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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 8445. Отображено 100.
19-01-2012 дата публикации

Sustained release of nutrients in vivo

Номер: US20120015039A1
Принадлежит: NEW WORLD PHARMACEUTICALS LLC

Nutritional compositions delivered in vivo in a time controlled manner sustainable over long periods of time, provide enhancing athletic performance, increased hand/eye coordination and concentration on the task at hand.

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08-03-2012 дата публикации

Microencapsulation of bioactive substances and methods of making the same

Номер: US20120058195A1
Автор: Moti Harel
Принадлежит: Advanced Bionutrtion Corp

The present invention relates to microparticles and methods of making such microparticles that protect a bioactive substance from heat, humidity and oxidation. A microparticle comprising a bioactive substance, an agglomerating agent, an emulsifier and solid fats is disclosed. A method to produce a microparticle comprising an agglomerated bioactive substance enrobed in a double layer of solid fats and emulsifier is also disclosed.

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24-05-2012 дата публикации

Process for producing protein microparticles

Номер: US20120128779A1
Принадлежит: UNIVERSITY OF PRETORIA

The present invention relates to a process for producing protein microparticles in dilute organic acid solutions and in the absence of an alcohol such as ethanol. The microparticles are formed by dissolving a cereal prolamin protein in a concentrated organic acid solution with agitation and then diluting the solution with an aqueous solution. Protein microparticles having vacuoles are thus formed. The protein microparticles may be used to form powders, films, coatings, matrices, scaffolds and the like. Complete films can be formed from the protein microparticles of the invention.

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24-05-2012 дата публикации

Method for encapsulation of an edible oil, compositions comprising edible oil and the use thereof

Номер: US20120128831A1
Принадлежит: Individual

The present invention relates to a method for encapsulation of an edible oil using whey protein and a reducing sugar. The edible oil comprises long chain polyunsaturated fatty acids. Also compositions comprising an edible oil obtainable by the method of the invention are provided. The compositions of the invention have good stability to oxidation, good taste and/or odour, and limited diffusion from and into the continuous phase when applied in liquids. The compositions of the invention are particularly suitable for food and pharma applications.

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05-07-2012 дата публикации

Encapsulation of reactive components for 1-k systems using coaxial dies

Номер: US20120171492A1
Принадлежит: Evonik Roehm GmbH

The invention relates to the production of core-shell particles for encapsulating reactive components for single-component resin systems. In particular, the invention relates to the encapsulation of radical initiators such as peroxides. The invention further relates to a method for the 100% encapsulation of reactive components, whereby novel, storage-stable resin systems can be provided. At the same time, the core-shell particles are designed such that they can be opened nearly completely, easily and quickly during application, but have sufficient storage and shear stability before application.

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09-08-2012 дата публикации

Production of encapsulated nanoparticles at commercial scale

Номер: US20120202694A1
Принадлежит: Iceutica Pty Ltd

The present invention relates to methods for producing particles of a biologically active material using dry milling processes as well as compositions comprising such materials, medicaments produced using said biologically active materials in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active materials administered by way of said medicaments.

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27-09-2012 дата публикации

Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions

Номер: US20120244124A1
Принадлежит: Cobb and Assoc

A method of combating rheumatoid arthritis, comprising administering to a human subject in need thereof, an effective oral dose of a probiotic composition in an oral dose form including, as the only bacterial species therein, the bacterial species of Bacillus subtilis, Bacillus coagulans , and Enterococcus faecium . The initial occurrence, and progress of remission of the rheumatoid arthritis condition incident to such probiotic therapy, may be established and monitored by assay of rheumatoid factor and/or anti-CCP antibodies present in a blood sample of the human subject.

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04-10-2012 дата публикации

Probiotic Compositions, Methods and Apparatus for Their Administration

Номер: US20120247993A1
Принадлежит: Unistraw Patent Holdings Ltd

A probiotic composition including a probiotic microorganism embedded within a matrix, the matrix substantially maintaining the viability of said microorganisms. The matrix releases said microorganisms into and upon contact with a liquid carrier. The invention includes methods for manufacturing the composition, particular forms of the composition ( 2 ) and as apparatus for administration.

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06-12-2012 дата публикации

Compositions Comprising Dietary Fat Complexer and Methods for Their Use

Номер: US20120309712A1
Принадлежит: Artjen Complexus Inc

This invention relates to fat containing consumable food products comprising α-cyclodextrin. The food products have reduced levels of bioavailable fat but have substantially the same fat, cholesterol and caloric content as a like food without α-cyclodextrin. The invention also relates to methods for reducing the bioavailability of fats in fat containing food products without reducing caloric intake as determined by bomb calorimetry and to methods for increasing high density lipoproteins in a subject and reducing or controlling weight by administering the food products of this invention.

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13-12-2012 дата публикации

Liquid-filled chitosan-anionic liposoluble surfactant capsule dispersions

Номер: US20120315313A1
Принадлежит: Nestec SA

The present invention generally relates to the field of membranes. In particular, the present invention relates to a composition comprising bodies surrounded by a membrane. The composition are for example edible compositions. One embodiment of the present invention relates to a composition containing an oily fraction, a hydrophilic fraction, and at least one body, wherein the body comprises a shell comprising several molecular layers of chitosan and at least one lipidic phosphatidic acid surfactant; and a content comprising an internal phase containing a hydrophilic component and/or a hydrophobic component. The Composition may be used to protect a food product or to deliver specific properties to a product, for example.

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13-12-2012 дата публикации

Multiparticulate l-carnitine compositions and related methods

Номер: US20120315326A1
Автор: Noreen HASSAN, Syed Shah
Принадлежит: Hassan Noreen, Shah Syed

Enteric coated multiparticulate compositions that use a L-carnitine compound an active ingredient are disclosed. The multiparticulates have spheroidal core comprising a L-carnitine, microcrystalline cellulose, and hydroxypropyl methylcellulose; a sub-coat comprising hydroxypropyl methyl cellulose on the spheroidal core; and an enteric coat on the sub-coated spheroidal core. The average diameter of the particulates is about 0.1-3 mm. Other aspects of the invention include methods of making and methods of using the multiparticulate compositions.

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27-12-2012 дата публикации

Large glassy beads

Номер: US20120328732A1
Принадлежит: FIRMENICH SA

The present invention relates to a particulate composition in the form of a large spherical glassy bead having a cross-sectional diameter greater than 5 mm. The bead comprises an encapsulating carrier composition essentially made of fibrous materials, which are both sugarless and non-cariogenic and an encapsulant, such as a flavor material.

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17-01-2013 дата публикации

Multicarotenoid beadlets and related method

Номер: US20130017292A1
Принадлежит: ACCESS BUSINESS GROUP INTERNATIONAL LLC

A controlled release beadlet that sequentially releases carotenoids over time within the gastrointestinal tract of a subject, as well as a method of administering the carotenoids. The beadlet provides a specific ratio of carotenoids which release from the beadlet at preselected times during passage through the gastrointestinal tract. The method includes releasing the carotenoids in preselected ratios at specific time intervals in the gastrointestinal tract to mitigate competition between the carotenoids for their uptake, and/or to potentially maximize the uptake of individual carotenoids within a mixed carotenoid formulation.

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21-02-2013 дата публикации

Enclosing materials in natural transport systems

Номер: US20130045246A1
Принадлежит: Individual

Edible or potable substances can be transported in biodegradable vessel.

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21-03-2013 дата публикации

Coating fat composition and particulate composition using the same

Номер: US20130071525A1
Принадлежит: Kaneka Corp

A particulate composition, wherein a hydrophilic substance is polydispersed in a matrix of a fat composition having a solid fat content at 25 C of 58% or more and a solid fat content at 37 C of 90% or less; and a coating fat composition containing 45% by weight or more of a triglyceride comprising at least both a saturated fatty acid having 6 to 12 carbon atoms and a saturated fatty acid having 14 or more carbon atoms as constituent fatty acids, wherein the proportion of the saturated fatty acid having 14 or more carbon atoms in the constituent fatty acids of the whole fat exceeds 50% by weight.

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18-04-2013 дата публикации

Infant nutrition for improving fatty acid composition of brain membranes

Номер: US20130096087A1
Принадлежит: Nutricia NV

The present invention relates to infant nutrition, in particular to infant nutrition comprising special lipid globules for improvement of the fatty acid composition in brain membranes.

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09-05-2013 дата публикации

Method of making nutritional emulsions containing process- encapsulated oils

Номер: US20130115355A1
Принадлежит: ABBOTT LABORATORIES

Disclosed is a method of making nutritional emulsions, comprising: (A) heating and blending together an emulsifying agent having a melt point above about 25 C and oil having hydrophobic off-notes (e.g. non-encapsulated polyunsaturated fatty acid) in a weight ratio of at least about 1:15; (B) adding the heated blend to a fat, protein, and carbohydrate mixture comprising a maltodextrin (DE of about 10 or less), in a weight ratio of the maltodextrin to the oil having hydrophobic off-notes of at least about 1:2; and (C) homogenizing, and then cooling the combination below the melt point of the emulsifying agent to form a nutritional emulsion comprising from about 0.01% to about 5% by weight of process-encapsulated polyunsaturated fatty acid. The resulting nutritional emulsions effectively mask off-notes commonly associated with certain oils, e.g., polyunsaturated fatty acids, soy oil, beta-hydroxy-beta-methylbutyrate oils.

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23-05-2013 дата публикации

Nutritional compositions comprising fruit flakes containing docosahexaenoic acid

Номер: US20130129860A1
Автор: Gabriela Chavez
Принадлежит: Nestec SA

Nutritional compositions and methods for making and using said nutritional compositions are provided. In a general embodiment, the present disclosure provides a nutritional composition that has fruit flakes that include docosahexaenoic acid. The docosahexaenoic acid can be incorporated directly in the fruit flakes.

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06-06-2013 дата публикации

Beverage cartridge

Номер: US20130142915A1
Принадлежит: Individual

The present invention relates to a beverage cartridge for use in a beverage preparation machine, the cartridge being formed from substantially water-impermeable materials and comprising an inlet for the introduction of an aqueous medium into the cartridge and an outlet for discharge of a beverage produced from the aqueous medium and one or more beverage ingredients contained in the cartridge, wherein the one or more beverage ingredients includes one or more discrete edible components which are substantially insoluble in the aqueous medium and which, in use, are dispensed from the cartridge with the beverage.

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13-06-2013 дата публикации

Process for producing protein microparticles

Номер: US20130150461A1
Принадлежит: UNIVERSITY OF PRETORIA

The present invention relates to a process for producing protein microparticles in dilute organic acid solutions and in the absence of an alcohol such as ethanol. The microparticles are formed by dissolving a cereal prolamin protein in a concentrated organic acid solution with agitation and then diluting the solution with an aqueous solution. Protein microparticles having vacuoles are thus formed. The protein microparticles may be used to form powders, films, coatings, matrices, scaffolds and the like. Complete films can be formed from the protein microparticles of the invention.

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17-10-2013 дата публикации

Protein-polysaccharide macromolecular complex article of manufacture containing encapsulated ethyl alcohol

Номер: US20130273211A1
Принадлежит: Individual

An protein-polysaccharide macromolecular complex article of manufacture containing encapsulated ethyl alcohol and/or other spirits serving as an entertaining and novel non-beverage method of consuming alcohol. The article of manufacture encapsulates ethyl alcohol and/or other spirits in the amorphous regions of the complex macromolecular structure releasing it only upon chewing and exposure to the environment of the oral cavity. The article of manufacture is stable and capable of retaining shape and form for extended periods of time at ambient temperature allowing for relatively low-cost commercial manufacture and distribution.

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06-02-2014 дата публикации

Microcapsules containing an oxidizable active, and a process for preparing the same

Номер: US20140037744A1
Принадлежит: Idcaps SAS

Disclosed is a microcapsule including a core having an oxidizable active (OA), the outer part of said core being in a solid form, and a water insoluble coating obtained from an encapsulating agent (EA), with the coating surrounding said core. In particular, there is disclosed a microcapsule wherein the EA is water soluble or organic solvent, in particular ethanol, soluble, or a microcapsule wherein said EA is an agent, the water solubility of which is pH-dependent. In particular, the core does not consist in or comprise a metal oxide, and the coating does not comprise a disintegrant, in particular sodium starch glycolate. Also disclosed is a process for preparing the microcapsules.

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06-01-2022 дата публикации

FLAVONOID DELIVERY SYSTEM

Номер: US20220000160A1
Принадлежит:

The invention relates to a flavonoid delivery system comprising a co-precipitate of a hydrophobic flavonoid and a protein. The flavonoid delivery system comprises a high ratio of flavonoid to protein, allowing food products to be fortified with relatively large amounts of flavonoid without compromising the sensory properties of the food product. 1. A flavonoid delivery system comprising a co-precipitate of a hydrophobic flavonoid and a protein.2. The flavonoid delivery system of wherein the co-precipitate comprisesthe hydrophobic flavonoid entrapped in a protein matrix.3. The flavonoid delivery system of wherein the co-precipitate comprisesnanocrystals of the hydrophobic flavonoid entrapped in the protein matrix.4. The flavonoid delivery system of wherein the co-precipitate has been dispersed in a phosphate solution and spray dried.5. The flavonoid delivery system of claim 1 , wherein the hydrophobic flavonoid and the protein are selected such that they both precipitate from aqueous solution at an isoelectric point of the protein.6. The flavonoid delivery system of wherein the hydrophobic flavonoid has a hydrophobicity of about 2 to about 4 and/or is soluble in aqueous solution at high pH claim 1 , preferably above 10.7. The flavonoid delivery system of wherein the hydrophobic flavonoid is selected from rutin claim 1 , naringenin claim 1 , quercetin claim 1 , curcumin claim 1 , hesperidin claim 1 , alpha-naphthoflavone (ANF) claim 1 , beta-naphthoflavone (BNF) claim 1 , catechin and catechin derivatives claim 1 , chrysin claim 1 , luteolin claim 1 , myricetin and anthocyanins.8. The flavonoid delivery system of wherein the protein has an isoelectric point of about 4 to about 6.5.9. The flavonoid delivery system of wherein the protein is selected from sodium caseinate claim 1 , soy protein isolate claim 1 , pea protein isolate claim 1 , denatured whey protein isolate and milk protein isolate.10. The flavonoid delivery system of wherein a mass ratio of protein: ...

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02-01-2020 дата публикации

BAKED GOODS

Номер: US20200000106A1
Принадлежит:

The present invention describes compositions and methods comprising lactic acid-producing bacteria in baked goods. 1. A composition comprising a baked composition of an edible starch and an isolated Bacillus coagulans bacterium.2. The composition of claim 1 , wherein said baked composition is selected from the group consisting of a bread claim 1 , a cake claim 1 , a pie claim 1 , a tart claim 1 , a pastry claim 1 , a candy bar claim 1 , an energy bar claim 1 , a granola bar claim 1 , a quiche claim 1 , a cookie claim 1 , and a treat for companion animals.3. The composition of claim 2 , wherein said cake is a muffin.4. The composition of claim 3 , wherein said muffin is a blueberry bran muffin.5Bacillus coagulans. The composition of claim 1 , wherein said isolated comprise between 0.01% and 10% by weight of said baked good.6Bacillus coagulansBacillus coagulans. The composition of claim 1 , wherein said isolated is hammer strain Accession No. ATCC 31284.7Bacillus coagulans. The composition of claim 1 , wherein said isolated is GBI-30 strain (ATCC Designation Number PTA-6086).8Bacillus coagulans. The composition of claim 1 , wherein said isolated is GBI-20 strain (ATCC Designation Number PTA-6085).9Bacillus coagulans. The composition of claim 1 , wherein said isolated is GBI-40 strain (ATCC Designation Number PTA-6087).10Bacillus coagulans. The composition of claim 1 , wherein said isolated is in the form of a spore.11Bacillus coagulans. The composition of claim 1 , wherein said isolated is in the form of a vegetative cell.12Bacillus coagulans. The composition of claim 1 , wherein said isolated is in the form of a mixture of vegetative cells and spores.13. A method of making a baked good comprising:providing a flour containing base mix and a liquid portion of water; mixing said flour containing base mix and said water to form a batter or dough;{'i': 'Bacillus coagulans', 'applying an isolated bacterium to said batter or dough; and'}heat processing said batter or dough ...

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07-01-2016 дата публикации

Composition, batter material using same, food or drink and feed, and method of producing composition

Номер: US20160000122A1
Принадлежит: J Oil Mills Inc

A composition containing a starch at a content of equal to or higher than 75% by mass, wherein the composition contains a low molecular weight starch as the starch at a content of equal to or higher than 3% by mass and equal to or lower than 45% by mass, the low molecular weight starch being obtainable from a starch containing amylose at a content of equal to or higher than 5% by mass as a raw material, wherein a peak molecular weight of the low molecular weight starch is equal to or higher than 3×10 3 and equal to or lower than 5×10 4 , wherein a degree of swelling in cold water of the composition at 25 degrees C. is equal to or higher than 7 and equal to or lower than 20, and wherein a content of an oversieve fraction of a granulated material in the composition on 0.5 mm mesh is equal to or lower than 50% by mass.

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02-01-2020 дата публикации

Nutritional composition in powder form provided in single serving capsules

Номер: US20200000137A1
Принадлежит: Societe Des Produits Nestles S.A.

