Apparatus and method for intravascular catheter navigation using the electrical conduction system of the heart and control electrodes

A new apparatus, algorithm, and method are introduced herein to support navigation and placement of an intravascular catheter using the electrical conduction system of the heart (ECSH) and control electrodes placed on the patient's skin.

Huber needle with safety sheath

The Huber needle assembly employs a straight needle with a bent distal end and a sheath of frusto-conical shape that tethers a cap to the housing in which the Huber needle is secured. The cap is movable from the housing to have the sheath cover the needle and carries a torsion spring that has a leg that snaps across a bore in the cap through which the distal end of the needle passes to block a return movement of the needle through the bore.

SAFETY NEEDLE WITH COLLAPSIBLE SHEATH

A safety needle device includes a housing, a Huber needle, a cap and a sheath. The Huber needle has a first needle leg disposed in the housing and a second needle leg extending perpendicularly of the first needle leg. The cap is disposed over the second needle leg and is movable relative thereto from a first position with the second needle leg extending through the cap to a second position with a tip of the needle disposed in sealed relation in the cap. The sheath is concentrically disposed on and about the needle in a collapsed state, and secured to and between the housing and the cap. The sheath is extendable from the collapsed state to an extended state in response to movement of the cap from the first position to the second position. 1. In combination:a housing;a Huber needle having a first needle leg disposed in the housing and a second needle leg extending perpendicularly of the first needle leg;a cap disposed over the second needle leg, the cap movable relative to the second needle leg from a first position with the second needle leg extending through the cap to a second position with a tip of the needle disposed in sealed relation in the cap; anda sheath concentrically disposed on and about the needle in a collapsed state, and secured to and between the housing and the cap, the sheath extendable from the collapsed state to an extended state in response to movement of the cap from the first position to the second position.2. The combination according to claim 1 , wherein the cap is in contact with the housing in the first position.3. The combination according to claim 2 , further comprising means for releasably locking the cap to the housing.4. The combination according to claim 3 , wherein the means includes a recess in one of the housing and the cap claim 3 , and a projection on the other of the housing and the cap claim 3 , the projection snap-fitting into the recess.5. The combination according to claim 1 , wherein the cap includes a locking element ...

APPARATUS AND METHOD FOR CATHETER NAVIGATION USING ENDOVASCULAR ENERGY MAPPING

Devices and methods for obtaining and using endovascular electrograms in a number of clinical applications and settings are disclosed. In one embodiment, a method is disclosed for locating an indwelling medical device within a vasculature of a patient. The method comprises identifying an endovascular ECG waveform complex from an endovascular ECG signal associated with the indwelling medical device, then calculating an absolute value of the energy of the endovascular ECG waveform complex over a predetermined segment thereof. A position of the medical device within the vasculature is then determined by observation of the absolute value of the energy of the predetermined segment of the endovascular ECG waveform complex. 1. A method for locating an indwelling medical device within a vasculature of a patient , the method comprising:identifying an endovascular ECG waveform complex from an endovascular ECG signal associated with the indwelling medical device;calculating an absolute value of the energy of the endovascular ECG waveform complex over a predetermined segment thereof; anddetermining a position of the medical device within the vasculature by observation of the absolute value of the energy of the predetermined segment of the endovascular ECG waveform complex.2. The method for locating as defined in claim 1 , wherein the method is at least partially performed with an ECG signal monitoring system including a display for depicting the endovascular ECG signal claim 1 , and wherein determining the position includes observing information relating to the absolute value of the energy of the endovascular ECG waveform complex as depicted on the display.3. The method for locating as defined in claim 1 , wherein the endovascular ECG waveform complex includes both positive energy values and negative energy values claim 1 , and wherein identifying the endovascular ECG waveform complex includes identifying two successive peaks of an R-wave.4. The method for locating as defined ...

Systems and methods for guiding a medical instrument

A guidance system for assisting with the insertion of a needle into a patient body is disclosed. The guidance system utilizes ultrasound imaging or other suitable imaging technology. In one embodiment, the guidance system comprises an imaging device including a probe for producing an image of an internal body portion target, such as a vessel. One or more sensors are included with the probe. The sensors sense a detectable characteristic related to the needle, such as a magnetic field of a magnet included with the needle. The system includes a processor that uses data relating to the sensed characteristic to determine a 3-D position of the needle. The system includes a display for depicting the position of the needle. In other embodiments, a guidance system for guiding rigid or other medical instruments is disclosed, together with various example implementations thereof. 1. A tracking system for a medical device , the medical device including a distal portion for insertion into the body of a patient and a proximal portion remaining external to the patient body , the proximal portion of the medical device at least temporarily associated with a magnetic element , the system comprising: a processor that computes position data of the medical device according to detection of the magnetic element; and', 'a memory for storing the position data;, 'a tracking circuit to track movement of the medical device, the tracking circuit includinga first medical imaging system for imaging a first body portion of the patient, the first medical imaging system including an interface for communicating information relating to the position data of the medical device; anda second medical imaging system for imaging a second body portion of the patient.2. The tracking system as defined in claim 1 , wherein the interface includes a display of a first medical imaging system claim 1 , and wherein the information communicated by the display includes an image of a distal portion of the medical device ...

Methods and Apparatus for Inserting Multi-Lumen Split-Tip Catheters Into a Blood Vessel

Methods and apparatus are disclosed for inserting flexible, multi-lumen catheters into blood vessels, and in particular, for inserting flexible, split-tip catheters into blood vessels. The invention accomplishes these objects by temporarily stiffening each catheter lumen and tip independently through use of intra-catheter stiffener elements disposed within the catheter lumens. This provides means for advancing the catheter/stiffeners assembly through a subcutaneous tunnel, and over a plurality of guidewires until a distal tip of the catheter is at a desired position within the vessel. The intra-catheter stiffener elements are sufficiently stiffening to allow advancing the catheter over guidewires, but sufficiently flexible to allow bending and looping of the catheter for proper placement within the vessel.

POPPET VALVE ASSEMBLY FOR CONTROLLING A PNEUMATIC ACTUATOR

A poppet valve assembly to control a pneumatic actuator may include a housing having a central bore. A first module may be disposed within the central bore, and the first module may have a first and second poppet valve. A second module may also be disposed within the central bore, and the second module may have a third and fourth poppet valve. A supply of pressurized fluid may be in fluid communication with a plurality of control valves such that pressurized fluid from the control valves opens and closes the poppet valves. The supply of pressurized fluid may also be in fluid communication with the first module and the second module such that the opening and closing of the poppet valves controls the position of the pneumatic actuator. 1. A poppet valve assembly comprising:a valve housing having a central bore;a first module disposed within the central bore, the first module comprising a first normally closed poppet valve and a second normally closed poppet valve, wherein each of the first and second normally closed poppet valves has an open position and a closed position;a central port formed in the first module, wherein the central port of the first module is adapted to be coupled to a first volume of a pneumatic cylinder;an exhaust port formed in the first module such that the central port is in fluid communication with the exhaust port when the first poppet valve is in the open position; anda supply port formed in the first module such that the central port is in fluid communication with the supply port when second poppet valve is in the open position,wherein the supply port is configured to be in fluid communication with a supply of pressurized fluid such that when the second poppet valve is in the open position, pressurized fluid is provided to the first volume of the pneumatic cylinder, andwherein the exhaust port is configured to vent pressurized fluid from the first volume of the pneumatic cylinder when the first poppet valve is in the open position.2. The ...

Device for Removing a Huber Needle from a Patient

A one-piece connector for removing a housing and needle of a Huber needle assembly from a patient. The connector has a frame that can be positioned about a surface on the housing of the needle assembly and a pair of wings that pivot toward one another to provide a gripping surface. 1. A device for removing a Huber needle from a patient , comprising: a first wall adjacent a first side of the needle;', 'a second wall adjacent a second side of the needle opposite the first side; and', 'a flange extending laterally across the top of the first wall and the second wall to form an overhang thereover; and, 'a housing mounted on the Huber needle, including an opening having a first side adjacent the first wall and a second side adjacent the second wall, the first and second sides engaging the flange as the needle is removed from the patient; and', 'a first wing adjacent the opening first side and a second wing adjacent the opening second side, the first and second wings hinged to the frame to permit pivoting toward one another., 'a connector having a flat apertured frame disposed on the housing, including2. The device according to claim 1 , wherein the connector further includes a projection extending into the opening between the first and second sides.3. The device according to claim 2 , wherein the flange includes a recess at an end thereof claim 2 , the recess receiving the projection.4. The device according to claim 1 , wherein the connector is a one-piece body of plastic.5. The device according to claim 4 , wherein the plastic is a semi-rigid polypropylene.6. The device according to claim 1 , wherein the first and second wings have a trapezoidal shape claim 1 , and each includes a trapezoidal-shaped aperture.7. The device according to claim 1 , wherein the first wing includes a recess at an end thereof and the second wing includes a projection at an end thereof that is received by the recess of the first wing when the first and second wings are pivoted into contact with ...

VALVE SIGNATURE DIAGNOSIS AND LEAK TEST DEVICE

A valve signature diagnosis and leak testing device includes a spool valve operatively connected to a pilot valve, the pilot valve being configured to position the spool valve to one of an open position and a closed position. A blocker valve is fluidly connected to a control fluid outlet of the spool valve. An electrical module is operatively connected to the pilot valve, a supply of control fluid, and the blocker valve, the electrical module being capable of sending pulsed electrical signals to the pilot valve and the blocker valve to selectively position the spool valve and the blocker valve to an open or closed position. 1. A valve signature diagnosis and leak testing device for a control valve , the valve signature diagnosis and leak testing device comprising:a spool valve operatively connected to a pilot valve, the pilot valve being configured to position the spool valve to one of an open position and a closed position, the spool valve including a first control fluid inlet, a first control fluid outlet, and a second control fluid outlet, the first control fluid inlet being fluidly connected to a supply of control fluid and the first control fluid outlet being configured to be connected to a valve actuator;a blocker valve fluidly connected to the second control fluid outlet; andan electrical module operatively connected to the pilot valve, the supply of control fluid, and the blocker valve, the electrical module being capable of sending pulsed electrical signals to the pilot valve and the blocker valve to selectively position the spool valve and the blocker valve to an open or a closed position,wherein the open position of the spool valve fluidly connects the first control fluid inlet to the first control fluid outlet and the closed position of the spool valve fluidly connects the first control fluid outlet to the second control fluid outlet.2. The valve signature diagnosis and leak testing device of claim 1 , wherein the electrical module includes a main ...

