NIETWERKZEUG ZUM VERBINDEN VON BLECHEN.

Redundant pacing system with leaded and leadless pacing

A pacing system includes a controller operable to provide control signals indicating desired pacing signals, a pulse generator connected to the controller and operable to receive the control signals and to generate the desired pacing signals based on the control signals, at least one lead electrically connected to the pulse generator and extending into a user's heart and operable to provide the pacing signals to the heart, at least one electrode positioned in the user's heart and electrically connected to the at least one lead, the at least one electrode in contact with the user's heart and operable to stimulate the heart based on the pacing signals; and a transceiver, in communication with the pulse generator and operable to selectively transmit the pacing signals to the electrode wirelessly. The transceiver is controlled by the controller to transmit the pacing signals when pacing signals are not received by the electrode from the at least one lead. The lead may include multiple leads held together in a sugar moiety as a unitary body for insertion into the heart. Once in the heart, the sugar moiety dissolves to allow the leads to separate for implantation at different points in the heart.

Redundant pacing system with leaded and leadless pacing

A pacing system includes a controller operable to provide control signals indicating desired pacing signals, a pulse generator connected to the controller and operable to receive the control signals and to generate the desired pacing signals based on the control signals, at least one lead electrically connected to the pulse generator and extending into a user's heart and operable to provide the pacing signals to the heart, at least one electrode positioned in the user's heart and electrically connected to the at least one lead, the at least one electrode in contact with the user's heart and operable to stimulate the heart based on the pacing signals; and a transceiver, in communication with the pulse generator and operable to selectively transmit the pacing signals to the electrode wirelessly. The transceiver is controlled by the controller to transmit the pacing signals when pacing signals are not received by the electrode from the at least one lead. The lead may include multiple leads held together in a sugar moiety as a unitary body for insertion into the heart. Once in the heart, the sugar moiety dissolves to allow the leads to separate for implantation at different points in the heart.

Medical device system

A first portable medical device (10) is adapted for use in an interlocking system for interlocking the first medical device (12) to a second medical device (14). The first device includes a housing having opposite sides (17L, 17R), a selective element, a blocking element, and an optional clamp mechanism (22). At least one of the opposite sides includes a matable element (102) to detachably attach a second medical device. The selective element (106) restricts the attachment of the second device to only one side of the first device. The blocking element (112) prevents a third medical device from attaching to the first and second devices once the first and second devices are attached. The clamp (22) restricts the attachment of the second device to only one side of the first device when the clamp is attached to a support member. The clamp permits slide-ratcheting axial movement of a clamp shaft (34).

Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula (I) where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Remotely controlled catheter insertion system

Shielded surgical garment

A shielded head cover in accordance with an embodiment of the present application includes at least one attenuation portion including a radiation attenuating material configured and operable to protect a user head from radiation. The attenuation portion may include a varying amount of radiation attenuating material at different locations to provide for increased protection at desired locations. The attenuation portion may be embodied as a removable patch that is attached to the head cover. The attenuation portion may be provided by spraying particles of radiation attenuating material on the head cover. The attenuation portion may be embodied as a headband configured to be wrapped around a user's head and including attenuating material positioned in a pocket or cavity therein.

Coupling adapter and assembly

The present invention includes a pre-assembled, high-pressure coupling interface adapter (10) for use with a non-threaded port (28) of a female member (30). The adapter (10) comprises a generally cylindrically shaped metal body (12) including a central longitudinal channel (14) and an inner (16) and outer (18) surface. The body (12) includes an external segment (20) having an external end (22) and an internal segment (24) having an internal end (26), the internal segment (24) configured for receipt within the port (28) of the female member (30). The inner surface (16) of the body (12) is configured to engage and secure one or more external features of a separate male coupling member (46). The present invention also includes a coupling assembly (31) including a coupling adapter (10) and a method for forming a female coupling assembly (31) including an adapter (10).

