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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 210. Отображено 180.
09-06-2020 дата публикации

STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES

Номер: CA0002901684C

The present invention provides stability-modulated antibody-drug conjugates, stability-modulating linker components used to make these stability-modulated antibody-drug conjugates, and methods of making stability modulating linkers and stability-modulated antibody-drug conjugates.

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18-12-2018 дата публикации

ANTIBODIES SPECIFIC FOR TROP-2 AND THEIR USES

Номер: CA0002854720C

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.

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27-05-2014 дата публикации

METHODS FOR TREATING BONE CANCER PAIN BY ADMINISTERING A NERVE GROWTH FACTOR ANTAGONIST

Номер: CA0002562024C

The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.

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11-09-2018 дата публикации

ENGINEERED POLYPEPTIDE CONJUGATES

Номер: CA0002919583C

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug- conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.

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09-11-2021 дата публикации

ANTIBODY-DRUG CONJUGATES WITH HIGH DRUG LOADING

Номер: CA2946488C

The present invention provides transglutaminase-mediated antibody-drug conjugates with high antibody-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.

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13-09-2016 дата публикации

ANTI-NGF ANTIBODIES AND METHODS USING SAME

Номер: CA0002511598C
Принадлежит: RINAT NEUROSCIENCE CORP.

... ²²²The invention concerns anti-NGF antibodies (such as anti-NGF antagonist ²antibodies), and polynucleotides encoding the same. The invention further ²concerns use of such antibodies and/or polynucleotides in the treatment and/or ²prevention of pain, including post-surgical pain, rheumatoid arthritis pain, ²and osteoarthritis pain.² ...

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04-12-2012 дата публикации

ANTAGONIST ANTIBODIES DIRECTED AGAINST CALCITONIN GENE-RELATED PEPTIDE AND METHODS USING SAME

Номер: CA0002626120C

The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.

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26-05-2020 дата публикации

ANTI-NGF ANTIBODIES AND METHODS USING SAME

Номер: CA0002936742C

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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08-10-2013 дата публикации

METHODS OF TREATING OPHTHALMIC DISEASES

Номер: CA0002680222C

Methods of using inhibitors (including monoclonal antibodies) directed against amyloid-beta peptide for the treatment of ophthalmic diseases such as age-related macular degeneration are described.

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19-01-2012 дата публикации

PCSK9 ANTAGONISTS

Номер: US20120014951A1
Принадлежит: PFIZER INC., RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.

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18-11-2010 дата публикации

ANTIBODIES SPECIFIC FOR DKK-1 AND THEIR USES

Номер: US20100291076A1
Принадлежит: PFIZER INC., RINAT NEUROSCIENCE CORP.

The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided are antibodies and fragments thereof which compete with the binding of an anti-mouse Dkk-1 monoclonal antibody for binding to Dkk-1+ cells. Also provided are nucleic acids encoding anti-Dkk-1 antibodies or fragments thereof, as well as expression vectors and host cells incorporating these nucleic acids for the recombinant expression of anti-Dkk-1 antibodies and fragments thereof. Also provided are methods of preparing the antibodies and fragments thereof of the invention. Also provided are bone anabolic agents. Pharmaceutical compositions comprising the antibodies or fragments thereof of the invention are also provided. Further provided are methods of treating diseases, conditions and disorders ...

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27-06-2013 дата публикации

STAPHYLOCOCCUS AUREUS SPECIFIC ANTIBODIES AND USES THEREOF

Номер: US20130164308A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess.

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19-03-2013 дата публикации

Antibodies directed against amyloid-beta peptide and methods using same

Номер: US0008398978B2

Methods of using antibodies directed to the C-terminal side of -amyloid peptide for diagnosing and treatment of Alzheimer's disease and A peptide associated diseases are described.

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26-11-2020 дата публикации

ANTI-PD-1 ANTIBODIES AND METHODS OF USE THEREOF

Номер: US20200368349A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases. 138-. (canceled)39. A method for treating cancer in a subject in need thereof , the method comprising administering to the subject (1) an effective amount of an isolated antagonist antibody that specifically binds to PD-1 and comprises:a heavy chain variable region (VH) comprising a VH complementarity determining region one (CDR1), VH CDR2, and VH CDR3 of the VH having an amino acid sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 4; SEQ ID NO: 5; and SEQ ID NO: 6; anda light chain variable region (VL) comprising a VL CDR1, VL CDR2, and VL CDR3 of the VL having an amino acid sequence selected from the group consisting of SEQ ID NO: 2; SEQ ID NO:7; SEQ ID NO: 8; and SEQ ID NO: 9,and (2) an effective amount of a vaccine capable of eliciting an immune response against cells of the cancer.40. A method for enhancing the immunogenicity or therapeutic effect of a vaccine administered to a subject for the treatment of cancer , the method comprising administering to the subject receiving the vaccine an effective amount of an isolated antagonist antibody that specifically binds to PD-1 and comprises:a heavy chain variable region (VH) comprising a VH complementarity determining region one (CDR1), VH CDR2, and VH CDR3 of the VH having an amino acid sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 4; SEQ ID NO: 5; and SEQ ID NO: 6; anda light chain variable region (VL) comprising a VL CDR1, VL CDR2, and VL CDR3 of the VL having an amino acid sequence selected from the group consisting of SEQ ID NO: 2; SEQ ID NO:7; SEQ ID NO: 8; and SEQ ID NO: 9.41. The method of claim 39 , wherein the cancer is selected from the group consisting of breast cancer claim 39 , gastric ...

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03-04-2018 дата публикации

USE OF ANTI-NGF ANTIBODY FOR IMPROVING STIFFNESS IN OSTEOARTHRITIS

Номер: CA0002604443C
Принадлежит: RINAT NEUROSCIENCE CORP.

... ²The invention concerns anti-NGF antibodies (such as anti-NGF antagonist ²antibodies ²e.g. E3 anti-NGF antibody comprising the heavy chain CDRs of SEQ ID NOs: 3-5 ²and the light chain CDRs of SEQ ID NOs: 6-8), and polynucleotides encoding the ²²same. The invention further concerns use of such antibodies and/or ²polynucleotides ²in the treatment and/or prevention of pain, including post-surgical pain, ²rheumatoid ²arthritis pain, and osteoarthritis pain.²² ...

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29-11-2016 дата публикации

ANTAGONIST IL-7 RECEPTOR ANTIBODIES TO TREAT TYPE 2 DIABETES AND IMMUNOLOGICAL DISORDERS

Номер: CA0002789132C

The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.

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20-10-2020 дата публикации

ENGINEERED POLYPEPTIDE CONJUGATES

Номер: CA0003012994C

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.

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23-04-2013 дата публикации

ANTIBODIES DIRECTED AGAINST AMYLOID-BETA PEPTIDE AND METHODS USING SAME

Номер: CA0002575663C
Принадлежит: RINAT NEUROSCIENCE CORP.

... ²²²Monoclonal antibody 9TL and antibodies derived from 9TL directed against ²amyloid-beta peptide and methods of using same for diagnosing and treatment of ²Alzheimer's disease and A.beta. peptide associated diseases are described. ²Methods of using antibodies directed against amyloid-beta peptide having ²impaired effector function for treatment of Alzheimer's disease and A.beta. ²peptide associated diseases are also described.² ...

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15-12-2015 дата публикации

Anti-NGF antibodies and methods using same

Номер: US0009212222B2

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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18-12-2018 дата публикации

Anti-PD-1 antibodies and methods of use thereof

Номер: US0010155037B2

The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

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20-10-2022 дата публикации

HETERODIMERIC PROTEINS AND METHODS FOR PRODUCING AND PURIFYING THEM

Номер: US20220332850A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglubulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

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10-06-2014 дата публикации

ANTIBODIES DIRECTED AGAINST AMYLOID-BETA PEPTIDE AND METHODS USING SAME

Номер: CA0002605759C
Принадлежит: RINAT NEUROSCIENCE CORP.

Antibodies directed to the C-terminal side of .beta.-amyloid peptide and methods of using these antibodies for diagnosing and treatment of Alzheimer's disease and A.beta. peptide associated diseases are described.

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14-02-2017 дата публикации

ANTI-NGF ANTIBODIES AND METHODS USING SAME

Номер: CA0002921578C

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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24-02-2011 дата публикации

ANTIBODIES DIRECTED AGAINST AMYLOID-BETA PEPTIDE AND METHODS USING SAME

Номер: US20110044985A1
Принадлежит: RINAT NEUROSCIENCE CORP.

Methods of using antibodies directed to the C-terminal side of β-amyloid peptide for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described.

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12-09-2013 дата публикации

ANTIBODIES DIRECTED AGAINST AMYLOID-BETA PEPTIDE AND METHODS USING SAME

Номер: US20130236451A1
Принадлежит: RINAT NEUROSCIENCE CORP.

Antibodies directed to the C-terminal side of β-amyloid peptide and methods of using these antibodies for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. 1. A monoclonal antibody that specifically binds to a β-amyloid peptide or an aggregated form of a β-amyloid peptide , wherein the said antibody binds to an epitope on Aβthat includes amino acids 25-34 and 40 , wherein said antibody binds to Aβwith higher affinity than its binding to Aβand Aβ , wherein said antibody binds to Aβwith a Kof less than 1 μm.2. The antibody of claim 1 , wherein the isotype of the antibody is selected from the group consisting of IgG1 claim 1 , IgG2 claim 1 , IgG3 claim 1 , and IgG4.3. The antibody of claim 1 , wherein N-glycosylation in the Fc region of the antibody is removed.4. The antibody of claim 1 , wherein the heavy chain constant region of the antibody is a human IgG2a constant region comprising amino acid mutations A330P331 to S330S331 claim 1 , wherein the amino acid position is based on Kabat numbering with reference to human wildtype IgG2a sequence.5. A pharmaceutical composition comprising the antibody of and a pharmaceutically acceptable carrier.6. A method for treating a disease associated with aberrant deposition of β-amyloid in a subject claim 1 , comprising administering to the subject an effective amount of an antibody that specifically binds to a β-amyloid peptide or an aggregated form of a β-amyloid peptide claim 1 , wherein the said antibody binds to an epitope on Aβthat includes amino acids 25-34 and 40 claim 1 , wherein said antibody binds to Aβwith higher affinity than its binding to Aβand Aβ claim 1 , wherein said antibody binds to Aβwith a Kof less than 1 μM.7. The method of claim 6 , wherein the antibody comprises a Fab fragment which binds Aβwith an affinity of about 10 nM or less.8. The method of claim 6 , wherein the antibody prevents claim 6 , treats claim 6 , inhibits or delays development of a disease ...

