Composite porous forming material for bone restoration, preparation method and application thereof
Technical Field The invention belongs to the field of preparation of gelatin derivative materials, in particular relates to gelatin, calcium phosphate, polylactic acid and active factor promoting (if antler polypeptide or bone morphogenetic protein ( MorphogeneticProtein Bone, BMP) for bone repair of the composite porous molding material, and method and the preparation of the material used in the bone, tooth repair application. Background Art Collagen degradation product of gelatin is, it not only maintain good the collagen as biological material some of the advantages of the unique, and compared with the collagen, gelatin non-antigenicity, without rejection reaction in vivo implanted; gelatin are cheap and easily obtained; it is easy to dissolve in water; its physical and chemical properties of the detection means has been the development of more mature, norms. Therefore, gelatin and calcium phosphate complex material at present bone repair material is also one of the hot spots in the study. Traditional gelatin and calcium phosphate complex mechanical material degradation rate of poor performance and serious defect of too fast, so that the composite material used in the bone repair there are still many problems. Polylactic acid as a has good biocompatibility of the degradable implant material, has already been applied to the clinical field, as a framework material can improve the gelatin, calcium phosphate composite material in mechanical and degradation of the performances of the defect. Research shows that: adding the polylactic acid material, the bone repair material can remarkably improve the mechanical performance and degrading rate (R.Zhang, P.X.Ma, Poly (α-hydroxyl acids)/ hydroxyapatite porouscomposites for bone-tissue engineering.I.Preparation andmorphology, J.Biomed.Mater.Res. 44, 1999, 446-455.), using the composite material has excipient performance, caused by implanting the bone defect can be of various different shapes of hole. Most importantly, the surface of the bone repair material having a large number of 200um hole of the above, and for the cells to grow to provide the necessary space, as a new generation of bone tissue engineering material is better able to play the role of osteogenic of the material. Active factor promoting, such as active antler polypeptide or bone morphogenetic protein (BMP) or bone inducing protein, can induce the undifferentiated mesenchymal cell differentiation to form cartilage and bone, Osteanaphysis repair is one of the most important factor, is now capable of extracting or recombinant BMP activity stabilized, however, if used alone the BMP local defect, is quickly be washed away by body fluid, necessary and a suitable carrier is combined with the local defect repairing and maintaining a certain concentration of sustained release, inducing osteogenic role to play, in the material preparation process of the present invention in promoting factor directly with the gelatin, calcium phosphate can be combined through the force, and the like, get evenly coated to promote bone activeness factor of the composite material, the localized sustained release function is realized, in the bone tissue engineering has wide application prospect. The Tsinghua University and cui Fuzhai (Patent application number: CN01141901.6) in stock solution in acid sol, prepared by the precipitation method collagen/calcium phosphate amorphous powder material, and then with the alginate mixed, forming, the strength and porosity of the film of reasonable implantable biodegradable bone material. Application yan Yongnian calcium phosphate powder and chitin/chitosan fiber complex (Patent application number: 200410034109.3), which also adds a small amount of collagen (gelatin), and bone morphology protein, the cells and animal experiment confirmed that the material has good biological activity and inducing osteogenesis activity. Such as south-east University li Xin pine (Patent application number: CN02138342.1) the biological can absorb the high molecular, un-sintered calcium phosphate, and the like dispersed in the high molecular of the mix in the good solvent, freeze drying to remove the solvent, to obtain the porous material, after being mixed with the live material for hard tissue repair by the active