WIRELESS MONITORING AND CONTROL OF SAFETY STATIONS IN A PROCESS PLANT

A safety station for use in a process plant includes one or more leverless limit switches to detect activation of one or more parts of the safety station. The safety station further includes a wireless transmitter coupled to the leverless limit switches to transmit signals associated with the safety station to a base station device, which is communicatively coupled to one or more control and/or monitoring devices. 1. A safety station for use in a process plant , the safety station comprising:one or more leverless limit switches to detect activation of one or more parts of the safety station; anda wireless transmitter coupled to the leverless limit switches to transmit signals associated with the safety station to a base station device, wherein the base station device is communicatively coupled to one or more control and/or monitoring modules.2. The safety station of claim 1 , wherein the leverless limit switch is a GO® switch manufactured by the TopWorx corporation.3. The safety station of claim 1 , wherein the leverless limit switch remains latched until physically reset.4702. The safety station of claim 1 , wherein the wireless transmitter is the Rosemount dual input transmitter manufactured by the Emerson corporation.5. The safety station of claim 1 , wherein the wireless transmitter is an intrinsically safe wireless transmitter.6. The safety station of claim 1 , wherein the safety station is a safety shower and/or an eye wash station.7. The safety station of claim 1 , wherein at least one of the one or more control and/or monitoring stations is a remote touch screen panel.8. The safety station of claim 1 , wherein at least one of the one or more control and/or monitoring stations is a paperless recorder.9. The safety station of claim 1 , wherein at least one of the one or more control and/or monitoring stations is a workstation.10. A safety station monitoring and control system in a process plant claim 1 , the system comprising:one or more safety stations ...

SWITCH MODULE

A switch module used for position sensing may be operated in a number of modes for compatibility with a number of legacy position sensing products. A dry switch circuit can be configured to provide a direct output, emulating dry reed, high-side or low-side switched configurations. Alternatively, the dry switch circuit can be connected to an input of a NAMUR circuit to provide the known current output for that standard. In another configuration the dry switch can be selectively coupled to one of two NAMUR circuits allowing the switch module to provide a low-to-high current NAMUR output or a high-to-low current NAMUR output. 1. A switch module arranged and adapted to report a position of a moveable element external to the switch module , the switch module comprising:a first external connection, a second external connection, and a third external connection;a dry contact relay having a relay contact position responsive to a position of a component external to the switch module, the dry contact relay having a common connection, a normally open connection and a normally closed connection, where the normally open connection corresponds to a first position of the moveable element and the normally closed connection corresponding to a second position of the moveable;a NAMUR circuit having a first input connection pair and a first output connection pair;an electrical connection from the normally open connection of the dry relay to a first input of the first input connection pair of the NAMUR circuit;a selector operable to connect the common connection of the dry contact relay to i) a null contact of the selector or ii) a second input of the first input connection pair of the NAMUR circuit;a second electrical connection from the first output of the NAMUR circuit to one of the first external connection or the second external connection; anda third electrical connection between the second output of the NAMUR circuit to the third external connection;a first jumper that removeably ...

Method of Locating the Tip of a Central Venous Catheter

Methods of locating a tip of a central venous catheter (“CVC”) relative to the superior vena cava, sino-atrial node, right atrium, and/or right ventricle using electrocardiogram data. The CVC includes at least one electrode. In particular embodiments, the CVC includes two or three pairs of electrodes. Further, depending upon the embodiment implemented, one or more electrodes may be attached to the patient's skin. The voltage across the electrodes is used to generate a P wave. A reference deflection value is determined for the P wave detected when the tip is within the proximal superior vena cava. Then, the tip is advanced and a new deflection value determined. A ratio of the new and reference deflection values is used to determine a tip location. The ratio may be used to instruct a user to advance or withdraw the tip. 1. A method of determining a location of a tip of a central venous catheter having a lumen filed with an electrolytic material , a portion disposed inside the superior vena cava , a second electrode attached to the skin of a subject , and a first electrode in communication with the electrolytic material , the tip having an opening in communication with the lumen that exposes the electrolytic material inside the lumen to the electrical environment outside the tip , the method comprising:obtaining a reference electrical signal comprising the voltage difference between the first electrode and the second electrode;generating a reference P wave from the reference electrical signal;determining a reference deflection value of the reference P wave;after the tip of the central venous catheter has been moved to a new position, obtaining a new electrical signal comprising the voltage difference between the first electrode and the second electrode;generating a new P wave from the new electrical signal;determining a new deflection value of the new P wave;calculating a ratio of the new deflection value to the reference deflection value;comparing the ratio to a ...

Manufacture of Split Tip Catheters

Multi-lumen catheter devices having at least one split-tipped end are disclosed, together with methods of forming such split tip catheters. In one aspect of the invention, the manufacturing methods can include the steps of: providing a catheter body having at least a first and a second internal lumen extending longitudinally through the catheter body; removing a distal portion of the catheter body to form a first distal tip segment such that the first lumen extends longitudinally within this tip segment beyond the second lumen; and joining a second lumen tip segment to the catheter body in communication with the second lumen. The second tip segment can be joined to the catheter body such that it is at least partially separated from the first tip segment and, in some embodiments, preferably diverges at an angle relative to the first tip segment. 1. A split tip catheter device , comprising:a catheter body;a first distal tip segment having an inner pathway extending longitudinally through a first lumen of the catheter body;a second distal tip segment having a fluid pathway from a second lumen of the catheter body and extending longitudinally through the second tip segment, the second distal tip segment separated from the first distal tip segment; anda bioresorbable adhesive that secures the first and second tip segments together.2. The device according to claim 1 , wherein the bioresorbable adhesive surrounds the first and second distal tip segments forming a continuous outer perimeter.3. The device according to claim 1 , wherein the first distal tip segment is integral with the catheter body claim 1 , and the second distal tip segment is joined to the catheter body.4. The device according to claim 1 , wherein the first distal tip segment is formed from a material different from a material forming the second distal tip segment.5. The device according to claim 4 , wherein one of the first and second distal tip segments is formed of a more flexible material.6. The device ...

Percutaneous Magnetic Gastrostomy

A medical device system includes a needle having a tip including a permanent magnet, and a magnet sensing device including a plurality of sensors configured to detect the magnetic field of the permanent magnet. The magnet sensing device is operable to localize a position of the permanent magnet relative to the magnet sensing device and to indicate a path of the needle on a display. 1. A medical device system , comprising:a needle having a tip including a permanent magnet; anda magnet sensing device including a plurality of sensors configured to detect the magnetic field of the permanent magnet, the magnet sensing device operable to localize a position of the permanent magnet relative to the magnet sensing device and to indicate a path of the needle on a display.2. The system according to claim 1 , wherein the path is a three-dimensional projection.3. The system according to claim 1 , wherein the magnet sensing device includes an audible indicator operable to provide a representation of the position of the permanent magnet relative to the magnet sensing device.4. The system according to claim 1 , further comprising a light emitting element coupled to the magnet sensing device.5. The system according to claim 4 , wherein the light emitting element is configured to provide visible light with sufficient brightness to penetrate tissue of a body such that the light is visible from a location inside the body.6. The system according to claim 4 , wherein the magnet sensing device and the light emitting element are in physically separable housings.7. The system according to claim 4 , wherein the light emitting element is positioned on a face of the magnet sensing device claim 4 , the light emitting element operable to confirm the position of the permanent magnet relative to the magnet sensing device. This application is a continuation of U.S. patent application Ser. No. 12/575,456, filed Oct. 7, 2009, now U.S. Pat. No. 8,437,833, which claims the benefit under 35 U.S.C. §119( ...

Method of Locating the Tip of a Central Venous Catheter

A method of locating a tip of a central venous catheter (“CVC”) having a distal and proximal pair of electrodes disposed within the superior vena cava, right atrium, and/or right ventricle. The method includes obtaining a distal and proximal electrical signal from the distal and proximal pair of electrodes and using those signals to generate a distal and proximal P wave, respectively. A deflection value is determined for each of the P waves. A ratio of the deflection values is then used to determine a location of the tip of the CVC. Optionally, the CVC may include a reference pair of electrodes disposed within the superior vena cava from which a reference deflection value may be obtained. A ratio of one of the other deflection values to the reference deflection value may be used to determine the location of the tip of the CVC.

Device for Removing a Huber Needle from a Patient

A one-piece connector for removing a housing and needle of a Huber needle assembly from a patient. The connector has a frame that can be positioned about a surface on the housing of the needle assembly and a pair of wings that pivot toward one another to provide a gripping surface. 1. A connector for removing a housing and needle from a patient , comprising:a flat apertured frame defining a central opening having a first side and a second side that engage the housing as the needle is removed from the patient; anda first wing adjacent the central opening first side; anda second wing adjacent the central opening second side, the first and second wings hinged to the frame to permit pivoting toward one another.2. The connector according to claim 1 , further comprising a projection extending into the opening between the first and second sides.3. The device according to claim 1 , wherein the connector is a one-piece body of plastic.4. The device according to claim 3 , wherein the plastic is a semi-rigid polypropylene.5. The device according to claim 1 , wherein the first and second wings have a trapezoidal shape claim 1 , and each includes a trapezoidal-shaped aperture.6. The device according to claim 1 , wherein the first wing includes a recess at an end thereof and the second wing includes a projection at an end thereof that is received by the recess of the first wing when the first and second wings are pivoted into contact with one another.7. The device according to claim 1 , wherein each of the first and second wings includes an outwardly extending rib on an underside of a free end thereof to provide a gripping ledge when the first and second wings are pivoted into contact with one another. This is a continuation of U.S. patent application Ser. No. 13/546,891, filed Jul. 11, 2012, now U.S. Pat. No. 8,535,273, which is a continuation of U.S. patent application Ser. No. 12/316,475, filed Dec. 11, 2008, now U.S. Pat. No. 8,231,582, each of which is incorporated by ...

