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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 35. Отображено 35.
26-02-2004 дата публикации

RF front-end for dual-mode wireless LAN module

Номер: US20040038660A1
Принадлежит:

A dual-mode Wireless Local Area Network (WLAN) module installed in an electronic device (600) for wireless communication with other electronic devices includes an RF front-end unit (30), two dual-band antennas (40) coupled to the RF front-end unit, a dual-band radio frequency integrated circuit (RFIC) (20) coupled to the RF front-end unit, a dual-band base-band integrated circuit (BBIC) (10) coupled to the RFIC, and an interface unit coupled to both the BBIC and a computer (600). The RF front-end consists of transmitting and receiving paths. The RF front-end unit has antenna diversity control switching circuits (31, 33) for selecting an appropriate antenna and switching circuits (32, 34, 35, 36) for controlling ON/OFF states of transmitting/receiving paths of the RF front-end unit.

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04-05-2004 дата публикации

RJ connector for transceiver module

Номер: US0006731510B1

A small form factor pluggable transceiver module (100) comprises an RJ connector (1), a printed circuit board assembly (2), an engaging clamp (3), a cage (4), a frame (5) and a latching mechanism (6). The RJ connector attaches to the printed circuit board assembly. The engaging clamp engages both with the RJ connector and the printed circuit board assembly to strengthen the connection between the RJ connector and the printed circuit board assembly.

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06-07-2004 дата публикации

RJ connector with robust connector assembly for transceiver module

Номер: US0006758699B1

A small form factor pluggable transceiver module (100) comprises an RJ connector (1) with a robust interface, a printed circuit board assembly (2), a cage (4), a frame (5) and a latch mechanism (6). The RJ connector further includes a shielding shell (11), a housing (12) received in the shielding shell, an RJ contact module (13) received in the housing, and an engaging clamp (3). The RJ connector attaches to the printed circuit board assembly. The engaging clamp provides a stronger, more reliable mechanical connection between the printed circuit board assembly and the RJ connector.

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13-01-2004 дата публикации

Small form factor pluggable packaging

Номер: US000D485238S1
Принадлежит: Hon Hai Precision Ind. Co., Ltd.

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07-10-2004 дата публикации

RF front-end of dual-mode wireless transciver

Номер: US20040198420A1
Принадлежит:

A dual-mode WLAN module includes two dual-band antennas (43a, 43b), an RF front-end circuit (4), a dual-mode radio frequency integrated circuit (RFIC) chip (3), a dual-mode Base-Band integrated circuit chip (2), and an interface (mini-PCI, PCI, USB etc.) connecting to a computer (1). The RF front-end circuit for dual-mode WLAN module comprises two transmitting circuits, two receiving circuits, switch units, and logic control circuit (40) for controlling the operation of transmitting/receiving selection and antenna diversity selection.

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13-01-2004 дата публикации

SFP packaging with a pull-tab

Номер: US000D485237S1
Принадлежит: Hon Hai Precision Ind. Co., Ltd.

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22-11-2001 дата публикации

Predicting metabolic stability of drug molecules

Номер: US20010044699A1
Принадлежит:

Methods are disclosed for developing models used to rapidly predict metabolic stability and regioselectivity of drug molecules. Training sets, based on a sample of molecules with known reaction rates and/or activation energies, are used along with structural descriptors of the molecules in order to develop mathematical models of metabolism based on regression analysis of the activation energies and descriptors. The resulting models are then used to predict the metabolism of other molecules. The invention is particularly useful in developing simple models of cytochrome p450 enzyme metabolism.

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04-04-2002 дата публикации

Accessibility correction factors for electronic models of cytochrome P450 metabolism

Номер: US20020040276A1
Принадлежит: Camitro Corporation

Accessibility correction factors may be used to modify values predicted by models of electronic component substrate reactivity. Most of the correction factors described herein pertain to either steric or orientation effects on substrate accessibility. The correction factors may be derived from one or more “descriptors” of the substrate structure. Each group of descriptors and associated correction factor pertain to a particular site on the substrate. Examples of such descriptors include site polarity, protrusion, partial surface area, partial charge, etc. Often the correction factor is a function of multiple descriptors. The function may be an expression comprising multiple terms, each representing the weighted contribution of a particular descriptor. In other embodiments, the correction factor is simply a descriptor or a descriptor multiplied by a coefficient or other function.

