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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 427. Отображено 174.
24-03-2005 дата публикации

Tissue site markers for in vivo imaging

Номер: US20050063908A1
Автор: Fred Burbank, Paul Lubock, Michael Jones, Richard Quick, Frank Louw, Stephen De Santis
Принадлежит: SenoRX, Inc.

The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site ...

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Номер записи: 1
28-06-2016 дата публикации

Biopsy system with integrated imaging

Номер: US0009375204B2
Автор: Lloyd H. Malchow, Paul Lubock, Derek Daw, MALCHOW LLOYD H, LUBOCK PAUL, DAW DEREK, MALCHOW LLOYD H.
Принадлежит: SENORX, INC., SENORX INC

A structurally integrated biopsy system includes a movable base having wheels to facilitate movement of the structurally integrated biopsy system. On the movable based there is mounted a tissue removal system, an ultrasound imaging system, and a controller. The tissue removal system includes a probe connector configured to connect to a tissue removal probe. The ultrasound imaging system is configured to generate an ultrasound image of a body region of a patient, and has an image display system having an image display screen to display ultrasound images taken by the ultrasound imaging system. The controller is configured to be in communication with each of the tissue removal system and the ultrasound imaging system to both provide control information for the ultrasound imaging system and provide control information for the tissue removal system in the structurally integrated biopsy system.

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Номер записи: 2
16-08-2001 дата публикации

Electrosurgical biopsy device and method

Номер: US20010014779A1
Автор: Fred Burbank, Paul Lubock, Michael Jones, Richard Quick
Принадлежит: SenoRx, Inc.

An electrosurgical biopsy device includes a stylet and a cannula movably mounted on a base. The stylet has a shaft with a head at its distal end and a stylet ablation element extending distally from the head. The stylet shaft is disposed through the cannula for axial translation therein between withdrawn and extended positions. The cannula has an opening at its distal end and a cannula ablation element adjacent the opening. Both ablation elements are activatable with energy that ablates adjacent tissue. A translation mechanism controllably moves (a) the stylet between the withdrawn and extended positions and (b) the cannula between a proximal position and a distal position relative to the base. In use, with the stylet in the withdrawn position against the distal end of the cannula, and with the stylet ablation element activated, the stylet and the cannula are pushed through the skin and the underlying tissue until the stylet head is adjacent a targeted tissue mass. Next, the stylet is extended ...

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Номер записи: 3
15-02-2022 дата публикации

Biopsy device with aperture orientation and improved tip

Номер: US0011246574B2
Автор: Martin V. Shabaz, Richard L. Quick, Frank R. Louw, Paul Lubock, Jason H. Safabash
Принадлежит: SenoRx, Inc.

A biopsy device includes an elongated probe having a central longitudinal axis, a proximal end, and a distal end. A tissue penetrating tip includes a proximal base and a sharp distal point. The proximal base is secured to the distal end of the elongated probe. The sharp distal point is distal to the proximal base and is aligned with the central longitudinal axis. The tissue penetrating tip has a plurality of concave surfaces annularly arranged to form at least three adjacent pairs of concave surfaces. Each concave surface of the plurality of concave surfaces extends from the proximal base to the sharp distal point. Each adjacent pair of concave surfaces intersect to form a concave curved cutting edge. Cumulatively, the at least three adjacent pairs of concave surfaces form a plurality of concave curved cutting edges that distally terminate at the sharp distal point.

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Номер записи: 4
06-10-2015 дата публикации

Deployment of polysaccharide markers for treating a site within a patient

Номер: US0009149341B2
Автор: Michael L. Jones, Paul Lubock, JONES MICHAEL L, LUBOCK PAUL, JONES MICHAEL L.
Принадлежит: SenoRx, Inc, JONES MICHAEL L, LUBOCK PAUL, SENORX INC, JONES MICHAEL L., SENORX, INC

A method for treating a site within a patient from which tissue has been removed includes providing at least one press-formed marker body formed of polysaccharide and a suitable binder; and placing the at least one of the press-formed marker body within the site where tissue has been removed so as to provide hemostasis therein.

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Номер записи: 5
06-01-2005 дата публикации

Breast biopsy system and methods

Номер: US20050004492A1
Автор: Fred Burbank, Michael Jones, Paul Lubock
Принадлежит: SenoRx, Inc.

An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possibly cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument having a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding ...

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Номер записи: 6
29-05-2008 дата публикации

MRI imageable assembly

Номер: US20080125644A1
Автор: Paul Lubock, Richard L. Quick, Ethan Broadaway
Принадлежит: SenoRx, Inc.

A marker delivery device is described which has an obturator with an elongated shaft, an inner lumen, a proximal end, and a substantially sealed distal end. One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker(s) is disposed within an inner lumen of a marker delivery tube which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.

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Номер записи: 7
13-09-2018 дата публикации

DEVICE AND METHOD FOR TREATING VASCULAR OCCLUSION

Номер: US20180256178A1
Автор: Brian J. Cox, Paul Lubock, Robert F. Rosenbluth, COX BRIAN J, LUBOCK PAUL, ROSENBLUTH ROBERT F, Cox, Brian J., Lubock, Paul, Rosenbluth, Robert F.
Принадлежит:

A system and method for managing an occlusion, such as a blood clot, within a lumen or passageway of a patient. More particularly, a system and method for rapidly restoring blood flow through an occlusion including a self-expanding, tubular member through which blood may flow when in an expanded state. The tubular member has a structure configured to engage the occlusive material, thereby allowing for extraction of at least a portion of the occlusive material. The system may further employ a material extraction member that is deployed distally of the tubular member. 1. A method of treating deep vein thrombosis in a peripheral vasculature of a patient , the method comprising:percutaneously accessing a venous vessel of a patient;positioning a thrombus extraction device in a lumen of a catheter proximate to a vascular thrombus in the venous vessel, wherein the thrombus extraction device comprises an expandable tubular mesh having first end and a second end, the first end defining a self-expanding mouth;deploying the thrombus extraction device from the catheter;affecting an orientation of the self-expanding mouth of the tubular mesh via manipulation of at least one tether coupled to the self-expanding mouth of the tubular mesh;capturing thrombus within the expandable tubular mesh; andretracting the expandable tubular mesh from the venous vessel.2. The method of claim 1 , wherein the thrombus extraction device further comprises an elongate retraction member coupled to the at least one tether claim 1 , and wherein manipulation of the retraction member manipulates the at least one tether.3. The method of claim 2 , wherein the retraction member is at least partially positioned within the lumen of the catheter claim 2 , and wherein manipulation of the retraction member comprises displacement of the retraction member within the lumen of the catheter with respect to the catheter.4. The method of claim 2 , wherein the thrombus extraction device further comprises a connector ...

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Номер записи: 8
15-11-2011 дата публикации

Treatment of a body cavity

Номер: US0008057379B2
Автор: Paul Lubock, Michael L. Jones, LUBOCK PAUL, JONES MICHAEL L, JONES MICHAEL L.
Принадлежит: Senorx, Inc., LUBOCK PAUL, JONES MICHAEL L, SENORX INC, JONES MICHAEL L., SENORX, INC.

Devices and methods are provided for controlled application of a treatment to tissue adjacent a body cavity, such as after removal of tissue, e.g. cancer. A device embodying features of the invention includes one or more radiation shielding components to control emitted radiation from a radiation source to minimize radiation damage to healthy portions of the body cavity. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location therein to seal the passageway leading to the body cavity. Methods for treating a body cavity include methods for delivering a radiation source to a body cavity while minimizing damaging irradiation of healthy tissue.

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Номер записи: 9
20-04-2004 дата публикации

Tissue site markers for in VIVO imaging

Номер: US0006725083B1
Автор: Fred H. Burbank, Paul Lubock, Michael L. Jones, Richard L. Quick, Frank Louw, Stephen A. De Santis, BURBANK FRED H, LUBOCK PAUL, JONES MICHAEL L, QUICK RICHARD L, LOUW FRANK, DE SANTIS STEPHEN A, BURBANK FRED H., JONES MICHAEL L., QUICK RICHARD L., DE SANTIS STEPHEN A.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

The invention is directed to biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy ...

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Номер записи: 10
19-10-2023 дата публикации

DEVICES AND METHODS FOR TREATING VASCULAR OCCLUSION

Номер: US20230329734A1
Автор: Phil Marchand, Benjamin E. Merritt, John C. Thress, Jacob F. Louw, Paul Lubock, Brian J. Cox
Принадлежит:

Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a fenestrated structure, a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter; retracting the self-expanding member to unstack the portion of the net-like filament mesh structure and to capture the portion of the thrombus; and withdrawing the thrombus extraction device from the body.

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Номер записи: 11
03-11-2005 дата публикации

Methods and apparatus for securing medical instruments to desired locations in a patient's body

Номер: US20050245842A1
Автор: Fred Burbank, Paul Lubock, Michael Jones, Richard Quick
Принадлежит: SenoRx, Inc.

Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

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Номер записи: 12
30-01-2003 дата публикации

Apparatus and method for accessing a body site

Номер: US20030023239A1
Автор: Fred Burbank, Paul Lubock, Martin Shabaz, Frank Louw
Принадлежит: SenoRx, Inc.

A device and method of using the device to access a desired tissue site within a patient's body and separating a tissue specimen from the tissue site suitable for evaluation. The device includes a probe member having an arcuate tissue-cutting RF powered electrode secured to and distally spaced from the distal end of the probe and a small dimensioned distal extremity which when an inner lumen thereof is subjected to a vacuum, secured tissue for the specimen to the surface of the distal extremity. A circular tissue-cutting blade preferably secured to the distal end of a supporting tube is configured to rotate and move longitudinally along the shaft of the probe member effective to sever a tissue specimen from tissue secured to the surface of the distal extremity of the probe member. The supporting tube covers the separated specimen, and may be disposed within an accessing cannula.

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Номер записи: 13
16-11-2017 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20170325839A1
Автор: Robert F. Rosenbluth, Brian J. Cox, Paul Lubock
Принадлежит:

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material. 1. A method of treating a pulmonary embolism comprising:identifying a pulmonary embolism at least partially restricting blood flow through a pulmonary artery;delivering an embolectomy device through the heart to said pulmonary embolism;deploying said embolectomy device within said pulmonary embolism so as to restore blood flow through said pulmonary embolism;said deploying comprising expanding said embolectomy device within said pulmonary embolism with at least a portion of said embolectomy device expanding distal to said pulmonary embolism;retracting said embolectomy device through said pulmonary embolism such that at least a portion of said pulmonary embolism is captured by said embolectomy device;said retracting comprising elongating said embolectomy device during said retracting;withdrawing said embolectomy device with said at least a portion of said pulmonary embolism.2. A method according to claim 1 , wherein said expanding of said embolectomy device comprises expanding a plurality of radial extensions of said embolectomy device.3. A method according to claim 2 , wherein at least one of said plurality of radial extensions is expanded distal to said pulmonary embolism.4. A method according to claim 1 , wherein said expanding of said embolectomy device comprises expanding a generally cylindrical portion of said device.5. A method according to claim 4 , wherein said expanding of said embolectomy device comprises expanding a plurality of radial extensions of a generally cylindrical embolectomy device.6. A method according to claim 1 , ...

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Номер записи: 14
07-07-2022 дата публикации

HEMOSTASIS VALVES AND METHODS OF USE

Номер: US20220211992A1
Автор: Benjamin E. Merritt, John C. Thress, Paul Lubock
Принадлежит:

Devices, systems, and methods for sealing medical devices, particularly during intravascular access, are disclosed herein. Some aspects relate to a hemostatic valve for sealing a wide range of medical devices, such as catheters, wires, embolectomy systems. The valve can include an elongate member having a first end, a second end, and a central lumen extending therebetween. A reinforcement structure extends along at least a portion of the elongate member and is coupled to the elongate member. A shell defining a first aperture and a second aperture may be included, which first and second apertures can be fluidly coupled by the elongate member. A tensioning mechanism is coupled to the shell and to the elongate member, the tensioning mechanism can be moveable between a first configuration wherein the tensioning mechanism is collapsed and the central lumen is sealed and a second configuration wherein the central lumen is open.

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Номер записи: 15
14-02-2008 дата публикации

Marker formed of starch or other suitable polysaccharide

Номер: US20080039819A1
Автор: Michael Jones, Paul Lubock
Принадлежит: SenoRx, Inc.

The marker member delivery system described has at least one marker member disposed within a delivery tube or cannula is formed at least in part of starch or a suitable polysaccharide. The marker member is preferably in the form of fibrous member.

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Номер записи: 16
24-01-2008 дата публикации

Electrosurgical lesion location device

Номер: US20080021449A1
Автор: Fred Burbank, Frank Louw, Paul Lubock, Richard Quick
Принадлежит: SenoRx, Inc.

A device for localizing a target tissue mass in a body includes a tubular trocar portion having a distal end and a proximal end portion that is removably attachable to a handle portion. The trocar portion contains at least a first plurality of locator wires that are movable between a retracted position within the trocar and a deployed position extending radially from the trocar. The first plurality of locator wires mounted for axial movement within the trocar portion between a proximal retracted position and a deployed distal position. The second plurality of locator wires is mounted for movement between a distal retracted position and a proximal deployed position. The locator wires are electrically energized to facilitate their deployment electrosurgically.

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Номер записи: 17
04-10-2012 дата публикации

CAVITY-FILLING BIOPSY SITE MARKERS

Номер: US20120253189A1
Автор: Fred H. Burbank, Paul Lubock, Michael L. Jones, BURBANK FRED H, LUBOCK PAUL, JONES MICHAEL L, BURBANK FRED H., JONES MICHAEL L.
Принадлежит: SenoxRx, Inc.

The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula. 1. A marking system for delivering a marker mass into a cavity in a patient , comprising:a delivery tube; andan ultrasound-detectable biopsy marker mass carried by the delivery tube for delivery to the cavity, the ultrasound-detectable biopsy marker mass having a detectable in-vivo lifetime during which the marker mass remains readily detectable by ultrasound, and which is formed of particles of a bio-resorbable material having internal bubble cavities and having a particle size less than about 800 microns.275-. (canceled)76. The marking system of claim 1 , wherein the marker mass is a bio-resorbable powder mass having a volume of between about 0.2 ml and about 1.2 ml of powder.77. The marking system of claim 1 , wherein the particle size is between about 200 microns and about 500 microns claim 1 , and the bubble cavities have a size of at least 50 microns claim 1 , wherein the bubble cavities have geometric centers and the bubble cavity size is measured by length through the geometric centers of the bubble cavities.78. The marking system of claim 1 , ...

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Номер записи: 18
30-09-2004 дата публикации

Tissue site markers for in vivo imaging

Номер: US20040193044A1
Автор: Fred Burbank, Paul Lubock, Michael Jones, Richard Quick, Frank Louw, Stephen De Santis
Принадлежит: SenoRx, Inc.

The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site ...

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Номер записи: 19
30-07-2013 дата публикации

Intracorporeal marker and marker delivery device

Номер: US0008498693B2
Автор: Michael L. Jones, Paul Lubock, John Merritt, JONES MICHAEL L, LUBOCK PAUL, MERRITT JOHN, JONES MICHAEL L.
Принадлежит: Senorx, Inc., JONES MICHAEL L, LUBOCK PAUL, MERRITT JOHN, SENORX INC, JONES MICHAEL L., SENORX, INC.

An elongated intracorporeal remotely detectable marker includes a core of bioabsorbable fibers. An outer jacket of bioabsorbable fibers is disposed around at least part of the core. In one embodiment, for example, the core has a longitudinal extent and a pair of opposed ends, and the outer jacket is disposed around the longitudinal extent of the core, with the pair of opposed ends being exposed.

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Номер записи: 20
15-07-2004 дата публикации

High frequency power source

Номер: US20040138653A1
Автор: James Dabney, Richard Quick, Conrad Sawicz, Paul Lubock, Dan Kussman
Принадлежит: SenoRx, Inc.

A high frequency electrosurgical power generator configured to produce electrical power at a frequency of about 1 to about 14 MHz and preferably having an essentially sinusoidal waveform with a voltage level up to 1,000 Vrms, and a current level up to 5 Amps. The output of the high frequency electrosurgical power generator is connected to an electrosurgical tool configured to receive the voltage and current produced by the electrosurgical power generator and deliver the voltage and current to an electrosurgical site. The output of the electrosurgical generator preferably is an essentially sinusoid waveform with a frequency between about 3 MHz and about 8 MHz, up to about 700 volts rms, up to about 2 amps, with a total power of up to 1,000 watts.

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Номер записи: 21
06-03-2008 дата публикации

Marker formed of starch or other suitable polysaccharide

Номер: US20080058640A1
Автор: Michael Jones, Paul Lubock
Принадлежит: SenoxRx, Inc.

The marker member delivery system described has at least one marker member disposed within a delivery tube or cannula is formed at least in part of starch or a suitable polysaccharide. The marker member is preferably in the form of fibrous member.

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Номер записи: 22
20-11-2014 дата публикации

EXPANDABLE OCCLUSION DEVICE AND METHODS

Номер: US20140343602A1
Автор: Brian J. Cox, Paul Lubock, Richard Quick, Robert Rosenbluth
Принадлежит:

An occlusion device and method for occluding an undesirable passage through tissue, such as a septal defect, that provides an expandable cylinder or other structure that occludes the passage internally or by covering one or more openings to the passage. The occlusion device includes a wire lattice or mesh that expands from a contracted catheter-deliverable state to an expanded state that occludes the passage. The lattice or mesh has one or more layers, with layers that provide structural support to the device, and layers that provide a lattice braiding or pore sizes that promote further occlusion by a biological process, such as tissue ingrowth that further occludes the affected passage. 1. A device for occluding a passage through cardiac or vascular tissue , the passage having opposing open ends , the device comprising:expandable proximal and distal occlusion members aligned with each other to define a common axis about which the occlusion members can expand, the proximal and distal occlusion members each configured to assume a low-profile contracted state that fits in an intravascular catheter and an expanded state configured to cover one of the opposing open ends of the passage, the proximal and distal occlusion members each having a center portion disposed about the axis and a peripheral portion extending from the center portion, the peripheral portion of each occlusion member configured to contact the tissue surrounding one of the opposing open ends of the passage in the expanded state, the center portion of each occlusion member having a proximal end and a distal end disposed such that the distal end of the proximal occlusion member faces the proximal end of the distal occlusion member;a proximal hub disposed at each of the proximal ends of the proximal and distal occlusion members;a distal hub disposed at each of the distal ends of the proximal and distal occlusion members; anda tether extending between the distal end of the proximal occlusion member and the ...

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Номер записи: 23
16-10-2018 дата публикации

Devices and methods for treating vascular occlusion

Номер: US0010098651B2
Автор: Phil Marchand, Benjamin E. Merritt, John C. Thress, Jacob F. Louw, Paul Lubock, Brian J. Cox, MARCHAND PHIL, MERRITT BENJAMIN E, THRESS JOHN C, LOUW JACOB F, LUBOCK PAUL, COX BRIAN J, Marchand, Phil, Merritt, Benjamin E., Thress, John C., Louw, Jacob F., Lubock, Paul, Cox, Brian J.
Принадлежит: Inari Medical, Inc., INARI MEDICAL INC

Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a fenestrated structure, a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter; retracting the self-expanding member to unstack the portion of the net-like filament mesh structure and to capture the portion of the thrombus; and withdrawing the thrombus extraction device from the body.

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Номер записи: 24
29-01-2013 дата публикации

Marker delivery device with releasable plug

Номер: US0008361082B2
Автор: Michael L. Jones, Paul Lubock, John Merritt, JONES MICHAEL L, LUBOCK PAUL, MERRITT JOHN, JONES MICHAEL L.
Принадлежит: Senorx, Inc., SENORX INC, JONES MICHAEL L, LUBOCK PAUL, MERRITT JOHN, SENORX, INC., JONES MICHAEL L.

A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body includes a plurality of bioabsorbable polymeric strands. The strands are compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula. A releasable plug is disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body so as to at least partially occlude the discharge opening in the distal end section.

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Номер записи: 25
11-12-2012 дата публикации

Temporary catheter for biopsy site tissue fixation

Номер: US0008328710B2
Автор: Paul Lubock, Michael L. Jones, LUBOCK PAUL, JONES MICHAEL L, JONES MICHAEL L.
Принадлежит: SENORX, Inc., LUBOCK PAUL, JONES MICHAEL L, SENORX INC, JONES MICHAEL L., SENORX, INC.

Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. One embodiment of the catheter device includes an elongated shaft having a proximal shaft section which is flexible enough to be folded or coiled into a configuration for deployment within the patient. An alternate embodiment includes a catheter device having one or more detachable proximal shaft sections and having at least one one-way valve to restrict fluid flow of inflation fluid to flow to the balloon. After deployment of the catheter device completely within the patient, the opening through which the catheter device is deployed is closed, e.g. by sutures, adhesives and the like to minimize infection at the site. Within a few days or weeks after the tissue has been evaluated for cancer, the temporary catheter device may be removed from the patient. If cancer or pre-cancer cells are found in the specimen removed from the cavity, then a radiation balloon ...

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Номер записи: 26
28-08-2007 дата публикации

Electrosurgical lesion location device

Номер: US0007261712B2
Автор: Fred H. Burbank, Frank R. Louw, Paul Lubock, Richard L. Quick, BURBANK FRED H, LOUW FRANK R, LUBOCK PAUL, QUICK RICHARD L, BURBANK FRED H., LOUW FRANK R., QUICK RICHARD L.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

A device for localizing a target tissue mass in a body includes a tubular trocar portion having a distal end and a proximal end portion that is removably attachable to a handle portion. The trocar portion contains at least a first plurality of locator wires that are movable between a retracted position within the trocar and a deployed position extending radially from the trocar. In a preferred embodiment, the trocar portion has an electrosurgical cutting element at its distal end, and first and second pluralities of locator wires that, when deployed, respectively define first and second locating perimeters.

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Номер записи: 27
10-04-2012 дата публикации

Tissue specimen encapsulation device and method thereof

Номер: US0008152737B2
Автор: Fred H. Burbank, Richard L. Quick, Jacob Frank Louw, Michael L. Jones, Paul Lubock, BURBANK FRED H, QUICK RICHARD L, LOUW JACOB FRANK, JONES MICHAEL L, LUBOCK PAUL, BURBANK FRED H., QUICK RICHARD L., JONES MICHAEL L.
Принадлежит: Senorx, Inc., BURBANK FRED H, QUICK RICHARD L, LOUW JACOB FRANK, JONES MICHAEL L, LUBOCK PAUL, SENORX INC, BURBANK FRED H., QUICK RICHARD L., JONES MICHAEL L., SENORX, INC.

A device for encapsulating tissue specimens includes a wand assembly, a sheath, and a guide assembly. The guide assembly pulls, draws, or otherwise moves the sheath about the tissue specimen. The wand assembly is disposed proximate to the tissue specimen, typically either adjacent or through the specimen. In an aspect of the encapsulating device, the guide assembly has sheath deployment members that are disposed about the tissue specimen. The sheath, which is attached to ends of the sheath deployment members and the wand assembly, is drawn over the tissue specimen as the sheath deployment members are pushed or pulled. The guide assembly is an arm or a housing that rotates about the tissue specimen. The sheath, which is secured at one end to the guide assembly and at another end to the wand assembly, is drawn over the tissue specimen as the guide assembly rotates.

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Номер записи: 28
20-12-2011 дата публикации

Asymmetrical irradiation of a body cavity

Номер: US0008079946B2
Автор: Paul Lubock, Michael L. Jones, Frank R. Louw, LUBOCK PAUL, JONES MICHAEL L, LOUW FRANK R, JONES MICHAEL L., LOUW FRANK R.
Принадлежит: Senorx, Inc., LUBOCK PAUL, JONES MICHAEL L, LOUW FRANK R, SENORX INC, JONES MICHAEL L., LOUW FRANK R., SENORX, INC.

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

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Номер записи: 29
28-05-2009 дата публикации

Biopsy device with fluid delivery to tissue specimens

Номер: US20090137928A1
Автор: Richard L. Quick, Martin V. Shabaz, Frank R. Louw, Paul Lubock, Jason H. Safabash
Принадлежит: SENORX, Inc.

