saline solution, for inflation of a corresponding balloon of the multiple balloons or insert radioactive isotopes into the multi-balloon inflator. 1. A medical device , comprising:a catheter configured for insertion into a body cavity; a multi-balloon inflator that selectively inflates the plurality of inflatable balloons associated with the catheter; and', 'a plurality of connections associated with the multi-balloon inflator and configured to enable insertion of the liquid, the air or the radioactive material into corresponding ones of the plurality of inflatable balloons through the multi-balloon inflator, the plurality of connections being configured to respectively inflate each of the plurality of inflatable balloons to a corresponding size or shape relative to a location of the catheter while the catheter is positioned in the body cavity., 'a plurality of inflatable balloons associated with the catheter, the plurality of inflatable balloons each being configured to be filled with a liquid or air to selectively fix or position the catheter in the body cavity or with a radioactive material to selectively deliver by the radioactive material a radiation dose to tissue, each of the plurality of inflatable balloons being configured to be positioned spaced from each other on the catheter;'}2. (canceled)3. (canceled)4. (canceled)5. The medical device of claim 1 , further comprising:an extraction opening connection associated with the multi-balloon inflator in communication with an extraction opening of the catheter configured to remove bodily fluid from the body cavity while the catheter is positioned in the ...

MULTI-PURPOSE BALLOON CATHETER FOR INTRA CAVITY RADIATION DELIVERY

A multi-purpose balloon intra-cavity catheter includes a catheter having a proximal end portion, a central portion and a non-branching distal end portion, a plurality of lumens associated with the catheter extending from the proximal end portion, and a plurality of inflatable balloons positioned in the central portion and/or the non-branching distal end portion. Each of the plurality of inflatable balloons is communicatively associated with a corresponding one of the plurality of lumens, the plurality of inflatable balloons being selectively inflated or deflated to position and stabilize the catheter in a cavity for delivery of a medical treatment. The catheter can include an extraction opening associated with a lumen to remove fluids and materials from the cavity, and a connector associated with a corresponding lumen adapted to selectively receive one or more of a fluid medium or a radioactive isotope provided to a corresponding lumen for delivery of the medical treatment. 1. A multi-purpose balloon intra-cavity catheter for a medical treatment , comprising:a single intra-cavity catheter having a proximal end portion, a central portion and a non-branching distal end portion;a plurality of lumens positioned in association with the single intra-cavity catheter extending from the proximal end portion of the single intra-cavity catheter;a plurality of independent and distinct balloon groups positioned in association with the central portion of the single intra-cavity catheter, each of the plurality of independent and distinct balloon groups including at least one inflatable balloon, and each of the plurality of independent and distinct balloon groups being communicatively associated with a corresponding at least one of the plurality of lumens; anda secondary treatment balloon assembly communicatively associated with the non-branching distal end portion of the single intra-cavity catheter, the secondary treatment balloon assembly having a secondary treatment balloon ...

BRACHYTHERAPY DEVICES AND METHODS FOR THERAPEUTIC RADIATION PROCEDURES

Radiation therapy or brachytherapy devices, systems and methods are in general catheter form and include at least one balloon that assists in placement of radio therapeutic members at desired treatment locations within an existing body cavity or at a site that was formed under a patient's skin for treatment purposes. One or more detectors, such as microdiodes, are present on the device, and a hyperthermia tube or the like is also included that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member. 1. A therapeutic catheter , comprising:a catheter body that is configured to not deform under pressure encountered during passage from an insertion location to a target location within a radiation treatment subject for radiation therapy at the target location, the catheter body having an outside surface;one or more radio therapeutic sources having prescribed radioactivity, wherein the radio therapeutic source is a liquid source of radiation;a therapeutic balloon associated with the catheter body, said therapeutic balloon having a proximal end portion and a distal end portion, said therapeutic balloon being configured to receive one or more of the radio therapeutic sources, said therapeutic balloon and catheter body configured to have sufficient axial strength and radial extendibility to position the radio therapeutic member for radiation therapy when the balloon is inflated;an inflation tube which permits inflation and deflation of said therapeutic balloon while the therapeutic catheter is within a radiation treatment subject;at least one detector that collects data on radiation at a treatment location of the therapeutic catheter;a hyperthermia component that delivers hyperthermia treatment that interacts with radiation delivery by the radiation ...

FLUIDIZED BRACHYTHERAPY SYSTEM AND METHOD

The invention describes method for delivering and positioning radio-isotopes. The method uses encapsulating free flowing medicament into a leak proof vehicle and positioning the vehicle into the body. Also provided is a system for delivering and positioning radio-isotopes into the body, the system comprising fluid radio-isotope encapsulated in a leak proof material and/or absorbable material. 1. A method for delivering and positioning radio-isotopes into a body , the method comprising:a) encapsulating free flowing radio-isotope into an elongated leak proof vehicle; andb) positioning the vehicle into the body.2. The method as recited in wherein the vehicle comprises radioactive shielding material selected from the group consisting of nitinol claim 1 , platinum claim 1 , stainless steel claim 1 , tungsten claim 1 , coated polymers claim 1 , memory shaped substrates claim 1 , and combinations thereof.3. The method as recited in wherein the radio-isotope is a fluid.4. The method as recited in wherein the radio-isotope is a liquid-gas combination.5. The method as recited in wherein the vehicle comprises a plurality of tubes wherein the tubes are parallel with each other.6. The method as recited in wherein multiple vehicles are moved relative to each other after the vehicles are placed in the body.7. The method as recited in wherein the vehicle comprises an elongated semi rigid substrate encapsulated by a balloon.8. The method as recited in wherein the vehicle comprises a leak proof balloon positioned within an elongated semi rigid substrate.9. The method as recited in surfaces of the vehicle are overlaid with a sealant.10. A system for delivering and positioning radio-isotopes into the body claim 1 , the system comprising a free-flowing fluid radio-isotope encapsulated in an elongated leak proof substrate.11. The system as recited in wherein the substrate is a plurality of conduits claim 10 , each conduit defining a cross section shape selected from the group consisting ...