The present invention relates to a nutritional formula in powder form provided in single dose capsules, wherein the powder particles are at least partially coated with phospholipids. The nutritional formula has improved in-capsule dissolution properties compared to known nutritional formulae. The present invention also relates to a process for the production of such nutritional formula and to the use of phospholipids to improve the in-capsule dissolution of a nutritional formula.

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05-01-2017 дата публикации

Barrier layer capsules

Номер: US20170000176A1
Принадлежит: Givaudan SA

An active-containing microparticle adapted to release the active in a desired end-use, comprising (a) an active-containing core active-containing core, optionally formed on an inner core, comprising a continuous hydrophilic medium in which at least one active is dissolved or is present as? dispersed particles; (b) an active-free barrier layer, surrounding completely the core; and (c) surrounding the barrier layer, a layer of polymeric material having a solubility in water at 25° C. of 0.1% by weight maximum; the barrier layer comprising a material selected from waxes, fats and materials suitable for use as the continuous hydrophilic medium of the core, and which is solid in the conditions of the desired end-use. The particles are useful, for example, for the delayed release of flavors in foods and beverages.

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04-01-2018 дата публикации

Liquid Embedded Nutritional Bar

Номер: US20180000144A1
Автор: Hawkins Alfonzo
Принадлежит:

Provided is a nutritional bar which includes a body portion having a protein or energy-filled food, and at least one embedded portion which is embedded within the body portion that includes liquid and/or gel for consumption. The nutritional bars can be snack bars, energy bars or dietary bars, for example, and enable a consumer to have an additional source for water consumption as recommended. 1. A nutritional bar comprising:a body portion comprising a protein or energy-filled food; andat least one embedded portion which is embedded within the body portion and comprising liquid and/or gel for consumption, and a housing or film for housing the liquid therein.2. The nutritional bar of claim 1 , wherein the liquid and/or gel is encapsulated by the housing or film.3. The nutritional bar of claim 2 , wherein the protein or energy-filled food may include cereal claim 2 , grain claim 2 , oats claim 2 , fruit claim 2 , candy claim 2 , chocolate or any other protein or energy-filled food.4100. The nutritional bar of claim 2 , wherein the nutritional bar is held together by saturated gums claim 2 , proteins or fibers.5. The nutritional bar of claim 2 , wherein the liquid and/or gel includes water claim 2 , juice claim 2 , electrolytes or any other type of consumable liquid or gel.6. The nutritional bar of claim 2 , wherein the housing or film comprises a protective covering to prevent the liquid and/or gel therein from penetration during a baking process thereof.7. The nutritional bar of claim 1 , wherein the at least one embedded is a liquid-filled ball or a gel-filled ball which burst when bitten into by the consumer.8. The nutritional bar of claim 1 , wherein the housing or film is formed of a translucent and/or chewy material.9. A nutritional bar comprising:a body portion including a protein or energy-filled food; anda plurality of embedded portions filled with a liquid and/or gel, and a housing or film for housing the liquid therein.10. The nutritional bar of claim 9 , ...

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04-01-2018 дата публикации

Modified Alginate Hydrogels for Therapeutic Agents, their Preparation and Methods Thereof

Номер: US20180000743A1
Принадлежит:

A novel chemically modified alginate hydrogel has been developed which combines an aromatic compound with a carbohydrate, where the aromatic compound is one or more amines combined with an alginate. The chemical structure of alginate is modified using different amines and different methods, including: (1) covalently bonding aminoethyl benzoic acid to the alginate backbone, and (2) oxidizing the vicinal diol in the alginate chain to an aldehyde before coupling to aminoethyl benzoic acid. Alternatively, the combined aromatic compound and carbohydrate can be a dopamine combined with the alginate. The chemically modified alginate and the methods used can be utilized to encapsulate a variety of bioactive substances for oral delivery in humans and animals, including, but not limited to: (i) drugs, medicines, enzymes, proteins, hormones, and vaccines, (ii) vitamins, minerals, micronutrients and/or other dietary supplements, (iii) probiotics and/or other microorganisms, (iv) cells, cell parts, and/or other biological materials, and/or (v) other bioactive substances. 1. A composition comprising a substance wherein said substance comprises one or more (i) drugs , medicines , enzymes , proteins , hormones , vaccines , vitamins , minerals , micronutrients and/or other dietary supplements , (ii) probiotics and/or other microorganisms , (ii) cells , cell parts , and/or other biological materials , and/or (iii) other bioactive compounds or substances ,in combination with a modified alginate, wherein said modified alginate comprises an alginate backbone that has been modified by the addition of an aromatic compound substituent.2. The composition of wherein the aromatic substituent comprises one or more of a dopaminic substituent claim 1 , a phenolic substituent claim 1 , a benzoic acid substituent claim 1 , an anilinic substituent claim 1 , a toluenic substituent claim 1 , an amino sulfonamidic benzene substituent and/or mixtures thereof.3. The composition of claim 2 , wherein the ...

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05-01-2017 дата публикации

MICROCAPSULES WITH POLYMERIC COATING COMPRISING A LIPID AND AN ACTIVE AGENT

Номер: US20170000741A1
Принадлежит:

The present invention relates to microcapsules and to methods for preparing them. The microcapsules comprise a polymeric coating that is at least partly crosslinked with a polymeric matrix comprising a polysaccharide. In the matrix, a lipid and an active agent or a prodrug or salt thereof are embedded, the lipid preferably having a melting point of at least 30° C. The microcapsules can be used as a medicament, dietary supplement or food additive, the microcapsules comprising a polymeric coating that is at least partly crosslinked with a polymeric matrix comprising a polysaccharide. As above, a lipid and an active agent or a prodrug or salt thereof are embedded in the matrix, with the lipid preferably having a melting point of at least 30° C. Methods for treating diarrhea or preventing colon cancer comprising administering such microcapsules are also disclosed. 1. Microcapsules comprising a polymeric coating , the polymeric coating being at least partly crosslinked with a polymeric matrix comprising a polysaccharide , wherein in the matrix a lipid and an active agent or a prodrug or salt thereof are embedded , the lipid preferably having a melting point of at least 30° C.2. The microcapsules according to claim 1 , wherein the polysaccharide is selected from the group consisting of pectins claim 1 , alginates claim 1 , carrageenans claim 1 , xanthan claim 1 , gellan claim 1 , tragacanth claim 1 , hyaluronic acid claim 1 , gums claim 1 , celluloses claim 1 , starches claim 1 , agar claim 1 , arabinoxylans claim 1 , curdlan claim 1 , beta-glucan claim 1 , glucomannans claim 1 , pullulan claim 1 , chondroitin sulfate claim 1 , dextrans claim 1 , chitosans claim 1 ,aminodextran and dimethylaminodextran and derivatives of the aforementioned polysaccharides.3. The microcapsules according to claim 1 , wherein the embedded lipid has a melting point of from 30° C. to 80° C. claim 1 , and wherein the lipid preferably crystallizes upon cooling in the beta prime crystal form.4. ...

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03-01-2019 дата публикации

Method for Producing Colloidosome Microcapsules

Номер: US20190001294A1
Принадлежит:

This invention relates to a process for colloidosome-type microcapsules elaboration from solid particles microcapsules obtained by ionic gelation. In the process, an (O/W) type emulsion is initially generated stabilized with the solid particles microcapsules, and then the particles are fixed to the interface by adsorption of polyelectrolytes, cross-linking, heat treatment or fatty coating, generating the colloidosome with the water-insoluble phase encapsulated in the core and covered by the shell particles. 1) A process for elaborating colloidosomes-type microcapsules comprising:a) dispersing in water agglomerates of solid particles microcapsules obtained by ionic gelation to form a suspension;b) emulsify a liquid insoluble in water using as emulsifier the suspension obtained in a); andc) fix the solids adsorbed on the water-liquid interface insoluble in water, to obtain the colloidosomes.2) A process according to claim 1 , wherein the mixture obtained in c) is dried to obtain powder colloidosomes.3) A process according to claim 1 , wherein the microcapsules of step a) comprise water-insoluble solids selected from the group consisting of metallic and non-metallic minerals claim 1 , phyllosilicates claim 1 , polymer particles and insoluble solids obtained via synthesis claim 1 , extraction or by bioprocesses.4) A process according to claim 1 , wherein the solid particles microcapsules of step a) have a size between 10 nm and 1000 μm.5) A process according to claim 1 , wherein in step a) shear-type disruptive forces claim 1 , cavitation claim 1 , shock claim 1 , pressure drop or combinations thereof are applied to prevent the agglomerates formation.6) A process according to claim 1 , wherein the fixation of the adsorbed particles on the water-liquid interface water-insoluble of step c) is carried out by polyelectrolytes adsorption claim 1 , cross-linking claim 1 , heat treatment and/or treatment with a fatty acid emulsion or fatty acids mixture.7) A process according ...

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02-01-2020 дата публикации

PLATED YEAST FORMULATIONS

Номер: US20200002666A1
Принадлежит: FIRMENICH SA

Provided herein is a composition comprising: a) about 25% up to about 75% of a plasmolysed micro-organism by weight of the total weight of the composition; b) about at least greater than 20% up to about 60% by weight flavor or fragrance, of the total weight of the composition c) about 1% up to about 25% desiccant; d) about 4% up to about <10% water; wherein the mean particle size distribution by weight of the composition is about greater than 100 micrometer up to about 1 millimeter. Also provided herein is a method of making a plated yeast composition comprising a. blending: i) a homogenous cake, wherein the cake is made by mixing, at a temperature that ranges from 20° C. to about 90° C. a) a plasmolysed micro-organism in an amount of from about 0.01% to about 90% by weight of the total weight of the cake; b) a flavor or fragrance oil provided in an amount of from at least 0.01% up to about 60% by weight of the total weight of the cake; and c) water provided in an amount of from about 5% up to about 90% by weight of the total weight of the cake; wherein the micro-organism to water ratio in the cake is provided in an amount, by weight, of about 4.5:1 to 0.5:1; with ii) at least about 40% up to about 99.9%, by weight desiccant, of the total weight of the composition; iii) optionally from about 0.2 to about 2% by weight a flow agent of the total weight of the composition to form a uniform mixer. b. sifting the blended mixer to form a powder with a particle size about 100 to 1,000 micrometer. 1. A composition comprising:a) 25% up to 75% of a plasmolysed micro-organism by weight of the total weight of the composition;b) at least greater than 20% up to 60%, by weight flavor or fragrance, of the total weight of the composition,c) 1% up to 25% desiccant; andd) 4% up to about less than 10% water; wherein the mean particle size distribution by weight of the composition is greater than 100 micrometer up to 1 millimeter.2. The composition as recited in claim 1 , wherein the ...

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13-01-2022 дата публикации

ADMINISTRATION AND DOSAGE OF DIAMINOPHENOTHIAZINES

Номер: US20220008431A1
Принадлежит: WisTa Laboratories Ltd.

The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels. 2. (canceled)3. The method as claimed in claim 1 , wherein the total daily dosage is 2 to 15 mg; or 3 to 10 mg.411-. (canceled)1314-. (canceled)16. The method as claimed in claim 1 , wherein the or each protic acid is an inorganic acid.1718-. (canceled)19. The method as claimed in claim 1 , wherein the or each protic acid is an organic acid.20. The method as claimed in claim 19 , wherein the or each protic acid is selected from HCO; CHCOOH; methanesulfonic acid claim 19 , 1 claim 19 ,2-ethanedisulfonic acid claim 19 , ethansulfonic acid claim 19 , naphthalenedisulfonic acid claim 19 , and p-toluenesulfonic acid.22. The method as claimed in claim 21 , wherein the total daily dose of LMTM is around 0.8 to 33 mg/day claim 21 , more preferably 6 to 12 mg/day of LMTM total.23. The method as claimed in wherein the dose of LMTM is around 9 mg/once per day.2537-. (canceled)3940-. (canceled)41. The method as claimed in claim 1 , wherein the subject has not historically received treatment with an acetylcholinesterase inhibitor or an N-methyl-D-aspartate receptor antagonist.42. The method as claimed in claim 1 , wherein the subject has historically received treatment with an acetylcholinesterase inhibitor and\or an N-methyl-D-aspartate receptor antagonist claim 1 , but ceased that medication at least 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , 6 claim 1 , 7 claim 1 , or 8 weeks prior to treatment with the MT containing compound.43. The method as claimed in claim 1 , wherein the subject is selected as one who is receiving treatment with an acetylcholinesterase inhibitor and\or an N-methyl-D-aspartate receptor antagonist claim 1 ,wherein said ...

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12-01-2017 дата публикации

Methods of Incorporating Micropellets of Fine Particle Nutrients into Snack Food Products

Номер: US20170006910A1
Принадлежит:

Nutritious granular materials of fine particle sizes agglomerated within versatile micropellets are useful for inserting significant amounts of nutritious properties into snack foods. Expandable micropellet-containing formulations provide for introduction of fine particle ingredients such as proteins, minerals and other components or desirable nutrients into food processing lines not typically amenable to the fine particle sizes. Micropellet-containing formulations may consist entirely of micropellets, or may contain an expandable starch such as, for example, corn meal, sheeted doughs, and expanded collet products onto which the micropellets may be basted. 1. A method of manufacturing snack food products , said method comprising the steps of:a. providing an expandable micropellet-containing formulation, said formulation comprising a plurality of discrete micropellets having fine particle components agglomerated therein, said plurality of micropellets comprising a particle size distribution wherein at least 75% of the micropellets are larger than 50 mesh; andb. cooking said formulation to form a snack food product.2. The method of wherein said micropellet-containing formulation consists only of said plurality of micropellets.3. The method of wherein said micropellet-containing formulation further comprises an expandable starch-comprising component.4. The method of wherein said micropellets expand upon heating.5. The method of wherein said expandable starch-comprising component comprises unagglomerated particles derived from corn.6. The method of wherein said unagglomerated starch particles comprise a particle size distribution wherein between about 30% to about 65% of said particles fall between 500 to about 700 microns.7. The method of wherein said micropellet-containing formulation further comprises a sheetable dough claim 1 , said plurality of micropellets having been combined with said dough prior to said cooking step.8. The method of wherein said plurality of ...

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14-01-2021 дата публикации

LACTASE-CONTAINING DOUBLE MICROCAPSULE, PREPARATION METHOD THEREFOR, AND USE THEREOF

Номер: US20210007367A1
Автор: AHN Sung-Il, KWAK Hae-Soo
Принадлежит:

The present invention provides a lactase-containing double microcapsule which includes; lactase provided as a core material; and a primary coating material and a secondary coating material, which are sequentially coated on the core material to be formulated, a method for preparing the lactase-containing double microcapsule, and a dairy product including the lactase-containing double microcapsule as a use of the lactase-containing double microcapsule. 1. A lactase-containing double microcapsule comprising: lactase provided as a core material; and a primary coating material and a secondary coating material , which are sequentially coated on the core material to be formulated.2. The lactase-containing double microcapsule according to claim 1 , wherein the primary coating material includes at least one selected from the group consisting of medium-chain triglyceride (MCT) claim 1 , hydrogenated corn oil claim 1 , soybean oil claim 1 , safflower seed oil and butter oil.3. The lactase-containing double microcapsule according to claim 1 , wherein the secondary coating material includes at least one selected from the group consisting of hydroxypropyl methylcellulose phthalate claim 1 , zein claim 1 , shellac claim 1 , Eudragit claim 1 , cellulose acetate phthalate claim 1 , cellulose acetate succinate claim 1 , polyvinyl acetate phthalate claim 1 , cellulose acetate trimellitate claim 1 , hypromellose acetate succinate and phenyl salicylate.4. The lactase-containing double microcapsule according to claim 1 , wherein the formulation is in any form selected from the group consisting of powders claim 1 , solution claim 1 , tablets claim 1 , and granules.5. A method for preparing lactase-containing double microcapsule comprising:providing lactase as a core material, and stirring the core material with a primary coating material and a primary emulsifier to obtain an emulsion of lactase;stirring the emulsion of lactase with secondary coating material and a secondary emulsifier ...

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14-01-2021 дата публикации

HEAT TOLERANT FILLING BASE FOR HIGH TEMPERATURE, HIGH-PRESSURE COOKING CO-EXTRUSION

Номер: US20210007369A1
Принадлежит:

Soft and creamy lipid-based food fillings suitable for high-temperature, high-pressure cooking co-extrusion are provided. In one approach, the filling includes about 30 to about 45 weight percent of an edible lipid having a melting point of about 45° C. or lower, about 0.5 to about 5 weight percent of a high oil-binding capacity material having an oil-binding capacity of at least about 100%, about 10 to about 30 weight percent of amorphous materials, and less than 30 weight percent sugar, sugar alcohol, or combinations thereof. The fillings generally have a particle size distribution with D50 of about 25 microns or less. Preferably, the fillings have a low water activity of about 0.45 or less and are substantially free of polyhydric alcohols and polyhydric alcohol-based humectants. The fillings maintain their soft and creamy texture after high-temperature, high-pressure cooking co-extrusion, subsequent baking, and throughout storage. 1. A soft and creamy textured lipid-based food filling suitable for high-temperature , high-pressure cooking co-extrusion , the filling comprising:about 30 wt. % to about 45 wt. % of an edible lipid forming a continuous lipid phase;about 0.5 wt. % to about 5 wt. % of a high oil-binding capacity material, the high oil-binding capacity material having an oil-binding capacity of greater than 100%;about 10 wt. % to about 30 wt. % of an amorphous material;less than 30 wt. % sugar, sugar alcohol, or combinations thereof; anda water activity (Aw) of about 0.45 or lower,wherein the filling has a particle size distribution with D50 of about 25 microns or less.2. The filling of claim 1 , wherein the filling contains substantially no polyhydric alcohols.3. The filling of claim 1 , where in the filling has a stiffness of less than 4000 Pascal and firmness of less than 60 Newton after baking at 8 min at 149° C. based on the heat tolerance test.4. The filling of claim 1 , wherein the filling contains about 10 wt. % to about 25 wt. % of the amorphous ...

