Novel compounds as GLP-1 agonists
(19)AUSTRALIAN PATENT OFFICE (54) Title Novel compounds as GPL-I agonists (51)6 International Patent Classification(s) C07K 14/605 20060101AFI2007101 (2006.01) 8BHEP C07K 14/605 PCT/IN2006/000154 (21) Application No: 2006277557 (22) Application Date: 2006.05.04 (87) WIPONo: WO07/017892 (30) Priority Data (31) Number (32) Date (33) Country 645/MUM/2005 2005.05.31 IN 558/MUM/2005 2005.05.05 IN (43) Publication Date : 2007.02.15 (71) Applicant(s) Cadila Healthcare Limited (72) Inventor(s) Lohray, Braj Bhushan; Lohray, Vidya Bhushan; Bahekar, Rajesh H. (74) Agent/Attorney Lesicar Perrin, 49 Wright Street Adelaide, SA, 5000 (H) Application NoAU2006277557 A1(19)AUSTRALIAN PATENT OFFICE (54) Title Novel compounds as GPL-I agonists (51)6 International Patent Classification(s) C07K 14/605 20060101AFI2007101 (2006.01) 8BHEP C07K 14/605 PCT/IN2006/000154 (21) Application No: 2006277557 (22) Application Date: 2006.05.04 (87) WIPONo: WO07/017892 (30) Priority Data (31) Number (32) Date (33) Country 645/MUM/2005 2005.05.31 IN 558/MUM/2005 2005.05.05 IN (43) Publication Date : 2007.02.15 (71) Applicant(s) Cadila Healthcare Limited (72) Inventor(s) Lohray, Braj Bhushan; Lohray, Vidya Bhushan; Bahekar, Rajesh H. (74) Agent/Attorney Lesicar Perrin, 49 Wright Street Adelaide, SA, 5000 The present invention describes a group of novel peptidomimetics useful for the treatment of diabetes. These compounds are defined by the general formula (I) as given below. A-X<SUB>1</SUB>- S<SUB>1</SUB>-Y-S<SUB>2</SUB>-X<SUB>2</SUB>-B (I) JJO-CHO-^JOUU We claim: 1. An isolated polypeptide having a sequence of Formula (I), including its tautomers, solvates and pharmaceutically acceptable salts A-Xi- S1-Y-S2-X2-B (I) wherein, A represents -NH-R1, wherein R1 represents hydrogen, groups selected from linear or branched (C1-C1S) alkyl chain, an amino acid or peptide containing one, two or three natural amino acid residues, R3-CO- group, RsO-C(O)- group, a sulfonyl group of formula Rs-SO2-, each of these groups may be substituted; R3 is selected from linear or branched (C1-C1O) alkyl, (C3-C6) cycloalkyl, aryl, heteroaryl, arylalkyl groups, each of these groups may be substituted; B represents -COOR2, -CONHR2 or CH2OR2, R2 represents H, groups selected from linear or branched (Ci-C10) alkyl, aryl groups selected from phenyl, napthyl, indanyl, fluorenyl, biphenyl groups, aralkyl group, wherein the aryl groups are as defined earlier, each of these groups may be substituted; each of S1 and S2 may independently be a bond or independently represents a group '- NH-(CH2)n-C00-', where, n=l-9; Y represents a bond or -CO-, -(CH2)m- (m = 1-3), '0',1S', -CO-NH-, -CO-NR4-, or represents a short peptide containing one or two or three amino acids selected from natural or non-natural amino acids; where R4 represents H, optionally substituted groups selected from linear or branched (C1-C1O) alkyl or aryl groups selected from phenyl, napthyl, indanyl, fluorenyl, biphenyl groups; with the proviso that when S1-Y- S2 represents a bond, X1 is selected from the following amino acid sequences HAEGTFTSD, HAEGTFTSDV, HAEGTFTSDVS, HAEGTFTSDVSS, HAEGTFTSDVSSY, HAEGTFTSDVSSYL, HAEGTFTSDVSSYLE, HAEGTFTSDVSSYLEG, HAEGTFTSDVSSYLEGQ, HAEGTFTSDVSSYLEGQA, HAEGTFTSDVSSYLEGQAA, HAEGTFTSDVSSYLEGQAAK, HAEGTFTSDVSSYLEGQAAICE, HAEGTFTSDVSSYLEGQAAKEF, HAEGTFTSDVSSYLEGQAAKEFI, with the further option that one or more of these amino acids may be replaced by unnatural amino acids, and X2 is selected from the following amino acid sequences GPSSGAPPPS or KELEKLL or
GPPS or VKGR; and when S1-Y-S2 does not represent a bond X1 is selected from the following amino acid sequences HA, HAE, HAEG, HAEGT, HAEGTF, HAEGTFT, HAEGTFTS, HAEGTFTSD with the further option that one or more of these amino acids may be replaced by unnatural amino acids; X2 is selected from GPSSGAPPPS or KELEKLL or GPPS or VKGR or a dipeptide, selected from combination of two amino acids consisting of natural or unnatural amino acids, having a side chain containing an arylalkyl or heterorylalkyl moieties selected from benzyl, napthylmethyl, pyridylmethyl, thienylmethyl, furylmethyl, imidazolylmethyl, isooxazolylmethyl, quinolylmethyl, benzofuranylmethyl, benzothienylmethyl, indolinylmethyl, indolylmethyl, dibenzofuranylmethyl, dibenzothienylmethyl, benzodihydrofuranylmethyl, benzodihydrothienylmethyl, thienopyrimidylmethyl, benzimidazolylmethyl, phenanthrenylmethyl, dihydrophenanthrenylmethyl, fluorenylmethyl, dibenzofuranylmethyl, dibenzothiophenyl methyl groups, where each of these groups may be optionally substituted with (C1-C6)alkyl, (Q-C^alkoxy, cyano, halo, hydroxy or optionally substituted aryl or heteroaryl groups, with the further provision that such aryl or heteroaryl substituents may further be optionally substituted with (Cj-C6)alkyl, (Ci-C6)alkoxy, cyano, halo, hydroxy or aryl or heteroaryl groups. 2. A compound as claimed in claim 1 wherein the non-natural amino acids are represented by the general formula (Ha)