The invention is directed to a system and method for separating and collecting one or more tissue specimens from a target site within a patient and flushing the specimen to remove blood, debris and the like before the specimen is removed from the biopsy device. The flow of flushing fluid to the tissue collector is preferably controlled to coincide with delivery of one or more specimens to the collecting tray or basket of the device or after the receipt of the specimen within the tissue collector to ensure that the fluid is applied to a fresh specimen. The tissue tray or basket within the tissue collector has an open or foraminous portion to facilitate removal of fluid, such as the applied fluid and blood, and other debris from the tissue specimens on the tray. Vacuum is provided within the tissue collector, preferably under the tray to remove fluid and debris from the collector interior.

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Номер записи: 30
29-01-2009 дата публикации

Deployment of polysaccharide markers

Номер: US20090030309A1
Автор: Michael L. Jones, Paul Lubock
Принадлежит: SenoRx, Inc.

The marker member delivery system described has a plurality of marker members disposed within a delivery tube or cannula which contain a suitable polysaccharide such as starch (e.g. corn starch or potato starch) and a binder such as methylcellulose. These marker members are preferably press-formed from powders. The system has preferably has at least one other marker member formed of bioabsorbable material with a radiopaque element attached to or incorporated therein. The marker with a radiopaque marker element is preferably disposed within the delivery tube between two marker members formed of polysaccharide and is preferably formed of a bioabsorbable material other than a polysaccharide.

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Номер записи: 31
20-11-2008 дата публикации

Biopsy anchor device with cutter

Номер: US20080287828A1
Автор: Fred Burbank, Richard L. Quick, Martin V. Shabaz, Paul Lubock, Michael L. Jones
Принадлежит:

A device for accessing and for isolating a desired site within a patient's body, and for obtaining a body of tissue from a patient at the site that includes an electrosurgical cutting electrode near the distal tip of a shaft, an anchoring mechanism and an electrosurgical side-cutting device. Methods are provided for accessing a target site within a patient's body, anchoring a body of tissue at the site, and isolating the body of tissue, at the site. The method may be performed for a surgical biopsy or lumpectomy at the target site within a patient's body.

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Номер записи: 32
18-02-2014 дата публикации

Universal medical device control console

Номер: US0008652121B2
Автор: Richard L. Quick, Martin V. Shabaz, James H. Dabney, Daniel Kussman, Frank R. Louw, Paul Lubock, QUICK RICHARD L, SHABAZ MARTIN V, DABNEY JAMES H, KUSSMAN DANIEL, LOUW FRANK R, LUBOCK PAUL, QUICK RICHARD L., SHABAZ MARTIN V., DABNEY JAMES H., LOUW FRANK R.
Принадлежит: Senorx, Inc., QUICK RICHARD L, SHABAZ MARTIN V, DABNEY JAMES H, KUSSMAN DANIEL, LOUW FRANK R, LUBOCK PAUL, SENORX INC, QUICK RICHARD L., SHABAZ MARTIN V., DABNEY JAMES H., LOUW FRANK R., SENORX, INC.

A control console is disclosed for controlling one or more medical devices. The control console communicates to at least one medical device, and at least one peripheral module associated with the medical device if needed. The control console has a microprocessor for processing data to direct an operation of the medical device.

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Номер записи: 33
11-11-2008 дата публикации

Shapeable electrosurgical scalpel

Номер: US0007449022B2
Автор: Richard L. Quick, Martin Shabaz, Dan Kussman, Paul Lubock, QUICK RICHARD L, SHABAZ MARTIN, KUSSMAN DAN, LUBOCK PAUL, QUICK RICHARD L.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

The invention is directed to an electrosurgical device having a shapeable elongate cutting electrode having a free distal end with an exposed length of at least 0.5 inch and secured by its proximal end to the distal end of a handle. The electrosurgical device is designed for use with a high frequency electrosurgical generator which has an output at a frequency of between about 1 MHz and about 10 MHz, preferably about 3 to about 8 MHz. Preferably, the output has an essentially sinusoidal waveform with little harmonic distortion. The methods provide for the enhanced cutting of a variety of tissue including muscular, connective, glandular and fatty tissue. The device is particularly suitable in performing a breast biopsy.

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Номер записи: 34
14-01-2016 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20160008014A1
Автор: Robert F. Rosenbluth, Brian J. Cox, Paul Lubock
Принадлежит:

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material. 130-. (canceled)31. A method of treating a pulmonary embolism that at least partially restricts blood flow through a pulmonary vessel , the method comprising:delivering an embolectomy device at least partially through the pulmonary embolism, wherein the embolectomy device includes an expandable braided structure;deploying the braided structure within at least a portion of the pulmonary embolism, wherein deploying the braided structure includes withdrawing a delivery sheath such that the braided structure expands and forms a flow channel that restores blood flow through the pulmonary embolism and wherein, in a deployed state, the braided structure has a cylindrical portion positioned between a first portion and a second portion that individually extend radially outwardly from the cylindrical portion such that a surface area to length ratio of the individual first and second portions is greater than the surface area to length ratio of the cylindrical portion;moving the embolectomy device and at least a portion of the pulmonary embolism along the pulmonary vessel; andwithdrawing the embolectomy device and at least a portion of the pulmonary embolism from the pulmonary vessel.32. The method of wherein deploying the braided structure includes expanding at least one of the first and second portions distal to the pulmonary embolism.33. The method of wherein deploying the braided structure comprises expanding the braided structure such that a combined surface area of the cylindrical portion claim 31 , first portion claim 31 , and the second ...

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Номер записи: 35
03-04-2012 дата публикации

Apparatus and method for accessing a body site

Номер: US0008147487B2
Автор: Fred H. Burbank, Paul Lubock, Martin Shabaz, Frank Louw, BURBANK FRED H, LUBOCK PAUL, SHABAZ MARTIN, LOUW FRANK, BURBANK FRED H.
Принадлежит: Senorx, Inc., BURBANK FRED H, LUBOCK PAUL, SHABAZ MARTIN, LOUW FRANK, SENORX INC, BURBANK FRED H., SENORX, INC.

A device and method of using the device to access a desired tissue site within a patient's body and separating a tissue specimen from the tissue site suitable for evaluation. The device includes a probe member having an arcuate tissue-cutting RF powered electrode secured to and distally spaced from the distal end of the probe and a small dimensioned distal extremity which when an inner lumen thereof is subjected to a vacuum, secured tissue for the specimen to the surface of the distal extremity. A circular tissue-cutting blade preferably secured to the distal end of a supporting tube is configured to rotate and move longitudinally along the shaft of the probe member effective to sever a tissue specimen from tissue secured to the surface of the distal extremity of the probe member. The supporting tube covers the separated specimen, and may be disposed within an accessing cannula.

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Номер записи: 36
29-03-2012 дата публикации

REMOTELY IMAGEABLE MARKER SYSTEM AND POLYSACCHARIDE MARKER FOR USE IN SAME

Номер: US20120078092A1
Автор: Michael L. Jones, Paul Lubock, JONES MICHAEL L, LUBOCK PAUL, JONES MICHAEL L.
Принадлежит: SenoRx Inc

A remotely imageable marker system includes a tubular delivery member having an inner lumen and a plurality of marker members. Each marker member of the plurality of marker members comprises a bioabsorbable polysaccharide in sufficient amount to exhibit hemostatic properties and a binder. The plurality of marker members is disposed within the inner lumen of the tubular delivery member.

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Номер записи: 37
19-04-2022 дата публикации

Vascular occlusion devices and methods

Номер: US0011304701B2
Автор: Paul Lubock, Richard Quick, Robert Rosenbluth, Brian J. Cox
Принадлежит: Inceptus Medical, LLC

A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle.

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Номер записи: 38
05-08-2004 дата публикации

Breast biopsy system and methods

Номер: US20040153004A1
Автор: Fred Burbank, Michael Jones, Paul Lubock
Принадлежит: SenoRx, Inc.

An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possibly cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument having a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding ...

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Номер записи: 39
27-03-2008 дата публикации

Tissue specimen encapsulation device and method thereof

Номер: US20080077045A1
Автор: Fred Burbank, Richard Quick, Jacob Louw, Michael Jones, Paul Lubock
Принадлежит: SenoRx, Inc.

A device for encapsulating tissue specimens includes a wand assembly, a sheath, and a guide assembly. The guide assembly pulls, draws, or otherwise moves the sheath about the tissue specimen. The wand assembly is disposed proximate to the tissue specimen, typically either adjacent or through the specimen. In an aspect of the encapsulating device, the guide assembly has sheath deployment members that are disposed about the tissue specimen. The sheath, which is attached to ends of the sheath deployment members and the wand assembly, is drawn over the tissue specimen as the sheath deployment members are pushed or pulled. The guide assembly is an arm or a housing that rotates about the tissue specimen. The sheath, which is secured at one end to the guide assembly and at another end to the wand assembly, is drawn over the tissue specimen as the guide assembly rotates.

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Номер записи: 40
06-07-2006 дата публикации

Graphical user interface for tissue biopsy system

Номер: US20060149162A1
Автор: Derek Daw, Frank Louw, Paul Lubock, Richard Quick, Martin Shabaz
Принадлежит: SenoRx Inc

A graphical user interface is disclosed for a tissue biopsy system having a tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient. The graphical user interface includes a first GUI area representing a first region of the target site from which the tissue cutting member has separated one or more tissue specimens. The graphical user interface further includes a second GUI area, visually distinguishable from the first GUI area, representing a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site.

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Номер записи: 41
19-08-2003 дата публикации

Shapeable electrosurgical scalpel

Номер: US0006607528B1
Автор: Richard L. Quick, Martin Shabaz, Dan Kussman, Paul Lubock, QUICK RICHARD L, SHABAZ MARTIN, KUSSMAN DAN, LUBOCK PAUL, QUICK RICHARD L.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

The invention is directed to an electrosurgical device having a shapeable elongate cutting electrode having a free distal end with an exposed length of at least about 0.25 inch and secured by its proximal end to the distal end of a handle. The electrosurgical device is designed for use with a high frequency electrosurgical generator which has an output at a frequence of between about 1 MHz and about 10 MHz, preferably about 3 to about 8 MHz. Preferably, the output has an essentially sinusoidal waveform with little harmonic distortion. The methods provide for the enhanced cutting of a variety of tissue including muscular, connective, glandular and fatty tissue. The device is particularly suitable in performing a breast biopsy.

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Номер записи: 42
30-05-2013 дата публикации

BIOPSY DEVICE WITH APERTURE ORIENTATION AND IMPROVED TIP

Номер: US20130138014A1
Автор: Martin V. Shabaz, Richard L. Quick, Frank R. Louw, Paul Lubock, Jason H. Safabash
Принадлежит: SENORX, INC.

A biopsy device includes an elongated probe having a central longitudinal axis, a proximal end, a distal end, and an aperture. A tissue penetrating tip includes a proximal base secured to the distal end of the probe. A sharp distal point distal to the proximal base lies on the central longitudinal axis. Each of a first, second and third concave surface is configured to extend from the base to the sharp distal point. The second concave surface is located to intersect the first concave surface to form a first curved cutting edge. A third concave surface is located to intersect the first concave surface to form a second curved cutting edge and is located to intersect the second concave surface to form a third curved cutting edge. Each curved cutting edge extends from the base to the sharp distal point. A tissue cutting device is coaxial with the probe. 168-. (canceled)69. A biopsy device , comprising:a. an elongated probe which has a central longitudinal axis, a proximal end, a distal end, and an aperture proximal to the distal end; i. a proximal base secured to the distal end of the elongated probe,', 'ii. a sharp distal point distal to the proximal base that lies on the central longitudinal axis,', 'iii. a first concave surface configured to extend from the base to the sharp distal point,', 'iv. a second concave surface configured to extend from the base to the sharp distal point and located to intersect the first concave surface to form a first curved cutting edge that extends distally from the base to the sharp distal point, and configured such that the first curved cutting edge has an edge curvature that is concave in a direction toward the central longitudinal axis, and', 'v. a third concave surface circumferentially interposed between the first concave surface and the second concave surface, the third concave surface configured to extend from the base to the sharp distal point and located to intersect the first concave surface to form a second curved cutting ...

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Номер записи: 43
23-12-2014 дата публикации

Biopsy device with fluid delivery to tissue specimens

Номер: US0008915864B2
Автор: Richard L. Quick, Martin V. Shabaz, Frank R. Louw, Paul Lubock, Jason H. Safabash, QUICK RICHARD L, SHABAZ MARTIN V, LOUW FRANK R, LUBOCK PAUL, SAFABASH JASON H, QUICK RICHARD L., SHABAZ MARTIN V., LOUW FRANK R., SAFABASH JASON H.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

The invention is directed to a system and method for separating and collecting one or more tissue specimens from a target site within a patient and flushing the specimen to remove blood, debris and the like before the specimen is removed from the biopsy device. The flow of flushing fluid to the tissue collector is preferably controlled to coincide with delivery of one or more specimens to the collecting tray or basket of the device or after the receipt of the specimen within the tissue collector to ensure that the fluid is applied to a fresh specimen. The tissue tray or basket within the tissue collector has an open or foraminous portion to facilitate removal of fluid, such as the applied fluid and blood, and other debris from the tissue specimens on the tray. Vacuum is provided within the tissue collector, preferably under the tray to remove fluid and debris from the collector interior.

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Номер записи: 44
06-10-2016 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20160287276A1
Автор: Brian J. Cox, Paul Lubock, Robert Rosenbluth, Richard Quick, Philippe Marchand, COX BRIAN J, LUBOCK PAUL, ROSENBLUTH ROBERT, QUICK RICHARD, MARCHAND PHILIPPE, Cox Brian J., Lubock Paul, Rosenbluth Robert, Quick Richard, Marchand Philippe
Принадлежит:

A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member having a plurality of first clot engagement members and second clot engagement members positioned about the circumference of a distal portion of the support member. In an undeployed state, individual first clot engagement members can be linear and have a first length, and individual second clot engagement members can be linear and have a second length that is less than the first length. The clot engagement members can be configured to penetrate clot material along an arcuate path and hold clot material to the clot treatment device. 1. A clot treatment device for treating an embolism within a blood vessel , the clot treatment device comprising:a support member configured to extend through a delivery catheter, wherein the support member has a proximal portion and a distal portion;a plurality of first clot engagement members positioned about the circumference of the distal portion of the support member, wherein, in the deployed state, individual first clot engagement members extend radially outwardly with respect to the support member and have a curved portion that includes a first radially furthest apex that extends a first radial distance from the support member;a plurality of second clot engagement members positioned about the circumference of the distal portion of the support member, wherein, in the deployed state, individual second clot engagement members have a curved portion that includes a second radially furthest apex that extends a second radial distance from the support member, and wherein the first radial distance is greater than the second radial distance;wherein, in the deployed state, individual curved portions of the first and second clot engagement members project radially outwardly relative to the support ...

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Номер записи: 45
16-05-2013 дата публикации

MRI DETECTABLE OBTURATOR

Номер: US20130123829A1
Автор: Paul Lubock, Michael L. Jones, Ethan Broadaway, Frank R. Louw
Принадлежит: SENORX, INC.

An obturator for marking an intracorporeal site includes an elongated shaft having an inner lumen, a proximal end, and a substantially closed distal end, the substantially closed distal end being formed of a penetrable membrane. A stylet has an MRI detectable distal shaft portion configured for removable insertion into the inner lumen of the elongated shaft to a location proximal to the penetrable membrane. The MRI detectable distal shaft portion is configured to not interfere with magnetic resonance imaging of tissue proximate thereto. 1. An obturator for marking an intracorporeal site comprising:an elongated shaft having an inner lumen, a proximal end, and a substantially closed distal end, the substantially closed distal end being formed of a penetrable membrane; anda stylet having an MRI detectable distal shaft portion configured for removable insertion into the inner lumen of the elongated shaft to a location proximal to the penetrable membrane, the MRI detectable distal shaft portion configured to not interfere with magnetic resonance imaging of tissue proximate thereto.233-. (canceled)34. The obturator of claim 1 , wherein the substantially closed distal end has a rounded external surface.35. A marker delivery apparatus claim 1 , comprising:an MRI detectable obturator having an elongated shaft, an inner lumen, a proximal end, and a substantially closed distal end, the substantially closed distal end being formed of a penetrable membrane, the MRI detectable obturator configured to not interfere with magnetic resonance imaging of tissue proximate thereto; anda marker delivery tube configured to be slidably disposed within the inner lumen of the MRI detectable obturator, the marker delivery tube having a marker delivery lumen, a proximal end, and a distal tip, the marker delivery lumen being configured to contain one or more tissue markers, and the distal tip being configured to puncture the penetrable membrane of the substantially closed distal end of the MRI ...

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Номер записи: 46
05-05-2016 дата публикации

CAVITY-FILLING BIOPSY SITE MARKERS

Номер: US20160120510A1
Автор: Fred H. Burbank, Paul Lubock, Michael L. Jones
Принадлежит: SenoRx, Inc.

A mass includes particles that exhibit an in vivo lifetime and that include a bioresorbable material and bubble cavities disposed in the particles, wherein the bubble cavities have length, width, and height dimensions at least one of which is less than or equal to about 2000 microns. The mass exhibits enhanced detectability by ultrasound energy during the lifetime; the lifetime begins upon exposure to in vivo fluids and ends between about 2 and about 20 weeks afterward; and a zero or non-zero fluid-to-solid ratio. 175-. (canceled)77. The mass of wherein the lifetime ends between about 6 and about 12 weeks afterward.78. The mass of wherein all of the length claim 77 , width claim 77 , and height dimensions are less than or equal to about 2000 microns.79. The mass of wherein all of the length claim 78 , width claim 78 , and height dimensions are between about 10 and about 500 microns.80. The mass of wherein all of the length claim 79 , width claim 79 , and height dimensions are between about 20 and about 200 microns.81. The mass of having a volume between about 0.2 and about 1.2 ml.82. The mass of having a volume of about 0.5 ml.83. The mass of wherein the bioresorbable material comprises a bioresorbable polymeric material.84. The mass of wherein the bioresorbable polymeric material comprises polymers claim 83 , copolymers claim 83 , polymer alloys claim 83 , polymer mixtures claim 83 , or other combinations of poly(esters) claim 83 , poly(hydroxy acids) claim 83 , poly(lactones) claim 83 , poly(amides) claim 83 , poly(ester-amides) claim 83 , poly(amino acids) claim 83 , poly(anhydrides) claim 83 , poly(orthoesters) claim 83 , poly(carbonates) claim 83 , poly(phosphazines) claim 83 , poly(thioesters) claim 83 , poly(urethanes) claim 83 , poly(ester urethanes) claim 83 , polysaccharides claim 83 , polylactic acids claim 83 , polyglycolic acids claim 83 , polycaproic acids claim 83 , polybutyric acids claim 83 , or polyvaleric acids.85. The mass of wherein the ...

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Номер записи: 47
13-07-2023 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20230218313A1
Автор: Robert F. Rosenbluth, Brian J. Cox, Paul Lubock, Richard Quick
Принадлежит:

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material.

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Номер записи: 48
07-03-2024 дата публикации

SINGLE INSERTION DELIVERY SYSTEM FOR TREATING EMBOLISM AND ASSOCIATED SYSTEMS AND METHODS

Номер: US20240074771A1
Автор: Richard Quick, Benjamin Edward Merritt, John Coleman Thress, Paul Lubock, Thomas M. Tu
Принадлежит:

Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, engaging an interventional device of a catheter system with clot material in a blood vessel and withdrawing the interventional device and the portion of the clot material through a guide catheter. In some embodiments, the catheter system can include an attachment/valve member coupled to a proximal portion of the guide catheter, and the method can include unsealing the attachment/valve member to facilitate withdrawing the interventional device through the attachment/valve member without significant retention of clot material within the attachment/valve member. The method can further include resealing and aspirating the guide catheter before advancing another interventional device to the clot material to again engage and remove clot material from the blood vessel.

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Номер записи: 49
27-06-2024 дата публикации

HEMOSTASIS VALVES AND METHODS OF USE

Номер: US20240207593A1
Автор: Benjamin E. Merritt, John C. Thress, Paul Lubock
Принадлежит:

Devices, systems, and methods for sealing medical devices, particularly during intravascular access, are disclosed herein. Some aspects relate to a hemostatic valve for sealing a wide range of medical devices, such as catheters, wires, embolectomy systems. The valve can include an elongate member having a first end, a second end, and a central lumen extending therebetween. A reinforcement structure extends along at least a portion of the elongate member and is coupled to the elongate member. A shell defining a first aperture and a second aperture may be included, which first and second apertures can be fluidly coupled by the elongate member. A tensioning mechanism is coupled to the shell and to the elongate member, the tensioning mechanism can be moveable between a first configuration wherein the tensioning mechanism is collapsed and the central lumen is sealed and a second configuration wherein the central lumen is open.

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Номер записи: 50
21-04-2011 дата публикации

MARKER OR FILLER FORMING FLUID

Номер: US20110092815A1
Автор: Fred H. Burbank, Michael L. Jones, Frank Louw, Paul Lubock
Принадлежит: SENORX, Inc.

A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A releasable remotely detectable distal tip is coupled to the distal end of the delivery tube and is configured to be released to remain within the porous bioabsorbable body within the cavity upon the formation thereof.

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Номер записи: 51
14-02-2019 дата публикации

DEVICES AND METHODS FOR TREATING VASCULAR OCCLUSION

Номер: US20190046219A1
Автор: Phil Marchand, Benjamin E. Merritt, John C. Thress, Jacob F. Louw, Paul Lubock, Brian J. Cox, MARCHAND PHIL, MERRITT BENJAMIN E, THRESS JOHN C, LOUW JACOB F, LUBOCK PAUL, COX BRIAN J, Marchand, Phil, Merritt, Benjamin E., Thress, John C., Louw, Jacob F., Lubock, Paul, Cox, Brian J.
Принадлежит:

Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a fenestrated structure, a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter; retracting the self-expanding member to unstack the portion of the net-like filament mesh structure and to capture the portion of the thrombus; and withdrawing the thrombus extraction device from the body. 1. A thrombus extraction device for removal of a vascular thrombus from a blood vessel of a patient , the thrombus extraction device comprising:a coring element shaft;a stop shaft slidably positioned within the coring element shaft;an expandable coring element having a proximal end portion and a distal end portion, wherein the proximal end portion of the coring element is coupled to the coring element shaft, and wherein the coring element is configured to core and separate a portion of the vascular thrombus from the blood vessel;an expandable cylindrical structure having a proximal end portion and a distal end portion, wherein the proximal end portion of the cylindrical structure is coupled to the distal end portion of the coring element, and wherein the cylindrical structure is configured to capture the portion of the vascular thrombus separated from the blood vessel; andan expansion mechanism coupled to the stop shaft and the coring element, wherein proximal retraction of the stop shaft relative to the coring element shaft ...

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Номер записи: 52
09-08-2016 дата публикации

Biopsy device with aperture orientation and improved tip

Номер: US0009408592B2
Автор: Martin V. Shabaz, Richard L. Quick, Frank R. Louw, Paul Lubock, Jason H. Safabash, SHABAZ MARTIN V, QUICK RICHARD L, LOUW FRANK R, LUBOCK PAUL, SAFABASH JASON H, Shabaz Martin V., Quick Richard L., Louw Frank R., Lubock Paul, Safabash Jason H.
Принадлежит: SENORX, INC., SHABAZ MARTIN V, QUICK RICHARD L, LOUW FRANK R, LUBOCK PAUL, SAFABASH JASON H, SENORX INC, Shabaz Martin V., Quick Richard L., Louw Frank R., Lubock Paul, Safabash Jason H.

The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component which is releasably secured to the driver component. The probe component has an elongated tubular section, a penetrating distal tip and a tissue receiving aperture in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The driver has drive members for operating the elements of the probe component. The tissue penetrating distal tip preferably has a triple concave curvature shape with three curved cutting edges leading to a sharp distal point.

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Номер записи: 53
24-04-2014 дата публикации

MARKER OR FILLER FORMING FLUID

Номер: US20140114186A1
Автор: Fred H. Burbank, Michael L. Jones, Frank Louw, Paul Lubock, BURBANK FRED H, JONES MICHAEL L, LOUW FRANK, LUBOCK PAUL, BURBANK FRED H., JONES MICHAEL L.
Принадлежит: SenoRx, Inc.