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10-01-2019 дата публикации

HIGH INTEGRITY ENCAPSULATION PRODUCT

Номер: US20190008202A1
Принадлежит: McCormick & Company, Incorporated

High Integrity Encapsulation Product with Insoluble Fibers. A particulate extrusion encapsulation product in a glassy state is described including an encapsulate, encapsulated in a glassy matrix. The glassy matrix includes at least one modified starch, at least one carbohydrate and at least one insoluble fiber. The load of the encapsulate is typically from 0.01% to 20% by weight, based on the total weight of the encapsulation product. A method of making the particulate extrusion encapsulation product and food products containing the extrusion encapsulation product are also described. 2. The product of claim 1 , wherein the insoluble fiber comprises about 3% to about 8% by weight.3. The product of claim 1 , wherein at least 80% of the particles in the particulate product are unbroken claim 1 , based on total number of particles in the particulate product.4. The product of claim 1 , wherein at least 85% of the particles in the particulate product are unbroken claim 1 , based on total number of particles in the particulate product.5. The product of claim 1 , wherein at least 90% of the particles in the particulate product are unbroken claim 1 , based on total number of particles in the particulate product.6. The product of wherein the average size of the fibers is about 20 to about 300 microns.7. The product of wherein the average size of the fibers is about 50 to about 200 microns.8. The product of wherein the average size of the fibers is about 75 to about 150 microns.9. The product of claim 1 , wherein the matrix contains about 49% to about 94% by weight of the modified starch and about 5% to about 50% of the low molecular weight carbohydrate.10. The product of claim 1 , wherein the low molecular weight carbohydrate has an average molecular weight less than about 800 g/mol.11. The product of claim 1 , wherein the low molecular weight carbohydrate comprises a sugar claim 1 , polyol claim 1 , corn syrup solid claim 1 , or mixtures thereof.12. The product of claim 1 , ...

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17-01-2019 дата публикации

Encapsulated Oil for Powdered Instant Food Products

Номер: US20190014810A1
Принадлежит: GENERAL MILLS, INC.

An encapsulated product including solid particles of a matrix in which discrete, film coated oil droplets are embedded is provided. The matrix includes a continuous phase in which a discrete phase of the matrix and the oil droplets are embedded. The encapsulated product disintegrates readily in water or an aqueous solution. 2. The encapsulated product of claim 1 , wherein the continuous phase further comprises a softener selected from glycerol claim 1 , inositol claim 1 , high fructose corn syrup claim 1 , honey claim 1 , and a combination thereof in an amount of about 1-7% by weight of the particle.3. The encapsulated product of claim 1 , wherein the continuous phase further comprises an antioxidant or component that improves the effect of an antioxidant selected from ascorbic acid claim 1 , sodium ascorbate claim 1 , citric acid claim 1 , sodium citrate claim 1 , potassium citrate claim 1 , calcium citrate claim 1 , erythorbic acid claim 1 , and combinations thereof.4. The encapsulated product of claim 1 , wherein the continuous phase comprises pre-gelatinized starch claim 1 , maltodextrin claim 1 , whey protein claim 1 , a caseinate claim 1 , or a combination thereof.5. The encapsulated product of claim 1 , wherein the film of the film coated droplets comprises whey protein claim 1 , a caseinate claim 1 , a plant protein claim 1 , a gum claim 1 , or a combination thereof.6. The encapsulated product of claim 1 , wherein the continuous phase comprises whey protein claim 1 , and the film of the film coated oil droplets contains substantially no caseinate.7. The encapsulated product of claim 1 , wherein the continuous phase comprises whey protein claim 1 , and includes inositol in an amount of about 1-7% by weight of the particle.8. The encapsulated product of claim 1 , wherein the continuous phase comprises a water soluble carbohydrate claim 1 , and includes glycerol in an amount of about 1-7% by weight of the particle claim 1 , and contains substantially no protein ...

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18-01-2018 дата публикации

ALL-NATURAL ENTERIC SOFT CAPSULES

Номер: US20180015059A1
Принадлежит:

Described herein are soft capsules and enteric soft capsules comprising cationic Type A gelatin and acid insoluble enteric polymers. In particular, the compositions and methods for manufacturing all-natural enteric soft capsules comprising Type A gelatin and matrix fills are described. In one embodiment, the enteric soft capsules comprise active ingredients such as non-steroidal anti-inflammatory drugs (NSAIDs). In another embodiment, the enteric soft capsule comprises matrix fills of omega-3 fatty acids. 1. An enteric soft capsule gel mass composition consisting of:(a) about 33% to about 36% Type A gelatin by mass;(b) about 3.3% pectin by mass;(c) about 16% glycerol by mass; andthe viscosity of the gel mass composition comprises about 20,000 cP to about 30,000 cP.2. The composition of claim 1 , wherein upon extrusion to a ribbon claim 1 , the ribbon comprises a strength of about 1.5 kg to about 2.5 kg.4. The composition of claim 1 , wherein the Type A gelatin has a Bloom strength of about 150 grams to about 350 grams.5. The capsule of claim 1 , wherein the Type A gelatin comprises acid bone gelatin or pig skin gelatin.6. The composition of claim 1 , wherein the Type A gelatin comprises acid bone gelatin.7. The composition of claim 1 , wherein the Type A gelatin comprises pig skin gelatin.8. The composition of claim 1 , wherein the ribbon comprises a thickness of about 0.03 inches to about 0.045 inches.9. A method for preparing the enteric soft capsule of claim 1 , the method comprising:combining the gelatin, pectin, glycerol and water with heating to form a gel mass; and(ii) forming an enteric soft capsule from the gel mass using rotary die technology further comprising a fill comprising one or more active ingredients.10. The enteric soft capsule formed by the method of .11. The capsule of claim 9 , wherein the capsule shell does not dissolve in simulated gastric fluid (pH 1.2) for at least 2 hours claim 9 , and begins dissolution in simulated intestinal fluid (pH ...

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16-01-2020 дата публикации

Agglomerated Ingredient Delivery Composition

Номер: US20200015488A1
Принадлежит:

Disclosed herein are compositions comprising agglomerates formed of fruit flakes and target ingredients, such as flavorings, colorings, aromatic particles, nutrients, etc. Also disclosed are methods for making fruit flake agglomerates that can deliver higher concentrations of flavorings, colorings, aromatic particles, nutrients, etc. 1. A method for making an ingredient delivery product , the method comprising co-agglomerating at least one target ingredient with at least one fruit flake to produce a fruit flake/target ingredient agglomerate formed of fruit flake agglomerates comprising the at least one target ingredient.2. The method of wherein the fruit flake/target ingredient agglomerateprovides the at least one target ingredient in a fruit flake carrier, which can release the at least one target ingredient upon contact with a sufficient amount of water to promote the dissolution of the fruit flake carrier.3. The method of wherein the target ingredient is selected from the group consisting of at least one flavor claim 1 , color claim 1 , vitamin claim 1 , mineral claim 1 , protein claim 1 , fat claim 1 , carbohydrate claim 1 , processing aid claim 1 , binder claim 1 , emulsification agent claim 1 , bioactive claim 1 , and combinations thereof.4. The method of wherein the fruit flake comprises at least one fruit selected from the group consisting of strawberries claim 1 , blueberries claim 1 , blackberries claim 1 , peaches claim 1 , plums claim 1 , apples claim 1 , and combinations thereof.5. The method of wherein the fruit flake comprises at least one vegetable selected from the group consisting of corn claim 1 , potatoes claim 1 , rice claim 1 , and combinations thereof.6. A method for agglomerating at least one fruit flake and at least one target ingredient claim 1 , the method comprising the steps ofa. admixing the at least one fruit flake and at least one dry-particle target ingredient to produce a fruit flake/target ingredient mixture;b. adding the fruit ...

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21-01-2021 дата публикации

PARTICLE CONTAINING AT LEAST ONE VOLATILE SUBSTANCE, PROCESS FOR ITS PREPARATION, A FOOD OR FEED ADDITIVE CONTAINING THE SAME AND USE

Номер: US20210015123A1
Принадлежит: Erber Aktiengellschaft

A particle containing at least one hydrophobic matrix material and at least one volatile substance, the particle contains 60% to 90% by weight of the at least one matrix material, whereby the at least one matrix material is selected from the group of fats, hydrogenated triglycerides and waxes that are solid or semi-solid at 20° C. and 1 atmosphere, that the particle contains 10% to 40% by weight of the at least one volatile substance, whereby the at least one volatile substance is selected from essential oils and/or plant extracts, that the at least one volatile substance is homogeneously distributed in the at least one matrix material, and that the particle has a sphericity from 0.800 to 0.999, as well as to a process for preparing said particle as well as to a food and/or feed additive containing said particle and optionally at least one further component. 2. The particle according to claim 1 , wherein the essential oils and/or plant extracts both being obtained from a plant selected from the group of oregano claim 1 , thyme claim 1 , caraway claim 1 , marjoram claim 1 , mint claim 1 , peppermint claim 1 , anise claim 1 , orange claim 1 , lemon claim 1 , fennel claim 1 , star anise claim 1 , ginger claim 1 , clove claim 1 , cinnamon claim 1 , wintergreen and garlic; or from an ingredient or compound of essential oils or plant extracts-preferably selected from the group of trans-anethole claim 1 , D-limonene claim 1 , γ-terpinene claim 1 , p-cymene claim 1 , 2-carene claim 1 , linalool oxide claim 1 , isomenthone claim 1 , camphor claim 1 , linalool claim 1 , terpinen-4-ol claim 1 , 2-isopropyl-1-methoxy-4-methylbenzene claim 1 , L-menthol claim 1 , ethylamine claim 1 , α-terpineol claim 1 , β-caryophyllene claim 1 , D-carvone claim 1 , methyl salicylate claim 1 , α-caryophyllene claim 1 , lavandulyl acetate claim 1 , caryophyllene oxide claim 1 , eugenol claim 1 , thymol and carvacrol.3. The particle according to claim 1 , wherein the particle has a sphericity ...

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21-01-2021 дата публикации

ENCAPSULATED MICRONUTRIENT GRANULES FOR FORTIFICATION OF EDIBLE SALT COMPOSITIONS

Номер: US20210015135A1
Принадлежит:

Substantially encapsulated micronutrient granules for fortification of an edible salt composition are disclosed. Said encapsulated micronutrient granules comprise granules comprising 0.1 to 20% of at least one micronutrient and 1 to 99% of at least one binding agent selected from a group consisting of a fatty acid, cellulose derivative and sugar, encapsulated by an outer coating comprising a fatty acid and cellulose derivative. 1. Substantially encapsulated micronutrient granules for fortification of an edible salt composition , said encapsulated micronutrient granules comprising:granules comprising 0.1 to 20% of at least one micronutrient and 1 to 99% of at least one binding agent selected from a group consisting a fatty acid, cellulose derivative and sugar, encapsulated by an outer coating comprising a fatty acid and cellulose derivative.2. The encapsulated micronutrient granules as claimed in claim 1 , wherein the outer coating comprises the fatty acid and cellulose derivative in a ratio ranging between 5:1 to 1:5.3. The encapsulated micronutrient granules as claimed in claim 1 , wherein the fatty acid is stearic acid.4. The encapsulated micronutrient granules as claimed in claim 1 , wherein the cellulose derivative is hydroxyl propyl methyl cellulose.5. The encapsulated micronutrient granules as claimed in claim 1 , having a particle size in a range of 200 to 800 microns.6. The encapsulated micronutrient granules as claimed in claim 1 , wherein the micronutrient is selected from a group consisting of Fe source claim 1 , Zn source and mixtures thereof.7. A fortified edible salt composition comprising:98% of an edible salt;{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '0.1 to 5% of encapsulated micronutrient granules as claimed in ; and'}0.01 to 0.5% of an additional micronutrient selected from a group consisting of potassium iodate, potassium iodide, and mixtures thereof.8. A process for preparing substantially encapsulated micronutrient granules claim 1 , ...

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21-01-2021 дата публикации

METHOD FOR PREPARING DOUBLE-LAYERED BURSTING BEADS WITH MILK TEA FLAVOR

Номер: US20210015142A1
Принадлежит:

The present invention provides a method for preparing double-layered bursting beads with milk tea flavor comprising: preparing inner and/or outer shell forming solutions for inner and/or outer shells of the bursting beads; preparing inner and/or outer core material solutions for inner and/or outer core materials of the bursting beads; preparing inner and/or outer shell curing solutions for inner and/or outer shells of the bursting beads; adding the inner core material solution into the inner shell forming solution, incubating, curing in the inner shell curing solution, and filtering to obtain inner bursting beads; and adding the inner bursting beads and the outer core material solution into the outer shell forming solution, and curing in the outer shell curing solution to obtain the double-layered bursting beads. The present invention improves bursting ability, densification, product instability due to complex browning and precipitation between tea polyphenol and protein during storage, and mechanical properties thereof. 1. A method for preparing double-layered bursting beads with milk tea flavor comprising:preparing an inner and/or outer shell forming solutions for the inner and/or outer shells of the bursting beads;preparing an inner and/or outer core material solutions for the inner and/or outer core materials of the bursting beads;preparing an inner and/or outer shell curing solutions for the inner and/or outer shells of the bursting beads;adding the inner core material solution into the inner shell forming solution, incubating, and curing in the inner shell curing solution, followed by filtering to obtain inner bursting beads; andadding the inner bursting beads and the outer core material solution into the outer shell forming solution, curing in the outer shell curing solution to obtain the double-layered bursting beads.2. The method of claim 1 , wherein said preparing the inner and/or outer shell forming solutions comprises dissolving at least one alginate and ...

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16-01-2020 дата публикации

ADMINISTRATION AND DOSAGE OF DIAMINOPHENOTHIAZINES

Номер: US20200016165A1
Принадлежит:

The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels. 2. (canceled)3. A method as claimed in wherein the total daily dosage is 2 to 15 mg; or 3 to 10 mg.411-. (canceled)1314-. (canceled)16. A method as claimed in wherein the or each protic acid is an inorganic acid.1718-. (canceled)19. A method as claimed in wherein the or each protic acid is an organic acid.20. A method as claimed in wherein the or each protic acid is selected from HCO claim 19 , CHCOOH claim 19 , methanesulfonic acid claim 19 , 1 claim 19 ,2-ethanedisulfonic acid claim 19 , ethansulfonic acid claim 19 , naphthalenedisulfonic acid claim 19 , and p-toluenesulfonic acid.22. A method as claimed in wherein the total daily dose of LMTM is around 0.8 to 33 mg/day claim 21 , more preferably 6 to 12 mg/day of LMTM total.23. A method as claimed in wherein the dose of LMTM is around 9 mg/once per day; 4 mg b.i.d.; 2.3 mg t.i.d.2537-. (canceled)3940-. (canceled)41. A method as claimed in wherein the subject has not historically received treatment with an acetylcholinesterase inhibitor or an N-methyl-D-aspartate receptor antagonist.42. A method as claimed in any one of wherein the subject has historically received treatment with an acetylcholinesterase inhibitor and\or an N-methyl-D-aspartate receptor antagonist claim 1 , but ceased that medication at least 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , 6 claim 1 , 7 claim 1 , or 8 weeks prior to treatment with the MT containing compound.43. A method as claimed in wherein the subject is selected as one who is receiving treatment with an acetylcholinesterase inhibitor and\or an N-methyl-D-aspartate receptor antagonist claim 1 ,wherein said treatment with the acetylcholinesterase ...

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16-01-2020 дата публикации

Foods Containing Beneficial Oral Bacteria

Номер: US20200016219A1
Автор: Christine Koski
Принадлежит: Probiora Health LLC

Compositions and methods are described that provide controlled release of stabilized bacteria into the oral cavity on consumption of a food, candy, gum, or similar substance so as to promote colonization of oral surface by the bacteria. Bacteria are selected to treat an oral condition, such as oral disease, halitosis, and/or stained enamel on consumption of the food.