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07-09-2004 дата публикации

Pluggable transceiver module having release mechanism

Номер: US0006786653B1

A transceiver module (1) having a release mechanism includes a connector assembly (3), a driving device (43), and a pull tab (45). The connector assembly includes a tab (362) for being received in a hole (242) of a bendable portion (240) of a receptacle (2), which receptacle receives the transceiver module therein. The driving device includes, a release member (42) and a wedge member (46). Both the pull tab and the wedge member are mechanically linked to the release member. When the pull tab is pulled outwardly, the release member rotates with respect to the connector assembly, driving the wedge member to press against the bendable portion of the receptacle, thus disengaging the tab from the hole. The transceiver module is then easily withdrawn from the receptacle. This arrangement allows the transceiver modules to be closely stacked together while still being readily accessible. This advantage decreases a stacking height of multiple transceiver modules.

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09-01-2014 дата публикации

METHOD AND APPARATUS FOR PREPPING BORES AND CURVED INNER SURFACES WITH A ROTATING HIGH-FREQUENCEY FORCED PULSED WATERJET

Номер: US20140008453A1
Принадлежит: VLN Advanced Technologies Inc.

A method of prepping a cylindrical inner surface of a bore using a high-frequency forced pulsed waterjet apparatus entails generating a pressurized waterjet using a high-pressure water pump, generating a high-frequency signal using a high-frequency signal generator, applying the high-frequency signal to a transducer having a microtip to cause the microtip to vibrate to thereby generate the high-frequency forced pulsed waterjet, and rotating the rotatable ultrasonic nozzle inside the bore to prep the inner cylindrical surface of the bore using the high-frequency forced pulsed waterjets exiting from the angled exit orifices of the rotatable ultrasonic nozzle. 1. A high-frequency forced pulsed waterjet apparatus comprising:a high-pressure water pump for generating a pressurized waterjet;a high-frequency signal generator for generating a high-frequency signal; anda rotatable ultrasonic nozzle comprising a transducer having a microtip for converting the high-frequency signal into vibrations that pulse the pressurized waterjet and two angled exit orifices for prepping an inner cylindrical surface of a bore into which the nozzle is inserted.2. The high-frequency forced pulsed waterjet apparatus as claimed in wherein the rotatable ultrasonic nozzle comprises two forwardly angled exit orifices and two rearwardly angled exit orifices.3. The high-frequency forced pulsed waterjet apparatus as claimed in wherein the rotatable ultrasonic nozzle comprises an inside forward end that is rounded or bell-mouthed.4. The high-frequency forced pulsed waterjet apparatus as claimed in wherein the rotatable ultrasonic nozzle comprises an inside forward end that is rounded or bell-mouthed.5. The high-frequency forced pulsed waterjet apparatus as claimed in wherein the rotatable ultrasonic nozzle comprises an entry zone proximal to each angled exit orifice that is rounded or bell-mouthed.6. The high-frequency forced pulsed waterjet apparatus as claimed in wherein the rotatable ultrasonic ...

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09-02-2017 дата публикации

INTEGRATED FLUIDJET SYSTEM FOR STRIPPING, PREPPING AND COATING A PART

Номер: US20170036239A1
Принадлежит:

An integrated liquidjet system capable of stripping, prepping and coating a part includes a cell defining an enclosure, a jig for holding the part inside the cell, an ultrasonic nozzle having an ultrasonic transducer for generating a pulsed liquidjet, a coating particle source for supplying coating particles to the nozzle, a pressurized liquid source for supplying the nozzle with a pressurized liquid to enable the nozzle to generate the pulsed liquidjet to sequentially strip, prep and coat the part, a high-voltage electrode and a ground electrode inside the nozzle for charging the coating particles, and a human-machine interface external to the cell for receiving user commands and for controlling the pulsed liquidjet exiting from the nozzle in response to the user commands. 1. An integrated liquidjet system capable of stripping , prepping and coating a part , the integrated liquidjet system comprising:a cell defining an enclosure;a jig for holding the part inside the cell;an ultrasonic nozzle having an ultrasonic transducer for generating a pulsed liquidjet;a coating particle source for supplying coating particles to the nozzle;a pressurized liquid source for supplying the nozzle with a pressurized liquid to enable the nozzle to generate the pulsed liquidjet to sequentially strip, prep and coat the part;a high-voltage electrode and a ground electrode inside the nozzle for charging the coating particles; anda human-machine interface external to the cell for receiving user commands and for controlling the pulsed liquidjet exiting from the nozzle in response to the user commands.2. The system as claimed in wherein the cell defines an electrically shielded enclosure.3. The system as claimed in wherein the cell includes a Faraday cage.4. The system as claimed in wherein the pulsed liquidjet is a forced pulsed waterjet5. The system as claimed in wherein the jig comprises a turntable for rotating the part at an angular velocity controlled by the human-machine interface.6. ...

