NONINVASIVE MULTI-PARAMETER PATIENT MONITOR

Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO”), fractional arterial oxygen saturation (“SpaO”), or the like. In an embodiment, the monitor advantageously includes a plurality of display modes enabling more parameter data to be displayed than the available physical display real estate. 1. A method of graphically displaying a plurality of physiological measurements on a single display , the method comprising:obtaining a first physiological measurement;obtaining a second physiological measurement;displaying an indication of the first physiological measurement on a first display area;displaying an indication of the second physiological measurement on the first display area, wherein the first display area alternates between displaying the indication of the first physiological measurement and the indication of the second physiological measurement;automatically switching between the indication of the first physiological measurement and the indication of the second physiological measurement without human intervention when a trend of either the first physiological measurement or the second physiological measurement indicate an alarm condition.2. The method of claim 1 , wherein the first physiological measurement is one of carbon monoxide saturation claim 1 , methemoglobin saturation claim 1 , total hemoglobin claim 1 , oxygen saturation claim 1 , and fractional oxygen saturation.3. The ...

NONINVASIVE MULTI-PARAMETER PATIENT MONITOR

Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO”), fractional arterial oxygen saturation (“SpaO”), or the like. The monitor can determine which a plurality of light emitting sources and which of a plurality of parameters to measure based on the signal quality and resources available. 1. A method of determining which of a plurality of physiological measurements to measure based on the signal quality of the signal , the method comprising:using a sensor configured to measure at least two different physiological measurements to obtain a signal from a light sensitive detector, the sensor including at least three different light emitters emitting at least three different wavelengths of light through tissue of a living patient and detecting the light after attenuation of the tissue;determining a signal quality of the signal;determining which of the at least two different physiological measurements are capable of being measured based on the signal quality determination; andactivating only enough of the at least three different light emitters necessary to obtain the measurements capable of being measured.2. The method of claim 1 , wherein if the signal quality is high claim 1 , all of the at least three different emitters are activated.3. The method of claim 1 , wherein if the signal quality is low claim 1 , only two of the at least three different emitters are activated.4. The method of ...

MULTI-STREAM SENSOR FOR NONINVASIVE MEASUREMENT OF BLOOD CONSTITUENTS

The present disclosure relates to a sensor having a set of photodetectors that are arranged at various locations to enable the measurement of blood glucose. The photodetectors are arranged across multiple locations. For example, the detector may comprise multiple photodetector arrays that are arranged to have a sufficient difference in mean path length to allow for noise cancellation and noise reduction. Walls may be used in the detector to separate individual photodetectors and prevent mixing of detected optical radiation between the different locations on the measurement site. A window may also be employed to facilitate the passing of optical radiation at various wavelengths for measuring glucose in the tissue. 1. A physiological sensor capable of outputting a signal responsive to a blood analyte present in a monitored patient , the sensor comprising:a sensor housing comprising an optical source configured to emit optical radiation on a body tissue of a medical patient;a heat sink associated with the sensor, the heat sink operative to receive thermal energy from the optical source and release thermal energy outside of the sensor housing; anda plurality of photodetectors each configured to detect the optical radiation from the optical source after attenuation by the body tissue of the medical patient and to output a signal responsive to the detected optical radiation, the signal reflecting one or more physiological parameters of the medical patient.2. The sensor of claim 1 , wherein the heat sink is at least partially exposed to air when the sensor is applied to the patient.3. The sensor of claim 1 , wherein the heat sink comprises a conductive shield of a medical cable claim 1 , the conductive shield being in electrical communication with a substrate claim 1 , the substrate being in electrical communication with the optical source.4. The sensor of claim 3 , further comprising an insulator connected to the substrate.5. The sensor of claim 1 , further comprising a ...

POPPET VALVE ASSEMBLY FOR CONTROLLING A PNEUMATIC ACTUATOR

A poppet valve assembly to control a pneumatic actuator may include a housing having a central bore. A first module may be disposed within the central bore, and the first module may have a first and second poppet valve. A second module may also be disposed within the central bore, and the second module may have a third and fourth poppet valve. A supply of pressurized fluid may be in fluid communication with a plurality of control valves such that pressurized fluid from the control valves opens and closes the poppet valves. The supply of pressurized fluid may also be in fluid communication with the first module and the second module such that the opening and closing of the poppet valves controls the position of the pneumatic actuator. 1. A poppet valve assembly comprising:a valve housing having a central bore;a first module disposed within the central bore, the first module comprising a first normally closed poppet valve and a second normally closed poppet valve, wherein each of the first and second normally closed poppet valves has an open position and a closed position;a central port formed in the first module, wherein the central port of the first module is adapted to be coupled to a first volume of a pneumatic cylinder;an exhaust port formed in the first module such that the central port is in fluid communication with the exhaust port when the first poppet valve is in the open position; anda supply port formed in the first module such that the central port is in fluid communication with the supply port when second poppet valve is in the open position,wherein the supply port is configured to be in fluid communication with a supply of pressurized fluid such that when the second poppet valve is in the open position, pressurized fluid is provided to the first volume of the pneumatic cylinder, andwherein the exhaust port is configured to vent pressurized fluid from the first volume of the pneumatic cylinder when the first poppet valve is in the open position.2. The ...

PATIENT MONITOR FOR MONITORING MICROCIRCULATION

A patient monitor capable of measuring microcirculation at a tissue site includes a light source, a beam splitter, a photodetector and a patient monitor. Light emitted from the light source is split into a reference arm and a sample arm. The light in the sample arm is directed at a tissue site, such as an eyelid. The reflected light from the tissue site is interfered with the light from the reference arm. The photodetector measures the interference of the light from both the sample arm and the reference arm. The patient monitor uses the measurements from the photodetector to calculate the oxygen saturation at the tissue site and monitor the microcirculation at the tissue site. 1. A method for monitoring microcirculation in a patient , the method comprising:emitting one or more beams of light from a light source;directing the one or more beams of light towards a tissue site of a patient using a beam splitter;detecting one or more beams of light reflected from the tissue site; andcalculating a flow of blood at the tissue site using the detected one or more beams of light.2. The method of claim 1 , wherein the flow of blood is calculated using multiple images of the tissue site.3. The method of claim 1 , wherein the flow of blood is calculated using at least one of ratios of oxygen saturation and ratios of a perfusion index.4. The method of claim 1 , wherein the tissue site is an eyelid.5. The method of claim 1 , further comprising calculating oxygen saturation and perfusion index of the tissue site.6. The method of claim 1 , further comprising splitting the one or more beams of light into one or more sample arm beams of light and one or more reference arm beams of light claim 1 , wherein at least one of the sample arm beams of light is directed towards the tissue site and the one or more reference arm beams of light is directed towards a reflector.7. The method of claim 6 , wherein optical interference between reflected one or more reference arm beams of light and ...

PEDIATRIC MONITOR SENSOR STEADY GAME

A monitoring device for measuring one or more physiological parameters of a medical patient can include a finger clip sensor connected to a monitor. An accelerometer in the finger clip sensor detects patient motion or movement that may interfere with monitoring. In response, the monitor displays a message alerting the patient to stop moving or a game in which the objective requires the patient to hold his or her finger still. The device can delay measurement until the patient is still enough and remains still long enough for a clear measurement. 1. A noninvasive medical monitoring device , the monitoring device comprising:a sensor having a housing comprising an upper shell and a lower shell pivotally connected together, the upper and lower shells each shaped to accept body tissue of a medical patient;one or more emitters disposed in the housing, the one or more emitters configured to impinge light on the body tissue of the patient;one or more detectors disposed in the housing, the one or more detectors configured to receive the light after attenuation by the body tissue of the patient and to output one or more intensity signals responsive to the attenuated light;a 3D accelerometer disposed in the housing, the 3D accelerometer configured to detect movement of the sensor and to output data related to the detected movement; and 'wherein the monitor comprises a display and content displayed on the display is based at least in part on output from said 3D accelerometer.', 'a monitor configured to receive output from said physiological sensor and said 3D accelerometer;'}2. The noninvasive medical monitoring device of wherein the sensor is connected to and communicates with the monitor via a cable.3. The noninvasive medical monitoring device of wherein the sensor is connected to and communicates with the monitor via a wireless connection.4. The noninvasive medical monitoring device of wherein content displayed on the display comprises one or more verbal messages.5. The ...

PERSONAL HEALTH DEVICE

An active pulse blood constituent monitor is disclosed. A sensor configured to provide an artificial excitation to a portion of the patient at a known frequency provides additional information in determining the physiological condition of the patient. 1. A system configured to determine one or more physiological parameters noninvasively using optical based techniques , the system comprising:one or more light emitting devices configured to emit light at one or more wavelengths;one or more detectors configured to detect light after absorption by body tissue;at least one motor configured to rotate at a known rate and generate a pulse wave in the body tissue at the measurement site, the pulse wave generated at a frequency higher than the frequency of the heart rate at least two harmonics of the heart rate and lower than about 50 Hz; anda processor configured to receive the detector signal and utilize information from both the natural heart rate pulse and the generated pulse wave to determine physiologically significant information regarding the status of the body tissue under measurement.2. The system of claim 1 , wherein the generated pulse wave does not affect the arterial pulse wave.3. The system of claim 1 , wherein a change in pressure in the body tissue caused by the generated pulse wave does not affect the natural heart rate pulse.4. The system of claim 3 , wherein the change in pressure caused by the natural heart rate pulse does not affect that generated pulse wave.5. The system of claim 1 , wherein the generated pulse wave has a frequency between about 8 Hz and about 12 Hz.6. The system of claim 5 , wherein the generated pulse wave has a frequency of about 8 Hz.7. The system of claim 5 , wherein the generated pulse wave has a frequency of about 12 Hz.8. A method of determining one or more physiological parameters noninvasively using optical based techniques claim 5 , the method comprising:emitting one or more wavelengths of light into a measurement site of a ...

PATIENT MONITORING SYSTEM

A patient monitoring system includes an inflatable cuff, a gas reservoir containing a compressed gas, and a sensor. When the inflatable cuff is coupled to a wearer, the gas reservoir supplies gas to the inflatable cuff to inflate the inflatable cuff via gas pathways. As the inflatable cuff inflates, a patient monitor can receive blood pressure data from the sensor and use the blood pressure data to determine the blood pressure of the wearer. The patient monitor can also receive blood pressure data during deflation of the inflatable cuff to determine the blood pressure of the wearer. 1. A blood pressure monitoring system wearable by a monitored patient , the system comprising:a housing;an inflatable cuff configured to encompass a limb of a monitored patient;a removable gas reservoir storing pressurized gas;a chamber positioning the gas reservoir;a gas pathway between the gas reservoir and the inflatable cuff operable to inflate and deflate the cuff using the pressurized gas;at least one sensor outputting a signal responsive to a pressure of the gas inside the cuff; anda processing device configured to receive said signal from said at least one sensor, process said signal and determine one or more blood pressure measurements during at least one of inflation and deflation;wherein said housing is operably associated with said chamber and said cuff to allow said blood pressure monitoring system to worn on said limb of said monitored patient.2. The system of claim 1 , wherein said processing device comprises a monitor and further comprising a housing operably associated with said processing device to allow said processing device to also be worn on said limb.3. The system of claim 1 , wherein said processing device comprises a personal computing device.4. The system of claim 1 , wherein said processing device comprises a phone executing one or more applications capable of said processing and said determining.5. The system of claim 1 , wherein said processing device ...

