Verfahren und Vorrichtung zum Ausdrücken von Körperflüssigkeiten aus einem Einstich

Vorrichtung zum Ausdrücken von Körperflüssigkeiten aus einer angestochenen Hautfläche beinhaltend ein Gehäuse und ein Haut-Einstechmedium sowie einen Haut-Stechmechanismus zum Anwenden des Haut-Einstechmediums, um in einer Haut einen Einstich zu bilden und das Haut-Einstechmedium aus dem Einstich der Haut wieder zu entfernen sowie ein an einem Ende des Gehäuses angebrachtes Stimulatorelement wobei das Stimulatorelement dafür ausgelegt ist, um an einem angestochenen Abschnitt einer Hautoberfläche eines Benutzers herum an diesem anzugreifen, so dass das Strömen von Körperflüssigkeit gefördert wird, dadurch gekennzeichnet, dass das Stimulatorelement eine Schraubenfeder aufweist und die Schraubenfeder zum Gehäuse hin zusammendrückbar ist, wenn die Haut eines Benutzers gegen das Stimulationselement gedrückt wird.

Methods and apparatus for expressing body fluid from an incision

Patches for reverse iontophoresis

SELECTIVE EXPOSITION OF MINIATURE PROBES WITH INTEGRATED SENSOR ARRAYS FOR CONTINUOUS IN-VIVO DIAGNOSIS

BODY FLUID WITHDRAWAL DEVICE

DEVICE TO THE BODY FLUID WITHDRAWAL AND - ANALYSIS

DEVICE AND PROCEDURE FOR THE DETERMINATION OF THE CONCENTRATION OF ANALYTEN

EQUIPMENT FOR THE MEASUREMENT OF THE BLOOD CLOTTING AND ITS PROCEDURES

TEST DEVICE FOR BODY FLUIDS

PROCEDURE AND EQUIPMENT FOR THE SAMPLING AND ANALYSIS OF INTERSTITIAL LIQUID AND FULL BLOOD

EQUIPMENT TO THE WITHDRAWAL OF INTERSTITIAL LIQUID FOR DIAGNOSTIC ONE TEST

METHODS AND DEVICES FOR DETECTION AND ACQUISITION OF BIOMARKERS

The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

Non-invasive biomedical detection and monitoring systems

The present disclosure relates to a non-invasive and continuous biomedical detections and non-invasive and continuous monitoring methods and devices for extracting and analyzing interstitial fluid extracted non-invasively and continuously from the skin of a subject comprising non-invasively electroporating the skin using a non pulsed voltage in combination with a pulsed voltage and applying negative pressure ...

Methods and devices for detection and acquisition of biomarkers

The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

Liquid collection device

A pen format liquid collection device includes an elongate generally tubular housing (12, 112, 212, 312) able to be held by hand and having an opening at one end, and at least one liquid take-up element (30, 130, 230, 330) mounted in the housing so as to be positioned or positionable to project at the opening, the at least one liquid take-up element then further postionable by hand manipulation of the housing to contact a volume of liquid to thereby take- up a sample of the liquid to be analysed. At least one retention element (230a, 330a) is supported in the housing. The at least one liquid take-up element and the at least one retention element are arranged whereby they are relatively movable into contact, and the at least one retention element is adapted on contact to in turn take-up the sample and retain the sample or a component thereof for in situ analysis or later recovery while protected within the housing. The liquid take-up element is preferably a capillary.

DELIVERING AND/OR RECEIVING FLUIDS

The present application generally relates to receiving bodily fluid through a device opening. The device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator.

Device for measuring blood coagulation and method thereof

Body fluid sampling device and methods of use

APPARATUS FOR MICROPORATION OF BIOLOGICAL MEMBRANES USING THIN FILM TISSUE INTERFACE DEVICES, AND METHOD THEREFOR

The invention provides for improved devices and methods for forming openings in a biological membrane for delivering substances into an animal through the biological membrane for treatment applications, or extracting substances from the animal through the biological membrane for monitoring or other diagnosis applications and for increased transmembrane flux.

DEVICES FOR PHYSIOLOGICAL FLUID SAMPLING AND METHODS OF USING THE SAME

Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable firm the silt, where the order of the above-described steps may be altered. The subject devices include at least one silo flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.c., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sifts in the fingers, arms, legs, earlobes, heels, feet, nose: and toes. Also provided ...

A MICRONEEDLE AND A CHIP

A microneedle and a chip are disclosed for extraction of fluids. The microneedle (101) provided on a substrate (102), comprises an elongated body (503) extending from a distal end (504) with a bevel (505) to a proximal end (506) on the substrate along a longitudinal axis; the elongated body comprises a capillary bore (507) extending in a longitudinal direction thereof and defines a fluid path (508); the proximal end is integrally connected with the substrate and the capillary bore is in fluid communication with a fluid channel (309) of the substrate. The cross-sectional area of the capillary bore in the distal end is larger than the cross-sectional area of the capillary bore in the proximal end.

MICRO-INVASIVE METHOD FOR PAINLESS DETECTION OF ANALYTES IN EXTRACELLULAR SPACE

A method of detecting at least one analyte in extra-cellular spaces includes the step of inserting a microprobe through the stratum corneum toward the stratum basale of the skin of a subject into extra-cellular spaces containing interstitial fluid having at least one analyte to be detected, said microprobe having a diameter at its tip no larger than approximately 10-50 microns. The method further includes optically testing for a predetermined analyte in the extra-cellular space adjacent the distal end of the microprobe without drawing a sample of the interstitial fluid. Preferably the microprobe body includes a sensor layer covering the distal optical tip of the microprobe body, the sensor layer being adapted to interact with a predetermined analyte to be detected in the interstitial fluid, and an optical detector responsive to interaction of the sensor layer with the predetermined analyte to signal detection of said predetermined analyte.

NON-INVASIVE BIOMEDICAL DETECTION AND MONITORING SYSTEMS

SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION

Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.

NON-INVASIVE BIOMEDICAL DETECTION AND MONITORING SYSTEMS

The present disclosure relates to a non-inva-sive and continuous biomedical detections and non-inva-sive and continuous monitoring methods and devices for extracting and analyzing interstitial fluid extracted non-in-vasively and continuously from the skin of a subject com-prising non-invasively electroporating the skin using a non pulsed voltage in combination with a pulsed voltage and applying negative pressure ...

DEVICE AND METHOD FOR ENHANCING TRANSDERMAL AGENT FLUX

An agent delivery or sampling device (2) comprising a member (6) having a plurality of blades (4) for piercing the skin and a connecting medium (65) covering at least a part of the skin contacting side (48) of the member (6) for increasing transdermal flux of an agent.

PENETRATION OF ANESTHETIC AGENTS FOR LOCAL IMPACT OF, EXERCISED BY MEANS OF LASER

ПРОНИКНОВЕНИЕ АНЕСТЕЗИРУЮЩИХ СРЕДСТВ ДЛЯ МЕСТНОГО ВОЗДЕЙСТВИЯ, ОСУЩЕСТВЛЯЕМОЕ С ПОМОЩЬЮ ЛАЗЕРА

... 1. Способ введения терапевтически эффективного количества фармацевтической композиции с использованием лазера, включающий изменение проницаемости кожи с помощью лазерного луча, имеющего плотность энергии, достаточную для облучения кожи на глубину рогового слоя без достижения капиллярного слоя для создания места альтерации с диаметром от 0,5 мкм до 5,0 см; и нанесение терапевтически эффективного количества фармацевтической композиции в месте альтерации. 2. Способ по п.1, в котором лазер выбирают из группы, состоящей из лазера Er:YAG, импульсных СO2 -лазеров, лазеров Ho:YAG, Er:YAP, Er/Cr:YSGC, Ho:YSGC, Er:GGSG, Er:YLF, Tm:YAG, Ho:YAG; Ho/Nd:YALOs, кобальт:МgF2 , химического на HF, химического на DF, на монооксиде углерода, лазеров дальнего УФ-диапазона и лазера Nd:YAG с утроением частоты. 3. Способ по п.1, в котором лазер представляет собой лазер Er:YAG. 4. Способ по п.1, в котором лазер представляет собой модулируемый лазер, выбираемый из группы, состоящей из лазеров с непрерывным излучением ...

Dialysis combination and microdialysis probe and insertion means intendent for said combination

Improved micro-needles and methods of manufacture and use thereof

A micro-needle is provided which is particularly useful for the minimally invasive sampling of a biological fluid and/or the minimally invasive delivery of a drug or other formulation across the skin. The micro-needle has a structure having a base at a proximal end and a vertex at a distal end, and an open lumen extending there through and through which fluid may be transferred. The structure defines a structural axis that intersects the lumenal axis defined by the open lumen. The point of intersection between these axes is at a point below the vertex of the micro-needle to provide a sharp apex at the distal end of the micro-needle and defines the general configuration of the distal end of the micro-needle, which may be selected or customized depending on the intended use of the microneedle. The micro-needle may be integral with a measurement device for measuring the concentration of a constituent within sampled biological fluid and/or with a fluid reservoir for containing a fluid to be ...

ULTRASONICALLY ACTUATED NEEDLE PUMP SYSTEM

An ultrasonically driven pump, which may be used for sampling body fluids or atomizing liquids, has a stationary outer needle and an inner needle mounted within the bore of the outer needle. The distal end of the inner needle is positioned adjacent to the distal end of the outer needle. The inner needle is ultrasonically vibrated by an ultrasonic actuator without vibrating the outer needle, with resulting draw of liquid through the distal end of the outer needle into the bore of the inner needle for discharge through the proximal end of the inner needle. The outer needle can be formed to have a penetrating tip suited for penetrating the skin of a subject to allow sampling of body fluids including interstitial fluids. The pump can also be used for atomizing liquid, by drawing liquid from a supply that is pumped from the distal end to an open proximal end of the inner needle where the liquid is discharged by automization into the atmosphere.

METHOD AND DEVICE FOR SAMPLING AND ANALYZING INTERSTITIAL FLUID AND WHOLE BLOOD SAMPLES

The invention disclosed in this application is a method and device (10) for combining the sampling and analyzing of sub-dermal fluid samples, e.g., interstitial fluid or whole blood, in a device suitable for hospital bedside and home use. The device includes a dermal layer penetration probe (12) in fluid communication with an analysis chamber (20). It is applicable to any analyte that exists in a usefully representative concentration in the fluid, and is especially suited to the monitoring of glucose.

