21-03-2013 дата публикации
Номер: US20130072506A1
Принадлежит:
6,8-Disubstituted purines which can be used in drug and cosmetic compositions and/or applications are provided. These 6,8-disubstituted purines have a wide range of biological activities, including for example anti-inflammatory, anti-senescent, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. The 6,8-disubstituted purine compounds and compositions containing such 6,8-disubstituted purines provide growth-regulatory, differentiating, antisenescent and antiaging properties with improved selectivities and efficiencies and lower toxicities than analogues known heretofore. 2. The 6 claim 1 ,8-disubstituted purines of claim 1 , wherein Ris selected from the group consisting of furfuryl claim 1 , phenyl claim 1 , benzyl claim 1 , 3-methylbut-2-en-1-yl claim 1 , cyclohexylmethyl claim 1 , allyl claim 1 , and 3 claim 1 ,3-dimethylallyl claim 1 , wherein the selected Rcan be unsubstituted or substituted with one or more halogen claim 1 , hydroxy claim 1 , methoxy claim 1 , methyl claim 1 , amino claim 1 , nitro or combinations thereof.3. The 6 claim 1 ,8-disubstituted purines of claim 1 , wherein R8 is selected from the group consisting of amino claim 1 , hydroxy claim 1 , chloro claim 1 , fluoro claim 1 , bromo claim 1 , amino(C-Calkyl)amino claim 1 , hydroxy(C-Calkyl)amino claim 1 , NHOH claim 1 , NHNH claim 1 , carboxyl claim 1 , nitro claim 1 , sulphanyl claim 1 , methylsulphanyl claim 1 , and methoxy.4. The 6 claim 3 ,8-disubstituted purines of claim 3 , wherein R8 is amino.5. The 6 claim 1 ,8-disubstituted purines of claim 1 , wherein the 6 claim 1 ,8-disubstituted purines are 6-furfurylamino-8-(amino claim 1 , hydroxy claim 1 , chloro claim 1 , fluoro claim 1 , bromo claim 1 , amino(C-Calkyl)amino claim 1 , hydroxy(C-Calkyl)amino claim 1 , NHOH claim 1 , NHNH claim 1 , carboxyl claim 1 , nitro claim 1 , sulphanyl claim 1 , methylsulphanyl claim 1 , methoxy)purine claim 1 , 6-(3-hydroxybenzylamino)-8-(amino ...
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