31-01-1995 дата публикации
Номер: US5385719A
Novel compounds having use as contrast agents in magnetic resonance imaging, as well as other uses, are described. The compounds are comprised of a copolymer which comprises at least two of a first monomer of the formula X 1 --(CHR 2 CHR 2 --Y) n --(CHR 2 ) m --CHR 2 CHR 2 --X 2 , wherein X 1 and X 2 are, independently, OH, NH 2 , NHR 1 , COOH, COOR 1 , SH, or Z, Y is O, NH, NR 1 , S, or CO, n is 0-10,000, m is 0 or 1, each Z is, independently, Cl, Br, or I, each R 1 is, independently, a C 1 -C 20 substituted alkyl or cycloalkyl, and each R 2 is, independently, H or OH, and at least one of a second monomer which is a polynitrilo chelating agent having at least two COOH, COOR 1 , or COZ groups, the first and second monomers being bound to one another to form a copolymer through an ester, amide, or carboxylic thioester linkage of at least one of the OH, NH 2 , NHR 1 , COOH, COOR 1 , SH or Z groups of the first monomer, and at least one of the COOH, COOR 1 , or COZ groups of the second monomer. Optionally, the copolymer may also include at least one of a third monomer which is a targeting agent or a targeting agent ligand having an OH, NH 2 , NHR 1 , COOH, COOR 1 , SH, or COZ group, wherein R 1 is described as above, and wherein the third monomer is also bound with the first and second monomers to form a copolymer through an ester, amide, or carboxylic thioester linkage. For magnetic resonance imaging, for example, the copolymer may further comprise a paramagnetic ion chelated to the chelating agent.
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