Removable tip for laser device with safety interlock

An applicator for use with a laser device housing comprises an applicator body mountable for moving in the housing when at least a minimum amount of pressure is applied to the applicator by contact with a patient's skin to actuate a mechanism in the housing for operation of the laser device, and an applicator distal end affixed to the body and positionable substantially in a focal plane of the laser device by motion of the body upon application of at least the minimum amount of pressure. The mechanism may be an interlock, or a switch, or a switch for charging capacitors of the laser device. The Interlock may be a spring-mounted interlock.

Sampling device of suction effusion fluid

A sampling device of the suction effusion fluid that is good in sampling operation efficiency. This device includes a cell with a vacuum suction port and a skin suction port, a slide valve formed in the cell, and fluid reservoirs formed in the valve. The slide valve is movable in a plane approximately parallel to the skin surface. The slide valve opens or closes a communication path communicating the skin suction port with the vacuum suction port. Each of the fluid reservoirs is alternately communicated with the skin suction port and the vacuum suction port through the communication path by sliding movement of the slide valve. Each of the fluid reservoirs stores an effusion fluid acquired from the skin surface by vacuum suction through the skin suction port. When the slide valve is located at a position where one of the fluid reservoirs is communicated with the skin suction port and the vacuum suction port, at least one of the remaining fluid reservoirs is exposed to the outside of the ...

Harvesting cell-free non-coding RNAS (CFNCRS) from interstitial fluid for sensitive biomarkers

A system for determining the presence of cell-free non-coding RNA (cfNCR) biomarkers in interstitial fluid includes a microfluidic device for non-invasively and passively accessing interstitial fluid from a patient. The microfluidic device is formed of a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.

Blood and interstitial fluid sampling device

A device and method for lancing a patient, virtually simultaneously producing and collecting a small fluid sample from a body. The device comprises a blood collection system including a lancing needle, drive mechanism, kneading or vibration mechanism, optional suction system, and sample ejection mechanism. The device is preferably sized to be hand-held in one hand and operable with one hand. The device can optionally contain integral testing or analysis component for receiving the sample and providing testing or analysis indication or readout for the user. A method involves piercing the skin at a rapid rate, kneading the surrounding area by ultrasonic action, piezoelectric or mechanical oscillation to stimulate the blood flow from the wound, drawing the fluid using a pumping system.

SYSTEM AND METHOD FOR CONTINUOUS ANALYTE MONITORING

DEVICE FOR ENHANCING TRANSDERMAL AGENT FLUX

A device (3) comprising a sheet number (6) having a plurality of microprotrusions (4) for penetrating the skin and a rigid support (15) contacting and extending across the sheet member (6) for transmitting an applied force evenly across the length and width of the sheet member (6) to reproducibly and reliably penetrate the skin with the microprotrusions (4).

Apparatus for sampling body fluid

Body fluid is sampled by causing a syringe (26) mounted in a housing (12) to be displaced towards a skin surface. The syringe (26) remains in the resulting incision while the surrounding body tissue is stimulated by a stimulator ring (70) to urge body fluid towards the incision. Simultaneously, the syringe (26) is moved relative to the incision to keep the incision open.

METHOD AND APPARATUS FOR ENHANCING FLUX RATES OF FLUID IN MICROPORATED BIOLOGICAL TISSUE

PROBLEM TO BE SOLVED: To provide a method and apparatus for enhancing the transportation rate of a substance through biological membrane. SOLUTION: The invention is a method for enhancing the flux rate of a substance through a microporated tissue 5. The method includes a step to deliver an effective amount of flux enhancer 42 to the tissue through at least one micropore 30 in the tissue. In one embodiment, the step to deliver the flux enhancer 42 includes that a probe 40 with an effective amount of the flux enhancer 42 is inserted into the tissue. In another embodiment, the step to deliver the flux enhancer includes that a quantity of the flux enhancer 42 is placed around the microporated tissue and at least a part of a quantity of the flux enhancer 42 is discharged to the tissue through at least one micropore. COPYRIGHT: (C)2007,JPO&INPIT ...

УСТРОЙСТВА ДЛЯ ОТБОРА ПРОБ ФИЗИОЛОГИЧЕСКИХ ЖИДКОСТЕЙ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ ТАКИХ УСТРОЙСТВ

... 1. Устройство для определения пригодного места для отбора пробы физиологической жидкости, содержащее по меньшей мере один элемент для определения течения в указанном месте, и по меньшей мере один элемент для прокалывания кожи, предназначенный для доступа к физиологической жидкости в указанном месте. 2. Устройство по п.1, отличающееся тем, что указанный по меньшей мере один элемент для определения течения содержит элемент, выполненный с возможностью определения температуры в указанном месте. 3. Устройство по п.1, отличающееся тем, что по меньшей мере один элемент для определения течения содержит элемент, выполненный с возможностью определения эритроцитов в указанном месте. 4. Устройство по п.1, отличающееся тем, что по меньшей мере один элемент для определения течения содержит по меньшей мере один источник света для освещения ткани светом, и по меньшей мере один детектор для детектирования света, поглощенного тканью. 5. Устройство по п.4, отличающееся тем, что по меньшей мере один источник ...

Устройство дл определени концентрации анализируемого вещества и способы их применени

... 1. Индикаторная полоска для определения концентрации, по меньшей мере, одного анализируемого вещества в физиологической пробе, содержащая множество прикрепленных к ней игл для прокалывания кожи, при этом индикаторная полоска выполнена с возможностью приема в измеритель. 2. Индикаторная полоска по п.1, в которой множество элементов для прокалывания кожи расположено по существу перпендикулярно индикаторной полоске. 3. Индикаторная полоска по п.1, в которой множество элементов для прокалывания кожи расположено по существу параллельно индикаторной полоске. 4. Индикаторная полоска по п.1, которая дополнительно содержит два электрода, разделенные прокладочным слоем, при этом, по меньшей мере, один электрод сопряжен с инертным материалом подложки. 5. Индикаторная полоска по п.4, в которой множество элементов для прокалывания кожи прикреплено к инертному материалу подложки. 6. Индикаторная полоска по п.4, в которой множество элементов для прокалывания кожи образовано указанным инертным материалом ...

Устройство для получения образца

INTERSTITIAL LIQUID WITHDRAWAL AND MEASUREMENT OF THE COMPONENTS

INTERSTITIAL LIQUID WITHDRAWAL

DEVICE FOR THE INCREASE OF THE LIQUID FLOW VELOCITY IN A BIOLOGICAL FABRIC WITH MICROPORES

DEVICE TO THE SAMPLING OF BODY FLUID

PROCEDURE AND DEVICE FOR THE CONTINUOUS MONITORING OF A ANALYTEN

INTEGRATED PORATIONS, COLLECTING AND ANALYSIS DEVICE AND PROCEDURE FOR IT

TRANSDERMALE TRANSPORT DEVICE FOR CONTROLLED REMOVING FROM BIOLOGICAL DIAPHRAGMS BY PYROTECHNIC LOAD

DEVICE FOR THE IMPROVEMENT THE TRANSDERMALEN OF THE RIVER OF MEDICINES

NEEDLE FOR BODY FLUID TESTERS

SYSTEM TO THE WITHDRAWAL OF BODY FLUIDS

MICRON ARISTOCRACY MECHANISMS AND PROCEDURES FOR THE THEIR PRODUCTION

INTEGRATED LANZETTE AND TESTSTREIFEN FOR ANALYTIC MEASUREMENT

DEVICES TO THE WITHDRAWAL OF BODY FLUIDS

DEVICE TO MIKROPORATION A BIOLOGICAL FABRIC OF MEANS A FILM FABRIC INTERFACE DEVICE AND PROCEDURE

SECOND MEDICAL INDICATION OF A PARTICLE ADMINISTRATION METHOD

Interstitial fluid collection and constituent measurement

Method and kit for assisting diagnosis of disease in subject

The present invention addresses the problem of providing a method for assisting the evaluation of the health condition of a subject, wherein fluctuation of the sampling amount of a disease marker, said fluctuation being caused by a change in the skin barrier function of the subject, is corrected and thus data that accurately reflects the health condition of the subject is acquired. To solve this problem, provided is a method for assisting the diagnosis of a disease in a subject using a disease marker and a reference marker, said method comprising: employing annexin A2 as the reference marker; applying to the subject's skin surface a sheet capable of generating an attractive force due to the electrostatic interaction between the disease marker and the reference marker; stripping off the sheet from the skin surface; measuring the sticking amounts of the disease marker and the reference marker to the sheet; and then acquiring data relating to the disease in the subject on the basis of the ...

Disposable element for use in a body fluid sampling device

Needle for body fluid tester

Liquid collection device

A pen format liquid collection device includes an elongate generally tubular housing (12, 112, 212, 312) able to be held by hand and having an opening at one end, and at least one liquid take-up element (30, 130, 230, 330) 5 mounted in the housing so as to be positioned or positionable to project at the opening, the at least one liquid take-up element then further positionable by hand manipulation of the housing to contact a volume of liquid to thereby take up a sample of the liquid to be analysed. At least one retention element (230a, 330a) is supported in the housing. The at least one liquid take-up element and 0 the at least one retention element are arranged whereby they are relatively movable into contact, and the at least one retention element is adapted on contact to in turn take-up the sample and retain the sample or a component thereof for in situ analysis or later recovery while protected within the housing. The liquid take-up element is preferably a capillary.

NEEDLE FOR BODY FLUID TESTER

... ▓▓▓An apparatus for collecting a body fluid for testing for an analyte includes a ▓needle (510) for penetrating a patient's skin to access the fluid within the ▓skin. The needle has a hollow body (514) extending from a first end (600) to a ▓second end (601). An interior surface of the body defines a fluid pathway ▓(512) extending between the ends. The second end is positioned to deposit ▓fluid for testing. The first end has a beveled face (520) on a front side of ▓the body. The beveled face terminates at a penetration tip (530) with the ▓beveled face having an opening in communication with the fluid pathway. The ▓penetration tip is burnished to a rounded shape and bent to facilitate low ▓pain and rapid fluid collection.▓ ...

DEVICES FOR ANALYTE CONCENTRATION DETERMINATION AND METHODS OF USING THE SAME

Test strips and methods are provided for use in the determination of the concentration of at least one target analyze in a physiological sample. The subject test strips include a plurality of skin-piercing elements affixed thereto. In the subject methods, the plurality of skin-piercing elements affixed to the test strip is inserted into the skin, physiological sample is transferred to the test strip and the concentration of an analyte is determined. The subject test strips and methods find use in a variety of different applications, particularly in the determination of glucose concentrations.