BALLOON APPLICATOR FOR DIRECTIONAL INTRAOPERATIVE AND BRACHY RADIATION THERAPY WITH CONFORMAL PHANTOM FOR 3D ANATOMICAL IMAGE REGISTRATION

A balloon applicator for intraoperative radiation therapy including a treatment head includes a connecting sleeve for attachment to the treatment head. The connecting sleeve has proximal and distal ends, the proximal end having an open end for receiving the treatment head. The distal end includes an inflatable balloon contactor for engaging patient tissue during intraoperative radiation therapy. At least one fluid port is provided for supplying and removing inflating fluid to the inflatable balloon contactor. A system and a method for conducting intraoperative radiation therapy are also provided. 1. A balloon applicator for directional intraoperative radiation therapy including a treatment head , comprising:a connecting sleeve for attachment to the treatment head, the connecting sleeve having proximal and distal ends, the proximal end having an open end for receiving the treatment head, the distal end comprising an inflatable balloon contactor for engaging patient tissue during intraoperative radiation therapy;at least one fluid port for supplying and removing inflating fluid to the inflatable balloon contactor.2. The balloon applicator of claim 1 , further comprising a safety interlock claim 1 , the safety interlock being sensible by cooperating structure on the treatment head to signal the presence of the balloon applicator.3. The balloon applicator of claim 2 , wherein the safety interlock is a protrusion for activating a mechanical switch on the treatment head.4. The balloon applicator of claim 2 , wherein the safety interlock is a radio frequency signaling device.5. The balloon applicator of claim 1 , further comprising at least one fiducial marker or a conformal fiducial marker phantom for 3D anatomical registration.6. The balloon applicator of claim 1 , further comprising an alignment tab for aligning the balloon applicator to the treatment head.7. The balloon applicator of claim 1 , further comprising a flange at the proximal end of the connecting sleeve.8. ...

Self-aligning medical device

A self-centering or alignment system for catheter or other medical treatment devices. The system includes magnets on interacting elongate devices to separate and align the elongate devices for use. The interactive elongate devices can include a guide catheter and treatment catheter or a treatment catheter and guide wire. The system of the present invention facilitates insertion and placement of medical devices at a treatment site and provides enhanced maneuverability and insertability for treatment devices.

Multi-purpose catheters, catheter systems, and radiation treatment

Tis invention is new apparatuses and methods for treatments to be used from inside conduits or biological pathways. Examples of the biological pathways in which these new apparatuses and methods may be used include arteries, veins, and respiratory ways. Multi-purpose catheters (10) and catheter systems using structures including wires (2108), balloons (2150), and cords (2204) are described as well as methods to use such catheters and catheter systems. One of the embodiments is a configurable wire system which carries or transports radioactive sources. The wire is used in conjunction with a closed-end channel catheter.

INTERNAL BODY CAVITY THERAPEUTIC APPLICATORS AND METHODS FOR USING THEM

An apparatus for providing treatment to at least one tissue includes a distal balloon, a proximal balloon, and an intermediate balloon positioned between the distal balloon and the proximal balloon and inflatable independently from the distal and proximal balloons. A source lumen is positioned within at least the intermediate balloon receives a radiation source to treat target tissue adjacent the intermediate balloon. 113-. (canceled)14. An apparatus for providing radiation treatment to an anatomical lumen comprising muscular tissue , comprising:a distal balloon inflatable to a size which fills a substantial portion of an anatomical lumen comprising muscular tissue;a proximal balloon inflatable to a size which fills a substantial portion of an anatomical lumen comprising muscular tissue;at least one intermediate balloon positioned between the distal balloon and the proximal balloon, the at least one intermediate balloon being inflatable independently from the distal and proximal balloons, wherein the anatomical lumen is selected from the group consisting of the esophagus, the rectum, the large intestine, the cardia and the small intestine; anda source lumen adapted and configured to receive a radiation source, the source lumen positioned within at least the one intermediate balloon;wherein at least two of the balloons are inflated and at least one intermediate balloon is deflated, said at least one intermediate balloon having a diameter that is different from the diameter of said inflated at least two of the balloons whereby varying inflation diameters create a predetermined shape to which the anatomical lumen tends to conform.15. The apparatus of claim 14 , further comprising a radiation source positioned within said source lumen claim 14 , said radiation source being positioned within said intermediate balloon claim 14 ,wherein the distal and proximal balloons are each independently inflatable and the intermediate balloon has a diameter smaller than the proximal ...