Portable vibratory screed with bubble vial inclination indication system

A portable vibratory screed (10) includes a blade (12) that is connected to a handle (28) constructed to be manipulated by an operator. Nodes (112, 113, 115, 116) of minimum vibrational amplitude are formed at specific locations along the length of the blade when the exciter is driven at a rated operating speed. A site level (164) and/or the handle (28) is attached to the blade (12) at or in the vicinity of one or more of these nodes, therefore, is relatively isolated from induced vibrations.

Heterocyclic gpr40 modulators

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Meters for dynamics processing of audio signals

A gain reduction meter for dynamics processing provides information describing which part of a dynamics curve is affecting the input signal. In particular, the gain reduction meter displays an amount of gain reduction due to applying a dynamics processing operation in a manner that differentiates between gain reduction achieved by the different parts of the dynamics curve for that dynamics processing operation. The gain reduction meter has a plurality of display elements. Each display element corresponds to an amount of gain reduction. The illumination of the display elements is controlled such that the appearance of each illuminated display element is dependent on where on the dynamics curve the amount of gain reduction corresponding to that display element is produced.

Coupling assembly and retainer for use with same

A coupling assembly having male and female coupling members that are connectable and separable from each other. The coupling assembly utilizes a resiliently expandable locking element, which is provided on the male coupling member, to connect the male and female coupling members together by trapping the locking element, in its expanded position, between respective locking surfaces of the male and female coupling members. A locking sleeve, which is movable between unlocked and locked positions, is employed to move the locking element to its expanded position. In this position, the locking element prevents the withdrawal of the male coupling member from the female coupling member by creating a positive lock therebetween. To maintain the locking sleeve in its locked position, a retainer can be used.

Devices and methods for heart valve treatment

Devices and methods for improving the function of a valve (e.g., mitral valve) by positioning an implantable device outside and adjacent the heart wall such that the device alters the shape of the heart wall acting on the valve. The implantable device may alter the shape of the heart wall acting on the valve by applying an inward force and/or by circumferential shortening (cinching). The shape change of the heart wall acting on the valve is sufficient to change the function of the valve, and may increase coaptation of the leaflets, for example, to reduce regurgitation.

Self-contained multi-sprayer

A pressure sprayer (20) includes an accumulator vessel (142) adapted to hold a pressurized fluid therein and a container (68) that is configured to hold a chemical concentrate. A motor (156) in fluid communication with the accumulator vessel and the container (68) is adapted to be driven by the pressurized fluid and to pump the pressurized fluid and the chemical concentrate. A chamber (194) is adapted to receive the chemical concentrate and the pressurized fluid from the motor (156) to form a chemical solution. A nozzle is in fluid communication with the chamber (194).

Butt joint bracket

Stiffened surface micromachined structures and process for fabricating the same

Stiffened surface micromachined structures and a method to fabricate the same. A silicon substrate (10) is first etched to produce a mold containing a plurality of trenches or grooves (14) in a lattice configuration. Sacrificial oxide (15) is then grown on the silicon substrate (10) and then a stiffening member (16) (silicon nitride) is deposited over the surface of the substrate, thereby backfilling the grooves with silicon nitride. The silicon nitride is patterned to form mechanical members and metal (40) is then deposited and patterned to form the leads and capacitors for electrostatic actuation of mechanical members. The underlying silicon and sacrificial oxides are removed by etching the mold from underneath the fabricated micromachined devices, leaving free-standing silicon nitride devices with vertical ribs. The devices exhibit increased out-of-plan bending stiffness because of the presence of stiffening ribs. Silicon nitride biaxial pointing mirrors with stiffening ribs are also described.

Reinforcement restraint mechanism for a façade panel

System and method for managing risk associated with a transaction

A system and method for managing the risk associated with a wide variety of commercial transactions (12, 16, 22) involving a borrower, a lender and/or a third party with terms of a contract involving the purchase of a specified amount of stock.