METHOD FOR EXTRACTING INTERSTITIAL FLUID

A method for extracting interstitial fluid from a target site of a user includes adhesively attaching a floating ring of a sampling module for extracting interstitial fluid to the user in the vicinity of a target site and then mounting the sampling module to the floating ring and attaching the sampling module to the user. Subsequently, the target site is penetrated with a penetration member of the sampling module. Pressure is then applied in another vicinity of the target site by a pressure ring of the sampling module and, thereafter, ISF extracted from the target site via a penetration member of the sampling module.

FLUID COLLECTION DEVICE

Disclosed embodiments relate to a collection device for bodily fluids comprising a tubular material with a first end and second end. A portion of the first end is configured to be secured to a user and the tubular material may be folded over itself to form a first sheath and a second sheath. In some applications, the fluid collection devices described may be secured to a user using interlocking loops.

A MICRONEEDLE AND A CHIP

A microneedle and a chip are disclosed for extraction of fluids. The microneedle (101) provided on a substrate (102), comprises an elongated body (503) extending from a distal end (504) with a bevel (505) to a proximal end (506) on the substrate along a longitudinal axis; the elongated body comprises a capillary bore (507) extending in a longitudinal direction thereof and defines a fluid path (508); the proximal end is integrally connected with the substrate and the capillary bore is in fluid communication with a fluid channel (309) of the substrate. The cross-sectional area of the capillary bore in the distal end is larger than the cross-sectional area of the capillary bore in the proximal end.

APPARATUS FOR OBTAINING BIOLOGICAL FLUIDS

This invention provides a method and apparatus for disrupting the outermost layer of the skin, the stratum corneum, to provide access to biological fluid, which can be used to determine the concentration of glucose in blood. The invention can be used to extract interstitial fluid, blood and mixtures of interstitial fluid and blood from the body of a human or an animal. The method comprises the steps of 1) attaching a receptacle (26) for collecting biological fluid to the surface of the skin of a patient, 2) introducing an oscillation concentrator (20) attached to an oscillation element (12) into the receptacle (26), 3) positioning the oscillation concentrator (20) at a desired distance from the surface of the skin, 4) activating the oscillation element (12) to transversely oscillate the attached oscillation concentrator (20), 5) collecting the biological fluid after a specific period of time, and 6) analyzing the biological fluid for the presence of an analyte.

LASER ASSISTED TOPICAL ANESTHETIC PERMEATION

The present invention provides an improved method of administering a pharmaceutical composition, such as an anesthetic through the skin of a patient without the use of a sharp or needle. This method includes the step of irradiating the stratum corneum of a region of the skin of the patient using a laser. By a selection of parameters, the laser irradiates the surface of the skin precisely to a selectable depth, without causing clinically relevant damage to healthy proximal tissue. A pharmaceutical composition is then applied to the region of irradiation.

DEVICE FOR ENHANCING TRANSDERMAL AGENT FLUX

A device (3) comprising a sheet number (6) having a plurality of microprotrusions (4) for penetrating the skin and a rigid support (15) contacting and extending across the sheet member (6) for transmitting a n applied force evenly across the length and width of the sheet member (6) to reproducibly and reliably penetrate the skin with the microprotrusions (4).

PROCESS TO DETECT WEAVEEED CANCEROUS

VIBRATING NEEDLE ADJUSTMENT DEVICE

A vibrating needle adjustment device in accordance with an embodiment of the present application includes a housing mountable at any desired position on a needle and a vibrating element in the housing to vibrate the needle about multiple axes.

A TRANSFER DEVICE FOR TRANSFERRING A SUBSTANCE BETWEEN THE DEVICE AND A SUBJECT

A micro-needle delivery device (1) comprises an active substance accommodating layer (17) having active substance accommodating chambers (20) therein, a drive substance accommodating layer (32) having drive substance accommodating chambers (35) therein aligned with the active substance accommodating chambers (20), an activating layer (45) having heating elements (48) aligned with the drive substance accommodating chambers (35) for heating a drive substance therein, and a micro-needle element (8) having a needle support layer (9) and a plurality of micro-needles (12) extending therefrom. A burstable first membrane (22) is located between and sealably secured to the micro-needle element (8) and to the active substance accommodating layer (17) for sealably closing the active substance accommodating chambers (20) at one end. A second stretchable membrane (30) is located between and sealably secured to the drive substance accommodating layer (32) and to the active substance accommodating layer ...

MEDICAL DEVICES AND KITS INCLUDING SAME

A medical device is described, comprising an array (10) comprising microstructures (12) configured to penetrate the stratum corneum upon impact, and a connection member (20) affixed to the array in a one piece construction, the connection member configured to reversibly connect the medical device to an applicator. The medical devices of the invention may be used in methods requiring the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue through the skin. In use, it is generally desirable to provide the microstructures at a height sufficient to penetrate the stratum corneum. A medical kit is also described, comprising the foregoing medical device and a tray (34) configured to hold the medical device.

METHOD OF DETECTING CANCEROUS LESIONS

A method for measuring the periodicity of changes in blood perfusion over large regions of skin so as to identify a locally impaired neuronal control, thereby providing a quick and inexpensive screening test for relatively shallow neoplastic lesions, such as breast cancer, is described. The present method is predicated on infrared imaging of the skin to detect changes in the spectral structure and spatial distribution of thermoregulatory frequencies (TRFs) over different areas of the skin.

IMPROVED INTERSTITIAL FLUID MONITORING

The present invention provides an improved method of measuring analytes in body fluids without the use of a sharp. The method having the steps of irradiating the skin of a patient by focused pulses of electromagnetic energy emitted by a laser. By proper selection of wavelength, energy fluence, pulse temporal width and irradiation spot size, the pulses precisely irradiate the skin to a selectable depth, without causing clinically relevant damage to healthy portions of the skin. After irradiation, interstitial fluid is collected into a container or left on the skin. The interstitial fluid is then tested for a desired analyte to approximate the analyte concentration in other body fluids. Alternatively, after the forced formation of a microblister, the epidermis covering the microblister is lysed and the interstitial fluid is subsequently collected and tested.

Method of detection of cancerous lesions by their effect on the spatial distribution of modulation of temperature and homogeneity of tissue

A method for measuring the periodicity of changes in blood perfusion over large regions of skin so as to identify a locally impaired neuronal control, thereby providing a quick and inexpensive screening test for relatively shallow neoplastic lesions, such as breast cancer, is described. The present method is predicated on infrared imaging of the skin to detect changes in the spectral structure and spatial distribution of thermoregulatory frequencies (TRFs) over different areas of the skin.

Devices for physiological fluid sampling and methods of using the same

Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable from the site, where the order of the above-described steps may be altered. The subject devices include at least one site flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.e., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sites in the fingers, arms, legs, earlobes, heels, feet, nose and toes. Also provided ...

ELECTRICALLY FUNCTIONAL POLYMER MICRONEEDLE ARRAY

A sensor device, such as a biosensor, may comprise a polymer substrate, which is structured so as to form sets of microneedles and respective vias. The microneedles extend, each, from a base surface of the substrate. Each of the vias extends through a thickness of the substrate, thereby forming a corresponding set of apertures on the base surface. Each of the apertures is adjacent to a respective one of the microneedles. The device further may comprise two or more electrodes, these including a sensing electrode and a reference electrode. Each electrode may comprise an electrically conductive material layer that coats a region of the substrate, so as to coat at least some of the microneedles and neighboring portions of said base surface. Related devices, apparatuses, and methods of fabrication and use of such devices may be provided.

Enhanced interstitial fluid collection

A sampling apparatus for interstitial fluid includes a pressure ring surrounding a collection needle. The pressure ring and needle are movable relative to one another for the ring to first engage a patient's skin surface prior to insertion of the needle.

Laser assisted pharmaceutical delivery and fluid removal

The present invention provides improved devices for pharmaceutical delivery and fluid removal using laser ablation or alteration. These devices have marking means for marking the ablation or alteration site, the area around the site, or the site and the area around the site. In a preferred embodiment, the mark created by the devices is a physical mark which remains detectable after the marking means is inactivated or redirected away from the site.

ELECTRICALLY FUNCTIONAL POLYMER MICRONEEDLE ARRAY

A sensor device, such as a biosensor, may comprise a polymer substrate, which is structured so as to form sets of microneedles and respective vias. The microneedles extend, each, from a base surface of the substrate. Each of the vias extends through a thickness of the substrate, thereby forming a corresponding set of apertures on the base surface. Each of the apertures is adjacent to a respective one of the microneedles. The device further may comprise two or more electrodes, these including a sensing electrode and a reference electrode. Each electrode may comprise an electrically conductive material layer that coats a region of the substrate, so as to coat at least some of the microneedles and neighboring portions of said base surface. Related devices, apparatuses, and methods of fabrication and use of such devices may be provided.

Device and method for enhancing transdermal flux of agents being sampled

A transdermal agent sampling device is provided. The sampling device is comprised of a microblade array and a device for applying a partial vacuum. The microblade array comprises a sheet having a plurality of microblades for piercing the skin to a very shallow depth (i.e., 25 mum to 400 mum) to create microslits in the outermost stratum corneum layer of the skin. The partial vacuum applying device applies a partial vacuum in the range of about 0.1 to about 0.8 atm, and preferably about 0.3 to about 0.7 atm, for sampling a body analyte such as glucose in interstitial fluid. The partial vacuum is applied for a period of about 2 to about 30 seconds, and preferably about 5 to about 15 seconds. The interstial fluid is analyzed for body analyte (e.g., glucose) content or concentration.

WEARABLE, CONTINUOUS BIOLOGICAL FLUID MONITORING SYSTEM

Methods, systems, and apparatus, including biological fluid monitoring systems comprising a microneedle layer; at least one electromagnet assembly; and at least two liquid chambers coupled via a microfluidic layer, wherein the microneedle layer comprises a plurality of microneedles configured to extract interstitial fluid (ISF) from a patient in to one of the at least two liquid chambers, and wherein the at least one electromagnet assembly is configured to a move a test sample of the extracted ISF through the at least two liquid chambers to conduct a test cycle.

SUBSTANCE SAMPLING AND/OR SUBSTANCE DELIVERY VIA SKIN

Interstitial fluid collection method and interstitial fluid collection kit and interstitial fluid collection sheet used for the method

A interstitial fluid collection kit for collecting interstitial fluid extracted via micropores formed in a skin is disclosed. The kit includes a marker sheet (2) that has an adhesive face and that defines a region in which micropores are to be formed; a transparent retention sheet (11) having an adhesive face; and a collecting body (12) that is retained by a part of the adhesive face of the retention sheet (11) and that collects interstitial fluid extracted from the skin.