Multi-lumen fluted balloon radiation centering catheter

A multi-lumen balloon for use in a fluted balloon centering catheter and method for providing the same. The multi-lumen balloon maintains a radiation source at the center of a cardiovascular artery, has improved blood perfusion capability, and has improved balloon refolding characteristics. The method of fabricating a multi-lumen balloon designed for a radiation centering catheter uses an improved extrusion process that allows the manufacture of the multi-lumen balloon sub-assembly to be done separately from the catheter shaft assembly.

Device for implementing and monitoring endovascular brachytherapy

Device for implementing and monitoring endovascular brachytherapy Device for implementing endovascular brachytherapy, whereby in the region of the catheter tip, a beta or gamma radiator used to prevent restenosis after the removal of plaque from vessel walls emits radioactive radiation in order to suppress the structural vessel alteration, with simultaneous OCT-monitoring, whereby a brachytherapy is combined with an OCT catheter in an integrated unit.

Device for applying and monitoring of endovascular brachytherapy

Device for implementing endovascular brachytherapy, whereby in the region of the catheter tip, a beta or gamma radiator used to prevent restenosis after the removal of plaque from vessel walls emits radioactive radiation in order to suppress the structural vessel alteration, with simultaneous OCT-monitoring, whereby a brachytherapy is combined with an OCT catheter in an integrated unit.

Apparatus and method for treating constriction or other pinched condition in organic conduit

(57)【要約】 【課題】 従来のデバイスにおいては、操作性が悪かっ た。 【解決手段】 血管２６内における閉塞３０を処置する ためのデバイスであって、フレキシブルで長尺で中空の カテーテル１２と；うねり付バルーン１８と；カテーテ ル１２の外表面に沿って延在している導管２０と；うね り付バルーン１８を膨らませるための膨張源と；を具備 し、うねり付バルーン１８は、膨らまされたときに、一 対の突出部を形成し、突出部の各々は、うねり付バルー ン１８の長さ全体にわたって延在しており、突出部は、 バルーン１８が膨らまされたときに、長さ方向溝を通っ ての突出部回りの液体流通を可能とした状態で、処置の ために、および生体内の血管２６内におけるカテーテル １２のセンタリングのために、閉塞または締付部位に対 して接触している。

Catheter-assisted tumor treatment

A method for treating a subject diagnosed with a cancer or other disorder comprising a hyperproliferative tissue is described herein. The method includes localized delivery of a material which contains a therapeutically effective agent and/or moiety. The localized delivery of the agent is achieved using a catheter-based delivery system and an implant. An implant can include a support component, a cover component, and a valve component. The valve component can be operable to permit flow through the implant. The implant can be delivered on a catheter, with one of the ends of the implant being selectively expanded to permit temporary occlusion of a vessel while delivering a material through the valve component to a downstream target region. The other end of the implant can thereafter be released such that the implant occludes the vessel, or the implant can be removed from the vessel entirely.

Asymmetrical irradiation of a body cavity

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

Flexible multi-lumen brachytherapy device

A flexible, multi-lumen brachytherapy device includes a plurality of loose lumens extend through a hub towards a single point of attachment at a distal rigid section. Because the lumens are attached at only a single distal location, the lumens are free to move axially and rotatably, thereby increasing the overall flexibility of the device to thereby decrease intermittent device movement while increasing patient comfort. A novel keyed stylet can be selectively inserted to increase the rigidity of the device as needed. The ability to dynamically modify the rigidity of the brachytherapy device provides a comprehensive brachytherapy solution that satisfies concerns of the patient, the surgeon and the radiologists.

Using a guide member to facilitate brachytherapy device swap

A guide member facilitates a device swap for brachytherapy treatment. A cavity evaluation device is introduced during surgery such that a distal end of the device is disposed in a resected cavity of the patient. The cavity evaluation device includes a shaft in which is disposed an elongated guide member. In a subsequent out-patient procedure the cavity evaluation device is removed from the resected cavity. If a brachytherapy treatment is to be performed then the cavity evaluation device is removed without removing the elongated guide member such that position of a portion of the elongated guide member in the resected cavity is maintained relative to the resected cavity. An anchor member helps to maintain the position of the guide member. Introduction of a brachytherapy catheter is then facilitated by introducing the elongated guide member into an opening of the brachytherapy catheter and using the elongated guide member to guide the brachytherapy catheter to the resected cavity.

Intravascular catheter device and method for simultaneous local delivery of radiation and a therapeutic substance

Methods and devices for providing intravascular local radiation therapy and simultaneous local delivery of a solution of a therapeutic substance are disclosed. The therapeutic substance may be an antiplatelet substance, an antithrombotic substance, a thrombolytic substance, or a mixture thereof, among other possibilities. An exemplary balloon catheter assembly for delivery of the simultaneous radiation and therapeutic substance treatments includes an elongate body with lumen for delivering the solution of the therapeutic substance to a permeable inflation region at a distal end of the body, and a centerable delivery lumen for transporting a radiation source to the treatment site.

Combination ionizing radiation and immunomodulator delivery devices and methods for inhibiting hyperplasia

The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled immunomodulator delivery in combination with ionizing radiation to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and immunomodulator delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an ionizing radiation source coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, barrier, coating, infusion lumen, stent, graft, or reservoir for releasing an immunomodulator to the body lumen.

