Preparation and use of a su195m xxau-containing liquid

ABSTRACT OF THE DISCLOSURE A method for preparing a 195mAu-containing liquid is provided. In the method, 195mHg is adsorbed on an adsorption agent and then the daughter radioisotope 195mAu is eluted from the adsorption agent with an eluant containing a gold-complexing agent. The adsorption agent comprises a mercury ion-binding material having a substantially stronger adsorption affinity for mercury ions than for gold ions. Also disclosed are a radioisotope generator capable of producing a 195mAu-containing liquid and a process for conducting a radiodiagrostic examination on a warm-blooded animal using a 195mAu-containing liquid.

SOLUTION CONTAINING SELENOMETHIONINE-75 SE AND A THIOL AS A STABILIZER

L'invention concerne une solution de sélénométhionine-**75 Se contenant de la glycine de alpha -mercaptopropionyle ou de la glutathione comme stabilisateur. Ainsi, même après la stérilisation thermique usuelle, la pureté radio-chimique de la solution est maintenue plus longtemps à un niveau acceptable en pratique. Application : solution pour diagnostic. The invention relates to a selenomethionine - ** 75 Se solution containing alpha-mercaptopropionyl glycine or glutathione as a stabilizer. Thus, even after the usual thermal sterilization, the radio-chemical purity of the solution is maintained for a longer time at a level acceptable in practice. Application: solution for diagnosis.

AQUEOUS RADIOLOGICAL ASSAY SOLUTION FOR HOT BLOOD ANIMALS

SOLUTIONS UTILISABLES POUR LE DOSAGE RADIOLOGIQUE D'ANIMAUX A SANG CHAUD. CES SOLUTIONS SONT DES SOLUTIONS AQUEUSES D'UN CHELATE D'INDIUM RADIO-ACTIF ET D'UNE 8-HYDROXYQUINOLEINE, PRATIQUEMENT DEPOURVUES DE SOLVANT ORGANIQUE, D'ALCOOL OU DE CHLOROFORME PAR EXEMPLE. ELLES SONT UTILISABLES POUR REPERER DES INFECTIONS OU DES INFLAMMATIONS CHEZ LES ANIMAUX A SANG CHAUD.

Package for radiopharmaceutical compositions

Abstract of the Disclosure A package for radiopharmaceutical compositions is provided, which package consists essentially of a labelled glass vial around which a transparent holder is secured. Preferably, the trans-parent holder also has a label and is detachably secured to the composition-containing vial.

PACKAGING FOR RADIO-PHARMACEUTICAL PRODUCTS

LA PRESENTE INVENTION EST RELATIVE A UN EMBALLAGE POUR PRODUITS RADIO-PHARMACEUTIQUES ET A SON SUPPORT. L'EMBALLAGE EST CONSTITUE PAR UN FLACON OU UNE AMPOULE EN VERRE ETIQUETE AUTOUR DUQUEL EST FIXE, EVENTUELLEMENT DE FACON AMOVIBLE, UN SUPPORT TRANSPARENT. L'EMBALLAGE EST APPLICABLE AU STOCKAGE ET AU TRANSPORT DE PRODUITS CURATIFS OU DE DIAGNOSTIC RENFERMANT DES RADIO-ISOTOPES. THE PRESENT INVENTION RELATES TO A PACKAGING FOR RADIO-PHARMACEUTICAL PRODUCTS AND TO ITS SUPPORT. THE PACKAGING CONSTITUTES A LABELED GLASS BOTTLE OR BULB AROUND WHICH IS FIXED, POSSIBLY REMOVABLE, A TRANSPARENT SUPPORT. THE PACKAGING IS APPLICABLE TO THE STORAGE AND TRANSPORT OF CURATIVE OR DIAGNOSTIC PRODUCTS CONTAINING RADIO-ISOTOPES.

Patent FR2448528B1

Radioisotope generator

ABSTRACT OF THE DISCLOSURE Disclosed is a radioisotope generator (10) useful in the process of eluting a daughter radioisotope from an adsorbed parent radioisotope. The radioisotope generator (10) comprises a column (14) containing carrier material adapted to adsorb the parent radioisotope and including an inlet opening (16) and an outlet opening (20). The outlet opening (20) of the column (14) is connected to a tapping point (29) on the generator (10) by an eluate conduit (22), the tapping point adapted to receive an evauated elution vial so that a liquid eluate containing the daughter radioisotope can be obtained from the generator under vacuum. The generator (10) further includes a device (32) for interrupting the elution process before the elution vial is entirely filled while simultaneously exposing the generator to sterile air both in the direction of the generator column (14) and of the elution vial.