Huber Needle with Safety Sheath

A safety needle assembly is described, including a cap, a housing movable relative to the cap from a first position adjacent the cap to an extended second position spaced from the cap, a hollow needle secured in and extending from the housing, and a collapsible sheath secured to both the cap and the housing. The sheath is concentrically disposed about the needle in a collapsed state with the housing in the first position. The sheath is extendable from the collapsed state to an extended state in response to movement of the housing from the first position to the second position.

Methods and Apparatus for Inserting Multi-Lumen Split-Tip Catheters Into a Blood Vessel

A catheter assembly includes a catheter, a first intra-catheter stiffener element, and a second intra-catheter stiffener element. The catheter includes a first lumen in fluid communication with a first distal opening and a second lumen in fluid communication with a second distal opening. The first intra-catheter stiffener element is configured for disposition through the first lumen such that a distal end thereof extends distally of the first distal opening, the first intra-catheter stiffener element including a first coupler at a proximal end thereof. The second intra-catheter stiffener element is configured for disposition through the second lumen such that a distal end thereof extends distally of the second distal opening, the second intra-catheter stiffener element including a second coupler at a proximal end thereof. 1. A catheter assembly , comprising:a catheter including a first lumen in fluid communication with a first distal opening and a second lumen in fluid communication with a second distal opening;a first intra-catheter stiffener element configured for disposition through the first lumen such that a distal end thereof is distal to the first distal opening, the first intra-catheter stiffener element including a first guidewire lumen; anda second intra-catheter stiffener element configured for disposition through the second lumen such that a distal end thereof is distal to the second distal opening, the second intra-catheter stiffener element including a second guidewire lumen.2. The catheter assembly according to claim 1 , wherein the first intra-catheter stiffener element has a first length and the second intra-catheter stiffener element has a second length less than the first length.3. The catheter assembly according to claim 2 , wherein the first intra-catheter stiffener element includes a first coupler at a proximal end thereof claim 2 , and wherein the second intra-catheter stiffener element includes a second coupler at a proximal end thereof.4. ...

Catheter Tracking and Placement System Including Light Emitting Diode Array

A tracking system configured to track the movement of the medical device. The medical device can include a proximal portion that has a magnetic element attached thereto. The system can include a console with a display, and a TLS sensor. The TLS sensor can be disposed on a surface of the patient and can include an LED array. The LED array can indicate a proximity of the medical device to the TLS sensor. The LED array can provide different colors and/or project images to display information regarding the location, orientation, distance, or depth of the medical device. The display can be disposed on an upper surface of the TLS sensor and can be configured to show an image of the medical device disposed therebelow, along with additional information and imagery, thus providing a standalone unit.

Angled Intraosseous Access System

An angled intraosseous access system including a guide block and/or a guide plate is disclosed. The system includes a driver having a body, and including a needle assembly rotatably coupled thereto, the needle assembly defining a needle axis. One of the guide block or the guide plate is configured to engage a skin surface and align the needle assembly axis at a predetermined angle relative to the skin surface to access the medullary cavity at the predetermined angle. Advantageously, the angled needle of the intraosseous access system can mitigate pain during infusion and mitigate backwalling.

Magnetic Field Direction Detection

A system for magnetic field direction detection when placing a catheter is disclosed, including a sensor configured to track a medical device, the sensor including a magnetic sensor printed circuit board including a plurality of magnetometers arranged in a magnetometer array. The system can include a console coupled to the sensor, including a processor and non-transitory computer-readable medium having stored a plurality of logic modules that when executed by the processor, are configured to perform operations including receiving detected magnetic field strength values detected by the plurality of magnetometers, determining a position on the sensor of each of the plurality of magnetometers, determining the magnetic field source direction based on the detected magnetic field strength values and the position on the sensor of each of the plurality of magnetometers, and displaying the magnetic field source direction on the display.

Needle-Guidance Systems, Devices, and Method Thereof Including RFID Technology

A needle-guidance system is disclosed including single-patient equipment, multi-patient equipment, and an RFID reader-writer. The single-patient equipment can include a vascular access device (“VAD”) having a needle and an RFID tag. The RFID tag can be incorporated into the VAD or packaging for the VAD. The console can be configured to automatically start needle tracking for a clinician on an integrated display screen of the console after receiving RFID-tag data from the RFID tag and processing with a processor of the console instructions of needle-tracking software provided by memory of the console for the needle tracking. The RFID reader-writer can be configured to read the RFID-tag data from the RFID tag and write additional RFID-tag data to the RFID tag. The RFID reader-writer can be provided with the packaging for the VAD or the multi-patient equipment. A method of the needle-guidance system is also disclosed.

Systems and Methods for Infrared-Enhanced Ultrasound Visualization

A system and method for providing enhanced ultrasound images for accessing a vasculature of a patient is disclosed. The system includes an ultrasound imaging device including a probe with a light detector disposed at a distal end thereof. A medical device includes an infrared emitter disposed a distal tip thereof. The emitter provides infrared light that illuminates surrounding tissue. Reflected light is detected and interpreted based on the profile of absorbance spectra which can be used to identify different tissue structures. This light-based information is superimposed on an ultrasound image of the vessel to facilitate first-stick access of patient vasculature.

CONFIGURABLE PROCESS CONTROL DEVICE WITH ELECTRONIC DISPLAY ASSEMBLY

A configurable process control device, which includes a field device, such as a valve position controller, that can be configured by a user to emulate any one of a plurality of different types of process control devices, is provided with an electronic display assembly. The electronic display assembly is operatively connected with a control circuit that is arranged to respond to the specific configuration of the field device to cause the electronic display assembly to display information relevant to the specific type of control device the field device has been configured to emulate. The information may include safety certification information specific to each of the different types of process control devices that the field device can be configured to emulate. 1. A configurable process control device for use in a plurality of use environments , wherein at least one of a pre-defined plurality of certifications must be displayed in conjunction with the configurable process control device depending on which of the use environments the configurable process control device is to be used in , the configurable process control device comprising:a field device;a first control circuit operatively coupled to the field device, the first control circuit arranged to control the field device and arranged to be reconfigured by a user to allow the field device to selectively emulate any of a plurality of different process control device types;an electronic display assembly, the electronic display assembly arranged to selectively display different information; anda second control circuit, the second control circuit operatively coupled to the electronic display assembly and the first control circuit, the second control circuit having access to a plurality of different certification information sets, each certification information set corresponding to a different one of the plurality of different process control device types;wherein the second control circuit causes the electronic display ...

Devices and Systems for Navigation and Positioning a Central Venous Catheter Within a Patient

Devices and systems for navigation and positioning a central venous catheter within a patient. In an exemplary embodiment of a system of the present disclosure, the system comprises a first pole and a second pole, the first pole and the second pole configured to generate an electric field within a mammalian body sufficient to obtain a plurality of field measurements therein, and an elongated body configured for at least partial insertion into a blood vessel of the mammalian body and advancement through a vasculature, said advancement dependent upon the plurality of field measurements indicative of one or more locations of a portion of the elongated body within the vasculature. In at least one embodiment, the elongated body is configured as a stylet.

Fenestration Coverings, Procedural Drapes, and Methods Thereof

Disclosed are fenestration coverings, procedural drapes, and methods thereof. For example, a fenestration covering is configured to cover a fenestration in a procedural drape for a medical procedure. The fenestration covering includes a transparent sheet of polymeric material and a non-adhesive central portion of the fenestration covering. The transparent sheet has a length and width sufficient to cover the fenestration and allow a clinician to manipulate the patient, one or more pieces of procedural equipment or supplies, or a combination thereof under the fenestration covering. The central portion of the fenestration covering is greater than or coextensive with the fenestration. An example method includes forming a fenestration in one or more procedural drapes for a medical procedure and covering the fenestration with the fenestration covering.

Magnetic Trajectory Prediction and Position Identification

Embodiments disclosed herein are directed to trackable medical device, e.g. a catheter placement system, having a needle formed of a magnetizable material, and magnetized to produce a magnetic field having a magnetic field strength or a magnetic field signature detectable by a sensor of a tracking system. The medical device further includes a spring formed of a non-magnetizable material, e.g. silver coated copper beryllium or the like, and configured to display the same mechanical performance properties as a spring formed of the magnetizable material. Also disclosed is a method of tracking a medical device including magnetizing the catheter placement system to produce a magnetic field having a strength or a magnetic field signature and detecting the magnetic field by a sensor of a tracking system.

PIEZOELECTRIC LOUDSPEAKER

The present invention discloses a piezoelectric loudspeaker. The piezoelectric loudspeaker comprises a sound producing plate, a resonant sound-box, a surround and a reflective sound-box. The sound producing plate comprises a piezoelectric ceramic element. The resonant sound-box includes a first opening comprising a first carrying part. The sound producing plate is disposed on the first carrying part. A cavity resonator is formed between the sound producing plate and the resonant sound-box. The surround is disposed between the first carrying part and the sound producing plate. The reflective sound-box includes a second opening and a reflective output opening. The second opening comprises a second carrying part. The resonant sound-box is disposed on the second carrying part. A reflective cavity body is formed between the resonant sound-box and the reflective sound-box, and the reflective cavity body is connected the reflective output opening. 1. A piezoelectric loudspeaker , comprising:a sound producing plate including at least one piezoelectric ceramic element being able to vibrate the sound producing plate;a resonant sound-box including a first opening comprising a first carrying part, the sound producing plate being disposed on the first carrying part, and a cavity resonator being formed between the sound producing plate and the resonant sound-box;a surround disposed between the first carrying part and the sound producing plate; anda reflective sound-box including a second opening and a reflective output opening, a second carrying part formed on a partial of an inner edge of the seconding opening, the resonant sound-box being disposed on the second carrying part, a reflective cavity body being formed between the resonant sound-box and the reflective sound-box, the reflective output opening being disposed on a side of the reflective sound-box, and the reflective cavity body being communicating with the reflective output opening.2. The piezoelectric loudspeaker of ...