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03-01-2012 дата публикации

Anti-NGF antibodies and methods using same

Номер: US0008088384B2

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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18-03-2010 дата публикации

PCSK9 ANTAGONISTS

Номер: US20100068199A1
Принадлежит: RINAT NEUROSCIENCE CORP., PFIZER INC.

The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.

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08-07-2021 дата публикации

STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES

Номер: US20210205463A1
Принадлежит: PFIZER INC., RINAT NEUROSCIENCE CORP.

The present invention provides stability-modulated antibody-drug conjugates, stability-modulating linker components used to make these stability-modulated antibody-drug conjugates, therapeutic methods using stability-modulated antibody-drug conjugates, and methods of making stability modulating linkers and stability-modulated antibody-drug conjugates.

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19-01-2012 дата публикации

PCSK9 ANTAGONISTS

Номер: US20120015435A1
Принадлежит: PFIZER INC., RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.

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16-09-2008 дата публикации

Methods for treating bone cancer pain by administering a nerve growth factor antagonist

Номер: US0007425329B2

The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.

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28-06-2011 дата публикации

Agonist anti-trkC antibodies and methods using same

Номер: US0007968690B2
Автор: Jaume Pons, PONS JAUME

The invention concerns agonist anti-trkC antibodies, polypeptides, and polynucleotides encoding the same. The invention further concerns use of such antibodies, polypeptides and/or polynucleotides in the treatment and/or prevention of neuropathies, such as sensory neuropathies, including taxol-induced sensory neuropathy, cisplatin-induced sensory neuropathy, and pyridoxine-induced sensory neuropathy.

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15-11-2018 дата публикации

ANTAGONIST ANTI-IL-7 RECEPTOR ANTIBODIES AND METHODS

Номер: US20180327503A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus. 1. An isolated interleukin-7 receptor (IL-7R) antibody which specifically binds to interleukin-7 receptor alpha (IL-7Rα) and comprises an antigen binding region that cross-competes with a monoclonal antibody selected from the group consisting of P3A9 , P4B3 , P2D2 , P2E11 , HAL403a , HAL403b , C1GM and C2M3 , for binding to IL-7Rα.2. The antibody of claim 1 , wherein the antibody binds to an epitope comprising residues I82 claim 1 , K84 claim 1 , K100 claim 1 , T105 claim 1 , and Y192 of human IL-7Rα.3. An isolated antibody which specifically binds to interleukin-7 receptor alpha (IL-7Rα) claim 1 , wherein the antibody comprises a heavy chain variable region (VH) complementary determining region one (CDR1) having the amino acid sequence XXVMH claim 1 , wherein Xis D or N; Xis S or Y (SEQ ID NO: 50) claim 1 , a VH CDR2 having the amino acid sequence XXXXXGXXTYYADSVKG claim 1 , wherein Xis L or A; Xis V or I; Xis G or S claim 1 , Xis W or G claim 1 , Xis D or S claim 1 , Xis F claim 1 , G or S claim 1 , Xis F claim 1 , A or S (SEQ ID NO: 51) claim 1 , and a VH CDR3 having the amino acid sequence XXXXXXXX claim 1 , wherein Xis Q or D; Xis G or I; Xis D or S claim 1 , Xis Y or G claim 1 , Xis M claim 1 , V or G; Xis G or F; Xis N claim 1 , D or M; Xis N claim 1 , Y or D (SEQ ID NO: 52) claim 1 , a light chain variable region (VL) CDR1 having the amino acid sequence TXSSGXIXSSYVQ wherein Xis R or G; Xis S or R Xis D or A (SEQ ID NO: 53) claim 1 , a VL CDR2 having ...

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02-02-2016 дата публикации

Anti-glucagon receptor antibodies and pharmaceutical compositions thereof

Номер: US0009248189B2

The present invention provides antagonizing antibodies that bind to glucagon receptor and methods of using same. The anti-glucagon receptor antibodies can be used therapeutically to lower glucose levels in blood, and can be in the prevention and/or treatment of glucose-related disorders, including diabetes, hyperglycemia, hyperinsulinemia, impaired fasting glucose, impaired glucose tolerance, dyslipidemia, or metabolic syndrome.

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21-03-2013 дата публикации

ANTIBODIES SPECIFIC FOR DKK-1 AND THEIR USES

Номер: US20130071921A1
Принадлежит: RINAT NEUROSCIENCE CORP., PFIZER INC.

The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided are antibodies and fragments thereof which compete with the binding of an anti-mouse Dkk-1 monoclonal antibody for binding to Dkk-1+ cells. Also provided are nucleic acids encoding anti-Dkk-1 antibodies or fragments thereof, as well as expression vectors and host cells incorporating these nucleic acids for the recombinant expression of anti-Dkk-1 antibodies and fragments thereof. Also provided are methods of preparing the antibodies and fragments thereof of the invention. Also provided are bone anabolic agents. Pharmaceutical compositions comprising the antibodies or fragments thereof of the invention are also provided. Further provided are methods of treating diseases, conditions and disorders ...

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18-06-2019 дата публикации

Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same

Номер: US0010323086B2

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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18-01-2007 дата публикации

Methods for treating taxol-induced gut disorder

Номер: US20070014786A1
Автор: David Shelton
Принадлежит: RINAT NEUROSCIENCE CORP.

This invention relates to the field of taxol-induced gut disorder. More specifically, the invention relates to methods of treating taxol-induced gut disorder comprising administration of agonist anti-trkC antibody for the treatment, prevention, and/or amelioration of a symptom of taxol-induced gut disorder.

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09-04-2020 дата публикации

ANTIBODY-DRUG CONJUGATES WITH HIGH DRUG LOADING

Номер: PT0003134127T
Автор:

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03-06-2021 дата публикации

ENGINEERED POLYPEPTIDE CONJUGATES USING TRANSGLUTAMINASE

Номер: US20210162058A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof. 128-. (canceled)29. A method of treating a cancer in a subject in need thereof , comprising administering to the subject an effective amount of an engineered polypeptide conjugate comprising the formula: polypeptide-T-A , wherein T is an acyl donor glutamine-containing tag engineered at a specific site , wherein A is an amine donor agent , wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag at a carboxyl terminus , an amino terminus , or at an another site in the polypeptide , and wherein the acyl donor glutamine-containing tag comprises an amino acid sequence GGLLQGPP (SEQ ID NO:13).30. A method of treating a cancer in a subject in need thereof , comprising administering to the subject an effective amount of an engineered Fc-containing polypeptide conjugate comprising the formula: (Fc-containing polypeptide-T-A) , wherein T is an acyl donor glutamine-containing tag engineered at a specific site , wherein A is an amine donor agent , wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag at a carboxyl terminus , an amino terminus , or at an another site in the Fc-containing polypeptide , wherein the acyl donor glutamine-containing tag comprises an amino acid sequence XXQX (SEQ ID NO:35) , LLQ , or GLLQ (SEQ ID NO: 24) , wherein X is any amino acid , and wherein the engineered Fc-containing polypeptide conjugate comprises an amino acid substitution from glutamine to asparagine at position 295 (Q295N; EU numbering scheme).31. The method of claim 30 , wherein the acyl donor glutamine-containing tag comprises an amino acid sequence selected from the group ...

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24-10-2019 дата публикации

ENGINEERED POLYPEPTIDE CONJUGATES USING TRANSGLUTAMINASE

Номер: US20190321482A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof. 122-. (canceled)23. A method for preparing an engineered polypeptide conjugate comprising the formula: polypeptide-T-A , wherein T is an acyl donor glutamine-containing tag engineered at a specific site , wherein A is an amine donor agent , wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag at a carboxyl terminus , an amino terminus , or at an another site in the polypeptide , and wherein the acyl donor glutamine-containing tag comprises an amino acid sequence LLQGPX , wherein X is A or P (SEQ ID NO:14) , or GGLLQGPP (SEQ ID NO:13) , comprising the steps of:a) providing an engineered polypeptide-T molecule comprising the Fc-containing polypeptide and the acyl donor glutamine-containing tag;b) contacting the amine donor agent with the engineered polypeptide-T molecule in the presence of a transglutaminase; andc) allowing the engineered polypeptide-T to covalently link to the amine donor agent to form the engineered Fc-containing polypeptide conjugate.24. The method of claim 23 , wherein the engineered polypeptide conjugate has conjugation efficiency of at least about 51%.25. The method of claim 23 , wherein the transglutaminase is a microbial claim 23 , purified claim 23 , or engineered transglutaminase.26. The method of claim 23 , further comprising a purification step claim 23 , wherein the engineered polypeptide conjugate is purified by a chromatography step.27. The method claim 23 , wherein the engineered polypeptide-T molecule is expressed in CHO cells.28. The method of claim 23 , wherein the polypeptide is Fc-containing or Fab-containing polypeptide. This application claims the benefits of U.S. ...

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25-12-2012 дата публикации

Antibodies specific for DKK-1 and their uses

Номер: US0008338576B2

The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided are antibodies and fragments thereof which compete with the binding of an anti-mouse Dkk-1 monoclonal antibody for binding to Dkk-1+ cells. Also provided are nucleic acids encoding anti-Dkk-1 antibodies or fragments thereof, as well as expression vectors and host cells incorporating these nucleic acids for the recombinant expression of anti-Dkk-1 antibodies and fragments thereof. Also provided are methods of preparing the antibodies and fragments thereof of the invention. Also provided are bone anabolic agents. Pharmaceutical compositions comprising the antibodies or fragments thereof of the invention are also provided. Further provided are methods of treating diseases, conditions and disorders ...

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14-08-2007 дата публикации

Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody

Номер: US0007255860B2

The invention features methods and compositions for preventing or treating post-surgical pain by administering an anti-NGF antagonist antibody.

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30-10-2012 дата публикации

Anti-IL-7 receptor antibodies

Номер: US0008298535B2

The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.

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19-04-2011 дата публикации

Antibodies directed against amyloid-beta peptide

Номер: US0007927594B2

Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and A peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and A peptide associated diseases are also described.

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27-12-2016 дата публикации

Heterodimeric proteins and methods for producing and purifying them

Номер: US9527926B2

The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

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09-03-2021 дата публикации

Engineered polypeptide conjugates and methods for making thereof using transglutaminase

Номер: US0010941216B2

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.