VALVE SIGNATURE DIAGNOSIS AND LEAK TEST DEVICE

A valve signature diagnosis and leak testing device includes a spool valve operatively connected to a pilot valve, the pilot valve being configured to position the spool valve to one of an open position and a closed position. A blocker valve is fluidly connected to a control fluid outlet of the spool valve. An electrical module is operatively connected to the pilot valve, a supply of control fluid, and the blocker valve, the electrical module being capable of sending pulsed electrical signals to the pilot valve and the blocker valve to selectively position the spool valve and the blocker valve to an open or closed position. 1. A valve signature diagnosis and leak testing device for a control valve , the valve signature diagnosis and leak testing device comprising:a spool valve operatively connected to a pilot valve, the pilot valve being configured to position the spool valve to one of an open position and a closed position, the spool valve including a first control fluid inlet, a first control fluid outlet, and a second control fluid outlet, the first control fluid inlet being fluidly connected to a supply of control fluid and the first control fluid outlet being configured to be connected to a valve actuator;a blocker valve fluidly connected to the second control fluid outlet; andan electrical module operatively connected to the pilot valve, the supply of control fluid, and the blocker valve, the electrical module being capable of sending pulsed electrical signals to the pilot valve and the blocker valve to selectively position the spool valve and the blocker valve to an open or a closed position,wherein the open position of the spool valve fluidly connects the first control fluid inlet to the first control fluid outlet and the closed position of the spool valve fluidly connects the first control fluid outlet to the second control fluid outlet.2. The valve signature diagnosis and leak testing device of claim 1 , wherein the electrical module includes a main ...

WIRELESS MONITORING AND CONTROL OF SAFETY STATIONS IN A PROCESS PLANT

A safety station for use in a process plant includes one or more leverless limit switches to detect activation of one or more parts of the safety station. The safety station further includes a wireless transmitter coupled to the leverless limit switches to transmit signals associated with the safety station to a base station device, which is communicatively coupled to one or more control and/or monitoring devices. 1. A safety station for use in a process plant , the safety station comprising:one or more leverless limit switches to detect activation of one or more parts of the safety station; anda wireless transmitter coupled to the leverless limit switches to transmit signals associated with the safety station to a base station device, wherein the base station device is communicatively coupled to one or more control and/or monitoring modules.2. The safety station of claim 1 , wherein the leverless limit switch is a GO® switch manufactured by the TopWorx corporation.3. The safety station of claim 1 , wherein the leverless limit switch remains latched until physically reset.4702. The safety station of claim 1 , wherein the wireless transmitter is the Rosemount dual input transmitter manufactured by the Emerson corporation.5. The safety station of claim 1 , wherein the wireless transmitter is an intrinsically safe wireless transmitter.6. The safety station of claim 1 , wherein the safety station is a safety shower and/or an eye wash station.7. The safety station of claim 1 , wherein at least one of the one or more control and/or monitoring stations is a remote touch screen panel.8. The safety station of claim 1 , wherein at least one of the one or more control and/or monitoring stations is a paperless recorder.9. The safety station of claim 1 , wherein at least one of the one or more control and/or monitoring stations is a workstation.10. A safety station monitoring and control system in a process plant claim 1 , the system comprising:one or more safety stations ...

Magnetic Reusable Sensor

A magnetic reusable sensor is configured to attach to a tissue site so as to illuminate the tissue site with optical radiation and detect the optical radiation after attenuation by pulsatile blood flow within the tissue site. The sensor is configured to communicate with a monitor so as to calculate a physiological parameter corresponding to constituents of the pulsatile blood flow determined by the detected optical radiation. The sensor has a reusable emitter and a detector. A disposable wrap removably secures the emitter and the detector to a tissue site via magnetically enhanced receptacles fixedly mounted on the wrap and magnetically enhanced carriers housing the emitter and the detector. 1. A magnetic reusable sensor is configured to attach to a tissue site so as to illuminate the tissue site with optical radiation and detect the optical radiation after attenuation by pulsatile blood flow within the tissue site , the sensor is configured to communicate with a monitor so as to calculate a physiological parameter corresponding to constituents of the pulsatile blood flow determined by the detected optical radiation , the sensor comprising:a reusable portion having at least one optical element;a disposable portion for removably securing the at least one optical element to a tissue site; andat least one magnet disposed on at least one of the reusable portion and the disposable portion so as to releasably join the reusable portion to the disposable portion.2. The magnetic reusable sensor according to wherein the disposable portion comprises a wrap strip configured to attach the at least one optical element to a fingertip.3. The magnetic reusable sensor according to wherein the disposable portion further comprises an optical element receptacle fixedly connected to the wrap strip and configured to removably join the at least one optical element to the wrap strip.4. The magnetic reusable sensor according to wherein the optical element receptacle comprises a first ...

SWITCH MODULE

A switch module used for position sensing may be operated in a number of modes for compatibility with a number of legacy position sensing products. A dry switch circuit can be configured to provide a direct output, emulating dry reed, high-side or low-side switched configurations. Alternatively, the dry switch circuit can be connected to an input of a NAMUR circuit to provide the known current output for that standard. In another configuration the dry switch can be selectively coupled to one of two NAMUR circuits allowing the switch module to provide a low-to-high current NAMUR output or a high-to-low current NAMUR output. 1. A switch module arranged and adapted to report a position of a moveable element external to the switch module , the switch module comprising:a first external connection, a second external connection, and a third external connection;a dry contact relay having a relay contact position responsive to a position of a component external to the switch module, the dry contact relay having a common connection, a normally open connection and a normally closed connection, where the normally open connection corresponds to a first position of the moveable element and the normally closed connection corresponding to a second position of the moveable;a NAMUR circuit having a first input connection pair and a first output connection pair;an electrical connection from the normally open connection of the dry relay to a first input of the first input connection pair of the NAMUR circuit;a selector operable to connect the common connection of the dry contact relay to i) a null contact of the selector or ii) a second input of the first input connection pair of the NAMUR circuit;a second electrical connection from the first output of the NAMUR circuit to one of the first external connection or the second external connection; anda third electrical connection between the second output of the NAMUR circuit to the third external connection;a first jumper that removeably ...

MULTIPLE MEASUREMENT MODE IN A PHYSIOLOGICAL SENSOR

In a physiological sensor that estimates a true parameter value by providing a predicted parameter value, multiple measurements are taken to increase the accuracy of the predicted parameter value. The sensor can be reapplied between measurements to decrease the probability of an erroneous prediction caused by sensor misplacement. Some measurements can be discarded before calculating a predicted parameter value. The physiological sensor can have a plurality of modes, with one of the modes corresponding to multiple measurement process. 1. A method of providing in a physiological sensor a predicted parameter value , the method comprising:obtaining a first set of measured input values from a physiological sensor; reapplying the physiological sensor, and', 'obtaining a set of measured input values;, 'obtaining one or more additional sets of measured input values from the physiological sensor, wherein obtaining each of said one or more additional sets of measured input values comprises'}calculating a predicted parameter value for each of the first and additional sets of measured input values;discarding one or more of the calculated predicted parameter values;determining, from the remaining predicted parameter values, a final predicted parameter value;providing an indication of the final predicted parameter value to a user.2. The method of wherein the discarded one or more predicted parameter values are selected based on the mean of the calculated predicted parameter values.3. The method of wherein the discarded one or more predicted parameter values are selected based on the median of the calculated predicted parameter values.4. A method of providing in a physiological sensor a predicted parameter value claim 1 , the method comprising:applying a physiological sensor configured to obtain one or more measured input values;obtaining a first measured input value;reapplying the physiological sensor;obtaining an additional measured input value;determining a final predicted ...

MODULATED PHYSIOLOGICAL SENSOR

A modulated physiological sensor is a noninvasive device responsive to a physiological reaction of a living being to an internal or external perturbation that propagates to a skin surface area. The modulated physiological sensor has a detector configured to generate a signal responsive to the physiological reaction. A modulator varies the coupling of the detector to the skin so as to at least intermittently maximize the detector signal. A monitor controls the modulator and receives an effectively amplified detector signal, which is processed to calculate a physiological parameter indicative of the physiological reaction. 1. A modulated physiological sensor is responsive to a physiological reaction of a living being to an internal or external perturbation that propagates to a surface area of the living being and is detected by a detector , the modulated physiological sensor comprising:a detector configured to communicate with a surface area of a living being so as to generate a signal responsive to a physiological reaction of the living being to a perturbation;a modulator that varies the coupling of the detector to the surface area so as to at least intermittently maximize the detector signal; anda monitor that controls the modulator and receives the detector signal so as to calculate a physiological parameter indicative of a physiological state of the living being.2. The modulated physiological sensor according to wherein the modulator is a vibration element that mechanically accentuates the coupling of the detector to the surface area.3. The modulated physiological sensor according to further comprising a substrate that co-mounts the detector and the vibration element.4. The modulated physiological sensor according to further comprising an attachment that releasably affixes the substrate claim 3 , detector and vibration element to the surface area.5. The modulated physiological sensor according to wherein the detector is an accelerometer.6. The modulated ...

Multiple wavelength sensor emitters

A physiological sensor has light emitting sources, each activated by addressing at least one row and at least one column of an electrical grid. The light emitting sources are capable of transmitting light of multiple wavelengths and a detector is responsive to the transmitted light after attenuation by body tissue.

Tissue profile wellness monitor

A tissue profile wellness monitor measures a physiological parameter, generates a tissue profile, defines limits and indicates when the tissue profile exceeds the defined limits. The physiological parameter is responsive to multiple wavelengths of optical radiation after attenuation by constituents of pulsatile blood flowing within a tissue site. The tissue profile is responsive to the physiological parameter. The limits are defined for at least a portion of the tissue profile.

CONFIGURABLE PATIENT MONITORING SYSTEM

A patient monitoring system can display one or more configurable health monitors on a configurable user interface. The health indicators are configured to display a physiological signal from a patient. The patient monitoring system can calculate ranges of values for the health indicator that correspond to a status of the patient. The health indicators can display different outputs based on the value of the physiological signal. 1. A patient monitoring system , comprising:at least one physiological sensor including a first and second light emitter and a detector, wherein the physiological sensor is configured to measure at least one physiological signal from a patient;at least one health indicator, wherein the health indicator is configured to display a signal value based upon the at least one physiological signal; receive patient information;', 'calculate a first range of values for the at least one health indicator based at least in part on the patient information, wherein the first range of values corresponds to a first range of physiological signals from the patient, wherein the first range of values corresponds to a first patient condition;', 'calculate a second range of values for the at least one health indicator based at least in part on the patient information, wherein the second range of values corresponds to a second range of physiological signals from the patient, wherein the second range of values corresponds to an second patient condition; and, 'a processorwherein the at least one health indicator is configured to display a first output when the signal value is within the first range of values; andwherein the at least one health indicator is configured to display a second output when the signal value is within the second range of values.2. The patient monitoring system of claim 1 , wherein the first patient condition is a healthy condition.3. The patient monitoring system of claim 1 , wherein the first patient condition is an unhealthy condition.4. The ...

