PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ANTICANCER AGENT-INDUCED HEMATOPOIETIC TOXICITY, COMPRISING CIBOTIUM BAROMETZ J. SMITH EXTRACT AS ACTIVE INGREDIENT AND HEALTH FUNCTIONAL FOOD
The present invention refers to opening chuck ( American as well as our arm, Japanese on 1-2 cause death even if it is subjected to large hospital mortality in particular which rivals for occupies lowers a clock signal to or more (life science trends, bio-technology Institute, 3:55,1995 ; crane, [...], cancer chemical therapy, antifogging suffused with the pale light, 351,1991). Generally treatment for such cancer surgery, radiation therapy, chemotherapy most are utilised. Flow into an anticancer as at chemical therapy associated life science kernels most research in technology development is formed, various kinds of cancer cells using but an attempt is many, to date the meanings true a not anticancer as therapeutic agents any a co-therapeutic agent both the areas of such a magnitude that induces help complete recovery in a short life extending without the medicament is developed outside. Furthermore, radiation therapy as chronic administration toxicity and the chemotherapy patient quality of life of a situation where it is conceivable that the problem the operator which, current the treatment of normal cells and cancer cell selectively existence of a the treatment with the. do not. Radiation therapy or chemical therapy selectively functions to cancer cells rather than normal cells, the appointed cell division in particular bone marrow tissue, gastrointestinal mucosal tissues or the like since the damaging, cover the most probable as chronic administration bone marrow hematopoietic disorders, gastrointestinal disorders, . causing adverse effects and such as alopecia. Adverse side-effects of radiation chemotherapy, the reduce the method control cancer medicine-of-interest in the field of medicine 2ew would be increased to thereby actively the treatment of resulting from an association studied of wet liquid to flow down. The, licorice extract (doxorubicin) doxorubicin as an anticancer agent are infected to is induced by cardiovascular toxicity (cardiotoxicity) mitigate (Choi HJ, Furthermore, they, in call patent 10-0697212 registration 25th which -85.0% %, radix astragali and alba, angelicae gigantis radix mixed herb extract which contain as the active ingredient, induced by the administration anticancer hematopoietic for the treatment of side effects which an agent for accelerating the disclosure, in call patent 10-1398076 registration 25th which egg or soy isolated from a phsophole [...] including as active ingredient of the above composition for to be a disclosure, cisplatin in call patent 10-0501039 registration 25th which kidney toxicity of the sparingly (cisplatin), hematopoietic immune toxicity, fire extinguisher ( However, various mechanisms for anticancer caused by a hematopoietic for toxicity, has excellent inhibition to show inhibitory effect on simultaneously low woman associated and treating since no reported unmounted, control channel and searches for such drug candidate for improving side effects of an anti-cancer treatment for use as composition for all of the studies of. desired in which the container has such continues. Barometz is provided for preventing or delaying opening chuck ( The, the present inventor are induced by anticancer from the existing ways to infuse of hematopoietic toxicity remedies for for developing effort results, (Paclitaxel) paclitaxel extract of heat shrinkage of chuck opening, irinotecan (Irinotecan), doxorubicin (Doxorubicin) mechanisms for of a polyimide resin, such induced by anticancer hematopoietic toxicity common for alleviating or curing has at least as well as, the native having anticancer agent-or that the attenuated for efficacy not enhance growth of the cancer, hematopoietic hot extract of chuck opening said for prevention and treatment of of toxicity as active ingredient of pharmaceutical composition to be used by identifying, the present invention, is completed. The present purpose of the invention the, that the attenuated for efficacy of anticancer or without enhance growth of the cancer, induced by anticancer simultaneously provide a toxicity and hematogenous reduce the heat-toxicity, hematopoietic induction anticancer for prevention and treatment of of toxicity by a rope. provides pharmaceutical compositions. The for achieving a the aim said, the present invention refers to opening chuck ( Furthermore, useful as anti-chuck opening the present invention refers to hematopoietic containing health food for prevention and improvement of of toxicity provides. Extract chuck opening of the present invention different mechanisms for various anti-cancer drugs or that the attenuated for efficacy of without promoting growth of cancer cells, induced by