FOAMED POLYURETHANE POLYMERS FOR THE REGENERATION OF CONNECTIVE TISSUE

The present invention relates to a method of synthesis and the use of foamed, cross-linked polyurethane polymers, as a three-dimensional support called a “scaffold” for cell cultures in vitro and for in vivo implantation for the regeneration of connective tissues such as adipose tissue, osteochondral tissue and bone tissue. In particular, the invention relates to a method of preparing polymers or foamed polyurethane co polymers, having improved , which involves the use of two types of catalyst, one for the cross-linking reaction and one for the foaming reaction and the use of at least one polar aprotic high-boiling solvent. Said method comprises the following steps in sequence: a) providing a solution of a polyol or a mixture of polyols in a solvent or mixture of solvents; b) heating the solution in step a) to a temperature higher than the softening temperature of the polymer precursors; c) optionally adding an organic or inorganic filler material; d) adding to the mixture in step c) an aliphatic poly-isocyanate or a mixture of poly-aliphatic isocyanates; e) adding to the mixture in step (d)) a porogenic additive; f) adding to the mixture in step e) simultaneously a cross-linking catalyst of polyols with poly-isocyanates and a foaming catalyst to form a foamed polyurethane polymer or co-polymer; g) isolating the foamed polyurethane polymer or co-polymer produced in step f). 1hydrophilia. A method for the preparation of polymer or co-polymer polyurethane foams with improved , which involves the use of a catalyst for the cross-linking reaction and a catalyst for the foaming reaction , comprising the following steps in sequence:a) providing a solution of a polyol or a mixture of polyols in a solvent or mixture of solvents, in which the solvent is a high-boiling solvent having a boiling point of at least 15° C. higher than the softening temperature of the polyols used;b) heating the solution in step a) to a temperature higher than the softening temperature of said ...

Foamed polyurethane polymers for the regeneration of connective tissue

The present invention relates to a method of synthesis and the use of foamed, cross-linked polyurethane polymers, as a three-dimensional support called a “scaffold” for cell cultures in vitro and for in vivo implantation for the regeneration of connective tissues such as adipose tissue, osteochondral tissue and bone tissue. In particular, the invention relates to a method of preparing polymers or foamed polyurethane co polymers, having improved hydrophilia, which involves the use of two types of catalyst, one for the cross-linking reaction and one for the foaming reaction and the use of at least one polar aprotic high-boiling solvent. Said method comprises the following steps in sequence: a) providing a solution of a polyol or a mixture of polyols in a solvent or mixture of solvents; b) heating the solution in step a) to a temperature higher than the softening temperature of the polymer precursors; c) optionally adding an organic or inorganic filler material; d) adding to the mixture in ...

METHOD FOR PRODUCING THREE-DIMENSIONAL MONOLITHIC MICROFLUIDIC DEVICES

Method for producing three-dimensional monolithic microfluidic devices

A method is described for producing a microfluidic device (19), which comprises the phases of producing a three-dimensional template (15) of geometry equal to the channelings that is desired to obtain in the device; inserting the template in the desired position into a mold (16), keeping it suspended by at least one of its end; coating said template by immersion in (or deposition of) a material in the liquid phase (or dissolved or dispersed in a solvent) capable of solidifying by means of a chemical reaction or physical transformation, forming a material constituting the body of the final device; and selectively removing the three-dimensional template. In a variant of the method, useful for the production of scaffolds to be inserted into the human body, a porogenic material is added to the liquid precursor or to the precursor solution, such that the material of the solid matrix is characterized by a continuous structure of pores into which it is possible to insert live cells.

METHOD FOR THE FABRICATION OF MONOLITHIC THREE-DIMENSIONAL MICROFLUIDIC DEVICES

Three-dimensional implantable matrix with reduced foreign body response

Three-dimensional implantable matrix with reduced foreign body response

Three-dimensional implantable matrix with reduced foreign body response