MULTIPLE WAVELENGTH SENSOR DRIVERS

A physiological sensor has light sources arranged in one or more rows and one or more columns. Each light source is activated by addressing at least one row and at least one column. The light sources are capable of transmitting light of multiple wavelengths and a detector is responsive to the transmitted light after attenuation by body tissue. 1. A physiological sensor comprising:a plurality of light emitters comprising at least a first light emitter and a second light emitter;an electrical grid configured to activate one or more light emitters of the plurality of light emitters by addressing at least one row conductor and at least one column conductor, wherein each of the one or more light emitters comprises a first terminal and a second terminal;a first contact communicatively coupled with the first terminal of the first light emitter, the second terminal of the second light emitter, a first row conductor, and a first column conductor; anda second contact communicatively coupled with the second terminal of the first light emitter, the first terminal of the second light emitter, a second row conductor, and a second column conductor.2. A physiological sensor comprising:a plurality of light sources arranged in one or more rows and one or more columns, the plurality of light sources comprising at least a first light source and a second light source, wherein one or more light sources of the plurality of light sources are activated by addressing at least one row conductor and at least one column conductor, wherein each of the one or more light sources comprises a first contact and a second contact;a first electrical node communicatively coupled with the first contact of the first light source, the second contact of the second light source, a first row conductor, and a first column conductor; anda second electrical node communicatively coupled with the second contact of the first light source, the first contact of the second light source, a second row conductor, and a ...

CONTOURED PROTRUSION FOR IMPROVING SPECTROSCOPIC MEASUREMENT OF BLOOD CONSTITUENTS

A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector. 1. A noninvasive medical sensor configured to detect light attenuated by body tissue of a medical patient , the sensor comprising:a sensor housing comprising an upper shell and a lower shell pivotally connected together, the upper and lower shells each shaped to accept body tissue of a medical patient;one or more emitters disposed in the housing, the one or emitters configured to impinge light on the body tissue of the patient;one or more detectors disposed in the housing, the one or more detectors configured to receive the light after attenuation by the body tissue of the patient and to output one or more intensity signals responsive to the attenuated light; anda tissue thickness adjuster disposed in the housing, the tissue thickness adjuster positioned such that placement of the body tissue of the patient on the tissue thickness adjuster reduces a thickness of the body tissue and thereby increases a gain of the one or more intensity signals.2. The sensor of claim 1 , wherein the tissue thickness adjuster comprises a protrusion configured to deform the body tissue.3. The sensor of claim 2 , wherein the protrusion is a partially cylindrical protrusion.4. The sensor of claim 3 , wherein the partially cylindrical protrusion comprises a lens.5. The sensor of claim 4 , wherein the partially cylindrical protrusion ...

Systems and methods for determining blood oxygen saturation values using complex number encoding

The disclosure includes pulse oximetry systems and methods for determining point-by-point saturation values by encoding photoplethysmographs in the complex domain and processing the complex signals. The systems filter motion artifacts and other noise using a variety of techniques, including statistical analysis such as correlation, or phase filtering.

MULTI-WAVELENGTH PHYSIOLOGICAL MONITOR

A physiological monitor for determining blood oxygen saturation of a medical patient includes a sensor, a signal processor and a display. The sensor includes at least three light emitting diodes. Each light emitting diode is adapted to emit light of a different wavelength. The sensor also includes a detector, where the detector is adapted to receive light from the three light emitting diodes after being attenuated by tissue. The detector generates an output signal based at least in part upon the received light. The signal processor determines blood oxygen saturation based at least upon the output signal, and the display provides an indication of the blood oxygen saturation. 1. A physiological monitor for determining blood oxygen saturation of a patient , the physiological monitor comprising: three or more emitters, wherein each emitter is operative to emit light of a different wavelength; and', 'at least one detector adapted to receive light from the three or more emitters after being attenuated by tissue of a medical patient; and, 'a pulse oximetry sensor comprising compute a ratio based at least in part on three or more data signals, each of the three or more data signals indicative of light from one of the three or more emitters after being attenuated by the tissue, wherein the ratio comprises a quotient of a first weighted sum of the data signals multiplied by a first set of vector coefficients and a second weighted sum of the data signals multiplied by a second set of vector coefficients; and', 'determine blood oxygen saturation based at least in part upon a blood oxygen saturation curve using said ratio., 'a processor configured to2. The physiological monitor of claim 1 , wherein the first and second sets of vector coefficients are determined based upon calibration data or fitting of experimental data.3. The physiological monitor of claim 1 , wherein the at least one detector provides an output signal based at least in part on the received light and the ...

ADAPTIVE CALIBRATION SYSTEM FOR SPECTROPHOTOMETRIC MEASUREMENTS

This disclosure describes, among other features, systems and methods for customizing calibration curves, parameter algorithms, and the like to individual users. An initial calibration curve generated based on a population can be used as a starting point in an algorithm for measuring a physiological parameter such as glucose. The measurement algorithm can determine one or more initial measurement values for a user based on the initial calibration curve. In certain embodiments, one or more alternative measurements, such as invasive or minimally invasive measurements, can periodically or sporadically be input into the measurement algorithm. The algorithm can use the alternative measurements to adapt the calibration curve to the individual. As a result, measurements for the individual can more accurately reflect the individual's actual parameter values. 1. A method of determining whether to recommend an alternative measurement of a physiological parameter , the method comprising:obtaining a noninvasive measurement of a physiological parameter using an optical sensor;receiving an alternative measurement of the physiological parameter, the alternative measurement being generated by an alternative sensor;analyzing the noninvasive and alternative measurements by a processor to determine whether a condition has been met; andin response to the condition being met, outputting an indication that a new measurement should be obtained from the alternative sensor.2. The method of claim 1 , wherein analyzing the noninvasive and alternative measurements to determine whether a condition has been met comprises determining whether a difference between the noninvasive and alternative measurements exceeds a threshold.3. The method of claim 1 , wherein analyzing the noninvasive and alternative measurements to determine whether a condition has been met comprises determining a predetermined amount of time has passed.4. The method of claim 1 , wherein the indication comprises an alarm.5. The ...

OPTICAL SENSOR INCLUDING DISPOSABLE AND REUSABLE ELEMENTS

An embodiment of the present disclosure provides a noninvasive optical sensor or probe including disposable and reusable components. The assembly of the disposable and reusable components is straightforward, along with the disassembly thereof. During application to a measurement site, the assembled sensor is advantageously secured together while the componentry is advantageously properly positioned. 1. A disposable element of a noninvasive optical sensor , the disposable element configured to engage a plurality of tabs extending from a first casing of a reusable element , the disposable element comprising: a plurality of slots, wherein the slots are configured to receive the plurality of tabs upon assembly of the reusable and disposable elements, and', 'a plurality of holding elements, wherein the tabs slide away from the slots and under the holding elements upon application of the optical sensor around a measurement site due to tension on the first casing from a flexible circuit connected to the first casing, wherein the tabs sliding under the holding elements vertically fixes the first casing to the first clip; and, 'a first clip comprisingdisposable electronic components, wherein assembly of the reusable and disposable components electrically connects the disposable electronic components to reusable electronic components in the reusable element.2. The disposable element of claim 1 , wherein the disposable electronic components comprise an information element or memory device.3. The disposable element of claim 2 , wherein claim 2 , upon assembly of the reusable and disposable elements claim 2 , an electrical contact is made between the information element or memory device and the reusable electronic components in the reusable element.4. The disposable element of claim 1 , wherein the first clip further comprises a first electrical contact claim 1 , the disposable element further comprising a second clip claim 1 , the second clip comprising a second electrical ...

MAGNETIC-FLAP OPTICAL SENSOR

A magnetic-flap optical sensor has an emitter activated so as to transmit light into a fingertip inserted between an emitter pad and a detector pad. The sensor has a detector responsive to the transmitted light after attenuation by pulsatile blood flow within fingertip so as to generate a detector signal. Flaps extend from the emitter pad and along the sides of a detector shell housing the detector pad. Flap magnets are disposed on the flap ends and shell magnets are disposed on the detector shell sides. A spring urges the emitter shell and detector shell together, so as to squeeze the fingertip between its fingernail and its finger pad. The flap magnets have opposite north and south orientations from the shell magnets, urging the flaps to the detector shell sides and squeezing the fingertip sides. These spring and magnet squeezing forces occlude the fingertip blood flow and accentuate a detector signal responsive to an active pulsing of the fingertip. 1. A magnetic-flap optical sensor is configured to attach to a tissue site so as to illuminate the tissue site with optical radiation and detect the optical radiation after attenuation by pulsatile blood within the tissue site , the sensor having an active pulser so as to generate an artificial pulse and magnetic flaps so as to occlude blood flow at the tissue site , thereby accentuating the artificial pulse , the sensor adapted to communicate with a sensor processor so as to calculate a physiological parameter corresponding to constituents of the pulsatile blood , the sensor comprising:an emitter shell having an emitter;an emitter pad at least partially disposed within the emitter shell;a detector shell having a detector;a detector pad at least partially disposed within the detector shell;the emitter configured to transmit optical radiation into fingertip tissue inserted between the emitter pad and detector pad;the detector configured to receive the optical radiation after attenuation by pulsatile blood flow within ...

NON-INVASIVE MEASUREMENT OF ANALYTES

This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin. 1. A sensor composition comprising at least one small molecule metabolic reporter (SMMR) , wherein the composition is applied to at least one surface of living tissue , organs , interstitial fluid , and whole organisms and transported into the tissue at an effective concentration , wherein when the at least one small molecule metabolic reporter is brought in contact with one or more specific metabolites , a change in fluorescence or absorption of the at least one small molecule metabolic reporter occurs , thereby allowing quantification of the change in fluorescence or absorption , thereby providing detailed in vivo information regarding picomolar through millimolar levels of cellular metabolites and metabolic precursors in the living tissue , organs , interstitial fluid , and whole organisms.2. The sensor composition of claim 1 , wherein the at least one small molecule metabolic reporter is selected from the group consisting of a fluorophore claim 1 , a protein labeled fluorophore claim 1 , a protein comprising a photooxidizable cofactor claim 1 , a protein comprising another intercalated fluorophore claim 1 , a mitochondrial vital stain or dye claim 1 , and a dye exhibiting at least one of a redox potential claim 1 , a membrane localizing dye claim 1 , a dye with energy transfer properties claim 1 , a pH indicating dye claim 1 , a coumarin dye claim 1 , a derivative of a coumarin dye claim 1 , an anthraquinone dye; a cyanine dye claim 1 , an azo dye; a xanthene dye; an ...