anticancer simultaneously provide a toxicity so that effectively moderated toxicity and hematogenous, hematopoietic induction the extract chuck opening said for prevention and treatment of of toxicity enables an advantageous active ingredient of pharmaceutical composition can be used. Figure 1 shows a also various anti-cancer drugs parent hematopoietic cellulose in a broth medium processing cell survival of cells is the mobile phone confirms the degree. Also Figure 2 shows a hot-water extract chuck opening mixtures of varying concentrations is bone marrow cells proliferation is the mobile phone confirms the effect displayed in a liquid. A peptide which specifically binds to hot-water extract chuck opening Figure 3 of hematopoietic cultured colony group exhibits and parent of cells (colony). Figure 4 shows a chuck opening also extract of bone marrow cells by anticancer to the mitigating growth inhibition is a supervis ion portion confirms a. Figure 5 shows a hot-water extract chuck opening also the anticancer processing tumoral cells is be achieved, wherein an influence on anticancer activity is confirming the receivable channel. Hereinafter, the defined terms of the present invention. Terms used in the present invention "hematopoietic toxicity" hematopoietic dysfunction, in particular hematopoietic disorder or red blood or immune system cells, the pocket P-dysfunction leukocyte e.g., hematopoietic system for or cell endotracheal. to a peer. Preferably, bone marrow in hematopoietic or immune system function affected by hematopoietic toxicity. Therefore, said hematopoietic toxicity is generally bone marrow toxicity, including for neutropenia and anemia is preferably, specifically chemical compounds or drug or by the administration of such dosing as a result of. and it is more preferred to set. In the present invention, said chemical compounds or drug anticancer agents is preferably not less. Hereinafter, the described specifically for the present invention. The present invention refers to, opening chuck ( Said water extract, C1 to C2 lower alcohols or mixtures thereof are as solvent it is preferable that the product economically since the reaction is carried, the ethanolamine said lower alcohols is preferably not less or methanol. Said opening chuck extract by including manufacturing method of the following steps is preferably made, but not limited to: 1) opening chuck vehicle speed is lower than the extracted by the application of extraction solvent; 2) step 1) extract of filtration step; and 3) step 2) of filtering the extract after drying, concentrating it under reduced pressure. In said method, step 1) of culturing chuck or commercially available, use can be made of, and without restriction, such as. Opening said get gold wool nine ship chuck is preferably not less. In said method, method for extraction of chuck opening at filtering method, reduces blood cholesterol, platelet, immersion extraction, such as extracting ultrasonic extraction and cooling reflux conventional homogeneously distributed can be using method. Said amount of chuck roaster in dryness of the extraction solvent 20 to 2 added back it is preferable that the product economically since the reaction is carried. Extraction temperature is preferably 20 to 50 °C but not limited to. Furthermore, the extraction time 100 to 10 is preferably in an time, specifically preferably 24 to 96 thereby, more particularly 72 time most preferably, but not limited to. In said method, step 3) of a vacuum condensing with decompressing decompression thickener or vacuum rotary twin is preferably conducted by, but not limited to. Furthermore, the drying reduced pressure drying, vacuum drying, boiling drying, spray dry or lyophilized is preferably, but not limited to. In said method, step 3) of a vacuum condensing with decompressing decompression thickener or vacuum rotary twin is preferably conducted by, but not limited to. Furthermore, the drying reduced pressure drying, vacuum drying, boiling drying, spray dry or lyophilized is preferably, but not limited to. Said hematopoietic toxicity induced by anticancer it is preferred to set a, said (antitumor antibiotics) antitumor antibiotic anticancer, phase rational nitrification enzyme number (topoisomerase inhibitor) inhibitors, or taxane (taxane) based drug, including, but not limited to clinical which, pharmaceutical, biomedical used therapeutically as well as all food contains a compound represented by the.. An Azithromycin misfortune mote Roh E a antitumor antibiotic said D (actinomycin D), (bleomycin sulfate) sulfate erythromycin [...], daunomycin (daunomycin), dowel deer rain shoes (daunorubicin), doxorubicin (doxorubicin), doxorubicin epitaxial (epirubicin), doxorubicin (idarubicin) costume, mitogenic (mitomycin) erythromycin, erythromycin mitt and C (mitomycin-C)-erythromycin mitogenic (mitramycin) selected