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26-01-2017 дата публикации

Nutritionally and Botanically Enhanced Microbial/Bacterial Biomass

Номер: US20170020178A1
Автор: Rubin Jordan Seth
Принадлежит:

The present invention is an improved probiotic nutritional supplement, in unit dosage form for animal or human consumption, and a method of preparing it. Any of the nutritionally appropriate bacteria, such as but not limited to are cultured in connection with novel, enhanced-nutrition media and, in many cases, the enhanced-nutrition media is retained in the end product after fermentation. The enhanced-nutritional media, for example, may contain one or more of a legume, aloe vera juice or other fruit or vegetable juice, turmeric, green tea—or one of many other media constituents that probiotic bacteria have not been cultured on or with previously, for the purpose of preparing unit dosage forms thereof. 1Bacillus subtilis, Bacillus subtilisNatto, Bacillus coagulans,Lactobacillus plantarum,Echinacea purpureaEchinacea augustifoliaEchinacea augustifoliaGymnema sylvestre. A method for enhancing the probiotic constituency of edible or fermented foods , comprising growing at least one bacterium selected from the group consisting of ssp and on a growth medium containing one or more of growth media selected from the group consisting of Kidney Bean; Pumpkin Seed; Fava Bean; Chia Seed; Green Split Pea; Flax Seed; Green Lentil; Garbanzo Bean; Hemp Seed; Black Bean; Mung Bean; Adzuki Bean; Sesame Seed; Cranberry Bean; Great Northern Bean; Lima Bean; Navy Bean; Pinto Bean; Black rice; Ashwaghandha; Cacao nibs; Purple Millet , Black Quinoa , Red Quinoa , Red Canihua , Cannabis Saliva/Indica flowers or leaves; Spirulina; Lemon Peel; Chili Pepper; Kelp; Alfalfa leaf; Watercress; Cilantro; Sage; Thyme; Parsley; Broccoli Seed; Mate; green Coffee Beans; Roasted Coffee Beans; Green Tea; Rhodiola; Siberian Ginseng; Sea Buckthorn Berry; Black Soy Bean; Olive leaf; Cabbage; Milk Thistle seed; Milk Thistle leaf; Turmeric; Bupleurum; Artichoke leaf; Dandelion leaf; Dandelion root; Hibiscus flower; Ginkgo leaf; Bacopa; Periwinkle; Peppermint; Hawthorn Berry; Cardamon; Garlic; Mung Bean; ...

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26-01-2017 дата публикации

Array of age-tailored nutritional formula with probiotics

Номер: US20170020179A1
Принадлежит: Nestec SA

The present invention relates to nutritional compositions which are specifically designed to address the needs of infants and young children of at least 2 years of age. In particular, the invention provides a set of nutritional compositions for infants and young children, each nutritional composition having varying probiotic content. The set of the invention is specifically aimed at providing an optimal amount of probiotics to infants and young children over time and at each specific age.

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10-02-2022 дата публикации

GASTRO-RESISTANT MICROENCAPSULATES, AND USES THEREOF TO STIMULATE IN-VIVO ILEAL GLP-1 RELEASE IN A MAMMAL

Номер: US20220040258A1
Автор: Bleiel Sinead
Принадлежит: NUABIOME LIMITED

A cold-gelated mono-nuclear microencapsulate comprises a unitary liquid core encapsulated within a gastro-resistant, ileal-sensitive, polymerized denatured protein membrane shell, wherein the liquid core comprises a GLP-1 release stimulating agent in a substantially solubilised form. The GLP-1 release stimulating agent is a native protein selected from native dairy protein, native vegetable protein or native egg protein. 1. A mono-nuclear microencapsulate comprising a core material encapsulated within a gastro-resistant , ileal-sensitive , polymerized protein membrane shell , wherein the core material comprises a GLP-1 release stimulating agent selected from the group consisting of native dairy protein , native vegetable protein , native egg protein , disaccharide , or a mixture thereof , in a substantially solubilised form.2. (canceled)3. The mono-nuclear microencapsulate as claimed in in which the GLP-1 release stimulating agent is native pea protein.4. The mono-nuclear microencapsulate as claimed in in which the core material has a GLP-1 release stimulating agent concentration of 6-8% (w/v).5. The mono-nuclear microencapsulate as claimed in in which the protein of the membrane shell is selected from the group consisting of whey protein isolate claim 1 , whey protein concentrate claim 1 , milk protein concentrate claim 1 , or pea protein isolate.6. The mono-nuclear microencapsulate as claimed in in which the core material forms at least 50% of the microencapsulate (v/w).7. The mono-nuclear microencapsulate as claimed in in which the core material forms 70-95% of the microencapsulate (v/w).8. (canceled)9. The mono-nuclear microencapsulate as claimed in in which the core material comprises 7-9% native protein (w/v).10. The mono-nuclear microencapsulate as claimed in in which the core material comprises disaccharide.11. A composition suitable for oral administration to a mammal comprising a multiplicity of mono-nuclear microencapsulates according to .1216-. (canceled ...

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24-01-2019 дата публикации

MICROCAPSULES CONTAINING AN OXIDIZABLE ACTIVE, AND A PROCESS FOR PREPARING THE SAME

Номер: US20190022058A1
Принадлежит:

Disclosed is a microcapsule including a core having an oxidizable active (OA), the outer part of said core being in a solid form, and a water insoluble coating obtained from an encapsulating agent (EA), with the coating surrounding said core. In particular, the EA can be water soluble or organic solvent soluble, in particular in ethanol. The microcapsule can also include an EA in which the water solubility is pH-dependent. Also, the core does not contain a metal oxide, and the coating does not include a disintegrant, such as sodium starch glycolate. Also disclosed is a process for preparing the microcapsules. 1. A microcapsule consisting of or comprising:a core consisting of or comprising an oxidizable active (OA), the outer part of said core being in a solid form, anda water insoluble coating obtained from an encapsulating agent (EA), said coating surrounding said core,wherein said EA is water soluble, organic solvent soluble, or an agent having a water solubility that is pH-dependent,wherein said OA is selected from the group consisting of dihydroxyacetone, omega 3 oil and omega 6 oil,with the proviso that:said core does not comprise a metal oxide, andsaid coating does not comprise a disintegrant.2. The microcapsule according to claim 1 , wherein said EA is water soluble or organic solvent soluble and said water insoluble coating is induced by one ofan agent chemically reacting with said EA,an acid, a base, or a buffer for adjusting pH of said EA, anddrying of said EA.3. The microcapsule according to claim 1 , wherein said coating is such that claim 1 , when said microcapsule is placed in an alimentary claim 1 , cosmetically or pharmaceutically acceptable medium:said OA is not degraded by element(s) of said medium, andsaid element(s) of the medium is (are) not degraded by said OA.4. The microcapsule according to claim 1 , wherein said coating has a mass within the range from 3 to 50% of the total mass of said microcapsule.5. The microcapsule according to claim 1 , ...

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24-01-2019 дата публикации

GASTRO-RESISTANT MICROENCAPSULATES, AND USES THEREOF TO STIMULATE IN-VIVO ILEAL GLP-1 RELEASE IN A MAMMAL

Номер: US20190022180A1
Автор: Bleiel Sinead
Принадлежит: ANABIO TECHNOLOGIES LIMITED

A cold-gelated mono-nuclear microencapsulate comprises a unitary liquid core encapsulated within a gastro-resistant, ileal-sensitive, polymerized denatured protein membrane shell, wherein the liquid core comprises a GLP-1 release stimulating agent in a substantially solubilised form. The GLP-1 release stimulating agent is a native protein selected from native dairy protein, native vegetable protein or native egg protein. 1. A mono-nuclear microencapsulate comprising a core material encapsulated within a gastro-resistant , ileal-sensitive , polymerized denatured protein membrane shell , wherein the core material comprises a GLP-1 release stimulating agent selected from the group consisting of native dairy protein , native egg protein , native vegetable protein , or disaccharide , in a substantially solubilised form.2. (canceled)3. The mononuclear microencapsulate of wherein the GLP-1 stimulating release agent is native pea protein.4. The mononuclear microencapsulate of wherein the core material has a GLP-1 stimulating agent concentration of 6-8% (w/v).5. The mononuclear microencapsulate wherein the protein of the membrane shell is selected from the group consisting of whey protein isolate claim 1 , whey protein concentrate claim 1 , milk protein concentrate claim 1 , and pea protein isolate.6. The mononuclear microencapsulate of wherein the core material forms at least 50% of the microencapsulate (v/w).7. The mononuclear microencapsulate of wherein the core material forms 70-95% of the microencapsulate (v/w).8. The mononuclear microencapsulate of wherein the core material comprises surfactant.9. The mononuclear microencapsulate of wherein the core material comprises 7-9% native protein (w/v).10. The mononuclear microencapsulate of wherein the core material comprises disaccharide.11. A composition suitable for oral administration to a mammal comprising a multiplicity of microencapsulates of .12. The composition of selected from the group consisting of: a food product ...

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28-01-2021 дата публикации

Hydrocarbon / lipid - carotenoid complexes

Номер: US20210023223A1
Автор: Ivan Petyaev
Принадлежит: IP Science Ltd

The invention relates to uses of hydrocarbon/lipid complexes with carotenoids for improvement properties of hydrocarbon-based products as well as related methods and uses.

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02-02-2017 дата публикации

PROTEIN-BASED ENTERIC COATING FOR ORAL DOSAGE FORMS

Номер: US20170027876A1
Автор: Caillard Romain
Принадлежит: 9286-3620 QUEBEC INC.

The use of chemically modified proteins as enteric or gastroresistant coatings for oral dosage forms containing an active ingredient is described. Typical enteric coatings are made from synthetic polymers and function by acting as a barrier to gastric medium penetration. In some cases, the manufacture of such coatings requires the use of hazardous chemicals and the safety of some of the synthetic polymers that have been used in enteric coatings have been questioned. Protein-based enteric coatings of the present description present a more natural alternative to enteric coatings produced from synthetic polymers to provide gastroresistance to oral dosage forms. Protein-based film-forming solutions and uses thereof in coating oral dosage forms are also provided. 1. An enterically coated oral dosage form comprising a core comprising at least one active ingredient , wherein the core is enterically coated with a chemically modified protein , wherein the chemically modified protein comprises:(a) a chemical modification that causes a decrease in isoelectric point (pI) below that of the corresponding unmodified protein;(b) a chemical modification that causes a decrease in solubility at acidic pH as compared to that of the corresponding unmodified protein; and/or(c) a chemical modification that increases the ability of the protein to resist degradation by pepsin when in film-form, as compared to that of the corresponding unmodified protein.2. (canceled)3. The enterically coated oral dosage form of claim 1 , wherein the decrease in pI is a decrease of 0.1 claim 1 , 0.2 claim 1 , 0.3 claim 1 , 0.4 claim 1 , 0.5 claim 1 , 0.6 claim 1 , 0.7 claim 1 , 0.8 claim 1 , 0.9 claim 1 , 1 claim 1 , 1.5 claim 1 , 2 claim 1 , 2.5 claim 1 , or 3 units claim 1 , below that of the corresponding unmodified protein.4. (canceled)5. (canceled)6. The enterically coated oral dosage form of claim 1 , wherein the chemically modified protein is chemically modified by succinylation claim 1 , octenyl- ...

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01-02-2018 дата публикации

MICROCAPSULES COMPRISING LUTEIN OR LUTEIN ESTER

Номер: US20180027834A1
Принадлежит:

The invention relates to microcapsules comprising at least one active substance selected from lutein and lutein esters embedded in a matrix comprising gum acacia and optionally one or more other matrix components, wherein the content of said at least one active substance calculated as free lutein is from 0.5 to 25% of total weight of the microcapsule, and which microcapsule does not comprise any added emulsifier. 118.-. (canceled)19. A microcapsule comprising at least one active substance selected from lutein and lutein esters embedded in a matrix comprising native gum acacia and optionally one or more other matrix components , wherein the content of said at least one active substance calculated as free lutein is from 0.5 to 25% of total weight of the microcapsule , and which microcapsule does not comprise any added emulsifier.20. The microcapsule according to claim 19 , wherein the content of said at least one active substance calculated as free lutein is from 1 to 20% of total weight of the microcapsule.21. The microcapsule according to claim 19 , wherein the content of said at least one active substance calculated as free lutein is from 3 to 15% of total weight of the microcapsule.22. The microcapsule according to claim 19 , wherein the content of said at least one active substance calculated as free lutein is from 4 to 13% of total weight of the microcapsule.23. The microcapsule according to claim 19 , wherein the content of said at least one active substance calculated as free lutein is from 5 to 10% of total weight of the microcapsule.24. The microcapsule according to further comprising at least one antioxidant and/or plasticizer.25. The microcapsule according to claim 19 , wherein said gum acacia is a quality gained from Acacia Senegal.26. The microcapsule according to prepared from an emulsion of melted or dissolved lutein or lutein ester concentrate(s) in an aqueous solution of said native gum acacia in the absence of an emulsifier claim 19 , wherein said ...

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24-04-2014 дата публикации

Chewable soft capsule shell and chewable soft capsule

Номер: US20140112982A1

The present invention relates to a chewable soft capsule shell and a chewable soft capsule, and to a filled jelly sweet and a process for preparing a chewable soft capsule shell or filled jelly sweet, wherein the chewable soft capsule shell comprises gelatin 10%-50%, water retention agent 10%-40%, thickening agent 2%-20%, water 6%-20%, and said soft capsule shell has a thickness of 0.3-1.2 mm.

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01-02-2018 дата публикации

MICROCAPSULES COMPRISING LUTEIN OR LUTEIN ESTER

Номер: US20180027865A1
Принадлежит:

The invention relates to a microcapsule comprising at least one active substance selected from lutein and lutein esters embedded in a matrix comprising fish gelatine and optionally one or more other matrix components, wherein the content of said at least one active substance calculated as free lutein is from 0.5 to 25% of total weight of the microcapsule, and which microcapsule does not comprise any added emulsifier. 117.-. (canceled)18. A microcapsule comprising at least one active substance selected from lutein and lutein esters embedded in a matrix comprising fish gelatine , and optionally one or more other matrix components , wherein the content of said at least one active substance calculated as free lutein is from 0.5 to 25% of total weight of the microcapsule , and which microcapsule does not comprise any added emulsifier.19. The microcapsule according to claim 18 , wherein the fish gelatin is a low bloom fish gelatin.20. The microcapsule according to claim 18 , wherein the content of said at least one active substance calculated as free lutein is from 1 to 20% of total weight of the microcapsule.21. The microcapsule according to claim 18 , wherein the content of said at least one active substance calculated as free lutein is from 3 to 15% of total weight of the microcapsule.22. The microcapsule according to claim 18 , wherein the content of said at least one active substance calculated as free lutein is from 4 to 13% of total weight of the microcapsule.23. The microcapsule according to claim 18 , wherein the content of said at least one active substance calculated as free lutein is from 5 to 10% of total weight of the microcapsule.24. The microcapsule according to further comprising at least one antioxidant and/or plasticizer.25. The microcapsule according to claim 18 , wherein said fish gelatin is a fish gelatine having a strength of 30 bloom or less.26. The microcapsule according to claim 18 , wherein said fish gelatin is a fish gelatine having a strength ...

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17-02-2022 дата публикации

STABLE, SPRAY-DRIED PARTICLES AND PROCESS FOR OBTAINING SAME

Номер: US20220046961A1
Принадлежит:

Stable spray-dried particles are provided. The stable spray-dried particles include a water-soluble matrix including from about 5% to about 30% emulsifier; from about 20% to about 75% filler; and from 20% to about 50% mono, di and trisaccharides, based on the total weight of the matrix; and at least one active component encapsulated in the matrix. The emulsifier is dextrin and the filler is potato maltodextrin. 1. Stable spray-dried particles comprising:a water-soluble matrix including from 5% to 30% emulsifier; from 20% to 75% filler; andfrom 20% to 50% mono, di and trisaccharides, based on the total weight of the matrix; andat least one active component encapsulated in the matrix;wherein the emulsifier is dextrin and the filler is potato maltodextrin.2. The stable spray-dried particles according to claim 1 , wherein the dextrin is derived from corn.3. The stable spray-dried particles according to claim 1 , wherein the emulsifier is present in an amount of from 10% to 20% claim 1 , based on the total weight of the matrix.4. The stable spray-dried particles according to claim 1 , wherein the at least one active component is selected from the group consisting of flavour and fragrance ingredients.5. The stable spray-dried particles according to claim 4 , wherein the at least one active component is present in an amount of from 1% to 30% claim 4 , based on the total weight of the matrix.6. The stable spray-dried particles according to claim 1 , wherein at least 50% of the mono claim 1 , di and trisccharides is disaccharide.7. The stable spray-dried particles according to claim 1 , wherein 100% of the mono claim 1 , di and trisccharides is sucrose.8. The stable spray-dried particles according to claim 4 , wherein the at least one active component is a citrus oil.9. A delivery system comprising the stable spray-dried particles according to .10. A consumable comprising the stable spray-dried particles according to .11. The stable spray-dried particles according to claim 1 ...

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17-02-2022 дата публикации

EDIBLE PRODUCTS

Номер: US20220046971A1
Принадлежит:

The present invention relates to edible products, suitable for use as confectionery and having therapeutic uses. We describe a composition for the preparation of an edible product, the composition comprising 0.2 wt. % to 3 wt. % of at least one polysaccharide gelling agent, the balance being water. In preferred composition, the at least one polysaccharide is at least one of agar, pectin, locust bean gum, gellan gum and carrageenan. The compositions preferably comprise 0.5 wt. % to 2.00 wt. % agar and 0.05 to 1.0 wt. % of a galactomannan polysaccharide; the balance being water; preferably wherein the galactomannan polysaccharide is present in an amount of from 10% to 40% the amount of agar. 1. A composition for the preparation of an edible product , the composition comprising 0.2 wt. % to 3 wt. % of at least one polysaccharide gelling agent , the balance being water.2. A composition as claimed in wherein the at least one polysaccharide gelling agent is one or more of agar claim 1 , pectin claim 1 , locust bean gum claim 1 , gellan gum claim 1 , carrageenan claim 1 , guar gum claim 1 , konjac claim 1 , glean gum claim 1 , gum Arabic claim 1 , Xanthan gum; alginate claim 1 , arabinoxylan claim 1 , arrowroot claim 1 , carboxymethylcellulose claim 1 , cassia gum claim 1 , cellulose claim 1 , curdlan claim 1 , gellan claim 1 , guar gum claim 1 , gum Arabic claim 1 , karaya gum claim 1 , konjac claim 1 , kuzu claim 1 , marshmallow root claim 1 , pectin claim 1 , starch claim 1 , xanthan gum and b-glucan.3. A composition as claimed in or further comprising gelatine in an amount of up to 1.5 wt. %.4. A composition as claimed in any preceding claim wherein the at least one polysaccharide is at least one of agar claim 1 , pectin claim 1 , locust bean gum claim 1 , gellan gum and carrageenan.5. A composition as claimed in any preceding claim comprising 0.5 wt. % to 2.00 wt. % agar and 0.05 to 1.0 wt. % of a galactomannan polysaccharide; the balance being water; preferably ...