PACKAGING FOR RADIO PHARMACEUTICAL COMPOSITIONS

RADIO-ISOTOPE GENERATOR WITH MEANS FOR INTERRUPTING AN ELUTION PROCESS

GENERATEUR DE RADIO-ISOTOPE SERVANT A ELUER UN PRODUIT DE DESINTEGRATION RADIO-ISOTOPIQUE D'UNE TETE DE FAMILLE RADIO-ISOTOPIQUE ADSORBEE. LE GENERATEUR 10 COMPREND UNE COLONNE 14 CONTENANT UN MATERIAU PORTEUR CONCU POUR ADSORBER LA TETE DE FAMILLE RADIO-ACTIVE ET COMPORTANT UNE OUVERTURE D'ENTREE 16 ET UNE OUVERTURE DE SORTIE 20. L'OUVERTURE DE SORTIE SE RACCORDE A UN POINT DE PRELEVEMENT 29 PAR UN CONDUIT A ELUAT 22, LE POINT DE PRELEVEMENT ETANT DESTINE A RECEVOIR UNE FIOLE D'ELUTION MISE SOUS VIDE PERMETTANT DE RECUEILLIR UN ELUAT LIQUIDE CONTENANT LE PRODUIT DE DESINTEGRATION. LE GENERATEUR COMPORTE EGALEMENT UN DISPOSITIF 32 PERMETTANT D'INTERROMPRE LE PROCESSUS D'ELUTION AVANT QUE LA FIOLE D'ELUTION SOIT COMPLETEMENT REMPLIE, TOUT EN EXPOSANT SIMULTANEMENT LE GENERATEUR A DE L'AIR STERILE AUSSI BIEN DU COTE DE LA COLONNE QUE DU COTE DE LA FIOLE. LA SOLUTION DU PRODUIT DE DESINTEGRATION (LE TECHNETIUM 99M PAR EXEMPLE) PEUT ETRE UTILISEE POUR LE DIAGNOSTIC MEDICAL.

PRODUCTION OF RADIO-ISOTOPES

Selenomethionine-75se-containing solution,having a thiol as a stabilizer

Radiolabeled amine compounds and their use

Radiolabeled amine compounds, methods for preparing these compounds, diagnostic compositions containing the radiolabeled amine compounds and methods for using these compositions in conducting radiodiagnostic examinations for determining the location and extent of an occurring blood clot in the body of a warm-blooded animal such as a human. The radiolabeled amine compounds of the present invention have the general formula; (FORMULA) wherein X is selected from the group consisting of oxygen; sulfur; lower alkylene, radioactive selenium; and radioactive tellurium, Y is a hydrocarbyl amino group, and when X is oxygen, sulfur or lower alkylene, Y is a radioactive iodine-substituted hydrocarbyl amino group. Also disclosed are pharmaceutically-acceptable, acid addition salts of the above radiolabeled amine compounds.

Packages

Radioimmunological method of determining the thyroid function by an in vitro test in blood serum

SELENOMETIONIN-Ÿ75SE-CONTAINING SOLUTION WITH A TIOL AS A STABILIZER

Stabilized solution of selenomethionine

Homogenous radioimmunoassay with second addition of serum sample

HOMOGENOUS RADIOIMMUNOASSAY WITH SECOND ADDITION OF SERUM SAMPLE ABSTRACT OF THE DISCLOSURE Disclosed is an in vitro method of determining the thyroid function in blood serum. The method com-prises mixing a blood serum sample of a patient with a solution which contains radioactive thyroxine and with a compound which liberates thyroxine from thyroxine-binding globulin, buffering the mixture with a buffer-ing agent, adding another sample of the patient's blood serum in a quantity which is smaller than that of the initial blood serum sample, adding an antiserum con-taining antibodies for an immunoreaction with thyroxine, separating the non-bound thyroxine from the thyroxine bound to antibodies, and determining their relative quantities by measuring the radioactivity.

Vivo radioassay process

There is disclosed an in vivo radioassay process in which a radioactive chelate of indium and an 8-hydroxyquinoline is introduced into a warmblooded animal having an inflammatory reaction in an area in which the chelate would not accumulate to the same extent if the inflammation were not present. The chelate gathers in the inflamed area, for instance, in a body abscess, or other injury, and its location is determined by radio surveying the body by an external imaging technique.

Patent FR2454304B1

Radioimmunological method of determining the thyroid function

Radioimmunological method of determining the thyroid function by an in vitro test in blood serum

RADIOISOTOPE GENERATOR.

Radiolabeled amine compounds and their use

Shielding device for radio isotope generator

Selenomethionine-75 Se-containing solution having a thiol as a stabilizer

A selenomethionine- 75 Se-solution, which is suitable for use as a radioactive diagnostic material in medical science applications, is stabilized with regard to maintaining its radiochemical purity by the addition of a thiol of the formula HS--(CH.sub.2).sub.n --CHR--CO--NH--CH.sub.2 --COOH in which formula n is 0 or 1 and R is a methyl group when n is 0 and a glutamyl group when n is 1.