MULTI-STREAM SENSOR FOR NONINVASIVE MEASUREMENT OF BLOOD CONSTITUENTS

The present disclosure relates to a sensor having a set of photodetectors that are arranged at various locations to enable the measurement of blood glucose. The photodetectors are arranged across multiple locations. For example, the detector may comprise multiple photodetector arrays that are arranged to have a sufficient difference in mean path length to allow for noise cancellation and noise reduction. Walls may be used in the detector to separate individual photodetectors and prevent mixing of detected optical radiation between the different locations on the measurement site. A window may also be employed to facilitate the passing of optical radiation at various wavelengths for measuring glucose in the tissue. 113-. (canceled)14. A physiological , noninvasive detector configured to detect optical radiation from a tissue site in order to measure physiological parameters of pulsating blood in living tissue , said detector comprising:a set of photodetectors that each provide a signal stream indicating optical radiation that has been transmitted through the tissue site from a plurality of emitters, wherein the set of photodetectors are arranged in a logarithmically spaced configuration that provides a variation in path lengths between at least some of the photodetectors; anda conversion processor that provides information indicating an analyte in the tissue site based on ratios of pairs of the signal streams.15. The detector of claim 14 , wherein the set of photodetectors are arranged in a row.16. The detector of claim 14 , wherein the set of photodetectors are contained in optically separate compartments.17. The detector of claim 14 , wherein the conversion processor comprises a set of transimpedance amplifiers that convert the signal streams from the set of photodetectors into a signal having a respective stream for each photodetector.18. The detector of claim 14 , wherein the conversion processor comprises a set of switched capacitor circuits configured to convert ...

SMMR (SMALL MOLECULE METABOLITE REPORTERS) FOR USE AS IN VIVO GLUCOSE BIOSENSORS

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin. 2. The reporter compound of claim 1 , wherein D is N or O.3. (canceled)4. (canceled)6. (canceled)7. A topical sensor composition comprising a compound of and a carrier or binder.9. (canceled)10. (canceled)11. The method of claim 8 , wherein said area of the body is skin.12. The method of claim 8 , wherein said area of the body is the layer of the skin known as stratum corneum.13. The method of claim 8 , wherein said area of the body is the layer of the skin known as epidermis.14. The method of claim 8 , wherein said area of the body is the layer of the skin known as dermis.15. The method of claim 8 , wherein said compound is glucose. This application is a continuation of U.S. application Ser. No. 13/215,061, filed Aug. 22, 2011, which is a continuation of U.S. application Ser. No. 10/584,821, filed Mar. 13, 2008 now U.S. Pat. No. 8,029,765, which is a U.S. national phase application under 35 U.S.C. §371 of International Application No. PCT/US2004/043087, filed Dec. 23, 2004, which claims priority under 35 U.S.C. §119(e) to Provisional Application Nos. 60/532,667, filed Dec. 24, 2003 and 60/571,170, filed May 14, 2004.This invention provides compositions and methods for designing small molecule metabolite reporters (SMMRs) for optical reporting of cell metabolism and intracellular or extracellular metabolite or analyte concentrations. The specific application of this work is to design molecules that are able to optically report the concentration of the biologically active molecule D-glucose, including other small molecule analytes or metabolic processes, in or near human keratinocytes located within the viable epidermis of human or mammalian skin. ...

Optical sensor including disposable and reusable elements

An embodiment of the present disclosure provides a noninvasive optical sensor or probe including disposable and reusable components. The assembly of the disposable and reusable components is straightforward, along with the disassembly thereof. During application to a measurement site, the assembled sensor is advantageously secured together while the componentry is advantageously properly positioned.

PHYSIOLOGICAL TEST CREDIT METHOD

A physiological test credit method determines if test credits are available to the monitor and checks if a Wi-Fi connection is available. If test credits are less than a test credit threshold, the monitor connects to a test credit server, processes server commands so as to download test credits and disconnects from the server. In various embodiments, the monitor is challenged to break a server code, the server is challenged to break a monitor code. The server validates monitor serial codes, and saves monitor configuration parameters. 1. A physiological test credit method programmatically initiates wireless communications between a physiological monitor and a remote server in response to available test credits falling below a predetermined threshold so as to download additional test credits from the server to the monitor and therefore enable the monitor to perform additional physiological parameter spot-checks on a per test credit basis , the physiological test credit method comprises:establishing a threshold for test credits stored in an optical sensor attached to a corresponding physiological monitor;securely connecting a server to the monitor when remaining test credits fall below the threshold; anddownloading test credits from the server to the monitor.2. The physiological test credit method according to further comprising:defining a quantum of test credits; anddownloading an amount of test credits equal to the quantum each time the remaining test credits fall below the threshold.3. The physiological test credit method according to further comprising:defining a download frequency according to the number of times remaining test credits fall below the threshold in a given period of time; andadjusting the threshold according to the download frequency.4. The physiological test credit method according to further comprising adjusting the quantum according to the download frequency.5. The physiological test credit method according further comprising adjusting the ...

NONINVASIVE MULTI-PARAMETER PATIENT MONITOR

Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO2”), fractional arterial oxygen saturation (“SpaO2”), or the like. In an embodiment, the monitor displays a line associated with a patient wellness level. 1. A method of comprising:processing one or more signals with one or more signal processors, said signals responsive to attenuation of light by body tissue of a monitored patient;noninvasively, electronically determining measured values of a plurality of physiological parameters including at least a first physiological parameter and a second physiological parameter, based at least in part on the processed one or more signals;providing an alarm threshold for the first physiological parameter;altering the alarm threshold for the first physiological parameter based at least in part on at least one measured value of the second physiological parameter satisfying threshold value; andactivating a caregiver alert based at least in part on at least one measured value of the first physiological parameter satisfying the altered alarm threshold.2. The method of claim 1 , wherein the caregiver alert comprises at least one of an LED activation claim 1 , an alarm message claim 1 , and an audible alarm.3. The method of claim 1 , wherein the caregiver alert changes as measured values of the first physiological parameter move further from the altered alarm threshold.4. The method of claim 1 , wherein ...

NONINVASIVE MULTI-PARAMETER PATIENT MONITOR

Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO”), fractional arterial oxygen saturation (“SpaO”), or the like. The monitor can determine which a plurality of light emitting sources and which of a plurality of parameters to measure based on the signal quality and resources available. 1. A method of determining which of a plurality of physiological measurements to measure based on the signal quality of the signal , the method comprising:using a sensor configured to measure at least two different physiological measurements to obtain a signal from a light sensitive detector, the sensor including at least three different light emitters emitting at least three different wavelengths of light through tissue of a living patient and detecting the light after attenuation of the tissue;determining a signal quality of the signal;determining which of the at least two different physiological measurements are capable of being measured based on the signal quality determination; andactivating only enough of the at least three different light emitters necessary to obtain the measurements capable of being measured.2. The method of claim 1 , wherein if the signal quality is high claim 1 , all of the at least three different emitters are activated.3. The method of claim 1 , wherein if the signal quality is low claim 1 , only two of the at least three different emitters are activated.4. The method of ...

Physiological parameter confidence measure

Confidence in a physiological parameter is measured from physiological data responsive to the intensity of multiple wavelengths of optical radiation after tissue attenuation. The physiological parameter is estimated based upon the physiological data. Reference data clusters are stored according to known values of the physiological parameter. At least one of the data clusters is selected according to the estimated physiological parameter. The confidence measure is determined from a comparison of the selected data clusters and the physiological data.

CONFIGURABLE PROCESS CONTROL DEVICE WITH ELECTRONIC DISPLAY ASSEMBLY

A configurable process control device, which includes a field device, such as a valve position controller, that can be configured by a user to emulate any one of a plurality of different types of process control devices, is provided with an electronic display assembly. The electronic display assembly is operatively connected with a control circuit that is arranged to respond to the specific configuration of the field device to cause the electronic display assembly to display information relevant to the specific type of control device the field device has been configured to emulate. The information may include safety certification information specific to each of the different types of process control devices that the field device can be configured to emulate. 1. A configurable process control device for use in a plurality of use environments , wherein at least one of a pre-defined plurality of certifications must be displayed in conjunction with the configurable process control device depending on which of the use environments the configurable process control device is to be used in , the configurable process control device comprising:a field device;a first control circuit operatively coupled to the field device, the first control circuit arranged to control the field device and arranged to be reconfigured by a user to allow the field device to selectively emulate any of a plurality of different process control device types;an electronic display assembly, the electronic display assembly arranged to selectively display different information; anda second control circuit, the second control circuit operatively coupled to the electronic display assembly and the first control circuit, the second control circuit having access to a plurality of different certification information sets, each certification information set corresponding to a different one of the plurality of different process control device types;wherein the second control circuit causes the electronic display ...

MULTI-STREAM SENSOR FRONT ENDS FOR NONINVASIVE MEASUREMENT OF BLOOD CONSTITUENTS

The present disclosure relates to an interface for a noninvasive glucose sensor that comprises a front-end adapted to receive an input signals from optical detectors and provide corresponding digital signals. In one embodiment, the front-end comprises switched capacitor circuits that are capable of handling multiple streams signals from the optical detectors. In another embodiment, the front-end comprises transimpedance amplifiers that are capable of handling multiple streams of input signals. In this embodiment, the transimpedance amplifier may be configured based on its own characteristics, such as its impedance, the impedance of the photodiodes to which it is coupled, and the number of photodiodes to which it is coupled. 1. A front-end interface for a noninvasive , physiological sensor , said front-end interface comprising:a set of inputs configured to receive signals from a plurality of detectors in the sensor;a set of switched capacitor circuits configured to convert the signals from the plurality of detectors into a digital output signal having a stream for each of the plurality of detectors; andan output configured to provide the digital output signal.2. The front-end interface of claim 1 , wherein the front-end interface is integrated with the sensor.3. The front-end interface of claim 1 , wherein the set of switched capacitor circuits are configured to combine the streams of a set of the detectors into a single stream.4. A conversion processor for a physiological claim 1 , noninvasive sensor claim 1 , said board comprising:a multi-stream input configured to receive signals from a plurality of detectors in the sensor, wherein the signals are responsive to optical radiation from a tissue site;a modulator that converts the multi-stream input into a digital bit-stream; anda signal processor that produces an output signal from the digital bit-stream.5. The conversion processor of claim 4 , wherein at least one of the detectors in the sensor comprise a set of ...

Patient monitoring system

A patient monitoring system includes an inflatable cuff, a gas reservoir containing a compressed gas, and a sensor. When the inflatable cuff is coupled to a wearer, the gas reservoir supplies gas to the inflatable cuff to inflate the inflatable cuff via gas pathways. As the inflatable cuff inflates, a patient monitor can receive blood pressure data from the sensor and use the blood pressure data to determine the blood pressure of the wearer. The patient monitor can also receive blood pressure data during deflation of the inflatable cuff to determine the blood pressure of the wearer.

Methods and devices for detecting intensity of light with translucent detector

An optical measurement device includes a light source, a first detector, and a second detector. The light source emits light to a measurement site of a patient and one or more detectors detect the light from the light source. At least a portion of a detector is translucent and the light passes through the translucent portion prior to reaching the measurement site. A detector receives the light after attenuation and/or reflection or refraction by the measurement site. A processor determines a light intensity of the light source, a light intensity through a tissue site, or a light intensity of reflected or refracted light based on light detected by the one or more detectors. The processor can estimate a concentration of an analyte at the measurement site or an absorption or reflection at the measurement site.