A system for at least partially filling and marking a cavity within a patient includes a delivery device. A quantity of marker forming fluid is located within the delivery device. The quantity of marker forming fluid is configured to at least partially fill the cavity and form therein a bioabsorbable body after delivery into the cavity from the delivery device. A radiopaque marker, separate from the quantity of marker forming fluid and releasably attached to a portion of the delivery device, is configured to be delivered into the quantity of marker forming fluid in the cavity from the delivery device and configured to remain in the bioabsorbable body upon the formation of the bioabsorbable body in the cavity. 1. A system for at least partially filling and marking a cavity within a patient , comprising:a delivery device;a quantity of marker forming fluid located within the delivery device, the quantity of marker forming fluid configured to at least partially fill the cavity and form therein a bioabsorbable body after delivery into the cavity from the delivery device; andradiopaque marker separate from the quantity of marker forming fluid and releasably attached to a portion of the delivery device, the radiopaque marker configured to be delivered into the quantity of marker forming fluid in the cavity from the delivery device and configured to remain in the bioabsorbable body upon the formation of the bioabsorbable body in the cavity.218-. (canceled)19. The system of claim 1 , wherein the delivery device includes a delivery tube claim 1 , and the radiopaque marker is threadably connected to a distal end of the delivery tube.20. The system of claim 19 , wherein the radiopaque marker is a distal tip of the delivery tube.21. The system of claim 1 , wherein the radiopaque marker is releasably attached to an external surface of the delivery device.22. The system of claim 1 , wherein the marker forming fluid comprises a non-aqueous solvent which is relatively soluble in a ...

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Номер записи: 54
01-11-2007 дата публикации

High frequency power source

Номер: US20070255271A1
Автор: James Dabney, Richard Quick, Conrad Sawicz, Paul Lubock, Dan Kussman
Принадлежит: SenoRx, Inc.

A high frequency electrosurgical power generator configured to produce electrical power at a frequency of about 1 to about 14 MHz and preferably having an essentially sinusoidal waveform with a voltage level up to 1,000 Vrms, and a current level up to 5 Amps. The output of the high frequency electrosurgical power generator is connected to an electrosurgical tool configured to receive the voltage and current produced by the electrosurgical power generator and deliver the voltage and current to an electrosurgical site. The output of the electrosurgical generator preferably is an essentially sinusoid waveform with a frequency between about 3 MHz and about 8 MHz, up to about 700 volts rms, up to about 2 amps, with a total power of up to 1,000 watts.

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Номер записи: 55
06-12-2016 дата публикации

Tissue specimen isolating and damaging device and method

Номер: US0009510809B2
Автор: Fred H. Burbank, Paul Lubock, BURBANK FRED H, LUBOCK PAUL, Burbank Fred H., Lubock Paul
Принадлежит: SenoRx, Inc., SENORX INC

A device and method for treatment of a tissue specimen disposed in surrounding tissue includes isolating the tissue specimen from the surrounding tissue by using a separating device to sever and separate the tissue specimen from the surrounding tissue; damaging the isolated tissue specimen with a tissue specimen damaging device; and using an encapsulating device to encapsulate the isolated and damaged tissue specimen, the encapsulating device configured for operation independent from the separating device and the tissue specimen damaging device.

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Номер записи: 56
18-08-2011 дата публикации

METHOD FOR MAINTAINING ACCESS TO A BIOPSY SITE

Номер: US20110201966A1
Автор: Paul Lubock, Michael L. Jones, LUBOCK PAUL, JONES MICHAEL L, JONES MICHAEL L.
Принадлежит: SenoRx, Inc.

A method for maintaining access to a biopsy site within a patient, includes forming a passageway from an opening in an exterior site on the patient to a desired location for a biopsy specimen within the patient; removing a tissue specimen from the desired location thereby leaving a biopsy cavity; providing a temporary catheter having an elongate shaft, a flexible proximal shaft section, and a distal shaft section having a cavity filling member thereon; inserting the cavity filling member on the distal shaft section into the biopsy cavity; inflating the cavity filling member after inserting the cavity filling member within the biopsy cavity, but before closing the opening, using the flexible proximal shaft section; placing the flexible proximal shaft section at an intracorporeal location; and closing the opening so as to seal the passageway.

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Номер записи: 57
28-07-2011 дата публикации

MARKER DELIVERY DEVICE WITH OBTURATOR

Номер: US20110184449A1
Автор: Paul Lubock, Richard Quick, LUBOCK PAUL, QUICK RICHARD
Принадлежит: SenoRx, Inc.

A marker delivery device includes an obturator having an elongated shaft, an internal lumen, a proximal end, and a substantially sealed distal end. The substantially sealed distal end is formed of a penetrable membrane. A marker delivery tube is configured to be slidably disposed within the internal lumen of the obturator. The marker delivery tube has a marker delivery lumen, a proximal end, and a distal tip. The marker delivery lumen is configured to contain one or more tissue markers. The distal tip is configured to puncture the penetrable membrane of the substantially sealed distal end of the obturator to form a passage through which the distal tip extends to facilitate delivery of the one or more tissue markers.

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Номер записи: 58
03-08-2023 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20230240706A1
Автор: Robert F. Rosenbluth, Brian J. Cox, Paul Lubock, Richard Quick
Принадлежит:

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material.

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Номер записи: 59
14-01-2020 дата публикации

Interlocking loop coupling/decoupling system for deploying vascular implant devices

Номер: US0010531877B2
Автор: Martin Shabaz, Claudio Plaza, Richard Quick, Paul Lubock, Brian J. Cox, SHABAZ MARTIN, PLAZA CLAUDIO, QUICK RICHARD, LUBOCK PAUL, COX BRIAN J, Shabaz, Martin, Plaza, Claudio, Quick, Richard, Lubock, Paul, Cox, Brian J.
Принадлежит: INCEPTUS MEDICAL LLC, Inceptus Medical LLC

In a system and method for deployment of an implant device, the implant device includes a first loop at its proximal end, and a deployment tool has a second loop attached at its distal end. A release wire slidably disposed within the deployment tool has a distal end extending through the first and second loops to releasably couple the implant device to the deployment tool, and a proximal portion extending from a proximal end of the deployment tool, which is held in a retraction device. The retraction device is operable to hold the proximal end of the deployment tool and to pull the release wire proximally through the deployment tool until the distal end of the release wire is withdrawn from the first and second loops to decouple the implant device from the deployment tool.

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Номер записи: 60
09-12-2003 дата публикации

Tissue specimen isolating and damaging device and method

Номер: US0006659105B2
Автор: Fred H. Burbank, Paul Lubock, BURBANK FRED H, LUBOCK PAUL, BURBANK FRED H.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

A device and method for treatment of a tissue specimen disposed in surrounding tissue has a tissue specimen isolating tool and a tissue specimen damager. The tissue specimen isolating tool isolates the tissue specimen from the surrounding tissue. The tissue specimen damager damages the tissue, with a possible end result being necrosis. The severing tool may have a cutting member that is extendable to an outwardly radially bowed position about device. The tissue specimen is isolated by rotating the cutting member about the tissue specimen. The cutting member may be functionally connected to a cutting member radio frequency generation source. The tissue specimen damager may damage the tissue specimen using ionizing radiation, cutting devices, thermal treatment devices, chemical treatment devices, or sealing an outer boundary of the tissue specimen.

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Номер записи: 61
21-05-2013 дата публикации

Marker or filler forming fluid

Номер: US0008447386B2
Автор: Fred H. Burbank, Michael L. Jones, Frank Louw, Paul Lubock, BURBANK FRED H, JONES MICHAEL L, LOUW FRANK, LUBOCK PAUL, BURBANK FRED H., JONES MICHAEL L.
Принадлежит: Senorx, Inc., BURBANK FRED H, JONES MICHAEL L, LOUW FRANK, LUBOCK PAUL, SENORX INC, BURBANK FRED H., JONES MICHAEL L., SENORX, INC.

A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A releasable remotely detectable distal tip is coupled to the distal end of the delivery tube and is configured to be released to remain within the porous bioabsorbable body within the cavity upon the formation thereof.

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Номер записи: 62
07-11-2023 дата публикации

Devices and methods for treating vascular occlusion

Номер: US0011806033B2
Автор: Phil Marchand, Benjamin E. Merritt, John C. Thress, Jacob F. Louw, Paul Lubock, Brian J. Cox
Принадлежит: Inari Medical, Inc.

Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a fenestrated structure, a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter; retracting the self-expanding member to unstack the portion of the net-like filament mesh structure and to capture the portion of the thrombus; and withdrawing the thrombus extraction device from the body.

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Номер записи: 63
17-09-2019 дата публикации

Brachytherapy device for facilitating asymmetrical irradiation of a body cavity

Номер: US0010413750B2
Автор: Paul Lubock, Michael L. Jones, Frank R. Louw, LUBOCK PAUL, JONES MICHAEL L, LOUW FRANK R, Lubock, Paul, Jones, Michael L., Louw, Frank R.
Принадлежит: HOLOGIC, INC., HOLOGIC INC, Hologic, Inc.

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

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Номер записи: 64
25-08-2005 дата публикации

Breast biopsy system and methods

Номер: US20050187490A1
Автор: Fred Burbank, Michael Jones, Paul Lubock
Принадлежит: Xerox Corporation

An apparatus and method are provided for precisely isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required, while minimizing the risk of migration of possibly cancerous cells from the lesion to surrounding tissue or the bloodstream. In particular, the apparatus comprises a biopsy instrument having a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along the shaft. The cutting element is actuatable between a radially retracted position and a radially extended position. Advantageously, the instrument is rotatable about its axis in the radially extended position to isolate a desired tissue specimen from surrounding ...

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Номер записи: 65
13-03-2008 дата публикации

Vacuum device and method for treating tissue adjacent a body cavity

Номер: US20080064915A1
Автор: Paul Lubock
Принадлежит: SenoRx, Inc.

Devices and methods are provided for applying vacuum near to devices for delivering treatments to tissue adjacent a body cavity, effective to draw adjacent tissue near to such devices and to enhance treatment of the tissue. Body cavities include natural body cavities and cavities remaining after removal of tissue such as cancerous tissue. A device may include an inner balloon assembly with an inflation conduit. A sheath assembly having a fluid-permeable sheath wall may enclose the inner balloon assembly. Vacuum applied to the space between the sheath and the inner balloon is useful to draw tissue into contact with the device, improving treatment effectiveness. Methods for treating tissue with such devices and systems are also provided. Treatments may include providing radioactive material for radiation treatment, providing chemotherapeutic material for chemotherapy, providing thermal treatment, and combinations thereof. Systems may include devices of the invention and a vacuum source.

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Номер записи: 66
20-05-2003 дата публикации

Methods and chemical preparations for time-limited marking of biopsy sites

Номер: US0006567689B2
Автор: Fred H. Burbank, Paul Lubock, Michael L. Jones, Nancy Forcier, BURBANK FRED H, LUBOCK PAUL, JONES MICHAEL L, FORCIER NANCY, BURBANK FRED H., JONES MICHAEL L.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

Detectable markers that may be introduced into a cavity created by removal of a biopsy specimen to mark the location of the biopsy site so that it may be located in a subsequent medical/surgical procedure. The markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.

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Номер записи: 67
03-10-2019 дата публикации

BIOPSY DEVICE WITH SELECTABLE TISSUE RECEIVING APERATURE ORIENTATION AND SITE ILLUMINATION

Номер: US20190298319A1
Автор: Martin V. Shabaz, Richard L. Quick, Frank R. Louw, Paul Lubock, Jason H. Safabash, SHABAZ MARTIN V, QUICK RICHARD L, LOUW FRANK R, LUBOCK PAUL, SAFABASH JASON H, Shabaz, Martin V., Quick, Richard L., Louw, Frank R., Lubock, Paul, Safabash, Jason H.
Принадлежит:

A biopsy device includes a disposable elongated probe component having a coaxial arrangement of an elongated tubular section and an elongated tissue cutting member, and having a coaxial arrangement of a first driven gear, a second driven gear, and a third driven gear. The first driven gear is configured to rotate the elongated tubular section. The second driven gear is configured to rotate to longitudinally move the elongated tissue cutting member. The third driven gear is configured to rotate or oscillate the elongated tissue cutting member. A driver component has a coaxial arrangement of a first drive gear, a second drive gear, and a third drive gear. The first drive gear is drivably engaged with the first driven gear. The second drive gear is drivably engaged with the second driven gear. The third drive gear is drivably engaged with the third driven gear. 156-. (canceled)57. A biopsy device , comprising:a disposable elongated probe component having a first coaxial arrangement of an elongated tubular section and an elongated tissue cutting member, and having a coaxial arrangement of a first driven gear, a second driven gear, and a third driven gear, the first driven gear being coupled to the elongated tubular section and configured to rotate the elongated tubular section, the second driven gear being coupled to the elongated tissue cutting member and configured to longitudinally move the elongated tissue cutting member, and the third driven gear being coupled to the elongated tissue cutting member and configured to rotate or oscillate the elongated tissue cutting member; anda driver component having a second coaxial arrangement of a first drive gear, a second drive gear, and a third drive gear, the first drive gear drivably engaged with the first driven gear, the second drive gear drivably engaged with the second driven gear, and the third drive gear drivably engaged with the third driven gear.58. The biopsy device of claim 57 , wherein the first driven gear is ...

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Номер записи: 68
09-10-2014 дата публикации

EMBOLIC PROTECTION DEVICE AND METHODS OF USE

Номер: US20140303667A1
Автор: Brian J. Cox, Paul Lubock, Robert Rosenbluth, Richard Quick, COX BRIAN J, LUBOCK PAUL, ROSENBLUTH ROBERT, QUICK RICHARD, COX BRIAN J.
Принадлежит: INCEPTUS MEDICAL, LLC

Embolic protection devices for placement in an arterial system of a human and methods of using such devices. In one embodiment, the device includes a filter having a first filter section configured to be deployed along the ascending aorta and aortic arch, a tapered second filter section extending proximally from the first filter section, and a proximal portion extending proximally from the second filter section. The second filter section is configured to be deployed along the descending aorta, and the proximal portion extends to a position below a renal artery. The embolic protection device can be configured to continuously filter the arterial system blood between a distal end of the first filter section to a position within the arterial system downstream of the renal artery. 1. An embolic protection device for placement in an arterial system of a human , the arterial system having an ascending aorta , an aortic arch , and a descending aorta , wherein a brachiocephalic artery ostium and at least one of a left common carotid artery ostium and a left subclavian artery ostium branch from the aortic arch , comprising: a first filter section having a first cross-sectional dimension in the deployed configuration sufficient to anchor the embolic protection device within the ascending aorta and to provide passage of a therapeutic device through the first filter section; and', 'a tapered second filter section extending proximally from the first filter section; and, 'a filter having a delivery configuration and a deployed configuration, the filter having—'}a proximal portion extending proximally from the second filter section to an extracorporeal location.2. The embolic protection device of wherein the first filter section in the deployed configuration is configured to contact the aortic arch at the brachiocephalic artery ostium and at least one of the left common carotid artery ostium or the left subclavian artery ostium.3. The embolic protection device of wherein the filter ...

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Номер записи: 69
11-07-2023 дата публикации

Hemostasis valves and methods of use

Номер: US0011697012B2
Автор: Benjamin E. Merritt, John C. Thress, Paul Lubock
Принадлежит: Inari Medical, Inc.

Devices, systems, and methods for sealing medical devices, particularly during intravascular access, are disclosed herein. Some aspects relate to a hemostatic valve for sealing a wide range of medical devices, such as catheters, wires, embolectomy systems. The valve can include an elongate member having a first end, a second end, and a central lumen extending therebetween. A reinforcement structure extends along at least a portion of the elongate member and is coupled to the elongate member. A shell defining a first aperture and a second aperture may be included, which first and second apertures can be fluidly coupled by the elongate member. A tensioning mechanism is coupled to the shell and to the elongate member, the tensioning mechanism can be moveable between a first configuration wherein the tensioning mechanism is collapsed and the central lumen is sealed and a second configuration wherein the central lumen is open.

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Номер записи: 70
14-05-2024 дата публикации

System for treating embolism and associated devices and methods

Номер: US0011980537B2
Автор: Ben Merritt, Jacqueline Macias, Brian Michael Strauss, Thomas Tu, John Coleman Thress, Paul Lubock
Принадлежит: Inari Medical, Inc.

Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.

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Номер записи: 71
05-08-2021 дата публикации

DEVICES AND METHODS FOR TREATING VASCULAR OCCLUSION

Номер: US20210236148A1
Автор: Phil Marchand, Benjamin E. Merritt, John C. Thress, Jacob F. Louw, Paul Lubock, Brian J. Cox
Принадлежит:

Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a fenestrated structure, a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter; retracting the self-expanding member to unstack the portion of the net-like filament mesh structure and to capture the portion of the thrombus; and withdrawing the thrombus extraction device from the body. 1. A method for removal of a vascular thrombus from a blood vessel of a patient , the method comprising:positioning a thrombus extraction device at least partially distal to the thrombus in the blood vessel, wherein the thrombus extraction device includes an expandable coring element and an expandable cylindrical structure, and wherein a proximal portion of the cylindrical structure is coupled to a distal portion of the coring element;expanding the coring element by proximally retracting a first shaft of the thrombus extraction device relative to a second shaft of the thrombus extraction device, wherein a proximal portion of the coring element is coupled to the second shaft, and wherein the first shaft is slidably positioned within the second shaft; andretracting the thrombus extraction device at least partially through the thrombus such that (a) the coring element separates a portion of the thrombus from a wall of the blood vessel and (b) the cylindrical structure captures the portion of the thrombus.2. The method of wherein the ...

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Номер записи: 72
31-12-2015 дата публикации

METHODS AND APPARATUS FOR TREATING SMALL VESSEL THROMBOEMBOLISMS

Номер: US20150374391A1
Автор: Richard Quick, Brian J. Cox, Paul Lubock, Robert F. Rosenbluth
Принадлежит:

A device and method for intravascular treatment of an embolism, and particularly an embolism within a small vessel, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member configured to extend through a delivery catheter and a plurality of clot engagement members positioned about the circumference of a distal portion of the support member. The individual clot engagement members can have a first portion and a second portion extending from the first portion, and the first portions can have a proximal region attached to the support member. In the deployed state, the individual second portions can extend from the distal region of one of the first portions and project radially outwardly relative to the support member in a curve that has a proximally extending section which defines a proximally facing concave portion. 120-. (canceled)21. A method of treating a cerebral or coronary embolism within a small vessel that at least partially restricts blood flow through the small vessel , the method comprising:delivering an embolectomy device to a treatment site within the small vessel without the use of a guidewire; The embolectomy device includes a first plurality of clot engagement members configured to deploy at a first location along the device and a second plurality of clot engagement members configured to deploy at a second location along the device proximal of the first location, and', a terminus of at least one of a the clot engagement members of the first and/or second pluralities of clot engagement members penetrates through the clot material along an arcuate path that extends radially outward, then proximally with respect to the elongated shaft, and then curves radially inwardly, whereby the clot material is held by at least one of the clot engagement members of the first and/or second pluralities of clot engagement members;', 'at least one of the first plurality of clot ...

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Номер записи: 73
18-02-2021 дата публикации

GRAPHICAL USER INTERFACE FOR TISSUE BIOPSY SYSTEM

Номер: US20210045653A1
Автор: Derek J. Daw, Frank R. Louw, Paul Lubock, Richard L. Quick, Martin V. Shabaz, DAW DEREK J, LOUW FRANK R, LUBOCK PAUL, QUICK RICHARD L, SHABAZ MARTIN V, Daw, Derek J., Louw, Frank R., Lubock, Paul, Quick, Richard L., Shabaz, Martin V.
Принадлежит:

A screen providing a GUI is disclosed for a tissue biopsy system having a tissue cutting member. The screen includes a first GUI area configured to represent a first region of the target site from which at least one tissue specimen has been separated from tissue at the target site by the tissue cutting member. The screen further includes a second GUI area configured to represent a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site. The screen includes a third GUI area configured to represent a third region in which the tissue cutting member is deployed to separate a tissue specimen from tissue at the target site. The GUI is configured to update the first GUI area, the second GUI area, and the third GUI area as the tissue cutting member is rotated within the patient. 141-. (canceled)42. A screen providing a graphical user interface (GUI) for a tissue biopsy system having a tissue cutting member with a tissue receiving aperture , the tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient , the screen having the graphical user interface comprising:a. a first GUI area configured to represent a first region of the target site from which at least one tissue specimen has been separated from tissue at the target site by the tissue cutting member;b. a second GUI area, visually distinguishable from the first GUI area, configured to represent a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site; andc. a third GUI area, visually distinguishable from the first and second GUI areas, configured to represent a third region in which the tissue cutting member is deployed to separate a tissue specimen from tissue at the target site,wherein the graphical user interface is configured to generate each of the first GUI area, the second GUI area, and the third GUI ...

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Номер записи: 74
05-06-2014 дата публикации

Methods And Apparatus For Treating Embolism

Номер: US20140155908A1
Автор: Robert F. Rosenbluth, Brian J. Cox, Paul Lubock, ROSENBLUTH ROBERT F, COX BRIAN J, LUBOCK PAUL, ROSENBLUTH ROBERT F., COX BRIAN J.
Принадлежит:

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material. 1. A method of treating a pulmonary embolism comprising:delivering an embolectomy device through the heart to a pulmonary embolism that at least partially restricts blood flow through a pulmonary vessel, wherein the embolectomy device comprises an expandable cylindrical section and a radial expansion member configured to expand outwardly from the cylindrical section;deploying the embolectomy device within the pulmonary embolism so as to restore blood flow through said pulmonary embolism,wherein deploying the embolectomy device comprises expanding the cylindrical section within the pulmonary embolism such that the cylindrical section forms an expanded flow channel through the pulmonary embolism and expanding the radial expansion member to a greater extent than the cylindrical section, and wherein at full exapansion of the cylindrical member the radial expansion member projects outward from the cylindrical member;moving the embolectomy device and at least a portion of the pulmonary embolism along the pulmonary vessel; andwithdrawing the embolectomy device and at least a portion of said the pulmonary embolism from the pulmonary vessel.2. A method according to claim 1 , wherein deploying the embolectomy device comprises expanding a plurality of radial extensions of said embolectomy device.3. A method according to claim 2 , wherein at least one of said plurality of radial extensions is expanded distal to said pulmonary embolism.4. A method according to claim 1 , wherein said deploying the embolectomy device comprises expanding a plurality of ...

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Номер записи: 75
31-10-2017 дата публикации

Fibrous marker and intracorporeal delivery thereof

Номер: US0009801688B2
Автор: Michael L. Jones, Paul Lubock, Lloyd H. Malchow, JONES MICHAEL L, LUBOCK PAUL, MALCHOW LLOYD H, Jones Michael L., Lubock Paul, Malchow Lloyd H.
Принадлежит: SenoRx, Inc., SENORX INC

An intracorporeal marker delivery system includes a delivery device including a delivery cannula and a plunger. The delivery cannula has an inner lumen, a distal tip, and a discharge opening in communication with the inner lumen. A radiographically detectable marker having a fibrous-body and a radiographically detectable marker element coupled to the fibrous body is disposed within and pushable by the plunger through the inner lumen of the delivery cannula. An MRI detectable distal tip plug is disposed at least in part within a distal portion of the inner lumen distal to the radiographically detectable marker, and configured to partially occlude the discharge opening in the delivery cannula. An ultrasound detectable short term marker is interposed between the radiographically detectable marker and the MRI detectable distal tip plug in the inner lumen of the delivery cannula.

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Номер записи: 76
17-05-2011 дата публикации

Marker delivery system with obturator

Номер: US0007945307B2
Автор: Paul Lubock, Richard Quick, LUBOCK PAUL, QUICK RICHARD
Принадлежит: Senorx, Inc., SENORX INC, SENORX, INC.

A marker delivery device is described which has an obturator with an elongated shaft, an inner lumen, a proximal end, and a substantially sealed distal end. One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker(s) is disposed within an inner lumen of a marker delivery tube which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.

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Номер записи: 77
03-05-2011 дата публикации

Vacuum device and method for treating tissue adjacent a body cavity

Номер: US0007935044B2
Автор: Paul Lubock, LUBOCK PAUL
Принадлежит: Senorx, Inc., SENORX INC, SENORX, INC.