Multi-purpose catheters, catheter systems, and radiation treatment

Tis invention is new apparatuses and methods for treatments to be used from inside conduits or biological pathways. Examples of the biological pathways in which these new apparatuses and methods may be used include arteries, veins, and respiratory ways. Multi-purpose catheters (10) and catheter systems using structures including wires (2108), balloons (2150), and cords (2204) are described as well as methods to use such catheters and catheter systems. One of the embodiments is a configurable wire system which carries or transports radioactive sources. The wire is used in conjunction with a closed-end channel catheter.

An esophagus applicator for brachytherapy

The invention relates to an esophagus applicator for brachy therapy, comprising a molded plastic body comprising a proximal portion and a distal portion, said body accommodating a plurality of conduits, wherein at least one conduit from the said plurality of conduits is adapted to accommodate a displaceable radioactive source, and a further conduit from the said plurality of conduits is arranged to accommodate a guidewire, said proximal portion being connectable to an after loader device, said distal portion being substantially cone-shaped.

Dual double balloon catheter

A dual double balloon catheter includes a catheter having a proximal end portion, a central portion and a distal end portion, and a secondary treatment balloon for a catheter. The catheter includes a plurality of lumens within the catheter extending from the proximal end portion, a plurality of inflatable balloons positioned in the central portion and a secondary treatment balloon communicatively associated with the distal end portion of the catheter, and the balloons and the secondary treatment balloon being communicatively connected with a corresponding one of the plurality of lumens to selectively inflate/deflate the corresponding inflatable balloon or to receive a radioactive dose or a therapeutic agent for a treatment.

Applicator for intraoperative radiotherapy

La invención se refiere a un aplicador (1) para radioterapia intraoperatoria con rayos X de baja energía, que comprende un cuerpo aplicador (5), una superficie exterior (4) con una superficie exterior periférica y un extremo distal (3), un dispositivo receptor (8) en un extremo proximal (2), con el que se puede unir el aplicador (1) a un dispositivo de radiación de rayos X (20), y un rebaje interior (9) con una abertura en el extremo proximal (2) en en el que se puede insertar una fuente de radiación de rayos X (30, 31). El aplicador (1) tiene una estructura sólida y porosa en su superficie exterior (4). La estructura porosa sólida forma una estructura de canal coherente permeable al aire que está conectada por conducción de aire al extremo proximal (2) del aplicador (1) y da a la superficie exterior (4) del aplicador (1) una forma rígida. (Traducción automática con Google Translate, sin valor legal) The invention refers to an applicator (1) for intraoperative radiotherapy with low energy X-rays, comprising an applicator body (5), an outer surface (4) with a peripheral outer surface and a distal end (3), a device receiver (8) at a proximal end (2), with which the applicator (1) can be attached to an X-ray radiation device (20), and an inner recess (9) with an opening at the proximal end ( 2) into which an X-ray radiation source (30, 31) can be inserted. The applicator (1) has a solid and porous structure on its outer surface (4). The solid porous structure forms a coherent air-permeable channel structure which is connected by air conduction to the proximal end (2) of the applicator (1) and gives the outer surface (4) of the applicator (1) a rigid shape. (Automatic translation with Google Translate, without legal value)

Radiation catheter with multilayered balloon

The disclosure is directed to catheter devices and methods for controlled application of irradiation to tissue adjacent a body site, such as cavity after removal of tissue, e.g. cancer. The catheter device includes an inflatable balloon having at least two layers. The inflatable balloon has an expansion of more than 25% and less than 200% when inflated from the un-inflated condition to a turgid condition, preferably more than 50% and less than 150%. In the turgid condition the polymeric material(s) of the balloon layers are at or near the elastic limit of the balloon layer material. The balloon may contain or be formed of or be coated with radiopaque material to facilitate positional or symmetry verification.

Radiation delivery catheter with a spring wire centering mechanism

The invention is directed to a radiation delivery catheter assembly having blood perfusion capability suitable for maintaining patency of a body lumen for a period of time sufficient to allow delivery of a radiation source to the body lumen. The catheter assembly includes a spring wire centering mechanism which can be deployed between a retracted and expanded position. In the expanded position, the spring wire centering mechanism contacts a portion of the body lumen and centers a radiation source within the body lumen. In one particular embodiment, movable structural elements (spring wire legs) contact and center the adjacent portion of the catheter body within the body lumen when placed in the expanded position. In the retracted position, the spring wire mechanism is collapsed to a small profile to enable the catheter assembly to reach small diameter body lumens, such as distal coronary arteries. The spring wire centering mechanism is deployed between the retracted and expanded positions utilizing a retractable sheath which extends over the catheter body in a coaxial arrangement. This retractable sheath is movable along the length of the elongated catheter body and is designed to cover the spring wire centering mechanism to maintain it in the retracted position until the mechanism is to be deployed within the body lumen. When the retractable sheath is retracted to expose the spring wire centering mechanism, the resiliency of the spring wire legs moves the mechanism back to the expanded position.