PIEZOELECTRIC LOUDSPEAKER

The present invention discloses a piezoelectric loudspeaker. The piezoelectric loudspeaker comprises a sound producing plate, a resonant sound-box, a surround and a reflective sound-box. The sound producing plate comprises a piezoelectric ceramic element. The resonant sound-box includes a first opening comprising a first carrying part. The sound producing plate is disposed on the first carrying part. A cavity resonator is formed between the sound producing plate and the resonant sound-box. The surround is disposed between the first carrying part and the sound producing plate. The reflective sound-box includes a second opening and a reflective output opening. The second opening comprises a second carrying part. The resonant sound-box is disposed on the second carrying part. A reflective cavity body is formed between the resonant sound-box and the reflective sound-box, and the reflective cavity body is connected the reflective output opening. 1. A piezoelectric loudspeaker , comprising:a sound producing plate including at least one piezoelectric ceramic element being able to vibrate the sound producing plate;a resonant sound-box including a first opening comprising a first carrying part, the sound producing plate being disposed on the first carrying part, and a cavity resonator being formed between the sound producing plate and the resonant sound-box;a surround disposed between the first carrying part and the sound producing plate; anda reflective sound-box including a second opening and a reflective output opening, a second carrying part formed on a partial of an inner edge of the seconding opening, the resonant sound-box being disposed on the second carrying part, a reflective cavity body being formed between the resonant sound-box and the reflective sound-box, the reflective output opening being disposed on a side of the reflective sound-box, and the reflective cavity body being communicating with the reflective output opening.2. The piezoelectric loudspeaker of ...

Pulse and active pulse spectraphotometry

A pulse and active pulse spectraphotometry system comprises a light source adapted to illuminate a tissue site with optical radiation having a plurality of wavelengths selected from at least one of a primary band of about 1620 nm to about 1730 nm and a secondary band of about 1000 nm to about 1380 nm.

SEPSIS MONITOR

Sensors are attached to a living being so as to generate corresponding sensor signals. A monitor is in communications with the sensors so as to derive physiological parameters responsive to the sensor signals. Predetermined limits are applied to the physiological parameters. At least one indicator responsive to the physiological parameters and the predetermined limits signal the onset of a sepsis condition in the living being. 1. A patient monitoring method seeking to identify a sepsis condition in said patient , said method comprising:noninvasively generating a plurality of sensor signals responsive to physiological parameters indicative of an onset of a sepsis condition in a said patient, at least one of said sensor signals responsive to the output of a noninvasive optical sensor;electronically computing measurements for said physiological parameters from the sensor signals, said parameters including at least oxygen saturations and respiration;applying a plurality of predetermined rules to the physiological parameters so as to determine the onset of the sepsis condition; andindicating to an observer the potential existence of the sepsis condition.2. The sepsis monitoring method according to wherein the generating comprises optically sensing constituents of pulsatile blood within the living being and acoustically sensing tracheal sounds of the living being.3. The sepsis monitoring method according to wherein the computing comprises deriving at least a pulse rate and a respiration rate.4. The sepsis monitoring method according to wherein the applying comprises determining if the pulse rate and the respiration rate are greater than a plurality of predetermined limits.5. The sepsis monitoring method according to wherein the indicating comprises activating a first colored light to indicate nonexistence of a sepsis condition and a second colored light to indicate a potential existence of a sepsis condition.6. The sepsis monitoring method according to further comprising ...

CONFIGURABLE PHYSIOLOGICAL MEASUREMENT SYSTEM

A physiological measurement system has a sensor, a processor, a communications link and information elements. The sensor is configured to transmit light having a plurality of wavelengths into a tissue site and to generate a sensor signal responsive to the transmitted light after tissue attenuation. The attenuated light can be used by the system to determine a plurality of physiological measurements. The processor is configured to operate on the sensor signal so as to derive at least one physiological parameter after which of the plurality of physiological measurements the system is configured to or capable of measuring. 1. (canceled)2. A physiological measurement system comprising:a plurality of components each configured to provide information specifying measurements the components are capable of supporting, at least one of the plurality of components being a sensor configured to transmit light having a plurality of wavelengths into a tissue site and to generate a sensor signal responsive to the transmitted light after tissue attenuation; anda processor configured to receive the information from each of the components and determine, based on the information, which of a plurality of potential physiological measurements the physiological measurement system is capable of supporting.3. The physiological measurement system of claim 2 , wherein the processor is further configured to calculate measurements of at least one of the plurality of potential measurements based on the determination.4. The physiological measurement system of claim 2 , wherein each of the plurality of components are further configured to provide characterization information.5. The physiological measurement system of claim 4 , wherein the characterization information comprises characterization information specific to respective components of the physiological measurement system.6. The physiological measurement system of claim 2 , wherein plurality of components further include at least one of a ...

Multi-stream data collection system for noninvasive measurement of blood constituents

The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

METHOD AND APPARATUS FOR REDUCING COUPLING BETWEEN SIGNALS IN A MEASUREMENT SYSTEM

A method and an apparatus for separating a composite signal into a plurality of signals is described. A signal processor receives a composite signal and separates a composite signal in to separate output signals. Pre-demodulation signal values are used to adjust the demodulation scheme. 1. A system which measures one or more physiological characteristics of a living subject non-invasively by measuring pulsing light of two or more wavelengths after attenuation by body tissue , the system comprising:at least one emitter configured to emit light of at least two or more different wavelengths using a modulation scheme that cycles the at least two or more different wavelengths, the at least one emitter positioned to emit light in the direction of a living subject;at least one detector configured to detect the light of the at least two or more different wavelengths emitted from the at least one detector after the light has been attenuated by tissue of the living subject, the detector further configured to generate a detector signal representative of the emitted light;a demodulation system configured to demodulate the detector signal, the demodulation system configured to adjust the demodulation of the detector signal to reduce crosstalk based, at least in part, on pre-demodulation signal values.2. The system of claim 1 , the demodulation system is further configured to adjust the demodulation based on previously demodulated signal values.3. The system of claim 1 , wherein the demodulation is adjusted during an initial calibration period.4. The system of claim 3 , wherein the demodulation is adjusted during periodic calibration periods during measurement.5. The system of claim 1 , wherein the demodulation system comprises a plurality of demodulation coefficients used to demodulate the detector signal.6. The system of claim 5 , wherein at least one demodulation coefficient is used for each of the at least two or more different wavelengths.7. The system of claim 2 , wherein ...

Multi-stream data collection system for noninvasive measurement of blood constituents

The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Noninvasive multi-parameter patient monitor

Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO2”), fractional arterial oxygen saturation (“SpaO2”), or the like. In an embodiment, the monitor displays a line associated with a patient wellness level.

Multi-stream data collection system for noninvasive measurement of blood constituents

The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Item Eligibility and/or Promotion Determination Application

In general, the present invention is directed to systems and methods of utilizing an application operating on a mobile device to determine any applicable offers or eligibility and rank such offers and eligibility for user selection. More specifically, a process may be conducted by a processor in communication with a mobile device and data stores including user data, retailer data, and/or product and service data, the process including comparing identification information associated with a product or service received from the mobile device with data in the data stores; determining the product or service and identifying any associated promotional offers or plan eligibility associated with the product or service, the user, and/or the retailer; ranking any promotional offers or plan eligibility based at least in part on size of promotion; transmitting to the mobile device an identifier of applicable promotional offers or plan eligibility. 1. A system , comprising:a processor; user data, including memberships, groups, plans, and/or entitlements associated with a user;', products and services offered by a retailer;', 'any promotional offers offered by the retailer;, 'retailer data, including, 'product and service data, including identification information of each product and service, and any promotional offers or plan eligibility associated with the product or service;, 'one or more data stores, the one or more data stores storing data comprisingwherein the processor is in selective communication with one or more retailers, manufacturers, membership plans, insurance providers, and/or entitlement providers to populate and update the one or more data stores;wherein the processor is in selective communication with a mobile device of the user; comparing first media data comprising identification information associated with a product or service received from the mobile device with product and service data stored in the one or more data stores;', 'based at least in part on the ...

Multi-stream data collection system for noninvasive measurement of blood constituents

The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

QUICK DISCONNECT CONNECTOR ASSEMBLY

A quick-disconnect connector assembly includes a housing having a bore that extends up to but not through a first end of the housing. The connector assembly also includes a proximity switch disposed within the bore, and the proximity switch includes a switch body, a first contact member, and a second contact member. A portion of each of the first and second contact members extends from the switch body towards a second end of the housing. In a first switch position, a contact of a displaceable switching assembly is in contact with the first contact member, and in a second switch position, the contact is in contact with the second contact member. The connector assembly also includes an external connection assembly including a first pin that is electrically coupled to the first contact member and a second pin that is electrically coupled to the second contact member. 1. A quick-disconnect connector assembly comprising:a housing that extends along a longitudinal axis from a first end to a longitudinally-opposite second end, the housing including one or more interior surfaces that cooperate to define a bore that extends from the second end to a point adjacent to the first end such that the bore does not extend through the first end of the housing, wherein the bore includes a first bore portion; a switch body extending along a body longitudinal axis, the switch body having a first end disposed adjacent to the first end of the housing and a longitudinally-opposite second end; and', 'a first contact member and a second contact member, each of the first and second contact members having a first end and a longitudinally-opposite second end, the second end being disposed within the switch body and the first end being disposed external to the switch body, wherein a portion of each of the first and second contact members extends from the second end of the switch body towards the second end of the housing,', 'wherein in a first switch position, a contact of a displaceable ...

PATIENT MONITOR PLACEMENT INDICATOR

A monitoring device for measuring one or more physiological parameters of a medical patient can include a finger clip sensor connected to a monitor. A placement indicator helps the patient to properly position the sensor. The monitor can display a message alerting the patient to reposition the sensor. The device can delay measurement until the sensor is properly positioned. 1. A noninvasive medical monitoring device , said monitoring device comprising:a physiological sensor configured to output at least one physiological signal; and [ calculate at least one reference transmittance value from said at least one physiological signal, wherein said at least one reference transmittance value is indicative of a reference position of said physiological sensor on a measurement site of a patient, and', 'calculate at least one operating transmittance value from said at least one physiological signal, wherein said at least one operating transmittance value is indicative of a position of said physiological sensor on said measurement site of said patient,;, 'a transmittance calculator configured to, 'a placement indication calculator configured to calculate a placement indication value based, at least in part, on said at least one reference transmittance value and said at least one operating transmittance value, wherein said placement indication value is indicative of said position of said physiological sensor on said measurement site relative to said reference position; and', 'a processing module configured to determine whether said placement indication value exceeds a placement indication threshold., 'a monitor comprising a display and a signal processing system comprising;'}2. The noninvasive medical monitoring device of claim 1 , wherein said processing module is further configured to generate an output on said display based at least in part on said placement indication value.3. The noninvasive medical monitoring device of claim 2 , wherein said output comprises one or more ...