Devices and methods are provided for applying vacuum near to devices for delivering treatments to tissue adjacent a body cavity, effective to draw adjacent tissue near to such devices and to enhance treatment of the tissue. Body cavities include natural body cavities and cavities remaining after removal of tissue such as cancerous tissue. A device may include an inner balloon assembly with an inflation conduit. A sheath assembly having a fluid-permeable sheath wall may enclose the inner balloon assembly. Vacuum applied to the space between the sheath and the inner balloon is useful to draw tissue into contact with the device, improving treatment effectiveness. Methods for treating tissue with such devices and systems are also provided. Treatments may include providing radioactive material for radiation treatment, providing chemotherapeutic material for chemotherapy, providing thermal treatment, and combinations thereof. Systems may include devices of the invention and a vacuum source.

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Номер записи: 78
14-09-2006 дата публикации

Temporary catheter for biopsy site tissue fixation

Номер: US20060205992A1
Автор: Paul Lubock, Michael Jones
Принадлежит: SenoRx, Inc.

Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. One embodiment of the catheter device includes an elongated shaft having a proximal shaft section which is flexible enough to be folded or coiled into a configuration for deployment within the patient. An alternate embodiment includes a catheter device having one or more detachable proximal shaft sections and having at least one one-way valve to restrict fluid flow of inflation fluid to flow to the balloon. After deployment of the catheter device completely within the patient, the opening through which the catheter device is deployed is closed, e.g. by sutures, adhesives and the like to minimize infection at the site. Within a few days or weeks after the tissue has been evaluated for cancer, the temporary catheter device may be removed from the patient. If cancer or pre-cancer cells are found in the specimen removed from the cavity, then a radiation balloon ...

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Номер записи: 79
04-07-2002 дата публикации

Methods and apparatus for securing medical instruments to desired locations in a patient's body

Номер: US20020087095A1
Автор: Fred Burbank, Paul Lubock, Michael Jones, Richard Quick
Принадлежит: SenoRx, Inc.

Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

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Номер записи: 80
16-05-2002 дата публикации

Tissue specimen encapsulation device and method thereof

Номер: US20020058885A1
Автор: Fred Burbank, Richard Quick, Jacob Louw, Michael Jones, Paul Lubock
Принадлежит:

A device for encapsulating tissue specimens includes a wand assembly, a sheath, and a guide assembly. The guide assembly pulls, draws, or otherwise moves the sheath about the tissue specimen. The wand assembly is disposed proximate to the tissue specimen, typically either adjacent or through the specimen. In an aspect of the encapsulating device, the guide assembly has sheath deployment members that are disposed about the tissue specimen. The sheath, which is attached to ends of the sheath deployment members and the wand assembly, is drawn over the tissue specimen as the sheath deployment members are pushed or pulled. In another aspect of the device, the guide assembly is an arm or a housing that rotates about the tissue specimen. The sheath, which is secured at one end to the guide assembly and at another end to the wand assembly, is drawn over the tissue specimen as the guide assembly rotates. The sheath may be made up of porous material, non-porous material, selectively permeable material ...

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Номер записи: 81
04-05-2006 дата публикации

Methods and apparatus for securing medical instruments to desired locations in a patient's body

Номер: US20060094983A1
Автор: Fred Burbank, Paul Lubock, Michael Jones, Richard Quick
Принадлежит:

Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

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Номер записи: 82
14-05-2009 дата публикации

Methods for asymmetrical irradiation of a body cavity

Номер: US20090124845A1
Автор: Paul Lubock, Michael L. Jones, Frank R. Louw
Принадлежит: SENORX, INC.

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

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Номер записи: 83
20-03-2008 дата публикации

Temporary catheter for biopsy site tissue fixation

Номер: US20080071212A1
Автор: Paul Lubock, Michael Jones
Принадлежит: SenoRx, Inc.

Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. One embodiment of the catheter device includes an elongated shaft having a proximal shaft section which is flexible enough to be folded or coiled into a configuration for deployment within the patient. An alternate embodiment includes a catheter device having one or more detachable proximal shaft sections and having at least one one-way valve to restrict fluid flow of inflation fluid to flow to the balloon. After deployment of the catheter device completely within the patient, the opening through which the catheter device is deployed is closed, e.g. by sutures, adhesives and the like to minimize infection at the site. Within a few days or weeks after the tissue has been evaluated for cancer, the temporary catheter device may be removed from the patient. If cancer or pre-cancer cells are found in the specimen removed from the cavity, then a radiation balloon ...

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Номер записи: 84
19-08-2008 дата публикации

Treatment of a body cavity

Номер: US0007413539B2
Автор: Paul Lubock, Michael L. Jones, LUBOCK PAUL, JONES MICHAEL L, JONES MICHAEL L.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

Devices and methods are provided for controlled application of a treatment to tissue adjacent a body cavity, such as after removal of tissue, e.g. cancer. A device embodying features of the invention includes one or more radiation shielding components to control emitted radiation from a radiation source to minimize radiation damage to healthy portions of the body cavity. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location therein to seal the passageway leading to the body cavity. Methods for treating a body cavity include methods for delivering a radiation source to a body cavity while minimizing damaging irradiation of healthy tissue.

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Номер записи: 85
13-08-2019 дата публикации

Vascular occlusion devices and methods

Номер: US0010376267B2
Автор: Paul Lubock, Richard Quick, Robert Rosenbluth, Brian J. Cox, LUBOCK PAUL, QUICK RICHARD, ROSENBLUTH ROBERT, COX BRIAN J, Lubock, Paul, Quick, Richard, Rosenbluth, Robert, Cox, Brian J.
Принадлежит: Inceptus Medical, LLC, INCEPTUS MEDICAL LLC, Inceptus Medical LLC

A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle.

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Номер записи: 86
29-01-2013 дата публикации

Multilumen brachytherapy balloon catheter

Номер: US0008360950B2
Автор: George M. Acosta, Paul Lubock, ACOSTA GEORGE M, LUBOCK PAUL, ACOSTA GEORGE M.
Принадлежит: Senorx, Inc., SENORX INC, ACOSTA GEORGE M, LUBOCK PAUL, SENORX, INC., ACOSTA GEORGE M.

The disclosure describes a device for asymmetrical irradiation of a body cavity or site, such as after removal of tissue, e.g. biopsy or lumpectomy. The device includes an elongated tubular shaft having an inner lumen and a tubular wall with a plurality of lumens extending within the wall which are configured for receiving a radiation source. The distal portion of the tubular shaft is cut into a plurality of longitudinally separated wall segments with a lumen extending within at least one of the wall segments. A support member is positioned within the separated wall segments to support and position the wall segments in a desired configuration for brachytherapy. An expandable member such as an inflatable balloon is mounted on the distal shaft portion about the separated wall segments wall which when inflated secures the distal shaft portion within a desired intracorporeal site for brachytherapy treatment.

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Номер записи: 87
19-12-2002 дата публикации

Tissue acquisition system and method of use

Номер: US20020193705A1
Автор: Fred Burbank, Paul Lubock, Michael Jones, Martin Shabaz
Принадлежит: SenoRx, Inc.

A tissue acquisition system includes radio frequency (RF) cutter loops which are extendable out a cannula to cut cylindrical tissue samples from a tissue of interest in a patient. The cannula includes inner and outer cannulae which are mutually rotatable and include cutouts through which the cutting loop can be rotated and longitudinally extended to perform the cuts. The tissue samples are then aspirated proximally through the cannula for collection.

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Номер записи: 88
05-06-2012 дата публикации

Methods for asymmetrical irradiation of a body cavity

Номер: US0008192344B2
Автор: Paul Lubock, Michael L. Jones, Frank R. Louw, LUBOCK PAUL, JONES MICHAEL L, LOUW FRANK R, JONES MICHAEL L., LOUW FRANK R.
Принадлежит: Senorx, Inc., LUBOCK PAUL, JONES MICHAEL L, LOUW FRANK R, SENORX INC, JONES MICHAEL L., LOUW FRANK R., SENORX, INC.

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

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Номер записи: 89
26-06-2014 дата публикации

TISSUE SPECIMEN ISOLATING AND DAMAGING DEVICE AND METHOD

Номер: US20140180163A1
Автор: Fred H. Burbank, Paul Lubock, BURBANK FRED H, LUBOCK PAUL, BURBANK FRED H.
Принадлежит: SenoRx, Inc.

A device and method for treatment of a tissue specimen disposed in surrounding tissue includes isolating the tissue specimen from the surrounding tissue by using a separating device to sever and separate the tissue specimen from the surrounding tissue; damaging the isolated tissue specimen with a tissue specimen damaging device; and using an encapsulating device to encapsulate the isolated and damaged tissue specimen, the encapsulating device configured for operation independent from the separating device and the tissue specimen damaging device. 1. A process for operating a tissue collection apparatus having a separating device , a tissue specimen damaging device , and an encapsulating device , for collecting a tissue specimen disposed in surrounding tissue , comprising:isolating the tissue specimen from the surrounding tissue by using the separating device to sever and separate the tissue specimen from the surrounding tissue;damaging the isolated tissue specimen with the tissue specimen damaging device; andusing the encapsulating device to encapsulate the isolated and damaged tissue specimen, the encapsulating device configured for operation independent from the separating device and the tissue specimen damaging device.218-. (canceled)19. The process of claim 1 , wherein the act of damaging includes positioning wires adjacent the isolated tissue specimen and applying radiofrequency energy to the wires.20. The process of claim 19 , wherein the wires have a free end that is extendable from a retracted position in the tissue specimen damaging device to an extended position to engage the isolated tissue specimen.21. The process of claim 1 , wherein the act of damaging includes applying ionizing radiation to the isolated tissue specimen.22. The process of claim 1 , wherein the act of damaging includes one of a morcellating and a cutting of the isolated tissue specimen.23. The process of claim 1 , wherein the act of damaging includes applying thermal energy to the ...

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Номер записи: 90
24-02-2015 дата публикации

Cavity filling biopsy site markers

Номер: US0008965486B2
Автор: Fred H. Burbank, Paul Lubock, Michael L. Jones, BURBANK FRED H, LUBOCK PAUL, JONES MICHAEL L, BURBANK FRED H., JONES MICHAEL L.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360 cannula.

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Номер записи: 91
15-03-2018 дата публикации

DEPLOYMENT OF POLYSACCHARIDE MARKERS FOR TREATING A SITE WITHIN A PATIENT

Номер: US20180071048A1
Автор: Michael L. Jones, Paul Lubock
Принадлежит:

A tissue marker and tissue marking system is provided for treating and/or marking a site within a patient from which tissue has been removed. The tissue marker includes a press-formed marker body of 65% (by wt.) powder of corn starch or potato starch and 35% (by wt.) methylcellulose binder. 120-. (canceled)21. A tissue marker , comprising a press-formed marker body comprised of 65% (by wt.) powder of corn starch or potato starch and 35% (by wt.) methylcellulose binder.22. The tissue marker of claim 21 , wherein the powder has a particle size less than 0.01 inch.23. The tissue marker of claim 21 , wherein the powder has a particle size of about 10 to about 200 micrometers.24. The tissue marker of claim 21 , wherein the press-formed marker body has a transverse dimension of about 0.02 to about 0.1 inch.25. The tissue marker of claim 21 , wherein the press-formed marker body has a transverse dimension of about 0.035 to about 0.075 inch.26. The tissue marker of claim 21 , wherein the press-formed marker body has a length of about 0.1 to about 0.4 inch.27. The tissue marker of claim 21 , wherein the press-formed marker body has a length of about 0.15 to about 0.35 inch.28. The tissue marker of claim 21 , wherein the press-formed marker body has a pair of opposed flat surfaces and a pair of opposed convex surfaces claim 21 , the pair of opposed convex surfaces being orthogonal to the pair of opposed flat surfaces. This application is a continuation-in-part of U.S. patent application Ser. No. 12/070,786, entitled “DEPLOYMENT OF POLYSACCHARIDE MARKERS’, filed Feb. 21, 2008, which is a continuation-in-part of U.S. patent application Ser. No. 11/881,264, filed Jul. 26, 2007, which is related to and claims priority from provisional application Ser. No. 60/835,740, filed on Aug. 4, 2006.Also, this application is a continuation-in-part of U.S. patent application Ser. No. 13/155,628 entitled “FIBROUS MARKER AND INTRACORPOREAL DELIVERY THEREOF”, filed Jun. 8, 2011, which is a ...

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Номер записи: 92
11-02-2003 дата публикации

Apparatus and method for tissue capture

Номер: US0006517498B1
Автор: Fred H. Burbank, William C. Homet, Paul Lubock, BURBANK FRED H, HOMET WILLIAM C, LUBOCK PAUL, BURBANK FRED H., HOMET WILLIAM C.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

A tissue acquisition system includes electrodes that are energized by a radio frequency (RF) energy source. Retractable electrodes are energized and extended from a cannula and the cannula is advanced in the tissue to position the cannula near the target tissue site in a patient. The retractable electrodes are then retracted and a distal electrode cuts a tissue sample from the tissue site when the cannula is further advanced into the tissue. The retractable electrodes are then energized and extended from the cannula and the cannula is rotated to separate the tissue sample from the tissue site. The tissue sample is ejected through the cannula for collection by advancing a dilator.

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Номер записи: 93
12-02-2002 дата публикации

Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it

Номер: US0006347241B2
Автор: Fred H. Burbank, Paul Lubock, Michael L. Jones, Nancy Forcier, BURBANK FRED H, LUBOCK PAUL, JONES MICHAEL L, FORCIER NANCY, BURBANK FRED H., JONES MICHAEL L.
Принадлежит: SenoRx, Inc., SENORX INC, SENORX, INC.

A biopsy site marker comprises small bodies or pellets of gelatin which enclose substantially in their interior a radio (X-ray) opaque object. The gelatin pellets are deposited into the biopsy site, typically a cylindrical opening in the tissue created by the recent use of a vacuum assisted large core biopsy device, by an applicator device that includes an elongated cylindrical body that forms a flexible tube and a piston slidable in the tube. One end of the tube is placed into the biopsy site. Typically, several gelatin pellets, only some of which typically do, but all of which may contain the radio opaque object, are deposited sequentially into the site through the tube. The radio opaque objects contained in the gelatin bodies are of a non-biological configuration and readily identifiable as man-made object, so that in observation by typical mammography equipment they do not assume the shape of a line, whereby they are readily distinguishable from granules and lines of calcification.

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Номер записи: 94
14-08-2018 дата публикации

Device and method for treating vascular occlusion

Номер: US0010045790B2
Автор: Brian J. Cox, Paul Lubock, Robert F. Rosenbluth, COX BRIAN J, LUBOCK PAUL, ROSENBLUTH ROBERT F, Cox, Brian J., Lubock, Paul, Rosenbluth, Robert F.
Принадлежит: Inari Medical, Inc., INARI MEDICAL INC

A system and method for managing an occlusion, such as a blood clot, within a lumen or passageway of a patient. More particularly, a system and method for rapidly restoring blood flow through an occlusion including a self-expanding, tubular member through which blood may flow when in an expanded state. The tubular member has a structure configured to engage the occlusive material, thereby allowing for extraction of at least a portion of the occlusive material. The system may further employ a material extraction member that is deployed distally of the tubular member.

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Номер записи: 95
14-01-2010 дата публикации

Brachytherapy device with one or more toroidal balloons

Номер: US20100010287A1
Автор: Paul Lubock
Принадлежит: SenoRx, Inc.

The disclosure is directed to catheter devices and methods for controlled application of irradiation to tissue adjacent a body site, such as cavity after removal of tissue, e.g. cancer. The catheter device includes one or more inflatable, toroidal balloons on the distal shaft section of the device which surrounds and is spaced from one or more radiation guide members. Preferably at least one radiation guide members extend away from a central longitudinal axis to provide asymmetrical irradiation. Connecting members may extend between the radiation guide members and the toroidal balloon.

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Номер записи: 96
21-07-2005 дата публикации

Biopsy device with aperture orientation and improved tip

Номер: US20050159677A1
Автор: Martin Shabaz, Richard Quick, Frank Louw, Paul Lubock, Jason Safabash
Принадлежит:

The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component which is releasably secured to the driver component. The probe component has an elongated tubular section, a penetrating distal tip and a tissue receiving aperture in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The driver has drive members for operating the elements of the probe component. The tissue penetrating distal tip preferably has a triple concave curvature shape with three curved cutting edges leading to a sharp distal point.

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Номер записи: 97
18-08-2005 дата публикации

Vacuum device and method for treating tissue adjacent a body cavity

Номер: US20050182286A1
Автор: Paul Lubock
Принадлежит: SenoRx, Inc.

Devices and methods are provided for applying vacuum near to devices for delivering treatments to tissue adjacent a body cavity, effective to draw adjacent tissue near to such devices and to enhance treatment of the tissue. Body cavities include natural body cavities and cavities remaining after removal of tissue such as cancerous tissue. A device may include an inner balloon assembly with an inflation conduit. A sheath assembly having a fluid-permeable sheath wall may enclose the inner balloon assembly. Vacuum applied to the space between the sheath and the inner balloon is useful to draw tissue into contact with the device, improving treatment effectiveness. Methods for treating tissue with such devices and systems are also provided. Treatments may include providing radioactive material for radiation treatment, providing chemotherapeutic material for chemotherapy, providing thermal treatment, and combinations thereof. Systems may include devices of the invention and a vacuum source.

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Номер записи: 98
02-02-2012 дата публикации

TREATMENT OF A BODY CAVITY

Номер: US20120029262A1
Автор: Paul Lubock, Michael L. Jones, LUBOCK PAUL, JONES MICHAEL L, JONES MICHAEL L.
Принадлежит: SenoRx, Inc.

Devices and methods are provided for controlled application of a treatment to tissue adjacent a body cavity, such as after removal of tissue, e.g. cancer. A device embodying features of the invention includes one or more radiation shielding components to control emitted radiation from a radiation source to minimize radiation damage to healthy portions of the body cavity. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location therein to seal the passageway leading to the body cavity. Methods for treating a body cavity include methods for delivering a radiation source to a body cavity while minimizing damaging irradiation of healthy tissue. 1. A device for treating a body cavity within a patient , comprising:a.) a radiation delivery device, the radiation delivery device having an elongate shaft having a proximal end, a distal end, a plurality of lumens, and a treatment location in a distal portion of the shaft, the radiation delivery device being configured to provide an asymmetrical radiation delivery pattern to tissue surrounding the treatment location; andb.) a radiation source configured to be disposed in the treatment location.2. The device of claim 1 , wherein the elongate shaft has a cavity filling member which at least in part fills the body cavity and which surrounds at least in part the treatment location.3. The device of claim 1 , comprising a radiation shielding component configured to control at least in part the dispersal of radiation emitted from the radiation source claim 1 , wherein the radiation shielding component is slidably disposed within the elongate shaft.4. The device of claim 3 , wherein the radiation shielding component is configured to be deployed proximal to the treatment location.5. The device of claim 1 , comprising at least one radiation shielding component configured to control at least in part the dispersal of radiation emitted from the ...

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Номер записи: 99
17-05-2018 дата публикации

GRAPHICAL USER INTERFACE FOR TISSUE BIOPSY SYSTEM

Номер: US20180132752A1
Автор: Derek J. Daw, Frank R. Louw, Paul Lubock, Richard L. Quick, Martin V. Shabaz
Принадлежит:

A screen providing a graphical user interface (GUI) for a tissue biopsy system includes a circular area and a plurality of GUI areas of variable size located in the circular area. The plurality of GUI areas includes a first GUI area, a second GUI area, and a third GUI area. The first GUI area is configured to represent a first region of the target site from which at least one tissue specimen has been separated from tissue at the target site by a tissue cutting member. The second GUI area is configured to represent a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site. The third GUI area is configured to represent a third region in which the tissue cutting member is deployed to separate a tissue specimen from tissue at the target site. 141-. (canceled)42. A screen providing a graphical user interface (GUI) for a tissue biopsy system having a tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient , the screen having the graphical user interface comprising:a circular area; anda plurality of GUI areas of variable size located in the circular area, the plurality of GUI areas including:a. a first GUI area configured to represent a first region of the target site from which at least one tissue specimen has been separated from tissue at the target site by the tissue cutting member, the first GUI area having a plurality of portions, wherein at least one portion of the plurality of portions is a curvy band portion;b. a second GUI area, visually distinguishable from the first GUI area, configured to represent a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site; andc. a third GUI area, visually distinguishable from the first and second GUI areas, configured to represent a third region in which the tissue cutting member is deployed to separate a tissue ...

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Номер записи: 100
12-04-2012 дата публикации

Brachytherapy device for facilitating asymmetrical irradiation of a body cavity

Номер: US20120088952A1
Автор: Frank R. Louw, Michael L. Jones, Paul Lubock
Принадлежит: SenoRx Inc

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

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Номер записи: 101
23-08-2012 дата публикации

PLUGGED TIP DELIVERY TUBE FOR MARKER PLACEMENT

Номер: US20120215230A1
Автор: Lubock Paul, Merritt John, Safabash Jason H., Shabaz Martin
Принадлежит:

An intracorporeal marker delivery device includes a delivery tube which has a distal tip, a discharge orifice and an inner bore extending to the discharge orifice. A plug is releasably secured within the inner bore. The plug may itself serve as a marker, and may be the sole marker. Markers may be positioned proximal to the plug, and may be detectable by ultrasound, X-ray, magnetic resonance imaging, and other imaging devices, and may include bioactive elements. 1. An intracorporeal marker delivery device comprising:a delivery tube which has a distal tip, a discharge orifice and an inner bore extending to the discharge orifice;at least one marker which is slidably disposed within the inner bore; anda plug, releasably secured within the inner bore distal to the at least one marker, the plug having an internal gap adjacent an end portion of the plug configured to reduce a lateral dimension of the plug when the plug is inserted into the inner bore.249-. (canceled)50. The intracorporeal marker delivery device of claim 1 , wherein the plug is formed at least in part of imagable marker material.51. The intracorporeal marker delivery device of claim 1 , wherein the end portion of the plug is a proximally diverging plug portion claim 1 , and the gap extends from a proximal end of the plug into the proximally diverging plug portion claim 1 , the proximally diverging plug portion being configured to resiliently engage the delivery tube within the inner bore.52. The intracorporeal marker delivery device of claim 51 , wherein the gap extends from the proximal end of the plug to a terminal expanded opening within the plug.53. The intracorporeal marker delivery device of claim 1 , wherein the end portion of the plug is a distally diverging plug portion claim 1 , and the gap extends from a distal end of the plug into the distally diverging plug portion claim 1 , the distally diverging plug portion being configured to resiliently engage the delivery tube at the inner bore.54. The ...

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Номер записи: 102
01-11-2012 дата публикации

METHODS AND APPARATUS FOR SECURING MEDICAL INSTRUMENTS TO DESIRED LOCATIONS IN A PATIENT'S BODY

Номер: US20120277626A1
Автор: Burbank Fred H., Jones Michael L., Lubock Paul, Quick Richard L.
Принадлежит:

A medical device for localization of tissue at a target site in a patient's body includes a tube having a distal end, a proximal end, and a longitudinal axis. The medical device is configured for placement of the distal end at the target site. A fixation device is disposed on the distal end. The affixation device is configured to mechanically fix the distal end of the medical device to tissue at the target site. 1. A medical device for localization of tissue at a target site in a patient's body , comprising:a tube having a distal end, a proximal end, and a longitudinal axis, the medical device being configured for placement of said distal end at the target site; anda fixation device disposed on said distal end, the fixation device being configured to mechanically fix the distal end of said medical device at the target site without penetrating tissue surrounding the target site.248-. (canceled)49. The medical device of claim 1 , wherein the fixation device is a Mallicot structure having a plurality of expandable elongate bands arranged circumferentially around the longitudinal axis.50. The medical device of claim 49 , further comprising a plurality of actuating pushrods arranged circumferentially with respect to the longitudinal axis and configured to actuate the plurality of expandable elongate bands between the retracted configuration and the expanded configuration.51. The medical device of claim 49 , wherein each of the plurality of expandable elongate bands is contracted to provide a radial expansion of the Mallicot structure.52. The medical device of claim 1 , wherein the fixation device is a radially expandable linkage having a plurality of linkage elements and a plurality of linkage pivot points.53. The medical device of claim 1 , wherein the fixation device is a radially expandable basket structure formed by a plurality of longitudinally extending curved elements arranged circumferentially around the longitudinal axis.54. A medical device for localization of ...