composition. This composition has the role of the promotion of bone healing, good biocompatibility. The invention first gelatin by an emulsification method, calcium phosphate, active material antler polypeptide or bone morphogenetic protein powder material, and then by adding the polylactic acid, after drying, the preparation of the film forming compound bone repair material, the bone repair composite porous molding material and the method for preparing the composite material also not see the literature reports. Content of the invention The purpose of this invention is to provide a good biocompatibility, degradation rate, the appropriate porosity containing antler polypeptide or bone morphogenetic protein (BMP), easy batch preparation, low price for bone repair of the composite porous molding material. Another purpose of this invention is to provide a composite used for repairing bone preparation method of the porous molding material. The present invention for repairing bone composite porous molding material, through the cell experiment and the animal experiment shows, the composite used for repairing bone is a porous molding material having good biocompatibility and inducing the bone repair material of the osteogenic activity. The present invention for repairing bone composite porous molding material is a polylactic acid as the frame, are uniformly dispersed in the framework of a gelatin, calcium phosphate and active material antler polypeptide or bone morphogenetic protein; wherein active substance antler polypeptide or bone morphogenetic protein is gelatin weight of the 1 [...] -10% ; calcium phosphate with gelatin the weight ratio of the 1 [...] the 20-4 [...] 1, poly-lactic acid and gelatin the weight ratio of the 1 [...] the 20-2 [...] 1. Gelatin is dispersed in the framework without cross-linked gelatin or after cross-linking agent cross-linking of the cross-linked gelatin; used for cross-linking the cross-linking agent is selected from glutaraldehyde, formaldehyde, dialdehyde glucose, equal beijing Nepal greater than or a mixture of more than one; the amount of cross-linking agent in the reaction the addition of cross-linking agent, which is added per gram of gelatin 30ul -1000ul cross-linking agent, cross-linking agent for the mass concentration of the 5 [...] -15%. The particle size of the calcium phosphate in 10 nm -1 mm; is selected from hydroxyapatite, tricalcium phosphate, calcium pyrophosphate , calcium biphosphate, calcium phosphate, tricalcium phosphate, calcium carbonate, or more than one kind of a mixture of more than one kind. For bone repair of the composite porous molding material of the diameter of the hole is 10 nm -1 mm. The present invention for repairing bone composite porous molding material preparation method comprises the following steps: 1) heating gelatin powder, adding de-ionized water (deionized water adding amount is the weight of the gelatin 4-20 times) swelling 10-60 minutes, and postheating to 35-70 the formed gelatin solution [...] , then added to the gelatin solution of calcium phosphate, calcium phosphate and calcium phosphate addition is the weight ratio of the 1 [...] the 20-4 [...] 1 ; subsequently, adding antler polypeptide or bone morphogenetic protein, antler polypeptide or bone morphogenetic protein to the addition of the weight of the 1 [...] -10% ; stirring 20-60 minutes, to obtain a multi-component mixed slurry; 2) step 1) into the mixed solution prepared by dissolving a surface active agent in the oil, stirring to form a water-in-oil emulsion; surface active agent content is in the oil of the oil -1g/20 ml 1g/200 ml oil; the amount of oil used per gram of gelatin 5 ml -250 ml; 3) step 2) water-in-oil emulsion prepared by heating, temperature control in the 35-70 the [...][...] , and continuously stirring, the stirring speed is 100 rpm/minute -6000 revolutions per minute; 4) under agitation, the steps 3) the obtained water-in-oil emulsion used for cooling ice; under the ice, gelatin gelation, are uniformly dispersed in the gelatin gel with calcium phosphate and antler polypeptide or bone morphogenetic protein; 5) to the cooling step after 4) in the reaction system by adding acetone or ethanol, acetone or ethanol is oil-in-water-in-oil emulsion in the volume of the moisture content 2-8 times, continuing to stir, filtering, consisting of gelatin, calcium phosphate, antler polypeptide or bone morphogenetic protein of crude bulk composite material; 6) step 5) the obtained composite material coarse article after repeated washing acetone, freeze-drying, consisting of gelatin, calcium phosphate, antler polypeptide or bone morphogenetic protein of the powdery composite material; 7) in step 6) the obtained powdery composite material of poly lactic acid solution is added, mix, wherein the polylactic acid with gelatin the weight ratio of the 1 [...] the 20-2 [...] 