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15-02-2018 дата публикации

INTEGRATED FLUIDJET SYSTEM FOR STRIPPING, PREPPING AND COATING A PART

Номер: US20180043394A1
Принадлежит:

An integrated liquidjet system capable of stripping, prepping and coating a part includes a cell defining an enclosure, a jig for holding the part inside the cell, an ultrasonic nozzle having an ultrasonic transducer for generating a pulsed liquidjet, a coating particle source for supplying coating particles to the nozzle, a pressurized liquid source for supplying the nozzle with a pressurized liquid to enable the nozzle to generate the pulsed liquidjet to sequentially strip, prep and coat the part, a high-voltage electrode and a ground electrode inside the nozzle for charging the coating particles, and a human-machine interface external to the cell for receiving user commands and for controlling the pulsed liquidjet exiting from the nozzle in response to the user commands. 1. A method of stripping , prepping and coating a part , the method comprising:holding the part inside a cell that defines an electrically shielded enclosure;generating a pulsed liquidjet using an ultrasonic nozzle;supplying coating particles to the nozzle;supplying the nozzle with a pressurized liquid to enable the nozzle to generate the pulsed liquidjet to sequentially strip, prep and coat the part;charging the coating particles using a high-voltage electrode and a ground electrode inside the nozzle;stripping the part by controlling the pulsed liquidjet;prepping the part by controlling the pulsed liquidjet; andcoating the part by controlling the pulsed liquidjet.2. The method as claimed in further comprising optically inspecting the part to determine when stripping is complete and then automatically switching to prepping.3. The method as claimed in further comprising detecting when prepping is complete and then automatically switching to coating.4. The method as claimed in further comprising detecting when coating is complete.5. A method of stripping claim 3 , prepping and coating a part claim 3 , the method comprising:generating a pulsed liquidjet using an ultrasonic nozzle that ultrasonically ...

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25-04-2019 дата публикации

METHOD AND APPARATUS FOR PREPPING BORES AND CURVED INNER SURFACES WITH A ROTATING HIGH-FREQUENCY FORCED PULSED WATERJET

Номер: US20190118211A1
Принадлежит:

A method of prepping a cylindrical inner surface of a bore using a high-frequency forced pulsed waterjet apparatus entails generating a pressurized waterjet using a high-pressure water pump, generating a high-frequency signal using a high-frequency signal generator, applying the high-frequency signal to a transducer having a microtip to cause the microtip to vibrate to thereby generate the high-frequency forced pulsed waterjet, and rotating the rotatable ultrasonic nozzle inside the bore to prep the inner cylindrical surface of the bore using the high-frequency forced pulsed waterjets exiting from the angled exit orifices of the rotatable ultrasonic nozzle. 1. A method of prepping a cylindrical inner surface of a bore using a high-frequency forced pulsed waterjet , the method comprising:inserting the nozzle inside the bore;generating a pressurized waterjet using a high-pressure water pump;generating a high-frequency signal using a high-frequency signal generator;applying the high-frequency signal to a transducer to generate the high-frequency forced pulsed waterjet; androtating a rotatable nozzle head inside the bore to prep the inner cylindrical surface of a substrate material of the bore to a predetermined uniform surface finish characterized by an average surface roughness Ra that is within a predetermined range of surface roughness using the high-frequency forced pulsed waterjet exiting from at least one angled exit orifice of the rotatable nozzle head, wherein the waterjet flows through a curved conduit in the nozzle head to the at least one angled exit orifice that is substantially perpendicular to an axis of rotation of the rotatable nozzle head to direct the waterjet radially outwardly against the surface of the bore.2. The method as claimed in further comprising translating the rotatable nozzle head forwardly and rearwardly inside the bore such that an erosive capacity in a forward pass is greater than an erosive capacity in a rearward pass.3. The method as ...