CLOUD-BASED PHYSIOLOGICAL MONITORING SYSTEM

A cloud-based physiological monitoring system has a sensor in communications with a living being so as to generate a data stream generally responsive to a physiological condition of the living being. A monitor receives the data stream from the sensor and transmits the data stream to a cloud server. The cloud server processes the data stream so as to derive physiological parameters having values responsive to the physiological condition. The cloud server derives a medical index based upon a combination of the physiological parameters. The cloud server communicates the medical index to the monitor, which displays the medical index. 1. A cloud-based physiological monitoring system comprising:a sensor in communications with a living being so as to generate a data stream generally responsive to a physiological condition of the living being;a monitor that receives the data stream from the sensor and transmits the data stream to a cloud server;the cloud server processes the data stream so as to derive a plurality of parameters having values responsive to the physiological condition;the cloud server derives a medical index based upon a combination of the parameters;the cloud server communicates the medical index to the physiological monitor; andthe physiological monitor displays the medical index.2. The cloud-based physiological monitoring system according to wherein:the sensor comprises an optical sensor; andthe parameters comprise a blood constituent parameter.3. The cloud-based physiological monitoring system according to wherein the parameters further comprise a plethysmograph waveform parameter.4. The cloud-based physiological monitoring system according to further comprising:a blood pressure sensor in communications with the living being;a blood pressure monitor that receives a blood pressure data stream from the blood pressure sensor and transmits the blood pressure data stream to the cloud server;the cloud server processes the blood pressure data stream so as to ...

WIRELESS OPTICAL COMMUNICATION BETWEEN NONINVASIVE PHYSIOLOGICAL SENSORS AND PATIENT MONITORS

Embodiments of the disclosure include a noninvasive physiological patient sensor and a patient monitor capable of wireless communication with one another. An optical communication path can be used to provide the communication path between the noninvasive physiological patient sensor and the patient monitor. The path can be maintained by one or more light sources and detectors traditionally associated with noninvasive optical sensors or by one or more additional dedicated light sources and detectors. 1. A physiological monitoring system configured to process signals responsive to light attenuated by body tissue carrying pulsing blood , the system configured to determine measurement values for one or more physiological conditions of a patient being monitored , the system comprising: in response to receiving a sensor activation command, communicate a first drive signal to a light source of said noninvasive physiological sensor to irradiate tissue of a patient with light,', 'receive a detector signal output by a detector of said noninvasive physiological sensor responsive to detected light after attenuation by said tissue carrying pulsing blood, and', 'communicate a second drive signal to said light source of said noninvasive physiological sensor to transmit a communication signal responsive to said detector signal output by said detector of said noninvasive physiological sensor; and, 'a noninvasive physiological sensor comprising a processor configured to communicate said sensor activation command to said noninvasive physiological sensor,', 'receive a detector signal output by a detector of said patient monitor responsive to detected light transmitted by said noninvasive physiological sensor, said detector signal output by said detector of said patient monitor responsive to said communication signal,', 'determine measurement values of one or more physiological parameters of said patient based at least on said detector signal output by said detector of said patient ...

SYSTEMS AND METHODS FOR TESTING PATIENT MONITORS

A quality control system for patient monitors is disclosed. The quality control system can include a quality check insert having optical properties. In an embodiment, the insert is placed within a sensor, irradiated with light, and then the light is detected after attenuation by the insert. The detected light is processed using the same or different processing methodologies typically used to determine measurement values for physiological parameters of a monitored patient. When a patient monitor is functioning properly, the results of the processing provide values within a predetermined range of values. When the patient monitor is not functioning properly, the results of the processing provide values outside the predetermined range of values. The quality control system can include quality control parameters indicative of a properly functioning active pulse motor of the sensor, emitters of the sensor, detectors of the sensor, accelerometers of the sensors, and/or temperature sensors of the system. 1. A quality control system comprising:a noninvasive optical sensor configured to detect light attenuated by body tissue of a patient and output a detector signal responsive to the detected light;a patient monitor configured to process the detector signal to determine measurement values for one or more physiological parameters of the patient; andan insert shaped generally to mechanically mate with surfaces of the optical sensor, the insert having optical properties, wherein when the insert is properly placed within the sensor and irradiated by the sensor, the monitor processes detector signals, wherein the patient monitor provides display indicia indicative of whether the processed detector signals generate values within a predetermined range of values, the predetermined range associated with the optical properties of the insert.2. The quality control system of claim 1 , wherein the insert has at least one of a color indicator or a symbol indicator corresponding to ...

PATIENT MONITOR AS A MINIMALLY INVASIVE GLUCOMETER

In an embodiment, a patient monitor, such as a pulse oximeter, functions as a spot check glucometer when in communication with a blood glucose strip reader. In an embodiment, communications between the patient monitor and the strip reader may optionally be encrypted. Embodiments also include the strip reader housed in a dongle configured to mate with a sensor port of the pulse oximeter. 1. A spot check monitoring system using a monitor configured to accept signals responsive to light attenuated by body tissue comprising:a minimally invasive glucose reader; anda patient monitor in communication with said minimally invasive glucose reader,wherein, when a glucose level is read by said minimally invasive glucose reader, said glucose level is transmitted to said patient monitor,wherein said patient monitor is configurable as an oximeter and is configurable to display said glucose level when said glucose level is transmitted to said patient monitor.2. The spot check monitoring system of claim 1 , further comprising a dongle claim 1 , wherein said dongle houses said minimally invasive glucose reader.3. The spot check monitoring system of claim 1 , further comprising a reader board claim 1 , wherein said minimally invasive glucose reader is mounted on said reader board.4. The spot check monitoring system of claim 3 , further comprising an encryption controller configured to encrypt information from said minimally invasive glucose reader.5. The spot check monitoring system of claim 4 , further comprising an encryption board claim 4 , wherein said encryption controller is mounted on said encryption board.6. The spot check monitoring system of claim 5 , wherein said encryption board and said reader board are different boards.7. The spot check monitoring system of claim 1 , further comprising strips configured to be read by said minimally invasive glucose reader claim 1 , wherein said strips comprise source identifying strips.8. The spot check monitoring system of claim 1 , ...

Tissue profile wellness monitor

A tissue profile wellness monitor measures a physiological parameter, generates a tissue profile, defines limits and indicates when the tissue profile exceeds the defined limits. The physiological parameter is responsive to multiple wavelengths of optical radiation after attenuation by constituents of pulsatile blood flowing within a tissue site. The tissue profile is responsive to the physiological parameter. The limits are defined for at least a portion of the tissue profile.

Medical device management system

The present disclosure provides systems and methods for calibrating medical devices and processing physiological measurements using a medical device management system. As an example, the medical device can be a handheld glucometer configured for invasive testing and non-invasive testing of physiological parameters of a patient.

EMITTER DRIVER FOR NONINVASIVE PATIENT MONITOR

Embodiments of the present disclosure include an emitter driver configured to be capable of addressing substantially 2nodes with N cable conductors configured to carry activation instructions from a processor. In an embodiment, an address controller outputs an activation instruction to a latch decoder configured to supply switch controls to activate particular LEDs of a light source. 115-. (canceled)16. A cable configured to communicate signals between a patient monitor and a noninvasive optical sensor , the cable comprising:one or more signal lines configured to carry one or more drive signals to one or more optical radiation sources of the noninvasive optical sensor;N address lines configured to carry N address signals, N being greater than 2; and{'sup': N', 'N', 'N, 'a decoder comprising N input terminals and up to 2output terminals, the decoder configured to receive the N address signals from the N address lines via the N input terminals and to implement an addressing system capable of selectively individually addressing 2unique outputs based on the N address signals, the decoder configured to activate an output terminal of the up to 2output terminals based on the N address signals thereby activating the one or more optical radiation sources to provide optical radiation to tissue of the patient wearing the noninvasive optical sensor and allowing one or more photodetectors of the noninvasive optical sensor to detect the optical radiation after attenuation by the tissue.'}17. The cable of claim 16 , wherein the one or more signal lines comprise at least two signal lines configured to carry first and second drive signals claim 16 , one of the at least two signal lines configured to carry a different peak current level from the other of the at least two signal lines.18. The cable of claim 17 , wherein the one of the at least two signal lines is configured to electrically connect to a first group of the one or more optical radiation sources claim 17 , and the other ...

Physiological parameter confidence measure

Confidence in a physiological parameter is measured from physiological data responsive to the intensity of multiple wavelengths of optical radiation after tissue attenuation. The physiological parameter is estimated based upon the physiological data. Reference data clusters are stored according to known values of the physiological parameter. At least one of the data clusters is selected according to the estimated physiological parameter. The confidence measure is determined from a comparison of the selected data clusters and the physiological data.

Adjustable orthotic foot brace and method for adjusting a foot brace

The orthotic foot brace for a person wearing a footwear generally has: a lower leg holder securable to a lower leg of the person for use, a lower leg strut connected to the lower leg holder and extending downwardly towards the footwear during use; a foot strut structurally connected to the lower leg strut and having at least one side portion, each side portion extending forwardly along a respective side of the footwear and extending outwardly along a respective side of the footwear; an instep strut provided in the form of an extension of the foot strut along a long axis of the footwear, the instep strut having a distal portion securable to the footwear, and at least a proximal portion being slidably connected to the foot strut in a manner to allow adjusting the extension distance of the distal portion to a selected position.

Multi-stream data collection system for noninvasive measurement of blood constituents

The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Limb-worn patient monitoring device

The present disclosure describes example systems, methods, apparatuses, and medical devices for obtaining physiological parameter data from a wearable patient monitoring device. An example patient monitoring device can include an emitter and a detector. The emitter can emit light through tissue of a patient. The detector can sense the light after it passes through and is attenuated by the tissue and can generate a signal indicative of the sensed light. When the patient monitoring device is attached to or worn by the patient, the emitter and detector are aligned such that the light from the emitter travels through an opening between a first bone and a second bone of the patient prior to being sensed by the detector.

TRACEABLE METALLIC PRODUCTS AND METALLIC SUPPORT FOR NANOSTORAGE

The invention relates to traceable metallic products, methods of uses and methods of making same. The metallic products may be made traceable for integrity purposes, identification purposes, counterfeit avoidance and the like. The invention also relates to metallic supports for nanostorage of various compounds and samples. 1. A traceable metallic product , wherein said metallic product comprises a porous surface layer formed by anodization , and wherein said porous surface layer comprises at least one traceable biological compound.2. (canceled)3. The traceable metallic product of claim 1 , wherein said at least one traceable biological compound is selected from the group consisting of nucleic acids claim 1 , peptidic molecules claim 1 , lipids claim 1 , mono and polysaccharides claim 1 , hormones claim 1 , vitamins claim 1 , and derivatives thereof.4. (canceled)5. The traceable metallic product of claim 1 , wherein said at least one traceable biological compound is carried in nanopores of the porous surface layer claim 1 , and wherein said at least one traceable compound is recoverable from said porous surface layer for detection claim 1 , identification and/or utilization purposes.6. (canceled)7. The traceable metallic product of claim 1 , wherein said traceable metallic product consists of a metallic support for nanostorage of compound and samples.8. The traceable metallic product of claim 1 , wherein said porous surface layer is sealed.9. The traceable metallic product of claim 1 , wherein said porous surface layer further comprises an electrodeposit of at least one metal selected from the group consisting of silver claim 1 , gold claim 1 , copper claim 1 , nickel claim 1 , zinc claim 1 , tin claim 1 , cadmium claim 1 , palladium and platinum.10. The traceable metallic product of claim 1 , wherein said traceable metallic product consists of a traceable piece of aluminum comprising a porous surface layer formed by anodization claim 1 , and wherein said porous ...