wherein R5 is selected from H, F, (C1-Cs) alkyl, the stereochemical configuration at the carbon bearing R5 may be (R) or (S); R6 is selected from H or (C1-C3) alkyl; each of R7 and R$ is independently selected from H, (C1-C2) alkyl or halogen atom, preferably fluorine atom; R9 represents groups, selected from (C1-Cs) alkyl, aryl or heteroryl moieties selected from phenyl, napthyl, pyridyl, thienyl, furyl, imidazolyl, isooxazolyl, quinolyl, benzofuranyl, benzothienyl, indolinyl, indolyl, dibenzofuranyl, dibenzothienyl, benzodihydrofuranyl, benzodihydrothienyl, thienopyrimidyl, benzimidazolyl, phenanthrenyl, dihydrophenanthrenyl, fluorenyl, dibenzofuranyl, dibenzothiophenyl groups, where each of these groups may be optionally substituted with (C1-C6) alkyl, (C1-C6) alkoxy, cyano, halo, hydroxy or optionally substituted aryl or heteroaryl groups, with the further provision that such aryl or heteroaryl substituents may further be optionally substituted with (C1- C6)alkyl, (d-C6)alkoxy, cyano, halo, hydroxy or aryl or heteroaryl groups. 3. The isolated peptide as claimed in claim 1, wherein the dipeptide representing X2 is preferably selected from Bip, Bip(2-Me), Biρ(2-Et), Bip(2-Ipr), Bip(2-CN), Bip(2'- Et-4'-OMe), Bip(4'-fluoro), Bip(4'-Phenyl), 2-(9,10-Dihydro-phenanthrenyl]-Ala, 2-(Phenanthrenyl)-Ala, 4-(2-Naphthyl)-Phe, 4-(l-Naphthyl)-Phe, 2-Fluorenyl-Ala, 4-dibenzofuran-Phe, 4-dibenzothiophene-Phe, 4-(2'-methylρhenyl)-3-pyridylalanine groups. 4. The isolated peptide as claimed in claim 1, wherein the substituents are selected from hydroxyl, oxo, halo, thio, nitro, amino, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, aryl, aryloxy, aralkyl, aralkoxy, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, carboxylic acid and its derivatives selected from esters and amides. 5. The isolated polypeptide of claim 1, wherein the isolated polypeptide is a compound selected from HGEGTFTSD-(CH2)3-GPSSGAPPPS HGEGTFTSD-(CH2)4-GPSSGAPPPS HGEGTFTSD-(CH2)s-GPSSGAPPPS HGEGTFTSD-(CH2)6-GPSSGAPPPS HGEGTFTSD-(CH2)7-GPSSGAPPPS
HGEGTFTSD-(CH2)10-GPSSGAPPPS HGEGTFTSD-(CH2)n-GPSSGAPPPS HGEGTFTSDLSKQM-(CH2)3-GPSS HGEGTFTSDLSKQM-(CH2)4-GPSS HGEGTFTSDLSKQM-(CH2)5-GPSS HGEGTFTSDLSKQM-(CH2)6-GPSS HGEGTFTSDLSKQM-(CH2)7-GPSS HGEGTFTSDLSKQM-(CH2)IO-GPSS HGEGTFTSDLSKQM-(CH2)Π-GPSS HGEGTFTSDLSKQME-G-GPSSGAPPP1S HGEGTFTSDLSKQME-(CH2)2-GPSSGAPPPS HGEGTFTSDLSKQME-(CH2)3-GPSSGAPPPS HGEGTFTSDLSKQME-(CH2)4-GPSSGAPPPS HGEGTFTSDLSKQME-(CH2)5-GPSSGAPPPS HGEGTFTSDLSKQME-(CH2)6-GPSSGAPPPS HGEGTFTSDLSKQME-(CH2)7-GPSSGAPPPS HGEGTFTSDLSKQME-(CH2)1o-GPSSGAPPPS HGEGTFTSDLSKQME-(CH2)π-GPSSGAPPPS HAEGTFTSD-(CH2)2-VKGR HAEGTFTSD-(CH2)3-VKGR HAEGTFTSD-(CH2)4-VKGR HAEGTFTSD-(CH2)5-VKGR HAEGTFTSD-(CH2)6-VKGR HAEGTFTSD-(CH2)IO-VKGR HAibEGTFTSD-(CH2)2-VKGR HAibEGTFTSD-(CH2)3-VKGR HAibEGTFTSD-(CH2)4-VKGR HAibEGTFTSD-(CH2)s-VKGR HAibEGTFTSD-(CH2)6-VKGR HAibEGTFTSD-(CH2)10-VKGR HGEGTFTSDLSKQMKELEKLL HAEGTFTSDKELEKLL HGEGTFTSDKELEKLL HAibEGTFTSDGKELEKLL
HGEGTFTSDGKELEKLL HGEGTFTSDVSKELEKLL HAEGTFTSDVSKELEKLL HAEGTFTSDVSEKELEKLL HAEGTFTSDVSGKELEKLL HAEGTFTSDVSSYLEKELEKLL HAEGTFTSDVSSYLEGKELEKLL HGEGTFTSDVSSYLEGKELEKLL HaEGTFTSDVSSYLEGKELEKLL HAibEGTFTSDVSSYLEGKELEKLL HAEGTFTSDVSSYLEGKELEKLLVKG HAEGTFTSDVSSYLEPKELEKLL HAEGTFTSDVSSYLEGQAAKELEKLL HAEGTFTSDVSSYLEGQAAKEFIKELEKLL HAIBEGTFTSDVSSYLEGQAAKEFIKELEKLL HAibEGT-(α-Me)Phe(2-F)-TSDVSSYLEGQAAKEFIKELEKLL Des-amino-HAibEGT-(α-Me)Phe(2-F)-TSDVSSYLEGQAAKEFIKELEKLL HAEGTFTSD-(CH2)3-KELEKLL HAEGTFTSD-(CH2)4-KELEKLL HAEGTFTSD-(CH2)S-KELEKLL HAEGTFTSD-(CH2)6-KELEKLL HA-(CH2)3-DVSSYLEGQAAKEFIKELEKLL HAib-(CH2)3-DVSSYLEGQAAKEFIKELEKLL HAibEGTFTSDVSSYLEGQ-(CH2)2-KELEKLL HAibEGTFTSDVSSYLEGQ-(CH2)3-KELEKLL HAibEGTFTSDVSSYLE-(CH2)2-FIKELEKLL HGEGTFTSD-(CH2)3-Bip-Bip HAibEGTFTSD-(CH2)3-Bip-Bip HAibEGT-(α-Me)-Phe(2-F)-TSD-(CH2)3-Bip-Bip HAEGTFTSD-G-Bip(2-Me)-Bip(2-Me) HAibEGTFTSD-G-Bip(2-Me)-Bip(2-Me) HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Biρ(2-Me)-Bip(2-Me) HAEGTFTS-G-Bip(2-Me)-Bip(2-Me) HAibEGTFTS-G-Bip(2-Me)-Bip(2-Me)
HAibEGT-(α-Me)-Phe(2-F)-TS-G-Bip(2-Me)-Bip(2-Me) HAEGTFTS-(CH2)2-Biρ(2-Me)-Bip(2-Me) HAibEGTFTS-(CH2)2-Bip(2-Me)-Bip(2-Me) HAibEGT-(α-Me)-Phe(2-F)-TS-(CH2)2-Bip(2-Me)-Bip(2-Me) HAEGTFT-(CH2)2-Bip(2-Me)-Bip(2-Me) HAibEGTFT-(CH2)2-Bip(2-Me)-Bip(2-Me) HAibEGT-(α-Me)-Phe(2-F)-T-(CH2)2-Bip(2-Me)-Bip(2-Me) HAEGTF-(CH2)2-Bip(2-Me)-Bip(2-Me) HAibEGTF-(CH2)2-Bip(2-Me)-Bip(2-Me) HAibEGT-(α-Me)-Phe(2-F)-(CH2)2-Bip(2-Me)-Bip(2-Me) HAEGT-(CH2)2-Bip(2-Me)-Bip(2-Me) HAibEGT-(CH2)2-Bip(2-Me)-Bip(2-Me) HAEG-(CH2)2-Bip(2-Me)-Bip(2-Me) HAibEG-(CH2)2-Bip(2-Me)-Bip(2-Me) HAEGTFTSD-(CH2)2-Bip(2-Me)-Bip(2-Me) HAibEGTFTSD-(CH2)2-Bip(2-Me)-Bip(2-Me) HAibEGT-(α-Me)-Phe(2-F)-TSD-(CH2)2-Bip(2-Me)-Bip(2-Me) HAEGTFTSD-G-Bip-Bip(2-Me) HAibEGTFTSD-G-Bip-Bip(2-Me) HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Bip-Bip(2-Me) HAEGTFTSD-G-Bip(2-Me)-Bip HAibEGTFTSD-G-Bip(2-Me)-Bip HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Bip(2-Me)-Bip HAEGTFTSD-G-Bip-Bip HAibEGTFTSD-G-Bip-Bip HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Biρ-Bip HAEGTFTSD-G-Bip-Bip(2-Et) HAibEGTFTSD-G-Bip-Bip(2-Et) HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Bip-Bip(2-Et) HAEGTFTSD-G-Bip(2-Et)-Bip(2-Et) HAibEGTFTSD-G-Bip(2-Et)-Biρ(2-Et) HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Bip(2-Et)-Bip(2-Et) HAEGTFTSD-G-Bip(2-Et)-Bip HAibEGTFTSD-G-Bip(2-Et)-Bip
HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Bip(2-Et)-Bip HAEGTFTSD-G-Bip(2-Et)-Bip(2-Me) HAibEGTFTSD-G-Bip(2-Et)-Bip(2-Me) HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Bip(2-Et)-Bip(2-Me) HAEGTFTSD-G-Bip(2-Me)-Bip(2-Et) HAibEGTFTSD-G-Bip(2-Me)-Bip(2-Et) HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Bip(2-Me)-Bip(2-Et) HGEGTFTSD-G-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TSD-G-Bip(2-Me)-Bϊp(2-Me) HGEGTFTSD-G-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TSD-G-Bip(2-Et)-Bip(2-Et) HGEGTFTSD-(CH2)3-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)3-Bip(2-Me)-Bip(2-Me) HGEGTFTSD-(CH2)4-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)4-Bip(2-Me)-Bip(2-Me) HGEGTFTSD-(CH2)5-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)5-Bip(2-Me)-Bip(2-Me) HGEGTFTSD-(CH2)6-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)6-Bip(2-Me)-Bip(2-Me) HGEGTFTSD-(CH2)10-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)10-Bip(2-Me)-Bip(2rMe) HGRCτTFTSD-(CH2)3-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)3-Bip(2-Et)-Bip(2-Et) HGEGTFTSD-(CH2)4-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)4-Bip(2-Et)-Bip(2-Et) HGEGTFTSD-(CH2)5-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)5-Bip(2-Et)-Bip(2-Et) HGEGTFTSD-(CH2)6-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)6-Bip(2-Et)-Bip(2-Et) HGEGTFTSD-(CH2)10-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)io-Bip(2-Et)-Bip(2-Et) HGEGTFTSD-(CH2)! i-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)π-Bip(2-Et)-Bip(2-Et)
HGEGTFTS-(CH2)3-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)3-Bip(2-Me)-Bip(2-Me) HGEGTFTS-(CH2)4-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)4-Bip(2-Me)-Bip(2-Me) HGEGTFTS-(CH2)5-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)5-Bip(2-Me)-Bip(2-Me) HGEGTFTS-(CH2)6-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)6-Bip(2-Me)-Bip(2-Me) HGEGTFTS-(CH2)io-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)io-Bip(2-Me)-Bip(2-Me) HGEGTFTS-(CH2)π-Biρ(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)n-Bip(2-Me)-Bip(2-Me) HGEGTFTS-(CH2)3-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)3-Bip(2-Et)-Biρ(2-Et) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)4-Bip(2-Et)-Bip(2-Et) HGEG1TTS-(CH2)4-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)4-Bip(2-Et)-Bip(2-Et) HGEGTFTS-(CH2)5-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)5-Bip(2-Et)-Bip(2-Et) HGEGTFTS-(CH2)6-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)6-Bip(2-Et)-Bip(2-Et) I-IGEGTFTS-(CII2)lϋ-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)10-Bip(2-Et)-Bip(2-Et) HGEGTFTS-(CH2)π-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)jrBip(2-Et)-Bip(2-Et) HGEGTFTS-(CH2)2-Bip(2-Me)-Bip(2-Me) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)2-Bip(2-Me)-Bip(2-Me) HGEGTFTS-(CH2)2-Bip(2-Et)-Bip(2-Et) HGEGT-(α-Me)-Phe(2-F)-TS-(CH2)2-Bip(2-Et)-Biρ(2-Et) HAEGTFTS-(CH2)2-Bip(2-Et)-Bip(2-Et) HAibEGTFTS-(CH2)2-Bip(2-Et)-Bip(2-Et) HAibEGT-(α-Me)-Phe(2-F)-TS-(CH2)2-Bip(2-Et)-Bip(2-Et) HGEGTFTSD-(CH2)2-Bip(2-Et)-Bip(2-Et)
HGEGT-(α-Me)-Phe(2-F)-TSD-(CH2)2-Bip(2-Et)-Bip(2-Et) HAEGTFTSD-(CH2)2-Bip(2-Et)-Bip(2-Et) HAibEGTFTSD-(CH2)2-Bip(2-Et)-Bip(2-Et) HAibEGT-(α-Me)-Phe(2-F)-TSD-(CH2)2-Bip(2-Et)-Bip(2-Et) HAEGTF-(CH2)2-Biρ(2-Me)-Bip(2-Et) HAibEGTF-(CH2)2-Bip(2-Me)-Bip(2-Et) HAibEGT-(α-Me)-Phe(2-F)-(CH2)2-Bip(2-Me)-Bip(2-Et) HAEGTFTSD-G-TrPh-TrPh HAibEGTFTSD-G-TrPh-TrPh HAibEGT-(α-Me)-Phe(2-F)-TSD-G-TrPh-TrPh HAibEGT-(α-Me)-Phe(2-F)-(CH2)2-TrPh-TrPh HAibEG-(CH2)2-TrPh-TrPh HAibE-(CH2)2-TrPh-TrPh HAib-(CH2)3-TrPh-TrPh HAEGTFTSD-G-Nap-Nap HAibEGTFTSD-G-Naρ-Nap HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Nap-Nap HAEGTFTSD-G-Bip(2-F)-Bip(2-F) HAibEGTFTSD-G-Bip(2-F)-Bip(2-F) AibEGT-(α-Me)-Phe(2-F)-TSD-G-Bip(2-F)-Bip(2-F) HAEGTFTSD-G-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEGTFTSD-G-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEGT-(α-Me)-Phe(2-F)-TSD-G-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAEGTFTSD-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEGTFTSD-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEGT-(α-Me)-Phe(2-F)-TSD-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa HAEGTFTS-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEGTFTS-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEGT-(α-Me)-Phe(2-F)-TS-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- Ala HAEGTFT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEGTFT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala
HAibEGT-(α-Me)-Phe(2-F)-T-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAEGTF-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEGTF-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEGT-(α-Me)-Phe(2-F)-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAEGT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEGT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAEG-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEG-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAEG-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAibEG-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala HAEGT-(CH2)2-Bip(2-Me)-Bip(2-Me) HGEGT-(CH2)3-Bip(2-Me)-Bip(2-Me) HGEGT-(CH2)4-Bip(2-Me)-Bip(2-Me) HGEGT-(CH2)5-Bip(2-Me)-Bip(2-Me) HGEGT-(CH2)6-Bip(2-Me)-Bip(2-Me) HAEGT-(CH2)2-Bip(2-Me)-DBiρ(2-Me) HAEGT-(CH2)2-DBip(2-Me)-Bip(2-Me) HaEGT-(CH2)2-Bip(2-Me)-Bip(2-Me) HGEG-(CH2)3-Bip(2-Me)-Bip(2-Me) HAEG-(CH2)3-Bip(2-Me)-Bip(2-Me) HGEG-(CH2)4-Bip(2-Me)-Bip(2-Me) HGEG-(CH2)5-Bip(2-Me)-Bip(2-Me) HGEG-(CH2)0-Biρ(2-Me)-Bip(2-Me) HAEG-(CH2)3-Bip(2-Et)-Biρ(2-Me) HAEG-(CH2)3-Bip(2-Me)-DBip(2-Me) HAEG-(CH2)4-Bip(2-Me)-DBip(2-Me) HAEG-(CH2)5-Biρ(2-Me)-DBip(2-Me) HGEG-(CH2)5-DBip(2-Me)-Bip(2-Me) HAE-(CH2)3-Bip(2-Me)-Bip(2-Me) HAE-(CH2)3-Bip(2-Me)-DBiρ(2-Me) HAE-(CH2)2-D-Biρ(2-Me)-Bip(2-Me) HAE-(CH2)3-D-Bip(2-Me)-Bip(2-Me) HAE-(CH2)4-D-Biρ(2-Me)-Bip(2-Me) HAE-(CH2)4-Biρ(2-Me)-DBiρ(2-Me)
HAE-(CH2)5-D-Bip(2-Me)-Bip(2-Me) HAE-(CH2)3-Biρ(2-Et)-Bip(2-Me) HAE-(CH2)2-Bip(2-Me)-Bip(2-Me) H-(CH2)3-Bip(2-Me)-Bip(2-Me) H-(CH2)4-Bip(2-Me)-Bip(2-Me) H-(CH2)5-Bip(2-Me)-Bip(2-Me) H-(CH2)3-Bip(2-Et)-Bip(2-Me) H-(CH2)4-Bip(2-Et)-Bip(2-Me) H-(CH2)5-Bip(2-Et)-Bip(2-Me) H-(CH2)6-Bip(2-Et)-Biρ(2-Me) H-(CH2)10-Bip(2-Et)-Bip(2-Me) H-(CH2)5-Bip(2-Me)-DBip(2-Me) H-(CH2)5-DBip(2-Me)-Bip(2-Me) H-(CH2)5-DBip(2-Me)-DBip(2-Me) HG-(CH2)3-Bip(2-Me)-Bip(2-Me) HG-(CH2)4-Bip(2-Me)-Bip(2-Me) HG-(CH2)3-Bip(2-Et)-Bip(2-Me) HG-(CH2)4-Bip(2-Et)-Bip(2-Me) HG-(CH2)3-Bip(2-Et)-DBip(2-Me) HG-(CH2)3-Bip(2-Me)-DBip(2-Me) FA-(CH2)3-DBip(2-Me)-Bip(2-Et) FA-(CH2)3-DBip-Dbip Ha-(CH2)3-Bip(2-Me)-Bip(2-Me) Ha-(CH2)4-Bip(2-Me)-Bip(2-Me) Ha-(CH2)5-Bip(2-Me)-Bip(2-Me) Ha-(CH2)3-Bip(2-Et)-Bip(2-Me) Ha-(CH2)3-Bip(2-Et)-DBiρ(2-Me) Ha-(CH2)3-Bip(2-Me)-DBip(2-Me) Ha-(CH2)3-Blp(2-Et)-DBip(2-Et) Ha-(CH2)3-Bip(2-Me)-Bip Ha-(CH2)3-(N(Me))-DBip(2-Me)-Bip(2-Et) Ha-(CH2)3-(N(Me))-Bip(2-Et)-Bip(2-Me) Ha-(CH2)3-(N(Me))-DBip-Bip(2-Et) Ha-(CH2)3-DBip(2-Me)-Bip(2-Et)
HA-(CH2)3-Bip(2-Me)-Bip(2-Me) HA-(CH2)4-Bip(2-Me)-Bip(2-Me) HA-(CH2)5-Bip(2-Me)-Biρ(2-Me) HA-(CH2)6-Bip(2-Me)-Bip(2-Me) HA-(CH2)i0-Bip(2-Me)-Bip(2-Me) HA-(CH2)!1-Bip(2-Me)-Bip(2-Me) HA-(CH2)3-Bip(2-Et)-Bip(2-Me) HA-(CH2)3-Bip(2-Et)-DBip(2-Et) HA-(CH2)3-DBip(2-Me)-DBip(2-Me) HA-(CH2)3-DBip(2-Me)-Bip(2-Me) HA-(CH2)3-Bip(2-Me)-DBip(2-Me) HA-(CH2)3-Bip(2-Ipr)-Bip(2-Ipr) HA-(CH2)3-Bip(2-Ipr)-Bip(2-Me) HA-(CH2)3-Bip(2-Me)-Bip(2-Ipr) HA-(CH2)4-Bip(2-Et)-Bip(2-Me) HA-(CH2)3-Bip(2-Me)-DBip(2-Et) HA-(CH2)2-Bip(2-Et)-Bip(2-Me) HA-(CH2)5-Bip(2-Et)-Bip(2-Me) HA-(CH2)6-Bip(2-Et)-Bip(2-Me) HA-(CH2)2-Bip(2-Me)-Bip(2-Me) HA-(CH2)3-DBip(2-Et)-DBip(2-Me) HA-(CH2)3-DBip(2-Et)-Biρ(2-Me) HA-(CH2)2-Bip(2-Me)-DBip(2-Me) HA-(CH2)3-Bip(2-Et)-Bip(2-Et) HA-(CH2)3-DBip(2-Et)-DBiρ(2-Et) HA-(CH2)3-DBip(2-Et)-Biρ(2-Et) HA-(CH2)3-DBip(2-Me)-DBip(2-Et) HA-(CH2)3-Bip(2-Me)-Bip(2-Et) HA-(CH2)3-DBip(2-Me)-Bip(2-Et) HA-(CH2)3-Bip-Bip HA-(CH2)3-Bip-D-Bip HA-(CH2)3-DBip-D-Bip HA-(CH2)3-DBip-Bip HA-(CH2)3-Bip-Bip(2-Me)
HA-(CH2)3-Bip(2-Me)-Bip HA-(CH2)3-Bip(2-Et)-Bip HA-(CH2)3-Bip-Bip(2-Et) HA-(CH2)3-Bip(2-Ipr)-DBip(2-Iρr) HA-(CH2)3-DBip(2-Ipr)-Bip(2-Ipr) HA-(CH2)3-DBip(2-Ipr)-DBip(2-Ipr) HA-(CH2)3-Bip(2-Me)-Bip(2-CN) HA-(CH2)3-Bip-Bip(2-CN) HA-(CH2)3-Bip(2-Et)-Bip(2-CN) HA-(CH2)3-Bip(2-Ipr)-Biρ(2-CN) HA-(CH2)3-Bip(2-CN)-Bip(2-Me) HA-(CH2)3-Bip(2-CN)-Bip HA-(CH2)3-Bip(2-CN)-Bip(2-Et) HA-(CH2)3-Bip(2-CN)-Bip(2-Ipr) HA-(CH2)3-Bip(2-CJN)-Biρ(2-CN) HA-(CH2)2-F-(CH2)2-Bip(2-Et)-DBip(2-Et) HA-(CH2)2-F-(CH2)2-Bip(2-Et)-DBip(2-Me) HA-(CH2)5-Bip(2-Me)-DBiρ HA-(CH2)3-Bip(2-Me)-DBip-R HA-(CH2)3-DBip(2-Me)-DBip HA-(CH2)5-Bip(2-Me)-DBip(2-Me) HA-(CH2)5-DBip(2-Me)-Bip(2-Me) HA-(CH2)4-D(Bip)-Bip(2-Et) HA-(CH2)5-D(Bip)-Bip(2-Et) HA-(CH2)4-Bip(2-Me)-DBip(2-Me) HA-(CH2)5-Bip(2-Me)-DBip(2-Me) HA-(CH2)3-(N(Me))-DBip-Bip(2-Et) HA-(CH2)4-DBip(2-Me)-Bip(2-Et) HA-(CH2)5-DBip(2-Me)-Bip(2-Et) HA-(CH2)3-(N(Me))-DBip(2-Me)-Bip(2-Et) HA-(CH2)4-Bip(2-Me)-DBip HA-(CH2)5-Bip(2-Me)-DBip HA-(CH2)3-(N(Me))-Bip(2-Et)-Bip(2-Me) HA-(N(Me))-(CH2)3-DBip(2-Me)-Bip(2-Et)
HA-(N(Me))-(CH2)3-DBip-Bip(2-Et) HA-(N(Me))-(CH2)3-Bip(2-Et)-Bip(2-Me) HA-(N(Me))-(CH2)3-Bip(2-Me)-DBip HAE-(CH2)2-F-(CH2)2-Bip(2-Et)-DBip(2-Et) HAE-(CH2)2-F-(CH2)2-Bip(2-Et)-DBip(2-Me) HAib-(CH2)3-(N(Me))-Bip(2-Et)-Bip(2-Me) 6. The isolated polypeptide of claim 1 wherein the isolated polypeptide is a compound selected from HA-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-Aib-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 Ha-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))Aib-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-NH2 H-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-NH2 H-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-NH2 H-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4- (2'-Me-Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me»- 4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-NH-(CH2)6-CH3 H-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 H-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Biρ(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-NH-(CH2)10-CH3