from the group consisting of is preferably in an more than one, more preferably doxorubicin specifically but, not limited to. Said phase rational nitrification enzyme inhibitors irinotecan (irinotecan), camping camptothecin (camptothecin), norbornene (novobiocin) biot new, doxorubicin epitaxial (epirubicin), an Azithromycin [...] (dactinomycin), (amsacrine) clean cancerous company, [...] (etoposide) etoposide and (teniposide) selected from the group consisting of is preferably in an more than one, specifically irinotecan or it is more preferred to set a it is reel unit, not limited to. Said taxane based the drug is an paclitaxel (paclitaxel) or docetaxel (docetaxel) is dynes either or both is preferably in an, or it is more preferred to set a [...] specifically, not limited to. In specific embodiment of the present invention, the present inventor are part of the various anti-cancer drugs result confirming the receivable channel toxicity hematopoietic the gradation indicated by the video data, various mechanisms for anticancer a toxicity hematopoietic sequentially it has been confirmed (also reference 1). Furthermore, the present inventor for producing heat chuck opening are myelodysplastic cell proliferation which indicates to effect the mobile phone confirms the result, when opening chuck heat extract and hematopoietic parent of cells (colony) group colony and a tendency to increase, is a bulked size of it has been confirmed (also 2 and 3 reference). Furthermore, the present inventor by anticancer extract chuck opening are of bone marrow cells to the mitigating growth inhibition results supervis ion portion confirms a, bone marrow toxicity caused at a concentration in compound represented by the chuck opening in one instance processing hot-water extract of cells parent hematopoietic by verify increased significantly colony army corresponding advertisement based on the shown list (also 4 reference), anticancer agents hot-water extract chuck opening, by using a time hopping code for processing to cancer cells or that the attenuated for efficacy of anticancer that does not promote growth of cancer cells it has been confirmed (also 5 reference). Therefore, opening of the present invention different extract chuck mechanisms for various anti-cancer drugs or that the attenuated for efficacy of without promoting growth of cancer cells, induced by anticancer simultaneously provide a toxicity so that effectively moderated toxicity and hematogenous, hematopoietic induction the extract chuck opening said for prevention and treatment of of toxicity enables an advantageous active ingredient of pharmaceutical composition can be used. Of the present invention composition is an oral or parenteral a variety of formulations can be. When the formulated composition said common filling number, number extender, coupled number, wetting, disintegrating, or of a thinning agent surfactant is formulated excipient. Solid medicinal preparation is finished, the perfume ingredient for oral administration, bolus, masked powders that are to be, granules number, capsule number including an, such solid formulation contains at least one compound at least one or more excipients number for example, starch, calcium carbonate, sucrose (sucrose) or lactose (lactose), is prepared of gelatin. Furthermore, simple number magnesium stearic acid in addition to excipients, such as talc is used lubricants provide. Liquid formulations for parenteral administration include suspension number, content liquid, emulsion or syrup number which, including, the additive and water as the diluent a simple commonly used, in addition to paraffin a bioliquid number various excipient, for example wetting, sweetener, fragrance or a and preservatives may include. Agents are for parenteral administration in the sterilized aqueous solution, non-aqueous solvent, solvent suspension, emulsion, comprises such as a suppository or freeze-dried preparation. Non-aqueous solvent and a suspension solvent include propylene glycol (propylene glycol), polyethylene glycol, vegetable oil olive, such as an oil, ethyl [...] the scanning electrode and the ester can be or the like is used as an. [...] include base left proposal (witepsol), macrogol glyceride, twin (tween) 61, carcass five fingers, does comprising lauric acid, glycerol, gelatin can be or the like is used as an. Of the present invention composition is an oral or parenterally can be administered, , either intraperitoneally or external the skin upon parenteral administration, rectal, intravenous, muscle, avoid, intrauterine epidural or cerebrovascular injection it is preferable that the scheme corresponds to, most preferably employs skin external. Effective compositions comprise pharmaceutical of the present invention the administered in an amount. In the present invention, "in a pharmaceutically effective