VALVE SIGNATURE DIAGNOSIS AND LEAK TEST DEVICE

A valve signature diagnosis and leak testing device includes a spool valve operatively connected to a pilot valve, the pilot valve being configured to position the spool valve to one of an open position and a closed position. A blocker valve is fluidly connected to a control fluid outlet of the spool valve. An electrical module is operatively connected to the pilot valve, a supply of control fluid, and the blocker valve, the electrical module being capable of sending pulsed electrical signals to the pilot valve and the blocker valve to selectively position the spool valve and the blocker valve to an open or closed position.

Noninvasive multi-parameter patient monitor

Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO2”), fractional arterial oxygen saturation (“SpaO2”), or the like. In an embodiment, the monitor displays a line associated with a patient wellness level.

Compositions and Methods for siRNA Inhibition of Angiogenesis

System for cleaning and sanitizing

The present invention provides a system ( 10 ) for cleaning and sanitizing surfaces that incorporates a high pressure fluid supply ( 52 ) and a low pressure fluid supply ( 42 ), often carrying an ozonated fluid, and alternates directed streams of the two fluids for application to contaminated surfaces through a single applicator ( 70, 100 ).

COMPOSITION

Cysteine engineered antibodies and conjugates withCysteine engineered antibodies and conjugates with a free cysteine amino acid in the heavy chain a free cysteine amino acid in the heavy chain

Disclosed is a cysteine engineered antibody compriDisclosed is a cysteine engineered antibody comprising a free cysteine amino acid having a thiol reasing a free cysteine amino acid having a thiol reactivity value in the range of 0.6 to 1.0; and a sectivity value in the range of 0.6 to 1.0; and a sequence in the heavy chain selected from SEQ ID NOSquence in the heavy chain selected from SEQ ID NOS: 11, 12, 13, and 15: LVTVCSASTKGPS SEQ ID NO:11 : 11, 12, 13, and 15: LVTVCSASTKGPS SEQ ID NO:11 LVTVSCASTKGPS SEQ ID NO:12 LVTVSSCSTKGPS SEQ ID LVTVSCASTKGPS SEQ ID NO:12 LVTVSSCSTKGPS SEQ ID NO:13 HTFPCVLQSSGLYS SEQIDNO:15 where the cysteiNO:13 HTFPCVLQSSGLYS SEQIDNO:15 where the cysteine in SEQ ID NOS: 11, 12, 13, and 15 is the free cne in SEQ ID NOS: 11, 12, 13, and 15 is the free cysteine amino acid. Also disclosed are antibody-drysteine amino acid. Also disclosed are antibody-drug conjugate compounds with the cysteine engineereug conjugate compounds with the cysteine engineered antibody described above and a drug moiety selecd antibody described above and a drug moiety selected from a maytansinoid, an auristatin, a dolastatted from a maytansinoid, an auristatin, a dolastatin, and a calicheamicin. in, and a calicheamicin.

Systems and methods for calibrating minimally invasive and non-invasive physiological sensor devices

A calibration system is disclosed for calibrating a first physiological monitoring device using a second physiological monitoring device. The first physiological monitor measures a first indication of a physiological parameter. The second physiological monitor measures a second indication of the physiological parameter. The first and second indications are used to calibrate the first physiological monitoring device.

Physiological monitor calibration system

A calibration system is disclosed for calibrating a first physiological monitoring device using a second physiological monitoring device. The first physiological monitor measures a first indication of a physiological parameter. The second physiological monitor measures a second indication of the physiological parameter. The first and second indications are used to calibrate the first physiological monitoring device.

Solenoid actuated butterfly valve

A butterfly valve (100) and a valve system using the butterfly valve are disclosed. The butterfly valve includes a valve body (102) and a valve disk (112) disposed in the body such that the valve disk may be rotated between at least a first position and a second position using a linear actuator. The actuator may be a linear solenoid coupled to the valve disk spaced a distance from the axis of rotation of the valve disk.

Multivalent antibodies and uses therefor. Multivalent antibodies and uses thereof.

Multi-stream sensor front ends for noninvasive measurement of blood constituents

The present disclosure relates to an interface for a noninvasive glucose sensor that comprises a front-end adapted to receive an input signals from optical detectors and provide corresponding digital signals. In one embodiment, the front-end comprises switched capacitor circuits that are capable of handling multiple streams signals from the optical detectors. In another embodiment, the front-end comprises transimpedance amplifiers that are capable of handling multiple streams of input signals. In this embodiment, the transimpedance amplifier may be configured based on its own characteristics, such as its impedance, the impedance of the photodiodes to which it is coupled, and the number of photodiodes to which it is coupled.

Energy activated printing process

给出了反应性油墨和在基材上使用反应性且热激活的油墨产生图像的方法。在基材上印刷图像，而不使该油墨中的反应试剂反应。随后，使该反应试剂反应而将图像显著持久且牢固地固定到基材上。还将印刷的升华或类似热激活的染料印刷在该基材上。该升华或类似热激活的染料被激活，并且对施加到基材上的聚合物具有亲合性。

Method and apparatus for making insulating translucent panel assemblies

A method of making an insulating translucent panel assembly (10) such as a window or door lite is provided. In the method, a spacer (16) between two translucent panels (12) of glass or plastic includes a thermo- responsive sealing material (22). When heat and compression are applied to the spacer (16), the thermo-responsive sealing material (22) softens and fully seals the spacer (16) to the two translucent panels (12). A spacer (16) designed to be used in this method is also provided.

Patent DE4028660C2

Liquid flourescent dye concentrate for flow cytometry evaluation of virus-size particles and related products and methods

A kit, and method for flow cytometry include a liquid dye concentrate for fluorescent staining of virus-size particles with a plurality of fluorogenic dyes in a liquid medium. The liquid dye concentrate includes a plurality of fluorogenic dyes and one or both of (i) the liquid medium comprising a liquid mixture including water and liquid phase organic material and (ii) disaccharide dissolved in the liquid medium.

REUSABLE MAGNETIC SENSOR

Un capteur magnétique réutilisable est configuré pour se fixer sur un site tissulaire afin d'éclairer le site tissulaire avec le rayonnement optique et détecter le rayonnement optique après atténuation par le flux sanguin pulsatile à l'intérieur du site tissulaire. Le capteur est configuré pour communiquer avec un moniteur afin de calculer un paramètre physiologique correspondant aux constituants du flux sanguin pulsatile déterminé par le rayonnement optique détecté. Le capteur a un émetteur réutilisable et un détecteur. Une enveloppe jetable fixe de manière amovible l'émetteur et le détecteur sur un site tissulaire via des réceptacles magnétiquement améliorés montés de manière fixe sur l'enveloppe et des supports magnétiquement améliorés logeant l'émetteur et le détecteur. A reusable magnetic sensor is configured to attach to a tissue site to illuminate the tissue site with optical radiation and detect optical radiation after attenuation by pulsatile blood flow within the tissue site. The sensor is configured to communicate with a monitor to calculate a physiological parameter corresponding to the constituents of the pulsatile blood flow determined by the detected optical radiation. The sensor has a reusable transmitter and a detector. A disposable envelope removably secures the emitter and detector to a tissue site via magnetically enhanced receptacles fixedly mounted to the envelope and magnetically enhanced carriers housing the emitter and detector.

SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

Noninvasive sensor system with visual infographic display

A sensor system for obtaining and displaying information relating to physiological parameters, such as Total Hemoglobin and Pulse rate for use by a user such as an athlete. The system can present the measured physiological parameters to the user in a useful way. For example the system can display a visual multi quadrant infographic display, which can present the total hemoglobin values measured by the system in a particular season. The system can also display a visual elevation infographic display, which can present a comparison of the total hemoglobin values measured by the system over a period of time and/or at various altitudes. The system can also display a visual yin-yang infographic display, which can present a comparison of one or more metrics calculated by the system or one or more parameters measured by the system. The system can provide useful information about the user's health and/or well-being and allow the user to quickly and easily view and interpret relevant information.

Sensor comprising reusable portion and disposable portion releasably magnetically connected to each other

A magnetic reusable sensor is configured to attach to a tissue site to illuminate the tissue site with optical radiation and detect the optical radiation after attenuation by pulsatile blood flow within the tissue site. The sensor is configured to communicate with a monitor so as to calculate a physiological parameter corresponding to constituents of the pulsatile blood flow determined by the detected optical radiation. The sensor has a reusable emitter 600 and a detector 800. A disposable wrap strip 530 removably secures the emitter and the detector to a tissue site. The reusable portion magnetically attaches to the disposable portion via magnetically enhanced receptacles fixedly mounted on the wrap and magnetically enhanced carriers housing the emitter and the detector. Also disclosed is a sensor comprising a fixed portion and a removable portion which magnetically attach to each other, and wherein the removable sensor portion comprises a memory element electrically connected to a reader in a sensor processor via a conductor in a connector disposed on the fixed sensor portion. A plurality of mounts may be disposed on the fixed and removable sensor portions and a conductive coil may be disposed around at least one of the mounts so as to release the mounts when the coil is electrically activated.

Method of constructing and executing a process

Disclosed is a method of constructing and executing a process. A conventional process is minutely divided into minimum unit subprocesses, and the minutely divided subprocesses are classified into a decision subprocesses and a routine subprocess by whether they require decision-making. Any subprocess which is executable using the setup condition in a specific decision subprocess is classified into the routine subprocess in such a manner that the classified routine subprocess follows on the specific decision subprocess. One or a series of decision subprocesses are combined with one or a series of routine subprocesses which are executable on the condition of the completion of the decision subprocesses to form one unit process, and a job-support computer program is created to allow the plurality of subprocesses included in the one unit process to be successively executed. A plurality of subprocesses which are executable in accordance with common input data are detected from the minutely divided minimum unit subprocesses, and a job flow is constructed to allow the respective jobs in the plurality of subprocesses to be simultaneously initiated and executed in parallel. The present invention can drastically reduce the lead-time of a process while facilitating execution of the entire process with high efficiency.

Enclosed proximity switch assembly

An enclosed proximity switch assembly includes a top enclosure and a bottom enclosure that are coupled to form an interior volume. A shaft protrusion upwardly extends from a top surface of the top enclosure, and an interior bore portion having an enclosed volume is defined within the shaft protrusion to form a portion of the interior volume. A first end of a vertical shaft is rotatably disposed within the interior bore portion such that the shaft rotates relative to the top and bottom enclosures. A samarium cobalt target magnet is coupled to the shaft, and the target magnet interacts with a samarium cobalt driver magnet within a proximity switch when the target magnet is rotated within a predetermined distance of a top portion of the proximity switch. The interaction causes a switch to move from a first state to a second state, or vice versa.