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31-01-2019 дата публикации

QUICK DROP AND DRINK NUTRITION AND MACHINE FOR MANUFACTURING THE SAME

Номер: US20190029291A1
Автор: Singer Nicholas J.
Принадлежит:

A water soluble shell or binder is used to encapsulate nutrients, flavoring, other food grade ingredients or combinations thereof together as a single serving or unit. The unit or single serving may be distributed to people to provide nutrition to people in mass casualty situations. In this manner, more nutrients may be delivered since water which has a significant amount of weight and volume need not be transported to the people. Moreover, in normal situations, the water soluble shell or binder dissolves sufficiently quick so that the user can quickly consume nutrients. 1. A method of manufacturing a solid form having a binder and an ingestible food product for conveniently mixing the ingestible food product with drinkable water , the method comprising the steps of:providing the ingestible product as a plurality of granules or powder;providing an ingestible water dissolvable binder that is dissolvable in 80 degree Fahrenheit water in under 10 minutes when the ingestible water dissolvable binder is submersed under water and the water is still;mixing the ingestible water dissolvable binder and the powdered ingestible food product;filling a cavity of a die with the mixed ingestible water dissolvable binder and powdered ingestible food product;binding the powered ingestible food product into the solid form with the ingestible water dissolvable binder.2. The method of wherein a dimension of the cavity is so that a width of the solid form is smaller than a mouth of a container and a length of the solid form is shorter than a height of the container.3. The method of wherein the ingestible food product is sugar claim 1 , flavor claim 1 , protein or combinations thereof.4. The method of wherein the ingestible water dissolvable binder is cellulose based claim 1 , rice based.5. The method of wherein the ingestible water dissolvable binder is provided in a liquid form.6. The method of wherein the food product is a flavor claim 1 , sugar claim 1 , protein claim 1 , carbohydrate ...

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31-01-2019 дата публикации

COATING METHOD OF LACTIC ACID BACTERIA WITH INCREASED INTESTINAL SURVIVAL RATE

Номер: US20190029311A1
Принадлежит:

This application relates to a coating method of lactic acid bacteria and a lactic acid bacteria complex produced by the coating method, the coating method comprising: (a) a step of culturing lactic acid bacteria in a medium including casein and coating the lactic acid bacteria with casein; (b) a step of mixing the casein-coated lactic acid bacteria with a solution comprising a coating agent, an edible oil, an extracellular polymeric substance (EPS) of and alginic acid; and (c) a step of adding the mixture of step (b) to a calcium-containing solution to form alginic acid-calcium beads, wherein the alginic acid-calcium beads contain the casein-coated lactic acid bacteria, the coating agent, the edible oil, and the EPS of 1. A method for coating a lactic acid bacterium , comprising:(a) culturing a lactic acid bacterium in a medium containing casein to coat the lactic acid bacterium with the casein;{'i': 'Lactobacillus plantarum,', '(b) mixing the casein-coated lactic acid bacterium with a solution comprising a coating agent, an edible oil or fat, extracellular polymeric substances (EPSs) of and alginic acid; and'}(c) adding the mixture to a calcium-containing solution to form calcium alginate beads,{'i': 'Lactobacillus plantarum.', 'Wherein the calcium alginate beads contain the casein-coated lactic acid bacterium, the coating agent, the edible oil or fat, and the EPSs of'}2LactobacillusBifidobacteriumStreptococcusLactococcusEnterococcusPediococcusLeuconostocWeissella. The method for coating a lactic acid bacterium according to claim 1 , wherein the lactic acid bacterium comprises at least one bacterial species selected from the group consisting of sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , sp. claim 1 , and sp.3Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Streptococcus faecalis,Lactococcus lactislactis.. ...

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30-01-2020 дата публикации

FAT-SOLUBLE NUTRIENT MICROCAPSULE AND PREPARATION METHOD THEREOF

Номер: US20200029596A1
Принадлежит:

The present invention discloses a fat-soluble nutrient microcapsule and a preparation method thereof. The fat-soluble nutrient microcapsule comprises the following components in percentage by weight: a fat-soluble nutrient (0.2-51.6%), an antioxidant (0.2-5.0%), a wall material (41.4-97.6%) and a moisture (2.0-5.0%) and the ratio of the fat-soluble nutrient that keeps active in the fat-soluble nutrient microcapsule to the fat-soluble nutrient that is initially added is 0.990-0.997:1. The preparation method of the fat-soluble nutrient microcapsule comprises an emulsification process and a granulation process, wherein the emulsification is performed in a cavitation emulsifier. By the preparation method, the nutrient active substance of the fat-soluble nutrient microcapsule has less lost and high stability. 2. The fat-soluble nutrient microcapsule according to claim 1 , characterised in that the fat-soluble nutrient is selected one or more from vitamin A derivatives claim 1 , vitamin E derivatives claim 1 , vitamin D claim 1 , carotenoid claim 1 , and coenzyme Q.3. The fat-soluble nutrient microcapsule according to claim 2 , characterised in that the fat-soluble nutrient is selected one or more from vitamin A acetate claim 2 , vitamin A palmitate claim 2 , vitamin E acetate claim 2 , vitamin E palmitate claim 2 , vitamin D2 claim 2 , vitamin D3 claim 2 , β-carotenoid claim 2 , astaxanthin claim 2 , lycopene claim 2 , canthaxanthus claim 2 , lutein and coenzyme Q10.4. The fat-soluble nutrient microcapsule according to claim 1 , characterised in that the antioxidant is selected one or more from propyl gallate claim 1 , BHT claim 1 , tea polyphenol claim 1 , α-tocopherol claim 1 , L-ascorbic acid-6-palmitate claim 1 , tea polyphenol palmitate claim 1 , sodium ascorbate claim 1 , ascorbic acid claim 1 , dilauryl thiodipropionate and lipoic acid; and preferably claim 1 , the antioxidant is a water-soluble antioxidant comprising one or more of ascorbic acid claim 1 , sodium ...

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30-01-2020 дата публикации

NUTRITIONAL SUPPLEMENT CONTAINING IRON

Номер: US20200030393A1
Принадлежит:

A nutritional supplement containing fungal biomass having at least 100 mg/kg iron and processes for producing the nutritional supplement using filamentous fungi are described. 1. A process for forming an iron supplement suitable for human consumption , the process comprising:providing a culture medium comprising an agricultural by-product or a food processing by-product with inorganic iron salts or iron compounds to provide at least 100 mg/L iron to the culture medium;{'i': Aspergillus oryzae', 'Aspergillus niger, 'culturing filamentous fungi selected from or in the culture medium to accumulate iron in the filamentous fungi in organic form; and'}harvesting the filamentous fungi containing iron to form an iron supplement containing fungal biomass having at least 2000 mg/kg iron in organic form.2. The process according to wherein the inorganic iron salts or iron compounds provide at least 200 mg/L iron to the culture medium.3. The process according to wherein the inorganic iron salts or iron compounds provide at least 1000 mg/L iron to the culture medium.4. The process according to wherein the inorganic iron salts or iron compounds provide at least 2000 mg/L iron to the culture medium.5. The process according to wherein the agricultural by-product is selected from the group consisting of condensed corn soluble (Syrup) claim 1 , corn process by-products claim 1 , wheat process by-products claim 1 , soybean process by-products claim 1 , and combinations thereof.6. The process according to wherein the agricultural by-product is Syrup.7. The process according to wherein the food processing by-product is selected from the group consisting of corn steeping liquor claim 1 , corn stillage claim 1 , soybean whey claim 1 , sugar cane and beet molasses claim 1 , soybean hull claim 1 , wheat bran claim 1 , wheat hull claim 1 , and combinations thereof.8. The process according to wherein the inorganic iron salts or iron compounds are selected from the group consisting of ferric ...

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04-02-2021 дата публикации

Multiparticulate solid dosage form having an elastic texture

Номер: US20210030681A1
Автор: Jean-Claude Tritsch
Принадлежит: DSM IP ASSETS BV

The present invention relates to a multiparticulate solid dosage form ( 1 ) which has an elastic texture and which contains a plurality of microcapsules ( 2 ) having a core ( 2 a ) and a shell ( 2 b ) that are embedded in an edible matrix ( 3 ). Microcapsules ( 2 ) contain an active ingredient which may be a pharmaceutical drug and/or a micronutrient. The multiparticulate solid dosage form of the invention is obtainable by a method wherein a mixture comprising water, microcapsules and starch particles is casted. The starch particles swell or dissolve only after casting.

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31-01-2019 дата публикации

MASS PRODUCED, ALCOHOL-CONTAINING SPHERICAL BEAD WITH IMPROVED SHELF LIFE AND "POP"

Номер: US20190031987A1
Автор: Hollenkamp Steven J.
Принадлежит:

A shelf stable, substantially spherical food product measuring about 4-20 mm in average diameter. The food product has a thin, outer gelatinous shell that is edible and makes a “pop” when bit into along with an alcohol-containing purely liquid center fully encased by the thin outer shell, said liquid center containing from about 2 to 40% alcohol by volume. Following its manufacture by extrusion, this food product is stored in a jar with an aqueous solution containing liquid alcohol additives. Until it is opened, the contents of that jar are suitable for at least one year. Once that jar is opened, this food product has a shelf life of at least about 3 months. 1. A shelf stable , substantially spherical food product measuring about 8-20 mm in average diameter , said food product having:a thin, outer gelatinous shell that is edible and makes a “pop” when bit into; andan alcohol-containing purely liquid center fully encased by the thin outer shell, said liquid center containing from about 2 to 40% alcohol by volume,said spherical food product adapted for storing in a jar with an aqueous solution containing liquid alcohol additives for a shelf life of at least about 3 months after opening the jar.2. The spherical food product of claim 1 , which measures about 8-12 mm in average diameter.3. The spherical food product of wherein said liquid center contains about 10-20% alcohol by volume.4. The spherical food product of claim 1 , which is supplied with a natural or artificial flavor additive selected from the group consisting of: strawberry claim 1 , raspberry claim 1 , lychee claim 1 , blueberry and wildflower claim 1 , autumn apple claim 1 , peach claim 1 , maple and cranberry.5. The spherical food product of claim 1 , which is made as a mass-produced extrudate from a combination of a first solution that includes a solvent claim 1 , a multivalent salt claim 1 , one or more liquid alcohol additives claim 1 , a preservative and a thickening agent; with a second solution ...

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09-02-2017 дата публикации

ACID RESISTANT BANDING SOLUTION FOR ACID RESISTANT TWO PIECE HARD CAPSULES

Номер: US20170035699A1
Принадлежит: Capsugel Belgium NV

The present disclosure relates to acid resistant banding solutions for two piece hard capsules endowed with acid resistant properties, and methods of making and using acid resistant banding solutions. The present disclosure also relates, in part, to methods for banding such acid resistant capsules which provides an acid resistant seal between the capsule parts and achieves increased acid resistance in vitro. 1. A banded capsule dosage form comprising:a) an acid resistant, two piece hard capsule comprising a body and a cap;b) the body and the cap being telescopically engaged to encapsulate an active agent; andc) an acid resistant band around the two piece hard capsule that seals a gap between the body and the cap, the acid resistant band comprising at least one acid resistant polymer selected from hydroxypropyl methylcellulose phthalate (HPMCP), cellulose acetate phthalate (CAP), hydroxypropyl methylcellulose acetate succinate (HPMCAS), and mixtures thereof;wherein the banded capsule dosage form provides improved resistance to acid media relative to a non-banded, closed capsule dosage form, as evaluated using a United States Pharmacopeia (“USP”) disintegration method (Chapter 701) in pH 1.2 media.2. The banded capsule dosage form of wherein the two piece hard capsule comprises HPMC claim 1 , HPCMAS claim 1 , or CAP.3. The banded capsule dosage form according to claim 1 , wherein the acid resistant band was formed from a composition comprising at least one alkaline compound selected from sodium bicarbonate claim 1 , sodium carbonate claim 1 , potassium carbonate claim 1 , potassium bicarbonate claim 1 , sodium hydroxide claim 1 , tri sodium phosphate claim 1 , sodium perborate claim 1 , potassium hydroxide claim 1 , lithium hydroxide claim 1 , lithium carbonate claim 1 , lithium bicarbonate claim 1 , ammonium carbonate claim 1 , ammonium bicarbonate claim 1 , ammonium hydroxide claim 1 , ammonia claim 1 , and mixtures thereof.4. The banded capsule dosage form ...

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07-02-2019 дата публикации

AMORPHOUS COOLER DISPERSION COMPOSITION

Номер: US20190037897A1
Принадлежит: International Flavors & Fragrances Inc.

A composition containing one or more water-insoluble cooling agents, each having a water solubility of 2 mg/g or less, and being encapsulated in a water-soluble matrix including at least one water-soluble carbohydrate; and at least one emulsifier, and a method for producing the same are described. 1. A composition comprising one or more water-insoluble cooling agents , each having a water solubility of 2 mg/g or less , and being encapsulated in a water-soluble matrix comprising(a) at least one water-soluble carbohydrate; and(b) at least one emulsifier.2. The composition of claim 1 , wherein the water solubility of each of the one or more water-insoluble cooling agents is 1 mg/g or less.3. The composition of claim 1 , wherein the water solubility of each of the one or more water-insoluble cooling agents is 0.5 mg/g or less.4. The composition of claim 1 , further comprising a cooling enhancer.5. The composition of claim 1 , further comprising a liquid-absorbing powder material.6. The composition of claim 1 , wherein the at least one water-soluble carbohydrate comprises a modified starch claim 1 , a dextrin claim 1 , a sugar claim 1 , a sugar alcohol claim 1 , or a combination thereof.7. The composition of claim 1 , wherein the one or more water-insoluble cooling agents are in the form of a solid crystalline powder or viscous liquid at 20° C.8. A composition comprising by weight of the composition:(i) 5%-35% of one or more water-insoluble cooling agents, and (a) 10%-50% of one or more sugars or sugar alcohols;', '(b) 10%-60% of at least one water-soluble carbohydrate polymer;', '(c) 0.1%-10% of one or more emulsifiers; and', '(d) 0-10% of one or more liquid-absorbing materials., '(ii) a water-soluble matrix encapsulating the one or more water-insoluble cooling agents, in which the water-soluble matrix contains by weight of the composition9. The composition of claim 8 , further comprising a cooling enhancer.10. The composition of claim 8 , wherein the at least one water ...

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07-02-2019 дата публикации

SNACKING PRODUCT WITH CAPSAICIN OR ANALOGUE THEREOF

Номер: US20190038577A1
Принадлежит: Altria Client Services LLC

A zero-calorie to near-zero-calorie snacking product that, when consumed, provides a feeling of fullness prior to absorption of energy-providing food, i.e., pre-absorptive satiation is disclosed. The snacking product is based on the stimulation of vagal nerve endings in the gastro-intestinal tract by encapsulated capsaicin. The encapsulation of capsaicin avoids the burning sensation in the mouth which may be objectionable to some consumers. 130-. (canceled)31. A snacking product comprising: a flavor system that comprises encapsulated capsaicin , an encapsulated capsaicin analogue , or a combination thereof; wherein the snacking product is a zero-calorie to near-zero calorie snacking product; wherein the snacking product does not comprise capsiate; and wherein the flavor system further comprises food fibers.32. The snacking product of claim 31 , wherein the snacking product is configured to stimulate vagal nerve endings in a gastrointestinal tract.33. The snacking product of claim 32 , wherein the vagal nerve endings express the transient receptor potential cation channel subfamily receptor V member 1 (TRPV1) receptor.34. The snacking product of claim 32 , wherein the vagal nerve endings express the cholecystokinin (CCK) receptor.35. The snacking product of claim 31 , wherein the encapsulated capsaicin claim 31 , encapsulated capsaicin analogue claim 31 , or combination thereof is micro-encapsulated.36. The snacking product of claim 31 , wherein the flavor system further comprises Korean Pine Oil.37. The snacking product of claim 31 , wherein the snacking product is an energy drink claim 31 , an energy bar claim 31 , a dietary supplement claim 31 , a capsule claim 31 , a pill claim 31 , a lozenge claim 31 , a sub-combination thereof or a combination thereof.38. The snacking product of claim 31 , wherein the snacking product is located in a screw cap of a beverage container.39. The snacking product of claim 38 , wherein the snacking product is released upon opening of ...

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06-02-2020 дата публикации

Edible nutrition system, method of preparation and use thereof

Номер: US20200037655A1
Принадлежит: Individual

The present invention relates to an edible composition, particularly an edible nutrition system, comprising an edible filling material (2) and an edible outer shell material (1), and the use thereof for the provision and/or transportation of edible materials. Additionally, in some embodiments, the edible nutrition system comprises an edible or potable substance (3). Further, the disclosure relates to a method for preparing said edible nutrition system.