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22-04-2021 дата публикации

ENGINEERED POLYPEPTIDE CONJUGATES AND METHODS FOR MAKING THEREOF USING TRANSGLUTAMINASE

Номер: US20210115159A1
Принадлежит: PFIZER INC., RINAT NEUROSCIENCE CORP.

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.

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16-10-2018 дата публикации

Antibodies specific for TROP-2 and their uses

Номер: US0010100114B2

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.

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24-05-2022 дата публикации

Anti-PD-1 antibodies and methods of use thereof

Номер: US0011338035B2
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

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31-01-2013 дата публикации

ANTAGONIST ANTI-IL-7 RECEPTOR ANTIBODIES AND METHODS

Номер: US20130028916A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.

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23-04-2013 дата публикации

Method for reducing a level of LDL-cholesterol by an antibody that specifically binds to PCSK9

Номер: US0008426363B2

The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.

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11-10-2011 дата публикации

Methods for treating pain by administering a nerve growth factor antagonist and an NSAID and compositions containing the same

Номер: US0008034346B2

The present invention features methods for treating or preventing pain comprising administering an amount of a nerve growth factor antagonist (such as an anti-NGF antibody) and an amount of an NSAID such that together they provide effective pain relief. The invention also features compositions comprising a nerve growth factor antagonist and an NSAID and kits containing the same.

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18-09-2012 дата публикации

Polynucleotides encoding antibodies directed against amyloid-beta peptide

Номер: US0008268593B2

Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and A peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and A peptide associated diseases are also described.

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02-06-2016 дата публикации

ANTI-NGF ANTIBODIES AND METHODS USING SAME

Номер: US20160152698A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain. 133-. (canceled)34. A method for treating post-herpetic neuralgia in an individual comprising administering an effective amount of a monoclonal anti-NGF antagonist antibody to an individual suffering from post-herpetic neuralgia , thereby treating post-herpetic neuralgia in said individual.35. The method of claim 34 , wherein the antibody is administered at a dosing frequency in a range from once every week to once every twelve weeks.36. The method of claim 34 , wherein the antibody is administered once every month claim 34 , once every two months claim 34 , once every three months claim 34 , once every four months claim 34 , once every five months claim 34 , or once every six months.37. The method of claim 34 , wherein the antibody is administered once every three months.38. The method of claim 34 , wherein the antibody is administered at a dose in a range from about 3 μg/kg to about 1 mg/kg.39. The method of claim 34 , wherein the antibody is administered at a dose of about 100 μg/kg.40. The method of claim 34 , wherein the antibody is administered at a dose of about 300 μg/kg.41. The method of claim 34 , wherein the antibody is administered intravenously or subcutaneously.42. The method of claim 34 , wherein the antibody is a humanized antibody or a human antibody.43. The method of claim 34 , wherein the antibody (a) blocks the interaction of human NGF with p75 and trkA claim 34 , (b) binds human NGF with a Kof less than about 2 nM claim 34 , and (c) blocks human NGF-dependent neuron survival.44. The method of claim 34 , wherein the antibody comprises a heavy chain variable region (VH) comprising three CDRs of the sequence shown in SEQ ID NO: ...

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24-05-2018 дата публикации

STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES

Номер: US20180140714A1
Принадлежит: PFIZER INC., RINAT NEUROSCIENCE CORP.

The present invention provides stability-modulated antibody-drug conjugates, stability-modulating linker components used to make these stability-modulated antibody-drug conjugates, therapeutic methods using stability-modulated antibody-drug conjugates, and methods of making stability modulating linkers and stability-modulated antibody-drug conjugates.

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17-02-2011 дата публикации

Methods of Treating Alzheimer's Disease Using Antibodies Directed Against Amyloid Beta Peptide and Compositions Thereof

Номер: US20110038861A1
Принадлежит: RINAT NEUROSCIENCE CORP.

Monoclonal antibodies directed against amyloid beta peptide and methods of using same for treatment and prevention of Alzheimer's disease and Down's syndrome are described.

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28-06-2013 дата публикации

ANTIBODIES DIRECTED AGAINST AMYLOID-BETA PEPTIDE AND METHODS USING SAME

Номер: SG0000190665A1

Monoclonal antibody 9TL and antibodies derived from 9TL directed ag st amyloid-beta peptide and methods of using same for diagnosing and treatm of Alzheimer's disease and amyloid-beta peptide associated diseases are de ribed. Methods of using antibodies directed against amyloid-beta peptide havin mpaired effector function for treatment of Alzheimer's disease and amyloid-b a peptide associated diseases are also described.(no suitable figure) ANTIBODIES DIRECTED AGAINST AMYLOID-BETA PEPTIDE AND METHODS USING SAMEAbstractMonoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and amyloid-beta peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and amyloid-beta peptide associated diseases are also described.(no suitable figure) ...

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22-09-2011 дата публикации

Antibodies with pH Dependent Antigen Binding

Номер: US20110229489A1
Принадлежит: RINAT NEUROSCIENCE CORP., PFIZER INC.

The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the KD or koff ratio at pH 5.5/pH 7.4 or at pH 6.0/pH 7.4 is more than, or ranges between, 2, 3, 4, 8, 10, 16, 20, 30, 40, or 100 or more. Such pH dependent antibodies preferentially dissociate from the antigen in the endosome. This can increase antibody half life, as compared to antibodies with equivalent KDs at pH 7.4 but with no pH dependent binding, when the antigen is one that undergoes antigen-mediated clearance (e.g., PCSK9). Antibodies with pH dependent binding can decrease total antigen half life when the antigen undergoes reduced clearance when bound to antibody (e.g., IL6). Antibodies with pH dependent binding can also prolong the decrease in antigen which is not antibody-bound. This can be important when antagonizing a target antigen typically present ...

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18-07-2017 дата публикации

Anti-NGF antibodies and methods using same

Номер: US0009708398B2

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

Подробнее
26-07-2016 дата публикации

Antibodies specific for trop-2 and their uses

Номер: US0009399074B2

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.

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02-03-2017 дата публикации

HETERODIMERIC PROTEINS AND METHODS FOR PRODUCING AND PURIFYING THEM

Номер: US20170058054A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglubulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. 172-. (canceled)73. A heterodimeric protein comprising:{'figref': [{'@idref': 'DRAWINGS', 'FIG. 6A'}, {'@idref': 'DRAWINGS', 'FIG. 10'}], 'a hinge region comprising a first immunoglobulin-like hinge polypeptide and a second immunoglobulin-like hinge polypeptide which interact together to form a dimeric hinge interface, wherein electrostatic interactions between one or more charged amino acids within the hinge interface favor interaction between the first and second hinge polypeptides over interaction between two first hinge polypeptides or two second hinge polypeptides, thereby promoting heterodimer formation over homodimer formation, wherein the hinge region is a human IgG1 hinge region, wherein the first hinge polypeptide comprises at least one amino acid modification relative to a wild-type IgG hinge region; wherein the wild-type amino acid in the first hinge polypeptide is replaced with an amino acid having an opposite charge to the corresponding amino acid in the second hinge polypeptide, wherein the amino acid modification in the hinge region is at a position selected from the group consisting of Asp221 and Pro228 as shown at , and further comprising an immunoglobulin-like CH3 region comprising a first CH3 polypeptide fused to the first hinge polypeptide and a second CH3 polypeptide fused to the second hinge polypeptide, wherein the first CH3 polypeptide and the second CH3 polypeptide comprise at least one amino acid modification relative to a wild-type IgG1 CH3 region sequence at a position selected from the group consisting of Tyr349, Leu368, Phe405, and ...

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21-03-2019 дата публикации

ANTI-PD-1 ANTIBODIES AND METHODS OF USE THEREOF

Номер: US20190083612A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases. 128-. (canceled)29. A method for treating cancer in a subject in need thereof , the method comprising administering to the individual an effective amount of an antagonist antibody that specifically binds to programmed cell death 1 (PD-1) and comprises:a heavy chain variable region (VH) comprising a VH complementarity determining region one (CDR1), VH CDR2, and VH CDR3 of the VH having an amino acid sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, and SEQ ID NO: 6; anda light chain variable region (VL) comprising a VL CDR1, VL CDR2, and VL CDR3 of the VL having an amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NO: 8, and SEQ ID NO: 9,such that one or more symptoms associated with the cancer is ameliorated in the individual.30. The method of claim 29 , wherein the cancer is selected from the group consisting of gastric cancer claim 29 , sarcoma claim 29 , lymphoma claim 29 , Hodgkin's lymphoma claim 29 , leukemia claim 29 , head and neck cancer claim 29 , squamous cell head and neck cancer claim 29 , thymic cancer claim 29 , epithelial cancer claim 29 , salivary cancer claim 29 , liver cancer claim 29 , stomach cancer claim 29 , thyroid cancer claim 29 , lung cancer claim 29 , ovarian cancer claim 29 , breast cancer claim 29 , prostate cancer claim 29 , esophageal cancer claim 29 , pancreatic cancer claim 29 , glioma claim 29 , leukemia claim 29 , multiple myeloma claim 29 , renal cell carcinoma claim 29 , bladder cancer claim 29 , cervical cancer claim 29 , choriocarcinoma claim 29 , colon cancer claim 29 , oral cancer claim 29 , skin cancer claim 29 , and melanoma.31. The method of claim 29 , wherein the individual ...

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07-08-2007 дата публикации

Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist

Номер: US0007252822B2

The invention features methods and compositions for preventing or treating pain resulting from surgery or an incision by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.

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22-11-2016 дата публикации

Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same

Номер: US0009498530B2

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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16-02-2017 дата публикации

ANTIBODY-DRUG CONJUGATES WITH HIGH DRUG LOADING

Номер: US20170043033A1
Принадлежит: RINAT NEUROSCIENCE CORP., PFIZER INC.

The present invention provides transglutaminase-mediated antibody-drug conjugates with high anti-body-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.

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24-05-2016 дата публикации

Method of treating type 1 diabetes with antagonist IL-7 receptor antibodies

Номер: US0009346885B2

The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.

Подробнее
17-08-2021 дата публикации

Antibodies specific for Trop-2 and their uses

Номер: US0011091544B2

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.

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05-02-2019 дата публикации

Engineered polypeptide conjugates using transglutaminase

Номер: US0010195289B2

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.

