16-05-2013 дата публикации
Номер: US20130123781A1
This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment. 1. A targeting microbubble comprising:(a) a core containing a fluid having a normal boiling point less than about 30° C.;(b) an anchoring moiety comprising a bio-lipid, protein, surfactant, or synthetic polymer; and (i) a chemical group having an affinity for a metal-containing material; or', '(ii) a cell specific ligand., '(c) a targeting moiety comprising2. The targeting microbubble of claim 1 , wherein the anchoring moiety and the targeting moiety are linked via a covalent claim 1 , ionic claim 1 , or hydrogen-bonding linkage.3. The targeting microbubbles of claim 2 , wherein the anchoring moiety covalently attached to the targeting moiety.4. The targeting microbubble of claim 1 , further comprising a polymeric linker that covalently attaches the anchoring moiety to the targeting moiety.5. The targeting microbubble of claim 1 , wherein the fluid is air claim 1 , CO claim 1 , a fluorinated or perfluorinated Chydrocarbon claim 1 , or a combination thereof.6. The targeting microbubble of claim 5 , wherein the fluorinated hydrocarbon is perfluoropropane or perfluoropentane.7. The targeting microbubble of claim 5 , wherein the targeting moiety comprises a chemical group having an affinity for a metal-containing material.8. The targeting microbubble of claim 1 , wherein the chemical group comprises a chelant having at least two amino claim 1 , carboxy claim 1 , hydroxyl claim 1 , phosphoryl claim 1 , or thiol groups claim 1 , or a combination thereof claim 1 , said chelant having an affinity for the metal-containing material.9. The targeting microbubble of ...
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