28-01-2021 дата публикации
Номер: US20210023002A1
The invention relates to stable vancomycin hydrochloride powder for oral liquid formulations. Also provided herein are methods of using vancomycin oral liquid formulations for the treatment of certain diseases such as pseudomembranous colitis and as well as kits and related products thereof. 129-. (canceled)30. A non-sterile stable liquid formulation formulated for oral administration , consisting of:(a) buffering agent,(b) water,(c) a sweetener,(d) preservative,(e) vancomycin hydrochloride, and(f) at least one excipient selected from the group consisting of buffering agents, preservatives, sweeteners, flavoring agents, coloring agents, tonicity agents, chelating agents, ethyl alcohol, glycerin, syrup and oils,wherein the non-sterile stable liquid formulation is homogenous and stable for at least 1 week at ambient and refrigerated temperature and has a pH of 2.5-4.5.31. The liquid formulation of claim 30 , wherein the buffering agent is 0.1-0.4% w/v citric acid.32. The liquid formulation of claim 30 , wherein the preservative is selected from the group consisting of ascorbic acid claim 30 , ascorbyl palmitate claim 30 , benzyl alcohol claim 30 , BHA claim 30 , BHT claim 30 , erythorbic acid claim 30 , fumaric acid claim 30 , malic acid claim 30 , propyl gallate claim 30 , sodium ascorbate claim 30 , sodium benzoate claim 30 , sodium bisulfate claim 30 , sodium metabisulfite claim 30 , sodium sulfite claim 30 , parabens claim 30 , benzoic acid claim 30 , potassium sorbate claim 30 , and vanillin.33. The liquid formulation of claim 30 , wherein the buffering agents is selected from the group consisting of citric acid claim 30 , sodium citrate claim 30 , sodium tartarate claim 30 , sodium acetate claim 30 , sodium carbonate claim 30 , sodium polyphosphate claim 30 , potassium polyphosphate claim 30 , sodium pyrophosphate claim 30 , potassium pyrophosphate claim 30 , disodium hydrogenphosphate claim 30 , trisodium phosphate claim 30 , tripotassium phosphate claim 30 , ...
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