Various Operating Mechanisms for Intraosseous Access Medical Devices and Methods Thereof

Disclosed herein are intraosseous access devices having various operating mechanisms, as well as methods of the intraosseous access devices. For example, an intraosseous access device includes, in some embodiments, a constant-torque spring assembly, a drive shaft, an intraosseous needle, and an interlock mechanism. The constant-torque spring assembly is disposed in a housing, and the drive shaft extends from the housing. The drive shaft is coupled to the constant-torque spring assembly. The intraosseous needle is coupled to the drive shaft. The intraosseous needle is configured for drilling through bone and providing intraosseous access to a medullary cavity of a patient. The interlock mechanism is configured to prevent rotation of the intraosseous needle and the drilling therewith until the interlock mechanism is disengaged.

Probe Shield

Disclosed herein is a needle shield for an ultrasound probe. The needle shield fits closely with an ultrasound probe head, and any associated structures, and prevents accidental damage from needle punctures and the like. Further the needle shield includes a guide wedge that allows a user to stabilize the probe at an angle relative to the skin surface. This allows perpendicular needle access to the target vessel without the probe obstructing the needle. Further the needle shield includes an acoustic lens to modify the acoustic beam and compensate for the angle position of the probe head.

Wireless Medical Device Powering System

Disclosed herein is a wireless medical device powering system configured to power an untethered medical device including a first medical device having an induction receiving coil, the induction receiving coil in communication with each of one or more electrical systems and a first medical device console comprising one or more processors, a non-transitory computer readable medium, and a plurality of logic modules. The system can include a wireless powering device configured to wirelessly provide power to the first medical device, the wireless powering device having a body including an induction transmitting coil.

Systems and Methods for Ultrasound-And-Bioimpedance-Based Guidance of Medical Devices

Disclosed are systems and methods for ultrasound-and-bioimpedance-based guidance of medical devices. A system can include an ultrasound probe, a needle, a console, and a display screen. The ultrasound probe is configured to emit ultrasound pulses and receive reflected ultrasound pulses reflected back through one or more tissues for producing ultrasound images. The needle can be configured to emit, detect, or alternately emit and detect electrical currents passed through the one-or-more tissues disposed between a pair or more of system electrodes for measuring bioimpedance. The console can be configured to instantiate one or more console processes for the ultrasound-and-bioimpedance-based guidance with the ultrasound probe and the needle. The display screen is configured to display a graphical representation of the needle among anatomical features of the patient in the ultrasound images confirmed by the bioimpedance of the one-or-more tissues previously or instantly disposed between the pair-or-more of system electrodes.

In-Line Suspension Ultrasound Rollstand

Disclosed herein is a system, apparatus and method directed to stabilizing a rollstand for an ultrasound system. The system, apparatus and method pertain to a rollstand comprising a base, an off-center vertical support, and an overhanging support for an ultrasound display of the ultrasound system. The off-center vertical support rises vertically from the base and is offset horizontally from a centroid of the base. A center of gravity of the rollstand may be located above the centroid of the base and above a vascular site of a patient being imaged by the ultrasound system. The overhanging support may be offset horizontally from the centroid of the base in a direction substantially opposite the off-center vertical support.

Multi-Purpose Delivery Needle

A needle for accessing a vasculature of a patient is disclosed. The cannula of the needle includes a fluid lumen extending from the distal end to the proximal end and a guideway lumen extending proximally away from the distal end. The guideway lumen is configured for placement of a guidewire therein, and the guideway lumen includes a guideway slot extending along a length of the guideway lumen, where the guideway slot extends radially through a guideway-lumen wall and extends along the guideway lumen to the distal end. Also disclosed is a sheath covering the cannula and the sheath includes a separable portion through which guidewire may laterally pass. Also disclosed is a collar rotatably positionable between a guidewire secure position and a guidewire release position.

Method of Locating the Tip of a Central Venous Catheter

Methods of locating a tip of a central venous catheter (“CVC”) relative to the superior vena cava, sino-atrial node, right atrium, and/or right ventricle using electrocardiogram data. The CVC includes at least one electrode. In particular embodiments, the CVC includes two or three pairs of electrodes. Further, depending upon the embodiment implemented, one or more electrodes may be attached to the patient's skin. The voltage across the electrodes is used to generate a P wave. A reference deflection value is determined for the P wave detected when the tip is within the proximal superior vena cava. Then, the tip is advanced and a new deflection value determined. A ratio of the new and reference deflection values is used to determine a tip location. The ratio may be used to instruct a user to advance or withdraw the tip. 1. A method of determining in which portion of the atrium a tip of a central venous catheter is located , the method comprising:obtaining an electrical signal from a portion of the atrium adjacent the tip of the central venous catheter;generating a P wave from the electrical signal;determining a greatest positive deflection value for the reference P wave;determining a smallest negative deflection value for the reference P wave;calculating a ratio of the greatest positive deflection value to the smallest negative deflection value;comparing the ratio to a first threshold value;if the ratio is less than the first threshold value, determining the tip is in the upper atrium;comparing the ratio to a second threshold value;if the ratio is greater than the second threshold value, determining the tip is in the lower atrium; andif the ratio is greater than or equal to the first threshold value, and the ratio is less than or equal to the second threshold value, determining the tip is in the mid atrium.2. A computer-readable medium storing computer executable instructions for directing a processor to:obtain a reference deflection value from a reference electrical ...

Item Eligibility and/or Promotion Determination Application

In general, the present invention is directed to systems and methods of utilizing an application operating on a mobile device to determine any applicable offers or eligibility and rank such offers and eligibility for user selection. More specifically, a process may be conducted by a processor in communication with a mobile device and data stores including user data, retailer data, and/or product and service data, the process including comparing identification information associated with a product or service received from the mobile device with data in the data stores; determining the product or service and identifying any associated promotional offers or plan eligibility associated with the product or service, the user, and/or the retailer; ranking any promotional offers or plan eligibility based at least in part on size of promotion; transmitting to the mobile device an identifier of applicable promotional offers or plan eligibility. 1. A system , comprising:a processor; user data, including memberships, groups, plans, and/or entitlements associated with a user;', products and services offered by a retailer;', 'any promotional offers offered by the retailer;, 'retailer data, including, 'product and service data, including identification information of each product and service, and any promotional offers or plan eligibility associated with the product or service;, 'one or more data stores, the one or more data stores storing data comprisingwherein the processor is in selective communication with one or more retailers, manufacturers, membership plans, insurance providers, and/or entitlement providers to populate and update the one or more data stores;wherein the processor is in selective communication with a mobile device of the user; comparing first media data comprising identification information associated with a product or service received from the mobile device with product and service data stored in the one or more data stores;', 'based at least in part on the ...

QUICK DISCONNECT CONNECTOR ASSEMBLY

A quick-disconnect connector assembly includes a housing having a bore that extends up to but not through a first end of the housing. The connector assembly also includes a proximity switch disposed within the bore, and the proximity switch includes a switch body, a first contact member, and a second contact member. A portion of each of the first and second contact members extends from the switch body towards a second end of the housing. In a first switch position, a contact of a displaceable switching assembly is in contact with the first contact member, and in a second switch position, the contact is in contact with the second contact member. The connector assembly also includes an external connection assembly including a first pin that is electrically coupled to the first contact member and a second pin that is electrically coupled to the second contact member. 1. A quick-disconnect connector assembly comprising:a housing that extends along a longitudinal axis from a first end to a longitudinally-opposite second end, the housing including one or more interior surfaces that cooperate to define a bore that extends from the second end to a point adjacent to the first end such that the bore does not extend through the first end of the housing, wherein the bore includes a first bore portion; a switch body extending along a body longitudinal axis, the switch body having a first end disposed adjacent to the first end of the housing and a longitudinally-opposite second end; and', 'a first contact member and a second contact member, each of the first and second contact members having a first end and a longitudinally-opposite second end, the second end being disposed within the switch body and the first end being disposed external to the switch body, wherein a portion of each of the first and second contact members extends from the second end of the switch body towards the second end of the housing,', 'wherein in a first switch position, a contact of a displaceable ...

Wound-Healing Systems and Methods Thereof

Disclosed herein are wound-healing systems and methods thereof. A wound-healing system can include a wound dressing, a catheter-stabilization device, and an electrical-stimulation means for applying electrical stimulation to heal or protect at least a wound associated with a percutaneous insertion site of a patient. The wound dressing can be configured as an electrode for placement around the wound. The catheter-stabilization device can include an anchor pad and a retainer coupled to the anchor pad. The anchor pad can be configured to adhere to skin of the patient proximate the insertion site. The retainer can be configured to stabilize a catheter assembly while a catheter tube of the catheter assembly is disposed in the insertion site. The electrical-stimulation means can include an electrical power source and an external circuit between the catheter-stabilization device and the wound dressing for applying the electrical stimulation.

Adjustable orthotic foot brace and method for adjusting a foot brace

The orthotic foot brace for a person wearing a footwear generally has: a lower leg holder securable to a lower leg of the person for use, a lower leg strut connected to the lower leg holder and extending downwardly towards the footwear during use; a foot strut structurally connected to the lower leg strut and having at least one side portion, each side portion extending forwardly along a respective side of the footwear and extending outwardly along a respective side of the footwear; an instep strut provided in the form of an extension of the foot strut along a long axis of the footwear, the instep strut having a distal portion securable to the footwear, and at least a proximal portion being slidably connected to the foot strut in a manner to allow adjusting the extension distance of the distal portion to a selected position.

Devices for Usage in Tracking and Imaging

Embodiments disclosed herein are directed to devices that include 17-7 precipitation hardened stainless steel and can be magnetized to provide a magnetic field. The magnetic field can be detected by a tracking system that determines a location of the device, for example within a patient. The device formed of 17-7 precipitation hardened stainless steel can display superiority in magnetic tracking properties, including an improved immunity to magnetic interference and improved pairing and drop-out distance. This is of particular importance where tracking systems are highly sensitive to interference magnetic sources, such as smart phones or the like, and which would otherwise need careful calibration or complex algorithms to account for such interferences.