METHOD AND DEVICE FOR SAMPLING AND ANALYZING INTERSTITIAL FLUID AND WHOLE BLOOD SAMPLES

The invention disclosed in this application is a method and device (10) for combining the sampling and analyzing of sub-dermal fluid samples, e.g., interstitial fluid or whole blood, in a device suitable for hospital bedside and home use. The device includes a dermal layer penetration probe (12) in fluid communication with an analysis chamber (20). It is applicable to any analyte that exists in a usefully representative concentration in the fluid, and is especially suited to the monitoring of glucose.

ОФТАЛЬМОЛОГИЧЕСКАЯ ЛИНЗА С МИКРОЖИДКОСТНОЙ АНАЛИТИЧЕСКОЙ СИСТЕМОЙ

Группа изобретений относится к медицине. Офтальмологическое устройство имеет систему анализа глазной жидкости и содержит многоэлементную кольцевую несущую вставку, содержащую передний элемент вставки и задний элемент вставки, соединённые и вместе герметизированные; источник энергии, герметизированный внутри несущей вставки; микрожидкостную аналитическую систему, герметизированную внутри несущей вставки и находящуюся в электрическом соединении с источником энергии, причем микрожидкостная аналитическая система при функционировании выполнена с возможностью измерения одного или более свойств пробы глазной жидкости; процессор, образующий часть упомянутой несущей вставки и выполненный с возможностью выполнения программы, включающей в себя предварительно запрограммированные пороговые значения для одного или более свойств глазной жидкости, и вывода сигнала, когда результаты измерений находятся за пределами соответствующих предварительно запрограммированных пороговых значений; и искусственную пору ...

Probenentnahmevorrichtung für Körperflüssigkeit

Vorrichtung zum Ausdrücken von Körperflüssigkeit aus einem in der Hautoberfläche gebildeten Einschnitt, die aufweist: ein Gehäuse mit einem Ende; ein Einweglanzettenelement, das im Gehäuse angeordnet ist; und ein Stimulatorelement mit einem ersten Ende, das im Gehäuse angeordnet ist, und einem zweiten Ende, das angepasst ist, um über das Ende des Gehäuses hinaus zu ragen, wobei das Stimulatorelement in Längsrichtung relativ zum Gehäuse verschiebbar ist.

NADEL FÜR KÖRPERFLÜSSIGKEITSTESTSATZ

GERÄT ZUR ENTNAHME VON INTERSTITIELLEN FLÜSSIGKEIT FÜR DIAGNOSTISCHE TESTE

Apparatus for analysis of perspiration or interstitial fluid in diagnosis has sampling unit connected to channel which can be evacuated, ring of adhesive surrounding sampler and sensor being mounted inside channel

Apparatus for analysis of skin fluids has a sampling unit (5) connected to a channel (6) which can be evacuated. A ring of adhesive (8) on its underside surrounds the sampler. A sensor (2) is mounted inside the channel.

Microneedle device for removal of bodily fluid

A microneedle device 1 comprising at least one hollow microneedle 60 defining a tip 61, a base end 62 and an internal bore 65 connecting an opening 64 in the microneedle to the base end 62 of the microneedle. Wherein, a microporous material 67 is provided in said internal bore 65, the microporous material 67 defining an internal flow path for fluid to pass through the porous material. In another aspect, the devices incorporate microneedles 4 capable of fluidly linking the body to a high capacity absorbent material 3 capable of absorbing at least 5 times its own weight of said fluid. In other aspects, the microneedles may be hollow hydro gel microneedles, solid microporous microneedles, hydrophobic hollow microneedles provided with bores having a hydrophilic lining.

Body fluid sampling device and methods of use

A device for sampling body fluid includes a housing (12) having a sleeve (102) at a forward end thereof which is displaceable in response to being pressed against a user's skin to trigger the firing of a lancet (150). After the lancet (150) is removed from the incision, the sleeve (102) is repeatedly pressed against the skin to depress a ring of body tissue in surrounding relationship to the incision to express body fluid outwardly through the incision. A pusher member (24) is then actuated to push a capillary tube (164) through a front end of the housing for drawing in body fluid. The lancet (150) is a disposable lancet which includes a body supporting a skin lancing member (154) and the capillary tube (164). The disposable lancet (150) passes through an upper end of a lancet carrier (16) when being installed or removed. The device cannot be armed until the disposable lancet (150) is installed in the housing (12), because the capillary tube (164) functions to push a safety device to a ...

Device and method for characterisation of biological samples

An apparatus for characterizing an analyte in a sample volume of the surface layer of the skin of a patient comprises a radiation source located outside the body and configured to irradiate the sample 12. A reflector 4 implanted beneath the surface layer of the skin 10 defines the sample volume and is configured to receive incident radiation that has passed through the sample and reflect it back through the sample to a sensor located outside the body. A mask prevents radiation from the source bypassing the reflector to damage other tissue. The analyte may be glucose. The features of the radiation measured by the sensor may be raman scattered radiation. Growth factors may be applied to the skin to promote capillary growth in the sample volume.

Method of using and electrochemical device

Glucose Monitoring System

A body fluid sampling system for use on a tissue site includes a drive force generator and one or more microneedles operatively coupled to the drive force generator. Each of a microneedle has a height of 500 to 2000 μm and a variable tapering angle of 60 to 90°. A sample chamber is coupled to the one or more microneedles. A body fluid is created when the one or more microneedles pierces a tissue site flows to the sample chamber for glucose detection and analysis.

Transdermal systems, devices, and methods for biological analysis

A transdermal test sensor includes a test chamber including a liquid, a reagent system in contact with the liquid, a housing containing the liquid, and a semipermeable membrane. The housing includes an opening, the semipermeable membrane is connected to the housing and covers the opening, and the housing and the semipermeable membrane enclose the liquid and the reagent system. The transdermal test sensor also includes an analyzer in communication with the liquid. When porated tissue is contacted with the semipermeable membrane and sufficient time is allowed for a fluid sample to traverse the porated tissue and for an analyte in the fluid sample to enter the liquid in the transdermal sensor through the semipermeable membrane, a change in at least one optical property or at least one electrical property of the liquid is detected. The change detected is then correlated with the analyte concentration in the fluid sample.

Systems and methods for collecting fluid from a subject

Systems and methods for delivering to and/or receiving fluids or other materials, such as blood or interstitial fluid, from subjects, e.g., from the skin. Beading disruptors and/or capillaries may be used for facilitating the transport of fluids from a subject into a device. Beading disruptors may disrupt the “pooling” of bodily fluids such as blood on the surface of the skin and help influence flow in a desired way. A capillary may conduct flow of fluid in the device, e.g., to an inlet of a channel or other flow path that leads to a storage chamber. A vacuum (reduced pressure relative to ambient) may be used to receive fluid into the device, e.g., by using relatively low pressure to draw fluid into the inlet of a channel leading to a storage chamber. The vacuum source may be part of the device.

Body fluid testing device

Body fluid testing device for analyzing a body fluid comprises a test media tape adapted to collect the body fluid. The test media tape comprises a tape and test media portions. A free tape portion without test medium is located between successive test media portions. The testing device further comprises a supply portion. The supply portion comprises a housing in which uncontaminated test media tape is contained. The housing further has an opening for withdrawing test media tape from the housing. The testing device further has a sealing means for closing the opening against the surrounding. A free tape portion of the test media tape is located between a wall of the housing and the sealing means when the sealing means closes the opening. Further aspects concern a test media cassette with sealing means and a method for providing test media while holding them sealed against humidity during onboard storage.

Delivering and/or receiving fluids

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

Disposable hand-held device for collection of exhaled breath condensate

A breath condensate collection apparatus comprising a central chamber, a breath input assembly, a plunger assembly and a breath condensate collection port. The central chamber has inner and outer side walls with a coolant material sealed in between. The breath input assembly is disposed on the side of the central chamber in fluid communication with the chamber interior. The plunger assembly has a piston, slidably disposed in the chamber, and a handle extending from a first end of the chamber. The collection port is disposed at the second end of the central chamber in fluid communication with the interior of the chamber. Obstructive structures may be arranged in the chamber interior for increasing the surface area on which condensate may form. The apparatus may also include an outlet assembly that may be removed and replaced with a sampling well into which the condensate may be washed with a buffer solution.

Biological information monitoring apparatus

A biological information monitoring apparatus includes: a measurer which is configured to measure biological information of a subject; a display on which a measurement value of the biological information measured by the measurer is displayed; a calibration controller which, when a predetermined condition is satisfied, is configured to perform a calibration process on the measurer; a time measurer which is configured to acquire a remaining time before the calibration process is ended; and a display controller which is configured to cause an index indicating the remaining time to be displayed on the display.

METHOD FOR QUANTITATIVE MEASUREMENT OF GASTRIC ACIDITY USING 13C CARBONATE SALT

The present invention provides a method for measuring the gastric acidity of a mammal using a C-labeled carbonate compound. Specifically, the present invention relates to a method for measuring the gastric acidity of a mammal including the following steps: 1. A method for measuring an effect of a gastric acid reducer on a mammal , the method comprising the following steps (1) to (4):{'b': '1', 'sup': 13', '13, 'sub': '2', '() using, as a test sample, expired air of a mammalian subject excreted at any point in time within 30 minutes after oral administration of a predetermined amount of a C-labeled carbonate compound, the oral administration being performed after administration of a gastric acid reducer, measuring behavior of COexcreted in the expired air,'}{'sup': 13', '13', '13', '13', '13, 'sub': 2', '2', '2', '2, '(2) comparing the behavior of CO(measured CObehavior) obtained in step (1) with the behavior of corresponding CO(reference CObehavior) measured in a mammal (control mammal) to which a predetermined amount of a C-labeled carbonate compound has been orally administered beforehand without administering the gastric acid reducer;'}{'sup': 13', '13, 'sub': 2', '2, '(3) determining gastric acidity of the mammalian subject based on a difference between the reference CObehavior and the measured CObehavior obtained above; and'}(4) determining the effect of the gastric acid reducer on the mammalian subject using the gastric acidity of the mammalian subject obtained above as an index.2. The method according to claim 1 , wherein the behavior of COis ΔC (‰) obtained from expired air of a mammalian subject collected at any point in time within 30 minutes after oral administration of a C-labeled carbonate compound.3. The method according to claim 1 , wherein the predetermined amount is 10 mg to 5 g.4. The method according to claim 1 , wherein the C—labeled carbonate compound is at least one carbonate compound selected from the group consisting of alkali metal ...