H-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)i0-CH3 CH3-(CH2)6-NH-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)6-NH-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Biρ(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)10-NH-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NΗ-(CH2)6-CH3 CH3-(CH2)1o-NH-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 HA-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-Aib-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 Ha-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(N(Me))-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))Aib-(N(Me))-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-NH2 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-NH2 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-NH2 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4- (2'-Me-Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-NH-(CH2)6-CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-NH-(CH2)10-CH3
H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)i0-CH3 CH3-(CH2)6-NH-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)6-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)10-NH-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)io-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 HA-(CH2)4-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-Aib-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-a-(CH2)4-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NΗ2 H-(N(Me))A-(CH2)4-Biρ(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(N(Me))-(CH2)4-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))Aib-(N(Me))-(CH2)4-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-NH2 H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-NH2 H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-NH2 H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Biρ(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4- (2'-Me-Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-NH-(CH2)6-CH3 H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-NH-(CH2)10-CH3
H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)10-CH3 CH3-(CH2)6-NH-H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)6-NH-H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)io-NH-H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)10-NH-H-N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 HAE-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-Aib-E-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 HaE-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))AE-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))AE-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))Aib-E-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala- NH2 H-(N(Me))AE^(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-NH2 H-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3- Pyr-Ala-NH2 H-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH2 H-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Biρ(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 H-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)6-CH3
H-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)io-CH3 H-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)10-CH3 CH3-(CH2)6-NH-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)6-NH-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)io-NH-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)10-NH-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 HAEG-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-Aib-EG-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 HaEG-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))AEG-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))AEG-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))Aib-EG-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala- NH2 H-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-NH2 H-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3- Pyr-Ala-NH2 H-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH2 H-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)6-CH3
H-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 H-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)io-CH3 H-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-NH-(CH2)io-CH3 CH3-(CH2)6-NH-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)6-NH-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)io-NH-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)1o-NH-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 HAEGT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-Aib-EGT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 HaEGT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))AEGT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 H-(N(Me))AEGT-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala- NH2 H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala- NH2 H-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3- Pyr-Ala-NH2 H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3- Pyr-Ala-NH2 H-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH2 H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH2 Des-amino-H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH2