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Номер записи: 103
01-11-2012 дата публикации

POROUS BIOABSORBABLE IMPLANT

Номер: US20120277859A1
Автор: Govil Amit, Jones Michael L., Lubock Paul
Принадлежит:

An implant for insertion into a breast lumpectomy cavity to serve as a guide for orienting a radiation source relative to the breast lumpectomy cavity, includes a body formed of a bioabsorbable material comprised of chitosan having a porosity sufficient to ensure tissue in-growth before significant bio-absorption of the implant, the body having exterior margins. An interior orientation marker is spaced inwardly from the exterior margins of the body to facilitate relative orientation between the implant and the radiation source. 1. An implant for insertion into a breast lumpectomy cavity to serve as a guide for orienting a radiation source relative to the breast lumpectomy cavity , comprising:a body formed of a bioabsorbable material comprised of chitosan having a porosity sufficient to ensure tissue in-growth before significant bio-absorption of the implant, the body having exterior margins; andan interior orientation marker spaced inwardly from the exterior margins of the body to facilitate relative orientation between the implant and the radiation source.2. The implant of wherein the orientation marker comprises a plurality of radiopaque elements spaced inwardly from the exterior margins of the implant in a predefined pattern.3. The implant of wherein the implant has a spongy consistency claim 1 , and wherein a hardness of the implant is determined by an amount of the chitosan in the implant.4. The implant of wherein the bioabsorbable material has an in vivo life of at least two weeks but not more than about twenty weeks.5. (canceled)6. The implant of comprising a radiopaque imaging agent located at the exterior margins to facilitate imaging of the exterior margins of the implant claim 1 , the radiopaque imaging agent being selected from the group consisting of Barium Sulfate claim 1 , Barium Carbonate claim 1 , Silver Chloride claim 1 , Silver Iodide claim 1 , Silver Nitrate claim 1 , Calcium Carbonate and Zinc Oxide.7. The implant of comprising a plurality of ...

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Номер записи: 104
06-12-2012 дата публикации

METHODS FOR ASYMMETRICAL IRRADIATION OF A BODY CAVITY

Номер: US20120310032A1
Автор: Jones Michael L., Louw Frank R., Lubock Paul
Принадлежит:

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity. 1. An apparatus for treating tissue surrounding a body cavity of a patient with a radiation source , comprising:an elongate outer catheter having a distal end, a treatment portion proximal the distal end, and a first lumen configured to extend into the treatment portion; andan elongate inner catheter positioned in the first lumen of the outer catheter, the elongate inner catheter having a longitudinal axis and an off-set lumen off-set from the longitudinal axis, the elongate inner catheter being configured to extend within the first lumen into the treatment portion of the elongate outer catheter and configured rotate relative to the elongate outer catheter about the longitudinal axis, the off-set lumen of the elongate inner catheter being configured to receive the radiation source.26-. (canceled)7. The apparatus of claim 1 , comprising an inflatable member coupled to the outer elongate catheter and positioned to surround the treatment portion.8. The apparatus of claim 7 , wherein the elongate outer catheter has an annular wall and an inflation lumen located in the annular wall claim 7 , the inflation lumen being configured in fluid communication with an interior of the inflatable member.9. The apparatus of claim 8 , comprising:a first vacuum port located in the elongate outer cannula proximal to the inflatable member and configured in fluid communication with a region exterior to the elongate outer cannula; anda first vacuum lumen located in the annular wall, and configured in fluid ...

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Номер записи: 105
03-01-2013 дата публикации

Tissue irradiation

Номер: US20130006037A1
Автор: Michael L. Jones, Paul Lubock
Принадлежит: SenoRx Inc

Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity.

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Номер записи: 106
28-03-2013 дата публикации

BIOPSY DEVICE WITH FLUID DELIVERY TO TISSUE SPECIMENS

Номер: US20130079664A1
Автор: Louw Frank R., Lubock Paul, Quick Richard L., Safabash Jason H., Shabaz Martin V.
Принадлежит: SenoRx, Inc.

The invention is directed to a system and method for separating and collecting one or more tissue specimens from a target site within a patient and flushing the specimen to remove blood, debris and the like before the specimen is removed from the biopsy device. The flow of flushing fluid to the tissue collector is preferably controlled to coincide with delivery of one or more specimens to the collecting tray or basket of the device or after the receipt of the specimen within the tissue collector to ensure that the fluid is applied to a fresh specimen. The tissue tray or basket within the tissue collector has an open or foraminous portion to facilitate removal of fluid, such as the applied fluid and blood, and other debris from the tissue specimens on the tray. Vacuum is provided within the tissue collector, preferably under the tray to remove fluid and debris from the collector interior. 1. A system for collecting one or more tissue specimens from a target site within a patient , comprising: a distal shaft portion with a distal tip, a tubular section proximal to the distal tip, an inner lumen extending within the tubular section and a tissue receiving aperture in the tubular section which provides access to tissue at the target site, and', 'an elongated tissue cutting member which has at least one tissue cutting edge;, 'an elongated probe component includinga collector housing defining an interior, and having a proximal opening and a distal port opposite the proximal opening, the distal port of the collector housing being configured to receive a proximal end of the elongated probe component such that the proximal end of the elongated probe component can extend into the interior of the collector housing; and a first end portion; and', 'a grated portion that extends from the first end portion, the grated portion being configured to extend through the proximal opening of the collector housing in a direction toward the distal port and into the interior to separate the ...

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Номер записи: 107
16-05-2013 дата публикации

TEMPORARY CATHETER FOR BIOPSY SITE TISSUE FIXATION

Номер: US20130123831A1
Автор: Jones Michael L., Lubock Paul
Принадлежит: SenoRx, Inc.

Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. A catheter for temporarily at least partially filing a body cavity in a targeted tissue region within a patient's body includes a shaft having a distal end, a proximal end, and a cavity filling member on a distal shaft section configured to at least partially fill the body cavity. A proximal shaft section is configured to be folded so as to be subcutaneously deployed within the patient when the cavity filling member is disposed within the body cavity so as to prevent intrusion of bacteria. An anti-bacterial material is applied to or incorporated within a surface of the shaft and the cavity filling member so as to prevent bacteria growth. 1. A catheter for temporarily at least partially filling a body cavity in a targeted tissue region within a patient's body comprising:a. a shaft having a distal end, a proximal end, and a cavity filling member on a distal shaft section configured to at least partially fill the body cavity;b. a proximal shaft section configured to be folded so as to be subcutaneously deployed within the patient when the cavity filling member is disposed within the body cavity so as to prevent intrusion of bacteria; andc. an anti-bacterial material applied to or incorporated within a surface of the shaft and the cavity filling member so as to prevent bacteria growth.2. The catheter of claim 1 , wherein the cavity filling member is an inflatable balloon.3. The catheter of claim 2 , comprising an inflation lumen that extends along the catheter shaft between the proximal end and the inflatable balloon and configured to direct inflation fluid to the interior of the balloon.4. The catheter of claim 1 , comprising at least one vacuum lumen that extends along the catheter shaft to a vacuum port proximal or distal to the cavity filling member.5. The catheter of wherein the proximal shaft section is formed of a compliant or ...

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Номер записи: 108
06-06-2013 дата публикации

MULTILUMEN BRACHYTHERAPY BALLOON CATHETER

Номер: US20130144105A1
Автор: Acosta George M., Lubock Paul
Принадлежит: SenoRx, Inc.

The disclosure describes a device for asymmetrical irradiation of a body cavity or site, such as after removal of tissue, e.g. biopsy or lumpectomy. The device includes an elongated tubular shaft having an inner lumen and a tubular wall with a plurality of lumens extending within the wall which are configured for receiving a radiation source. The distal portion of the tubular shaft is cut into a plurality of longitudinally separated wall segments with a lumen extending within at least one of the wall segments. A support member is positioned within the separated wall segments to support and position the wall segments in a desired configuration for brachytherapy. An expandable member such as an inflatable balloon is mounted on the distal shaft portion about the separated wall segments wall which when inflated secures the distal shaft portion within a desired intracorporeal site for brachytherapy treatment. 18-. (canceled)9. A brachytherapy device for irradiating tissue surrounding a body cavity within a patient , comprising:an elongated shaft having a inner lumen, a wall at least in part defining the inner lumen, a plurality of lumens within the wall and a central longitudinal axis;a distal shaft portion having a treatment location and a plurality of longitudinally separated wall segments, with at least one of the longitudinally wall segments having a lumen extending therein configured to receive a radiation source;a support member configured to support the plurality of longitudinally separated wall segments in off-set positions relative to the central longitudinal axis, wherein the support member has an inner lumen which is in fluid communication with the inner lumen defined by the wall of the elongated shaft; anda central tubular member received in the inner lumen of the elongated shaft and received in the inner lumen of the support member and configured to direct the radiation source through the support member to the treatment location.10. The device of claim 9 , ...

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Номер записи: 109
06-06-2013 дата публикации

MARKER DELIVERY DEVICE WITH RELEASABLE PLUG

Номер: US20130144157A1
Автор: Jones Michael L., Lubock Paul, Merritt John
Принадлежит: SenoRx, Inc.

A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body includes a plurality of bioabsorbable polymeric strands. The strands are compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula. 1. A marker delivery device for an intracorporeal tissue site , comprising:an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen; andat least one elongated fibrous marker body slidably disposed within the inner lumen of the elongated delivery cannula, the at least one elongated fibrous marker body comprising a plurality of bioabsorbable polymeric strands, said strands being compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula.210-. (canceled)11. The marker delivery device of claim 1 , comprising a radiographically detectable element positioned to surround an exterior portion of a respective fibrous marker body of the at least one elongated fibrous marker body.12. The marker delivery device of claim 1 , wherein the at least one fibrous marker body comprises fibers of oxidized cellulose.13. The marker delivery device of claim 1 , wherein the at least one fibrous marker body comprises fibers of oxidized regenerated cellulose.14. The marker delivery device of claim 1 , wherein the at least one elongated fibrous marker body comprises bioabsorbable fibers of polymeric material selected from the group consisting of polylactic acids ...

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Номер записи: 110
08-08-2013 дата публикации

Aneurysm Graft Devices And Methods

Номер: US20130204351A1
Автор: Cox Brian J., Lubock Paul, Rosenbluth Robert F.
Принадлежит: Inceptus Medical LLC

The present invention provides methods and apparatus for the endoluminal positioning of an intraluminal prosthesis at a target location within a body lumen. The device may comprise a porous, multi-layer prosthesis that can include several different tubular mesh components such as an everted tubular component, an tubular component that expands to various different sizes, a bifurcated tubular component, and a tubular component with an undulating expanded shape, among others. Various components can have different densities or pore sizes and can be overlaid on each other to selectively block different regions of a vessel. 1. A vascular defect treatment prosthesis , comprising:a first porous tubular component forming a first prosthesis layer expandable against a vessel;a second porous tubular component forming a second prosthesis layer expandable against said first porous tubular component; said second porous tubular component being discrete from said first porous tubular component such that said second porous tubular component is consecutively deliverable after said first porous tubular component.2. The prosthesis of claim 1 , wherein said first tubular component further comprises an everted portion forming a torus shape around a non-everted cylindrical portion.3. The prosthesis of claim 1 , wherein said first porous tubular component comprises a first cylindrical portion and a second portion having a first fold directed radially outward from said first cylindrical portion so as to create an annular cavity around said first cylindrical portion.4. The prosthesis of claim 3 , wherein said second portion comprises a second fold directed radially inward such that an end of said first porous tubular component is located adjacent to said first fold.5. The prosthesis of claim 1 , wherein said second porous tubular component further comprises a cylindrical shape.6. The prosthesis of claim 1 , wherein said second porous tubular component further comprises a cylindrical shape ...

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Номер записи: 111
26-09-2013 дата публикации

Marker or filler forming fluid

Номер: US20130253315A1
Автор: Frank Louw, Fred H. Burbank, Michael L. Jones, Paul Lubock
Принадлежит: SenoRx Inc

A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A marker is configured to be delivered to the cavity from the distal end of the delivery tube and is configured to remain with the porous bioabsorbable body within the cavity upon the formation thereof.

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Номер записи: 112
24-10-2013 дата публикации

INTRACORPOREAL MARKER AND MARKER DELIVERY DEVICE

Номер: US20130281847A1
Автор: Jones Michael L., Lubock Paul, Merritt John
Принадлежит:

An intracorporeal marker system includes a tissue marker pellet comprised of a polysaccharide material. The intracorporeal marker system may also include a fibrous marker of bioabsorbable fibers. In one embodiment, for example, an outer layer of bioabsorbable fibers is disposed around at least part of an inner core of bioabsorbable fibers. 1. An intracorporeal marker system , comprising:an elongated intracorporeal marker having an inner core of bioabsorbable fibers and an outer layer of bioabsorbable fibers disposed around at least part of the inner core; anda tissue marker pellet comprised of a polysaccharide material.220-. (canceled)21. The intracorporeal marker system of claim 1 , comprising a plurality of polysaccharide marker pellets.22. The intracorporeal marker system of claim 1 , comprising:an elongated tubular shaft which has a distal end, a proximal end, an inner lumen extending between the proximal end and the distal end, and a distal discharge opening, wherein each of the elongated intracorporeal marker and the tissue marker pellet being disposed in the inner lumen prior to delivery to a delivery site in a patient; anda plunger element slidably disposed in part within the inner lumen of the elongated tubular shaft proximal to each of the elongated intracorporeal marker and the tissue marker pellet.23. A remotely imageable marker system for an intracorporeal site claim 1 , comprising a first tissue marker pellet comprised of a polysaccharide configured to exhibit hemostatic properties.24. The remotely imageable marker system of claim 23 , further comprising a radiopaque element disposed within the first tissue marker pellet.25. The remotely imageable marker system of claim 23 , further comprising a fibrous marker comprising bioabsorbable fibers.26. The remotely imageable marker system of claim 23 , comprising:an elongated tubular shaft which has a distal end, a proximal end, an inner lumen extending between the proximal end and the distal end, and a ...

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Номер записи: 113
21-11-2013 дата публикации

Fibrous marker and intracorporeal delivery thereof

Номер: US20130310686A1
Автор: Lloyd H. Malchow, Michael L. Jones, Paul Lubock
Принадлежит: SenoRx Inc

An intracorporeal marker includes a fibrous unitary marker body having bioabsorbable fibers compressed into a compressed configuration, and bound in the compressed configuration by a polymer binding agent. The intracorporeal marker may be incorporated into an intracorporeal marker delivery device having a delivery cannula which has a distal tip, an inner lumen and a discharge opening in communication with the inner lumen. The compression and binding occur prior to insertion of the fibrous unitary marker body into the inner lumen of the delivery cannula. The fibrous unitary marker body is slidably disposed within and pushable through the inner lumen of the elongated delivery cannula proximal to the discharge opening.

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Номер записи: 114
02-01-2014 дата публикации

Multilayered expandable braided devices and methods of use

Номер: US20140005714A1
Автор: Brian J. Cox, Paul Lubock, Richard Quick, Robert Rosenbluth
Принадлежит: Inceptus Medical LLC

Devices and methods for occluding blood flow into a body cavity are disclosed herein. An occlusion device can include an expandable lattice structure having an occlusive braid and a structural braid. In some embodiments, the structural braid is enveloped by the occlusive braid, and the occlusive braid is configured to contact and seal with tissue. The structural braid can have a first pick angle and the occlusive braid can have a second pick angle that is greater than the first pick angle. In some embodiments, the occlusion device is configured to occlude the left atrial appendage.

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Номер записи: 115
06-02-2014 дата публикации

BIOPSY DEVICE WITH INNER CUTTING MEMBER

Номер: US20140039344A1
Автор: Louw Frank R., Lubock Paul, Quick Richard L., Shabaz Martin V.
Принадлежит: SenoRx, Inc.

The invention is directed to devices and methods for separating and collecting a tissue specimen from a patient's target site. The device includes a probe member with a penetrating distal tip and a tissue receiving aperture, and a tissue cutting member which is rotatable disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture. The longitudinal edges of the aperture are preferably sharpened to engage the cutting edges of the tissue cutting member. Vacuum may be provided in the inner lumen of the cutting member to transport tissue therethrough. Rotation, rotational oscillation and/or longitudinal reciprocation of the tissue cutting member is effective to separate a tissue specimen from surrounding tissue. An accessing cannula having an tissue receiving aperture may be concentrically disposed within the probe member and about the tissue cutting member. The tissue cutting edge of the tissue cutting member preferably is longitudinally oriented and may have a cutting angle less than 90° with respect to the longitudinal axis of the tissue cutting member. 151-. (canceled)52. A tissue biopsy device for accessing and severing a tissue specimen from supporting tissue at a target site within a patient , comprising:a. an elongated probe member which has a longitudinal axis, an inner lumen extending therein, a tissue penetrating distal tip, and a tissue receiving aperture proximal to the tissue penetrating distal tip and defined at least in part by one longitudinally oriented, tissue cutting edge; andb. an elongated tissue cutting member disposed within the inner lumen of the elongated probe member and configured for cutting movements therein, which has a distal portion with a tissue cutting edge radially spaced from and is at least in part oriented at an acute cutting angle with respect to the at least one tissue cutting edge defining in part the tissue receiving aperture of the elongated probe member, and which is ...

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Номер записи: 116
03-04-2014 дата публикации

CAVITY FILLING BIOPSY SITE MARKERS

Номер: US20140094698A1
Автор: Burbank Fred H., Jones Michael L., Lubock Paul
Принадлежит: SenoRx, Inc.

The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula. 172-. (canceled)73. A marking system , comprising:a delivery; andan ultrasound-detectable biopsy marker carried by the delivery tube, the ultrasound-detectable biopsy marker formed of particles of material having internal bubble cavities and having a particle size less than about 800 microns.7475-. (canceled)76. The marking system of claim 73 , wherein the ultrasound-detectable biopsy marker is a bio-resorbable powder mass having a volume of between about 0.2 ml and about 1.2 ml of powder.77. The marking system of claim 73 , wherein the particle size is between about 200 microns and about 500 microns claim 73 , and the bubble cavities have a size of at least 50 microns claim 73 , wherein the bubble cavities have geometric centers and the bubble cavity size is measured by length through the geometric centers of the bubble cavities.78. The marking system of claim 73 , wherein the material comprises a bio-resorbable polymeric material and the particle size is between about 200 microns and about 500 microns.79. The marking system of claim 73 , wherein at least a ...

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Номер записи: 117
01-01-2015 дата публикации

EXPANDABLE OCCLUSION DEVICES AND METHODS OF USE

Номер: US20150005811A1
Автор: Cox Brian J., Lubock Paul, Quick Richard, Rosenbluth Michael J., Rosenbluth Robert
Принадлежит:

Devices and methods for occluding the left atrial appendage are disclosed herein. An occlusion device can include an expandable lattice structure having a proximal portion configured to be positioned at or near the ostium of the LAA, a distal portion configured to extend into an interior portion of the LAA, and a contact portion between the proximal and distal portions. In several embodiments, the expandable lattice structure includes an occlusive braid configured to contact and seal with tissue of the LAA and a structural braid enveloped by the occlusive braid. The structural braid can be coupled to the occlusive braid at a proximal hub located at the proximal portion of the lattice structure. The structural braid is configured to drive the occlusive braid radially outward. The occlusive braid can have an atrial face at the proximal portion facing the left atrium LA, and the atrial face can have a low-profile contour that mitigates thrombus formation at the atrial face. 1. A device for occluding a left atrial appendage (“LAA”) , wherein the LAA is open to a left atrium at an ostium of the LAA , the device comprising: an occlusive braid configured to contact and seal with tissue of the LAA;', 'a structural braid enveloped by the occlusive braid and coupled to the occlusive braid at a proximal hub located at the proximal region of the lattice structure; and, 'an expandable lattice structure having a proximal region configured to be positioned at or near the ostium of the LAA, a distal region configured to extend into an interior portion of the LAA, and a contact region therebetween, wherein the expandable lattice structure includes—'}wherein the structural braid is configured to drive the occlusive braid radially outward to press the occlusive braid against the tissue of the LAA at and/or distal to the ostium.2. The device of wherein the lattice structure has an atrial face at the proximal region facing the left atrium and the atrial face has a low-profile contour ...

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Номер записи: 118
27-01-2022 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20220022898A1
Автор: Cox Brian J., Lubock Paul, MARCHAND Philippe, Quick Richard, Rosenbluth Robert
Принадлежит:

A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member having a plurality of first clot engagement members and second clot engagement members positioned about the circumference of a distal portion of the support member. In an undeployed state, individual first clot engagement members can be linear and have a first length, and individual second clot engagement members can be linear and have a second length that is less than the first length. The clot engagement members can be configured to penetrate clot material along an arcuate path and hold clot material to the clot treatment device. 120-. (canceled)21. A method of treating clot material in a blood vessel , the method comprising:advancing a clot treatment device in a low-profile state through a lumen of a guide catheter, wherein the clot treatment device includes a mesh structure and a plurality of treatment portions;at least partially expanding the clot treatment device within the blood vessel from the low-profile state to a deployed state, wherein individual ones of the treatment portions include a proximally-facing curved portion and a distally-facing curved portion in the deployed state;expanding a funnel member within the blood vessel proximal of the clot material;engaging the clot treatment device with the clot material;retracting the clot treatment device and a portion of the clot material into a distal portion of the guide catheter; andinhibiting, with the funnel member, the clot material from moving proximally through the blood vessel past the distal portion of the guide catheter during retraction of the clot treatment device and the portion of the clot material into the distal portion of the guide catheter.22. The method of wherein the method further comprises aspirating the guide catheter.23. The method of ...

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Номер записи: 119
03-02-2022 дата публикации

VASCULAR OCCLUSION DEVICES AND METHODS

Номер: US20220031335A1
Автор: Cox Brian J., Lubock Paul, Quick Richard, Rosenbluth Robert
Принадлежит:

A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle. 1. A device for embolizing a blood vessel , comprising:a mesh structure including a plurality of filaments braided together, wherein the mesh structure is configured to radially expand from a compressed state to an expanded state within the blood vessel;wherein, in the compressed state, the mesh structure has a generally cylindrical shape; and the mesh structure includes a plurality of radially extending regions,', 'individual ones of the radially extending regions include an apex configured to contact a wall of the blood vessel,', 'each of the apices has a thickness along a longitudinal axis of the device, and', 'the combined thicknesses of the apices is less than about 50% of a total length of the mesh structure along the longitudinal axis., 'wherein, in the expanded state—'}2. The device of wherein the filaments are each formed from a shape-memory material.3. The device of wherein the filaments are generally flexible.4. The device of wherein the radially extending regions are porous and configured to impede blood flow through the ...

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Номер записи: 120
21-01-2016 дата публикации

DEPLOYMENT OF POLYSACCHARIDE MARKERS FOR TREATING A SITE WITHIN A PATIENT

Номер: US20160015475A1
Автор: Jones Michael L., Lubock Paul
Принадлежит:

A method for treating a site within a patient from which tissue has been removed includes providing at least one press-formed marker body formed of polysaccharide and a suitable binder; and placing the at least one of the press-formed marker body within the site where tissue has been removed so as to provide hemostasis therein. 120-. (canceled)21. A tissue marker , comprising a press-formed marker body comprised of 65% (by wt.) powder of corn starch or potato starch and 35% (by wt.) methylcellulose binder.22. The tissue marker of claim 21 , wherein the powder has a particle size less than 0.01 inch.23. The tissue marker of claim 21 , wherein the powder has a particle size of about 10 to about 200 micrometers.24. The tissue marker of claim 21 , wherein the press-formed marker body has a transverse dimension of about 0.02 to about 0.1 inch.25. The tissue marker of claim 21 , wherein the press-formed marker body has a transverse dimension of about 0.035 to about 0.075 inch.26. The tissue marker of claim 21 , wherein the press-formed marker body has a length of about 0.1 to about 0.4 inch.27. The tissue marker of claim 21 , wherein the press-formed marker body has a length of about 0.15 to about 0.35 inch.28. The tissue marker of claim 21 , wherein the press-formed marker body has a pair of opposed flat surfaces and a pair of opposed convex surfaces claim 21 , the pair of opposed convex surfaces being orthogonal to the pair of opposed flat surfaces.29. A system for delivery of at least one tissue marker to a site within a patient claim 21 , comprising:a marker delivery device having a delivery tube with an inner lumen and a discharge port, and a plunger slidably disposed within the inner lumen of the delivery tube, the plunger having a proximal end and a distal end, the proximal end having a head configured to allow an operator to move the plunger within the inner lumen; anda press-formed marker body disposed in the inner lumen distal to the distal end of the plunger, ...