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28-10-2014 дата публикации

Antibodies specific for Trop-2 and their uses

Номер: US0008871908B2

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.

Подробнее
26-05-2020 дата публикации

Anti-PD-1 antibodies and methods of use thereof

Номер: US0010660953B2

The present invention provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

Подробнее
15-10-2013 дата публикации

Methods for treating bone cancer by administering a nerve growth factor antagonist antibody

Номер: US0008557245B2

The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) antibody that is capable of binding hNGF.

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12-04-2018 дата публикации

TREATMENT WITH ANTI-EFNA4 ANTIBODY-DRUG CONJUGATES

Номер: US20180099054A1
Принадлежит: PFIZER INC., RINAT NEUROSCIENCE CORP.

The present invention provides for dosing regimens for the treatment of patients with cancer and/or an EFNA4-associated disorder with an anti-EFNA4 antibody-drug conjugate (ADC). The present invention further provides for methods for the treatment of patients with cancer and/or an EFNA4-associated disorder in which an anti-EFNA4 ADC is administered intravenously weekly (QW) or every 3 weeks (Q3W).

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19-07-2022 дата публикации

Heterodimeric proteins and methods for producing and purifying them

Номер: US0011390689B2
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

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16-01-2014 дата публикации

METHODS FOR TREATING OSTEOARTHRITIS PAIN BY ADMINISTERING A NERVE GROWTH FACTOR ANTAGONIST AND COMPOSITIONS CONTAINING THE SAME

Номер: US20140017235A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain. 185-. (canceled)86. A method for treating osteoarthritis pain comprising administering an effective amount of a monoclonal anti-NGF antagonist antibody to an individual having osteoarthritis , thereby treating osteoarthritis pain in said individual.87. The method of claim 86 , wherein the antibody is administered at a dosing frequency in a range from once every week to once every twelve weeks.88. The method of claim 86 , wherein the antibody is administered once every month claim 86 , once every two months claim 86 , once every three months claim 86 , once every four months claim 86 , once every five months claim 86 , or once every six months.89. The method of claim 86 , wherein the antibody is administered once every three months.90. The method of claim 86 , wherein the antibody is administered at a dose in a range from about 3 μg/kg to about 1 mg/kg.91. The method of claim 86 , wherein the antibody is administered at a dose of about 100 μg/kg.92. The method of claim 86 , wherein the antibody is administered at a dose of about 300 μg/kg.93. The method of claim 86 , wherein the antibody is administered intravenously or subcutaneously.94. The method of claim 86 , wherein the antibody is a humanized antibody or a human antibody.95. The method of claim 86 , wherein the antibody (a) blocks the interaction of human NGF with p75 and trkA claim 86 , (b) binds human NGF with a Kof less than about 2 nM claim 86 , and (c) blocks human NGF-dependent neuron survival claim 86 , thereby treating osteoarthritis pain in the individual.96. The method of claim 86 , wherein the antibody comprises a heavy chain variable region (VH) comprising three CDRs of the ...

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04-04-2019 дата публикации

HETERODIMERIC PROTEINS AND METHODS FOR PRODUCING AND PURIFYING THEM

Номер: US20190100603A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. 152-. (canceled)53. A cell line expressing a heterodimeric protein , wherein the heterodimeric protein comprises:{'figref': [{'@idref': 'DRAWINGS', 'FIG. 6A'}, {'@idref': 'DRAWINGS', 'FIG. 10'}], 'a hinge region comprising a first immunoglobulin-like hinge polypeptide and a second immunoglobulin-like hinge polypeptide which interact together to form a dimeric hinge interface, wherein electrostatic interactions between one or more charged amino acids within the hinge interface favor interaction between the first and second hinge polypeptides over interaction between two first hinge polypeptides or two second hinge polypeptides, thereby promoting heterodimer formation over homodimer formation, wherein the hinge region is a human IgG1 or IgG2 hinge region, wherein the first hinge polypeptide comprises at least one amino acid modification relative to a wild-type IgG hinge region; wherein the wild-type amino acid in the first hinge polypeptide is replaced with an amino acid having an opposite charge to the corresponding amino acid in the second hinge polypeptide, wherein the amino acid modification in the hinge region is at a position selected from the group consisting of 1) Asp221 or 2) Cys223 and/or Glu225 as shown at , and further comprising an immunoglobulin-like CH3 region comprising a first CH3 polypeptide fused to the first hinge polypeptide and a second CH3 polypeptide fused to the second hinge polypeptide, wherein the first CH3 polypeptide and the second CH3 polypeptide comprise at least one amino acid modification relative to a wild-type IgG1 CH3 region ...

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12-05-2015 дата публикации

Anti-PCSK9 antibodies with pH dependent antigen binding

Номер: US0009029515B2

The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the KD or koff ratio at pH 5.5/pH 7.4 or at pH 6.0/pH 7.4 is more than, or ranges between, 2, 3, 4, 8, 10, 16, 20, 30, 40, or 100 or more. Such pH dependent antibodies preferentially dissociate from the antigen in the endosome. This can increase antibody half life, as compared to antibodies with equivalent KDs at pH 7.4 but with no pH dependent binding, when the antigen is one that undergoes antigen-mediated clearance (e.g., PCSK9). Antibodies with pH dependent binding can decrease total antigen half life when the antigen undergoes reduced clearance when bound to antibody (e.g., IL6). Antibodies with pH dependent binding can also prolong the decrease in antigen which is not antibody-bound. This can be important when antagonizing a target antigen typically present ...

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07-04-2016 дата публикации

PC33718E

Номер: US20160096898A1
Принадлежит: PFIZER INC., RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.

Подробнее
28-11-2018 дата публикации

ANTI-NGF ANTIBODIES AND METHODS USING SAME

Номер: PT0002263692T

Подробнее
13-01-2011 дата публикации

POLYNUCLEOTIDES ENCODING ANTIBODIES DIRECTED AGAINST AMYLOID-BETA PEPTIDE

Номер: US20110008834A1
Принадлежит: RINAT NEUROSCIENCE CORP.

Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.

Подробнее
05-10-2010 дата публикации

Antibodies directed against amyloid-beta peptide and methods using same

Номер: US0007807165B2

Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and A peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and A peptide associated diseases are also described.

Подробнее
25-10-2012 дата публикации

Antibodies directed against amyloid-beta peptide and methods using same

Номер: US20120269805A1
Принадлежит: Rinat Neuroscience Corp

Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.

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09-05-2013 дата публикации

HETERODIMERIC PROTEINS AND METHODS FOR PRODUCING AND PURIFYING THEM

Номер: US20130115208A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. 1. A heterodimeric protein comprising:a hinge region comprising a first immunoglobulin-like hinge polypeptide and a second immunoglobulin-like hinge polypeptide which interact together to form a dimeric hinge interface, wherein electrostatic interactions between one or more charged amino acids within the hinge interface favor interaction between the first and second hinge polypeptides over interaction between two first hinge polypeptides or two second hinge polypeptides, thereby promoting heterodimer formation over homodimer formation.2. The heterodimeric protein of claim 1 , wherein the hinge region is an IgG hinge region.3. (canceled)4. The heterodimeric protein of claim 2 , wherein the first hinge polypeptide comprises at least one amino acid modification relative to a wild-type IgG hinge region; and the second hinge polypeptide comprises at least one amino acid modification relative to a wild-type IgG hinge region at the same position as the amino acid modification in the first hinge polypeptide claim 2 , wherein the wild-type amino acid in the second hinge polypeptide is replaced with an amino acid having an opposite charge to the corresponding amino acid modification in the first hinge polypeptide.5. The heterodimeric protein of claim 4 , wherein the amino acid modifications are selected from the group consisting of Lys claim 4 , Arg claim 4 , Asp claim 4 , and Glu.6. The heterodimeric protein of claim 4 , wherein the IgG hinge region comprises a human IgG hinge region.7. The heterodimeric protein of claim 6 , wherein the human IgG hinge region comprises a ...

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16-05-2013 дата публикации

Antibodies specific for trop-2 and their uses

Номер: US20130122020A1
Принадлежит: Rinat Neuroscience Corp

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.

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03-01-2019 дата публикации

ANTIBODIES SPECIFIC FOR TROP-2 AND THEIR USES

Номер: US20190002559A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer. 1. An isolated polynucleotide comprising a nucleotide sequence encoding an antibody which specifically binds to Trop-2 , wherein the antibody comprises{'sub': 1', '2', '1', '2', 'i', '1', '1', '1, '(a) a heavy chain variable (VH) region comprising (i) a VH complementarity determining region one (CDR1) comprising the sequence SYWIN (SEQ ID NO: 40), GYTFTSY (SEQ ID NO: 41), or GYTFTSYWIN (SEQ ID NO: 42); (ii) a VH CDR2 comprising the sequence NIXPSDSYSNYNXKFKD wherein Xis Y or F; Xis Q or K (SEQ ID NO: 51), or XPSDSY wherein Xis Y or F (SEQ ID NO: 52); and iii) a VH CDR3 comprising the sequence GSXFDY wherein Xis S or G (SEQ ID NO: 53); and'}{'sub': 1', '2', '1', '2, '(b) a light chain variable region (VL) region comprising (i) a VL CDR1 comprising the sequence RASQTIGTSIH (SEQ ID NO: 59); (ii) a VL CDR2 comprising the sequence YASESIS (SEQ ID NO: 60); and (iii) a VL CDR3 comprising the sequence XQSXSWPFT wherein Xis Q or S; Xis N or F (SEQ ID NO:64).'}2. An isolated polynucleotide comprising a nucleotide sequence encoding an antibody which specifically binds to Trop-2 , wherein the antibody comprises:a VH region comprising a VH CDR1, VH CDR2, and VH CDR3 of the VH sequence shown in SEQ ID NO: 13; anda VL region comprising VL CDR1, VL CDR2, and VL CDR3 of the VL sequence shown in SEQ ID NO: 12.3. The isolated polynucleotide of claim 2 , wherein the VH region comprises (i) a VH CDR1 comprising the sequence SYWIN (SEQ ID NO: 40) ...