H-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 H-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-NH-(CH2)io-CH3 H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-NH-(CH2)io-CH3 CH3-(CH2)6-NH-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)6-NH-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Biρ(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)io-NH-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 CH3-(CH2)io-NH-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-NH-(CH2)6-CH3 HA-(CH2)3-Bip(2-Me)-Bip(2-Me)-NH2 H-Aib-(CH2)3-Bip(2-Me)-Bip(2-Me)-NH2 Ha-(CH2)3-Bip(2-Me)-Bip(2-Me)-NH2 H-(N(Me))A-(CH2)3-Bip(2-Me)-Bip(2-Me)-NH2 H-(N(Me))A-(N(Me))-(CH2)3-Bip(2-Me)-Bip(2-Me)-NH2 H-(N(Me))Aib-(N(Me))-(CH2)3-Bip(2-Me)-Bip(2-Me)-NH2 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Biρ(2-Me)-Biρ(2-Me)-NH2 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-Bip(2-Me)-NH2 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-NH2 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-NH2 Des-amino-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)- NH2 Des-amino-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2- Me)-NH2 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Biρ(2-Me)-(N(Me))-Bip(2-Me)-NH- (CH2)6-CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-NH- (CH2)6-CH3
H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-NH- (CH2)10-CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-NH- (CH2)I0-CH3 CH3-(CH2)6-NH-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))- Bip(2-Me)-NH-(CH2)6-CH3 CH3-(CH2)6-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))- Bip(2-Me)-NH-(CH2)6-CH3 CH3-(CH2)10-NH-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))- Bip(2-Me)-NH-(CH2)6-CH3 CH3-(CH2)10-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))- Bip(2-Me)-NH-(CH2)6-CH3 HA-(CH2)3-Bip(2-Et)-Bip(2-Me)-NH2 H-Aib-(CH2)3-Bip(2-Et)-Bip(2-Me)-NH2 Ha-(CH2)3-Bip(2-Et)-Bip(2-Me)-NH2 H-(N(Me))A-(CH2)3-Bip(2-Et)-Bip(2-Me)-NH2 H-(N(Me))A-(N(Me))-(CH2)3-Bip(2-Et)-Bip(2-Me)-NH2 H-(N(Me))Aib-(N(Me))-(CH2)3-Bip(2-Et)-Bip(2-Me)-NH2 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-Bip(2-Me)-NH2 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-Bip(2-Me)-NH2 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-NH2 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-NH2 Des-amino-H-(N(Me))A-(N(Me))-(CΗ?)r(N(Me))-Bi'p(2-F,t)-(N(Me))-Bip(2-Me)- NH2 Des-amino-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2- Me)-NH2 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-NH-(CH2)6- CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-NH- (CH2)6-CH3 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-NH-(CH2)io- CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-NH- (CH2)I0-CH3
CH3-(CH2)6-NH-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2- Me)-NH-(CH2)6-CH3 CH3-(CH2)6-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))- Bip(2-Me)-NH-(CH2)6-CH3 CH3-(CH2)10-NH-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2- Me)-NΗ-(CH2)6-CH3 CH3-(CH2)10-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))- Bip(2-Me)-NH-(CH2)6-CH3 HA-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-Aib-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH Ha-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH Η-(N(Me))A-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))Aib-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-OH H-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-OH H-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-OH H-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-OH . Des-amino-H-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4- (2'-Me-Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-COO-(CH2)io-CH3 H-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)io-CH3
CH3-(CH2)6-NH-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Biρ(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)6-NH-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)io-NH-(N(Me))A-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)io-NH-(N(Me))Aib-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 HA-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-Aib-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH Ha-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(N(Me))-(CH2)3-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))Aib-(N(Me))-(CH2)3-Biρ(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-OH H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-OH H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-OH H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Biρ(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4- (2'-Me-Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-COO-(CH2)10-CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2),o-CH3