amount and a" applicable to medical treatment through a rational will benefit/risk ratio a unit, device and method to a sufficient amount meaning, effective capacity type of diseases, a patient level, in the severity, drug action, sensitivity to drugs, administration time, route, and discharge ratio, therapy period, the inhaler includes a mechanism to open signal by using an elements and other medical well-known to the field can be determined according to factors. Useful when administered therapeutic agent individual composition of the present invention or with additional therapeutic agents administered of the existing method can be sequential or from therapeutic agent can be administered simultaneously, can be single or multiple administration. Considers both the components least side effect without a starting switch enables the maximum amount of administration of a amount are important, by the one skilled in the art can be the storing apparatus. Dosage is the body mass of the subject of the present invention composition, age, sex, health status, dietary, administration time, administration method, the flexible bumper structure for severe and/or prevention of diseases and rate disposed, saccharin natrium, the range, daily dose constitutes a opening chuck extract based on the amount of polyvinylarene, and 0.01 to 1000 mg/kg, preferably 30 to 500 mg/kg and, more preferably is 50 to 300 mg/kg, 1-6 day can be administered once. However route, , the severity of obesity, sex, weight, age and the like increase/decrease can be said even any method with a dosage of the present invention. are not limited to range. Of the present invention composition is preferably chemical therapies method as the combined use of a together with anticancer agent but is preferably, alone, or surgical, radiation therapy, hormonal therapy, and biological response modifiers are using conjunction with method, use can be made of,. Furthermore, useful as anti-chuck opening the present invention refers to hematopoietic containing health food for prevention and improvement of of toxicity provides. Said extract water, ethanol or mixtures thereof the as solvent are wind pattern includes a plurality. Said hematopoietic toxicity induced by anticancer it is preferred to set a, said antitumor antibiotic anticancer, phase rational nitrification enzyme inhibitors number or taxane-based drug, including, but not limited to clinical which, pharmaceutical, biomedical used therapeutically as well as all food contains a compound represented by the.. Extract chuck opening of the present invention different mechanisms for various anti-cancer drugs or that the attenuated for efficacy of without promoting growth of cancer cells, induced by anticancer simultaneously provide a toxicity so that effectively moderated toxicity and hematogenous, hematopoietic induction the extract chuck opening said for prevention and improvement of of toxicity enables an advantageous an effective ingredient of health food can be used. In the present invention, "health food" meal daily rotation ultraviolet beam, that is easily deficient in nutrient or corn syrup, rice bran, or components raw material having function of (functional) to prepared using the thermoforming method, normal human physiology or maintaining the functions of an through the activation the maintenance of a healthy body bureau chief the food food and improved safety pharmaceuticals but means is defined, which not limited to the conventional post-treatment system is used the widest sense of including both. With specific type of food said't limitation. With addition of said examples of food abundant, meat, sausage, bread, biscuits, rice cake, chocolate, candy current, snack food holding magazines, confectionery, pizza, ramyon, other noodles, gum type, ice cream containing a dairy product, various sprocket, beverage, alcoholic drinks and vitamin complex, milk product and reacts with polishing solution articles, or the like is, in the conventional health food includes both. Said purified health food, capsule, powder, granules, liquid, for example, in such a form ring manufacturing, can be processed but, not limited to manufacturing with some aspects according to law which, method is supplied. Opening of the present invention to be laid on the food extract chuck, and for preparing foods or food other it has been deposited by either adding can be used along with at, conventional method suitably according to can be used. The amount of active ingredient mixing a use purpose thereof according to (for treatment or prevention) can be determined for. Generally, the total amount of a compound of the subject said food health food 90 to 0.1%, by weight of the water can be is forced parts by weight. However health and sanitary pad intended to a long is intended to control health or in the case of ingestion of the