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22-05-2014 дата публикации

ANTAGONIST ANTI-IL-7 RECEPTOR ANTIBODIES AND METHODS

Номер: US20140141018A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus. 114-. (canceled)15. A method for treating and/or preventing an autoimmune disorder in an individual , the method comprising administering a therapeutically effective amount of an antagonist IL-7R antibody to an individual suffering from or at risk for an autoimmune disorder , thereby ameliorating and/or preventing one or more symptoms of the autoimmune disorder , wherein the antibody comprises:a heavy chain variable region (VH) comprising CDR1, CDR2, and CDR3 of the VH region comprising the amino acid sequence shown in SEQ ID NO: 40; anda light chain variable region (VL) comprising CDR1, CDR2, and CDR3 of the VL region comprising the amino acid sequence shown in SEQ ID NO: 41.16. The method of claim 15 , wherein administration of the antagonist IL-7R antibody results in reduced naïve and activated T cell populations in the individual compared to before administration.17. The method of claim 16 , wherein the reduced T cell populations in the individual comprise T1 and/or T17 cells.18. A method of treating and/or preventing type 2 diabetes in an individual claim 16 , the method comprising administering a therapeutically effective amount of an antagonist IL-7R antibody to an individual suffering from or at risk for type 2 diabetes claim 16 , thereby ameliorating and/or preventing one or more symptoms of type 2 diabetes claim 16 , wherein antibody comprises:a heavy chain variable region (VH) comprising CDR1, CDR2, and CDR3 of the VH region comprising the amino acid ...

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07-07-2016 дата публикации

ENGINEERED POLYPEPTIDE CONJUGATES USING TRANSGLUTAMINASE

Номер: US20160193356A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof. 1. An engineered polypeptide conjugate comprising the formula: polypeptide-T-A , wherein T is an acyl donor glutamine-containing tag engineered at a specific site , wherein A is an amine donor agent , wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag at a carboxyl terminus , an amino terminus , or at an another site in the polypeptide , and wherein the acyl donor glutamine-containing tag comprises an amino acid sequence GGLLQGPP (SEQ ID NO:13).2. An engineered Fc-containing polypeptide conjugate comprising the formula: (Fc-containing polypeptide-T-A) , wherein T is an acyl donor glutamine-containing tag engineered at a specific site , wherein A is an amine donor agent , wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag at a carboxyl terminus , an amino terminus , or at an another site in the Fc-containing polypeptide , wherein the acyl donor glutamine-containing tag comprises an amino acid sequence XXQX (SEQ ID NO:35) , LLQ , or GLLQ (SEQ ID NO: 24) , wherein X is any amino acid , and wherein the engineered Fc-containing polypeptide conjugate comprises an amino acid substitution from glutamine to asparagine at position 295 (Q295N; EU numbering scheme).3. The engineered Fc-containing polypeptide conjugate of claim 2 , wherein the acyl donor glutamine-containing tag comprises an amino acid sequence selected from the group consisting of LLQGG (SEQ ID NO:16) claim 2 , LLQG (SEQ ID NO:17) claim 2 , LSLSQG (SEQ ID NO:18) claim 2 , GGGLLQGG (SEQ ID NO:19) claim 2 , GLLQG (SEQ ID NO:20) claim 2 , LLQ claim 2 , GSPLAQSHGG (SEQ ID NO:21) claim 2 , GLLQGGG ( ...

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11-08-2016 дата публикации

ANTAGONIST ANTI-IL-7 RECEPTOR ANTIBODIES AND METHODS

Номер: US20160229917A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus. 1. An isolated interleukin-7 receptor (IL-7R) antibody which specifically binds to interleukin-7 receptor alpha (IL-7Rα) and comprises an antigen binding region that cross-competes with a monoclonal antibody selected from the group consisting of P3A9 , P4B3 , P2D2 , P2E11 , HAL403a , HAL403b , C1GM and C2M3 , for binding to IL-7Rα.2. The antibody of claim 1 , wherein the antibody binds to an epitope comprising residues I82 claim 1 , K84 claim 1 , K100 claim 1 , T105 claim 1 , and Y192 of human IL-7Rα.3. An isolated antibody which specifically binds to interleukin-7 receptor alpha (IL-7Rα) claim 1 , wherein the antibody comprises a heavy chain variable region (VH) complementary determining region one (CDR1) having the amino acid sequence XXVMH claim 1 , wherein Xis D or N; Xis S or Y (SEQ ID NO: 50) claim 1 , a VH CDR2 having the amino acid sequence XXXXXGXXTYYADSVKG claim 1 , wherein Xis L or A; Xis V or I; Xis G or S; Xis W or G; Xis D or S; Xis F claim 1 , G or S; Xis F claim 1 , A or S (SEQ ID NO: 51) claim 1 , and a VH CDR3 having the amino acid sequence XXXXXXXX claim 1 , wherein Xis Q or D; Xis G or I; Xis D or S; Xis Y or G; Xis M claim 1 , V or G; Xis G or F; Xis N claim 1 , D or M; Xis N claim 1 , Y or D (SEQ ID NO: 52) claim 1 , a light chain variable region (VL) CDR1 having the amino acid sequence TXSSGXIXSSYVQ wherein Xis R or G; Xis S or R; Xis D or A (SEQ ID NO: 53) claim 1 , a VL CDR2 having the amino acid sequence EDXQRPS wherein Xis D or N (SEQ ...

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10-08-2017 дата публикации

METHODS FOR REDUCING LDL-CHOLESTEROL

Номер: US20170224816A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention relates to methods for the treatment of reducing LDL-cholesterol levels in a subject infected with hepatitis C virus (HCV) or at high risk of contracting HCV comprising administration to the subject in need thereof a therapeutically effective amount of an antagonist antibody which specifically binds to a human PCSK9 protein. The subject treatment can be used in the prevention and/or treatment of cholesterol and lipoprotein metabolism disorders, including hypercholesterolemia, dyslipidemia, hyperlipidemia, atherosclerosis, acute coronary syndrome and, more generally, cardiovascular disease (CVD). 1. A method of reducing a level of LDL-cholesterol in blood of a subject infected with hepatitis C virus (HCV) or at high risk of contracting HCV , comprising administering to the subject in need thereof a therapeutically effective amount of an antagonist antibody which specifically binds to a human proprotein convertase subtilisin kexin type 9 (PCSK9) of SEQ ID NO:1.2. The method of claim 1 , wherein the antibody blocks LDLR binding to the PCSK9 of SEQ ID NO: 1.3. The method of claim 1 , wherein the antibody is alirocumab (PRALUENT™) claim 1 , evolocumab (REPATHA™) claim 1 , REGN728 claim 1 , LGT209 claim 1 , RG7652 claim 1 , LY3015014 claim 1 , L1L3 claim 1 , 31H4 claim 1 , 11F1 claim 1 , 12H11 claim 1 , 300N claim 1 , 8A1 claim 1 , 8A3 claim 1 , 3C4 claim 1 , or 1D05.4. The method of claim 1 , wherein the antibody comprises a heavy chain variable region (VH) comprising complementarity determining region one (CDR1) claim 1 , CDR2 claim 1 , and CDR3 of the amino acid sequence shown in SEQ ID NO: 2; and a light chain variable region (VL) comprising CDR1 claim 1 , CDR2 claim 1 , and CDR3 of the amino acid sequence shown in SEQ ID NO: 3.5. The method of claim 1 , wherein the antibody comprises a VH CDR1 having the amino acid sequence shown in SEQ ID NO: 4 claim 1 , 5 claim 1 , or 6 claim 1 , a VH CDR2 having the amino acid sequence shown in SEQ ID NO:7 or ...

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13-11-2014 дата публикации

Anti-glucagon receptor antibodies and methods of use thereof

Номер: US20140335091A1
Принадлежит: Rinat Neuroscience Corp

The present invention provides antagonizing antibodies that bind to glucagon receptor and methods of using same. The anti-glucagon receptor antibodies can be used therapeutically to lower glucose levels in blood, and can be in the prevention and/or treatment of glucose-related disorders, including diabetes, hyperglycemia, hyperinsulinemia, impaired fasting glucose, impaired glucose tolerance, dyslipidemia, or metabolic syndrome.

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08-09-2016 дата публикации

Antibodies specific for trop-2 and their uses

Номер: US20160257746A1
Принадлежит: Rinat Neuroscience Corp

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.

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12-07-2007 дата публикации

Methods of treating Alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof

Номер: US20070160616A1
Принадлежит: Rinat Neuroscience Corp

Monoclonal antibodies directed against amyloid beta peptide and methods of using same for treatment and prevention of Alzheimer's disease and Down's syndrome are described.

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13-06-2017 дата публикации

Engineered polypeptide conjugates and methods for making thereof using transglutaminase

Номер: US9676871B2
Принадлежит: PFIZER INC, Rinat Neuroscience Corp

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.

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24-11-2020 дата публикации

Engineered polypeptide conjugates using transglutaminase

Номер: US10842881B2
Принадлежит: Rinat Neuroscience Corp

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.

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28-02-2007 дата публикации

Antibodies directed against amy-loid-beta peptide and methods using same

Номер: AP2007003890A0
Принадлежит: Rinat Neuroscience Corp

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31-10-2007 дата публикации

Antibodies directed against amyloid-beta peptide and methods using same

Номер: AP2007004217A0
Принадлежит: Rinat Neuroscience Corp

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17-09-2014 дата публикации

Antibodies specific for Trop-2 and their uses

Номер: CN104053672A
Принадлежит: Rinat Neuroscience Corp

本发明提供与滋养层细胞表面抗原2(Trop-2)特异性结合之抗体。本发明进一步提供包含抗体之抗体缀合物、编码抗体之核酸及获得抗体之方法。本发明还涉及使用这些抗体及Trop-2抗体缀合物以治疗与Trop-2表达有关之症状(例如癌,诸如结肠癌、食道癌、胃癌、头颈癌、肺癌、卵巢癌或胰癌)之治疗方法。

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10-04-2013 дата публикации

Antagonist anti-il-7 receptor antibodies and methods

Номер: CN103038254A
Автор: W·翟, 李丽芬, 林家扬
Принадлежит: Rinat Neuroscience Corp

本发明提供了结合白细胞介素-7受体(IL-7R)的拮抗性抗体。本发明进一步提供了获得这种抗体及抗体编码核酸的方法。本发明进一步涉及使用这些抗体及其抗原结合部分治疗和/或预防2型糖尿病和免疫疾病的治疗方法,所述免疫疾病包括1型糖尿病、多发性硬化、类风湿性关节炎、移植物抗宿主疾病及狼疮。

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29-06-2012 дата публикации

Anti-ngf antibodies and methods using same

Номер: SI1575517T1
Принадлежит: Rinat Neuroscience Corp

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16-01-2013 дата публикации

ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING

Номер: EP2545079A2
Принадлежит: PFIZER INC, Rinat Neuroscience Corp

The present invention relates to antibodies with pH dependent binding to its antigen such that the affinity for antigen binding at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6.0 or 5.5). In other words, the K D or k off ratio at pH 5.5/ pH 7.4 or at pH 6.0/ pH 7.4 is more than, or ranges between, 2, 3, 4, 8, 10, 16, 20, 30, 40, or 100 or more. Such pH dependent antibodies preferentially dissociate from the antigen in the endosome. This can increase antibody half life, as compared to antibodies with equivalent K D s at pH 7.4 but with no pH dependent binding, when the antigen is one that undergoes antigen-mediated clearance (e.g., PCSK9). Antibodies with pH dependent binding can decrease total antigen half life when the antigen undergoes reduced clearance when bound to antibody (e.g., IL6). Antibodies with pH dependent binding can also prolong the decrease in antigen which is not antibody-bound. This can be important when antagonizing a target antigen typically present at high levels (e.g., IgE, DKK1, C5 and SOST). In addition, such antibodies can increase antigen half life when the antigen is a receptor and the receptor has increased clearance when bound to antibody (e.g, GMCSF receptor).