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11-09-2014 дата публикации

Method and apparatus for prepping bores and curved inner surfaces with a rotating high-frequencey forced pulsed waterjet

Номер: US20140252107A1
Принадлежит: VLN Advanced Technologies Inc

A method of prepping a cylindrical inner surface of a bore using a high-frequency forced pulsed waterjet apparatus entails generating a pressurized waterjet using a high-pressure water pump, generating a high-frequency signal using a high-frequency signal generator, applying the high-frequency signal to a transducer having a microtip to cause the microtip to vibrate to thereby generate the high-frequency forced pulsed waterjet, and rotating the rotatable ultrasonic nozzle inside the bore to prep the inner cylindrical surface of the bore using the high-frequency forced pulsed waterjets exiting from the angled exit orifices of the rotatable ultrasonic nozzle.

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05-11-2015 дата публикации

INTEGRATED FLUIDJET SYSTEM FOR STRIPPING, PREPPING AND COATING A PART

Номер: US20150315714A1
Принадлежит:

A method of stripping, prepping and coating a surface includes first stripping the exiting coating from a surface, using continuous or pulsed fluid jet, followed by prepping the surface by the same fluid jet. The method also provides entraining particles into a fluid stream, if desired to generate a particle-entrained fluid stream that is directed at the surface to be stripped and prepped. The particles act as abrasive particles for prepping the surface to a prescribed surface roughness required for subsequent application of a coating to the surface. The method then entails coating the surface by electrically charging particles having the same chemical composition as the particles used to prep the surface. Finally, a charged-particle-entrained fluid stream is directed at high speed at the charged surface to coat the surface. The particles form both mechanical and electronic bonds with the surface. 1. An integrated fluidjet system for sequentially stripping , prepping and coating a part to be refurbished , the integrated system comprising:a cell defining an electrically shielded enclosure and having a door;a jig for holding the part inside the cell;a robotic arm movable within the cell;a nozzle mounted on the robotic arm;a pressurized fluid source for supplying a pressurized fluid to the nozzle to enable the nozzle to generate a fluidjet capable of sequentially stripping, prepping and coating the part;an electric field generator for generating an electric field for charging the coating particles; anda human-machine interface external to the cell for receiving user commands and for controlling the robotic arm and fluidjet exiting from the nozzle in response to the user commands.2. The system as claimed in further comprising a magnetic field generator for generating a magnetic field for keeping the particles cohesive and focused to enhance impact of the coating particles on the surface.3. The system as claimed in further comprising an induction heater for heating the ...

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24-11-2016 дата публикации

INTEGRATED FLUIDJET SYSTEM FOR STRIPPING, PREPPING AND COATING A PART

Номер: US20160339460A1
Принадлежит:

A method of stripping, prepping and coating a surface comprises first stripping the exiting coating from a surface, using continuous or pulsed fluid jet, followed by prepping the surface by the same fluid jet. The method also provides entraining particles into a fluid stream, if desired to generate a particle-entrained fluid stream that is directed at the surface to be stripped and prepped. The particles act as abrasive particles for prepping the surface to a prescribed surface roughness required for subsequent application of a coating to the surface. The method then entails coating the surface by electrically charging particles having the same chemical composition as the particles used to prep the surface. Finally, a charged-particle-entrained fluid stream is directed at high speed at the charged surface to coat the surface. The particles form both mechanical and electronic bonds with the surface. 1. An integrated fluidjet system capable of prepping and coating a new part , the integrated system comprising:a cell defining an enclosure and having a door;a jig for holding the part inside the cell;a robotic arm movable within the cell;a nozzle mounted on the robotic arm;a coating particle source for supplying coating particles to the nozzle;a pressurized fluid source for supplying the nozzle with a pressurized fluid to enable the nozzle to generate a fluidjet with the coating particles particles and the pressurized fluid capable of sequentially prepping and coating the part;an electric field generator for generating an electric field for charging the coating particles; anda human-machine interface external to the cell for receiving user commands and for controlling the robotic arm and fluidjet exiting from the nozzle in response to the user commands.2. The system as claimed in further comprising a magnetic field generator for generating a magnetic field for keeping the particles cohesive and focused to enhance impact of the coating particles on the surface.3. The ...