SYSTEM AND METHOD OF MONITORING RESPIRATORY PARAMETERS

A spirometer includes a housing, a mouthpiece coupled to the housing, and a measurement unit. The measurement unit is configured to receive air expelled by a user, and generate an electrical quantity corresponding to a peak expiratory flow or a forced expiratory volume based on the expelled air. The spirometer also includes a processing module supported by the housing, and configured to receive the electrical quantity from the measurement unit, a display coupled to the measurement unit to display an indication of the peak expiratory flow or the forced expiratory volume, and an energy harvester. The energy harvester is coupled to the measurement unit and the processing module, and is configured to receive energy from one of a group consisting of the measurement unit and an energy sensor, store the received energy in an energy storage device, and transfer the energy to the processing module. 1. A spirometer comprising:a housing;a mouthpiece coupled to the housing;a measurement unit configured to receive air expelled by a user, and generate an electrical quantity corresponding to a peak expiratory flow or a forced expiratory volume based on the expelled air;a processing module supported by the housing, and configured to receive the electrical quantity from the measurement unit; and receive energy from one of a group consisting of the measurement unit and an energy device,', 'store the received energy in an energy storage device, and', 'transfer the energy to the processing module., 'an energy harvester coupled to the measurement unit and the processing module, the energy harvester configured to'}2. The spirometer of claim 1 , wherein the housing includes a set of guiderails along a length of the housing claim 1 , and wherein the mouthpiece is movable relative to the housing between a first position in which the mouthpiece is recessed within the housing claim 1 , and a second position in which the mouthpiece is exposed outside the housing.3. The spirometer of claim 2 , ...

Intelligent Health Monitoring Toilet System with Wand Sensors

The health monitoring toilet system includes an extendable, retractable, and rotatable wand with sensors on the head section. The sensors may include a variety of cameras and gas sensors for inspecting a user's urogenital, perineal, and anal region for health assessment. The wand may comprise a bidet wand. The bidet wand may also dispense cleansing and therapeutic substances. The toilet system may include a controller which may store the sensor readings as well as protocols for moving the wand to acquire optimal sensor readings. The controller may be accessible by a healthcare provider for diagnostic and treatment purposes. The toilet system may identify each user to store sensor reading acquired for different users in the controller. 1. A health monitoring toilet system comprising:a. a wand, wherein the wand is extendible, retractable, and rotatable;b. one or more sensor, wherein the one or more sensor is disposed on the wand, and wherein the one or more sensor comprises an infrared sensor configured to measure one or more of the following temperatures: a body temperature of the user, a localized temperature on a user's anatomy, a temperature of the user's waste; and a temperature of the water in the toilet bowl;c. a controller, wherein the controller receives and processes data from the one or more sensor;d. a non-transitory computer readable medium, wherein the non-transitory computer readable medium is in connection with the controller through an electronic connection, and wherein the non-transitory computer readable medium stores data associated with a user.2. The health monitoring toilet system of claim 1 , wherein the one or more sensor comprises at least one camera.3. The health monitoring toilet system of claim 2 , wherein the at least one camera comprises an infra-red camera.4. The health monitoring toilet system of claim 1 , wherein the one or more sensor comprises a digital imaging device.5. The health monitoring toilet system of claim 1 , wherein the ...

INFORMATION PROVISION METHOD, INFORMATION PROCESSING SYSTEM, INFORMATION TERMINAL, AND INFORMATION PROCESSING METHOD

In order to objectively grasp a stress state of a user and to prevent postpartum depression, biological gas information is acquired via a network, where the biological gas information indicates a concentration of ethylene glycol of the user and is obtained by a sensor that detects ethylene glycol released from a skin surface of the user. From a memory storing information including an upper limit of a normal range of the concentration of ethylene glycol per unit period, the information indicating the upper limit of the normal range is read out. When a frequency in the unit period with which the concentration of ethylene glycol of the user exceeds the upper limit of the normal range is determined to have an increasing tendency based on the biological gas information obtained during a pregnancy period of the user, the information related to stress of the user is output to an information terminal of the user. 1. A method for providing information in an information processing system , the method comprising:acquiring, via a network, biological gas information representing a concentration of ethylene glycol of a user detected with a sensor for detecting ethylene glycol released from a skin surface of the user;obtaining reference information representing an upper limit of a normal range of the concentration of ethylene glycol per unit period of time, using a memory storing the reference information representing the upper limit of the normal range; andoutputting information related to stress of the user to an information terminal after it is determined that a frequency with which the concentration of the ethylene glycol of the user per unit period of time is more than the upper limit of the normal range tends to increase, based on the biological gas information acquired in a pregnancy period of the user.2. The method according to claim 1 , whereinthe information including the upper limit of the normal range of the concentration of ethylene glycol per the unit period is set ...

INFORMATION PROVISION METHOD, INFORMATION PROCESSING SYSTEM, INFORMATION TERMINAL, AND INFORMATION PROCESSING METHOD

To objectively grasp a stress state of a user and to prevent a mental disorder of the user, the following steps are performed: acquiring, via a network, biogas information at multiple timings and time information corresponding to each of the multiple timings, wherein the biogas information represents a concentration of phenol of a user acquired by a sensor that detects phenol discharged from a skin surface of the user; obtaining reference information representing an upper limit of a normal range of the concentration of phenol per unit period of time, using a memory storing the reference information representing the upper limit of the normal range; determining a stress time period during which a concentration of the phenol of the user is more than the upper limit of the normal range, based on the acquired biological gas information; and outputting time period information indicating the determined stress time period to an information terminal of the user, to display the stress time period indicated by the time period information on a display of the information terminal. 1. A method for providing information in an information processing system , the method comprising:acquiring, via a network, biogas information at multiple timings and time information corresponding to each of the multiple timings, wherein the biogas information represents a concentration of phenol of a user acquired by a sensor that detects phenol discharged from a skin surface of the user;obtaining reference information representing an upper limit of a normal range of the concentration of phenol per unit period of time, using a memory storing the reference information representing the upper limit of the normal range;determining a stress time period during which a concentration of the phenol of the user is more than the upper limit of the normal range, based on the acquired biogas information; andoutputting time period information indicating the determined stress time period to an information terminal ...

Information provision method, information processing system, information terminal, and information processing method

In order to objectively grasp a stress state of a user and to prevent postpartum depression, biological gas information is acquired via a network, where the biological gas information indicates a concentration of phenol of the user and is obtained by a sensor that detects phenol released from a skin surface of the user. From a memory storing information including an upper limit of a normal range of the concentration of phenol per unit period, the information indicating the upper limit of the normal range is read out. When a frequency in the unit period with which the concentration of phenol of the user exceeds the upper limit of the normal range is determined to have an increasing tendency based on the biological gas information obtained during a pregnancy period of the user, the information related to stress of the user is output to an information terminal of the user.

INFORMATION PROVIDING METHOD, INFORMATION PROCESSING SYSTEM, INFORMATION TERMINAL, AND INFORMATION PROCESSING METHOD

A method comprising: acquiring via a network biogas information representing a concentration of 2-ethylhexanoic acid of the user acquired by a sensor that detects the 2-ethylhexanoic acid discharged from a skin surface of the user; obtaining the reference information representing a lower limit of a normal range of the concentration of 2-ethylhexanoic acid per unit period of time, using a memory storing the reference information; and outputting information related to stress of the user an information terminal of the user, after it is determined that a frequency that concentration of the 2-ethylhexanoic acid of the user per the unit period of time is less than the lower limit of the normal range tends to increase, based on the biogas information acquired in a pregnancy period of the user. 1. A method for providing information in an information processing system , the method comprising:acquiring, via a network, biogas information representing a concentration of 2-ethylhexanoic acid of a user acquired by a sensor that detects the 2-ethylhexanoic acid discharged from a skin surface of the user;obtaining reference information representing a lower limit of a normal range of the concentration of 2-ethylhexanoic acid per unit period of time, using a memory storing the reference information representing the lower limit of the normal range; andoutputting information related to stress of the user to an information terminal after it is determined that a frequency with which the concentration of the 2-ethylhexanoic acid of the user per unit period of time is less than the lower limit of the normal range tends to increase, based on the biogas information acquired in a pregnancy period of the user.2. The method according to claim 1 , whereinthe lower limit of the normal range of the concentration of 2-ethylhexanoic acid per unit period of time is set for the user as individual information of the user, based on the biogas information acquired in a predetermined period of time in an ...

MICRONEEDLE AND CHIP

A microneedle and a chip are disclosed for extraction fluids. The microneedle is provided on a substrate and comprises an elongated body extending from a distal end with a bevel to a proximal end on the substrate along a longitudinal axis. The elongated body comprises a capillary bore extending in a longitudinal direction thereof and defines a fluid path. The proximal end is integrally connected with the substrate and the capillary bore is in fluid communication with a fluid channel of the substrate. The cross-sectional area of the capillary bore in the distal end is larger than the cross-sectional area of the capillary bore in the proximal end. 1. A microneedle provided on a substrate , comprising: the elongated body comprises a capillary bore extending in a longitudinal direction thereof and defines a fluid path;', 'the proximal end is connected to the substrate and the capillary bore is in fluid communication with a fluid channel of the substrate;', 'wherein the cross-sectional area of the capillary bore comprises a triangular cross-section in a perpendicular direction relative the longitudinal direction of the microneedle., 'an elongated body extending from a distal end thereof with a bevel to a proximal end on the substrate along a longitudinal axis, wherein2. A microneedle according to claim 1 , wherein the triangular cross-section of the capillary bore further comprises at least one rounded corner.3. A microneedle according to claim 1 , wherein the triangular cross-section of the capillary bore comprises a convex base connected to straight sections via two rounded corners.4. A microneedle according to claim 1 , wherein the capillary bore comprises a hydrophilic surface.5. A microneedle according to claim 1 , wherein the fluid channel is configured to provide an under-pressure claim 1 , relative the atmospheric pressure claim 1 , to the capillary bore claim 1 , whereby fluid flow through the capillary bore is promoted.6. A microneedle according to claim 1 , ...

FLUID DIVERSION MECHANISM FOR BODILY-FLUID SAMPLING

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir. 139-. (canceled)40. A method of obtaining a bodily-fluid sample from a patient using a parenteral sampling device , the method comprising:establishing fluid communication between the patient and an inlet port of the parenteral sampling device;disposing a flow control mechanism in a first configuration, the first configuration operable to allow bodily-fluid to flow from the patient, through the inlet port, and into a fluid reservoir;moving an actuator a first distance to form a negative pressure in the fluid reservoir, the actuator including a seal member that defines a portion of the fluid reservoir such that the moving of the actuator the first distance moves the seal member from a first position toward a second position to form the negative pressure in the fluid reservoir;receiving a first volume of bodily-fluid into the fluid reservoir while the flow control mechanism is in the first configuration;moving the actuator a second distance, after the first volume of bodily-fluid has been received into the fluid reservoir, to move the flow control mechanism from the first configuration to a ...

