18-12-2014 дата публикации
Номер: US20140371201A1
Автор:
BOEZIO Alessandro,
BOEZIO Christiane,
BUTLER John R.,
CHU-MOYER Margaret Yuhua,
DIMAURO Erin F.,
DINEEN Thomas,
GRACEFFA Russell,
Guzman-Perez Angel,
HUANG Hongbing,
KREIMAN Charles,
LA Daniel,
MARX Isaac E.,
MILGRIM Benjamin Charles,
NGUYEN Hanh Nho,
PETERSON Emily,
Romero Karina,
SPARLING Brian,
WEISS Matthew
Принадлежит:
The present invention provides compounds of Formula I, 2. A compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein each of Aand Ais claim 1 , independently claim 1 , CR.3. A compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein each Ris independently H or F.4. A compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 1', 'b', 'b', 'b', '1, 'sub': 1-6', '1-6', '1-6', '3', '2', '2', '3', '2', '2, 'Ris a ring selected from phenyl, pyridinyl or pyrimidinyl, wherein the ring is substituted with from 1 to 4 substituents independently selected from halo, —Calkyl, —OCalkyl, hydroxyCalkyl, —CF, —CHF, —CHF, —OCF, —OCHF, —OCHF, CN, —C(═O)NRR, —C(═O)OR, —OA or A, provided at least one substituent on Ris A or —OA; and'}{'sub': 1-6', '1-6', '1-6', '3', '2', '2', '3', '2', '2, 'sup': b', 'b, 'A is a 5 to 6 membered aryl or heteroaryl group, or a 4 to 6 membered N-linked heterocycloalkyl group, or a 3 to 6 membered cycloalkyl group, where the heteroaryl can have from 1 to 3 heteroatoms independently selected from O, N or S, the N-linked heterocycloalkyl can have 1 additional heteroatom independently selected from O, N or S, and the aryl, heteroaryl, heterocyclic and cycloalkyl group can be unsubstituted or substituted with from 1 to 4 substituents independently selected from halo, —Calkyl, —OCalkyl, hydroxyCalkyl —CF, —CHF, —CHF, —OCF, —OCHF, —OCHF, —CN, or —C(═O)NRR.'}5. A compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris a phenyl ring or pyridyl ring claim 1 , wherein the ring is substituted with from 1 to 4 substituents independently selected from halo claim 1 , —Calkyl claim 1 , —OCalkyl claim 1 , hydroxyCalkyl claim 1 , —CF claim 1 , —CHF claim 1 , —CHF claim 1 , —OCF claim 1 , —OCHF claim 1 , —OCHF claim 1 , CN claim 1 , —C(═O)NRR—C(═O)OR claim 1 , —OA or A claim 1 , provided ...
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