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21-02-2017 дата публикации

Method and apparatus for prepping surfaces with a high-frequency forced pulsed waterjet using a rotatable nozzle

Номер: CA2880203C
Принадлежит: VLN Advanced Technologies Inc

A method of prepping a surface using a high-frequency forced pulsed waterjet entails generating a high-frequency signal having a frequency f using a high-frequency signal generator, applying the high-frequency signal to a transducer having a microtip to cause the microtip of the transducer to vibrate to thereby generate a forced pulsed waterjet through an exit orifice of a nozzle having an exit orifice diameter d and a length L. The forced pulsed waterjet prepares the surface to within a predetermined range of surface roughness. The surface roughness is determined by selecting operating parameters comprising a standoff distance (SD), a traverse velocity V TR of the nozzle, a water pressure P, a water flow rate Q, a length-to-diameter (L/d) ratio, a microtip-to-orifice distance (a), the frequency f, and an amplitude A of the high-frequency signal.

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11-02-2014 дата публикации

Method and apparatus for prepping surfaces with a high-frequency forced pulsed waterjet

Номер: CA2672441C
Принадлежит: VLN Advanced Technologies Inc

A method of prepping a surface using a high-frequency forced pulsed waterjet entails generating a high-frequency signal having a frequency f using a high-frequency signal generator, applying the high-frequency signal to a transducer having a microtip to cause the microtip of the transducer to vibrate to thereby generate a forced pulsed waterjet through an exit orifice of a nozzle having an exit orifice diameter d and a length L. The forced pulsed waterjet prepares the surface to within a predetermined range of surface roughness. The surface roughness is determined by selecting operating parameters comprising a standoff distance (SD), a traverse velocity V TR of the nozzle, a water pressure P, a water flow rate Q, a length-to-diameter (L/d) ratio, a microtip-to--orifice distance (a), the frequency f, and an amplitude A of the high-frequency signal.

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19-07-2017 дата публикации

Method and apparatus for prepping surfaces with a high-frequency forced pulsed waterjet

Номер: EP2540401A3
Принадлежит: VLN Advanced Technologies Inc

A method of prepping a surface using a high-frequency forced pulsed waterjet apparatus (10) comprises the steps of: generating a high-frequency signal having a frequency f using a high-frequency signal generator (20), applying the high-frequency signal to a transducer (60) having a microtip (70) to cause the microtip (70) of the transducer (60) to vibrate to thereby generate a forced pulsed waterjet through an exit orifice (80) of a nozzle (40) having an exit orifice (80) diameter d and a length L. The forced pulsed waterjet prepares the surface to within a predetermined range of surface roughness. The surface roughness is determined by selecting operating parameters comprising a standoff distance (SD), a traverse velocity V TR of the nozzle (40), a water pressure P, a water flow rate Q, a length-to-diameter (L/d) ratio, a microtip-to-orifice distance (a), the frequency f, and an amplitude A of the high-frequency signal.

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24-10-2017 дата публикации

Integrated fluidjet system for stripping, prepping and coating a part

Номер: CA2870682C
Принадлежит: VLN Advanced Technologies Inc

A method of stripping, prepping and coating a surface comprises first stripping the exiting coating from a surface, using continuous or pulsed fluid jet, followed by prepping the surface by the same fluid jet. The method also provides entraining particles into a fluid stream, if desired to generate a particle-entrained fluid stream that is directed at the surface to be stripped and prepped. The particles act as abrasive particles for prepping the surface to a prescribed surface roughness required for subsequent application of a coating to the surface. The method then entails coating the surface by electrically charging particles having the same chemical composition as the particles used to prep the surface. Finally, a charged- particle-entrained fluid stream is directed at high speed at the charged surface to coat the surface. The particles form both mechanical and electronic bonds with the surface.