1; 8) step 7) mixing the homogeneous product fill the die, after the forming of the film to the material, and then in-5--20 the frozen [...] , by freeze drying, be used for repairing bone composite porous molding material. The cooling step after the 4) in the reaction system before adding acetone or ethanol, add cross-linking agent, cross-linking agent for the mass concentration of the 5 [...] -15%, the amount of cross-linking agent per gram of gelatin added 30ul -1000ul cross-linking agent. The surface active agent is a division of the series (SPAN) class (such as SPAN80, SPAN60 or SPAN20 and other) sodium dioctyl succinate surfactant or surface active agent (AOT) a in; the oil is selected from the group consisting of silicone oil, soybean oil, olive oil, camellia oil, rapeseed oil or mixed oil a, and the like. The polylactic acid solution as 1 ml solvent added 0.05-0.3g polylactic acid, poly-lactic acid solution the solvent is 1, 4-dioxane, acetone, dichloromethane, chloroform, ethyl acetate, or more than one kind of a mixture of more than one kind. The present invention for repairing bone composite porous molding material, through the cell experiment and animal experiment show that, the composite porous molding material has good biocompatibility and inducing osteogenesis activity, is a reliable in vivo degradable tissue repair and treating material, can be used as biological tissue (such as bone, cartilage, Bluetooth) in the repairing of material, has wide application value. Traditional powder gelatin of the invention, in order to obtain gelatin solution, and then added to the gelatin solution and calcium phosphate growth promoting adding various kinds of active substance (antler polypeptide or bone morphogenetic protein), is re-dispersed in oil bath into a gelatin solution in water-in-oil emulsion, gelatin is crosslinked through the, gelatin degrading ability further adjusted, and after the dehydration, eventually be used for repairing bone gelatin, calcium phosphate powdery composite material, to these powdery composite material of poly lactic acid solution is added, the powder of the polylactic acid composite material is uniformly dispersed in the solution, through the shaping, demoulding, freeze-drying, be used for repairing bone composite porous molding material, the surface of which has a hole, the cling and growth of the cells. Preparation of the present invention used for repairing bone in the composite porous molding material added with active antler polypeptide or bone morphogenetic protein, promotes bone marrow mesenchymal cell differentiation, cartilage cell, epidermal cell and the role of fibroblast proliferation, has obvious accelerating the bone tissue regeneration, peripheral nerve tissue regeneration and wound in particular ulcer wound healing, and the like. The composite porous molding material can be used for bone, tooth defect repair. Mode of execution Embodiment 1. (1), accurate weighing 1 g gelatin powder into a 100 ml beaker, add 4 ml deionized water, dissolving 10 minutes, the stirring and dissolving in water bath 60 ±1 °C, then added to the beaker to particle size in the nanometer 20 ±10nm β-tricalcium phosphate powder 0.2g, and then join the antler polypeptide 0.1g, stirring 20 minutes, obtaining the mixed slurry. (2), the rotational speed is 100 revolutions/minutes of stirring, the step (1) in the mixed slurry prepared by slow dropwise to 50 ml with surfactant (SPAN 80, 1g/20 ml) in the soybean oil, stirring to form a water-in-oil emulsion, the reaction temperature is maintained at 30 ±1 °C, and continue to stir 2 hours. (3), after the reaction is finished, the step (2) of the water-in-oil emulsion in the rapid shift-in to ice, and keep stirring, cooling 40 minutes, so that the containing nano-β-tricalcium phosphate gelatin gelation, the gelatin gel formed uniformly dispersed nano-β-tricalcium