amount said range may be said hereinafter, with a fixing member of the back in the aspect of safety because of the absence of containing, as the active ingredient, an amount of at least said range can be used. Functional health of the present invention set in a ratio indicating beverage composition which comprises, as essential ingredients, said other ingredients except that the containing the compounds with specific are restrictions such as drinks and conventional free various flavor furthermore, the number of carbohydrate or natural number can be as a component. Waste transfer crane of nuclear power mono examples of the above-mentioned natural carbohydrate, for example, glucose, such as oligosaccharides; disaccharides, for example maltose, sucrose such as; and polysaccharide, for example dextrin, cyclodextrin and the like is conventional processing modules, such as sugar, and xylitol, sorbitol, erythro [...] is intraorally rapidly disintegrable such as. The above-mentioned other than natural flavor number number flavor (TAU Martin, Stevia extract (for example [...] A, [...] ) and synthetic flavor number (saccharin, such as [...] ), use can be made of, advantageously. The ratio of carbohydrate natural said 100 composition of the present invention per generally about 1 to 20 g, preferably about 5 to 12 g is. In addition to said chuck opening of the present invention in relation to a variety of nutritional number extract, vitamin, mineral (electrolyte), synthetic flavor number and natural flavor number flavor such as number, colored prominent figure and number (cheese, such as chocolate) number, [...] and salts thereof, alginate and salts thereof, organic acid, protective colloidal thickener, pH modulators, stabilizer, preservative, glycerin, alcohol, such as agent carbonate used carbonated beverage can. Chuck opening of the present invention while allowed to be juice beverages and and fruit fruit juice useful for the production of vegetable beverage can matrix shape. These components independently, use can be made of, or in combination, or in combination. So the ratio of these additives that it will not important but per 100 parts by weight of the present invention opening chuck extract 0.1 to about 20 parts by weight of which is selected from the range of is it is generally designated on a. Hereinafter, in the embodiment of the present invention, as further described and/or at least two different and manufacturing e.g. experiment.. Stage, in the embodiment a, and manufacturing e.g. experiment examples of the present invention relate a is, in the embodiment a contents of the present invention, and manufacturing e.g. experiment and/or at least two different limited not. < 실시예 1>Opening chuck ( <1-1>Opening chuck heatof processing for extracts of To perform thereby, the cold air flows experiment of the present invention, been produced with at hot extract of chuck opening. Specifically, carbonate and, and drying the chuck opening, heat extraction of extract heat chuck opening concentrated under the reduced pressure and are obtained. <1-2>Methanol of processing for extracts of opening chuck Carbonate and, and drying the chuck opening, 99.9% methanol extraction of methanol extract chuck opening concentrated under the reduced pressure and are obtained. < 실험예 1>Various anti-cancer drugs of hematopoietic parent upon a cell identification of cytotoxic Part of the various anti-cancer drugs the gradation indicated by the video data to make sure that hematopoietic toxicity, cellulose in a broth medium processing compound represented by the hematopoietic parent cell survival degree identified. Specifically, mouse (myelocyte) bone marrow cells from a femur (femur) separated the. Furthermore, recombinant stem cells factor derived from RAT (recombinant murine stem cell factor, rm stem cell factor), rm IL-3, IL-6 recombinant of human origin (recombinant human IL-6, rh IL-6) for (rh Erythropoietin) erythropoietin rh and matter medium including [...] GF M3434 (methocult GF M3434) [table 1] a compound represented by the adding each, between said separating 7 bone marrow cells while culturing hematopoietic parent cell growth induced. After 7, obtaining a parent cells of hematopoietic growth, colony forming unit analysis (Colony Formin Unit assay, CFU assay) the anticancer agent-hematopoietic parent cell growth and differentiation be achieved, wherein an influence on has been observed on. As a result, as seen from in Figure 1 paclitaxel (Paclitaxel), irinotecan (Irinotecan), doxorubicin (Doxorubicin) anticancer mechanisms for of a polyimide resin, such sequentially hematopoietic toxicity a it has been confirmed (also 1). < 실험예 2>An intramedullary nail opening chuck hot-water extractidentification of promoting effect and cell proliferation Opening chuck hot-water extract is bone marrow cells proliferation skin tones