CH3-(CH2)6-NH-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)6-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)10-NH-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Biρ(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)jo-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 HA-(CH2)4-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-Aib-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH Ha-(CH2)4-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(CH2)4-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(N(Me))-(CH2)4-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))Aib-(N(Me))-(CH2)4-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-OH H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-OH H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-OH H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4- (2'-Me-Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Biρ(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me-Ph)- 3-Pyr-Ala-COO-(CH2)io-CH3 H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)jo-CH3
CH3-(CH2)6-NH-H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)6-NH-H-(N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)10-NH-H-(N(Me))A-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)io-NH-H-N(Me))Aib-(N(Me))-(CH2)4-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 HAE-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-Aib-E-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH HaE-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))AE-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))AE-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)^3-Pyr-Ala-OH H-(N(Me))Aib-E-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-OH H-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3- Pyr-Ala-OH H-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-OH H-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))- 4-(2'-Me-Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Biρ(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Biρ(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)10-CH3 H-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)10-CH3
CH3-(CH2)6-NH-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)6-NH-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)io-NH-(N(Me))AE-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)10-NH-(N(Me))Aib-E-(N(Me))-(CH2)2-(N(Me))-Biρ(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 HAEG-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-Aib-EG-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH HaEG-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))AEG-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))AEG-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))Aib-EG-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala- OH H-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Biρ(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr- AIa-OH H-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3- Pyr-Ala-OH H-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-OH H-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)10-CH3
H-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-COO-(CH2)10-CH3 CH3-(CH2)6-NH-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)6-NH-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)10-NH-(N(Me))AEG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)10-NH-(N(Me))Aib-EG-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 HAEGT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-Aib-EGT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH HaEGT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))AEGT-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))AEGT-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala- OH H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3-Pyr-Ala- OH H-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3- Pyr-Ala-OH H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-4-(2'-Me-Ph)-3- Pyr-Ala-OH H-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-OH H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-OH Des-amino-H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-OH H-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3
H-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'-Me- Ph)-3-Pyr-Ala-COO-(CH2)io-CH3 H-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)-(N(Me))-4-(2'- Me-Ph)-3-Pyr-Ala-COO-(CH2)10-CH3 CH3-(CH2)6-NH-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)6-NH-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)10-NH-(N(Me))AEGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 CH3-(CH2)10-NH-(N(Me))Aib-EGT-(N(Me))-(CH2)2-(N(Me))-Bip(2'-Et-4'-OMe)- (N(Me))-4-(2'-Me-Ph)-3-Pyr-Ala-COO-(CH2)6-CH3 HA-(CH2)3-Bip(2-Me)-Biρ(2-Me)-OH H-Aib-(CH2)3-Bip(2-Me)-Bip(2-Me)-OH Ha-(CH2)3-Bip(2-Me)-Bip(2-Me)-OH H-(N(Me))A-(CH2)3-Bip(2-Me)-Bip(2-Me)-OH H-(N(Me))A-(N(Me))-(CH2)3-Bip(2-Me)-Bip(2-Me)-OH H-(N(Me))Aib-(N(Me))-(CH2)3-Bip(2-Me)-Bip(2-Me)-OH H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Biρ(2-Me)-Bip(2-Me)-OH H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-Bip(2-Me)-OH H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-OH H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-OH Des-amino-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)- OH Des-amino-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2- Me)-OH H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-COO- (CH2)6-CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-COO- (CHz)6-CH3 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-COO- (CH2)10-CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))-Bip(2-Me)-COO- (CHz)1O-CH3