TRACEABLE METALLIC PRODUCTS AND METALLIC SUPPORT FOR NANOSTORAGE

The invention relates to traceable metallic products, methods of uses and methods of making same. The metallic products may be made traceable for integrity purposes, identification purposes, counterfeit avoidance and the like. The invention also relates to metallic supports for nanostorage of various compounds and samples. 1. A traceable metallic product , wherein said metallic product comprises a porous surface layer formed by anodization , and wherein said porous surface layer comprises at least one traceable biological compound.2. (canceled)3. The traceable metallic product of claim 1 , wherein said at least one traceable biological compound is selected from the group consisting of nucleic acids claim 1 , peptidic molecules claim 1 , lipids claim 1 , mono and polysaccharides claim 1 , hormones claim 1 , vitamins claim 1 , and derivatives thereof.4. (canceled)5. The traceable metallic product of claim 1 , wherein said at least one traceable biological compound is carried in nanopores of the porous surface layer claim 1 , and wherein said at least one traceable compound is recoverable from said porous surface layer for detection claim 1 , identification and/or utilization purposes.6. (canceled)7. The traceable metallic product of claim 1 , wherein said traceable metallic product consists of a metallic support for nanostorage of compound and samples.8. The traceable metallic product of claim 1 , wherein said porous surface layer is sealed.9. The traceable metallic product of claim 1 , wherein said porous surface layer further comprises an electrodeposit of at least one metal selected from the group consisting of silver claim 1 , gold claim 1 , copper claim 1 , nickel claim 1 , zinc claim 1 , tin claim 1 , cadmium claim 1 , palladium and platinum.10. The traceable metallic product of claim 1 , wherein said traceable metallic product consists of a traceable piece of aluminum comprising a porous surface layer formed by anodization claim 1 , and wherein said porous ...

Rapidly Insertable Central Catheters Including Catheter Assemblies and Methods Thereof

Rapidly insertable central catheters (“RICCs”) including catheter assemblies and methods thereof are disclosed. For example, a RICC assembly includes a RICC and an introducer. The RICC includes a catheter tube, a catheter hub, and one or more extension legs coupled in the foregoing order. The catheter tube includes a side aperture that opens into an introducing lumen that extends from at least the side aperture to a distal end of the RICC. The introducer includes a retractable-needle device, a syringe, and a coupling hub that couples the retractable-needle device and the syringe together proximal of the side aperture in a ready-to-deploy state of the RICC assembly. The retractable-needle device includes an introducer needle. A needle tip in a distal-end portion of a shaft of the introducer needle extends beyond the distal end of the RICC when the RICC assembly is in the ready-to-deploy state of the RICC assembly.

Intraosseous Device Including a Sensing Obturator

Disclosed herein are medical device systems, and methods thereof, for automatically detecting access to a medullary cavity. Embodiments include intraosseous access systems with sensing obturators, configured to detect a change in modality, e.g. pressure, oxygen saturation, electrical impedance, etc. at a distal tip thereof. Signals can be transmitted to a control logic that can modify the activation of a driver in response. Signals can be transmitted by way of wired or wireless communication. In an embodiment, signals can be transmitted through conductive polymer material that forms the obturator and allows the obturator to be flexible enough to mitigate accidental needle stick injuries.

Guidewire Advancement And Blood Flashback Systems For A Medical Device Insertion System

Embodiments of the present invention are directed to guidewire advancement and blood flashback systems. In particular, the insertion tool includes a frangible guidewire lever configured to break and prevent further movement of the guidewire if the guidewire becomes caught. Such a feature can prevent breakage of a distal portion of the guidewire which otherwise could undesirably lead to an embolism. The insertion tool can further include a blood flash indicator that has a simplified coupling with the needle. The insertion tool can further include a guidewire advancement assembly configured to allow the clinician to hold the insertion tool proximate a distal end and operate the guidewire advancement with one hand while providing increased control over the insertion tool. The insertion tool can further include a safety clip coupled with the catheter hub and configured to close about the needle tip when the catheter is detached from the device.

Systems And Methods For Visualizing Anatomy, Locating Medical Devices, Or Placing Medical Devices

A medical device-placing system including a medical-device tip-location sensor (“TLS”) configured for placement on a chest of a patient, an ultrasound probe, a console, and an alternative-reality headset. The ultrasound probe can be configured to emit ultrasound signals into the patient and receive echoed ultrasound signals from the patient. The console can be configured to transform the echoed ultrasound signals to produce ultrasound-image segments corresponding to anatomical structures of the patient, as well as transform TLS signals from the TLS into location information for a medical device within the patient. The alternative-reality headset can include a display screen through which a wearer of the alternative-reality headset can see the patient. The display screen can be configured to display over the patient a virtual medical per the location information for the medical device within objects of virtual anatomy corresponding to the ultrasound-image segments.

VALVE SIGNATURE DIAGNOSIS AND LEAK TEST DEVICE

A valve signature diagnosis and leak testing device includes a spool valve operatively connected to a pilot valve, the pilot valve being configured to position the spool valve to one of an open position and a closed position. A blocker valve is fluidly connected to a control fluid outlet of the spool valve. An electrical module is operatively connected to the pilot valve, a supply of control fluid, and the blocker valve, the electrical module being capable of sending pulsed electrical signals to the pilot valve and the blocker valve to selectively position the spool valve and the blocker valve to an open or closed position.

Conductance Based Digital Blood Flash Indicator Device

Embodiments disclosed herein are generally directed to blood flash detection systems and methods thereof. Embodiments include an indicator device including a needle and needle hub, defining a lumen and in fluid communication with a medical line. The needle hub includes a marker, such as an RFID tag, with electrodes extending to the lumen. When a fluid flow, for example blood, enters the lumen, an electrical connection between the electrodes is bridged, completing the circuit and activating the marker. The marker can then be responsive to an interrogation signal, and can provide a response signal. The response signal can be detected and interpreted by a detection device that indicates to a user that the vasculature has been accessed without the user directly observing the insertion site or the device.

Magnetizing system for needle assemblies including orientation key system for positioning needle tray in magnetizer

A magnetizing system for use in selectively magnetizing a needle of a medical device is disclosed. Once magnetized, the needle can be tracked by a needle guidance system, which assists the clinician placing the needle by visualizing on a display the position and orientation of the needle after its insertion into a body of a patient. An orientation key system is included with the magnetizing system to ensure the needle is positioned correctly in the magnetizing system. This in turn ensures that the needle is properly magnetized so as to be accurately tracked by the needle guidance system. In one embodiment a first key is included with the magnetizing system and configured to cooperatively mate with a second key included with the needle of the medical device. Various types of keys are disclosed herein.

用于针组件的磁化系统

公开了一种用于选择性地使医疗设备的针磁化的磁化系统。一旦被磁化，可以通过针引导系统来跟踪所述针，所述系统通过在所述针插入患者体内后在显示器上显示所述针的位置和定向来帮助临床医生放置所述针。定向键系统随所述磁化系统被包括，以确保将所述针正确定位在所述磁化系统中。这继而确保使所述针被适当地磁化，以便被所述针引导系统准确地跟踪。在一个实施方案中，第一键随所述磁化系统被包括并被配置成与随所述医疗设备的针被包括的第二键协作地配合。本文公开了各种类型的键。

Implantable, refillable infusion device and septum replacement kit

An implantable infusion device (10) includes a lightweight, inert housing (12) which contains an infusate (18) for administration to a patient, and an enclosed, gas-impermeable variable volume chamber (30) which contains a pressure source, such as propellant, mechanical spring, or the like. The variable volume chamber may be in the form of a rigid-walled expandable bellows structure or a nonstretchable flexible bag and is attached to the housing so as not to obstruct the entry port for introduction of infusate. A recharging fluid flow path (31) is provided adjacent to where the variable volume chamber is attached to the housing. The infusate is delivered from the device via a catheter in response to expansion of the variable volume chamber against the volume of infusate in the housing. A separate bolus injection port (38) is provided which allows infusate to be safely introduced directly into the catheter and overrides the controlled pressure-driven delivery. The lightweight housing may include integrally formed needle stops (32 and 34) and suture fastening loops (36).

Method of locating the tip of a central venous catheter

The invention includes a method of locating a tip of a central venous catheter (“CVC”) having a distal and proximal pair of electrodes disposed within the superior vena cava, right atrium, and/or right ventricle. The method includes obtaining a distal and proximal electrical signal from the distal and proximal pair and using those signals to generate a distal and proximal P wave, respectively. A deflection value is determined for each of the P waves. A ratio of the deflection values is then used to determine a location of the tip of the CVC. Optionally, the CVC may include a reference pair of electrodes disposed within the superior vena cava from which a reference deflection value may be obtained. A ratio of one of the other deflection values to the reference deflection value may be used to determine the location of the tip of the CVC.

Method of locating the tip of a central venous catheter

Methods of locating a tip of a central venous catheter (“CVC”) relative to the superior vena cava, sino-atrial node, right atrium, and/or right ventricle using electrocardiogram data. The CVC includes at least one electrode. In particular embodiments, the CVC includes two or three pairs of electrodes. Further, depending upon the embodiment implemented, one or more electrodes may be attached to the patient's skin. The voltage across the electrodes is used to generate a P wave. A reference deflection value is determined for the P wave detected when the tip is within the proximal superior vena cava. Then, the tip is advanced and a new deflection value determined. A ratio of the new and reference deflection values is used to determine a tip location. The ratio may be used to instruct a user to advance or withdraw the tip.

Percutaneous magnetic gastrostomy

A system and method places a percutaneous gastrostomy device into a body cavity of a patient using a magnetic gastrostomy tube and a medical detection sensing device. The magnetic gastrostomy tube has a ferromagnetic element attached to its distal end. Various embodiments allow a needle to be passed from the magnetic detection sensing device outside the patient toward a magnetic gastrostomy tube inside the patient or, alternatively, from the magnetic gastrostomy tube inside the patient toward the magnetic detection sensing device outside the patient. After a needle makes a hole between the outside of the patient and the body cavity, a medical wire may be passed through the hole, and the medical wire can then be used to place the percutaneous gastrostomy device.