in order to identify a with the time switch part, opening chuck heat extract and in a medium for culturing cells and has been observed on same. Specifically, separated the bone marrow cells from a femur mouse. Furthermore, rm stem cell factor, rm IL-3, including erythropoietin is rh and rh IL-6 [...] GF M3434 the culture medium to which, < 실시예 1>produced in said roaster chuck heat extract at a concentration of 25,50 or 100 micro g/Ml adding each, between said separating 7 bone marrow cells while culturing hematopoietic parent cell growth induced. After 7, the obtaining cells parent of hematopoietic growth, CFU analyzer analyze a spectrum and a phase of hematopoietic stem cells growth has been confirmed. Voice the control group at, opening chuck hot-water extract is handled as the solvent water (vehicle) and instead the same method is performed for all the. As a result, as seen from in Figure 3 and also 2, at various concentrations to mouse bone marrow cells of when extract and heat chuck, 25 micro g/Ml concentration in is disclosed a tendency to increase, is slightly of hematopoietic parent cells corresponding advertisement based on the shown list (also 2) it is confirmed that, generated CFU size of proportion to the concentration is also coupled to the processing device has been observed on an increase in (also 3). < 실험예 3>Useful for treatment of cancer induced bone marrow toxicity confirming mitigating effects of hot-water extractchuck old Opening chuck extract of bone marrow cells by anticancer to the mitigating growth inhibition to supervis ion portion confirms a, mouse bone marrow cells to bone marrow toxicity caused a certain degree of concentration of mixtures of varying concentrations together with anticancer agent opening chuck was filtered extract heat. Specifically, said < 실험예 2>configuration identical to the paclitaxel of including GF M3434 the culture medium to which 50 nm, 100 nm of 10 µm ruby shoes after toxin of irinotecan or, separated from a femur mouse bone marrow cells during culturing 7 parent hematopoietic while components that are useful for actively inducing cell growth, hematopoietic analyzer analyze a spectrum and a phase CFU parent cell growth has been confirmed. Voice the control group at, opening in a medium to not food contains a compound represented by the hot-water extract chuck and is handled as the solvent water (vehicle) instead the same method is performed for all the. As a result, opening chuck in Figure 4 as seen from the extract and when seed growth of of hematopoietic stem cells, generated colony group of hematopoietic parent of cells (colony) is statistically results in a significant increase that the phenomenon that the through that it exhibits, before action of anticancer extract chuck opening independently of marrow safening effect has been confirmed (also 4). < 실험예 4>Hot-water extractchuck opening may be achieved, wherein an influence effectiveness of anticancer agents in confirming An intramedullary nail anticancer is hot-water extract toxicity opening chuck to the mitigating an FIC it, that the attenuated for efficacy of anticancer in administration anticancer or cancer since the must not enhance growth of the, opening chuck hot-water extract is cancer, activity may be achieved, wherein an influence has been confirmed. Specifically, a cell line A549 lung of human origin as the United States code cell line bank (American Type Culture Collection, ATCC; unique number: CLL-185) purchased from the, 96-well plate to 5×103 l micro 100 cancer cells of suitable culture medium after frequency divides the together, 24 time 5% CO2 of humidification of good in incubator (humidified incubator). Culture nor post-incubation, 5, 10, 25, 50 or 100, are added to the culture medium for said micro g/Ml, paclitaxel of 50 nm as anticancer agents, paclitaxel of 100 nm, 10 µm of irinotecan, irinotecan of 50 µm, toxin of 500 nm doxorubicin or treating with ruby shoes toxin of 1 µm, good additional time 48. 48 process has been completed, by etching are removed and then culture medium, 100 micro l of 3 - (4,5-aminothiazole dimethyl-2-one) - 5 - (4-sulfoalkyl phenyl) - 2 - (3- [...] ) - 2H-thiazolium salt (MTS, 3 - (4,5-dimethylthiazol-2-yl) - 5- (3-carboxymethoxyphenyl) -2- (4-sulfophenyl) -2H-tetrazolium salt) solution by the addition of 3 to 1 after a time, it was determined that in 490 nm absorbance. Voice the control group at, anticancer form combined chuck extract said method in a medium without adding both the same method the culture a A549 cells the consumer selects a desired object, voice the control group of value with a reference and measuring absorbance, is odd growth relative to the long since determined the (relative proliferation index). Positive the control group without adding extract chuck opening at, only processes anticancer the same said method in culture