Medical appliances for the treatment of blood vessels by means of ionizing radiation

A kind of modularization can swollen formula intracavitary therapy utensil

本发明提供一种模块化可膨式腔内放射治疗器具，至少包括：器具本体，器具本体内部设置有引流通道、气囊以及气囊充入通道，气囊充入通道连通于气囊；器具本体上还设置有可拆卸粒子条插入仓，用于放置可拆卸粒子条，可拆卸粒子条用于装载放射性粒子。当气囊膨胀时，膨胀的气囊会推挤放置在插入仓内的可拆卸粒子条向外周扩张，以使得在肿瘤缩小时，粒子条能够顺应贴附于瘤体。在无/微创操作条件下将本器具置入人体腔道内，以实现肿瘤的体内放射治疗；同时能够直接按需拆卸或添加某一根粒子条并调整其内部粒子数目及位置来优化放射性粒子的射线剂量分布，而不必将整个器具整体拔出，优化了治疗步骤并大大减少了患者在治疗过程中的不适感。

METHOD AND APPARATUS FOR TREATMENT OF STENOSIS OR OTHER CONSTRUCTION IN A BODY CONDUCT.

APARATO Y METODO PARA EL TRATAMIENTO DE UNA OCLUSION O CONSTRICCION, COMO UNA ESTENOSIS EN UN VASO SANGUINEO U OTRO CONDUCTO DEL ORGANISMO, ASI COMO UN APARATO Y UN METODO PARA EL TRATAMIENTO DE UNA SUPERFICIE TUMORAL O CANCEROSA QUE APARECE ALREDEDOR DE UN CONDUCTO DEL ORGANISMO. EL APARATO CONSISTE EN UN CATETER DOTADO DE UN BALON RABAT QUE RODEA UNA PARTE PROXIMA A SU EXTREMO DISTAL. CUANDO SE INTRODUCE EN EL ORGANISMO A LO LARGO DE UNA GUIA METALICA Y SE TRANSPORTA HASTA EL LUGAR DE LA ESTENOSIS, SE INFLA EL BALON UNA O MAS VECES Y, DEBIDO AL BALON ACANALADO, LA SANGRE PERFUNDE ALREDEDOR DEL CATETER DURANTE EL TRATAMIENTO. SE INTRODUCE UNA FUENTE DE MATERIAL RADIACTIVO A TRAVES DEL CATETER HASTA EL LUGAR DE LA ESTENOSIS O EL CANCER DONDE SE MANTIENE DURANTE UN PERIODO DE TIEMPO PARA REDUCIR LA APARICION DE REESTENOSIS O CANCER. PUEDE UTILIZARSE UNA GUIA METALICA DOTADA DE UNA PARTE CENTRAL EXTRAIBLE PARA DIRIGIR ADECUADAMENTE EL CATETER HASTA LA LOCALIZACION DE LA ESTENOSIS O EL CANCER. APPARATUS AND METHOD FOR THE TREATMENT OF AN OCLUSION OR CONSTRUCTION, AS A STENOSIS IN A BLOOD VESSEL OR ANOTHER BODY OF THE ORGANISM, AS WELL AS AN APPLIANCE AND A METHOD FOR THE TREATMENT OF A TUMOR OR CANCEROSA SURFACE THAT APPEARS AROUND A CONDUCT OR. THE APPLIANCE CONSISTS OF A CATHETER EQUIPPED WITH A RABAT BALL THAT IS SURROUNDING A PART NEXT TO ITS DISTAL END. WHEN IT IS INTRODUCED IN THE ORGANISM THROUGH A METAL GUIDE AND TRANSPORTATION UNTIL THE PLACE OF THE ESTENOSIS, THE BALL IS INFLATED ONE OR MORE TIMES AND, DUE TO THE ROLLED BALL, THE BLOOD IS ABOUT THE CATHETER DURING THE TREATMENT. A SOURCE OF RADIOACTIVE MATERIAL IS INTRODUCED THROUGH THE CATHETER UNTIL THE PLACE OF THE STENOSIS OR THE CANCER WHERE IT IS MAINTAINED DURING A TIME PERIOD TO REDUCE THE APPEARANCE OF RESET OR CANCER. A METAL GUIDE GIVEN WITH AN EXTRAIBLE CENTRAL PART CAN BE USED TO ADDRESS THE CATHETER PROPERLY TO THE LOCATION OF THE ESTENOSIS OR THE CANCER.

Method and apparatus for radiotherapy of a desired area in a patient's vascular system

(57)【要約】 例えば、バルーン血管形成術の実施に続いて起こる再狭窄の際に生じる場合のある瘢痕組織の形成を防止するために、治療用要素、例えば放射線源をカテーテルを通して患者の管腔内通路、例えば冠状動脈中の所望の部位まで送るための装置及び方法に関する。この装置は、基端部及び末端部を備えると共に内腔がこれら端部間に延びており、直径が患者の管腔内通路に挿入できるほど小さな細長い可撓性のカテーテル管を有する。一又は二以上の治療用要素、例えば放射性物質の入ったカプセル又はペレットが、内腔中に位置決め可能であり、内腔を通って流れる液体の力を受けて基端部と末端部との間で移動できる。かかる装置を用いる方法が開示されているが、この方法は、バルーン血管形成術の実施と同時にかかる装置を用いる方法を含む。

X-ray catheter

A catheter for emitting radiation is disclosed, comprising a catheter shaft (104), and an x-ray unit (102) attached to the distal end of the catheter shaft. The x-ray unit comprises an anode (112), and a cathode (110) coupled to an insulator (108) to define a vacuum chamber (106). The cathode is preferably a field emission cathode of graphite or graphite coated with titanium carbide, for example. The anode is preferably tungsten, and the insulator is preferably pyrolytic boron nitride. The x-ray unit is preferably coupled to a voltage source through a coaxial cable. The anode is preferably a heavy metal such as tungsten. The cathode may also be a ferroelectric material. The x-ray unit can have a diameter less than about 4mm, and a length less than about 15 mm. Methods of use of the catheter are also disclosed. The catheter of the present invention can be used to irradiate the site of an angioplasty procedure to prevent restenosis. It can also be used to treat other conditions in any vessel, lumen or cavity of the body.