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03-03-2022 дата публикации

PROTECTION OF MICROBIAL CELLS FROM ACIDIC DEGRADATION

Номер: US20220062187A1
Принадлежит:

A simple cellulose sulphate based microencapsulation technology has been applied to encapsulate bacterial or other microbial cells, which produce and release digestive enzymes and thereby provides an acid resistant shelter for these microbial cells. Surprisingly, the resulting spheres were found to provide sufficient protection for encapsulated cells from treatment with aqueous acidic solutions. Thereby the cellulose sulphate microencapsulated cells, such as probiotics are now enabled to survive passage, for example, through the stomach after consumption by a human or animal with a higher survival rate than those not within a microcapsule. After passing the stomach these cells are delivering products produced by them, e.g. enzymes or other nutrition factors. This technology therefore proves to be very useful in providing digestive or otherwise beneficial enzymes and/or of living microbial cells, into the lower gastrointestinal tract, where they could confer their health benefit to the host.

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14-02-2019 дата публикации

Novel coating system (ii)

Номер: US20190045831A1
Принадлежит: DSM IP ASSETS BV

The present patent application relates to a novel coating system for coating solid particles, which comprise PUFAs (and/or salts thereof), wherein the coating comprises at least one protein hydrolysate. Furthermore it relates to compositions coated with such a coating system and the use of such compositions in the production of food, feed, dietary supplements and/or pharmaceutical products.

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13-02-2020 дата публикации

Pearl-like capsule and method of manufacturing the same

Номер: US20200045996A1
Принадлежит:

The invention aims to provide a pearl-like capsule that can encapsulate a large amount of fatty substances and a method of manufacturing the same, wherein the pearl-like capsule is less deformable and/or less shrinkable even under freeze-thaw and thus is convenient for transportation and preservation. The pearl-like capsule includes a droplet having an outer surface and a 0.5 millimeter to 15 millimeter diameter, and a water-soluble macromolecule, fatty substances, a water-soluble multivalent metallic salt, sake lees, and starch. The pearl-like capsule also includes a water-insoluble coating of alginate on the outer surface of the droplet, and a glycerine coating on the water-insoluble coating of alginate, wherein the sake lees include amino acid and are 1% to 10% by weight of the droplet, and the starch is 10% to 20% by weight of the droplet. 1. A pearl-like capsule comprising:a droplet having an outer surface, a 0.5 millimeter to 15 millimeter diameter, and including a water-soluble macromolecule, fatty substances, a water-soluble multivalent metallic salt, sake lees, and starch;a water-insoluble coating of alginate on the outer surface of the droplet; anda glycerine coating on the water-insoluble coating of alginate,wherein the sake lees derive from any sake selected from a group consisting of Junmai Daiginjo-shu, Daiginjo-shu, Junmai Ginjo-shu, Ginjo-shu, Special Junmai-shu, Junmai-shu, Tokubetsu Honjozo-shu, Honjozo-shu, and Futsu-shu,wherein the sake lees include amino acid,wherein the sake lees are 1% to 10% by weight of the droplet and the starch is 10% to 20% by weight of the droplet.2. The pearl-like capsule according to claim 1 , wherein said water-soluble macromolecule is a quince seed mucilage.3. The pearl-like capsule according to claim 1 , wherein said water-soluble multivalent metallic salt is water-soluble calcium salt.4. A method of manufacturing a pearl-like capsule 0.5 millimeters to 15 millimeters in diameter claim 1 , the method comprising: ...

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25-02-2021 дата публикации

Formulation of glucosinolates and myrosinase

Номер: US20210052618A1

A formulation includes microcapsules which contains a core containing an extract rich in glucosinolates obtained from crucifers and a biopolymer, and an enteric coating containing myrosinase and a biopolymer. A procedure is to obtain the same and to use the formulation as such, or in dietetic food supplements for humans or animals due to its immunostimulant activity.

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08-05-2014 дата публикации

Extruded delivery system

Номер: US20140127361A1
Принадлежит: FIRMENICH SA

The present invention relates to an extruded delivery system. It also relates to a process for preparing such a extruded delivery system.

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22-02-2018 дата публикации

MANUFACTURED FRUIT COMPOSITIONS AND METHODS OF MAKING

Номер: US20180049462A1
Принадлежит:

A food composition and method of making is provided, the food composition comprising a first structural food unit comprising an edible matrix encapsulating an edible substance that optionally comprises one or more thickening agents; a second structural food unit, between about 10 times and about 10times the size of the first structural food unit, comprising an edible hydrocolloid matrix encapsulating a first visco-elastic substance, the first visco-elastic substance comprising a soft food, xanthan gum, and galactomannan and a plurality of first structural food units, and wherein an outer surface of the first visco-elastic substance substantially adheres to an inner surface of the edible hydrocolloid matrix encapsulating the first visco-elastic substance. 1. A food composition , comprising:a first structural food unit comprising an edible matrix encapsulating an edible substance that optionally comprises one or more thickening agents;{'sup': '6', 'a second structural food unit, between about 10 times and about 10times the size of the first structural food unit, comprising an edible hydrocolloid matrix encapsulating a first visco-elastic substance, the first visco-elastic substance comprising a soft food, xanthan gum, and galactomannan and a plurality of first structural food units, and wherein an outer surface of the first visco-elastic substance substantially adheres to an inner surface of the edible hydrocolloid matrix encapsulating the first visco-elastic substance.'}2. The food composition of claim 1 , further comprising a third structural food unit claim 1 , between about 10 times and about 10times the size of the second structural food unit claim 1 , comprising an edible hydrocolloid matrix encapsulating a second visco-elastic substance claim 1 , the second visco-elastic substance comprising a soft food claim 1 , xanthan gum claim 1 , and galactomannan and a plurality of second structural food units claim 1 , and wherein an outer surface of the second visco- ...

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25-02-2021 дата публикации

POLYPEPTIDE AND IMMUNE MODULATION

Номер: US20210054031A1
Принадлежит:

The present invention relates to flagellin, and/or a polynucleotide sequence encoding said flagellin, and/or a vector comprising said polynucleotide sequence, and/or a host cell, including bacteria, comprising said vector, and/or a host cell, including bacteria, comprising said polynucleotide sequence, for use in modulating the inflammation of a tissue or an organ in a subject. 168-. (canceled)69Roseburia. A method of reducing inflammation in a subject in need thereof , comprising administering to the subject of a pharmaceutical composition that comprises an amount of a flagellin polypeptide sufficient to increase a level of IL-10 in the subject , relative to a level of IL-10 prior to the administering , thereby reducing inflammation.70Roseburia. The method of claim 69 , wherein the flagellin comprises a polypeptide sequence having at least 75% identity to the polypeptide sequence of SEQ ID NO: 2 claim 69 , as determined by a sequence alignment performed using BLAST.71. The method of claim 70 , wherein the polypeptide sequence comprises a region that has at least 75% identity to amino acids 79-117 of SEQ ID NO: 2 claim 70 , as determined by a sequence alignment performed using BLAST.72Roseburia. The method of claim 69 , wherein the flagellin comprises a polypeptide sequence having at least 80% identity to the polypeptide sequence of SEQ ID NO: 2 claim 69 , as determined by a sequence alignment performed using BLAST.73. The method of wherein the polypeptide sequence comprises a region that has at least 80% identity to amino acids 79-117 of SEQ ID NO: 2 claim 72 , as determined by a sequence alignment performed using BLAST.74Roseburia. The method of claim 69 , wherein the flagellin polypeptide comprises a polypeptide sequence having at least 85% identity to the polypeptide sequence of SEQ ID NO: 2 claim 69 , as determined by a sequence alignment performed using BLAST.75. The method of wherein the polypeptide sequence comprises a region that has at least 85% identity ...

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10-03-2022 дата публикации

BEVERAGES COMPRISING STABLE GRANULES OF MILLED LUTEIN

Номер: US20220071237A1
Принадлежит:

Beverages are provided which include a beverage liquid and granules mixed with the beverage liquid The granules include: 1. A beverage comprising a beverage liquid and granules mixed with the beverage liquid , wherein the granules comprise: D [3,2] in the range of from 0.6 to 1.5 μm, and', 'D [v, 0.5] in the range of from 1.1 to 3.5 μm,, '(i) a milled carotenoid consisting of lutein and/or zeaxanthin, wherein the milled carotenoid has the following particle size distribution(ii) a matrix material which encapsulates the milled carotenoid and comprises at least one modified food starch, a glucose syrup and sucrose, and(iii) a water-soluble antioxidant, wherein D [3,2] in the range of from 200 to 300 μm, and', 'D [v, 0.5] in the range of from 220 to 320 μm, and wherein, 'the granules have the following particle size distributionall D values are as measured by laser diffraction according to the Fraunhofer scattering model, and whereinthe granules do not include an oil or a gelatin.2. The beverage according to claim 1 , wherein the beverage is a soft drink having a pH in the range of from 2 to 5.3. The beverage according to claim 1 , wherein the beverage has a color stability DE* 1 for 60 days.4. The beverage according to claim 1 , wherein the beverage has a turbidity 150 NTU.5. The beverage according to claim 1 , wherein the amount of the milled carotenoid claim 1 , the amount of the modified food starch claim 1 , the amount of the glucose syrup claim 1 , the amount of sucrose and the amount of the water-soluble antioxidant are together at least 90 wt. % of the total weight of the granules.6. The beverage according to claim 1 , wherein the amount of the milled carotenoid claim 1 , the amount of the modified food starch claim 1 , the amount of the glucose syrup claim 1 , the amount of sucrose and the amount of the water-soluble antioxidant are together at least 95 wt. % of the total weight of the granules.7. The beverage according to claim 1 , wherein the amount of ...

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10-03-2022 дата публикации

EDIBLE NUTRITION SYSTEM, METHOD OF PREPARATION AND USE THEREOF

Номер: US20220071263A1
Принадлежит:

The present invention relates to an edible composition, particularly an edible nutrition system, comprising an edible filling material () and an edible outer shell material (), and the use thereof for the provision and/or transportation of edible materials. Additionally, in some embodiments, the edible nutrition system comprises an edible or potable substance (). Further, the disclosure relates to a method for preparing said edible nutrition system. 129.-. (canceled)30. A method of preparing an edible nutrition system , comprising:{'b': 3', '3, 'subjecting an edible or potable substance () to spherification to create a thermostable coating around the edible or potable substance ();'}{'b': '1', 'providing an edible outer shell material () in form of a bag;'}{'b': 1', '2, 'filling the bag of the edible outer shell material () with an edible filling material ();'}{'b': 3', '1, 'inserting the edible or potable substance () into the bag of the edible outer shell material ();'}{'b': 1', '1, 'closing the bag of the edible outer shell material () with further edible outer shell material ();'}{'b': '1', 'placing the closed bag of the edible outer shell material () into a baking form; and'}baking the edible nutrition system in one or more baking steps.31331. The method according to claim 30 , wherein the edible or potable substance () is frozen during inserting the edible or potable substance () into the bag of the edible outer shell material ().32. The method according to claim 30 , further comprising:{'b': 3', '2', '1, 'mixing the edible or potable substance () with the edible filling material () before inserting the mix thereof in the bag of outer shell material ().'}33. The method according to claim 30 ,{'b': 2', '2, 'wherein the edible filling material () is provided in one or more compartments of the edible filling material () and'}{'b': 3', '3, 'wherein the edible or potable substance () is provided in one or more compartments of the edible or potable substance ().'}34 ...

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10-03-2022 дата публикации

MICROENCAPSULATION METHOD FOR IMPROVING STABILITY OF ANTHOCYANIN, PRODUCT THERE-FROM AND USE THEREOF

Номер: US20220071914A1
Принадлежит:

The present invention discloses a microencapsulation method for improving stability of anthocyanin, a product therefrom and use thereof. A preparation method of anthocyanin microcapsules includes: (1) taking sodium alginate as a wall material, adding sodium alginate and calcium carbonate into water, and swelling for 1-2 h to obtain a wall material gel system; (2) taking anthocyanin prepared by a special process as a core material, and fully and uniformly mixing the wall material gel system with an anthocyanin solution to obtain a water phase; (3) mixing Span80 and vegetable oil to obtain an oil phase, mixing the water phase with the oil phase, and magnetically stirring for emulsifying to obtain a W/O emulsion; and (4) adjusting the pH of the W/O emulsion to be acidic, mixing the W/O emulsion with a salt buffer solution, standing for 1-2 h, and then separating the oil phase and the water phase. 1. A microencapsulation method for improving stability of anthocyanin , comprising the following steps:S1, taking sodium alginate as a wall material, respectively preparing sodium alginate, calcium carbonate and water according to a weight ratio of sodium alginate to calcium carbonate to water of (2-4):1:(15-25), and then adding the sodium alginate and the calcium carbonate into water to swell for 1-2 h to obtain a wall material gel system;S2, taking anthocyanin as a core material, and fully and uniformly mixing the wall material gel system with an anthocyanin solution for later use at a weight ratio of the sodium alginate to the anthocyanin of (12-20):1 to obtain a water phase;S3, mixing Span80 with vegetable oil at a volume ratio of (1-2):1 to obtain an oil phase, mixing the water phase with the oil phase at a volume ratio of (3-5):1, and magnetically stirring the mixture for emulsifying to obtain a W/O emulsion; andS4, adjusting the pH of the W/O emulsion to be acidic, mixing the W/O emulsion with a buffer solution at a volume ratio of 1:(3-5), standing for 1-2 h, and ...

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01-03-2018 дата публикации

DROPLET ASSEMBLIES AND METHODS FOR PRODUCING DROPLET ASSEMBLIES

Номер: US20180055084A1
Принадлежит:

Provided is a method for preparing an assembly of integrated capsules, the method comprising the steps of: (i) providing a first body comprising a body reagent, wherein the body reagent is, or is contained within, a body medium; (ii) contacting the first body with a bulk medium comprising a bulk reagent, and permitting a first capsule shell to form at the boundary between the body medium and the bulk medium, thereby providing a first capsule, wherein the shell comprises a product of a reaction involving the body reagent and the bulk reagent; (iii) providing a second body comprising a body reagent, wherein the body reagent is, or is contained within, a body medium; (iv) contacting the second body with a bulk medium comprising a bulk reagent, and permitting a second capsule shell to form at the boundary between the second body medium and the bulk medium, thereby providing a second capsule, wherein the shell comprises a product of a reaction involving the body reagent and the bulk reagent; and (v) permitting the first and second capsule shells to integrate, thereby forming an assembly of first and second bodies. An assembly obtained or obtainable by the method is also provided. 1. A method for preparing an assembly comprising a plurality of integrated capsules , the method comprising the steps of:(i) providing a first body comprising a body reagent, wherein the body reagent is, or is contained within, a body medium;(ii) contacting the first body with a bulk medium comprising a bulk reagent, and permitting a first capsule shell to form at the boundary between the body medium and the bulk medium, thereby providing a first capsule, wherein the shell comprises a product of a reaction involving the body reagent and the bulk reagent, such as ionic cross-linking;(iii) providing a second body comprising a body reagent, wherein the body reagent is, or is contained within, a body medium;(iv) contacting the second body with a bulk medium comprising a bulk reagent, and permitting ...

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21-02-2019 дата публикации

NOVEL COATING SYSTEM (I)

Номер: US20190053531A1
Принадлежит: DSM IP ASSETS B.V.

The present patent application relates to a novel coating system for coating solid particles, which comprise PUFAs (and/or salts thereof), wherein the coating comprises at least one cyclodextrin. Furthermore it relates to compositions coated with such a coating system and the use of such compositions in the production of food, feed, dietary supplements and/or pharmaceutical products. 1. A coating system comprisingat least 10 wt-%, based on the total weight of the coating system, of cyclodextrin.2. A coated composition comprising(a) a core, which is a sold formulation comprises at least one PUFA (and/or salts thereof) and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(b) a coating system according to .'}3. The coated composition according to claim 2 , comprising(a) 70 to 99.5 wt-%, based on the total weight of the composition, of core and(b) 0.5 to 30 wt-%, based on the total weight of the composition, of coating system.4. Process of production of a coated composition according claim 2 , wherein(i) the cores (which comprise PUFA (and/or salts thereof)) are produced by beadlet process, spray drying or spray-granulation in a first step;(ii) these cores (solid particles) are coating in a second step by a solution, dispersion or slurry of the coating material (cyclodextrin), and(iii) afterwards the coated particles are dried.5. Use of the coated particles according to in food products claim 2 , feed products claim 2 , dietary supplements and/or pharmaceutical products.6. Food products claim 2 , feed products claim 2 , dietary supplements and/or pharmaceutical products claim 2 , comprising at least one coated composition according to . The present patent application relates to a novel coating system for coating solid particles, which comprise PUFAs (and/or salts thereof), wherein the coating comprises at least one cyclodextrin. Furthermore it relates to compositions coated with such a coating system and the use of such compositions in the production of food, feed, ...