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06-07-2006 дата публикации

Methods for treating cardiac arrhythmia and preventing death due to cardiac arrhythmia using ngf antagonists

Номер: US20060147450A1
Автор: David Shelton
Принадлежит: Rinat Neuroscience Corp

This invention relates to the field of cardiac disease. More specifically, the invention relates to methods using an NGF antagonist for treating and preventing cardiac arrhythmia and methods of preventing death due to cardiac arrhythmia.

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06-01-2005 дата публикации

Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same

Номер: WO2005000194A2
Принадлежит: RINAT NEUROSCIENCE CORP.

The invention features methods and compositions for preventing or treating post-surgical pain by administering an anti-NGF antagonist antibody.

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06-04-2006 дата публикации

Antibodies directed against amyloid-beta peptide and methods using same

Номер: WO2006036291A2
Принадлежит: RINAT NEUROSCIENCE CORP.

Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.

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09-02-2007 дата публикации

ANTIBODIES TARGETED AGAINST AMYLOID BETA PEPTIDE AND METHODS USING THEM

Номер: PE20061323A1
Принадлежит: Rinat Neuroscience Corp

SE REFIERE A UN ANTICUERPO MONOCLONAL SELECCIONADO DE IgG1, IgG2; IgG3 E IgG4 EL CUAL SE UNE A UN PEPTIDO AB, ESPECIFICAMENTE A UN EPITOPO EN AB1-40 QUE INCLUYE LOS AMINOACIDOS 25-34 Y 40 CON UNA AFINIDAD DE APROXIMADAMENTE DE 5nM O MENOS. DICHO ANTICUERPO COMPRENDE UNA REGION VARIBLE DE CADENA PESADA SELECCIONADA DE SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4 Y SEQ ID NO:5; Y UNA REGION VARIBLE DE CADENA LIGERA SELECCIONADA DE SEQ ID NO:2, SEQ ID NO:6, SEQ ID NO:7 Y SEQ ID NO:8. EL ANTICUERPO NO ES EL ANTICUERPO 2294. SON UTILES EN EL TRATAMIENTO DE ALZHEIMER REFERS TO A SELECTED MONOCLONAL ANTIBODY OF IgG1, IgG2; IgG3 AND IgG4 WHICH BIND WITH AN AB PEPTIDE, SPECIFICALLY TO AN EPITOPE AT AB1-40 INCLUDING AMINO ACIDS 25-34 AND 40 WITH AN AFFINITY OF APPROXIMATELY 5nM OR LESS. SAID ANTIBODY INCLUDES A HEAVY CHAIN VARIBLE REGION SELECTED FROM SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 4 AND SEQ ID NO: 5; AND A VARIBLE REGION OF LIGHT CHAIN SELECTED FROM SEQ ID NO: 2, SEQ ID NO: 6, SEQ ID NO: 7 AND SEQ ID NO: 8. THE ANTIBODY IS NOT THE 2294 ANTIBODY. THEY ARE USEFUL IN THE TREATMENT OF ALZHEIMER

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28-03-2012 дата публикации

ANTI-BODIES ANTAGONISTS ANTI RECEIVER OF IL-7 AND PROCEDURES

Номер: AR080291A1
Автор: [UNK]
Принадлежит: Rinat Neuroscience Corp

La presente solicitud proporciona anticuerpos antagonizantes que se unen al receptor de interleucina 7 (IL-7R). La solicitud proporciona adicionalmente un procedimiento para obtener tales anticuerpos y ácidos nucleicos que codifican los anticuerpos. La solicitud se refiere adicionalmente a procedimientos terapéuticos para el uso de estos anticuerpos y partes de union a antígeno de los mismos para el tratamiento y/o la prevencion de diabetes tipo 2 y trastornos inmunologicos, incluyendo diabetes tipo 1, esclerosis multiple, artritis reumatoide, enfermedad de injerto contra huésped y lupus. Reivindicacion 1: Un anticuerpo del receptor de interleucina 7 (IL-7R) aislado que se une específicamente a IL-7R y comprende una region de union a antígeno que compite de forma cruzada, con un anticuerpo monoclonal seleccionado del grupo que consiste en P3A9, P4B3, P2D2, P2E11, HAL403a, HAL403b, C1GM y C2M3, por la union a IL-7R. The present application provides antagonizing antibodies that bind to the interleukin 7 receptor (IL-7R). The application further provides a method for obtaining such antibodies and nucleic acids encoding the antibodies. The application further relates to therapeutic procedures for the use of these antibodies and antigen binding parts thereof for the treatment and / or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft versus host disease and lupus. Claim 1: An isolated interleukin 7 (IL-7R) receptor antibody that specifically binds to IL-7R and comprises a cross-antigen-binding region with a monoclonal antibody selected from the group consisting of P3A9, P4B3, P2D2, P2E11, HAL403a, HAL403b, C1GM and C2M3, by joining IL-7R.

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27-06-2013 дата публикации

Staphylococcus aureus specific antibodies and uses thereof

Номер: WO2013093693A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess.

Подробнее
13-11-2014 дата публикации

Anti-glucagon receptor antibodies and methods of use thereof

Номер: CA2911412A1
Принадлежит: Rinat Neuroscience Corp

The present invention provides antagonizing antibodies that bind to glucagon receptor and methods of using same. The anti-glucagon receptor antibodies can be used therapeutically to lower glucose levels in blood, and can be in the prevention and/or treatment of glucose-related disorders, including diabetes, hyperglycemia, hyperinsulinemia, impaired fasting glucose, impaired glucose tolerance, dyslipidemia, or metabolic syndrome.

Подробнее
18-06-2015 дата публикации

Anti-sclerostin antibodies

Номер: WO2015087187A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present disclosure provides antagonizing antibodies that specifically bind sclerostin. The disclosure further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The disclosure further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of bone related disorders, including, for example, multiple myeloma, osteoporosis, osteopenia, Paget's Disease, bone fracture, or bone loss. Methods of increasing bone formation, bone mass, bone volume, bone mineralization, bone quality, bone strength, or bone density as well as methods of inducing canonical Wnt signaling activity and methods of preventing or reducing tumor burden, methods of inhibiting or preventing tumor growth or progression, methods of inhibiting metastasis of cancer cells or tumors or delaying tumor growth or progression are also provided.

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11-02-2016 дата публикации

Methods for reducing ldl-cholesterol

Номер: WO2016020799A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention relates to methods for reducing LDL-cholesterol levels in blood comprising the administration of a combination of at least two different anti- PCSK9 antagonist antibodies or an anti-PCSK9 antagonist antibody (e.g., bispecific or bifunctional antibody) directed to different epitopes of PCSK9 protein. The subject single or combination treatment can be used in the prevention and/or treatment of cholesterol and lipoprotein metabolism disorders, including hypercholesterolemia, dyslipidemia, hyperlipidemia, atherosclerosis, acute coronary syndrome and, more generally, cardiovascular disease (CVD).

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08-01-2020 дата публикации

Anti-gitr antibodies and methods of use thereof

Номер: EP3589657A1
Принадлежит: Rinat Neuroscience Corp

The present invention provides antibodies that bind Glucocorticoid Induced Tumor necrosis factor Receptor family related protein (GITR) and methods of using same. The anti-GITR antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

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10-10-2012 дата публикации

Antagonist antibodies directed against calcitonin gene-related peptide and methods using same

Номер: CN101309704B
Принадлежит: Rinat Neuroscience Corp

本发明描述了通过施用抗CGRP拮抗剂抗体来预防或治疗CGRP相关病症如血管运动症状的方法,所述病症包括头痛(例如偏头痛、丛集性头痛和紧张性头痛)和热潮红。也描述了针对CGRP的拮抗剂抗体G1和来自G1的抗体。

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28-05-2019 дата публикации

Engineered polypeptide conjugates and methods for making thereof using transglutaminase

Номер: CA2930801C
Принадлежит: PFIZER INC, Rinat Neuroscience Corp

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.