Rxfp1 agonists

Predicting metabolic stability of drug molecules

Methods are disclosed for developing models used to rapidly predict metabolic stability and regioselectivity of drug molecules. Training sets, based on a sample of molecules with known reaction rates and/or activation energies, are used along with structural descriptors of the molecules in order to develop mathematical models of metabolism based on regression analysis of the activation energies and descriptors. The resulting models are then used to predict the metabolism of other molecules. The invention is particularly useful in developing simple models of cytochrome p450 enzyme metabolism.

Regenerator control

Ceiling trap

Predicting metabolic stability of drug molecules

Methods are disclosed for developing models used to rapidly predict metabolic stability and regioselectivity of drug molecules. Training sets, based on a sample of molecules with known reaction rates and/or activation energies, are used along with structural descriptors of the molecules in order to develop mathematical models of metabolism based on regression analysis of the activation energies and descriptors. The resulting models are then used to predict the metabolism of other molecules. The invention is particularly useful in developing simple models of cytochrome p450 enzyme metabolism.

Cyp2c9 binding models

Computer models described herein predict the binding affinity of compounds with the 2C9 isoform of the Cytochrome p450 family of enzymes. The models predict Ki or pKi for arbitrary compounds. They accomplish this by using selected molecular properties of the compound in question. Numeric values of these properties (also called descriptors) are received by the model. Execution of the model performs a calculation based on these descriptors and returns a value of binding affinity. The descriptors may include a measure of lipophilicity, a measure of aromaticity, and a measure of partial negative charge on the compound.

Male coupling for connecting to female threaded coupling

A coupling assembly including first and second members arrangeable between uncoupled and coupled positions. The first member has a receiving portion sized to receive at least a portion of the second member and internal threads provided therein. The second member has an exterior surface. A ratcheting locking member is disposed about the exterior surface of the second member and configured to move between locking and releasing positions. The ratcheting locking member is also biased to the locking position and has a retaining formation configured to mesh with and engage the internal threads of the first member. Upon insertion of the second member into the first member, the retaining formation of the ratcheting locking member progressively engages the internal threads of the first member, thereby locking the first and second members together.

Method and apparatus for single-photon source and quantum memory

An optical switch and optical storage loop are used as the basis of a single-photon source and a quantum memory for photonic qubits. To operate as a single-photon source, the techniques include a source [250] of a pair of photons, such as a parametric down-conversion crystal, which is known to emit photons in pairs. The detection of one member of the pair activates the switch, which re-routes the other member into the storage loop [240]. The stored photon is then known to be circulating in the loop, and can be switched out of the loop at a later time chosen by the user, providing a single photon [210d] for potential use in a variety of quantum information processing applications. To operate as a quantum memory for photonic qubits, a single-photon in an arbitrary initial polarization state is coherently stored in the loop, and coherently switched out of the loop when needed

Hämodynamisch reagierendes system zur behandlung eines in seiner funktion gestörten herzens.

Hemodynamic optimization system for biventricular implants

A system for monitoring a patient (100) and treating the malfunctioning heart of the patient, either in an automatic mode or in a semiautomatic mode, includes means which derive at least one physiologic signal from or related to the patient's circulatory system representative of hemodynamic status. A feedback loop is implemented in a biventricular implant, in order to automatically or selectively optimize the patient's clinical hemodynamic status. Accordingly, the biventricular implant will be programmed to go through a series of AV delay (155), RV-LV timing (110) and heart rate (130) sequences which scan a preselected range of programmable values and apply those values to the patient's heart. Hemodynamic patient measurements will be recorded and preferably graphed over those applied values. The optimal AV delay (165), RV-LV timing sequence (120) and pacing rate (140) can then be selected either manually by a technician, physician or other operator, or automatically via the implant in order to secure the best personalized timing sequence for the patient Preferably, the implant will also be capable of automatically recording hemodynamic information and adjusting intervals, in order to optimize hemodynamica without third party intervention. Also preferably, the automatic adjusting feature can be selectively programmed on or off using the device programmer, to control manual or automatic intervention.