Patent FR2474314B1

RADIOISOTOPE GENERATOR

PREPARATION AND USE OF A? 72195M AU-CONTAINING LIQUID

SHIELDING DEVICE FOR A RADIOISOTOPE PRODUCER GENERATOR

RADIO AMMINAL COMPOUNDS MARKED PARTICULARLY USEFUL FOR DIAGNOSTIC PURPOSES AND PROCEDURE FOR THEIR PREPARATION AND USE

IN AN OUTER REMAINABLE PACKAGING FOR RADIOPHARMACEUTICAL PREPARATIONS

PROCESS FOR THE PREPARATION OF A RADIO-ISOTOPIC LIQUID FOR RADIOPHARMACEUTICAL APPLICATION OF A RADIO-ISOTOPE GENERATOR FOR IMPLEMENTING THE METHOD AND RESERVOIR FOR THE SAME

Method and device for preparing 195 mau contained liquid

Method of preparing a radioactive isotope-containing liquid, as well as device for generating said liquid

The invention relates to a method of preparing a radioactive isotope-containing liquid by allowing a solution of a radioactive parent isotope to pass through an adsorption agent in a column, the parent isotope being adsorbed on the adsorption agent and producing there a radioactive daughter isotope by decay, and by then eluting the daughter isotope from the adsorption agent with an eluent. The elution is carried out at elevated temperature. The invention also relates to a method of preparing a gold-195m-containing liquid by elution of an adsorption agent on which mercury-195m is adsorbed, which agent comprises at least two layers having different adsorption capacities for the parent isotope. The invention further relates to a device for generating a radioactive isotope-containing liquid, which device comprises a column with an adsorption agent, which column is provided with external heating means, to a generator column for said device, and to a method of preparing said generator column.

Generation of radio-isotopes

A method of preparing a liquid containing radioisotope for radiopharmaceutical application comprises eluting a radioactive daughter isotope from a parent isotope which is adsorbed on an adsorbent by means of a physiological solution, wherein a fission- produced parent isotope is used and the eluate comprising a daughter isotope is purified with a cation-exchange material. The method produces a liquid containing a radioisotope having an exceptionally high chemical, radiochemical and radionuclidic purity in a high yield. An isotope generator system suitable for use of the said method and a reservoir for said generator system is also described and claimed.

RADIO-ACTIVE MARKED AMINES AND THEIR USE

RADIOIMMUNOLOGICAL METHOD FOR DETERMINING THYROXIN IN BLOOD SERUM

Generatore di radioisotopi

Procedimento e sistema generatore per la preparazione di isotopi

Soluzione contenente selenomettionina-75 se, con un tiolo come stabilizzante.

Metodo per esaminare l'erogazione di sangue ai tessuti in un essere vivente a sangue caldo.

Procedimento e generatore di radio isotopi per la preparazione di un liquido contenente 195 m au

Procedimento di radio assaggio e composizione per l impiego in tale procedimento

Confezione per composizioni radio farmaceutiche

Composti amminici radio marcati particolarmente utili per scopi diagnostici e procedimento per la loro preparazione ed impiego

Dispositivo di schermatura per un generatore produttore di radioisotopi

Werkwijze voor de bereiding van radioactief seleno- methionine.

Dispositif pour l'examen de l'alimentation sanguine de tissus

DISPOSITIF UTILISABLE DANS L'EXAMEN DE L'IRRIGATION SANGUINE DES TISSUS DES ETRES A SANG CHAUD, COMPRENANT UN APPAREIL POUR LA PRODUCTION D'UN LIQUIDE CONTENANT UN RADIOELEMENT DE DEMI-VIE COURTE, UN MOYEN D'INJECTION DU RADIO-ELEMENT DANS LA CIRCULATION SANGUINE ET UN APPAREIL DE MESURE DE LA RADIOACTIVITE EN DIFFERENTS POINTS A L'EXTERIEUR DU CORPS; LE RADIOELEMENT EST NOTAMMENT AU.

Procede d'examen de l'alimentation sanguine de tissus dans un etre vivant a sang chaud

Metodo per esaminare l'erogazione di sangue ai tessuti in un essere vivente a sangue caldo

Beholder til faeces og femgangsmaade til opsamling af faeces tildiagnotisk undersoegelse

Shielding apparatus for a generator producing radio-isotopes

Beholder for fekalieproever.

Ricettacolo per la raccolta la con servazione e o l erogazione di campioni di feci a scopo diagnostico

Collecteur de matieres fecales et procede de collecte de matieres fecales en vue d'une determination diagnostique

Ontvanger voor faecalieen en werkwijze voor het opvangenvan faecalieen voor een diagnostische bepaling.

Un metodo de preparar derivados de metaloceno marcados con isotopos radiactivos.

Un metodo de preparar derivados de metaloceno marcados con isotopos radiactivos.

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE MATCLOCENO MARCADOS CON ISOTOPOS RADIACTIVOS, DE FORMULA (I), EN LA QUE MC ES UN METALOCENILO CON UN ATOMO CENTRAL RADIACTIVO; R Y R1 PUEDEN SER VARIOS RADICALES; Y N VALE 1-4.CONSISTE EN LA REACCION DE UN DERIVADO DE METALOCENO NO RADIACTIVO CON UN COMPUESTO METALICO RADIACTIVO, EN UN DISOLVENTE ORGANICO POLAR TAL COMO ETANOL O DIMETILFORMAMIDA, A TEMPERATURA ENTRE 30JC Y 250JC.ESTOS COMPUESTOS TIENEN APLICACIONES EN COMPOSICIONES PARA RADIODIAGNOSTICO, EN ESPECIAL EN EL EXAMEN DE LA FUNCION RENAL.

Radiolabelled metallocene derivatives