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Номер записи: 121
15-01-2015 дата публикации

Methods and apparatus for treating pulmonary embolism

Номер: US20150018859A1
Автор: Brian J. Cox, Paul Lubock, Richard Quick, Robert F. Rosenbluth
Принадлежит: Inceptus Medical LLC

A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member configured to extend through a delivery catheter and a plurality of clot engagement members positioned about the circumference of a distal portion of the support member. The individual clot engagement members can have a first portion and a second portion extending from the first portion, and the first portions can have a proximal region attached to the support member. In the deployed state, the individual second portions can extend from the distal region of one of the first portions and project radially outwardly relative to the support member in a curve that has a proximally extending section which defines a proximally facing concave portion.

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Номер записи: 122
15-01-2015 дата публикации

Methods and apparatus for treating small vessel thromboembolisms

Номер: US20150018860A1
Автор: Brian J. Cox, Paul Lubock, Richard Quick, Robert F. Rosenbluth
Принадлежит: Inceptus Medical LLC

A device and method for intravascular treatment of an embolism, and particularly an embolism within a small vessel, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member configured to extend through a delivery catheter and a plurality of clot engagement members positioned about the circumference of a distal portion of the support member. The individual clot engagement members can have a first portion and a second portion extending from the first portion, and the first portions can have a proximal region attached to the support member. In the deployed state, the individual second portions can extend from the distal region of one of the first portions and project radially outwardly relative to the support member in a curve that has a proximally extending section which defines a proximally facing concave portion.

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Номер записи: 123
24-01-2019 дата публикации

BIOPSY DEVICE WITH APERTURE ORIENTATION AND IMPROVED TIP

Номер: US20190021705A1
Автор: Louw Frank R., Lubock Paul, Quick Richard L., Safabash Jason H., Shabaz Martin V.
Принадлежит:

A biopsy device includes an elongated probe having a central longitudinal axis, a proximal end, and a distal end. A tissue penetrating tip includes a proximal base and a sharp distal point. The proximal base is secured to the distal end of the elongated probe. The sharp distal point is distal to the proximal base and is aligned with the central longitudinal axis. The tissue penetrating tip has a plurality of concave surfaces annularly arranged to form at least three adjacent pairs of concave surfaces. Each concave surface of the plurality of concave surfaces extends from the proximal base to the sharp distal point. Each adjacent pair of concave surfaces intersect to form a concave curved cutting edge. Cumulatively, the at least three adjacent pairs of concave surfaces form a plurality of concave curved cutting edges that distally terminate at the sharp distal point. 169-. (canceled)70. A biopsy device , comprising:an elongated probe having a central longitudinal axis, a proximal end, and a distal end; anda tissue penetrating tip that includes a proximal base and a sharp distal point, the proximal base being secured to the distal end of the elongated probe, the sharp distal point being distal to the proximal base and aligned with the central longitudinal axis,the tissue penetrating tip having a plurality of concave surfaces annularly arranged to form at least three adjacent pairs of concave surfaces,wherein each concave surface of the plurality of concave surfaces extends from the proximal base to the sharp distal point, wherein each adjacent pair of concave surfaces intersect to form a concave curved cutting edge, and cumulatively, the at least three adjacent pairs of concave surfaces form a plurality of concave curved cutting edges that distally terminate at the sharp distal point.71. The biopsy device of claim 70 , further comprising a cutting cannula that is coaxial with the elongated probe.72. The biopsy device of claim 70 , wherein the at least three adjacent ...

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Номер записи: 124
28-01-2021 дата публикации

POROUS BIOABSORBABLE IMPLANT

Номер: US20210023278A1
Автор: Govil Amit, Jones Michael L., Lubock Paul
Принадлежит:

A method for forming a porous implant suitable for a cavity from which tissue has been removed includes incorporating a gas or a pore forming agent into an alginate solution; transferring the alginate solution with the gas or the pore forming agent into a solidified body mold having a desired shape with an outer surface; removing the water from the solidified body; and subjecting the solidified body to a conversion solution to convert the outer surface to a less soluble alginate creating a composition comprising the outer surface having less soluble alginate and a core having more soluble alginate. 122-. (canceled)23. A method for forming a porous implant suitable for a cavity from which tissue has been removed , comprising:a. incorporating a gas or a pore forming agent into an alginate solution;b. transferring the alginate solution with the gas or the pore forming agent into a solidified body mold having a desired shape with an outer surface;c. removing the water from the solidified body; andd. subjecting the solidified body to a conversion solution to convert the outer surface to a less soluble alginate creating a composition comprising the outer surface having the less soluble alginate and a core having a more soluble alginate.24. The method of claim 23 , comprising inserting an orientation marker into the body claim 23 , the orientation marker being spaced inwardly from exterior margins of the implant.25. The method of claim 23 , comprising inserting a plurality of radiopaque elements in an orientation lying in a plane into the body.26. The method of claim 23 , wherein the water removing step comprises freeze drying.27. The method of claim 23 , wherein the more soluble alginate is sodium alginate.28. The method of claim 27 , wherein the less soluble alginate is calcium alginate.29. The method of claim 28 , further comprising incorporating a starch in finely divided particulate form into the alginate solution so that when the calcium alginate is formed claim 28 , ...

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Номер записи: 125
04-02-2016 дата публикации

Aneurysm Graft With Stabilization

Номер: US20160030155A1
Автор: Cox Brian J., Lubock Paul, Rosenbluth Robert F.
Принадлежит: Inceptus Medical LLC

The present invention provides methods and apparatus for the endoluminal positioning of an intraluminal prosthesis at a target location within a body lumen. The device may comprise a porous, multi-layer prosthesis that can include stabilization members for stabilizing the placement of the device at the site. Various components can have different densities or pore sizes. 1. A vascular defect treatment device , comprising:an inner tubular member sized to span a vascular defect;at least one stabilization member associated with said tubular member and disposed so as to provide support to said inner tubular member in a region of said vascular defect.24-. (canceled)5. A vascular defect treatment device according to claim 1 , wherein said at least one stabilization member comprises two stabilization members disposed opposite each other along an axis of said inner tubular member.6. A vascular defect treatment device according to claim 5 , wherein opposing ends of said two stabilization members contact each other so as to form a ring of contact around said inner tubular member.7. A vascular defect treatment device according to claim 6 , wherein said ring of contact is substantially planar and is substantially orthogonal to said axis of said inner tubular member.8. A vascular defect treatment device according to claim 6 , wherein said ring of contact is substantially planar and is at an angle to the axis of said inner tubular member.9. A vascular defect treatment device according to claim 5 , wherein opposing ends of said two stabilization members are spaced from each other so as to create an axial space around said inner tubular member.10. (canceled)11. A vascular defect treatment device according to claim 1 , wherein said at least one stabilization member comprises three stabilization members disposed axially along said axis of said inner tubular member.12. A vascular defect treatment device according to claim 11 , wherein opposing ends of said three stabilization members ...

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Номер записи: 126
01-05-2014 дата публикации

BIOPSY SYSTEM WITH INTEGRATED IMAGING

Номер: US20140121504A1
Автор: Daw Derek, Lubock Paul, Malchow Lloyd H.
Принадлежит: SenoRx, Inc.

A structurally integrated biopsy system includes a movable base having wheels to facilitate movement of the structurally integrated biopsy system. On the movable based there is mounted a tissue removal system, an ultrasound imaging system, and a controller. The tissue removal system includes a probe connector configured to connect to a tissue removal probe. The ultrasound imaging system is configured to generate an ultrasound image of a body region of a patient, and has an image display system having an image display screen to display ultrasound images taken by the ultrasound imaging system. The controller is configured to be in communication with each of the tissue removal system and the ultrasound imaging system to both provide control information for the ultrasound imaging system and provide control information for the tissue removal system in the structurally integrated biopsy system. 120-. (canceled)21. A structurally integrated biopsy system , comprising:a movable base having wheels to facilitate movement of the structurally integrated biopsy system;a tissue removal system mounted to the movable base, the tissue removal system including a probe connector configured to connect to a tissue removal probe;an ultrasound imaging system directly connected to the tissue removal system, the ultrasound imaging system mounted to the movable base, the ultrasound imaging system being configured to generate an ultrasound image of a body region of a patient, and having an image display system having an image display screen to display ultrasound images taken by the ultrasound imaging system; anda controller mounted to the movable base, the controller configured to be in communication with each of the tissue removal system and the ultrasound imaging system to both provide control information for the ultrasound imaging system and provide control information for the tissue removal system in the structurally integrated biopsy system.2244-. (canceled)45. The structurally ...

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Номер записи: 127
14-02-2019 дата публикации

Biopsy device with fluid delivery to tissue specimens

Номер: US20190046167A1
Автор: Frank R. Louw, Jason H. Safabash, Martin V. Shabaz, Paul Lubock, Richard L. Quick
Принадлежит: SenoRx Inc

An apparatus for collecting one or more tissue specimens includes a tissue specimen collector having a cannula receiving opening, a vacuum opening, and an interior. The vacuum opening is on a first axis, and the cannula receiving opening is on a second axis. A removable tissue specimen retaining member is positioned within the interior of the tissue specimen collector. The removable tissue specimen retaining member has a plurality of openings that are interposed between the first axis of the vacuum opening and the second axis of the cannula receiving opening. The removable tissue specimen retaining member is movable along the second axis. An elongated tissue cutting member extends through the cannula receiving opening of the tissue specimen collector to position a proximal end of the elongated cutting member in the interior above the plurality of openings of the removable tissue specimen retaining member.

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Номер записи: 128
19-02-2015 дата публикации

FIBROUS MARKER AND INTRACORPOREAL DELIVERY THEREOF

Номер: US20150051477A1
Автор: Jones Michael L., Lubock Paul, Malchow Lloyd H.
Принадлежит:

An intracorporeal marker delivery system includes a delivery device including a delivery cannula and a plunger. The delivery cannula has an inner lumen, a distal tip, and a discharge opening in communication with the inner lumen. A radiographically detectable marker having a fibrous-body and a radiographically detectable marker element coupled to the fibrous body is disposed within and pushable by the plunger through the inner lumen of the delivery cannula. An MRI detectable distal tip plug is disposed at least in part within a distal portion of the inner lumen distal to the radiographically detectable marker, and configured to partially occlude the discharge opening in the delivery cannula. An ultrasound detectable short term marker is interposed between the radiographically detectable marker and the MRI detectable distal tip plug in the inner lumen of the delivery cannula. 116-. (canceled)17. An intracorporeal marker delivery system , comprising:a delivery device including a delivery cannula and a plunger, the delivery cannula having an inner lumen, a distal tip, and a discharge opening in communication with the inner lumen, and the plunger having a plunger shaft slidably received in the inner lumen;a radiographically detectable marker having a fibrous body and a radiographically detectable marker element coupled to the fibrous body, the radiographically detectable marker disposed within and pushable by the plunger through the inner lumen of the delivery cannula;an MRI detectable distal tip plug configured to expand in the presence of body fluids, the MRI detectable distal tip plug disposed at least in part within a distal portion of the inner lumen distal to the radiographically detectable marker, and configured to partially occlude the discharge opening in the delivery cannula; andan ultrasound detectable short term marker, the ultrasound detectable short term marker being interposed between the radiographically detectable marker and the MRI detectable distal ...

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Номер записи: 129
03-03-2016 дата публикации

METHODS AND APPARATUS FOR SECURING MEDICAL INSTRUMENTS TO DESIRED LOCATIONS IN A PATIENT'S BODY

Номер: US20160058433A1
Автор: Burbank Fred H., Jones Michael L., Lubock Paul, Quick Richard L.
Принадлежит:

A medical device includes a shaft having a distal end and a distal tip. An anchor mechanism is coupled to the distal end proximal to the distal tip. The anchor mechanism includes a rolled sheet of material and a sleeve located to surround the rolled sheet of material to maintain the rolled sheet of material in an initial rolled configuration, and is configured such that when the sleeve is retracted, the rolled sheet of material unrolls to expand radially to anchor the medical device. 148-. (canceled)49. A medical device , comprising:a shaft having a distal end and a distal tip;an anchor mechanism coupled to the distal end proximal to the distal tip, the anchor mechanism including a rolled sheet of material and a sleeve located to surround the rolled sheet of material to maintain the rolled sheet of material in an initial rolled configuration, and configured such that when the sleeve is retracted, the rolled sheet of material unrolls to expand radially to anchor the medical device.50. The medical device of claim 49 , wherein the rolled sheet of material is a rolled stent structure.51. The medical device of claim 49 , comprising a cutting element disposed on the distal end of the shaft claim 49 , the cutting element configured for cutting target tissue that surrounds the shaft.52. The medical device of claim 51 , wherein the cutting element is a radially expandable electrosurgical cutting element.53. The medical device of claim 49 , comprising a tip end cutting element disposed at the distal tip of the shaft claim 49 , the tip end cutting element configured to facilitate longitudinal entry into tissue.54. The medical device of claim 53 , further comprising a radially expandable cutting element.55. The medical device of claim 54 , wherein each of the tip end cutting element and the radially expandable cutting element is an electrosurgical cutting element.56. A method of operating a medical device claim 54 , comprising:providing a medical device having a shaft having a ...

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Номер записи: 130
07-03-2019 дата публикации

HEMOSTASIS VALVES AND METHODS OF USE

Номер: US20190070401A1
Автор: Lubock Paul, Merritt Benjamin E., Thress John C.
Принадлежит:

Devices, systems, and methods for sealing medical devices, particularly during intravascular access, are disclosed herein. Some aspects relate to a hemostatic valve for sealing a wide range of medical devices, such as catheters, wires, embolectomy systems. The valve can include an elongate member having a first end, a second end, and a central lumen extending therebetween. A reinforcement structure extends along at least a portion of the elongate member and is coupled to the elongate member. A shell defining a first aperture and a second aperture may be included, which first and second apertures can be fluidly coupled by the elongate member. A tensioning mechanism is coupled to the shell and to the elongate member, the tensioning mechanism can be moveable between a first configuration wherein the tensioning mechanism is collapsed and the central lumen is sealed and a second configuration wherein the central lumen is open. 1. A hemostatic valve for sealing a medical device , the hemostatic valve comprising:an elongate member having a first end, a second end, and a central lumen extending therebetween, wherein the elongate member is pliable;a reinforcement structure extending along at least a portion of the elongate member, wherein the reinforcement structure is coupled to the elongate member; andan active tensioning mechanism coupled to the elongate member, wherein the tensioning mechanism is moveable between a first configuration wherein the central lumen is constricted and sealed and a second configuration wherein the central lumen is open.2. The hemostatic valve of claim 1 , wherein the elongate member comprises a compliant polymer tube.3. The hemostatic valve of claim 1 , wherein the tensioning mechanism comprises at least one filament extending at least partially around the elongate member.4. The hemostatic valve of claim 3 , wherein the reinforcement structure is positioned between the at least one filament and the elongate member.5. The hemostatic valve of ...

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Номер записи: 131
19-03-2015 дата публикации

BIOPSY DEVICE WITH FLUID DELIVERY TO TISSUE SPECIMENS

Номер: US20150080760A1
Автор: Louw Frank R., Lubock Paul, Quick Richard L., Safabash Jason H., Shabaz Martin V.
Принадлежит:

A method of collecting one or more tissue specimens in a tissue biopsy system includes: providing a housing with a releasable proximal housing portion having an input port, a vacuum port, an interior, and a tissue specimen retaining member within the interior interposed between the input port and the vacuum port, the interior being in fluid communication with the inner lumen of an elongated tissue cutter, the tissue specimen retaining member having a plurality of openings configured to retain the one or more tissue specimens and to pass fluid and debris; inserting the proximal end of the elongated cutting member through the input port of the releasable proximal housing portion to position the proximal end in the interior above the plurality of openings of the tissue specimen retaining member; applying a vacuum to the vacuum port; and cutting a tissue specimen from a tissue site with the elongated tissue cutter. 118-. (canceled)19. A method of collecting one or more tissue specimens in a tissue biopsy system having a housing and an elongated tissue cutter coupled to the housing , the elongated tissue cutter having a proximal end , a distal end , a longitudinal extent , and an inner lumen extending between the proximal end and the distal end , comprising:providing the housing with a releasable proximal housing portion having an input port, a vacuum port, an interior, and a tissue specimen retaining member within the interior interposed between the input port and the vacuum port, the interior being in fluid communication with the inner lumen of the elongated tissue cutter, the tissue specimen retaining member within the interior having a plurality of openings configured to retain the one or more tissue specimens and to pass fluid;inserting the proximal end of the elongated tissue cutter through the input port of the releasable proximal housing portion to position the proximal end in the interior above the plurality of openings of the tissue specimen retaining member; ...

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Номер записи: 132
05-06-2014 дата публикации

UNIVERSAL MEDICAL DEVICE CONTROL CONSOLE

Номер: US20140155771A1
Автор: DABNEY James H., Kussman Daniel, Louw Frank R., Lubock Paul, Quick Richard L., Shabaz Martin V.
Принадлежит: SenoRx, Inc.

A control console is disclosed for controlling one or more medical devices. The control console communicates to at least one medical device, and at least one peripheral module associated with the medical device if needed. The control console has a microprocessor for processing data to direct an operation of the medical device. 1. A control console for controlling a variety of electrically powered medical devices , comprising:a device connecting module configured to communicate with each of a biopsy medical device and non-biopsy medical device; anda microprocessor based control module coupled to the device connecting module, the control module configured to direct an operation of the biopsy medical device based on communications from the biopsy medical device and configured to control one or more functions of the non-biopsy medical device based on communications from the non-biopsy medical device.252-. (canceled)53. The control console of claim 1 , wherein the non-biopsy medical device is one of a temperature probe claim 1 , a heart rate monitor device claim 1 , a drug infusion tool claim 1 , and an anesthesia tool.54. The control console of claim 1 , wherein the biopsy medical device includes at least one radio frequency or mechanically energized tool.55. The control console of claim 1 , further comprising at least one peripheral module associated with the biopsy medical device claim 1 , wherein the control module is communicatively interposed between the at least one peripheral module and the biopsy medical device.56. The control console of claim 55 , wherein the at least one peripheral module is controlled by the biopsy medical device.57. The control console of claim 55 , wherein the at least one peripheral module is a footswitch module.58. The control console of claim 55 , wherein the at least one peripheral module is a vacuum pump module.59. The control console of claim 55 , wherein the at least one peripheral module is a fluid pump module.60. The control ...

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Номер записи: 133
23-03-2017 дата публикации

TISSUE SPECIMEN ISOLATING AND DAMAGING DEVICE AND METHOD

Номер: US20170079626A1
Автор: Burbank Fred H., Lubock Paul
Принадлежит:

A device and method for treatment of a tissue specimen disposed in surrounding tissue has a tissue specimen isolating toot and a tissue specimen damager. The tissue specimen isolating tool isolates the tissue specimen from the surrounding tissue. The tissue specimen damager damages the tissue, with a possible end result being necrosis. The severing tool may have a cutting member that is extendable to an outwardly radially bowed position about device. The tissue specimen is isolated by rotating the cutting member about the tissue specimen. The cutting member may be functionally connected to a cutting member radio frequency generation source. The tissue specimen damager may damage the tissue specimen using ionizing radiation, cutting devices, thermal treatment devices, chemical treatment devices, or sealing an outer boundary of the tissue specimen. 118-. (canceled)19. A tissue collection apparatus for collecting a tissue specimen , comprising:a separating device configured to separate the tissue specimen from surrounding tissue;a plurality of tissue specimen damaging elements configured to engage and damage the separated tissue specimen, and configured for operation independent from the separating device; andan encapsulating device configured to encapsulate the separated and damaged tissue specimen, the encapsulating device configured for operation independent from the separating device and the plurality of tissue specimen damaging elements.20. The tissue collection apparatus of claim 19 , further comprising a radiofrequency generator coupled to the plurality of tissue specimen damaging elements.21. The tissue collection apparatus of claim 20 , comprising a wand to which the plurality of tissue specimen damaging elements is coupled claim 20 , each tissue specimen damaging element of the plurality of tissue specimen damaging elements being a wire having a free end claim 20 , the free end oriented to extend at an acute angle with respect to a longitudinal extent of the ...

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Номер записи: 134
23-03-2017 дата публикации

BRACHYTHERAPY DEVICE FOR FACILITATING ASYMMETRICAL IRRADIATION OF A BODY CAVITY

Номер: US20170080252A1
Автор: Jones Michael L., Louw Frank R., Lubock Paul
Принадлежит: Hologic, Inc.

The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity. 145.-. (canceled)46. A method comprising:inserting at least partially into a body cavity a device comprising a shaft and an inflatable member disposed about a portion of the shaft;inflating the inflatable member such that at least a portion of the inflatable member at least partially contacts tissue that defines the body cavity;expanding away from an axis of the shaft, spaced apart from but within the inflatable member, a radiation delivery tube; andinserting a radiation source into the radiation delivery tube.47. The method of claim 46 , wherein expanding the radiation delivery tube comprises not contacting an inner surface of the inflated inflatable member.48. The method of claim 46 , wherein the radiation tube is disposed in the shaft and wherein the shaft is deflectable away from the axis.49. The method of claim 48 , further comprising pulling a pull wire so as to expand the radiation delivery tube.50. The method of claim 46 , further comprising pushing the radiation delivery tube into the lumen so as to expand the radiation delivery tube.51. The method of claim 46 , wherein claim 46 , prior to expansion of the radiation delivery tube claim 46 , the radiation delivery tube is disposed in a compartmented support element that extends between a proximal end and a distal end of the balloon.52. The method of claim 51 , wherein the compartmented support element defines a compartment that extends longitudinally along the compartmented support element.53. A method comprising:inserting at ...

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Номер записи: 135
19-03-2020 дата публикации

TISSUE CUTTING MEMBER FOR A BIOPSY DEVICE

Номер: US20200085416A1
Автор: Louw Frank R., Lubock Paul, Quick Richard L.
Принадлежит:

A biopsy device includes a tissue cutting member slidably disposed within a probe component. The tissue cutting member has a distal tubular portion having a longitudinal axis and a flared distal section. The flared distal section has an inclined distal tip and an outwardly flared distal tubular portion that defines an inner tissue receiving aperture. The inclined distal tip has a beveled front face with a leading tissue cutting edge and a trailing cutting edge. A longitudinally oriented opening is in the flared distal section. The longitudinally oriented opening has an open distal end and is configured to extend from a closed proximal end to the open distal end. The closed proximal end has a relief opening with a transverse dimension larger than a transverse dimension of the longitudinally oriented opening adjacent the relief opening. The longitudinally oriented opening diverges to intersect the trailing cutting edge. 142-. (canceled)43. A biopsy device , comprising:a probe component having an inner lumen, a distal tip, and a tissue receiving aperture; and a distal tubular portion having a longitudinal axis and a flared distal section, the flared distal section having an inclined distal tip and an outwardly flared distal tubular portion that defines an inner tissue receiving aperture, the inclined distal tip having a beveled front face with a leading cutting edge and a trailing cutting edge, the outwardly flared distal tubular portion configured to outwardly flare in a distal direction toward the leading cutting edge; and', 'a longitudinally oriented opening in the flared distal section of the distal tubular portion, the longitudinally oriented opening having an open distal end and configured to extend from a closed proximal end to the open distal end, the closed proximal end having a relief opening with a transverse dimension larger than a transverse dimension of the longitudinally oriented opening adjacent the relief opening, the longitudinally oriented opening ...