phosphate and antler polypeptide. (4), then, to the step (3) is added in the reaction system of the mass concentration is 8% of the glutaraldehyde cross-linking agent 600ul, cross-linking of the gelatin gel, stirring 30 minutes, the acetone is added to the system 10 ml, after cross-linking of the cross-linked gelatin gel material for dehydration, cessation of stirring, the slurry is filtered, the filter cake by the gelatin, calcium phosphate, polypeptide Pantotrichum crude block composite material; the thick article having the composite material 30 ml acetone washed repeatedly 3 time, freeze-drying, the final product obtained is a pale yellow by the gelatin, β-tricalcium phosphate, Pantotrichum powdery composite material of the polypeptide; (5), lactic acid takes gathers 2g dissolved in 12 ml of 1, 4-dioxane in, adding to step (4) the obtained powdery composite material 1g in, after mixing, the polytetrafluoroethylene in the mould of interpolymers, in -5 the frozen [...] 30 minutes, and after the freeze-drying, to obtain the required for bone repair composite porous molding material. The composite porous molding material is a polylactic acid as the frame, are uniformly dispersed in the framework of a cross-linked gelatin, β-tricalcium phosphate and antler polypeptide; and the surface of the porous structure of the, aperture is 300um -1 mm. The composite porous molding material used in the bone, the defective repair of the teeth. Embodiment 2. (1), accurate weighing 1 g gelatin powder into a 100 ml beaker, add 20 ml deionized water, dissolving 10 minutes, the stirring and dissolving in water bath 35 ±1 °C, then added to the particle size in a beaker 5-20 microns hydroxy apatite powder of 0.05g, then polypeptide to 3 mg, stirring 30 minutes, obtaining the mixed slurry. (2), the rotational speed is 6000 revolutions/minutes of stirring, the step (1) is slowly dripped into the mixed slurry dissolved with 100 ml with surfactant (SPAN 60-1g/200 ml) in the olive oil, stirring to form a water-in-oil emulsion, the reaction temperature is maintained at 70 ±1 °C, and continue to stir 2 hours. (3), after the reaction is finished, the step (2) of the water-in-oil emulsion in the rapid shift-in to ice, and keep stirring, cooling 40 minutes, the gelation of gelatin containing hydroxyapatite, formed uniformly dispersed in the gelatin gel micron hydroxyfluorapatite and antler polypeptide. (4), and then, to the step (3) adding acetone in the reaction system of 40 ml, is continuously stirred for 40 minutes, the gelatin gel material for dehydration, cessation of stirring, the slurry is filtered, the filter cake by the gelatin, hydroxy apatite, polypeptide Pantotrichum crude block composite material, the thick article having the composite material 30 ml acetone washed repeatedly 4 times, freeze-drying, the obtained final product white by the gelatin, micron hydroxyapatite, polypeptide Pantotrichum powdery composite material. (5), lactic acid takes gathers 1g dissolved in 3.3 ml methylene chloride, then adding to step (4) the obtained powdery composite material 1g in, after mixing, the polytetrafluoroethylene in the mould of interpolymers, in -5 the frozen [...] 30 minutes, after the freeze-drying, to obtain the necessary composite porous molding material. The composite porous molding material is a polylactic acid as a frame, the frame uniformly dispersed without cross-linking of the gelatin, hydroxy apatite and antler polypeptide; and the surface of the porous structure of the, aperture to 100um -300um. The composite porous molding material used in the bone, the defective repair of the teeth. Embodiment 3. (1), accurate weighing 1 g gelatin powder into a 100 ml beaker, add 5 ml deionized water, dissolving 10 minutes, the stirring and dissolving in water bath 50 ±1 °C, subsequently to the beaker, add weight ratio in the 1 [...] 