Method and apparatus for uniform radiation treatment of vascular lumens

A method and apparatus for intravascular radiotherapy for prevention of stenosis following angioplasty or other trauma to coronary arteries caused by smooth muscle cell hyperplasia in which a uniform dosage of radiation is delivered to the walls of the artery by positively positioning a radioactive source at the radial center of the artery being treated.

Irradiation catheter and method of use

A catheter for use with a radioactive source within the catheter to irradiate a selected area of a blood vessel in combination with angioplasty procedures, to prevent restenosis of that area of the blood vessel. The catheter has a guidewire channel formed near its distal end to facilitate use of the catheter as a rapid exchange catheter, allowing insertion of the catheter over a guidewire also used in performance of an angioplasty procedure. The catheter also has a radiation lumen with a sealed end to retain the radioactive source within the catheter. The radiation lumen is sufficiently longer than the guidewire channel to extend into a non-sterile field, keeping the radiation source segregated from the blood, allowing the use of a non-sterile radiation source. The catheter can also be provided with a centering balloon or a set of centering wire loops to center the radioactive source radially within the blood vessel.

Positioning catheter for intravascular irradiation of coronary and peripheral vessels with radioactive rays

Positionierungskatheter (1) zur Einführung und Positionierung eines Applikationskatheters (11) in einem Gefäß eines Patienten, wobei der Positionierungskatheter (1) einen distalen Abschnitt (5), der zur Aufnahme eines distalen Endes des Applikationskatheters (11) eingerichtet ist, und eine Struktur aufweist, die einen Abstand zwischen dem in den Positionierungskatheter (1) eingeführten Applikationskatheter (11) und der Innenwand des Gefäßes bewirkt, wobei der Positionierungskatheter (1) in einem Hüllkatheter (15) angeordnet ist, in den der distale Abschnitt (5) des Positionierungskatheters (1) zurückgezogen werden kann, wobei er in eine komprimierte Form gebracht wird, in der sein radialer Durchmesser reduziert ist, und der Applikationskatheter (11) ein Ballonkatheter ist. A positioning catheter (1) for introducing and positioning an application catheter (11) in a patient's vessel, the positioning catheter (1) having a distal portion (5) adapted to receive a distal end of the delivery catheter (11) and a structure which causes a distance between the application catheter (11) inserted into the positioning catheter (1) and the inner wall of the vessel, wherein the positioning catheter (1) is arranged in an enveloping catheter (15) into which the distal section (5) of the positioning catheter (15) 1), being brought into a compressed form in which its radial diameter is reduced, and the application catheter (11) is a balloon catheter.

Radiation centering catheters

The invention is directed to a radiation delivery catheter assembly for maintaining patency of a body lumen for a period of time sufficient to allow delivery of a radiation source to the body lumen. The catheter utilizes an inflatable region which maintains and centers the catheter in the body lumen. The catheter may include a perfusion lumen for supplying oxygenated blood to tissue located downstream from the catheter when the inflatable region is expanded in the body lumen. The inflatable region can be made up of a plurality of balloon segments which help center the radiation source, even if placed on a curved section of the body lumen. Embodiments of the invention include a catheter design which utilizes 'rapid exchange' features and a dual therapeutic catheter which is capable of dilating a stenosed region of the body lumen prior to the administration of the radiation treatment. A two-piece protective sheath is used to protect the radiation source from bodily fluids.

Intravascular radiation delivery system

This invention is an intravascular radiation delivery system (10) including a catheter (11), a radiation source (14), disposed in an open-ended lumen (12) in the catheter (11), and a closed-ended sheath (13) surrounding the radiation source (14), so as to prevent blood and other fluids from coming into contact with the radiation source (14). Preferably, the open-ended lumen (12) is centered in the balloon (15) for uniform radiation delivery. The catheter (11) may include a blood perfusion lumen under the balloon (15) or around the balloon (15). The open-ended lumen (12) in the catheter (11) may have a reduced diameter adjacent the distal end of the catheter (11) to prevent the radiation source (14) from exiting the lumen. Methods of using the radiation delivery system (10) are also disclosed, such as an alternative method of delivering radiation to a treatment site inside the vasculature of a patient using a gas-filled balloon catheter and a radiation source disposed in the balloon catheter. The treatment site is exposed to radiation, preferably beta radiation, through the gas-filled balloon.

Medical appliances for the treatment of blood vessels by means of ionizing radiation

A catheter with a balloon mounted coaxially thereon, and a radiation emitting source disposed and essentially centered in the catheter distal portion.

Flexible Multi-Lumen Brachytherapy Device

A flexible, multi-lumen brachytherapy device includes a plurality of loose lumens extend through a hub towards a single point of attachment at a distal rigid section. Because the lumens are attached at only a single distal location, the lumens are free to move axially and rotatably, thereby increasing the overall flexibility of the device to thereby decrease intermittent device movement while increasing patient comfort. A novel keyed stylet can be selectively inserted to increase the rigidity of the device as needed. The ability to dynamically modify the rigidity of the brachytherapy device provides a comprehensive brachytherapy solution that satisfies concerns of the patient, the surgeon and the radiologists.