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Номер записи: 136
20-04-2017 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20170105745A1
Автор: Cox Brian J., Lubock Paul, Rosenbluth Robert F.
Принадлежит:

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material. 1. A device for treating an embolism that at least partially restricts blood flow through a blood vessel , the device comprising:an elongated shaft having a proximal region and a distal region;an expandable braid attached to the distal region of the elongated shaft, the braid having a plurality of radially extending portions and at least one cylindrical portion, and the radially extending portions and the cylindrical portion being configured to move from a compressed state sized to fit in a delivery catheter to an expanded state;wherein the cylindrical portion is between a pair of the radially extending portions, and in the expanded state the cylindrical portion is configured to press radially outward against the embolism;wherein the radially extending portions extend radially outward from the cylindrical portion in the expanded state such that portions of the embolism are retained between the radially extending portions; andwherein the cylindrical portion has a first length along a longitudinal direction of the braid in the expanded state and the radially extending portions have a second length along the longitudinal direction of the braid in the expanded state that is less that the first length.2. The device of wherein at least a portion of the individual radially extending portions is disk-shaped.3. The device of wherein the individual radially extending portions include a curved portion and a linear portion.4. The device of wherein claim 1 , in the expanded state claim 1 , an exterior surface area of the device is at least two times ...

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Номер записи: 137
28-04-2016 дата публикации

Methods and apparatus for treating pulmonary embolism

Номер: US20160113666A1
Автор: Brian J. Cox, Paul Lubock, Richard Quick, Robert F. Rosenbluth
Принадлежит: Inceptus Medical LLC

A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member configured to extend through a delivery catheter and a plurality of clot engagement members positioned about the circumference of a distal portion of the support member. The individual clot engagement members can have a first portion and a second portion extending from the first portion, and the first portions can have a proximal region attached to the support member. In the deployed state, the individual second portions can extend from the distal region of one of the first portions and project radially outwardly relative to the support member in a curve that has a proximally extending section which defines a proximally facing concave portion.

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Номер записи: 138
12-05-2016 дата публикации

IMAGEABLE BIOPSY SITE MARKER

Номер: US20160128797A1
Автор: Burbank Fred H., Forcier Nancy, Jones Michael L., Lubock Paul
Принадлежит:

A biopsy site marker having at least one small marker body or pellet of bioresorbable material such as gelatin, collagen, polylactic acid, polyglycolic acid which has a radiopaque object, preferably with a non-biological configuration. The at least one bioresorbable body or pellet with a radiopaque object is deposited into the biopsy site, by a delivery device that includes an elongated tubular body with a piston slidable within the tubular body. One end of the tube is placed into the biopsy site. At least one but preferably several marker bodies or pellets are deposited sequentially into the biopsy site through the tube. At least the bioresorbable materials of the detectable markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise do not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction. 117-. (canceled)18. A device for marking a biopsy cavity site comprising: a proximal end;', 'a distal end;', 'a lumen disposed between the proximal end and the distal end; and', 'a piece disposed within the lumen,, 'an implantable medical device comprising'}wherein the piece comprises a component that is configured to generate and emit a first signal after receiving a second signal requesting that the component generate and emit the first signal when deployed at the biopsy cavity site thereby marking the biopsy cavity site.19. The device of wherein the component is adapted to emit a detectable first signal that comprises a radiofrequency signal or an ultrasound signal after the component receives the second signal.20. The device of wherein the second signal comprises an ultrasound signal.21. The device of wherein the component comprises a transmitter.22. The device of wherein the component comprises an ultrasound transducer.23. The device of wherein the second signal ...

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Номер записи: 139
14-05-2015 дата публикации

Expandable occlusion devices and methods of use

Номер: US20150133989A1
Автор: Brian J. Cox, Paul Lubock, Richard Quick, Robert Rosenbluth
Принадлежит: Inceptus Medical LLC

An occlusion device and method for occluding an undesirable vascular structure, such as a septal defect or left atrial appendage. The occlusion device includes a lattice structure that expands from a contracted catheter-deliverable state to an expanded state that occludes the vascular structure. The lattice structure has one or more braided layers, with structural braided layers that provide structural support to the device, and occlusive layers that provide a lattice braiding or pore sizes that promote further occlusion by a biological process, such as tissue ingrowth that further occludes the affected vascular structure.

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Номер записи: 140
21-05-2015 дата публикации

MARKER DELIVERY DEVICE WITH RELEASABLE PLUG

Номер: US20150141805A1
Автор: Jones Michael L., Lubock Paul, Merritt John
Принадлежит:

A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. A plunger is slidably disposed within the inner lumen of the elongated delivery cannula. The plunger has a distal end. At least one elongated fibrous marker body is pre-formed prior to being inserted into the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula at a location distal to the distal end of the plunger. The pre-formed at least one elongated fibrous marker body includes a fibrous material compressed and impregnated with a binding agent and freeze dried in the compressed condition. A releasable plug is disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body. 1. A marker delivery device for use in marking an intracorporeal tissue site , comprising:an elongated delivery cannula which has a distal end section, an inner lumen, and a discharge opening in the distal end section in communication with the inner lumen;a plunger slidably disposed within the inner lumen of the elongated delivery cannula, the plunger having a distal end;at least one elongated fibrous marker body pre-formed prior to being inserted into the inner lumen of the elongated delivery cannula, the at least one elongated fibrous marker body being slidably disposed within the inner lumen of the elongated delivery cannula at a location distal to the distal end of the plunger, the pre-formed at least one elongated fibrous marker body comprising a fibrous material compressed and impregnated with a binding agent and freeze dried in the compressed condition; anda releasable plug disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body.230-. (canceled)31. The marker delivery ...

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Номер записи: 141
09-05-2019 дата публикации

BIOPSY DEVICE WITH SELECTABLE TISSUE RECEIVING APERATURE ORIENTATION AND SITE ILLUMINATION

Номер: US20190133562A1
Автор: Louw Frank R., Lubock Paul, Quick Richard L., Safabash Jason H., Shabaz Martin V.
Принадлежит:

The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component with an elongated tubular section, a penetrating distal tip and a tissue receiving aperture in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The device also has a driver component to which the probe component is releasably secured. The driver has a drive member for adjusting the orientation of the tubular section and thus the aperture therein and one or more drive members for moving the tissue cutting member within the tubular section to sever a tissue specimen from tissue extending into the interior of the tubular section through the aperture. The motion imparted to the tissue cutter is at least longitudinal and preferably is also oscillation and/or rotational to effectively separate a tissue specimen from tissue extending through the aperture in the tubular section. 156-. (canceled)57. A biopsy device , comprising:a cannula having a proximal end and a longitudinal axis; anda specimen collector that contains the proximal end of the cannula, the specimen collector having a removable sample receiving cartridge that is removable along the longitudinal axis of the cannula to expose the proximal end of the cannula.58. The biopsy device of claim 57 , wherein the specimen collector has an interior claim 57 , and a portion of the removable sample receiving cartridge is removably positioned in the interior.59. The biopsy device of claim 58 , wherein the removable sample receiving cartridge has a proximal wall that is removably engaged with a proximal end of a body of the specimen collector.60. The biopsy device of claim 57 , wherein the cannula is an ...

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Номер записи: 142
09-05-2019 дата публикации

INTERLOCKING LOOP COUPLING/DECOUPLING SYSTEM FOR DEPLOYING VASCULAR IMPLANT DEVICES

Номер: US20190133600A1
Автор: Cox Brian J., Lubock Paul, Plaza Claudio, Quick Richard, Shabaz Martin
Принадлежит: Inceptus Medical LLC

In a system and method for deployment of an implant device, the implant device includes a first loop at its proximal end, and a deployment tool has a second loop attached at its distal end. A release wire slidably disposed within the deployment tool has a distal end extending through the first and second loops to releasably couple the implant device to the deployment tool, and a proximal portion extending from a proximal end of the deployment tool, which is held in a retraction device. The retraction device is operable to hold the proximal end of the deployment tool and to pull the release wire proximally through the deployment tool until the distal end of the release wire is withdrawn from the first and second loops to decouple the implant device from the deployment tool. 1. A system for deployment of a vascular implant device , comprising:a first loop attached to a proximal end of the implant device;a deployment tool having a proximal end and a distal end, with a second loop attached to the distal end of the deployment tool;a release wire slidably disposed within the deployment tool and having a proximal end and a distal end, the distal end of the release wire extending through the first and second loops to releasably couple the implant device to the deployment tool, the proximal end of the release wire extending proximally from the proximal end of the deployment tool; anda release wire retraction device operable to pull the release wire proximally through the deployment tool until the distal end of the release wire is withdrawn from the first and second loops to decouple the implant device from the deployment tool.2. The system of claim 1 , wherein the retraction device is configured to (a) hold the proximal end of the deployment tool claim 1 , (b) releasably grip the proximal end of the release wire claim 1 , and (c) pull the release wire proximally through the deployment tool.3. The system of claim 2 , wherein the release wire retraction device comprises:a ...

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Номер записи: 143
26-05-2016 дата публикации

Methods and apparatus for treating pulmonary embolism

Номер: US20160143721A1
Автор: Brian J. Cox, Paul Lubock, Richard Quick, Robert Rosenbluth
Принадлежит: Inceptus Medical LLC

A device and method for intravascular treatment of an embolism is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member configured to extend through a delivery catheter and a plurality of clot engagement members positioned about the circumference of a distal portion of the support member. The clot engagement members can be configured to penetrate clot material along an arcuate path and mechanically macerate clot and release embolic particles when re-sheathed into the delivery catheter.

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Номер записи: 144
24-05-2018 дата публикации

MARKER DELIVERY DEVICE WITH RELEASABLE PLUG

Номер: US20180140224A1
Автор: Jones Michael L., Lubock Paul, Merritt John
Принадлежит:

A tissue marker delivery device includes a hollow cannula and a fibrous marker. The hollow cannula has a distal region. The fibrous marker is disposed within the distal region. The fibrous marker includes a plurality of bioabsorbable strands, and a binding agent. Optionally, the tissue marker delivery device may include a short-term marker that includes an imagable agent that does not interfere with imaging adjacent tissue. 130-. (canceled)31. A tissue marker delivery device , comprising:a hollow cannula with a distal region; and a plurality of bioabsorbable strands, and', 'a binding agent., 'a fibrous marker disposed within the distal region comprising32. The device of claim 31 , wherein the fibrous marker has a 0.5-12 mm diameter.33. The device of claim 32 , wherein the fibrous marker has a 5-30 mm length.34. The device of claim 33 , wherein the binding agent comprises a water soluble component or the binding agent is water soluble.35. The device of claim 33 , wherein the binding agent is water soluble.36. The device of claim 35 , further comprising a short-term marker disposed in the hollow cannula claim 35 , the short-term marker comprises an imagable agent that does not interfere with imaging adjacent tissue.37. The device of claim 36 , wherein the imagable agent is imagable with ultrasound.38. The device of claim 37 , wherein the imagable agent is imagable with ultrasound for 2 weeks-1 year or 6 weeks-6 months after delivery.39. The device of claim 38 , wherein the imagable agent is radiopaque.40. The device of claim 39 , further comprising any one or any combination of titanium claim 39 , platinum claim 39 , gold claim 39 , iridium claim 39 , tantalum claim 39 , tungsten claim 39 , silver claim 39 , and rhodium.41. The device of claim 40 , wherein the imagable agent is imagable with MRI.42. The device of claim 33 , further comprising an imagable agent that does not interfere with imaging adjacent tissue.43. The device of claim 42 , wherein the imagable agent ...

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Номер записи: 145
11-06-2015 дата публикации

CAVITY-FILLING BIOPSY SITE MARKERS

Номер: US20150157418A1
Автор: Burbank Fred H., Jones Michael L., Lubock Paul
Принадлежит:

A method of marking a biopsy site within a patient's body includes providing a delivery tube having a plunger; carrying a quantity of an ultrasound-detectable bio-resorbable particulate material in the delivery tube distal to the plunger, the ultrasound-detectable bio-resorbable particulate material having a particle size between about 200 microns and about 500 microns and having internal bubble cavities having a size of at least 50 microns; and depressing the plunger for depositing the quantity of the ultrasound-detectable bio-resorbable particulate material at the biopsy site. 149-. (canceled)50. A method of marking a biopsy site within a patient's body , comprising:providing a delivery tube having a plunger;carrying a quantity of an ultrasound-detectable bio-resorbable particulate material in the delivery tube distal to the plunger, the ultrasound-detectable bio-resorbable particulate material having a particle size between about 200 microns and about 500 microns and having internal bubble cavities having a size of at least 50 microns; anddepressing the plunger for depositing the quantity of the ultrasound-detectable bio-resorbable particulate material at the biopsy site.5175-. (canceled)76. The method of claim 50 , wherein at least a portion of the ultrasound-detectable bio-resorbable particulate material has both internal bubble cavities and exposed surfaces of broken bubble cavities.77. The method of claim 50 , wherein the ultrasound-detectable bio-resorbable particulate material is an ultrasonically detectable powder that comprises about 65% by weight polylactic acid and about 35% by weight polyglycolic acid.78. The method of claim 50 , wherein the ultrasound-detectable bio-resorbable particulate material is a marker mass comprising an ultrasonically detectable powder detectable in-vivo within the biopsy site for a period of at least two weeks but not longer than six months claim 50 , the ultrasonically detectable powder having one or more bubble cavities ...

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Номер записи: 146
28-08-2014 дата публикации

POROUS BIOABSORBABLE IMPLANT

Номер: US20140239528A1
Автор: Govil Amit, Jones Michael L., Lubock Paul
Принадлежит: SenoRx, Inc.

In one form, the invention is directed to a method for forming a porous implant suitable for a cavity from which tissue has been removed, including mixing soluble alginate and a radiopaque imaging agent with water; incorporating a gas or a pore forming agent into the alginate-water mixture; transferring the alginate-water mixture with the gas or the pore forming agent into a mold to form the mixture into a solid body of desired shape; removing the water from the body; and converting at least part of the soluble alginate to a less soluble alginate. In another form, the invention includes forming a mixture by mixing about 0.5 percent to about 4 percent by weight chitosan into an acidified aqueous solution containing 1 percent to 25 percent by weight acetic acid, along with about 0.5 percent to about 5 percent by weight of a powdered radiopaque imaging agent. 116-. (canceled)17. A method for forming a porous implant suitable for a cavity from which tissue has been removed , comprising:a. mixing soluble alginate and a radiopaque imaging agent with water;b. incorporating a gas or a pore forming agent into the alginate-water mixture;c. transferring the alginate-water mixture with the gas or the pore forming agent into a mold to form the mixture into a solid body of desired shape;d. removing the water from the body; ande. converting at least part of the soluble alginate to a less soluble alginate.18. The method of claim 17 , comprising inserting an orientation marker into the body claim 17 , the orientation marker being spaced inwardly from exterior margins of the implant.19. The method of claim 17 , comprising inserting a plurality of radiopaque elements in an orientation lying in a plane.20. The method of wherein water is removed from the mixture by freeze drying or air drying.21. The method of wherein the soluble alginate is sodium alginate.22. The method of wherein the less soluble alginate is calcium alginate.23. The method of claim 17 , comprising sizing and shaping ...

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Номер записи: 147
23-05-2019 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20190150959A1
Автор: Cox Brian J., Lubock Paul, MARCHAND Philippe, Quick Richard, Rosenbluth Robert
Принадлежит:

A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member having a plurality of first clot engagement members and second clot engagement members positioned about the circumference of a distal portion of the support member. In an undeployed state, individual first clot engagement members can be linear and have a first length, and individual second clot engagement members can be linear and have a second length that is less than the first length. The clot engagement members can be configured to penetrate clot material along an arcuate path and hold clot material to the clot treatment device. 1. A system for intravascularly treating clot material in a blood vessel , comprising:a guide catheter having a lumen;an elongated tubular structure configured to extend through the guide catheter;a clot treatment device coupled to a distal portion of the elongated tubular structure, wherein the clot treatment device includes a mesh structure and a plurality of treatment portions, wherein the clot treatment device is radially expandable from (a) a low-profile state in which the clot treatment device is sized for delivery to the clot material through the lumen of the guide catheter to (b) a deployed state in which the clot treatment device is configured to engage the clot material; be fluidly coupled to the lumen of the guide catheter, and', 'when the clot treatment device is in the deployed state and engages the clot material, aspirate the lumen of the guide catheter during retraction of the clot treatment device into a distal portion of the guide catheter; and, 'a pump mechanism configured to—'}an expandable funnel member coupled to the distal portion of the guide catheter, wherein the funnel member is configured to inhibit the clot material from moving proximally through the blood vessel past ...

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Номер записи: 148
14-05-2020 дата публикации

INTERLOCKING LOOP COUPLING/DECOUPLING SYSTEM FOR DEPLOYING VASCULAR IMPLANT DEVICES

Номер: US20200146689A1
Автор: Cox Brian J., Lubock Paul, Plaza Claudio, Quick Richard, Shabaz Martin
Принадлежит: Inceptus Medical LLC

In a system and method for deployment of an implant device, the implant device includes a first loop at its proximal end, and a deployment tool has a second loop attached at its distal end. A release wire slidably disposed within the deployment tool has a distal end extending through the first and second loops to releasably couple the implant device to the deployment tool, and a proximal portion extending from a proximal end of the deployment tool, which is held in a retraction device. The retraction device is operable to hold the proximal end of the deployment tool and to pull the release wire proximally through the deployment tool until the distal end of the release wire is withdrawn from the first and second loops to decouple the implant device from the deployment tool. 1. A device for retracting a release wire having a distal end releasably coupling a vascular implant device to a distal end of an intravascularly-introduced deployment tool , wherein the deployment tool has a proximal portion from which a proximal portion of the release wire is exposed , the device comprising:a housing having an opening configured for receiving the proximal portion of the deployment tool from which the proximal portion of the release wire is exposed;a gripping assembly movably mounted in the housing for movement between a distal position and a proximal position, the gripping assembly comprising a fixed gripping element and a movable gripping element movable between a first position engaging the exposed proximal portion of the release wire against the fixed gripping element, and a second position disengaged from the exposed proximal portion of the release wire; anda guide assembly in the housing and comprising a lever pivotably mounted in the gripping assembly and having a first end in which the movable gripping element is mounted, and a second end movably seated in a guide path in the housing, wherein the guide path is configured to pivot the lever as the gripping assembly is ...

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Номер записи: 149
28-08-2014 дата публикации

Tissue site markers for in vivo imaging

Номер: US20140243675A1
Автор: Frank R. Louw, Fred H. Burbank, Michael L. Jones, Paul Lubock, Richard L. Quick, Stephen A. DeSantis
Принадлежит: SenoRx Inc

The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.

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Номер записи: 150
06-07-2017 дата публикации

DEVICE AND METHOD FOR TREATING VASCULAR OCCLUSION

Номер: US20170189041A1
Автор: Cox Brian J., Lubock Paul, Rosenbluth Robert F.
Принадлежит:

A system and method for managing an occlusion, such as a blood clot, within a lumen or passageway of a patient. More particularly, a system and method for rapidly restoring blood flow through an occlusion including a self-expanding, tubular member through which blood may flow when in an expanded state. The tubular member has a structure configured to engage the occlusive material, thereby allowing for extraction of at least a portion of the occlusive material. The system may further employ a material extraction member that is deployed distally of the tubular member. 1. An occlusion management system comprising:a catheter having an elongate shaft defining a first lumen;a pusher having a proximal end and a distal end, wherein the pusher is coaxial the first lumen;a self-expanding scaffold member formed of a tubular fenestrated structure with an open proximal end having a perimeter and an open distal end; anda capture member formed of a braided mesh and having a proximal end attached to the pusher, an everted distal portion, and a distal end attached to the perimeter of the proximal end of the scaffold member.2. The occlusion management system of claim 1 , wherein the capture member is self-expanding.3. The occlusion management system of claim 2 , wherein the distal end of the capture member is biased to evert in a relaxed state.4. The occlusion management system of claim 1 , wherein the scaffold member and the capture member form a continuous structure.5. The occlusion management system of claim 1 , wherein a diameter of the distal end of the capture member is no larger than a diameter of the proximal end of the scaffold member.6. The occlusion management system of claim 1 , further comprising a control feature controllably coupled to the distal end of the scaffold member through the first lumen of the catheter claim 1 , wherein the control feature is manipulable to control the formation of the everted distal portion of the scaffold member.7. The occlusion management ...

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Номер записи: 151
12-07-2018 дата публикации

DEVICES AND METHODS FOR TREATING VASCULAR OCCLUSION

Номер: US20180193043A1
Автор: Cox Brian J., Louw Jacob F., Lubock Paul, Marchand Phil, Merritt Benjamin E., Thress John C.
Принадлежит:

Systems and methods for removal of thrombus from a blood vessel in a body of a patient are disclosed herein. The method can include: providing a thrombus extraction device including a proximal self-expanding member formed of a fenestrated structure, a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure; advancing a catheter constraining the thrombus extraction device through a vascular thrombus, deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter; retracting the self-expanding member to unstack the portion of the net-like filament mesh structure and to capture the portion of the thrombus; and withdrawing the thrombus extraction device from the body. 1. A method for removal of thrombus from a blood vessel in a body of a patient , the method comprising;providing a thrombus extraction device comprising a proximal self-expanding member formed of a fenestrated structure, and a substantially cylindrical portion formed of a net-like filament mesh structure having a proximal end coupled to a distal end of the fenestrated structure;advancing a catheter constraining the thrombus extraction device through a vascular thrombus,deploying the thrombus extraction device by stacking a portion of the net-like filament mesh structure outside of the catheter by distally advancing the self-expanding member until the self-expanding member is beyond a distal end of the catheter;retracting the self-expanding member relative to the distal end of the net-like filament mesh structure to unstack the portion of the net-like filament mesh structure and to separate a portion of the thrombus from the vessel wall and to capture the portion of the thrombus within the net-like filament mesh structure; ...

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Номер записи: 152
09-10-2014 дата публикации

PERCUTANEOUSLY IMPLANTABLE ARTIFICIAL HEART VALVE SYSTEM AND ASSOCIATED METHODS AND DEVICES

Номер: US20140303719A1
Автор: Cox Brian J., Lubock Paul, Rosenbluth Robert
Принадлежит: Inceptus Medical, LLC

Expandable prosthetic valve devices for repair or replacement of a native valve in a heart of a patient and associated, systems and methods are disclosed herein. An expandable prosthetic valve device configured in accordance with a particular embodiment of the present technology can include a radially-expandable support having an expandable outer wall and a lumen defined by the outer wall. The device can also include a valve in the lumen and coupled to the support and a self-expanding retainer coupled to the outer wall. The retainer can have a structural braid configured to form a first annular flange on the outer wall of the support, and an occlusive braid configured to reduce blood flow through the retainer. 1. An expandable prosthetic valve device for implantation at a native valve region of a heart , the device comprising:a radially-expandable support having an expandable outer wall and a lumen defined by the outer wall;a valve in the lumen and coupled to the support; and a structural braid configured to form a first annular flange on the outer wall of the support when the device is in a deployed configuration; and', 'an occlusive braid configured to reduce blood flow through the braid., 'a self-expanding retainer coupled to the outer wall of the support, the retainer including-'}2. The device of claim 1 , wherein the structural braid is configured to form a second annular flange claim 1 , the second annular flange separated from the first annular flange by a gap claim 1 , and wherein the gap is configured to receive an annulus at the native valve region.3. The device of claim 2 , wherein the first and second annular flanges provide a compressive force against the annulus.4. The device of claim 1 , wherein the occlusive braid is a first occlusive braid and wherein the self-expanding braid includes a second occlusive braid.5. The device of claim 4 , wherein the structural braid is between the first and second occlusive braids.6. The device of claim 1 , wherein ...