Breath sampler

A breath sampler for collecting a breath sample from a patient is disclosed. The breath sampler has a non-rebreather part including a sample inlet, a one-way outlet valve downstream of the sample inlet, and an air inlet. The one-way outlet valve and the sample inlet define a first portion of an internal breath flow pathway therebetween. The air inlet is arranged to be closed by a one-way inlet valve arranged to allow air to enter the non-rebreather part. The breath sampler also has a sample delivery part in fluid communication with the non-rebreather part at an upstream end via the one-way outlet valve. The sample delivery part defines a second portion of the internal breath flow pathway, and has an air diverter, a sample outlet, a return inlet and a sample collection chamber connector. The air diverter is arranged to divide the sample delivery part into an upstream portion upstream of the air diverter and a downstream portion downstream of the air diverter and is configured to divert the breath sample into a sample collection chamber including a liquid capture interface. The sample collection chamber is coupled to the sample collection chamber connector and includes a liquid capture interface.

Apparatus and Method for Offline Collection of Breath Samples for Nitric Oxide Measurement

A breath collection and storage apparatus is disclosed for collecting and storing samples of exhaled breath for later analysis of nitric oxide contained in collected breath samples. The described apparatus provides for inhaling air into the lungs via a one-way air inflow portal through an airflow chamber via an inhalation/exhalation portal. Air inhaled into the lungs is then expelled back into the airflow chamber via the inhalation/exhalation portal and flowed into a breath storage vessel. A flow meter monitor, such as a flow meter or pressure gauge can be employed to monitor and control the rate of flow of the exhaled breath. A three-way valve can be incorporated into the air outflow portal to selectively permit discharge of exhaled breath to the outside or into the breath storage vessel. If desired, a programmable controller in electrical connection with the flow meter and three-way valve can be employed to maneuver the three-way valve to discharge and collection positions to allow for collecting and storing preselected portions of the exhaled breath. In addition, a flow rate restriction mechanism can be employed to automatically control the flow rate of exhaled air (breath) through the airflow chamber. 1. An apparatus for collecting a breath sample , comprising:(a) an exhalation portal in fluid communication with an airflow chamber;(b) an air outflow portal in fluid communication with said airflow chamber;(c) an airflow monitor in fluid communication with said airflow chamber; and(d) a detachable breath storage vessel in fluid communication with said airflow chamber via said air outflow portal.2. The apparatus of wherein said air outflow portal is a three-way valve claim 1 , said three-way valve maneuverable between an air discharge position and an air collection position.3. The apparatus of further comprising a programmable controller in electrical communication with said airflow monitor and said three-way valve claim 2 , said programmable controller configured ...

Diagnosis of tuberculosis and other diseases using exhaled breath

Disclosed are methods and devices for analyzing aerosol particles in exhaled breath using diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for capturing exhaled breath aerosols in a packed bed column and analyzing exhaled captured breath aerosols for tuberculosis diagnosis.

FLUID EXTRACTION DEVICE, APPLICATOR DEVICE AND ASSOCIATED METHODS

A device for removing fluid from a body, the device comprising an array of microneedles and a housing; the array of microneedles being disposed within the housing and the housing defining a chamber. The microneedles are moveable between a disengaged position and an engaged position where, in use in the engaged position, the microneedles penetrate the surface of a body. The chamber is adapted to surround the surface of the body through which the microneedles penetrate when in the engaged position. The chamber is configured for connection to a vacuum device such that negative pressure can be applied to the chamber. 1. A device for removing fluid from a body , the device comprising:i) an array of microneedles; andii) a housing, the array of microneedles being disposed within the housing, and the housing defining a chamber;wherein the microneedles are moveable between a disengaged position and an engaged position where, in use in the engaged position, the microneedles penetrate the surface of a body;the chamber is adapted to surround the surface of the body through which the microneedles penetrate when in the engaged position; andthe chamber is configured for connection to a vacuum device, such that negative pressure can be applied to the chamber.2. The device according to wherein the microneedle array is biased towards the disengaged position.3. The device according to wherein the device further comprises one or more resilient members which bias the microneedle array towards the disengaged position.4. The device according to wherein the microneedle array is biased towards the disengaged position after a force has been exerted on the operating means and the microneedles have moved to the engaged position.5. The device according to wherein the microneedle array is coupled to the resilient member following movement to the engaged position.6. The device according to wherein the microneedle array is coupled to the resilient member via engagement of a connector associated ...

TECHNIQUES FOR RAPID DETECTION AND QUANTITATION OF VOLATILE ORGANIC COMPOUNDS (VOCS) USING BREATH SAMPLES

An exemplary breath analysis system may include a sampling chamber having a molecule collector disposed therein. The molecule detector may be configured such that volatile organic compounds (VOCs) present in a breath sample introduced to the sampling chamber adhere to the molecule collector. A heating element may introduce heat within the sampling chamber, causing release of at least a portion of the VOCs adhered to the molecule collector. An analysis device (e.g., a mass spectrometer or tetrahertz (THz) spectrometer) may identify one or more target VOCs from among at least the portion of the VOCs released from the molecule collector and generate an output representative of the identified one or more target VOCs. The output may include information that quantitates a concentration of the one or more target VOCs with respect to a source of the breath sample. 1. A system for analyzing a breath sample , the system comprising:a sampling chamber;an inlet coupled to the sampling chamber and configured to receive a breath sample and to provide the breath sample to the sampling chamber;a molecule collector disposed within the sampling chamber, wherein the molecule collector is configured to adhere to volatile organic compounds (VOCs) present in the breath sample;a heating element configured to introduce heat within the sampling chamber; identify one or more target VOCs from among the VOCs present in the sampling chamber subsequent to release of at least a portion of the VOCs from the molecule collector, wherein at least the portion of the VOCs are released from the molecule collector by the heat introduced within the sampling chamber by the heating element; and', 'generate an output representative of the one or more target VOCs., 'an analysis device configured to2. The system of claim 1 , wherein the molecule collector comprises a Carboxen® coated mesh.3. The system of claim 1 , wherein the heating element comprises a power source coupled to the molecule collector and ...

TRANSDERMAL SAMPLING STRIP AND METHOD FOR ANALYZING TRANSDERMALLY EMITTED GASES

Transdermally emitted gasses are detected by applying a dermal sampling strip to the skin of a biological subject, capturing the gasses in a vapor space in the dermal sampling strip, and analyzing for at least one such gas captured in the vapor space of the dermal sampling strip. Analysis is preferably performed using an electrocatalytic cell, which can be mounted on the dermal sampling strip and form a wall of the vapor space. 1. A method for measuring the transdermal emission of a gas through the skin of a biological subject , comprisinga) sealably mounting at least one dermal sampling strip on the skin of the subject, wherein the dermal sampling strip includes a sample collection chamber that comprises (i) a skin contact side that is in contact with the skin when the dermal sampling strip is mounted and (ii) one or more walls, the skin contact side and the wall(s) together defining a vapor space for collecting transdermally emitted gas, wherein the skin contact side has one or more openings which create one or more fluid paths between the skin and the vapor space for collecting the transdermally emitted gas;b) collecting the transdermally emitted gas in the sample collection chamber of the dermal sampling strip(s); andc) analyzing for the presence of at least one component of the transdermally emitted gas collected in the sample collection chamber of the dermal sampling strip(s) by contacting the transdermally emitted gas with a working electrode of an electrocatalytic cell, and measuring an electrical signal created by a reaction of the at least one component of the transdermally emitted gas at the working electrode, wherein the working electrode forms or is mounted onto at least one of the walls of the sample collection chamber and further wherein the at least one component of the transdermally emitted gas is transported from the skin to the working electrode without passing through a diffusion barrier.2. The method of wherein the at least one component of the ...

Harvesting Cell-Free Non-Coding RNAS (CFNCRS) From Interstitial Fluid For Sensitive Biomarkers

A system for determining the presence of cell-free non-coding RNA (cfNCR) biomarkers in interstitial fluid includes a microfluidic device for non-invasively and passively accessing interstitial fluid from a patient. The microfluidic device is formed of a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port. 1. A system for determining the presence of cell-free non-coding RNA (cfNCR) biomarkers in interstitial fluid comprising:microfluidic sampling device for non-invasively and passively accessing interstitial fluid from a patient, the microfluidic sampling device further including at least one source of analysis fluid to be mixed with accessed interstitial fluid; andan analysis device for receiving an amount of the mixture analysis fluid and accessed interstitial fluid to determine the presence of one or more cfNCR biomarkers therein.2. The system according to claim 1 , the microfluidic sampling device comprising:a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of skin to access the interstitial fluid; andfurther wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.3. The system according to claim 2 , wherein a reservoir containing the analysis fluid is formed in or in contact with ...

DEVICE FOR CAPTURING AND CONCENTRATING VOLATILE ORGANIC COMPOUNDS

A device for capturing and concentrating volatile organic compounds (VOCs) in a sample of breath air. The device includes an intake for accepting an air sample; a disposable mouth piece; a sensor array for measuring physical parameters of the air sample; an exhaled air sampler for capturing a pre-determined volume of air; a concentrator for concentrating VOCs in the air sample; and an ionic liquid collector, the latter of which may be removed from the device. The ionic liquid collector, which may have one compartment or multiple compartments, includes at least one ionic liquid. Analysis of VOCs in the ionic liquid or liquids may identify biomarkers that can provide a medical diagnosis for a human patient based on a sample of breath air. 1. A device comprising:(a) an intake for accepting a sample of room air;(b) a disposable mouthpiece for use by a human subject, wherein the human subject breaths in the room air through the disposable mouthpiece and exhales breath back into the disposable mouthpiece;(c) a sensor array comprising one or more sensors for measuring physical parameters in the exhaled breath;(d) an exhaled air sampler for capturing a pre-determined volume of air from the exhaled breath;(e) a concentrator for receiving the pre-determined volume of air from the exhaled air sampler and concentrating VOCs in the pre-determined volume of air; and(f) an ionic liquid collector comprising at least one ionic liquid, wherein the pre-determined volume of air comprising concentrated VOCs are deposited and/or injected from the concentrator into the ionic liquid collector.2. The device of claim 1 , further comprising a volatile organic compound (VOC) filter in communication with the intake (a) and the disposable mouthpiece (b) for cleaning the room air by removing VOCs from the room air sample.3. The device of claim 2 , further comprising a fan in communication with the intake (a) and the VOC filter for moving the room air from the intake into the VOC filter.4. The ...

