11-10-2018 дата публикации
Номер: US20180290976A1
Принадлежит:
Provided are novel compounds of Formula (I): 2. The compound of claim 1 , wherein Ris hydrogen.3. The compound of claim 1 , wherein{'sup': 1', 'X, 'Ris selected from carbocyclyl, heterocyclyl, aryl and heteroaryl, each of which being optionally substituted with up to 3 substituents independently selected from R;'}{'sup': 2', '3, 'sub': 1', '4, 'each of Rand Ris independently selected from hydrogen, halo, and C-Calkyl;'}{'sup': '5', 'sub': 1', '4, 'each Ris independently selected from hydrogen and C-Calkyl;'}{'sup': '6', 'Ris hydrogen;'}{'sup': 8', 'Y, 'sub': 0', '4', '0', '4', '0', '4', '0', '4, 'Ris selected from —(C-Calkylene)-carbocyclyl, —(C-Calkylene)-heterocyclyl, —(C-Calkylene)-aryl, and —(C-Calkylene)-heteroaryl, wherein said carbocyclyl, heterocyclyl, aryl, and heteroaryl are each optionally substituted with up to 3 substituents independently selected from R;'}{'sup': X', 'Y', 'c', 'a', 'b', 'c', 'd', 'c', 'e', 'f', 'c', 'c', 'c', 'c', 'c', 'c', 'e', 'f', 'd', 'c', 'e', 'f', 'd', 'c', 'd', 'c', 'e', 'f', 'd', 'c', 'e', 'f', 'd', 'e', 'f', 'd', 'e', 'f', 'c', 'c', 'c', 'd', 'c', 'g', 'h', 'c', 'c', 'e', 'f', 'c', 'X', 'Y, 'sub': i', '2', '2', '1', '6', '2', '1-4', '2', '1-4', '2', '1-4', '2', '1-4', '1', '6', '2', '1-4', '2', '1-4', '2', '1-4', '2', '1-4', '2', 'i', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3', '1', '3, 'Rand Rare each independently selected from halogen, —CN, —OR, —NRR, —S(O)R, —NRS(O)R, —S(O)NRR, —C(═O)OR, —OC(═O)OR,—OC(═O)R, —OC(═S)OR, —C(═S)OR, —O(C═S)R, —C(═O)NRR, —NRC(═O)OR, —C(═S)NRR, —NRC(═S)R, —NR(C═O)OR, —O(C═O)NRR, —NR(C═S)OR, —O(C═S)NRR, —NR(C═O)NRR, —NR(C═S)NRR, —C(═S)R, —C(═O)OR, (C-C)alkyl, cycloalkyl, —(CH)-cycloalkyl, heterocyclyl, —(CH)-heterocyclyl, aryl, —(CH)-aryl, heteroaryl and —(CH)-heteroaryl, wherein each of the (C-C)alkyl, cycloalkyl, —(CH)-cycloalkyl, heterocyclyl, —(CH)-heterocyclyl, aryl, —(CH)-aryl, heteroaryl and —(CH)-heteroaryl are optionally substituted with halogen, OR, —NO, —CN, —NRC(═O)OR, —NRR, —S(O ...
Подробнее