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Номер записи: 153
20-08-2015 дата публикации

BIOPSY DEVICE WITH SELECTABLE TISSUE RECEIVING APERATURE ORIENTATION AND SITE ILLUMINATION

Номер: US20150230778A1
Автор: Louw Frank R., Lubock Paul, Quick Richard L., Safabash Jason H., Shabaz Martin V.
Принадлежит:

A method for collecting a tissue specimen from a target site within a patient includes rotating an elongated tubular section about a longitudinal axis to provide a desired aperture orientation of a tissue receiving aperture; applying a vacuum within the elongated tubular section to draw tissue at the tissue site through the tissue receiving aperture of the elongated tubular section into the interior thereof; advancing an elongated tissue cutting member longitudinally within the elongated tubular section to cut a tissue specimen from the tissue extending into the elongated tubular section; and applying a vacuum to the proximal end of the elongated tissue cutting member for transporting a cut tissue specimen through the inner lumen of the elongated tissue cutting member to discharge the cut tissue specimen directly from the proximal end of the elongated tissue cutting member into a tissue collection device. 136-. (canceled)37. A method for collecting one or more tissue specimens from a target site within a patient , comprising: [ an elongated tubular section which has a longitudinal axis, which has an inner lumen extending therein, which has a penetrating distal tip and which has a tissue receiving aperture proximal to the penetrating distal tip configured to receive tissue from the target site,', 'a first driven gear coupled to the elongated tubular section and configured to rotate, to in turn rotate the elongated tubular section around the longitudinal axis,', 'an elongated tissue cutting member which is disposed within the elongated tubular section, which has a distal end having at least one tissue cutting edge and which has an inner lumen extending therein, the elongated tissue cutting member having a proximal end opposite the distal end, and', 'a second driven gear coupled to the elongated tissue cutting member and configured to rotate to longitudinally move the elongated tissue cutting member relative to the elongated tubular section along the longitudinal axis ...

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Номер записи: 154
27-08-2015 дата публикации

DEVICE AND METHOD FOR TREATING VASCULAR OCCLUSION

Номер: US20150238207A1
Автор: Cox Brian J., Lubock Paul, Rosenbluth Robert F.
Принадлежит:

A system and method for managing an occlusion, such as a blood clot, within a lumen or passageway of a patient. More particularly, a system and method for rapidly restoring blood flow through an occlusion including a self-expanding, tubular member through which blood may flow when in an expanded state. The tubular member has a structure configured to engage the occlusive material, thereby allowing for extraction of at least a portion of the occlusive material. The system may further employ a material extraction member that is deployed distally of the tubular member. 1. An occlusion management system comprising:a catheter;a pusher; anda tubular member reversibly restrained in a compressed state within a lumen of the catheter and radially expanded from the compressed state upon retraction of the catheter relative to the pusher.2. The system of wherein a distal end of the pusher is attached to a proximal portion of the tubular member.3. The system of wherein a diameter of the member is largest at a distal portion of the tubular member.4. The system of wherein a distal portion of the tubular member is flared in a radially expanded state.5. The system of wherein a distal portion of the tubular member is bulbous in a radially expanded state.6. The system of further comprising an extraction member attached to a distal portion of the member.7. The system of wherein a distal portion of the tubular member is everted toward a proximal portion of the member.8. The system of further comprising a sheath having a lumen through which the catheter is advanced.9. The system of further comprising a sheath having a lumen through which a proximal tubular member is advanced.10. The system of wherein the catheter comprises an annular balloon near a distal end of the catheter.11. An occlusion management system comprising:a catheter;a pusher;a tubular member attached to a distal end of the pusher; andan extraction member extending distally of a distal end of the cylindrical member having a ...

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Номер записи: 155
30-10-2014 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20140324091A1
Автор: Cox Brian J., Lubock Paul, Rosenbluth Robert F.
Принадлежит: Inceptus Medical, LLC

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material. 1. A device for treating a pulmonary embolism that at least partially restricts blood flow through a pulmonary vessel , the device comprising:an elongated shaft having a proximal region and a distal region;an expandable braid attached to the distal region of the elongated shaft, the braid having a plurality of radially extending portions and at least one cylindrical portion, and the radially extending portions and the cylindrical portion being configured to move from a compressed state sized to fit in a delivery catheter to an expanded state;wherein the cylindrical portion is between a pair of the radially extending portions, and in the expanded state the cylindrical portion is configured to press radially outward against the pulmonary embolism;wherein the radially extending portions extend radially outward from the cylindrical portion in the expanded state such that portions of the pulmonary embolism are retained between the radially extending portions; andwherein the cylindrical portion has a first length along a longitudinal direction of the braid in the expanded state and the radially extending portions have a second length along the longitudinal direction of the braid in the expanded state that is less that the first length.2. The device of wherein at least a portion of the individual radially extending portions is disk-shaped.3. The device of wherein the individual radially extending portions include a curved portion and a linear portion.4. The device of wherein claim 1 , in the expanded state claim 1 , an exterior surface area of ...

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Номер записи: 156
06-11-2014 дата публикации

Graphical user interface for tissue biopsy system

Номер: US20140330113A1
Автор: Derek J. Daw, Frank R. Louw, Martin V. Shabaz, Paul Lubock, Richard L. Quick
Принадлежит: SenoRx Inc

A graphical user interface is disclosed for a tissue biopsy system having a tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient. The graphical user interface includes a first GUI area representing a first region of the target site from which the tissue cutting member has separated one or more tissue specimens. The graphical user interface further includes a second GUI area, visually distinguishable from the first GUI area, representing a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site.

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Номер записи: 157
30-08-2018 дата публикации

VASCULAR OCCLUSION DEVICES AND METHODS

Номер: US20180242980A1
Автор: Cox Brian J., Lubock Paul, Quick Richard, Rosenbluth Robert
Принадлежит: Inceptus Medical LLC

A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle. 1. A device for occluding a bodily lumen , comprising:a mesh structure comprising a plurality of braided filaments, the mesh structure defining a longitudinal axis extending between a proximal end and a distal end, the filaments of the mesh structure being fixed in a proximal hub at the proximal end and in a distal hub at the distal end;wherein the mesh structure is radially compressible from a fully-expanded relaxed configuration to a compressed configuration, and is resiliently expandable from the compressed configuration to a partially-expanded, constrained configuration when deployed in the lumen;wherein the mesh structure in the relaxed configuration includes a plurality of radially extending occlusion regions spaced along the longitudinal axis, each of the occlusion regions having a side defining an angle of 70° to 85° relative to the longitudinal axis of the structure; andwherein, in the constrained configuration of the mesh structure, each radially extending occlusion region defines two radial traverses of the lumen for each ...

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Номер записи: 158
15-09-2016 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20160262790A1
Автор: Cox Brian J., Lubock Paul, Rosenbluth Robert F.
Принадлежит:

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material. 130-. (canceled)31. A method of treating an embolism comprising:delivering an embolectomy device through the vasculature to an embolism that at least partially restricts blood flow through a vessel, wherein the embolectomy device comprises an expandable cylindrical section and at least first and second radial expansion members configured to expand outwardly from the cylindrical section, wherein the cylindrical section is between the first and second radial expansion members;deploying the embolectomy device within the embolism so as to restore blood flow through the embolism,wherein deploying the embolectomy device comprises expanding the cylindrical section within the embolism such that the cylindrical section forms an expanded flow channel through the embolism and expanding the radial expansion member to a greater extent than the cylindrical section, and wherein at full expansion of the cylindrical member the radial expansion member projects outward from the cylindrical member, and wherein the cylindrical section has a first length in a longitudinal direction and each of the first and second radial expansion members have a length in the longitudinal direction that is less than the first length of the cylindrical section at full expansion;moving the embolectomy device and at least a portion of the embolism along the vessel; andwithdrawing the embolectomy device and at least a portion of the embolism from the vessel.32. A method according to wherein deploying the embolectomy device comprises expanding a plurality of radial extensions of ...

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Номер записи: 159
20-08-2020 дата публикации

VASCULAR OCCLUSION DEVICES AND METHODS

Номер: US20200261098A1
Автор: Cox Brian J., Lubock Paul, Quick Richard, Rosenbluth Robert
Принадлежит:

A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle. 1. An implantable device for embolizing a blood vessel having an endoluminal wall defining a vascular lumen , the implantable device comprising:a mesh structure configured to radially expand from (a) a compressed delivery state to (b) an expanded deployed state when the implantable device is positioned at a target site in the vascular lumen of the blood vessel;wherein, in the delivery state, the mesh structure has a generally cylindrical shape; and the mesh structure includes a plurality of radially extending regions,', 'the radially extending regions are porous and configured to disrupt blood flow through the implantable device and the vascular lumen,', 'individual ones of the radially extending regions include an apex configured to contact the endoluminal wall of the blood vessel,', 'each of the apices has a thickness along a longitudinal axis of the occlusion device, and', 'the combined thicknesses of the apices is less than about 50% of a total length of the mesh structure along the longitudinal axis., 'wherein, in the expanded state—'} ...

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Номер записи: 160
29-10-2015 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20150305756A1
Автор: Cox Brian J., Lubock Paul, Quick Richard, Rosenbluth Robert F.
Принадлежит:

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material. 1. A device for treating a pulmonary embolism , comprising:an expandable flow restoration portion; anda plurality of capture elements including at least a first capture element and a second capture element, wherein the flow restoration portion is between the first and second capture elements, and wherein the flow restoration portion and the capture elements are configured to move from a low-profile undeployed state sized to fit within a delivery catheter to a deployed state in which the flow restoration portion has a first cross-sectional dimension greater than that of the low-profile state such that the flow restoration portion forms a flow channel through the device and the capture elements project outwardly from the flow restoration portion.2. The device of wherein the flow restoration portion and the capture elements comprise an expandable braided material that is heat set to have the deployed state.3. The device of any of and wherein the flow restoration portion and the capture elements are integrally formed from a common braided material.43. The device of any of - claims 1 , further comprising a plurality of flow restoration portions and the capture elements comprise a series of radially extending capture portions claims 1 , and wherein the radially extending capture portions are separated from each other by individual flow restoration portions.5. The device of wherein the flow restoration portions comprise expandable cylindrical sections and the capture elements comprise radially expandable disk-like capture portions of the ...

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Номер записи: 161
18-10-2018 дата публикации

METHODS AND APPARATUS FOR TREATING EMBOLISM

Номер: US20180296240A1
Автор: Cox Brian J., Lubock Paul, Quick Richard, Rosenbluth Robert F.
Принадлежит:

A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material. 1. A system for treating a pulmonary embolism , comprising: an expandable flow restoration portion; and', 'a plurality of capture elements including at least a first capture element and a second capture element, wherein the flow restoration portion is positioned between the first and second capture elements, and wherein the flow restoration portion and the capture elements are configured to move from a low-profile undeployed state sized to fit within a delivery catheter to a deployed state in which the flow restoration portion has a cross-sectional dimension greater than that of the undeployed state and the capture elements project outwardly from the flow restoration portion;, 'a clot treatment device including—'}a guide catheter having a shaft with a distal end portion, wherein the shaft includes a lumen configured to receive the clot treatment device in the undeployed state; andan expandable guide member at the distal end portion of the shaft, wherein the expandable guide member is configured to guide clot material into the guide catheter as the clot treatment device is withdrawn into the guide catheter.2. The system of wherein at least a portion of the expandable guide member is permeable to allow blood to flow through the expandable guide member.3. The system of wherein the expandable guide member comprises at least one of a self-expanding mesh structure or a self-expanding braided structure.4. The system of wherein the expandable guide member is formed from a tubular braid of elastic or super-elastic filaments that have been heat ...

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Номер записи: 162
10-10-2019 дата публикации

VASCULAR OCCLUSION DEVICES AND METHODS

Номер: US20190307464A1
Автор: Cox Brian J., Lubock Paul, Quick Richard, Rosenbluth Robert
Принадлежит:

A vascular occlusion device includes a braided filament mesh structure defining a longitudinal axis. The mesh structure has a relaxed configuration in which it has an axial array of radially-extending occlusion regions, each of which has a proximal side and a distal side meeting at a peripheral edge, the sides of each occlusion region forming a first angle relative to the longitudinal axis. Each occlusion region is axially separated from the adjacent occlusion region by a reduced-diameter connecting region. The mesh structure is radially compressible to a compressed state in which it is deployed intravascularly to a target site through a catheter. Upon deployment, the device radially expands to a constrained configuration in which the peripheral edges of the occlusion regions engage the vascular wall, and the sides of the occlusion regions form a second angle relative to the longitudinal axis that is smaller than the first angle. 1. An implantable device for embolizing a blood vessel having an endoluminal wall defining a vascular lumen , the implantable device comprising:a mesh structure configured to radially expand from (a) a compressed delivery state to (b) an expanded deployed state when the implantable device is positioned at a target site in the vascular lumen of the blood vessel;wherein, in the delivery state, the mesh structure has a generally cylindrical shape;and the mesh structure includes a plurality of radially extending regions,', 'the radially extending regions are porous and configured to disrupt blood flow through the implantable device and the vascular lumen,', 'individual ones of the radially extending regions include an apex configured to engage the endoluminal wall of the blood vessel,', 'each of the apices has a thickness along a longitudinal axis of the occlusion device, and', 'the combined thicknesses of the apices is less than about 50% of a total length of the mesh structure along the longitudinal axis., 'wherein, in the expanded state'}2. ...

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Номер записи: 163
17-12-2015 дата публикации

Tissue Cutting Member For A Biopsy Device

Номер: US20150359524A1
Автор: Louw Frank R., Lubock Paul, Quick Richard L.
Принадлежит:

A tissue cutting member includes a distal tubular portion having a side wall defining a lumen, a longitudinal axis, and a flared distal section. The flared distal section has an inclined distal tip and an outwardly flared distal tubular portion that defines an inner tissue receiving aperture. The inclined distal tip has a beveled front face with a leading tissue cutting edge and a trailing cutting edge. A single longitudinally oriented opening is in the side wall in the flared distal section which radially opens to the lumen. The longitudinally oriented opening has an open distal end and is configured to extend from a closed proximal end to the open distal end. The closed proximal end has a relief opening with a transverse dimension larger than a transverse dimension of the longitudinally oriented opening adjacent the relief opening. The longitudinally oriented opening diverges to intersect the trailing cutting edge. 142-. (canceled)43. A tissue cutting member for separating a tissue specimen from a target site within a patient's body comprising:a distal tubular portion including a side wall defining a lumen, a longitudinal axis, and a flared distal section, the flared distal section having an inclined distal tip at a distal end of the side wall and an outwardly flared distal tubular portion that defines an inner tissue receiving aperture, the inclined distal tip having a beveled front face with a leading cutting edge and a trailing cutting edge, the outwardly flared distal tubular portion being outwardly flared in a distal direction to the leading cutting edge; anda single longitudinally oriented opening in the side wall in the flared distal section which radially opens to the lumen, the single longitudinally oriented opening having an open distal end and configured to extend from a closed proximal end to the open distal end, the closed proximal end having a relief opening with a transverse dimension larger than a transverse dimension of the single longitudinally ...

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Номер записи: 164
06-12-2018 дата публикации

DEVICE AND METHOD FOR TREATING VASCULAR OCCLUSION

Номер: US20180344339A1
Автор: Cox Brian J., Lubock Paul, Rosenbluth Robert F.
Принадлежит:

A system and method for managing an occlusion, such as a blood clot, within a lumen or passageway of a patient. More particularly, a system and method for rapidly restoring blood flow through an occlusion including a self-expanding, tubular member through which blood may flow when in an expanded state. The tubular member has a structure configured to engage the occlusive material, thereby allowing for extraction of at least a portion of the occlusive material. The system may further employ a material extraction member that is deployed distally of the tubular member. 1. An occlusion management system comprising:a catheter having an elongate shaft defining a first lumen;a pusher having a proximal end and a distal end, wherein the pusher is coaxial the first lumen;a self-expanding scaffold member formed of a tubular fenestrated structure with an open proximal end having a perimeter and an open distal end; anda capture member formed of a braided mesh and having a proximal end attached to the pusher, an everted distal portion, and a distal end attached to the perimeter of the proximal end of the scaffold member.2. The occlusion management system of claim 1 , wherein the capture member is self-expanding.3. The occlusion management system of claim 2 , wherein the distal end of the capture member is biased to evert in a relaxed state.4. The occlusion management system of claim 1 , wherein the scaffold member and the capture member form a continuous structure.5. The occlusion management system of claim 1 , wherein a diameter of the distal end of the capture member is no larger than a diameter of the proximal end of the scaffold member.6. The occlusion management system of claim 1 , further comprising a control feature controllably coupled to the distal end of the scaffold member through the first lumen of the catheter claim 1 , wherein the control feature is manipulable to control the formation of the everted distal portion of the scaffold member.7. The occlusion management ...

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Номер записи: 165
06-12-2018 дата публикации

TISSUE SITE MARKERS FOR IN VIVO IMAGING

Номер: US20180344425A1
Автор: Burbank Fred H., DeSantis Stephen A., Jones Michael L., Louw Frank R., Lubock Paul, Quick Richard L.
Принадлежит:

A tissue marker delivery device includes an elongated marker insertion tube having a closed distal end. The closed distal end has a plurality of connected slits that form a plurality of openable petals. A piston is slidably disposed within the elongated marker insertion tube. At least one tissue marker is slidably disposed within the elongated marker insertion tube at a location distal to the piston and proximal to the closed distal end of the elongated marker insertion tube. 141-. (canceled)42. A tissue marker delivery device , comprising:an elongated marker insertion tube having a closed distal end, the closed distal end having a plurality of connected slits that form a plurality of openable petals;a piston slidably disposed within the elongated marker insertion tube; andat least one tissue marker slidably disposed within the elongated marker insertion tube at a location distal to the piston and proximal to the closed distal end of the elongated marker insertion tube.43. The tissue marker delivery device of claim 42 , wherein the plurality of connected slits form an X-arrangement of slits.44. The tissue marker delivery device of claim 42 , wherein the plurality of openable petals consists of four petals.45. The tissue marker delivery device of claim 42 , wherein the at least one tissue marker is a plurality of tissue markers slidably disposed within the elongated marker insertion tube claim 42 , each tissue marker of the plurality of tissue markers having a region configured to reflect ultrasound during ultrasound imaging.46. The tissue marker delivery device of claim 42 , wherein the at least one tissue marker includes a radiopaque element having an artificial shape which is the lower-case Greek letter Gamma.47. The tissue marker delivery device of claim 42 , wherein the at least one tissue marker includes a radiopaque element having an artificial shape which is a coil.48. The tissue marker delivery device of claim 42 , wherein the at least one tissue marker ...

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Номер записи: 166
21-12-2017 дата публикации

TISSUE CUTTING MEMBER FOR A BIOPSY DEVICE

Номер: US20170360417A1
Автор: Louw Frank R., Lubock Paul, Quick Richard L.
Принадлежит:

The invention is directed to tissue cutting members and biopsy devices with such tissue cutting member for separating a tissue specimen from a patient's body at a target site. The tissue cutting member is slidably disposed within an inner lumen of an elongated probe member of the biopsy device to cut a tissue specimen drawn into the interior of an outer cannula of the biopsy device through a tissue receiving aperture in the probe. The tissue cutting member has a tubular distal portion with a distal tip having an outer tissue cutting edge, an inner tissue receiving aperture, and a longitudinally oriented opening with a closed proximal end and open distal end which opens to the inner tissue receiving aperture to facilitate flaring of the distal tubular portion. The cutting member has at least one opening in a wall of the tubular portion to maintain a vacuum during use. 142-. (canceled)43. A method for forming a tissue cutting member to separate a tissue specimen from a target site within a patient's body , comprising:providing a distal tubular portion including a side wall defining a lumen, a longitudinal axis, and a flared distal section;configuring the flared distal section to include an inclined distal tip at a distal end of the side wall and an outwardly flared distal tubular portion that defines an inner tissue receiving aperture, the inclined distal tip having a beveled front face with a leading cutting edge and a trailing cutting edge, the outwardly flared distal tubular portion being outwardly flared in a distal direction to the leading cutting edge;providing a single longitudinally oriented opening in the side wall in the flared distal section which radially opens to the lumen, the single longitudinally oriented opening having an open distal end and extending from a closed proximal end to the open distal end; andproviding a relief opening at the closed proximal end, the relief opening having a transverse dimension larger than a transverse dimension of the ...

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Номер записи: 167
23-06-2020 дата публикации

Graphical user interface for tissue biopsy system

Номер: US10687733B2
Автор: Derek J. Daw, Frank R. Louw, Martin V. Shabaz, Paul Lubock, Richard L. Quick
Принадлежит: SenoRx Inc

A screen providing a graphical user interface (GUI) for a tissue biopsy system includes a circular area and a plurality of GUI areas of variable size located in the circular area. The plurality of GUI areas includes a first GUI area, a second GUI area, and a third GUI area. The first GUI area is configured to represent a first region of the target site from which at least one tissue specimen has been separated from tissue at the target site by a tissue cutting member. The second GUI area is configured to represent a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site. The third GUI area is configured to represent a third region in which the tissue cutting member is deployed to separate a tissue specimen from tissue at the target site.

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Номер записи: 168
05-08-2014 дата публикации

Graphical user interface for tissue biopsy system

Номер: US8795195B2
Автор: Derek Daw, Frank R. Louw, Martin V. Shabaz, Paul Lubock, Richard L. Quick
Принадлежит: SenoRx Inc

A graphical user interface is disclosed for a tissue biopsy system having a tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient. The graphical user interface includes a first GUI area representing a first region of the target site from which the tissue cutting member has separated one or more tissue specimens. The graphical user interface further includes a second GUI area, visually distinguishable from the first GUI area, representing a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site.

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Номер записи: 169
16-09-2003 дата публикации

High frequency power source

Номер: US6620157B1
Автор: Conrad Sawicz, Dan Kussman, James Huntington Dabney, Paul Lubock, Richard L. Quick
Принадлежит: SenoRx Inc

A high frequency electrosurgical power generator configured to produce electrical power at a frequency of about 1 to about 14 MHz and preferably having an essentially sinusoidal waveform with a voltage level up to 1,000 Vrms, and a current level up to 5 Amps. The output of the high frequency electrosurgical power generator is connected to an electrosurgical tool configured to receive the voltage and current produced by the electrosurgical power generator and deliver the voltage and current to an electrosurgical site. The output of the electrosurgical generator preferably is an essentially sinusoid waveform with a frequency between about 3 MHz and about 8 MHz, up to about 700 volts rms, up to about 2 amps, with a total power of up to 1,000 watts.

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Номер записи: 170
15-05-2012 дата публикации

Plugged tip delivery tube for marker placement

Номер: US8177792B2
Автор: Jason H. Safabash, John Merritt, Martin Shabaz, Paul Lubock
Принадлежит: SenoRx Inc

An intracorporeal marker delivery device includes a delivery tube which has a tapered, tissue penetrating distal tip, an inclined discharge orifice in the tapered distal tip and an inner bore extending to the orifice. A plurality of remotely detectable markers, which are formed at least in part of bioresorbable material, are slidably disposed within the inner bore. A plug having an inclined exposed surface, which is formed at least in part of bioresorbable material, is releasably secured within the inner bore of the delivery tube distal to the plurality of remotely detectable markers disposed therein to retain the plurality of remotely detectable markers within the inner bore. The plug is disposed at least in part within the inclined discharge orifice. A plunger is slidably disposed within the inner bore proximal to the plurality of remotely detectable markers.

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Номер записи: 171
10-07-2012 дата публикации

Cavity-filling biopsy site markers

Номер: US8219182B2
Автор: Fred H. Burbank, Michael L. Jones, Paul Lubock
Принадлежит: SenoRx Inc

An ultrasound-detectable biopsy marker mass has a detectable in-vivo lifetime during which the marker mass remains readily detectable by ultrasound imaging. The ultrasound-detectable biopsy marker mass is formed of particles of a bio-resorbable material having bubble cavities and having a particle size between about 200 microns and about 500 microns.

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Номер записи: 172
17-07-2012 дата публикации

Tissue site markers for in vivo imaging

Номер: US8224424B2
Автор: Frank Louw, Fred H. Burbank, Michael L. Jones, Paul Lubock, Richard L. Quick, Stephen A. De Santis
Принадлежит: SenoRx Inc

The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.

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Номер записи: 173
07-01-2014 дата публикации

Fibrous marker and intracorporeal delivery thereof

Номер: US8626269B2
Автор: Lloyd H. Malchow, Michael L. Jones, Paul Lubock
Принадлежит: SenoRx Inc

An intracorporeal marker includes a fibrous unitary marker body having bioabsorbable fibers compressed into a compressed configuration, and bound in the compressed configuration by a polymer binding agent. The intracorporeal marker may be incorporated into an intracorporeal marker delivery device having a delivery cannula which has a distal tip, an inner lumen and a discharge opening in communication with the inner lumen. The compression and binding occur prior to insertion of the fibrous unitary marker body into the inner lumen of the delivery cannula. The fibrous unitary marker body is slidably disposed within and pushable through the inner lumen of the elongated delivery cannula proximal to the discharge opening.

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Номер записи: 174