DELIVERING AND/OR RECEIVING FLUIDS

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication. 130-. (canceled)31. A device for receiving fluid from a subject , comprising:a housing including an opening to receive fluid into the housing;a device actuator;a vacuum chamber in the housing that is at a pressure less than ambient pressure prior to actuation of the device actuator;one or more needles being arranged to cause fluid to be released from the subject;a deployment actuator to move the one or more needles in a deployment direction toward or through the opening; anda membrane sealingly separating the opening from the vacuum chamber, the one or more needles being coupled to the membrane,wherein actuation of the device actuator actuates the deployment actuator to move the one or more needles in the deployment direction.32. The device of claim 31 , wherein the housing includes a cover and a base claim 31 , and wherein the vacuum chamber is bounded by the cover claim 31 , the base and the membrane.33. The device of claim 31 , wherein the membrane is exposed to ambient pressure below the membrane and pressure less than ambient pressure above the membrane such that the membrane is subjected to a pressure differential in a direction opposite to the deployment direction. ...

INFORMATION PROVISION METHOD, INFORMATION PROCESSING SYSTEM, INFORMATION TERMINAL, AND INFORMATION PROCESSING METHOD

In order to objectively grasp a stress state of a user and to prevent postpartum depression, biological gas information is acquired via a network, where the biological gas information indicates a concentration of 2-phenoxyethanol of the user and is obtained by a sensor that detects 2-phenoxyethanol released from a skin surface of the user. From a memory storing information including an upper limit of a normal range of the concentration of 2-phenoxyethanol per unit period, the information indicating the upper limit of the normal range is read out. When a frequency in the unit period with which the concentration of 2-phenoxyethanol of the user exceeds the upper limit of the normal range is determined to have an increasing tendency based on the biological gas information obtained during a pregnancy period of the user, the information related to stress of the user is output to an information terminal of the user. 1. A method for providing information in an information processing system , the method comprising:acquiring, via a network, biological gas information representing a concentration of 2-phenoxyethanol of a user detected with a sensor for detecting 2-phenoxyethanol released from a skin surface of the user;obtaining reference information representing an upper limit of a normal range of the concentration of 2-phenoxyethanol per unit period of time, using a memory storing the reference information representing the upper limit of the normal range; andoutputting information related to stress of the user to an information terminal after it is determined that a frequency with which the concentration of the 2-phenoxyethanol of the user per unit period of time is more than the upper limit of the normal range tends to increase, based on the biological gas information acquired in a pregnancy period of the user.2. The method according to claim 1 , whereinthe information including the upper limit of the normal range of the concentration of 2-phenoxyethanol per the unit period ...

Physically Guided Rapid Evaporative Ionisation Mass Spectrometry ("REIMS")

A method is disclosed comprising obtaining physical or other non-mass spectrometric data from one or more regions of a target using a probe. The physical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then used to generate an aerosol, smoke or vapour from one or more regions of the target.

BREATH-CONDENSATE DEVICE

A cartridge device () for collecting and analysing a breath condensate is disclosed. The device () comprises a condensation zone () to condense exhaled breath from a subject and cooling means operably connected to the condensation zone (). The device includes further discrete regions () for detection of analyte and measurement of analyte. The condensation zone () has a fluid exit connecting the condensation zone () to the discrete regions (). 1. A cartridge device for collecting and analysing a breath condensate , the device comprising a condensation zone to condense exhaled breath from a subject , the condensation zone , being operably connectable to a cooling means , the device including one or more further discrete regions for detection of analyte and measurement of analyte , the cartridge device further comprising a fluid path connecting the condensation zone to the or each discrete region.2. The cartridge device according to claim 1 , wherein the device includes analysis initiation means to detect the presence of a condensate.3. The cartridge device according to claim 1 , wherein the or each discrete region has a specified volume claim 1 , which allows the measurements to be calculated based upon the volumes.4. The cartridge device according to claim 3 , wherein the specified volume is up to 4 μl.5. The cartridge device according to claim 1 , wherein one or more discrete regions has a specified volume such that there is an analyte detection zone whose volume is less than the volume of condensate from one exhaled breath.6. The cartridge device according to claim 1 , wherein a surface of discrete region includes a surface coating claim 1 , said coating including reagents to engage the condensate and determine composition.7. The cartridge device according to claim 6 , wherein the surface coating has a thickness in a range of 1 μm to 15 μm.8. The cartridge device according to claim 1 , wherein a discrete region includes 2 or more electrodes in operable connection ...

METHOD FOR OBTAINING EXHALED RESPIRATORY SPECIMENS

The invention provides articles, devices, and methods for sampling respiratory droplets, the article comprising a material capable of adsorbing or absorbing respiratory droplets such that the contents of said respiratory droplets can be recovered for analysis. The invention allows respiratory droplets to be collected directly from any source of moisture and commonly-used devices, for example face masks and air handling systems.

Method and system for monitoring intoxication

A method and system for monitoring a user's intoxication including receiving a set of signals, derived from a set of samples collected from the user at a set of time points; providing a sobriety task to the user proximal to a time point of the set of time points; generating a performance dataset characterizing performance of the sobriety task by the user; receiving a supplementary dataset characterizing a demographic profile of the user and/or a physiological state of the user; determining a set of values of an intoxication metric, derived from the set of signals; generating a predicted temporal profile of the intoxication metric for the user based upon the set of values, the set of time points, and the supplementary dataset; generating an analysis of the user's sobriety based upon the performance dataset and the predicted temporal profile; and providing a notification to the user based upon the analysis.

Spectrometric Analysis

A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications. 1. A method of spectrometric analysis comprising:obtaining one or more sample spectra for an aerosol, smoke or vapour sample;analysing the one or more sample spectra so as to classify the aerosol, smoke or vapour sample; andchanging from a first mode of operation to a second different mode of operation so as to classify said aerosol, smoke or vapour sample.2385-. (canceled)386. The method as claimed in claim 1 , wherein the mode of operation for obtaining sample spectra is changed with respect to: (i) the condition of the target or subject that is sampled when obtaining an aerosol claim 1 , smoke or vapour sample; (ii) the type of device used to obtain an aerosol claim 1 , smoke or vapour sample; (iii) the device settings used when obtaining an aerosol claim 1 , smoke or vapour sample; (iv) the device mode of operation when obtaining an aerosol claim 1 , smoke or vapour sample; (v) the type of ambient ion or ionisation source used; (vi) the sampling time over which an aerosol claim 1 , smoke or vapour sample is obtained; (vii) the ion mode used to generate analyte ions for an aerosol claim 1 , smoke or vapour sample; (viii) the spectrometer settings used when obtaining the one or more sample spectra; (ix) the use claim 1 , number and/or type of fragmentation or reaction steps; (x) the use claim 1 , number and/or type of mass or mass to charge ratio separation or filtering steps; (xi) the use claim 1 , number and/or type of ion mobility separation or filtering steps; (xii) the use claim 1 , number and/or type of charge state separation or filtering steps; (xiii) the type of ion detector used ...

Rapid Evaporative Ionisation Mass Spectrometry ("REIMS") and Desorption Electrospray Ionisation Mass Spectrometry ("DESI-MS") Analysis of Swabs and Biopsy Samples

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

Self-Condensing pH Sensor and/or Pepsin Sensor and Catheter Apparatus

The present invention is a system for continuous real-time monitoring of a patient's breath chemistry comprising a plurality of components, including a self-condensing pH sensor distally mounted on a catheter, a pepsin sensor distally mounted on a catheter either separately or in combination with a self-condensing pH sensor, a transmitter with hydration sensing circuitry, and processing receiver/data recorder that can be a smart phone, tablet, TV, watch, wearable device, or custom designed device with wireless capability and utilizing an APP (application) that displays and records the pH and/or pepsin collected data. 1. An apparatus for monitoring of pH , said apparatus comprising:a catheter apparatus having a distal end, a proximal end, and at least one lumen that extends along the longitudinal length of said catheter apparatus and communicating with said distal end and said proximal end;a self-condensing pH sensor located in close proximity to said distal end, said self-condensing pH sensor designed to be positioned in the upper airway of a patient;a data transmitter attached to said catheter proximal end;said self-condensing sensor in electrical communication with said data transmitter; anda processing receiver/data recorder in communication with said data transmitter, said processing receiver/data recorder compromises typical cell phones, smart phones, or custom designed apparatus which includes touchscreen mobile wireless devices such as PDAs, tablets (e.g. refers to all current and future variants, revisions and generations of the Apple IPAD, Samsung Galaxy, HP, Acer, Surface, Nook, Google Nexus, Sony, Kindle and all future tablets manufactured by these and other manufactures), related handheld devices including Apple IPOD Touch, or wearable timepieces or fob watches and other similar apparatus with WIFI and wireless capability, and remote computers and controllers with wireless connectivity that can utilize an APP (application) that can display or provides a ...

METHOD AND SYSTEM FOR MONITORING PREGNANCY TOXAEMIA

A system for automatically determining pregnancy toxaemia in at least one animal in a group of animals comprises a sensor for obtaining at least one value representative of a liquid or water uptake of the at least one animal, said sensor being adapted to be positioned in the vicinity of a liquid or water supply station or on the at least one animal; and a processing unit configured for comparing the obtained at least one value representative of a liquid or water uptake of the at least one animal to a mean value representative of an average of the at least one value for the group of animals or to a value deduced therefrom; and for generating a signal and/or alert when the obtained at least one value representative of a liquid or water uptake exceeds the mean value or the value deduced therefrom by a pre-determined threshold value. 1. A pregnancy toxaemia determining system for automatically determining pregnancy toxaemia in at least one animal in a group of animals , the system comprising:a sensor for obtaining at least one value representative of a liquid or water uptake of the at least one animal, said sensor being adapted to be positioned in the vicinity of a liquid or water supply station or on the at least one animal; and comparing the obtained at least one value representative of a liquid or water uptake of the at least one animal to a mean value representative of an average of the at least one value for the group of animals or to a value deduced therefrom; and', 'generating a signal and/or alert when the obtained at least one value representative of a liquid or water uptake exceeds the mean value or the value deduced therefrom by a pre-determined threshold value., 'a processing unit configured for'}2. A pregnancy toxaemia determining system according to claim 1 , further comprising an identification unit for identifying the at least one animal claim 1 , the identification unit being adapted to be positioned in the vicinity of a liquid or water supply station ...