media, in the stage of cell culture was A549 in method. As a result, as seen from in Figure 5, both a medium processing compound represented by the survival of cancer cells in a corresponding advertisement based on the shown list verify is reduced, this reduction regardless the existence and non-existence of processing extract chuck a shown, opening chuck hot-water extract is not for inhibiting the activity of cancer, it has been confirmed (also 5). < 제조예 1>For the production of a pharmaceutical preparation <1-1>it buys proposal manufacturing Extract chuck opening of the present invention 0.1 g Lactose- 1.5 g Talc 0.5 g Said mixing components in and welded into an airtight foil it buys sacrifice been produced with at, followed by filling the gap. <1-2>Preparation of tablets Extract chuck opening of the present invention 0.1 g Lactose 7.9 g Crystalline cellulose 1.5 g Magnesium stearate 0.5 g After mixing components in said purified position the other law (direct tableting method) have been prepared. <1-3>Of preparing an Extract chuck opening of the present invention 0.1 g Maize starch 5 g Carboxylic cellulose 4.9 g Mixing components in said time of a steam heater and then causing the powder to, said powder of capsule agent packed with an adsorbent to a hard capsule manufacturing method according to have been prepared are also sealed. <1-4>Production of injection solution Extract chuck opening of the present invention 0.1 g Distilled water sterilization for injection Dosage PH modulators Dosage Conventional of injection solution per ampoule 1 according to manufacturing method of (2 ml) said component content out. <1-5>Manufacturing Extract chuck opening of the present invention 0.1 g Isomerization per 10 g Mannitol 5 g Purified water Dosage Conventional of emusion type-manufacturing method according to each component water purified liquid dissolving the applied, then by applying a vegetable lemon direction said components is mixed. Then the entire applied recombinant collagen is adjusted in the range of 100 after the sterilization are potted bottle brown been produced with at be thus inhibited from decreasing. < 제조예 2>, Low fat and low cholesterol food <2-1>Flour food product has excellent 0.5-5.0 extract chuck opening of the present invention, are added to the taste parts by weight, using a mixture mixed the same bread, cake, cookie, a cracker and noodles have been prepared. <2-2>Sprocket and broth (gravies) for manufacturing 0.1-5.0 parts by weight of extract chuck opening of the present invention added to broth and sprocket in meat products promoting physical health, manufacturing processes and the cost of production broth and soup for noodles. <2-3>Ground beeps (ground beef) for manufacturing Extract chuck opening of the present invention added to 10 parts by weight of ground beeps been produced with at beeps ground promoting physical health. <2-4>Dairy (dairy products) for manufacturing 5-10 parts by weight of extract chuck opening of the present invention, are added to the milk, said milk using various manufacturing ice cream and butter and shortening been produced with at dairy. <2-5>Wire for manufacturing Brown rice, barley, glutinous rice, COiX seed and is dried alpha in a publicly known method of the if the particle size distribution after 60 mesh powder which have been prepared. Black soy beans, black sesame and, perilla also publicly known method of the if the dried and float in which 60 mesh particle size distribution after been produced with powder. To vacuum concentration extract chuck opening of the present invention reduced in pressure by the concentrated within, spray, flow type hot air dryer to dry particle size which a building is obtained is pulverized with mesh 60 dry powder is obtained. Said alcohol to the glycolide monomer at cereal, bell room and, to extract chuck opening of the present invention in the weight ratio of increasing a characteristic of emitting electrons by. Cereal (brown rice 30 parts by weight, COiX seed and 15 parts by weight, barley 20 parts by weight), bell room current (perilla 7 parts by weight, black soy beans 8 parts by weight, black sesame and 7 parts by weight), Extract chuck opening of the present invention (3 parts by weight), Ganoderma lucidum (0.5 parts by weight), hwang (0.5 parts by weight) <2-6>Of healthy food Extract chuck opening of the present invention 100 mg Vitamin mixtures dosage Vitamin A acetate 70 micro g Vitamin E 1.0 mg Vitamin B1 0.13 mg Vitamin B2 0.15 mg Vitamin B6 0.5 mg Vitamin B12 0.2 micro g C 10 mg vitamin Biotin 10 micro g 1.7 mg a nicotinic amide Folic acid 50 micro g Pantothenic acid calcium 0.5 mg Inorganic mixture dosage Sulfate 1.75 mg iron number 1 0.82 mg zinc oxide 25.3 mg magnesium carbonate Number 1 15 mg potassium phosphate Number 2 55 mg calcium phosphate 90 mg potassium citric acid 100 mg calcium carbonate 