Apparatus and method for catheter navigation and tip location

Devices and methods obtain and use endovascular electrograms in a number of clinical applications and settings. In one embodiment, methods for triggering analysis of an endovascular ECG waveform are based on the detection of a peak in a skin-based ECG waveform in order to determine a location of an indwelling medical device, such as a catheter. In another embodiment, the position of a catheter or other medical device within the vasculature can be determined by analysis of the energy profile of a detected P-wave. In yet other embodiments, magnetic connecting devices are used for establishing an operable connection through a sterile field.

Adaptor for endovascular electrocardiography

An adaptor for endovascular electrocardiography includes a member having two ends and an inner lumen such that when one of the ends is connected to a catheter and the other end is connected to a syringe, fluid from the syringe is flushed into the catheter through the inner lumen. The adaptor also includes a metal insert, disposed along the inner lumen of the member, which connects through a sealed electrical connection to the outer side of the member.

Devices and methods for endovascular electrography

An adapter for an endovascular device and a catheter steering device are provided. The adapter for an endovascular device includes a body, a conductive metal ring and a conductive wire. The body includes a first open end, a second open end, a central lumen having a substantially cylindrical surface extending from the first open end to the second open end, and a channel extending from the central lumen to an external opening. The conductive metal ring is attached to the surface of the central lumen, and the conductive wire is coupled to the conductive metal ring and extends through the channel and the external opening. The steering device for a catheter that has a plurality of lumens with spaced distal openings includes a stylet for disposition within one of the plurality of lumens, and a steering member for disposition within a different one of the plurality of lumens. In the installed position, the stylet and the steering member are connected together at respective distal ends such that a portion of the steering member is disposed outside of the distal end of the catheter.

Apparatus and method for catheter navigation using endovascular energy mapping

Devices and methods obtain and use endovascular electrograms in a number of clinical applications and settings. In one embodiment, a method for locating an indwelling medical device within a vasculature of a patient includes identifying an endovascular ECG waveform complex from an endovascular ECG signal associated with the indwelling medical device, then calculating an absolute value of the energy of the endovascular ECG waveform complex over a predetermined segment thereof. A position of the medical device within the vasculature is then determined by observation of the absolute value of the energy of the predetermined segment of the endovascular ECG waveform complex.

Device and method for vascular access

A system for facilitating vascular access is disclosed. The system includes an imaging device including a transducer configured for ultrasound image data acquisition, an ECG signal acquisition device configured to acquire ECG signal data via one or more leads, wherein a first lead is directly connected to skin of a patient, and a mobile application configured to render a graphical user interface to be displayed on a display screen of a mobile device, wherein the graphical user interface illustrates a representation of at least one of the ultrasound image data or the ECG signal data that is wireless transmitted to the mobile device.

Safety-equipped connection systems and methods thereof for establishing electrical connections

Connection systems and methods thereof facilitate establishing electrical connections through a barrier such as a drape without compromising a sterile field established by the barrier. A connection system can include two connectors. A first connector can include a first-connector housing defining a cavity, a slideable end piece coupled to a distal-end portion of the first-connector housing, and at least a first piercing element connected to a first electrical lead. The first piercing element can be configured to enter the cavity and pierce a barrier disposed in the cavity when the slideable end piece is advanced toward a proximal-end portion of the first-connector housing. A second connector can include at least a first receptacle within a second-connector housing connected to a second electrical lead. The first receptacle can be configured to form at least a first electrical connection with the first piercing element after the first piercing element pierces the barrier.

Devices and systems for navigation and positioning a central venous catheter within a patient

Devices and systems for navigation and positioning a central venous catheter within a patient. In an exemplary embodiment of a system of the present disclosure, the system comprises a first pole and a second pole, the first pole and the second pole configured to generate an electric field within a mammalian body sufficient to obtain a plurality of field measurements therein, and an elongated body configured for at least partial insertion into a blood vessel of the mammalian body and advancement through a vasculature, said advancement dependent upon the plurality of field measurements indicative of one or more locations of a portion of the elongated body within the vasculature. In at least one embodiment, the elongated body is configured as a stylet.

Method of locating the tip of a central venous catheter

A method of locating a tip of a central venous catheter (“CVC”) having a distal and proximal pair of electrodes disposed within the superior vena cava, right atrium, and/or right ventricle. The method includes obtaining a distal and proximal electrical signal from the distal and proximal pair of electrodes and using those signals to generate a distal and proximal P wave, respectively. A deflection value is determined for each of the P waves. A ratio of the deflection values is then used to determine a location of the tip of the CVC. Optionally, the CVC may include a reference pair of electrodes disposed within the superior vena cava from which a reference deflection value may be obtained. A ratio of one of the other deflection values to the reference deflection value may be used to determine the location of the tip of the CVC.

Method of locating the tip of a central venous catheter

Methods of locating a tip of a central venous catheter (“CVC”) relative to the superior vena cava, sino-atrial node, right atrium, and/or right ventricle using electrocardiogram data. The CVC includes at least one electrode. In particular embodiments, the CVC includes two or three pairs of electrodes. Further, depending upon the embodiment implemented, one or more electrodes may be attached to the patient's skin. The voltage across the electrodes is used to generate a P wave. A reference deflection value is determined for the P wave detected when the tip is within the proximal superior vena cava. Then, the tip is advanced and a new deflection value determined. A ratio of the new and reference deflection values is used to determine a tip location. The ratio may be used to instruct a user to advance or withdraw the tip.

Method of locating the tip of a central venous catheter

A method of locating a tip of a central venous catheter (“CVC”) having a distal and proximal pair of electrodes disposed within the superior vena cava, right atrium, and/or right ventricle. The method includes obtaining a distal and proximal electrical signal from the distal and proximal pair of electrodes and using those signals to generate a distal and proximal P wave, respectively. A deflection value is determined for each of the P waves. A ratio of the deflection values is then used to determine a location of the tip of the CVC. Optionally, the CVC may include a reference pair of electrodes disposed within the superior vena cava from which a reference deflection value may be obtained. A ratio of one of the other deflection values to the reference deflection value may be used to determine the location of the tip of the CVC.

Method of locating the tip of a central venous catheter

Methods of locating a tip of a central venous catheter (“CVC”) relative to the superior vena cava, sino-atrial node, right atrium, and/or right ventricle using electrocardiogram data. The CVC includes at least one electrode. In particular embodiments, the CVC includes two or three pairs of electrodes. Further, depending upon the embodiment implemented, one or more electrodes may be attached to the patient's skin. The voltage across the electrodes is used to generate a P wave. A reference deflection value is determined for the P wave detected when the tip is within the proximal superior vena cava. Then, the tip is advanced and a new deflection value determined. A ratio of the new and reference deflection values is used to determine a tip location. The ratio may be used to instruct a user to advance or withdraw the tip.

Method of locating the tip of a central venous catheter

A method of locating a tip of a central venous catheter (“CVC”) having a distal and proximal pair of electrodes disposed within the superior vena cava, right atrium, and/or right ventricle. The method includes obtaining a distal and proximal electrical signal from the distal and proximal pair of electrodes and using those signals to generate a distal and proximal P wave, respectively. A deflection value is determined for each of the P waves. A ratio of the deflection values is then used to determine a location of the tip of the CVC. Optionally, the CVC may include a reference pair of electrodes disposed within the superior vena cava from which a reference deflection value may be obtained. A ratio of one of the other deflection values to the reference deflection value may be used to determine the location of the tip of the CVC.

Method of locating the tip of a central venous catheter

A method of locating a tip of a central venous catheter (“CVC”) having a distal and proximal pair of electrodes disposed within the superior vena cava, right atrium, and/or right ventricle. The method includes obtaining a distal and proximal electrical signal from the distal and proximal pair of electrodes and using those signals to generate a distal and proximal P wave, respectively. A deflection value is determined for each of the P waves. A ratio of the deflection values is then used to determine a location of the tip of the CVC. Optionally, the CVC may include a reference pair of electrodes disposed within the superior vena cava from which a reference deflection value may be obtained. A ratio of one of the other deflection values to the reference deflection value may be used to determine the location of the tip of the CVC.

Percutaneous magnetic gastrostomy

A medical device system includes a needle having a tip including a permanent magnet, and a magnet sensing device including a plurality of sensors configured to detect the magnetic field of the permanent magnet. The magnet sensing device is operable to localize a position of the permanent magnet relative to the magnet sensing device and to indicate a path of the needle on a display.

Apparatus and method for catheter navigation and tip location

Devices and methods obtain and use endovascular electrograms in a number of clinical applications and settings. In one embodiment, methods for triggering analysis of an endovascular ECG waveform are based on the detection of a peak in a skin-based ECG waveform in order to determine a location of an indwelling medical device, such as a catheter. In another embodiment, the position of a catheter or other medical device within the vasculature can be determined by analysis of the energy profile of a detected P-wave. In yet other embodiments, magnetic connecting devices are used for establishing an operable connection through a sterile field.

Apparatus and method for catheter navigation using endovascular energy mapping

Devices and methods obtain and use endovascular electrograms (or electrocardiograms/ECGs) in a number of clinical applications and settings. In one embodiment, a method for locating an indwelling medical device within a vasculature of a patient includes identifying a P-wave segment in an endovascular ECG signal associated with the indwelling medical device, then calculating a positive energy value relating to an amount of energy of the P-wave segment above a baseline of the endovascular ECG signal and a negative energy value relating to an amount of energy of the P-wave segment below a baseline of the endovascular ECG signal. A position of the medical device within the vasculature can be determined using at least one of the positive energy value and the negative energy value in a graphical user interface.

Apparatus and method for catheter navigation using endovascular energy mapping

Devices and methods obtain and use endovascular electrograms (or electrocardiograms/ECGs) in a number of clinical applications and settings. In one embodiment, a method for locating an indwelling medical device within a vasculature of a patient includes identifying an endovascular ECG waveform complex from an endovascular ECG signal associated with the indwelling medical device, then calculating an absolute value of the energy of the endovascular ECG waveform complex over a predetermined segment thereof. A position of the medical device within the vasculature is then determined by observation of the absolute value of the energy of the predetermined segment of the endovascular ECG waveform complex.