1 of the calcium hydrogen phosphate and calcium carbonate compound calcium salt powder 4g, the particle size of the powder composite calcium salt to 30um left and right, and then add BMP-21mg, stirring 60 minutes, obtaining the mixed slurry. (2), the rotational speed is 200 revolutions/minutes of stirring, the step (1) in the mixed slurry made to slowly dropwise with 5 ml of surfactant (sodium dioctyl succinate (AOT)-1g/50 ml) in the tea, stir and form water-in-oil emulsion, the reaction temperature is maintained at 45 ±1 °C, and continue to stir 2 hours. (3), after the reaction is finished, the step (2) of the water-in-oil emulsion in the rapid shift-in to ice, and keep stirring, cooling 30 minutes, so that the containing composite calcium salt of the gelatin gelation, in forming the gelatin gel uniformly dispersed calcium hydrogen phosphate and calcium carbonate and BMP-2. (4), to the step (3) is added in the reaction system of the mass concentration is 4% formaldehyde 600ul cross-linked, stirring 20 minutes, adding acetone to the system 30 ml, of the cross-linked gelatin gel material after dehydration, cessation of stirring, the slurry is filtered, the filter cake by the gelatin, calcium hydrogen phosphate, calcium carbonate, BMP-2 block composite material of a crude product, crude article having the composite material 30 ml acetone washed repeatedly 3 time, freeze-drying, the final product obtained is a pale yellow by the gelatin, calcium hydrogen phosphate, calcium carbonate, BMP-2 of the powdery composite powder. (5), lactic acid takes gathers 1g dissolved in a 20 ml volume ratio of the 1 [...] 1 of in the mixed solvent of chloroform and acetone, is added to the step (4) preformed powdery composite material 1g in, after mixing, the polytetrafluoroethylene in the mould of interpolymers, in -5 the frozen [...] 30 minutes, after the freeze-drying, to obtain the necessary composite porous molding material. The composite porous molding material is a polylactic acid as the frame, are uniformly dispersed in the framework of a cross-linked gelatin, calcium hydrogen phosphate, calcium carbonate and BMP-2; and the surface of the porous structure of the, aperture is 300um -800um. The composite porous molding material used in the bone, the defective repair of the teeth. Embodiment 4. (1), accurate weighing 1 g gelatin powder into a 100 ml beaker, add 5 ml deionized water, dissolving 10 minutes, the stirring and dissolving in water bath 50 ±1 °C, subsequently to the beaker, add weight ratio in the 1 [...] 1 nanometer dicalcium phosphate and tetracalcium phosphate compound calcium salt powder of 0.4g, composite calcium salt powder particle size of about 300 nm -500 nm, then the adding BMP-73mg, stirring 30 minutes, obtaining the mixed slurry. (2), the rotational speed is 200 revolutions/minutes of stirring, the step (1) the mixed slurry slowly dripped into 250 ml with surfactant (SPAN 80-1g/50 ml) in blending oil, gelatin solution of a water-in-oil emulsion, the reaction temperature is maintained at 45 ±1 °C, and continue to stir 2 hours. (3), after the reaction is finished, the step (2) of the water-in-oil emulsion in the rapid shift-in to ice, and keep stirring, cooling 50 minutes, so that the containing composite calcium salt of the gelatin gelation, are uniformly dispersed in a gelatin gel there are two kinds of calcium phosphate compound calcium salt and BMP-7. (4), to the step (3) after cooling added to the reaction system of the mass concentration is 8% glutaraldehyde 600ul cross-linked, stirring 50 minutes, the acetone is added to the system 30 ml, of the cross-linked gelatin gel material after dehydration, cessation of stirring, the slurry is filtered, the filter cake by the gelatin, two kinds of calcium phosphate, BMP-7 block composite material of a crude product, crude article having the composite material 30 ml acetone washed repeatedly 3 time, freeze-drying, the final product obtained is a pale yellow by the gelatin, calcium hydrogen phosphate, tetracalcium phosphate, BMP-7 of the powdery composite material. (5), lactic acid takes gathers 1g is dissolved in 12 ml volume ratio of the 1 [...] 1 of in the mixed solvent of chloroform and acetone, and then add to step (4) preparation of the powder composite material 1g in, after mixing, the polytetrafluoroethylene in the mould of interpolymers, in -5 the frozen [...] 30 minutes, after the freeze-drying, to obtain the necessary composite porous molding material. The composite porous molding material is a polylactic acid as the frame, are uniformly dispersed in the framework of a cross-linked gelatin, calcium hydrogen phosphate, tetracalcium phosphate and BMP-7; and the surface of the porous structure of the, aperture is 200um -600um. The composite porous molding material used in the bone, the defective repair of the teeth. Embodiment 5. (1), accurate weighing 1 g gelatin powder into a 100 ml beaker, add 5 ml deionized water, dissolving 60 minutes, the stirring and dissolving in water bath 50 ±1 °C, subsequently to the beaker, add weight ratio in the 1 [...] 