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01-11-2012 дата публикации

ANTI NOTCH-1 ANTIBODIES

Номер: PE20121494A1
Принадлежит: Pfizer, Rinat Neuroscience Corp

SE REFIERE A UN ANTICUERPO O UNA PORCION DE UNION AL ANTIGENO DEL MISMO QUE SE UNE A NOTCH-1 QUE COMPRENDE: i) UNA REGION VARIABLE CDR1 DE LA CADENA PESADA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 18; ii) UNA REGION VARIABLE CDR2 DE LA CADENA PESADA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 19; iii) UNA REGION VARIABLE CDR3 DE LA CADENA PESADA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 20; iv) UNA REGION VARIABLE CDR1 DE LA CADENA LIVIANA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 12; v) UNA REGION VARIABLE CDR2 DE LA CADENA LIVIANA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 13; Y vi) UNA REGION VARIABLE CDR3 DE LA CADENA LIVIANA QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 14. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHO ANTICUERPO SIENDO UTIL EN EL TRATAMIENTO DE CANCER REFERS TO AN ANTIBODY OR AN ANTIGEN-BINDING PORTION OF THE SAME THAT IS JOINED TO NOTCH-1, INCLUDING: i) A HEAVY-DUTY CHAIN VARIABLE CDR1 REGION INCLUDING THE SEQ ID NO. 18 AMINO ACID SEQUENCE; ii) A VARIABLE REGION CDR2 OF THE HEAVY CHAIN INCLUDING THE SEQUENCE OF AMINO ACIDS OF SEQ ID No. 19; iii) A VARIABLE CDR3 REGION OF THE HEAVY CHAIN THAT INCLUDES THE SEQUENCE OF AMINO ACIDS OF SEQ ID NO 20; iv) A VARIABLE REGION CDR1 OF THE LIGHT CHAIN INCLUDING THE SEQUENCE OF AMINO ACIDS OF SEQ ID No. 12; v) A VARIABLE REGION CDR2 OF THE LIGHT CHAIN INCLUDING THE SEQUENCE OF AMINO ACIDS OF SEQ ID No. 13; AND vi) A CDR3 VARIABLE REGION OF THE LIGHT CHAIN THAT INCLUDES THE SEQ ID NUMBER 14 AMINO ACID SEQUENCE. ALSO REFERS TO A PHARMACEUTICAL COMPOSITION THAT CONTAINS SUCH ANTIBODY BEING USEFUL IN THE TREATMENT OF CANCER

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23-01-2019 дата публикации

Anti notch-1 antibodies

Номер: EP3431501A1
Принадлежит: PFIZER INC, Rinat Neuroscience Corp

This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the NotchI negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.

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28-04-2005 дата публикации

Methods for treating taxol-induced sensory neuropathy

Номер: US20050089521A1
Автор: David Shelton
Принадлежит: Rinat Neuroscience Corp

This invention relates to the field of taxol-induced neuropathy. More specifically, the invention relates to methods of treating taxol-induced sensory neuropathy comprising administration of agonist anti-trkC antibody for the treatment, prevention, and/or amelioration of a symptom of taxol-induced sensory neuropathy.

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04-04-2007 дата публикации

Methods for treating taxol-induced gut disorder

Номер: EP1620127A4
Автор: David L Shelton
Принадлежит: Rinat Neuroscience Corp

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13-06-2007 дата публикации

METHODS OF TREATMENT OF DISEASES OF THE LOWER MOTOR NEURONE AND COMPOSITIONS USED IN THE SAME

Номер: AR054260A1
Принадлежит: Rinat Neuroscience Corp

Métodos para el tratamiento, prevencion y/o disminucion de los síntomas relacionados con enfermedades de la neurona motora inferior (tales como la atrofia muscular espinal). Los métodos comprenden la administracion de un agonista de un anticuerpo anti-trkC. También se proveen composiciones y conjuntos de elementos (kits). Reivindicacion 1: Una composicion farmacéutica caracterizada porque comprende un anticuerpo agonista anti-trkC y un vehículo aceptable para el uso farmacéutico para tratar una enfermedad de las neuronas motoras inferiores en un individuo. Methods for the treatment, prevention and / or reduction of symptoms related to diseases of the lower motor neuron (such as spinal muscular atrophy). The methods comprise the administration of an agonist of an anti-trkC antibody. Compositions and sets of elements (kits) are also provided. Claim 1: A pharmaceutical composition characterized in that it comprises an anti-trkC agonist antibody and a vehicle acceptable for pharmaceutical use to treat a lower motor neuron disease in an individual.

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10-10-2017 дата публикации

high drug loading antibody-drug conjugates

Номер: BR112016024370A2
Принадлежит: Pfizer, Rinat Neuroscience Corp

a presente invenção fornece conjugados de anticorpo-fármaco mediados por transglutaminase com alta proporção de anticorpo-fármaco (dar) compreendendo 1) marcadores que contêm glutamina, glutaminas endógenas e/ou glutaminas endógenas tornadas reativas pela manipulação do anticorpo ou uma transglutaminase manipulada (por exemplo, com especificidade de substrato alterado); e 2) agentes doa-dores de amina que compreendem unidades doadoras de amina, ligantes e porções do agente, em que dar é de pelo menos cerca de 5. a invenção também se refere aos métodos de produção e métodos de uso de tais conjugados de anticorpo-fármaco altamente carregados de fármaco. The present invention provides high antibody-drug ratio (dar) transglutaminase mediated antibody-drug conjugates comprising 1) markers containing glutamine, endogenous glutamines and / or endogenous glutamines made reactive by antibody manipulation or a manipulated transglutaminase (e.g. , with altered substrate specificity); and 2) amine donor agents comprising amine donor units, binders and portions of the agent, wherein the donor is at least about 5. The invention also relates to methods of production and methods of using such conjugates of highly drug-loaded antibody-drug.

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19-10-2006 дата публикации

Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same

Номер: WO2006110883A2
Принадлежит: RINAT NEUROSCIENCE CORP.

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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16-09-2009 дата публикации

Methods for treating pain by administering an antagonist antibody against the nerve growth factor and an opioid analgesic, and compositions containing the same

Номер: EP2100902A1
Принадлежит: Rinat Neuroscience Corp

The present invention features methods for treating or preventing pain comprising administering an amount of an antagonist antibody against the nerve growth factor and an amount of an opioid analgesic such that together they provide effective pain relief. The invention also features compositions comprising an antagonist antibody against the nerve growth factor antagonist and an opioid analgesic and kits containing the same.

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02-06-2010 дата публикации

Method for treating pain by administering a nerve growth factor antagonist and an NSAID and composition containing the same

Номер: EP2191846A1
Принадлежит: Rinat Neuroscience Corp

The present invention features methods for treating or preventing pain comprising administering an amount of a nerve growth factor antagonist (such as an anti-NGF antibody) and an amount of an NSAID such that together they provide effective pain relief. The invention also features compositions comprising a nerve growth factor antagonist and an NSAID and kits containing the same.

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14-07-2010 дата публикации

Methods for treating bone cancer pain by administering a nerve growth factor antagonistic antibody

Номер: EP2206728A1

The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF) which is a humanised anti-NGF antibody that is capable of binding hNGF.

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22-12-2010 дата публикации

Anti-NGF antibodies and methods using same

Номер: EP2263692A1
Принадлежит: Rinat Neuroscience Corp

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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23-03-2011 дата публикации

Antibodies directed against amyloid-beta peptide and methods using same

Номер: EP2298807A2
Принадлежит: Rinat Neuroscience Corp

Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ; peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ; peptide associated diseases are also described.

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26-10-2011 дата публикации

Antagonist antibodies directed against calcitonin gene-related peptide and methods using same

Номер: EP2380592A2
Принадлежит: Rinat Neuroscience Corp

The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. Antagonist antibody G1 and antibodies derived from G1 directed to CGRP are also described.

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16-05-2013 дата публикации

Antibodies specific for trop-2 and their uses

Номер: WO2013068946A2
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.

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27-06-2013 дата публикации

Human growth hormone receptor antagonist antibodies and methods of use thereof

Номер: WO2013093707A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF-1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF-1, including treatment of acromegaly, gigantism, cancer, diabetic nephropathy, arthritis, and lung inflammation.

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13-11-2014 дата публикации

Anti-glucagon receptor antibodies and methods of use thereof

Номер: WO2014181229A2
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antagonizing antibodies that bind to glucagon receptor and methods of using same. The anti-glucagon receptor antibodies can be used therapeutically to lower glucose levels in blood, and can be in the prevention and/or treatment of glucose-related disorders, including diabetes, hyperglycemia, hyperinsulinemia, impaired fasting glucose, impaired glucose tolerance, dyslipidemia, or metabolic syndrome.

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16-06-2016 дата публикации

Anti-pd-1 antibodies and methods of use thereof

Номер: WO2016092419A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present discosure provides antagonizing antibodies that bind to programmed cell death protein 1 (PD-1) and methods of using same. The anti-PD-1 antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

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07-09-2018 дата публикации

Anti-gitr antibodies and methods of use thereof

Номер: WO2018158658A1
Принадлежит: RINAT NEUROSCIENCE CORP.

The present invention provides antibodies that bind Glucocorticoid Induced Tumor necrosis factor Receptor family related protein (GITR) and methods of using same. The anti-GITR antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

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05-01-2011 дата публикации

Anti-NGF antibodies and methods using same

Номер: EP2270048A2
Принадлежит: Rinat Neuroscience Corp

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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18-09-2019 дата публикации

Anti-ngf antibodies and methods using the same in treating pain associated with musculo-skeletal disorders

Номер: EP3539569A1
Принадлежит: Rinat Neuroscience Corp

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

Подробнее
18-05-2021 дата публикации

Anti-NGF antibodies and methods using same

Номер: US11008386B2
Принадлежит: Rinat Neuroscience Corp

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

Подробнее
04-01-2012 дата публикации

Agonist anti-trkC antibodies and methods using same

Номер: EP2402756A2
Автор: Jaume Pons
Принадлежит: Rinat Neuroscience Corp

The invention concerns agonist anti-trkC antibodies, polypeptides, and polynucleotides encoding the same. The invention further concerns use of such antibodies, polypeptides and/or polynucleotides in the treatment and/or prevention of neuropathies, such as sensory neuropathies, including taxol-induced sensory neuropathy, cisplatin-induced sensory neuropathy, and pyridoxine-induced sensory neuropathy.

Подробнее
12-09-2018 дата публикации

Methods for treating bone cancer pain by administering a nerve growth factor antagonist

Номер: EP3372614A1

The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as an anti-hNGF) antibody that is capable of binding hNGF.

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06-04-2011 дата публикации

Methods for treating osteoarthitis pain by administering a nerve growth factor antagonist and compositions containing the same

Номер: EP2305711A2
Принадлежит: Rinat Neuroscience Corp

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

Подробнее
24-01-2018 дата публикации

Methods for treating osteoarthitis pain by administering a nerve growth factor antagonist and compositions containing the same

Номер: EP3272358A1
Принадлежит: Rinat Neuroscience Corp

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

Подробнее
18-09-2008 дата публикации

Methods of treating ophthalmic diseases

Номер: WO2008110885A2
Автор: Chia-Yang Lin
Принадлежит: RINAT NEUROSCIENCE CORP.

Methods of using inhibitors (including monoclonal antibodies) directed against amyloid-beta peptide for the treatment of ophthalmic diseases such as age-related macular degeneration are described.

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22-01-2009 дата публикации

Methods of treating ophthalmic diseases

Номер: US20090022728A1
Автор: Chia-Yang Lin
Принадлежит: Rinat Neuroscience Corp

Methods of using inhibitors (including monoclonal antibodies) directed against amyloid-beta peptide for the treatment of ophthalmic diseases such as age-related macular degeneration are described.