DILATION / CENTERING CATHETER.

UN APARATO PARA TRATAR UNA OCLUSION O CONSTRICCION, COMO POR EJEMPLO UNA ESTENOSIS EN UN VASO U OTRO CONDUCTO SANGUINEO CORPORAL PARA TRATAR UN TUMOR O AREA CANCEROSA ALREDEDOR DE UN CONDUCTO CORPORAL. EL APARATO COMPRENDE UN CATETER (10) DOTADO DE UN BALON (41) DE CENTRADO DEL CATETER QUE RODEA UNA PARTE DEL CATETER PROXIMO A SU EXTREMO DISTAL. DICHO BALON DE CENTRADO CONTIENE UNA PLURALIDAD DE MIEMBROS (44, 46, 48, 50) EN FORMA DE RADIOS. UN SEGUNDO BALON (14) DE DILATACION FIJADO A LA SUPERFICIE DEL CATETER SE UTILIZA PARA TRATAR EL AREA CON ESTENOSIS. UNA FUENTE DE MATERIAL (28) RADIOACTIVO PODRA INCLUIRSE PARA TRATAR LA ESTENOSIS O EL CANCER. AN APPLIANCE TO TREAT AN OCLUSION OR CONSTRICTION, AS FOR EXAMPLE A STENOSIS IN A VESSEL OR OTHER BODY BLOOD DUCT TO TREAT A CANCER TUMOR OR AREA AROUND A BODY DUCT. THE APPLIANCE INCLUDES A CATETER (10) EQUIPPED WITH A BALL (41) OF CENTER OF THE CATETER THAT SURROUNDS A PART OF THE CATHETER NEXT TO ITS DISTAL END. SUCH CENTERING BALL CONTAINS A PLURALITY OF MEMBERS (44, 46, 48, 50) IN THE FORM OF RADIOS. A SECOND BALL (14) OF DILATATION FIXED TO THE SURFACE OF THE CATETER IS USED TO TREAT THE AREA WITH ESTENOSIS. A SOURCE OF RADIOACTIVE MATERIAL (28) MAY BE INCLUDED TO TREAT STENOSIS OR CANCER.

Light generating device to intravascular use

Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

Rapid exchange catheter

A novel over the wire-rapid exchange catheter is provided comprising a novel proximal end, which works in conjunction with the distal end of a traditional rapid exchange catheter, having a particular arrangement as shown in FIG. 1 which serves to enhance the users ability to properly operate and maneuver the guidewire/catheter, and thus to more effectively carry out the catherization procedure. Additionally, an OTW-RE catheter is provided with a means for rapidly removing the guidewire from the proximal end of the catheter, at the appropriate time during the procedure, while preserving the integrity of the device.

Carbon dioxide inflated radio-therapy balloon catheter

Multitube esophageal brachytherapy catheter

Guided cardiac ablation catheters

Guided ablation instruments are disclosed for creating lesions in tissue, especially cardiac tissue for treatment of arrhythmias, including atrial fibrillation. In one aspect of the invention, a percutaneous catheter is disclosed with an endoscope positionable in the instrument's distal end region to obtain an image. The image allows the clinician to determine whether contact has been achieved (or blood has been cleared from an ablative energy transmission path) before ablation begins or while ablation is occurring. In one embodiment, percutaneous ablation catheters are disclosed having at least one central lumen and one or more balloon structures at the distal end region of the instrument. Also disposed in the distal end region are an illuminating light source and an endoscope capable of collecting sufficient light to relay an image to the user. The instruments can further include an ablation element. The ablation element can be a contact ablation element, or a radiant energy emitter, which is preferably independently positionable within the lumen of the instrument and adapted to project ablative energy through a transmissive region of the instrument body (and/or balloon) to a target tissue site proximate to the pulmonary veins. The energy can delivered without the need for contact between the energy emitter and the target tissue so long as a clear transmission pathway is established. The endoscope element of the instrument allows the clinician to determine the position of the instrument and, if radiant energy is to be employed, see if such a pathway is clear. Moreover, because the position of the radiant energy emitter can be varied, endoscopic guidance permits the clinician to select a desired location and dose for the lesion.

Radiation treatment of the vascular system

Apparatus for delivery of a treatment element (22) such as a radiation source, through a catheter (92) to a desired site in the interluminal passageways of a patient, such as the coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. One or more treatment elements (22), such as a capsule or pellet containing radioactive material, is positionable within the lumen (144) and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. Balloon membrane (256) can be used for angioplasty.

Dosimetry implant for treating restenosis and hyperplasia

The present invention discloses a method of selectively providing radiation dosimetry to a subject in need of such treatment. The radiation is applied by an implant comprising a body member and 117m Sn electroplated at selected locations of the body member, emitting conversion electrons absorbed immediately adjacent selected locations while not affecting surrounding tissue outside of the immediately adjacent area.

Dilatation/centering catheter for the treatment of stenosis

A modular applicator for brachytherapy.

The invention relates to a modular applicator (15) for enabling a brachytherapy treatment, comprising a central core (8) and an outer sleeve (9), wherein the central core is adapted with a fixation mechanism (8a) for affixing the outer sleeve to the central core, wherein the outer sleeve is manufactured from a substantially rigid or shapeable material.