1 nanometer calcium hydrogen phosphate and calcium carbonate compound calcium salt powder of 0.6g, composite calcium salt powder having a particle size of 500 nm -1um, adding BMP-23mg then, stirring 30 minutes, obtaining the mixed slurry. (2), in the rotational speed to 2000 revolutions/minutes of stirring, the step (1) obtaining the mixed slurry slowly dropwise added to 200 ml with surfactant (SPAN 80-1g/50 ml) in the rape seed oil, stirring to form a water-in-oil emulsion, the reaction temperature is maintained at 45 ±1 °C, and continue to stir 2 hours. (3), after the reaction is finished, the step (2) of the water-in-oil emulsion in the rapid shift-in to ice, and keep stirring, cooling 60 minutes, so that the containing composite calcium salt of the gelatin gelation, form uniformly dispersed in the gelatin gel compound calcium salt and BMP-2. (4), to the step (4) after cooling added to the reaction system of the mass concentration is 8% formaldehyde 500ul cross-linked, stirring 60 minutes, the acetone is added to the system 25 ml, of the cross-linked gelatin gel material after dehydration, cessation of stirring, the slurry is filtered, the filter cake by the gelatin, calcium hydrogen phosphate, calcium carbonate, BMP-2 block composite material of a crude product, crude article having the composite material 30 ml acetone washed repeatedly 3 time, freeze-drying, the final product obtained is a pale yellow powdery composite material. (5), lactic acid takes gathers 0.05g dissolved in 12 ml volume ratio of the 1 [...] 1 of in the mixed solvent of chloroform and acetone, and then add to step (4) the obtained powdery composite material 1g in, after mixing, the polytetrafluoroethylene in the mould of interpolymers, in -20 the frozen [...] 30 min, after the freeze-drying, obtain the desired composite porous molding material. The composite porous molding material is a polylactic acid as the frame, are uniformly dispersed in the framework of a cross-linked gelatin, calcium hydrogen phosphate, calcium carbonate and BMP-2; and the surface of the porous structure of the, aperture is 500um -1 mm. The composite porous molding material used in the bone, the defective repair of the teeth. The invention belongs to the field of the preparation of a gelatin derivant material and particularly relates to a composite porous forming material for bone restoration, a preparation method and the application of the composite material. The composite porous forming material adopts polylactic acid as a supporting frame in which cross-linked or non-cross-linked gelatin, calcium phosphate and an active substance (cartialgenous polypeptide or BMP) capable of promoting bone growth are uniformly dispersed, wherein the weight of the active substance (the cartialgenous polypeptide or the BMP) is 1 per thousand to 10 per hundred of that of the gelatin, the weight ratio between the calcium phosphate and the gelatin is 1:20 to 4:1, and the weight ratio between the polylactic acid and the gelatin is 1:20 to 2:1. A cell experiment and an animal experiment show that the composite porous forming material for the bone restoration is a bone restoration embedding material that has good biocompatibility and can induce the bone forming activity. 1. A composite used for repairing bone porous molding material, which is characterized in that: the composite porous molding material is a polylactic acid as a support frame, the frame uniformly dispersed in gelatin, calcium phosphate and antler polypeptide or bone morphogenetic protein; wherein antler polypeptide or bone morphogenetic protein is gelatin weight of the 1 [...] -10% ; calcium phosphate with gelatin the weight ratio of the 1 [...] the 20-4 [...] 1, poly-lactic acid and gelatin the weight ratio of the 1 [...] the 20-2 [...] 1. 2. For bone repair composite porous molding material according to Claim 1, which is characterized in that: the gelatin is dispersed in the framework without cross-linked gelatin or after cross-linking agent cross-linking of the cross-linked gelatin. 