CH3-(CH2)6-NH-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))- Bip(2-Me)-COO-(CH2)6-CH3 CH3-(CH2)6-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))- Bip(2-Me)-COO-(CH2)6-CH3 CH3-(CH2)10-NH-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))- Bip(2-Me)-COO-(CH2)6-CH3 CH3-(CH2)10-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Me)-(N(Me))- Bip(2-Me)-COO-(CH2)6-CH3 HA-(CH2)3-Bip(2-Et)-Bip(2-Me)-OH H-Aib-(CH2)3-Bip(2-Et)-Bip(2-Me)-OH Ha-(CH2)3-Bip(2-Et)-Bip(2-Me)-OH H-(N(Me))A-(CH2)3-Bip(2-Et)-Bip(2-Me)-OH H-(N(Me))A-(N(Me))-(CH2)3-Bip(2-Et)-Bip(2-Me)-OH H-(N(Me))Aib-(N(Me))-(CH2)3-Bip(2-Et)-Bip(2-Me)-OH H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-Bip(2-Me)-OH H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-Bip(2-Me)-OH H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-OH H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-OH Des-amino-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)- OH Des-amino-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Biρ(2-Et)-(N(Me))-Bip(2- Me)-OH H-(N(Me))A-(N(Mc))-(CH2)3-(N(Mc))-Bip(2-Et)-(N(Mc))-Bip(2-Mc)-COO- (CHa)6-CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-COO- (CH2)6-CH3 H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-COO- (CHa)10-CH3 H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2-Me)-COO- (CH2)IO-CH3 CH3-(CH2)6-NH-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2- Me)-COO-(CH2)6-CH3 CH3-(CH2)6-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))- Bip(2-Me)-COO-(CH2)6-CH3
CH3-(CH2)10-NH-H-(N(Me))A-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))-Bip(2- Me)-COO-(CH2)6-CH3 CH3-(CH2)10-NH-H-(N(Me))Aib-(N(Me))-(CH2)3-(N(Me))-Bip(2-Et)-(N(Me))- Bip(2-Me)-COO-(CH2)6-CH3 HA-(CH2)3-DVSSYLEGQAAKEFIKELEKLL HAib-(CH2)3-DVSSYLEGQAAKEFIKELEKLL HAibEGTFTSDVSSYLEGQ-(CH2)2-KELEKLL HAibEGTFTSDVSSYLEGQ-(CH2)3-KELEKLL HAibEGTFTSDVSSYLE-(CH2)2-FIKELEKLL HAibEGT-(α-Me)Phe(2-F)-TSDVSSYLE-(CH2)2-FIKELEKLL HAib-(CH2)3-VSSYLE-(CH2)2-FIKELEKLL HAib-(CH2)3-VSSYLE-(CH2)3-FIKELEKLL HAib-(CH2)3-YLE-(CH2)3-FIKELEKLL HAib-(CH2)4-YLE-(CH2)3-FIKELEKLL HAib-(CH2)4-YL-(CH2)3-FIKELEKLL HAib-(CH2)4-Y-(CH2)3-FIKELEKLL HAib-(CH2)4-FIKELEKLL HAib-(CH2)5-FIKELEKLL HAib-(CH2)6-FIKELEKLL HAib-(CH2)8-FIKELEKLL HAib-(CH2)3-VSSYLEGQ-(CH2)3-KELEKLL HAib-(CH2)3-VSSYLEG-(CH2)3-KELEKLL HAib-(CH2)3-VSSYLE-(CH2)4-KELEKLL HAib-(CH2)3-SSYLE-(CH2)4-KELEKLL HAib-(CH2)3-SYLE-(CH2)4-KELEKLL HAib-(CH2)3-YLE-(CH2)4-KELEKLL HAib-(CH2)3-YL-(CH2)4-KELEKLL HAib-(CH2)3-Y-(CH2)4-KELEKLL HAib-(CH2)5-KELEKLL HAib-(CH2)6-KELEKLL HAib-(CH2)8-KELEKLL
7. A pharmaceutical composition comprising compounds as claimed in claims 1-6 prepared according to the processes described herein and a suitable pharmaceutically acceptable carrier(s). 8. The compounds or their pharmaceutical compositions as claimed in claims 1-7, which possess the ability to mimic the biological activity of GLP-I, more preferably mimic the GLP-IR agonist activity. 9. The compounds or their pharmaceutical compositions as claimed in any of the claims 1-7, useful for the treatment or prevention of diseases wherein GLP-IR peptide plays a patho-physiological function. 10. A method of preventing or treating diseases caused by hyperlipidaemia, hypercholesteremia, hyperglycemia, hyperinsulinemia, elevated blood levels of free fatty acids or glycerol, hypertriglyceridemia, wound healing, obesity, impaired glucose tolerance, leptin resistance, insulin resistance, diabetic complications, such as nephropathy, retinopathy, neuropathy and cataracts, comprising administering an effective, non-toxic amount of compound of formula (I) as defined in any preceding claims to a patient in need thereof. 11. The method according to any preceding claims, wherein the disease is type 2 diabetes, impaired glucose tolerance, dyslipidaemia, hypertension, obesity, atherosclerosis, hyperlipidaemia, coronary artery disease, cardiovascular disorders and other diseases wherein insulin resistance is the underlying pathophysiological mechanism. 12. A medicine for treating/reducing any of the disease conditions described in any preceding claims which comprises administering a compound of formula (I), as defined in claims 1-7 and a pharmaceutically acceptable carrier, diluent, excipients or solvate to a patient in need thereof. 13. A medicine for treating/reducing any of the disease conditions described in any preceding claims which comprises administering a compound of formula (I), as defined in claims 1-7 in combination with a suitable DPP IV inhibitor, to a patient in need thereof. 14. Use of compounds of formula (I), alone or in combination with suitable DPP IV inhibitors, their pharmaceutical compositions and medicines containing them as defined in any previous claims as a medicament suitable for the treatment of diseases mentioned in any of the aforesaid claims.