24.8 mg magnesium chloride Said relatively ratio composition of mixtures vitamins and minerals of health food components but hearts mixing to exemplify a preferred embodiment, modified optionally ratio blends which a non-intrusive may embodiment, conventional health food according to manufacturing method of said then combining a, and for making the granules, health food composition according to conventional method can be used to produce.. < 제조예 3>Manufacturing for healthy drink Extract chuck opening of the present invention 100 mg Citric acid 100 mg Oligosaccharide 100 mg Plum concentrate 2 mg 100 mg taurine The entire applied water 500 ml According to conventional health drink manufacturing method of said then combining a, about 1 should be heated to reach a stirring 85 °C time, made in the sterilized to filter out solution obtained container 1 ℓ rehrigeration custody in hermetically sealing sterilization then the. use in the production health drink composition of the present invention. Symbol relatively composition, said beverage components but hearts mixing to exemplify a preferred embodiment, layer demand, demand country, using local uses and the like, according to preference in people modified optionally ratio blends. a non-intrusive may embodiment. The present invention relates to a pharmaceutical composition for preventing and treating hematopoietic toxicity, comprising a Cibotium barometz J. Smith extract as an active ingredient. More specifically, the Cibotium barometz J. Smith extract of the present invention prevents the effects of various anticancer agents having mechanisms different from each other or prevents the promotion of the growth of cancer cells, and effectively alleviates the hematopoietic toxicity and bone marrow toxicity induced by the anticancer agents. The Cibotium barometz J. Smith extract can be efficiently used as an active ingredient of the pharmaceutical composition for preventing and treating the anticancer agent-induced hematopoietic toxicity. COPYRIGHT KIPO 2016 Opening chuck ( According to Claim 1, said water extract, C1 to C4 lower alcohols or mixtures thereof are as solvent extraction of the hematopoietic characterized by pharmaceutical composition for treating and prevention of toxicity. According to Claim 2, said lower alcohols the ethanolamine or methanol is hematopoietic characterized by pharmaceutical composition for treating and prevention of toxicity. According to Claim 1, said hematopoietic toxicity induced by anticancer agents to hematopoietic characterized by pharmaceutical composition for treating and prevention of toxicity. According to Claim 4, said (antitumor antibiotics) antitumor antibiotic anticancer, phase rational nitrification enzyme number (topoisomerase inhibitor) inhibitors, is drug-based (taxane) taxane or hematopoietic characterized by pharmaceutical composition for treating and prevention of toxicity. According to Claim 5, an Azithromycin misfortune mote Roh E a antitumor antibiotic said D (actinomycin D), (bleomycin sulfate) sulfate erythromycin [...], daunomycin (daunomycin), dowel deer rain shoes (daunorubicin), doxorubicin (doxorubicin), doxorubicin epitaxial (epirubicin), doxorubicin (idarubicin) costume, mitogenic (mitomycin) erythromycin, mitogenic mitt and C (mitomycin-C)-erythromycin (mitramycin) erythromycin a selected from the group consisting of hematopoietic characterized by a more than one pharmaceutical composition for treating and prevention of toxicity. According to Claim 5, said phase rational nitrification enzyme inhibitors irinotecan has number (topoisomerase inhibitor) (irinotecan), camping camptothecin (camptothecin), norbornene (novobiocin) biot new, doxorubicin epitaxial (epirubicin), an Azithromycin [...] (dactinomycin), (amsacrine) clean cancerous company, [...] (etoposide) etoposide and (teniposide) selected from the group consisting of a more than one hematopoietic characterized by pharmaceutical composition for treating and prevention of toxicity. According to Claim 5, said taxane (taxane) based the drug is an paclitaxel (paclitaxel) or docetaxel (docetaxel) to dynes either or both hematopoietic characterized by pharmaceutical composition for treating and prevention of toxicity. Opening chuck useful as anti-containing health food for prevention and improvement of hematopoietic of toxicity. According to Claim 9, said extract water, ethanol or mixtures thereof as solvent extraction of the hematopoietic characterized by health food for prevention and improvement of of toxicity. According to Claim 9, said hematopoietic toxicity induced by anticancer agents to hematopoietic characterized by health food for prevention and improvement of of toxicity. Anticancer (concentration) Paclitaxel (nm) Irinotecan (µm) Doxorubicin (µm) 0.0 0.0 0.0 1.0 1.0 0.1 3.0 5.0 0.5 10.0 10.0 1.0 50.0 50.0 5.0 100.0 100.0 10.0