Prepared catheter

(57)【要約】 【課題】 線源から膨張バルーンを通過した治療される べき脈管の部分までの移動中に、可能な限り小さい割合 の電離放射線が吸収されるカテーテルを提供する。 【解決手段】 カテーテルは、脈管部分への経皮的かつ 経腔的なアクセスとしての、基端部および先端部２を有 する細長いシャフト１と、シャフト１の先端部２に配置 される膨張可能なバルーン８と、シャフト１を貫通して 延びかつバルーン８内に開く膨張管腔７と、バルーン８ 内に位置決めされ得る電離放射線源１２とを有し、バル ーン８に圧力を加えるための膨張媒体９が充填される構 成とし、膨張媒体９を気体とする。

A modular applicator for brachytherapy

The invention relates to a modular applicator (15) for enabling a brachytherapy treatment, comprising a central core (8) and an outer sleeve (9), wherein the central core is adapted with a fixation mechanism (8a) for affixing the outer sleeve to the central core, wherein the outer sleeve is manufactured from a substantially rigid or shapeable material.

Radiation catheter with multilayered balloon

本公开涉及用来可控地对邻近身体部位(例如，去除诸如癌的组织之后留下的腔体)的组织进行照射的导管装置和方法。导管装置包括具有至少两层的可充气气囊。当从未充气状态充气至膨胀状态时，可充气气囊具有大于25％但小于200％的膨胀，该膨胀优选地大于50％但小于150％。在膨胀状态下，气囊层的聚合材料处于或接近于气囊层材料的弹性极限。气囊可包含不透射线的材料，或可由不透射线的材料制成，或涂覆有不透射线的材料，以便进行定位确认或对称性确认。

Combination x-ray radiation and drug delivery devices and methods for inhibiting hyperplasia

The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled drug delivery in combination with x-ray radiation delivery to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and agent delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an x-ray tube coupleable to the catheter body for applying a radiation dose to a body lumen, and means coupleable to the catheter body for releasing an agent to the body lumen.

Medical apparatus for the treatment of blood vessels by means of ionizing radiation

Brachytherapy devices and methods for therapeutic radiation procedures.

Los dispositivos, sistemas y métodos de radioterapia o braquiterapia están en forma de catéter en general e incluyen al menos un componente expansible terapéutico que ayuda en la colocación de elementos terapéuticos de radio en los lugares de tratamiento deseados dentro de una cavidad corporal existente o en un sitio que se formó bajo la piel de un paciente para los propósitos de tratamiento. Uno o más detectores, tales como microdiodos, están presentes en el dispositivo, y un tubo de hipertermia o similares también se incluye, que entrega tratamiento de hipertermia para el sitio o sitios de tratamiento objetivo. Los datos recogidos por el detector permiten al profesional médico para controlar el tratamiento de radiación y, cuando se desee, la interacción y entre tratamiento de hipertermia y la entrega de radiación por el elemento de tratamiento de radiación.

Light generating device that self centers within a lumen to render photodynamic therapy

A light generating device (1) for illuminating tissue adjacent to a body lumen while a distal end (5) of the device is centered in the lumen, to render photodynamic therapy. The device can either occlude or displace bodily fluid, both without the use of a balloon. In one embodiment, a flushing lumen (4B) has a port adjacent to an array of light sources(10) , to displace bodily fluid that might otherwise absorb light. Another embodiment employs a centering (45) member that moves between a first position and a second position. The centering member centers the device in the lumen and preferably is formed of a shape memory material. In yet another embodiment, the device includes an outer sheath and an inner member that are independently positionable, enabling the centering member to be selectively positionable. The centering member can be non porous, such that the centering member also occludes fluid flow.

System and method for high dose rate radiation intracavitary brachytherapy

The apparatus, method and system for performing a high dose rate brachytherapy procedure in a body cavity may include an at least partially indwelling multi-lumen catheter with a plurality of inflatable balloons coupled thereto. A lumen may be adapted to receive radiation seeds. The balloons, when inflated, may be adapted to administer a substantially uniform radiation isodose to the body cavity. Some embodiments may be well suited to performing intrauterine brachytherapy for the treatment of endometrial carcinoma.

Perfusion balloon and radioactive wire delivery system

This invention is a catheter (320) capable of irradiating blood vessel walls to inhibit restenosis after angioplasty. Catheters (320) are capable of simultaneous irradiation, angioplasty, and in some devices drug infusion. Preferred catheters (320) include a helical perfusion balloon (336) having strand windings (346) spaced apart when inflated, and defining a perfusion lumen (356) within. A tubular sheath (374) over the helical strands (346), and distal shaft region (326) is used in some embodiments and defines an outer wall for the perfusion lumen (356). A spiral, inter-strand space (376) is defined between the sheath outer wall, and the blood vessel inner wall providing a confined volume for controlled delivery of drugs to the vessel wall in conjunction with irradiation. A device having a radiation wire distally closed end tube is provided. A device having a radiation wire open ended tube terminating proximally of the perfusion lumen is also provided.

Energy filtering system

An energy filtering system (42) including an energy filtering material (42) provided between a radioactive material (20) and a treatment target (10) such that radioactive energy is filtered.

Medical appliance for the treatment of a portion of the body vessel by ionizing radiation