Physiological test credit method

A physiological test credit method determines if test credits are available to the monitor and checks if a Wi-Fi connection is available. If test credits are less than a test credit threshold, the monitor connects to a test credit server, processes server commands so as to download test credits and disconnects from the server. In various embodiments, the monitor is challenged to break a server code, the server is challenged to break a monitor code. The server validates monitor serial codes, and saves monitor configuration parameters.

Component of printed circuit boards

A component (10) for use in manufacturing articles, such as printed circuit boards, comprising a laminate constructed of a sheet of copper foil (20) that, in a finished circuit board, constitutes a functional element, and a sheet of carbon steel (14) having a layer of an inert metal (16) thereon, the sheet of carbon steel (14) constituting a discardable element. One surface (22) of the copper sheet (20) and the surface (18) of the inert metal layer (16) on the carbon steel sheet (14) are essentially uncontaminated and engageable with each other at interfaces. The copper sheet (20) is attached to the inner metal layer (16) of the carbon steel (14) at their borders and defines substantially uncontaminated central zones inwardly of the edges of the sheets that are unjoined at the interfaces.

Multi-stream sensor front ends for noninvasive measurement of blood constituents

The present disclosure relates to an interface for a noninvasive glucose sensor that comprises a front-end adapted to receive an input signals from optical detectors and provide corresponding digital signals. In one embodiment, the front-end comprises switched capacitor circuits that are capable of handling multiple streams signals from the optical detectors. In another embodiment, the front-end comprises transimpedance amplifiers that are capable of handling multiple streams of input signals. In this embodiment, the transimpedance amplifier may be configured based on its own characteristics, such as its impedance, the impedance of the photodiodes to which it is coupled, and the number of photodiodes to which it is coupled.

Data generating device, data generating method and data generating program

Systems and methods for providing, reloading, and redeeming stored value cards used in transit applications

The invention is directed to systems and methods of conducting transactions associated with a transit card. A method of conducting transactions may be conducted between a processor and a transit processor. Steps may include receiving a redemption request and determining if it is a pre-authorization request or a redemption; if the redemption request is a pre-authorization request, determining if the account is authorized for a particular transit type. If the account is authorized, communicating approval to the transit processor. If the account is not authorized communicating denial. If the redemption request is a redemption: determining if account value is sufficient to pay the redemption amount; if not, denying and if so approving the transaction and deducting the amount, and determining if the account value is below a pre-determined threshold for a particular transit types, and if so, updating the status of the account at a data store.

Dual/variable gain oil pump control valve

A solenoid fluid control valve is disclosed for controlling a variable displacement pump. The solenoid fluid control valve comprises a fixed solenoid component (702), a movable armature component (710), a fixed nozzle body (722), a movable spool (720) within the fixed nozzle body, and a valve member (714). The valve member regulates fluid pressure in a first (746, 748) and second feedback chamber. Fluid in the second feedback chamber establishes a second feedback pressure that acts on the movable spool with a motive feedback force in a first axial direction. The movable spool moves in the first axial direction in response to the motive feedback force.

System for monitoring a physiological parameter of a user

The present disclosure provides an electronic device that includes at least one sensor indicative of a physiological condition of a user, the at least one sensor worn by a patient. The electronic device can further include a location determination module configured to determine a location of a patient. The electronic device can receive a measured information from the sensor and determine if the physiological condition of the user indicates an urgent medical need. When the physiological condition of the user indicates an urgent medical need, the electronic device can contact emergency services and access and contact one or more of a contact in an electronic address book associated with the processing system. The electronic device can provide a location of the user based on information determined by the location determination module.

Indicator compounds, devices comprising indicator compounds, and methods of making and using the same

Some embodiments disclosed herein pertain to indicator compounds used to detect the presence of and/or an amount of an analyte. In some embodiments, the indicator compounds are fusion proteins. In some embodiments, when the analyte binds to the indicator compound, the indicator compound undergoes a conformational change. In some embodiments, the conformational change results in a luminescent signal that allows quantification of the amount of analyte present.

A kind of industrial waste gas dust treatment device

本实用新型公开了一种工业废气粉尘处理装置，包括壳体，所述壳体内壁的顶部对称设置有第一支撑柱，两个第一支撑柱的底部通过第一吸尘管固定连接，所述壳体顶部的中点处固定连接有吸尘风机，所述吸尘风机的底部从上至下依次贯穿壳体和第一吸尘管且延伸至第一吸尘管的内部。本实用新型通过壳体、第一吸尘管、吸尘风机、过滤水箱、第二吸尘管、第三吸尘管、冲刷水箱、第一水管、冲刷喷头、旋转电机、旋转转轴、滚筒、海绵吸附棒、活性炭吸附层、过滤板、出水口、循环水池、循环水泵、第三水管和第四水管相互配合，起到了防逸散的效果，能够有效去除废气中的粉尘，保护了工作人员的身体健康，提高了工作人员的工作积极性。

Implantable micro-electrochemical cell

A disease management system including an microelectrochemical cell configured to be implanted into a patient. The microelectrochemical cell may include a tube which may include at least one sidewall, a closed end configured to be implanted in the patient, and open end configured to receive a feedthrough for at least one electrode lead. The microelectrochemical cell may further include a fluid medium in fluid communication with bodily fluid, an analyte sensor configured to measure at least one analyte within the bodily fluid, and at least one electrical connection to the analyte sensor at the feedthrough.

Solenoid actuated butterfly valve

A butterfly valve (100) and a valve system using the butterfly valve are disclosed. The butterfly valve includes a valve body (102) and a valve disk (112) disposed in the body such that the valve disk may be rotated between at least a first position and a second position using a linear actuator. The actuator may be a linear solenoid coupled to the valve disk spaced a distance from the axis of rotation of the valve disk.

Trans-septal cardiac occluder device

本发明涉及一种可穿越间隔心脏封堵器装置(1)，包括：·‑支撑结构(2)；其中·‑所述支撑结构(2)包括界定内腔(4)的中心支撑结构部分(3)；·‑所述支撑结构(2)包括第一锚固部分(5)和相对的第二锚固部分(6)；·‑所述支撑结构(2)被配置成在用于通过患者的脉管系统插入的压缩管状配置与扩张或延伸配置之间扩张和收缩，在扩张或延伸配置中所述第一和第二锚固部分(5，6)从所述中心支撑结构部分(3)径向向外延伸以通过以下来压缩其间的间隔(7)：通过存在于所述间隔(7)中的缺损或孔或开口将所述支撑结构(2)布置成跨在所述间隔(7)上；并且其中·‑所述可穿越间隔心脏封堵器装置(1)进一步包括至少一个隔离件(8)；·‑所述隔离件(8)由所述支撑结构(2)支撑并且被布置成当所述隔离件(8)处于其中所述支撑结构(2)被延伸的松弛配置时闭合所述内腔(4)的大部分；·‑所述隔离件(8)被配置成允许插入到由所述间隔(7)界定的第一区室(9或10)中的医疗仪器穿过所述隔离件(8)，以及然后穿过所述内腔(4)进入由所述间隔(7)界定的第二区室(10或9)；其中·‑所述隔离件(8)包括多个长型膜封堵条状物或桥(21)或封堵桥(21)；·‑所述封堵桥(21)的每个包括长型本体(50)，所述长型本体具有相对的长型本体端部或端部(51，52)和相对的纵向边缘或边(22)；·‑在所述隔离件(8)的松弛配置中，所述多个封堵桥(21)中的每个封堵桥(21)被布置成接近于所述多个封堵桥(21)中的至少另一个封堵桥(21)；·‑每个封堵桥(21)的所述纵向边(22)的至少一部分和所述至少另一个封堵桥(21)的所述纵向边(22)的至少一部分界定在所述隔离件(8)上的至少一个狭缝或一个切口(27)；·‑每个封堵桥(21)的两个所述相对的端部(51，52)直接或间接地连接到所述支撑结构(2)上或由所述支撑结构(2)支撑。

Automated method for direct sampling of immune cells from whole blood or other biological samples in microwell plates

A method for automatic sampling of immune cells from a biological fluid sample, e.g., whole blood, deposited in a well of a microwell plate. The sample contains red blood cells (RBCs) and magnetic beads which are designed to bind to the RBCs. The microwell plate is placed on a shaker having a magnetic adapter including at least one magnet. The magnet causes the RBCs bound to the magnetic beads to be attracted to and migrate to a wall of the well (e.g., the bottom or side wall) and be held against the wall. The shaker is then operated to shake the microwell plate in a manner and for a time period so as to suspend substantially evenly or homogeneously the immune cells in the biological fluid sample within a region of the well but still retain the holding of the RBCs to the wall of the well such that the immune cells are substantially isolated from the RBCs in the region of the well. During or after shaking, a sample probe is then lowered into the region of the well to withdraw a portion of the sample containing the immune cells.

Passive reduction or elimination of frost and fog

Lens fogging or frosting on inside surfaces of an instrument lens may be reduced or prevented by sealing the instrument housing. Damage or rupture of the sealed housing due to an increase or decrease in pressure within the housing may be avoided while reducing introduction of moisture into the housing by venting the housing through a tube to a location having a relatively lower humidity.

Glucose sensors and methods of manufacturing

Embodiments of the present disclosure relate to a temperature independent glucose sensor and methods of making the same. Such glucose monitoring device may comprise a working electrode, a reference electrode, an glucose oxidase containing enzymatic layer, a first permeability-selective layer, an oxygen-replenishing layer, and an outer protective layer. Additional embodiments relate to a glucose sensor having an enzymatic layer containing glucose oxidase and a polymeric mediator. The sensors may be used as an implantable continuous glucose monitoring device without the need of a temperature sensor.

Method of securing optical fiber components, devices and fibers to the same or to mounting fixtures

A method of bonding glass-based optical elements comprising the steps of positioning a first glass-based optical element relative to a second glass-based optical element, applying a glass-based bonding compound about the first and second optical elements, and applying sufficient localized heat to the glass-based bonding compound to cause the glass-based bonding compound to soften and fuse with the optical elements.

Magnetic connector

A magnetic connector has a receptacle and a plug. The receptacle has an electromagnet comprising an inner core, an outer core, a coil disposed around the inner core and an air gap defined by the edges of the inner and outer cores. The plug has a plug core and an anchor defined by the plug core edge. The anchor is configured to insert into the air gap as a receptacle socket electrically connects with plug pins. The coil is energized and de-energized so as to assist in the insertion or removal of the anchor from within the air gap and the corresponding connection and disconnection of the socket and pins.

Systems and methods for authorizing use of validly sold merchandise

The invention is generally directed to a method of managing the activation and use of a specific merchandise, facilitated between at least a retailer that sells the specific merchandise, a customer that purchases the specific merchandise, and a central processor that authorizes activation and use of the specific merchandise. The method includes the steps of receiving an indicia that uniquely identifies the specific merchandise, and an activation code associated with the merchandise that will allow the merchandise to properly function, storing the indicia of the specific merchandise and the activation code, receiving a confirmation of a valid purchase transaction of the specific merchandise, the confirmation of valid sale comprising the indicia of the specific merchandise, determining the activation code associated with the specific merchandise, and providing the activation code associated with the specific merchandise to the customer.