Apparatus and method for catheter navigation and tip location

Devices and methods obtain and use endovascular electrograms in a number of clinical applications and settings. In one embodiment, methods for triggering analysis of an endovascular ECG waveform are based on the detection of a peak in a skin-based ECG waveform in order to determine a location of an indwelling medical device, such as a catheter. In another embodiment, the position of a catheter or other medical device within the vasculature can be determined by analysis of the energy profile of a detected P-wave. In yet other embodiments, magnetic connecting devices are used for establishing an operable connection through a sterile field.

Devices and systems for navigation and positioning a central venous catheter within a patient

Devices and systems for navigation and positioning a central venous catheter within a patient. In an exemplary embodiment of a system of the present disclosure, the system comprises a first pole and a second pole, the first pole and the second pole configured to generate an electric field within a mammalian body sufficient to obtain a plurality of field measurements therein, and an elongated body configured for at least partial insertion into a blood vessel of the mammalian body and advancement through a vasculature, said advancement dependent upon the plurality of field measurements indicative of one or more locations of a portion of the elongated body within the vasculature. In at least one embodiment, the elongated body is configured as a stylet.

Method of locating the tip of a central venous catheter

Methods of locating a tip of a central venous catheter (“CVC”) relative to the superior vena cava, sino-atrial node, right atrium, and/or right ventricle using electrocardiogram data. The CVC includes at least one electrode. In particular embodiments, the CVC includes two or three pairs of electrodes. Further, depending upon the embodiment implemented, one or more electrodes may be attached to the patient's skin. The voltage across the electrodes is used to generate a P wave. A reference deflection value is determined for the P wave detected when the tip is within the proximal superior vena cava. Then, the tip is advanced and a new deflection value determined. A ratio of the new and reference deflection values is used to determine a tip location. The ratio may be used to instruct a user to advance or withdraw the tip.

电学和光学连接系统及光学连接系统

本申请涉及电学和光学连接系统及光学连接系统。一种电学和光学连接系统可包括具有插头的延伸管和具有插座的中继模块。所述插头可以由围绕电线的金属件形成，所述电线又围绕沿着所述延伸管的长度延伸的光纤芯。所述插头可以被配置为用于刺穿至少一个无菌屏障。所述中继模块可以包括所述中继模块的壳体内的电线和光纤芯、以及设置在所述壳体中的插座。所述插座可以被配置为在接受所述插头插入其中的同时在所述插头和所述插座之间建立从无菌区到非无菌区的电学连接和光学连接，所述无菌区和所述非无菌区由所述无菌屏障建立。还公开了包括所述光学连接系统的形状感测系统。

Malposition detection system

Disclosed herein is a system, apparatus and method directed to detecting malposition of a medical device within a vessel of a patient, such as an Azygos vein. The medical device can include a multi-core optical fiber including a plurality of core fibers, where each of the plurality of core fibers includes a plurality of sensors configured to reflect a light signal based on received incident light, and change a characteristic of the reflected light signal for use in determining a physical state of the multi-core optical fiber. The system can include a console having a non-transitory computer-readable medium storing logic that, when executed, causes operations of providing a broadband incident light signal to the multi-core optical fiber, receiving reflected light signals, processing the reflected light signals, and determining whether the medical device has entered the Azygos vein of the patient based on the reflected light signals.

Medical devices with a quick release drive connector

Disclosed herein, in some embodiments, are medical device systems including an elongate medical device having a proximal end including one or more sensor connectors, a distal end including one or more sensors or emitters communicatively coupled to the one or more sensor connectors, and a drive connector including one or more sensor connector attachments configured to detachably couple to the one or more sensor connectors. The one or more sensor connector attachments can be configured to drive the one or more sensors or emitters of the elongate medical device.

Apparatus, computer-aided data-processing algorithm, and computer storage medium for positioning an endovascular device in or near the heart

Aparato (100) para posicionar un dispositivo (110) endovascular en o cerca del corazón (400; 504; 604; 704) usando señales de electrocardiograma (ECG), que comprende un módulo (130; 250; 300) electrónico para llevar a cabo las etapas de: recibir una señal de ECG endovascular, asociada con el dispositivo endovascular, que incluye una pluralidad de formas de onda, teniendo cada forma de onda al menos una componente de onda P; caracterizado porque el aparato comprende además un módulo (140; 390) de ordenador para llevar a cabo las etapas de: procesar la señal de ECG endovascular, durante una pluralidad de periodos de tiempo predeterminados, para calcular una amplitud de onda P y una potencia espectral para cada periodo de tiempo predeterminado; determinar una amplitud de onda P máxima a partir de la pluralidad de amplitudes de onda P, y una potencia espectral máxima asociada a partir de la pluralidad de potencias espectrales; asociar la amplitud de onda P máxima y la potencia espectral máxima con una ubicación predeterminada en o cerca del corazón; calcular una ubicación del dispositivo endovascular, para cada periodo de tiempo predeterminado, basándose en una razón de la amplitud de onda P con respecto a la amplitud de onda P máxima y una razón de la potencia espectral con respecto a la potencia espectral máxima; y presentar visualmente la ubicación del dispositivo endovascular a un usuario. Apparatus (100) for positioning an endovascular device (110) in or near the heart (400; 504; 604; 704) using electrocardiogram (ECG) signals, comprising an electronic module (130; 250; 300) to perform the steps of: receiving an endovascular ECG signal, associated with the endovascular device, that includes a plurality of waveforms, each waveform having at least one P wave component; characterized in that the apparatus further comprises a computer module (140; 390) to carry out the steps of: processing the endovascular ECG signal, during a plurality of predetermined periods of time ...

Devices and methods for endovascular electrography

Connection system for establishing an electrical connection through a drape and methods thereof

A connection system includes a first connector and a second connector configured for establishing one or more electrical connections through a drape. The first connector can include an alignment protrusion and a first piercing element having one or more electrical contacts configured to pierce the drape. The second connector can include an alignment notch, a channel, and a first receptacle configured to receive the first piercing element when inserted therein. The alignment notch can be configured to accept the alignment protrusion when the first connector is aligned with the second connector then disposed over the second connector. The channel can be configured to allow the alignment protrusion to slide along a length of the second connector. The first receptacle can have one or more electrical contacts configured to form at least a first electrical connection of the one or more electrical connections with the first connector.

Connection systems and methods thereof for establishing electrical connections across a sterile field

Disclosed herein are connection systems for establishing electrical connections across a sterile field. An example connection system includes a sensor connector, a probe connector, and a tether having a first end connected to the sensor connector and a second end connected to the probe connector. The sensor connector includes a piercing element. The piercing element is configured to pierce a sterile side of a drape and establish a first electrical connection with a receptacle of a sensor when the piercing element is inserted into the receptacle. The probe connector includes a probe-connecting means configured for a user to establish a second electrical connection between an electrical contact of the probe connector and a wire probe. The tether is configured to convey electrical signals between the sensor connector and the probe connector. Also disclosed herein are methods of connection systems for establishing electrical connections across a sterile field.

Connection systems and methods thereof for establishing an electrical connection through a drape

利用ecg信号进行静态导管尖端确认的系统和方法

公开了利用ECG信号进行静态导管尖端确认的系统和方法。系统可以包括ivECG采集模块和通知模块，该ivECG采集模块用于从植入的血管内装置接收ECG数据。系统可以计算PxI和距离参数以确定植入的血管内装置的尖端相对于预定位置比如腔房结合部的位置。系统可以使用混沌理论和自组织临界性(SOC)的概念确定不存在P波或P波为非典型情况下的参数。通知模块可以包括音频信号、视频信号和触觉信号中的一个或多个。还公开了在先前定位的包括盐水柱和导电导丝的血管内装置内建立电气通路的系统和方法。

Optical connection systems and methods thereof

Optical connection systems including electrical-and-optical connection systems and methods thereof are disclosed. An electrical-and-optical connection system can include an extension tube having a plug and a relay module having a receptacle. The plug can be formed of a metal piece around electrical wires, which, in turn, are around optical-fiber cores that extend along a length of the extension tube. The plug can be configured to pierce through at least a sterile barrier. The relay module can include electrical wires and optical-fiber cores within a housing of the relay module, as well as a receptacle disposed in the housing. The receptacle can be configured to simultaneously accept insertion of the plug therein and establish both electrical and optical connections between the plug and the receptacle from a sterile field to a non-sterile field set up by the sterile barrier. Shape-sensing systems including the optical connection systems are also disclosed.

Apparatus and method for catheter navigation and tip location

Devices and methods for obtaining and using endovascular electrograms in a number of clinical applications and settings are disclosed. In one embodiment, methods are disclosed for triggering analysis of an endovascular ECG waveform based on the detection of a peak in a skin-based ECG waveform in order to determine a location of an indwelling medical device, such as a catheter. In another embodiment, the position of a catheter or other medical device within the vasculature can be determined by analysis of the energy profile of a detected P-wave. In yet other embodiments, magnetic connecting devices for establishing an operable connection through a sterile field are disclosed.

Implantable refillable infusion device

An implantable infusion device includes a lightweight, inert housing which contains an infusate for administration to a patient, and an enclosed, gas-impermeable variable volume chamber which contains a pressure source, such as propellant, mechanical spring, or the like. The variable volume chamber may be in the form of a rigid-walled expandable bellows structure or a nonstretchable flexible bag and is attached to the housing so as not to obstruct the entry port for introduction of infusate. The infusate is delivered from the device via a catheter in response to expansion of the variable volume chamber against the volume of infusate in the housing. A separate bolus injection port is provided which allows infusate to be safely introduced directly into the catheter and overrides the controlled pressure-driven delivery. The lightweight housing may include integrally formed needle stops and suture fastening loops.

Safety needle with collapsible sheath

The needle of a syringe, wire guide, biopsy needle, Huber needle and the like is drawn into a protective cap and sheath arrangement after use for disposal purposes. The cap is tethered to a housing in which the needle is mounted by the sheath. The sheath is made of a film material that has a high tensile strength and a low percent of elongation, such as polyester. The sheath is initially mounted about the needle in a collapsed accordion-like condition between the cap and housing. When the cap is moved along the needle, the sheath is played out over the needle. The cap houses a spring clip to snap over the bore through which the needle is retracted to prevent re-emergence of the needle. The flexible nature of the sheath allows the sheath to pass about the two legs of the Huber needle.