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02-03-2017 дата публикации

FORMULATION OF FAT-SOLUBLE VITAMIN

Номер: US20170056339A1
Принадлежит:

The invention relates to a composition comprising A) microcapsules comprising at least one fat-soluble active substance selected from a vitamin K compound or a provitamin or a prodrug of a vitamin K compound embedded in a matrix comprising a hydrocolloid and optionally one or more other matrix components, and B) at least one dietary mineral; as well as uses and products comprising such compositions. 132-. (canceled)33. A composition comprising:A) microcapsules comprising at least one fat-soluble active substance selected from a vitamin K compound or a provitamin or a prodrug of a vitamin K compound embedded in a matrix comprising a hydrocolloid and optionally one or more other matrix components; andB) at least one dietary mineral.34. The composition according to claim 33 , wherein said at least one fat-soluble active substance is vitamin K1 claim 33 , vitamin K2 claim 33 , provitamins and prodrugs of vitamin K1 or vitamin K2 claim 33 , MK-6 claim 33 , MK-7 claim 33 , MK-8 claim 33 , or a mixture thereof.35. The composition according to claim 33 , wherein the content of said active substance is from 0.01 to 15% claim 33 , 0.1 to 10% claim 33 , 0.2 to 5% claim 33 , or 1 to 3% of the total weight of the microcapsules.36. The composition according to claim 33 , wherein said at least one dietary mineral is a salt of Li claim 33 , Na claim 33 , Mg claim 33 , K claim 33 , Ca claim 33 , V claim 33 , Cr claim 33 , Mn claim 33 , Fe claim 33 , Co claim 33 , Ni claim 33 , Cu claim 33 , Zn claim 33 , Mo or Se.37. The composition according to claim 36 , wherein the at least one dietary mineral salt is:a) a pharmaceutically acceptable salt;b) a halide, oxide, nitrate, stearate, sulphate, carbonate, glycerophosphate, hydrogen carbonate, dihydro- or anhydro-phosphate;c) a calcium salt or a magnesium salt; ord) calcium carbonate or magnesium oxide.38. The composition according to claim 33 , wherein the content of said microcapsules is from 0.001 to 15% claim 33 , 0.01 to 10% claim 33 ...

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20-02-2020 дата публикации

Microencapsulated chitosan, methods of making and methods for the use thereof

Номер: US20200054572A1
Принадлежит: Primex ehf

Provided herein are microencapsulated chitosan materials and formulations containing same, methods of making such formulations, and methods of using such formulations. Application of a microencapsulation coating on chitosan materials and formulations containing same renders possible the use of chitosan materials for different, novel chitosan-based dietary applications with the primary aim to decrease intestinal absorption of fat and enhance overall health, without interfering with or reducing food palatability. The present invention provides methods to microencapsulate highly effective chitosan or chitosan salts to moderate their interaction with food components and mask any off-flavors and off-tastes but allow rapid chitosan solubilization under gastric acid conditions and simultaneous binding of ingested lipids. Chitosan contemplated for use herein is preferably of high quality with high fat-binding capacity, and its source is preferably of crustacean origin.

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22-05-2014 дата публикации

Method and compositions for producing hydrogel capsules coated for low permeability and physical integrity

Номер: US20140137878A1
Принадлежит: PHILIP MORRIS USA INC

Methods and compositions for producing hydrogel capsules enveloped with at least one coating layer is disclosed. The coating formulations deposited on the surface of the capsules can improve the physical integrity and the water-retention properties of the alginate beads. The coating formulations can be sequentially applied in various combinations to obtain desirable properties, such as improved physical integrity, mechanical strength, and low permeability, that can extend the shelf-life of the capsules when incorporated into various consumer products.

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28-02-2019 дата публикации

Pelletized Colorants Comprising a Pigment-Protein Complex and Food Products Including the Same

Номер: US20190059422A1
Принадлежит: Kraft Foods Group Brands LLC

According to embodiments, a dry powdered composition which may be reconstituted to provide a gelatin product includes powdered gelatin and a pelletized colorant. The pelletized colorant includes a pigment-protein complex and at least one encapsulating agent for encapsulating the pigment-protein complex. The pelletized colorant has a rate of dissolution a rate of dissolution of less than 2 grams/minute in water having an initial temperature of from about 95° C. to about 100° C. Methods of making food products with the pelletized colorant are also disclosed. In embodiments, when the food products are measured on the L*a*b* color space, the food products have an L* value of about 49 to about 57, an a* value of about −10 to about −16, and a b* value of from about −11 to about −20.5. 1. A colorant for a food product comprising:from about 0.1 wt % to about 40 wt % of a pigment-protein complex;from about 60 wt % to about 99.9 wt % encapsulating agent, the encapsulating agent encapsulating the pigment-protein complex in a pelletized colorant, the pelletized colorant having a rate of dissolution of less than 2 grams/minute in water having an initial temperature of from about 95° C. to about 100° C.2. The colorant of claim 1 , wherein the encapsulating agent is at least one of corn syrup claim 1 , honey claim 1 , mizaume claim 1 , molasses claim 1 , maple syrup claim 1 , agave claim 1 , fructo oligo accharides claim 1 , brown rice syrup claim 1 , liquid sugar claim 1 , invert syrups claim 1 , glycerin claim 1 , propylene glycol claim 1 , poly ethylene glycol claim 1 , 1 claim 1 ,3 propane diol.3. The colorant of claim 1 , wherein the encapsulating agent is at least one of an oil claim 1 , hydrocolloid gelling protein claim 1 , and alginate.4. The colorant of claim 1 , further comprising up to about 85 wt % dry diluent.5. The colorant of claim 4 , wherein the dry diluent is at least one of sucrose claim 4 , maltodextrin claim 4 , a granular sugar claim 4 , cyclodextrin claim 4 ...

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28-02-2019 дата публикации

COMPOSITION AND METHOD FOR TREATING MIGRAINES

Номер: US20190060357A1
Автор: Greene Donald J.
Принадлежит:

Disclosed are compositions for treating or preventing migraine headaches and related headaches. 1. A method of treating or preventing a migraine or stress headache in a subject , said method comprising administering to said subject a therapeutically effective amount of a pharmaceutical composition comprising: a riboflavin compound; a heavy metal; and an unsaturated fatty acid , wherein the combination of riboflavin , heavy metal , and fatty acid is effective to prevent or treat a migraine headache or stress headache when said formulation is ingested by said subject orally.2. The method of claim 1 , wherein said riboflavin compound is riboflavin claim 1 , riboflavinyl glucoside claim 1 , riboflavin 5′ phosphate claim 1 , riboflavin 5′ adenosine diphosphate claim 1 , a riboflavin acid ester claim 1 , a riboflavin butyrate claim 1 , a riboflavin sodium phosphate claim 1 , a riboflavin 5′-phosphate claim 1 , a sodium flavinadeninedinucleotide claim 1 , or a flavinmononucleotide.3. The method of claim 1 , wherein said riboflavin compound is riboflavin.4. The method of claim 1 , wherein said heavy metal is magnesium claim 1 , copper claim 1 , or zinc.5. The method of claim 1 , wherein said heavy metal is magnesium.6. The method of claim 5 , wherein said magnesium is assimilable magnesium.7. The method of claim 5 , wherein said magnesium is magnesium is provided as magnesium oxide or magnesium citrate.8. The method of claim 1 , wherein said heavy metal is chelated.9. The method of claim 1 , wherein said fatty acid is eicosapentaenoic acid (EPA) claim 1 , docosahexaenoic acid (DHA) claim 1 , or a combination of EPA and DHA.10. The method of claim 1 , wherein said fatty acid is provided as fish oil.11. The method of claim 9 , wherein said EPA or DHA is derived from fish oil.12. The method of claim 1 , wherein said formulation is free of other B complex vitamins.13. The method of claim 1 , wherein said formulation is free of other nutrients.14. The method of claim 1 , wherein ...

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27-02-2020 дата публикации

NANOFORMULATIONS CONTAINING ENCAPSULTED OMEGA-3 FATTY ACIDS

Номер: US20200060321A1
Принадлежит:

Disclosed is a method for making and using insoluble, biodegradable, nanoparticles containing the omega-3 fatty acids EPA and DHA in selected ratios. Tests show a surprising effect that the nanoformulation is twice as potent and at least five times more sustained leading to at least tenfold (2×5) higher bioavailability at equal dose (1% v/v). 1. A composition comprising an aqueous suspension of a nanoparticles that comprise at least one omega-3 fatty acid oil that is encapsulated by a coating agent , wherein said at least one fatty acid oil comprises eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) wherein the EPA and/or DHA are in a form chosen from ethyl ester , triglyceride and free fatty acid; wherein the fatty acid mixture particulates having an average particle size within the range of 25-1000 nm and that exhibits a polydispersity index (PDI) within the range of less than 0.50.2. A composition according to wherein the fatty acid oil is a mixture of EPA and DHA having a higher concentration by weight of EPA than DHA; the coating agent comprises a gelatin claim 1 , a gum derivative or a polymer; and the particulates further comprise one or more stabilizing agents or surfactants.3. A composition according to claim 2 , wherein the coating agent comprises a chitosan claim 2 , gelatin claim 2 , gliadin claim 2 , lectin-gliadin claim 2 , methacrylic acid/ethylacrylate co-polymer claim 2 , polypropylcyanoacrylate claim 2 , polylactic co-glyconic acid (PLGA) claim 2 , sulfobutylated polyvinylalcohol-PLGA claim 2 , lectin-PLGA claim 2 , polyethyleneglycolpolylactic acid claim 2 , polyethylenemethacrylate (PMMA) claim 2 , polymethylvinylether-co-maleic anhydride claim 2 , polyethylene oxide-polyoxypropylene (PEO-POP) claim 2 , poly(N-isopropylacrylamide) claim 2 , poly(N-vinylacetamide) claim 2 , poly(t-butylmethacrylate) claim 2 , polycaprolactone (PCL) claim 2 , polystyrene claim 2 , or hydroxypropylmethylcellulose phthalate.4. A composition according to ...

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08-03-2018 дата публикации

A METHOD FOR ENCAPSULATING ADDITIVES INTO SEEDS, BEANS, NUTS, CEREALS AND PSEUDO-CEREALS

Номер: US20180064157A1
Принадлежит:

The present invention discloses the use of subcritical or supercritical carbon dioxide for injecting additives to seeds, beans, nuts, cereals and pseudo-cereals. 1. A method for injecting additives to seeds , beans , nuts , cereals and pseudo-cereals comprising:a) charging an impregnation chamber with the seeds, beans, nuts, cereals and pseudo-cereals;b) preparing an impregnation fluid by mixing the desired additives, optionally with a solvent and at a volume ratio additives to solvent ranging between 1:0 and 1:200;{'sub': '2', 'c) injecting the impregnation fluid of step b) into the impregnation chamber under subcritical or supercritical COconditions, and contacting with the seeds, beans, nuts, cereals and pseudo-cereals of step a) for a period of time of at least 15 minutes;'}{'sub': '2', 'd) optionally flushing the impregnated seeds, beans, nuts, cereals and pseudo-cereals of step c) with subcritical or supercritical COin order to remove traces of impregnation fluid;'}e) depressurising the impregnation chamber; andf) retrieving ready-to-use seeds, beans, nuts, cereals and pseudo-cereals containing the desired additives.2. The method of wherein the solvents of step b) claim 1 , if present claim 1 , are selected from the group consisting of ethanol claim 1 , water or propylene glycol claim 1 , triacetin claim 1 , vegetable oil and medium chain triglyceride (MCT) oil.3. The method of wherein claim 1 , in step c) claim 1 , the impregnation fluid is injected into the impregnation chamber under supercritical conditions at a temperature of at least 31° C. and a pressure of at least 72.8 bars.4. The method of wherein claim 1 , in step c) claim 1 , the contacting time ranges between 15 minutes and 5 hours.5. The method of wherein claim 1 , in step e) claim 1 , the impregnation chamber is depressurised at a rate ranging between 1 and 60 seconds per bar.6. The method of wherein in step e) the carbon dioxide evaporated during depressurisation is recycled.7. The method of ...

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24-03-2022 дата публикации

ORAL DELIVERY SYSTEMS BASED ON IN SITU FORMING PROTEIN/POLYSACCHARIDE COACERVATES

Номер: US20220087941A1
Автор: Caillard Romain
Принадлежит:

An oral delivery system based on in situ forming protein/polysaccharide coacervates is described herein. The system comprises an active ingredient dispersed in a dry, homogenous powder mixture of a protein powder and a polysaccharide powder, which is able to form a protein/polysaccharides complex coacervate in situ upon immersion in gastric fluid, thereby conferring gastric protection and/or modified-release to the active ingredient. Varying the ratio of protein powder to polysaccharide powder in the oral delivery system varies the level of gastric protection and/or rate of release to the active ingredient. The ability of the system described herein to be based on natural and/or naturally-derived biopolymers provides commercial advantages in terms of regulatory approval and/or growing consumer demand for such products. 1. An oral delivery system comprising or consisting essentially of a dry homogenous mixture comprising a protein powder and a polysaccharide powder mixture , and an active ingredient dispersed therein , the protein and polysaccharide powder mixture forming a protein/polysaccharide complex coacervate in situ upon immersion of the oral delivery system in a gastric fluid , thereby conferring gastric protection and/or modified release to the active ingredient , wherein varying the ratio of protein powder to polysaccharide powder in the oral delivery system varies the level of gastric protection and/or rate of release of the active ingredient , and wherein the polysaccharide powder has , or is conditioned to have , one or more of the following powder flow characteristics:(a) an angle of repose (α) greater than 28 degrees;(b) a dynamic cohesive index greater than 10;(c) a compressibility index (Carr index) greater than 15%;(d) a Hausner ratio greater than 1.18; or(e) any combination of (a) to (d).2. The oral delivery system of claim 1 , wherein the polysaccharide powder has claim 1 , or is conditioned to have claim 1 , one or more of the following powder ...

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15-03-2018 дата публикации

MICROENCAPSULATES CONTAINING STABILISED LIPID, AND METHODS FOR THE PRODUCTION THEREOF

Номер: US20180071224A1
Автор: Bleiel Sinead
Принадлежит:

The invention provides a gelated mono-nuclear microencapsulate comprising a lipid emulsion core encapsulated within a gastro-resistant, ileal sensitive, polymerized chitosan membrane shell, wherein the lipid emulsion core comprises denatured or hydrolysed protein and carbohydrate. In one embodiment of the invention, the emulsion is a micro-emulsion, and typically comprises a surfactant and a co-surfactant or at least two carbohydrates, for example sucrose and a maltodextrin. In one embodiment of the invention, the lipid is a marine derived lipid such as fish oil, krill oil, or nutraceutical fatty acids. In other embodiment, the lipid is a fatty acid such as DHA or ARA, or a lipid derived from seeds, nuts or eggs. 1. A gelated mono-nuclear microencapsulate comprising a lipid microemulsion core encapsulated within a gastro-resistant , ileal sensitive , polymerized chitosan membrane shell , wherein the lipid emulsion core comprises denatured or hydrolysed protein and carbohydrate.2. A gelated mono-nuclear microencapsulate as claimed in in which the microemulsion is a SMEDDS microemulsion.3. A gelated mono-nuclear microencapsulate as claimed in in which the lipid is selected from a marine-derived lipid claim 1 , a lipid derived from nuts claim 1 , seeds claim 1 , egg claim 1 , a fatty acid or a triglyceride.4. A gelated mono-nuclear microencapsulate as claimed in in which the lipid is a marine derived oil selected from fish oil claim 1 , hill oil claim 1 , or algal oil.5. A gelated mono-nuclear microencapsulate as claimed in in which the lipid is a fatty acid selected from Docosahexaenoic acid (DHA) or Arachidonic acid (ARA).6. A gelated mono-nuclear microencapsulate as claimed in in which the lipid microemulsion comprises a surfactant and optionally a co-surfactant.7. A gelated mono-nuclear microencapsulate as claimed in in which the carbohydrate is a polysaccharide.8. A gelated mono-nuclear microencapsulate as claimed in in which the carbohydrate is a glucose- ...

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15-03-2018 дата публикации

POLYPEPTIDE AND IMMUNE MODULATION

Номер: US20180072778A1
Принадлежит:

The present invention relates to flagellin, and/or a polynucleotide sequence encoding said flagellin, and/or a vector comprising said polynucleotide sequence, and/or a host cell, including bacteria, comprising said vector, and/or a host cell, including bacteria, comprising said polynucleotide sequence, for use in modulating the inflammation of a tissue or an organ in a subject. 1RoseburiaRoseburia. flagellin , and/or a polynucleotide sequence encoding said flagellin , and/or a vector comprising said polynucleotide sequence , and/or a host cell , including bacteria comprising said vector , and/or a host cell , including bacteria , comprising said polynucleotide sequence , for use in modulating the inflammation of a tissue or an organ in a subject.230.-. (canceled)31RoseburiaRoseburia. A pharmaceutical composition comprising flagellin claim 1 , and/or a polynucleotide sequence encoding said flagellin claim 1 , and/or a vector comprising said polynucleotide sequence claim 1 , and/or a host cell claim 1 , including bacteria claim 1 , comprising said vector claim 1 , and/or a host cell claim 1 , including bacteria claim 1 , comprising said polynucleotide sequence of claim 1 , and a pharmaceutically acceptable excipient claim 1 , carrier or diluent.3236.-. (canceled)37RoseburiaRoseburia. A process for producing a nutritional supplement according to claim 31 , said process comprising admixing said flagellin claim 31 , and/or said polynucleotide sequence claim 31 , and/or said vector claim 31 , and/or said host cell claim 31 , including bacteria claim 31 , comprising said vector claim 31 , and/or said host cell claim 31 , including bacteria claim 31 , comprising said polynucleotide sequence claim 31 , with a pharmaceutically acceptable excipient claim 31 , carrier or diluent; optionally said flagellin claim 31 , and/or said polynucleotide sequence claim 31 , and/or said vector claim 31 , and/or said host cell claim 31 , including bacteria claim 31 , comprising said vector ...