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28-05-2019 дата публикации

Integrated fluidjet system for coating a part

Номер: CA2935137C
Принадлежит: VLN Advanced Technologies Inc

A fluidjet system for electro-coating a surface of a part includes a jig for holding the part and a nozzle having a water inlet for receiving pressurized water and a particle inlet for receiving coating particles, the nozzle entraining the coating particles into a mixing chamber to generate a particle-entrained fluidjet capable of coating the surface of the part. The system includes an electric field generator for generating an electric field downstream of the nozzle to thereby charge the coating particles passing through the electric field, wherein the electric field generator comprises a switch for activating and deactivating the electric field.

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16-01-2011 дата публикации

Method and apparatus for prepping surfaces with a high-frequency forced pulsed waterjet using a rotatable nozzle

Номер: CA2880203A1
Принадлежит: VLN Advanced Technologies Inc

A method of prepping a surface using a high-frequency forced pulsed waterjet entails generating a high-frequency signal having a frequency f using a high-frequency signal generator, applying the high-frequency signal to a transducer having a microtip to cause the microtip of the transducer to vibrate to thereby generate a forced pulsed waterjet through an exit orifice of a nozzle having an exit orifice diameter d and a length L. The forced pulsed waterjet prepares the surface to within a predetermined range of surface roughness. The surface roughness is determined by selecting operating parameters comprising a standoff distance (SD), a traverse velocity V TR of the nozzle, a water pressure P, a water flow rate Q, a length-to-diameter (L/d) ratio, a microtip-to-orifice distance (a), the frequency f, and an amplitude A of the high-frequency signal.

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24-08-2017 дата публикации

Electro-discharge system for neutralizing landmines

Номер: CA2921675A1
Принадлежит: VLN Advanced Technologies Inc

A landmine-neutralization system has a vehicle including a water supply tank and an electrical power supply and an electro-discharge apparatus. The electro-discharge apparatus includes one or more electro-discharge nozzles each having a discharge chamber that has an inlet for receiving water from the water supply tank and an outlet, a first electrode extending into the discharge chamber and being electrically connected to one or more high-voltage capacitors that are connected to, and chargeable by, the electrical power supply, a second electrode proximate to the first electrode to define a gap between the first and second electrodes and a switch to cause the one or more capacitors to discharge across the gap between the electrodes to create a plasma bubble which expands to form a shockwave that escapes through one or more exit orifices of the one or more nozzles ahead of the plasma bubble to thereby neutralize a landmine.

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01-03-2004 дата публикации

RF front-end of dual-mode wireless transceiver

Номер: TW200403930A
Принадлежит: Hon Hai Prec Ind Co Ltd

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13-11-2003 дата публикации

Predicting metabolic stability of drug molecules

Номер: WO2002075609A3

Methods are disclosed for developing models used to rapidly predict metabolic stability and regioselectivity of drug molecules. Training sets, based on a sample of molecules with known reaction rates and/or activation energies, are used along with structural descriptors of the molecules in order to develop mathematical models of metabolism based on regression analysis of the activation energies and descriptors. The resulting models are then used to predict the metabolism of other molecules. The invention is particularly useful in developing simple models of cytochrome p450 enzyme metabolism.

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14-01-2004 дата публикации

Predicting metabolic stability of drug molecules

Номер: EP1379997A2
Принадлежит: Arqule Inc

Methods are disclosed for developing models used to rapidly predict metabolic stability and regioselectivity of drug molecules. Training sets, based on a sample of molecules with known reaction rates and/or activation energies, are used along with structural descriptors of the molecules in order to develop mathematical models of metabolism based on regression analysis of the activation energies and descriptors. The resulting models are then used to predict the metabolism of other molecules. The invention is particularly useful in developing simple models of cytochrome p450 enzyme metabolism.

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26-09-2002 дата публикации

Predicting metabolic stability of drug molecules

Номер: WO2002075609A2
Принадлежит: ArQule, Inc.

Methods are disclosed for developing models used to rapidly predict metabolic stability and regioselectivity of drug molecules. Training sets, based on a sample of molecules with known reaction rates and/or activation energies, are used along with structural descriptors of the molecules in order to develop mathematical models of metabolism based on regression analysis of the activation energies and descriptors. The resulting models are then used to predict the metabolism of other molecules. The invention is particularly useful in developing simple models of cytochrome p450 enzyme metabolism.