包括温度感测脉管装置的诊断系统和方法

诊断系统和方法，包括温度感测脉管装置。诊断系统可以包括用于在患者体内建立脉管或其他通路的导管组件。所述导管组件可以配备有一个或多个传感器，如温度传感器，当所述导管组件的一部分设置在所述患者体内时，所述一个或多个传感器能够监测所述患者的一个或多个生理方面，例如温度。所述导管组件可以被配置成将与所述生理方面相关的数据传输或以其他方式转发到另一个位置，例如控制台、智能手机或另一个移动设备、护士站、患者电子病历等。所述诊断系统的方法可以包括实例化步骤：在控制台的存储器中实例化诊断过程，所述诊断过程具有用于至少处理来自所述导管组件的温度数据的一个或多个功能。

使医疗装置磁化同时保持其无菌性的装置、系统及方法

本申请涉及使医疗装置磁化同时保持其无菌性的装置、系统及方法。例如，公开了一种用于在使医疗装置磁化的同时保持该医疗装置的无菌性的磁化器盖。该磁化器盖包括基座，从基座延伸的漏斗，以及从基座延伸的握持突片。基座包括医疗装置接口和与医疗装置接口相对的磁化器接口。漏斗包括漏斗杆，该漏斗杆配置为当细长医疗装置插入漏斗时保护细长医疗装置免于接触磁化器。握持突片配置用于操纵磁化器盖。

一种用于确认静态血管内装置的尖端位置的尖端确认系统

公开了一种用于确认静态血管内装置的尖端位置的尖端确认系统。系统可以包括ivECG采集模块和通知模块，该ivECG采集模块用于从植入的血管内装置接收ECG数据。系统可以计算PxI和距离参数以确定植入的血管内装置的尖端相对于预定位置比如腔房结合部的位置。系统可以使用混沌理论和自组织临界性(SOC)的概念确定不存在P波或P波为非典型情况下的参数。通知模块可以包括音频信号、视频信号和触觉信号中的一个或多个。还公开了在先前定位的包括盐水柱和导电导丝的血管内装置内建立电气通路的系统和方法。

用于建立电连接的安全装备连接系统及其方法

公开了一种连接系统及其方法便于穿过诸如消毒盖布的屏障建立电连接，而不损害由屏障建立的无菌区域。连接系统可以包含两个连接器。第一连接器可以包含限定空腔的第一连接器壳体、联接到第一连接器壳体的远端部分的可滑动端部件，以及连接到第一电导线的至少第一刺穿元件。该第一刺穿元件可以被配置为在该可滑动端部件朝向第一连接器壳体的近端部分前进时进入该空腔并且刺穿布置在该空腔中的屏障。第二连接器可以包含在连接到第二电导线的第二连接器壳体内的至少第一插座。该第一插座可以被配置为在该第一刺穿元件刺穿该屏障之后与该第一刺穿元件形成至少第一电连接。

Compositions and Methods for siRNA Inhibition of Angiogenesis

医疗设备系统及医疗设备插入系统

本申请涉及医疗设备系统及医疗设备插入系统。医疗设备系统包括细长医疗设备和驱动连接器，细长医疗设备具有近端、远端，近端包括一个或多个传感器连接器，远端包括通信联接至一个或多个传感器连接器的一个或多个传感器或发射器，驱动连接器包括一个或多个传感器连接器附接件，一个或多个传感器连接器附接件被配置为可拆分地联接至一个或多个传感器连接器。一个或多个传感器连接器附接件可以被配置为驱动细长医疗设备的一个或多个传感器或发射器。

骨内系统和骨内进入装置

骨内系统和骨内进入装置，其具有设置在无菌包装内的无菌进入组件。进入组件可以通过盖被密封在无菌包装内，该盖可以允许气体灭菌。无菌包装在操作和运输期间提供了机械保护和无菌屏障。在实施方案中，一次性骨内进入系统设置有预先附接至驱动器的进入组件和布置在其上的无菌包装或帽，该无菌包装或帽配置为在操作和运输期间提供机械保护和无菌屏障。在实施方案中，一旦帽被移除，进入组件从驱动器内的缩回位置延伸至展开位置。使用后，进入组件可以被缩回，以提供安全处置。系统可以进一步包括延伸器件，该延伸器件也布置在由驱动器或帽提供的无菌环境内。

光纤连接器模块和用于医疗装置的形状感测系统

本申请涉及光纤连接器模块和用于医疗装置的形状感测系统。在一个示例中，光纤连接器模块可以包括布置在壳体中的接收座、从壳体延伸的线缆和至少在线缆内的光纤。接收座可以被配置为接收第一插头的插入，用于在光纤连接器模块和医疗装置的光纤管心针之间建立第一光学连接。线缆可以包括第二插头，用于在光纤连接器模块和光学询问器之间建立第二光学连接。光纤通过线缆从接收座延伸至第二插头。光纤可以被配置为将输入光学信号从光学询问器传送至光纤管心针，并且将反射的光学信号从光纤管心针传送至光学询问器。还公开了包括光纤连接器模块的形状感测系统和前述各项的方法。

布拉格光栅光纤波动感测与监测系统

本文公开了涉及检测对医疗装置的光纤的损坏的系统、设备和方法。光纤包括芯纤维，其包括多个传感器，该多个传感器配置为：(i)基于接收的入射光，反射光信号；和(ii)基于经历的应变，改变反射光信号的特性。系统还包括具有存储器的控制台，该存储器存储当执行时引起如下操作的逻辑：由多个传感器中的一个或多个提供宽带入射光的不同光谱宽度的反射光信号的接收，处理反射光信号以检测光纤的一部分的波动，并且基于检测的波动确定光纤的一部分的位置或影响该部分被布置在其中的脉管的缺陷。部分可以是光纤的远侧尖端。

导管末端定位设备

提供一种基于计算机的方法，所述方法用于使用心电图(ECG)信号将血管内设备定位在心脏的内部或附近。所述基于计算机的方法包括：接收与血管内设备相关联的血管内ECG信号，在多个预定时间段期间对所述血管内ECG信号进行处理，以计算每个预定时间段内的P波幅值和谱功率，从所述多个P波幅值确定最大P波幅值，并且从所述多个谱功率确定相关联的最大谱功率，将所述最大P波幅值和所述最大谱功率与心脏内部或附近的预定位置相关联，在每个预定时间段内基于所述P波幅值与所述最大P波幅值的比率和所述谱功率与所述最大谱功率的比率来计算所述血管内设备的位置，以及向使用者显示所述血管内设备的位置。

System for cleaning and sanitizing

The present invention provides a system ( 10 ) for cleaning and sanitizing surfaces that incorporates a high pressure fluid supply ( 52 ) and a low pressure fluid supply ( 42 ), often carrying an ozonated fluid, and alternates directed streams of the two fluids for application to contaminated surfaces through a single applicator ( 70, 100 ).

COMPOSITION

Dynamically adjusted ultrasound imaging system and method thereof

本文公开了动态调整超声成像系统及其方法。例如，超声成像系统可以包括超声探头、控制台和显示屏。超声探头包括超声换能器阵列，当被激活时，超声换能器将生成的超声信号发射入患者，从患者接收反射超声信号，并且将反射超声信号转换为对应电信号以处理成超声图像。控制台被配置为执行指令，用于动态调整激活的超声换能器与预定目标或区域的距离、激活的超声换能器对预定目标或区域的取向、或激活的超声换能器相对于预定目标或区域的距离和取向二者。显示屏被配置为显示图形用户界面，该图形用户界面包括由控制台根据超声信号的对应电信号处理的超声图像。

Cysteine engineered antibodies and conjugates withCysteine engineered antibodies and conjugates with a free cysteine amino acid in the heavy chain a free cysteine amino acid in the heavy chain

Disclosed is a cysteine engineered antibody compriDisclosed is a cysteine engineered antibody comprising a free cysteine amino acid having a thiol reasing a free cysteine amino acid having a thiol reactivity value in the range of 0.6 to 1.0; and a sectivity value in the range of 0.6 to 1.0; and a sequence in the heavy chain selected from SEQ ID NOSquence in the heavy chain selected from SEQ ID NOS: 11, 12, 13, and 15: LVTVCSASTKGPS SEQ ID NO:11 : 11, 12, 13, and 15: LVTVCSASTKGPS SEQ ID NO:11 LVTVSCASTKGPS SEQ ID NO:12 LVTVSSCSTKGPS SEQ ID LVTVSCASTKGPS SEQ ID NO:12 LVTVSSCSTKGPS SEQ ID NO:13 HTFPCVLQSSGLYS SEQIDNO:15 where the cysteiNO:13 HTFPCVLQSSGLYS SEQIDNO:15 where the cysteine in SEQ ID NOS: 11, 12, 13, and 15 is the free cne in SEQ ID NOS: 11, 12, 13, and 15 is the free cysteine amino acid. Also disclosed are antibody-drysteine amino acid. Also disclosed are antibody-drug conjugate compounds with the cysteine engineereug conjugate compounds with the cysteine engineered antibody described above and a drug moiety selecd antibody described above and a drug moiety selected from a maytansinoid, an auristatin, a dolastatted from a maytansinoid, an auristatin, a dolastatin, and a calicheamicin. in, and a calicheamicin.

System and method for guiding a medical instrument

公开了一种用于辅助针插入到患者身体中的引导系统。所述引导系统使用超声成像或者其他适合的成像技术。在一个实施方案中，引导系统包括成像设备，所述成像设备包括探测器，用于产生内部身体部分目标（例如脉管）的图像。一个或更多个传感器与所述探测器一起被包括。传感器感测与所述针相关的可检测特征，例如与所述针一起被包括的磁体的磁场。系统包括处理器，所述处理器使用与感测特征相关的数据，来确定所述针的3-D位置。系统包括显示器，用于描绘所述针的位置。在其他实施方案中，用于引导刚性或者其他医疗器械的引导系统以及其各种示例性实施方式被公开。

Antimicrobial alginate-based microparticles and related materials and methods