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15-03-2018 дата публикации

GELLING ESTERIFIED CELLULOSE ETHERS

Номер: US20180072820A1
Принадлежит:

An esterified cellulose comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.03 to 0.38, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 20° C. 1. An esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH , R being a divalent hydrocarbon group , whereini) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4,ii) the total degree of ester substitution is from 0.03 to 0.38, andiii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 20° C.2. The esterified cellulose ether of wherein the total degree of ester substitution is from 0.09 to 0.27.3. The esterified cellulose ether of having a degree of substitution of aliphatic monovalent acyl groups of from 0.03 to 0.20 and a degree of substitution of groups of formula —C(O)—R—COOH of from 0.01 to 0.15.4. The esterified cellulose ether of having a weight average molecular weight Mof up to 100 claim 1 ,000 Dalton.5. The esterified cellulose ether of wherein the aliphatic monovalent acyl groups are acetyl claim 1 , propionyl or butyryl groups claim 1 , and the groups of the formula —C(O)—R—COOH are —C(O)—CH—CH—COOH.6. The esterified cellulose ether of wherein at least 85 wt. % of the esterified cellulose ether is soluble in a mixture of 2.5 weight parts of the esterified cellulose ether and 97.5 weight parts of water at 2° C.7. An aqueous composition comprising an esterified cellulose ether of dissolved in an aqueous liquid.8. The aqueous composition of comprising at least 10 weight percent of the esterified cellulose ether claim 7 , based on the total weight of the aqueous composition.9. A liquid composition comprising at least ...

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18-03-2021 дата публикации

A METHOD INDUCING SATIETY IN A MAMMAL

Номер: US20210077386A1
Принадлежит:

A therapeutic or non-therapeutic method of inducing satiety in a mammal is described. The method comprises administering to the mammal a composition comprising microparticles, in which the microparticles comprise lipid contained within a gastric-resistant, ileal-sensitive, carrier configured for release of the lipid in the ileum, wherein the composition is administered 1-3 hours prior to a meal. The carrier is a protein, typically denatured or hydrolysed plant or dairy protein, that is polymerised to form a lipid containing shell or matrix. 1. A non-therapeutic method of inducing satiety in a healthy mammal , the method comprising administering to the mammal a composition comprising microparticles , in which the microparticles comprise lipid contained within a gastric-resistant , ileal-sensitive , carrier configured for release of the lipid in the ileum , wherein the composition is administered 1-3 hours prior to a meal , and in which the carrier comprises a polymerised plant or dairy protein membrane.2. A method according to claim 1 , in which the plant or dairy protein is denatured or hydrolysed plant or dairy protein.3. A method according to claim 1 , in which the composition comprises 100-400 Kcal of lipid claim 1 , in which the lipid is contained within the microparticles.4. A method according to claim 1 , in which the microparticles have a core-shell morphology in which the carrier is a polymerised plant or dairy protein membrane shell surrounding a lipid core.5. A method according to claim 4 , in which the lipid core consists essentially of lipid.6. A method according to claim 4 , in which:the plant or dairy protein is denatured or hydrolysed plant or dairy protein; andin which the lipid core consists essentially of lipid.7. A method according to claim 1 , in which:the plant or dairy protein is denatured or hydrolysed plant or dairy protein; andthe composition comprises 100-400 Kcal of lipid, in which the lipid is contained within the microparticles.8. A ...

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14-03-2019 дата публикации

Stabilized fat soluble nutrient compositions and process for the preparation thereof

Номер: US20190075831A1
Принадлежит: OmniActive Health Technologies Ltd

A stabilized composition of fat soluble nutrient(s) includes a water soluble polymer and at least one nutraceutically acceptable excipient. The composition can be in the form of significantly amorphous aqueous microparticulate mixtures or as a solid beadlet product. A process for preparation of a stabilized composition includes a fat soluble nutrient solubilized in an organic solvent embedded in an aqueous polymer phase by evaporation, so as to obtain an aqueous microparticulate mixture. This mixture is stable, soluble and can be formulated for end use or can be layered on inert core for example to obtain stable beadlet(s) for use in solid dosage forms. Such stabilized aqueous microparticulate and solid beadlet compositions exhibit good solubility and dispersibility. Stabilized compositions of fat soluble nutrients can be prepared using industrially convenient equipment and can be formulated as per requirement for use in health applications.

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14-03-2019 дата публикации

COMPOSITIONS COMPRISING NANOPARTICLES DERIVED FROM WHOLE FRUIT AND/OR WHOLE VEGETABLES

Номер: US20190075832A1
Автор: UNDERWOOD Robert Lee
Принадлежит:

Nanoparticles may be derived from whole fruit and whole vegetables to form various compositions. The compositions may have a total anthocyanin concentration ranging from about 60 mg to about 2000 mg per 100 g of nanoparticles. The nanoparticles may have a particles size less than about 1000 nanometers. The compositions may be used in nutraceutical products, dietary supplements, added to food or drinks, topical agents, and combinations thereof. 1. A composition comprising nanoparticles derived from one or more whole fruits and/or one or more whole vegetables , wherein the nanoparticles have a particle size less than about 1000 nanometers , and wherein the composition comprises a total anthocyanin concentration ranging from about 0.06 mg to about 2 mg per 1 g of nanoparticles.2. The composition of claim 1 , wherein the one or more whole fruits is selected from the group consisting of cherries claim 1 , blueberries claim 1 , pomegranates claim 1 , raspberries claim 1 , plums claim 1 , cranberries claim 1 , black chokeberries claim 1 , black elderberries claim 1 , eggplant claim 1 , grapes claim 1 , peaches claim 1 , mangoes claim 1 , bananas claim 1 , apples claim 1 , kiwis claim 1 , gooseberries claim 1 , watermelon claim 1 , jujubes claim 1 , cantaloupes claim 1 , apricots claim 1 , nectarines claim 1 , mulberries claim 1 , figs claim 1 , jackfruit claim 1 , pears claim 1 , carambola starfruit claim 1 , plantains claim 1 , sapodillas claim 1 , passionfruit claim 1 , quinces claim 1 , melons claim 1 , pineapple claim 1 , guava claim 1 , dates claim 1 , tamarinds claim 1 , Saskatoon berries claim 1 , loganberries claim 1 , dewberries claim 1 , sea buckthorns claim 1 , persimmon claim 1 , coconuts claim 1 , lychees claim 1 , citrus fruits claim 1 , and combinations thereof.3. The composition of claim 1 , wherein the one or more whole vegetables is selected from the group consisting of avocados claim 1 , collard greens claim 1 , asparagus claim 1 , lettuce claim 1 , ...

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31-03-2022 дата публикации

MICROENCAPSULATION WITH POTATO PROTEINS

Номер: US20220095659A1
Принадлежит: International Flavors & Fragrances Inc.

An emulsion and encapsulation particle containing an active material and an unhydrolyzed potato protein, as an emulsifier, are provided as is a method of producing the encapsulation particle. 1. An emulsion comprising:(a) a plurality of oil droplets each containing an active material; and(b) a first emulsifier that is an unhydrolyzed potato protein,wherein the emulsion has a pH of 1 to 5, the plurality of oil droplets is dispersed in a continuous phase, and the oil droplets and unhydrolyzed potato protein are present in the emulsion at a ratio in the range of 10:1 to 1:10.2. The emulsion of claim 1 , wherein each of the plurality of oil droplets has a diameter of 0.1 μm to 20 μm.3. The emulsion of or claim 1 , wherein the oil droplets are present in an amount of 0.1% to 60% by weight of the emulsion.4. The emulsion of any one of the preceding claims claim 1 , wherein the unhydrolyzed potato protein is present in an amount of 0.1% to 60% by weight of the emulsion.5. The emulsion of any one of the preceding claims claim 1 , further comprising a second emulsifier.6. The emulsion of any one of the preceding claims claim 1 , wherein the emulsion has a pH of 3 to 4.7. The emulsion of any one of the preceding claims claim 1 , wherein and the oil droplets and unhydrolyzed potato protein are present in the emulsion at a ratio in the range of 2:1 to 1:2.8. The emulsion of any one of the preceding claims claim 1 , further comprising an antioxidant.9. The emulsion of any one of the preceding claims claim 1 , wherein the active material is selected from the group consisting of a fragrance claim 1 , pro-fragrance claim 1 , flavor claim 1 , malodor counteractive agent claim 1 , vitamin or derivative thereof claim 1 , anti-inflammatory agent claim 1 , fungicide claim 1 , anesthetic claim 1 , analgesic claim 1 , antimicrobial active claim 1 , anti-viral agent claim 1 , anti-infectious agent claim 1 , anti-acne agent claim 1 , skin lightening agent claim 1 , insect repellant claim 1 ...

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12-03-2020 дата публикации

Gellan seamless breakable capsule and process for manufacturing thereof

Номер: US20200078274A1
Принадлежит: V Mane Fils SAS

The invention relates to a process for manufacturing a seamless breakable capsule, comprising —co-extruding an external and hydrophilic liquid phase, and an internal and lipophilic liquid phase, in order to form a capsule constituted of a core comprising the internal and lipophilic phase, and a shell comprising the external and hydrophilic phase, —immersing into an aqueous solution containing a curing agent, wherein the external liquid phase includes a gelling agent comprising gellan gum alone or in combination with another gelling agent, a filler, and a divalent metal sequestering agent, and to breakable capsules comprising a core and a shell, wherein the shell includes a gelling agent comprising gellan gum alone or in combination with another gelling agent, a filler, and a divalent metal sequestering agent.

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25-03-2021 дата публикации

GUM ARABIC/CHITOSAN COACERVATE SYSTEM

Номер: US20210084953A1
Принадлежит:

Described herein is the method of using a complex coacervate system including Gum Arabic and chitosan as lubricating agents. Also described herein are consumer products including the complex coacervate system. 1. A method of using a complex coacervate system , the method comprising using the complex coacervate system as a lubricating agent in a consumer product , said complex coacervate system comprising a first biopolymer and a second biopolymer , wherein the first biopolymer is Gum Arabic and wherein the second biopolymer is chitosan.2. The method according to claim 1 , wherein the complex coacervate system is a complex coacervate droplets slurry comprising at least one complex coacervate droplet made of the first biopolymer and the second biopolymer.3. The method according to claim 1 , wherein the complex coacervate system is a complex coacervate microcapsules slurry comprising at least one microcapsule having an oil-based core comprising a hydrophobic active ingredient and a coacervate shell made of the first biopolymer and the second biopolymer.4. The method according to claim 2 , wherein the complex coacervate droplets slurry is obtainable by a process comprising the step of mixing a first and second biopolymer in an aqueous vehicle under conditions sufficient to form a suspension of complex coacervate droplets claim 2 , wherein this step is performed under acidic conditions.5. The method according to claim 3 , wherein the complex coacervate microcapsule slurry is obtainable by a process comprising the steps of:(i) mixing a first and second biopolymer in an aqueous vehicle under conditions sufficient to form a suspension of complex coacervate droplets, wherein this step is performed under acidic conditions, and(ii) adding a hydrophobic core material to the complex coacervate droplets to form core/shell capsules each containing the core material encapsulated by a coacervate shell made of chitosan and Gum Arabic.6. The method according to claim 1 , wherein the ...

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12-03-2020 дата публикации

EDIBLE ALCOHOL-CONTAINING SPHERES

Номер: US20200080036A1
Принадлежит: CDJ Partners, LLC

A shelf stable, edible sphere containing alcohol and methods for preparing the same. The edible sphere comprises a liquid and/or gel inner core comprising ethyl alcohol and an outer membrane comprising alginate, wherein the outer membrane coats and encapsulates the liquid and/or gel inner core and wherein the edible sphere is shelf stable for at least one month. The process for preparing the shelf stable, edible sphere comprises combining an alcoholic beverage, a calcium salt, and optionally one or more further components to form a cocktail solution, de-aerating and either freezing the cocktail solution to form a frozen cocktail solution or adding a thickening compound to the de-aerated cocktail solution to form a viscous cocktail solution, immersing the frozen cocktail solution or viscous cocktail solution in a sodium alginate bath at ambient temperature for a period of time to form an edible sphere containing alcohol, and removing the edible sphere containing alcohol from the alginate bath and rinsing it with water to form a shelf stable edible sphere. 1. A shelf stable , edible sphere comprising (1) a liquid and/or gel inner core comprising ethyl alcohol and (2) an outer membrane comprising alginate , wherein the outer membrane coats and encapsulates the liquid and/or gel inner core and wherein the shelf stable , edible sphere is shelf stable for at least one month.2. The shelf stable claim 1 , edible sphere of claim 1 , wherein the ethyl alcohol is derived from an alcoholic beverage.3. The shelf stable claim 2 , edible sphere of claim 2 , wherein the alcoholic beverage is derived from a distilled spirit and/or a liqueur.4. The shelf stable claim 3 , edible sphere of claim 3 , wherein the distilled spirit is selected from the group consisting of grain alcohol claim 3 , vodka claim 3 , gin claim 3 , rum claim 3 , tequila claim 3 , whiskey/whisky claim 3 , brandy claim 3 , cachaça claim 3 , metaxa claim 3 , mezcal claim 3 , ouzo claim 3 , absinthe claim 3 , and any ...

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29-03-2018 дата публикации

ENCAPSULATION SYSTEM FOR PROTECTION OF PROBIOTICS DURING PROCESSING

Номер: US20180084805A1
Принадлежит:

Comestible products, for example beverage products, are disclosed containing encapsulated probiotic bacteria having resistance to subjection to at least thermal and acidic conditions. Beverage products include at least one aqueous liquid and capsules comprising a gelled mixture of alginate and denatured protein, and probiotic bacteria entrapped within the gelled mixture. The average particle size of the capsules is optionally less than 1000 microns (μm) in diameter, such as less than 500 μm in diameter. Methods are provided for making such encapsulated probiotics by providing a mixture comprising sodium alginate, denatured protein and active probiotic cells, and combining the mixture with a divalent cation to initiate cold gelation of the sodium alginate and denatured protein to form a second mixture. The second mixture is passed through an opening having a diameter of less than 1000 μm to form capsules. The weight ratio of protein to alginate is from 1:1 to 9:1. 1. A food product comprising:{'sup': 9', '12, 'a plurality of capsules comprising a gelled mixture of substantially chemically unreacted alginate selected from a group consisting of sodium alginate or potassium alginate; denatured whey protein isolate; and about 1.0×10-1.0×10CFU/gram of probiotic bacteria cells;'}wherein the weight ratio of whey protein isolate to alginate is between 1:1 to 9:1;wherein the capsules have an average particle size of between about 1 micron to about 1000 microns (μm) in diameter; andwherein each of the plurality of capsules has an outer shell and an interior material comprising the same biopolymers, and wherein the outer shell has a denser polymerization than the interior material2. The food product of claim 1 , wherein the food product is a beverage claim 1 , and wherein the beverage further comprises:at least one aqueous liquid; andbetween 0.1 grams and 3 grams of the plurality of capsules per fluid ounce of beverage.3. The beverage of claim 2 , wherein the weight ratio of ...

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05-05-2022 дата публикации

Agglomerated Flavor Composition

Номер: US20220132876A1
Принадлежит:

Disclosed herein are compositions comprising agglomerates formed of fruit flakes and target ingredients, such as flavorings, colorings, aromatic particles, nutrients, etc. Also disclosed are methods for making fruit flake agglomerates that can deliver higher concentrations of flavorings, colorings, aromatic particles, nutrients, etc.

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01-04-2021 дата публикации

CLEAN LABEL BAKING POWDER

Номер: US20210092963A1
Принадлежит:

In certain example embodiments, the invention comprises an agent for leavening baked goods comprising sodium bicarbonate and dried buffered vinegar. In some embodiments, the sodium bicarbonate is encapsulated in a lipid material, such as palm oil, fractionated palm oil, fully hydrogenated palm oil, mono- and di-glycerides, fully hydrogenated cottonseed oil, or fully hydrogenated soybean oil. In another aspect, the invention provides a method of making an agent for leavening baked goods comprising mixing together sodium bicarbonate, dried buffered vinegar, and a lipid material, such as described herein. 1. An agent for leavening baked goods comprising sodium bicarbonate and dried buffered vinegar.2. The agent of claim 1 , wherein the dried buffered vinegar has a neutralization value of 35 to 40 claim 1 , optionally wherein the dried buffered vinegar has a neutralization value of 37.5.3. (canceled)4. The agent of claim 1 , wherein the dried buffered vinegar comprises acetic acid claim 1 , citric acid claim 1 , malic acid claim 1 , lactic acid claim 1 , or a combination thereof; preferably wherein the dried buffered vinegar comprises acetic acid.5. (canceled)6. The agent of claim 1 , wherein the sodium bicarbonate is encapsulated in a lipid material.7. The agent of claim 6 , wherein the lipid material is palm oil.8. The agent of claim 7 , wherein the palm oil is fractionated palm oil and preferably has a melting range of 55-60° C.9. (canceled)10. The agent of claim 7 , wherein the palm oil is fully hydrogenated palm oil and preferably has a melting range of 58-63° C.11. (canceled)12. The agent of claim 6 , wherein the lipid material comprises mono- and di-glycerides claim 6 , and preferably wherein the mono- and di-glycerides have a melting range of 58-63° C.13. (canceled)14. The agent of claim 6 , wherein the lipid material is fully hydrogenated cottonseed oil claim 6 , and preferably wherein the fully hydrogenated cottonseed oil has a melting range of 61-65° C.15. ( ...

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