3. For bone repair according to Claim 2 the composite porous molding material, which is characterized in that: the cross-linking agent is selected from glutaraldehyde, formaldehyde, dialdehyde glucose, genipin or a mixture of more than more than one; the amount of cross-linking agent in the reaction the addition of cross-linking agent, which is added per gram of gelatin 30u1-1000ul cross-linking agent, cross-linking agent for the mass concentration of the 5 [...] -15%. 4. For bone repair composite porous molding material according to Claim 1, which is characterized in that: said calcium phosphate particle size in the range of 10 nm -1 mm. 5. For bone repair composite porous molding material as in Claim 1 or Claim 4, which is characterized in that: said calcium phosphate selected from hydroxyapatite, tricalcium phosphate, calcium pyrophosphate , calcium biphosphate, calcium phosphate, tricalcium phosphate, calcium carbonate or a mixture of more than more than one kind. 6. For bone repair composite porous molding material according to Claim 1, which is characterized in that: the composite used for repairing bone of the porous molding material on the diameter of the hole 10 nm -1 mm. 7. A gas 6 to any one of the composite used for repairing bone preparation method of the porous molding material according to Claim 1, characterized in that the method comprises the following steps: 1) heating gelatin powder, adding deionized water soluble expansion, and postheating to 35-70 the formed gelatin solution [...] , then added to the gelatin solution of calcium phosphate, calcium phosphate and calcium phosphate addition is the weight ratio of the 1 [...] the 20-4 [...] 1 ; subsequently, adding antler polypeptide or bone morphogenetic protein, antler polypeptide or bone morphogenetic protein to the addition of the weight of the 1 [...] -10% ; stirring 20-60 minutes, to obtain a multi-component mixed slurry; 2) step 1) is poured into the mixed slurry prepared by dissolving a surface active agent in the oil, stirring to form a water-in-oil emulsion; surface active agent content is in the oil of the oil -1g/20 ml 1g/200 ml oil; the amount of oil used per gram of gelatin 5 ml -250 ml; 3) step 2) water-in-oil emulsion prepared by heating, temperature control in the 35-70 the [...][...] , and continuously stirring, the stirring speed is 100 rpm/minute -6000 revolutions per minute; 4) under agitation, the steps 3) the obtained water-in-oil emulsion used for cooling ice; under the ice, gelatin gelation, are uniformly dispersed in the gelatin gel with calcium phosphate and antler polypeptide or bone morphogenetic protein; 5) to the cooling step after 4) in the reaction system by adding acetone or ethanol, acetone or ethanol is oil-in-water-in-oil emulsion in the volume of the moisture content 2-8 times, continuing to stir, filtering, consisting of gelatin, calcium phosphate, antler polypeptide or bone morphogenetic protein of crude bulk composite material; 6) step 5) the obtained composite material coarse article after repeated washing acetone, freeze-drying, consisting of gelatin, calcium phosphate, antler polypeptide or bone morphogenetic protein of the powdery composite material; 7) in step 6) the obtained powdery composite material of poly lactic acid solution is added, mix, wherein the polylactic acid with gelatin the weight ratio of the 1 [...] the 20-2 [...] 1; 8) step 7) mixing the homogeneous product fill the die, after the forming of the film to the material, and then in-5--20 the frozen [...] , by freeze drying, be used for repairing bone composite porous molding material. 8. Method according to Claim 7, which is characterized in that: the cooling step after the 4) in the reaction system before adding acetone or ethanol, add cross-linking agent, cross-linking agent for the mass concentration of the 5 [...] -15%, the amount of cross-linking agent per gram of gelatin added 30ul -1000ul cross-linking agent. 9. Method according to Claim 7, which is characterized in that: said surface active agent is a SPAN series surface active agent or dioctyl sodium sulfosuccinate a surfactant; the oil is selected from the group consisting of silicone oil, soybean oil, olive oil, camellia oil, rapeseed oil or a mixed oil. 10. A any one of the composite used for repairing bone the application of the porous molding material according to Claim 1-6, which is characterized in that: the composite used for repairing bone porous molding material can be used as a bone, the material of the dental restoration.