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06-05-2004 дата публикации

Predicting metabolic stability of drug molecules

Номер: WO2002075609A9

Methods are disclosed for developing models used to rapidly predict metabolic stability and regioselectivity of drug molecules. Training sets, based on a sample of molecules with known reaction rates and/or activation energies, are used along with structural descriptors of the molecules in order to develop mathematical models of metabolism based on regression analysis of the activation energies and descriptors. The resulting models are then used to predict the metabolism of other molecules. The invention is particularly useful in developing simple models of cytochrome p450 enzyme metabolism.

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03-10-2002 дата публикации

Predicting metabolic stability of drug molecules

Номер: AU2002252221A1
Принадлежит: Arqule Inc

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21-11-2017 дата публикации

Integrated fluidjet system for stripping, prepping and coating a part

Номер: US09821337B2
Принадлежит: VLN Advanced Technologies Inc

An integrated liquidjet system capable of stripping, prepping and coating a part includes a cell defining an enclosure, a jig for holding the part inside the cell, an ultrasonic nozzle having an ultrasonic transducer for generating a pulsed liquidjet, a coating particle source for supplying coating particles to the nozzle, a pressurized liquid source for supplying the nozzle with a pressurized liquid to enable the nozzle to generate the pulsed liquidjet to sequentially strip, prep and coat the part, a high-voltage electrode and a ground electrode inside the nozzle for charging the coating particles, and a human-machine interface external to the cell for receiving user commands and for controlling the pulsed liquidjet exiting from the nozzle in response to the user commands.

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12-09-2017 дата публикации

Method and apparatus for prepping bores and curved inner surfaces with a rotating high-frequencey forced pulsed waterjet

Номер: US09757756B2
Принадлежит: VLN Advanced Technologies Inc

A method of prepping a cylindrical inner surface of a bore using a high-frequency forced pulsed waterjet apparatus entails generating a pressurized waterjet using a high-pressure water pump, generating a high-frequency signal using a high-frequency signal generator, applying the high-frequency signal to a transducer having a microtip to cause the microtip to vibrate to thereby generate the high-frequency forced pulsed waterjet, and rotating the rotatable ultrasonic nozzle inside the bore to prep the inner cylindrical surface of the bore using the high-frequency forced pulsed waterjets exiting from the angled exit orifices of the rotatable ultrasonic nozzle.

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01-08-2017 дата публикации

Integrated fluidjet system for stripping, prepping and coating a part

Номер: US09718091B2
Принадлежит: VLN Advanced Technologies Inc

A method of stripping, prepping and coating a surface comprises first stripping the exiting coating from a surface, using continuous or pulsed fluid jet, followed by prepping the surface by the same fluid jet. The method also provides entraining particles into a fluid stream, if desired to generate a particle-entrained fluid stream that is directed at the surface to be stripped and prepped. The particles act as abrasive particles for prepping the surface to a prescribed surface roughness required for subsequent application of a coating to the surface. The method then entails coating the surface by electrically charging particles having the same chemical composition as the particles used to prep the surface. Finally, a charged-particle-entrained fluid stream is directed at high speed at the charged surface to coat the surface. The particles form both mechanical and electronic bonds with the surface.

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06-12-2016 дата публикации

Integrated fluidjet system for stripping, prepping and coating a part

Номер: US09512531B2
Принадлежит: VLN Advanced Technologies Inc

A method of stripping, prepping and coating a surface includes first stripping the exiting coating from a surface, using continuous or pulsed fluid jet, followed by prepping the surface by the same fluid jet. The method also provides entraining particles into a fluid stream, if desired to generate a particle-entrained fluid stream that is directed at the surface to be stripped and prepped. The particles act as abrasive particles for prepping the surface to a prescribed surface roughness required for subsequent application of a coating to the surface. The method then entails coating the surface by electrically charging particles having the same chemical composition as the particles used to prep the surface. Finally, a charged-particle-entrained fluid stream is directed at high speed at the charged surface to coat the surface. The particles form both mechanical and electronic bonds with the surface.

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