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27-11-2018 дата публикации

Heterodimeric proteins and methods for producing and purifying them

Номер: US10138303B2
Принадлежит: Rinat Neuroscience Corp

The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

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17-08-2016 дата публикации

Antibodies directed against amyloid-beta peptide and methods using same

Номер: EP1877442B1
Принадлежит: Rinat Neuroscience Corp

Подробнее
02-01-2009 дата публикации

ANTAGONIST ANTIBODIES DIRECTED AGAINST CALCITONIN GENE-RELATED PEPTIDE AND METHODS USING THE SAME

Номер: MA30136B1
Принадлежит: Rinat Neuroscience Corp

Anticorps antagonistes dirigés contre le peptide apparenté au gène de calcitonine, et méthodes l'utilisant La présente invention a pour objet des méthodes pour la prévention et le traitement de troubles associés au CGRP tels que des symptômes vasomoteurs, y compris des céphalées (par exemple la migraine, les céphalées vasculaires de Horton et les céphalées dues à la tension) et les bouffées de chaleur, en administrant un anticorps antagoniste anti-CGRP. L'anticorps antagoniste G1 et des anticorps dérivés de G1 dirigés contre le CGRP sont également décrits.

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10-05-2012 дата публикации

Engineered polypeptide conjugates and methods for making thereof using transglutaminase

Номер: CA2813411A1
Принадлежит: PFIZER INC, Rinat Neuroscience Corp

The present invention provides engineered polypeptide conjugates (e.g., antibody- drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.

Подробнее
02-11-2006 дата публикации

Methods for treating lower motor neuron diseases and compositions for the same

Номер: CA2606196A1

This invention provides methods for the treatment, prevention, and/or amelioration of symptoms relating to lower motor neuron diseases (such as spinal muscular atrophy). The methods comprise administration of an agonist anti-trkC antibody. Compositions and kits are also provided.

Подробнее
22-04-2004 дата публикации

Methods for treating cardiac arrhythmia and preventing death due to cardiac arrhythmia using ngf antagonists

Номер: WO2004032852A2
Автор: David L. Shelton
Принадлежит: RINAT NEUROSCIENCE CORP.

This invention relates to the field of cardiac disease. More specifically, the invention relates to methods using an NGF antagonist for treating and preventing cardiac arrhythmia and methods of preventing death due to cardiac arrhythmia.

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04-08-2016 дата публикации

T cell receptor knock out engineered immune cells, endowed with chimeric antigen receptors binding to cd123 for the treatment of relapsed/refractory acute myeloid lymphoma or blastic plasmacytoid dendritic cell neoplasm

Номер: CA2973532A1
Принадлежит: CELLECTIS SA, Rinat Neuroscience Corp

The present invention relates to a TCRKO - or TCR KOand dCK KO - engineered immune cells expressing a Chimeric Antigen Receptors (CAR) specific for CD123 that is a recombinant chimeric protein able to redirect immune cell specificity and reactivity toward CD123-expressing cells, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CD123 CARs are particularly suited for treating relapse refractory AML and blastic plasmacytoid dendritic cell neoplasmand for use as a treatment before bone marrow transplantation.

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26-09-2019 дата публикации

Anti-ngf antibodies and methods using the same

Номер: IL218087B
Автор:
Принадлежит: Rinat Neuroscience Corp

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

Подробнее
15-08-2007 дата публикации

METHODS OF TREATMENT OF PAIN CAUSED BY OSTEOARTRITIS THROUGH THE ADMINISTRATION OF AN ANTAGONIST OF THE NEURONAL GROWTH FACTOR AND COMPOSITIONS CONTAINING IT

Номер: AR055323A1
Принадлежит: Rinat Neuroscience Corp

Anticuerpos anti-NGF (tales como anticuerpos de antagonistas anti-NGF), y polinucleotidos que los codifican. Uso de dichos anticuerpos y/o polinucleotidos en el tratamiento y/o prevencion del dolor, incluyendo el dolor, incluyendo el dolor post- quirurgico, el dolor de la artritis reumatoide y el dolor causado por la osteoartritis. Anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides that encode them. Use of said antibodies and / or polynucleotides in the treatment and / or prevention of pain, including pain, including post-surgical pain, rheumatoid arthritis pain and pain caused by osteoarthritis.

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02-01-2013 дата публикации

Antibodies with binding of ph dependent antigens.

Номер: CO6592103A2
Принадлежит: Pfizer, Rinat Neuroscience Corp

La presente invención se refiere a anticuerpos con unión dependiente de pH a su antígeno de tal forma que la afinidad de unión al antígeno a pH fisiológico (es decir, pH 7,4) es mayor que a pH endosómico (es decir, pH 6,0 o 5,5). En otras palabras, la proporción de Ko la proporción de ka pH 5,5/pH 7,4 o a pH 6,0/pH 7,4 es más de, ovaría entre, 2, 3, 4, 8, 10, 16, 20, 30, 40, o 100 o más. Tales anticuerpos dependientes de pH se disocian preferencialmente del antígeno en el endosoma. Esto puede incrementar la semivida del anticuerpo, en comparación con los anticuerpos con KD equivalentes a pH 7,4 pero con ninguna unión dependiente de pH, cuando el antígeno es uno que sufre la eliminación mediada por antígeno (por ejemplo, PCSK9). Los anticuerpos con unión dependiente de pH pueden disminuir la semivida de antígeno total cuando el antígeno sufre eliminación reducida cuando se une a anticuerpo (por ejemplo, 1L6). Los anticuerpos con unión dependiente de pH también pueden prolongar el decrecimiento en antígeno que no está unido a anticuerpo. Esto puede ser importante cuando se antagoniza un antígeno objetivo típicamente presente a niveles altos (por ejemplo, IgE, DKK1, C5 y SOST). Además, tales anticuerpos pueden incrementar la semivida de antígeno cuando el antígeno es un receptor y el receptor tiene eliminación incrementada cuando se une a anticuerpo (por ejemplo, receptor de GMCSF). The present invention relates to antibodies with pH-dependent binding to their antigen such that the affinity of binding to the antigen at physiological pH (i.e., pH 7.4) is greater than at endosomal pH (i.e., pH 6, 0 or 5.5). In other words, the proportion of Ko the proportion of ka pH 5.5 / pH 7.4 or pH 6.0 / pH 7.4 is more than, would vary between, 2, 3, 4, 8, 10, 16, 20, 30, 40, or 100 or more. Such pH-dependent antibodies preferentially dissociate from the antigen in the endosome. This may increase the half-life of the antibody, compared to antibodies with KD equivalent to pH 7.4 but ...

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02-11-2006 дата публикации

Methods for treating lower motor neuron diseases and compositions for the same

Номер: WO2006116609A2
Принадлежит: RINAT NEUROSCIENCE CORP.

This invention provides methods for the treatment, prevention, and/or amelioration of symptoms relating to lower motor neuron diseases (such as spinal muscular atrophy). The methods comprise administration of an agonist anti-trkC antibody. Compositions and kits are also provided.

Подробнее
31-10-2017 дата публикации

Anti-pd-1 antibodies

Номер: CO2017005738A2
Принадлежит: Rinat Neuroscience Corp

La presente invención se refiere a anticuerpos antagonistas que se fijan a la proteína de muerte celular programada 1 (PD-1) que comprenden una región variable de la cadena pesada (VH) que comprende una región determinante de la complementariedad uno (CDR1) de VH, CDR2 VH y CDR3 VH de la VH que tienen una secuencia de aminoácidos seleccionada del grupo que consiste en SEQ ID NO: 3, SEQ ID NO: 4; SEQ ID NO: 5; y SEQ ID NO: 6; y una región variable de la cadena liviana (VL) que comprende una CDR1 VL, CDR2 VL y CDR3 VL de la VL que tienen una secuencia de aminoácidos seleccionada del grupo que consiste en SEQ ID NO: 2; SEQ ID NO:7; SEQ ID NO: 8; y SEQ ID NO: 9; para el tratamiento, la prevención y/o el diagnóstico de distintas enfermedades, que incluyen enfermedades hiperproliferativas, tales como cáncer. The present invention relates to antagonistic antibodies that bind to programmed cell death protein 1 (PD-1) comprising a variable region of the heavy chain (VH) comprising a complementarity determining region one (CDR1) of VH , VH CDR2 and VH CDR3 having an amino acid sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 4; SEQ ID NO: 5; and SEQ ID NO: 6; and a light chain variable region (VL) comprising a VL CDR1, VL CDR2, and VL CDR3 VL having an amino acid sequence selected from the group consisting of SEQ ID NO: 2; SEQ ID NO: 7; SEQ ID NO: 8; and SEQ ID NO: 9; for the treatment, prevention and / or diagnosis of various diseases, including hyperproliferative diseases, such as cancer.

Подробнее
26-09-2016 дата публикации

Antibodies directed to amyloid beta peptide and methods for its use

Номер: DK1877442T3
Принадлежит: Rinat Neuroscience Corp

Подробнее
13-07-2017 дата публикации

T cell receptor knock out engineered immune cells, endowed with chimeric antigen receptors binding to CD123 for the treatment of relapsed/refractory acute myeloid lymphoma or blastic plasmacytoid dendritic cell neoplasm

Номер: AU2016212162A1
Принадлежит: CELLECTIS SA, Rinat Neuroscience Corp

The present invention relates to a TCRKO - or TCR KOand dCK KO - engineered immune cells expressing a Chimeric Antigen Receptors (CAR) specific for CD123 that is a recombinant chimeric protein able to redirect immune cell specificity and reactivity toward CD123-expressing cells, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CD123 CARs are particularly suited for treating relapse refractory AML and blastic plasmacytoid dendritic cell neoplasmand for use as a treatment before bone marrow transplantation.

Подробнее
15-07-2004 дата публикации

Anti-ngf antibodies and methods using same

Номер: CA2936742A1
Принадлежит: Rinat Neuroscience Corp

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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07-03-2013 дата публикации

PCSK9 antagonists

Номер: AU2013200743A1
Принадлежит: PFIZER INC, Rinat Neuroscience Corp

Abstract The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholes-terolemia.

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29-11-2006 дата публикации

Anti-ngf antibodies and methods using same

Номер: ZA200504866B
Принадлежит: Rinat Neuroscience Corp

The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.

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