FLUID DIVERSION MECHANISM FOR BODILY-FLUID SAMPLING

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir. 139.-. (canceled)40. A blood transfer system , comprising:a first lumen-containing device fluidically coupleable to a patient;a transfer device having an inlet port in fluid communication with the first lumen-containing device, the transfer device defining a first fluid flow path and a second fluid flow path, the transfer device having a seal member disposed at an end portion of the first fluid flow path, a first volume of blood allowed to flow through the first fluid flow path toward the seal member when the transfer device is in a first state, the transfer device retaining the first volume of blood and allowing a second volume of blood to flow through the second fluid flow path while bypassing at least a portion of the first fluid flow path when the transfer device is in a second state; anda second lumen-containing device fluidically coupleable to a sample reservoir external to the transfer device, the second lumen-containing device configured to receive the second volume of blood from the second fluid flow path when the transfer device is in the second state.41. The blood transfer system ...

PATIENT-ENACTED SAMPLING TECHNIQUE

The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device. 191-. (canceled)92. A device for receiving bodily fluid from a subject , the device comprising:a fluid transporter comprising a microneedle;a fluid storage reservoir in fluidic communication with the fluid transporter; andan indicator indicative of the time fluid is contained within the fluid storage reservoir.93. The device of claim 92 , wherein the indicator is able to record the time when fluid enters the fluid storage reservoir.94. The device of claim 92 , wherein the indicator is able to record the duration fluid is present within the fluid storage reservoir.95. The device of claim 92 , wherein the indicator is able to produce a signal indicative of a condition of fluid within the fluid storage reservoir.96. The device of claim 95 , wherein the signal includes a visual signal.97. The device of claim 95 , wherein the signal includes a color signal.98. The device of claim 92 , wherein the indicator is activated upon activation of the device.99. The device of claim 92 , wherein the indicator is activated upon introduction of fluid into the fluid storage reservoir.100. The device of claim 92 , wherein the indicator is in electronic communication with a sensor in sensing communication with the fluid storage reservoir.101. The device of claim 92 , ...

SUPPORT BODY, BODY FLUID COLLECTION SET, AND BODY FLUID COLLECTION METHOD

Disclosed are a support body, a body fluid collection set, and a body fluid collection method that can easily support a body fluid collection sheet even by a non-physician. The support body includes a first sheet having an adhesive surface for adhering the body fluid collection sheet , and a second sheet adhered to the first sheet . The adhesive surface of the first sheet is adhered to the body fluid collection sheet so that the first sheet is separated from the skin and the body fluid collection sheet is peeled off from the skin . Thereafter, the second sheet is superposed on the adhesive surface , and the body fluid collection sheet is supported on the support body 1. A support body for supporting a body fluid collection sheet for collecting a body fluid , comprising:a first sheet separated from the body fluid collection sheet and having an adhesive surface for adhering the body fluid collection sheet; anda second sheet to be overlaid on the adhesive surface, whereinthe support body configured to support the body fluid collection sheet when the body fluid collection sheet is separated from the skin.2. The support body according to claim 1 , whereinthe body fluid collection sheet comprises a body fluid collection body that adheres to the skin and collects bodily fluids; andwherein in the second sheet, holes through the second sheet provided in a region in which the body fluid collection body is positioned when overlaid on the first sheet are formed, andwherein the second sheet comprises a peeling member disposed peelably on a surface on the side opposite to a surface of the second sheet overlaid on the first sheet, such that the peeling member occludes the holes from the opposite surface.3. The support body according to claim 1 , whereinthe second sheet is integrally provided with the first sheet so as to foldably overlap with the adhesive surface.4. The support body of claim 3 , further comprising:a notch part provided at the boundary of the first sheet and the ...

SENSOR DEVICES AND SYSTEMS FOR MONITORING MARKERS IN BREATH

The disclosure relates to devices, systems and methods for detecting markers in breath, more specifically volatile and non-volatile markers associated with pulmonary diseases such as, for example, asthma, chronic obstructive pulmonary disease (COPD), or cystic fibrosis (CF), in exhaled breath condensate (EBC). 1. An article for measuring a disease marker in exhaled breath condensate (EBC) comprising ,(a) a vehicle chamber containing a vehicle for a probe;(b) an auxiliary chamber that is physically separated from the vehicle chamber via a first separator, wherein the auxiliary chamber contains the probe that is specific to the marker;(c) a reaction chamber that is physically separated from the vehicle chamber or the auxiliary chamber or both the reaction chamber and the auxiliary chamber via a second separator, wherein the reaction chamber contains an surface for detection of the interaction between the probe and the marker; and(d) a detector for detecting a signal issued from said reaction chamber.2. The article of claim 1 , wherein the marker is hydrogen peroxide (HO) or a derivative thereof selected from peroxide anion (O) claim 1 , or a peroxide radical (.OH).3. The article of claim 1 , wherein the probe comprises a marker-reactive chemical and a dye.4. The article of claim 3 , wherein the dye is activated by a product of the reaction between the marker and the marker-reactive chemical.5. The article of claim 4 , wherein the dye is activated in situ.6. The article of claim 1 , wherein the marker is HOand the probe comprises HO-reactive chemical and a dye.7. The article of claim 6 , wherein the reactive chemical is bis(2 claim 6 ,4 claim 6 ,6-trichlorophenyl) oxalate claim 6 , bis(2-carbopentyloxy-3 claim 6 ,5 claim 6 ,6-trichlorophenyl)oxalate claim 6 , oxalic acid bis[2 claim 6 ,4 claim 6 ,5-trichloro-6-(pentyloxycarbonyl)phenyl]ester claim 6 , bis(2-itrophenyl) oxalate claim 6 , bis(2 claim 6 ,4-dinitrophenyl) oxalate claim 6 , bis(2 claim 6 ,6-dichloro-4- ...

SENSOR FOR ANALYTES IN A FLUID AND RELATED METHOD

According to one aspect of the invention, the apparatus comprises a fluid collecting device configured to receive a sample of breath; a conditioning device coupled to the fluid collecting device and configured to receive the sample of breath and condition the sample with respect to at least one of temperature, flow rate, pressure, humidity, and concentration; and a sensing device coupled to the conditioning device and configured to receive the conditioned sample, wherein the sensing device includes a nanoparticle-based sensor and further whereby the analyte interacts with the sensing device to cause a change that is sensed by the sensing device and wherein the change comprises information useful in characterizing the analyte. Preferably, the apparatus is hand-held and characterizing the analyte is useful for health monitoring. 1. An apparatus for sensing an analyte in breath , the apparatus comprising:a fluid collecting device configured to receive a sample of breath;a conditioning device coupled to the fluid collecting device and configured to receive the sample of breath and condition the sample with respect to at least one of temperature, flow rate, pressure, humidity, and concentration;a sensing device coupled to the conditioning device and configured to receive the conditioned sample, wherein the sensing device includes a nanoparticle-based sensor;whereby the analyte interacts with the sensing device to cause a change that is sensed by the sensing device and wherein the change comprises information useful in characterizing the analyte.2. The apparatus of wherein the apparatus is hand-held.3. The apparatus of wherein the conditioning device is disposed in a hand-held apparatus and conditions for humidity.4. The apparatus of wherein the conditioning device is disposed in a hand-held apparatus and conditions for concentration.5. The apparatus of wherein the conditioning device is disposed in a hand-held apparatus and conditions for flowrate and pressure.6. The ...

Liquid Trap or Separator for Electrosurgical Applications

An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices. 1. Apparatus for mass spectrometry and/or ion mobility spectrometry comprising:a first device arranged and adapted to generate aerosol, smoke or vapour from a target;a mass and/or ion mobility analyser;one or more second devices arranged and adapted to aspirate aerosol, smoke or vapour and/or liquid to or towards the analyser; anda liquid trap or separator located between said first device and said mass and/or ion mobility analyser, wherein said liquid trap or separator is arranged and adapted to capture and/or discard liquid aspirated by said one or more second devices.28-. (canceled)9. Apparatus as claimed in claim 1 , wherein said first device comprises one or more electrodes claim 1 , and wherein said first device is arranged and adapted to generate said aerosol claim 1 , smoke or vapour from said target by contacting said target with said one or more electrodes.10. Apparatus as claimed in claim 9 , wherein said one or more electrodes comprises either: (i) a monopolar device claim 9 , wherein said apparatus optionally further comprises a separate return electrode; (ii) a bipolar device; or (iii) a multi-phase RF device claim 9 , wherein said apparatus optionally further comprises a separate return electrode or electrodes.11. (canceled)12. Apparatus as claimed in claim 9 , further comprising a device arranged and adapted to apply an AC or RF voltage to said one or more electrodes in order to generate said aerosol claim 9 , smoke or vapour.13. (canceled)14. (canceled)15. Apparatus as claimed in claim 1 , whereinsaid first device comprises a laser ...

FLUID DIVERSION MECHANISM FOR BODILY-FLUID SAMPLING

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir. 139.-. (canceled)40. A blood transfer system , comprising:an access device at least partially insertable into a patient;a first tubing fluidically coupleable to the access device;a transfer device having an inlet port fluidically coupled to the first tubing, the transfer device having a seal member disposed at an end portion of a first fluid flow path and at least partially defining an inner volume, the inner volume receiving a first volume of blood flowing through the first fluid flow path toward the seal member when the transfer device is in a first state, the transfer device allowing a second volume of blood to flow from the inlet port via a second fluid flow path toward an outlet port while bypassing the inner volume when the transfer device is in a second state; anda second tubing fluidically coupleable to a sample reservoir external to the transfer device, the second volume of blood flowing from the second fluid flow path into the second tubing when the transfer device is in the second state.41. The blood transfer system of claim 40 , wherein the inlet port defines a lumen claim 40 , ...

SYSTEM AND METHOD OF DETERMINING A CONDITION OF A SUBJECT BASED ON VOLATILE ORGANIC COMPOUNDS

Disclosed is a method of determining a condition of a subject based on Volatile Organic Compounds (VOCs) in a gaseous phase, originating from the subject. The method may include: receiving from one or more sensors a set of sensor signals in response to exposing the one or more sensors to a sample of the VOCs; extracting one or more feature values from the set of sensor signals; receiving a classification model, trained to classify samples of VOCs based on the one or more extracted feature values correlated to one or more condition of the subject; associating the one or more extracted features received from the set of sensor signals with one or more classes of the classification model; and determining the condition of the subject based on the association. 1. A method of determining a condition of a subject based on Volatile Organic Compounds (VOCs) in a gaseous phase , originating from the subject , the method comprising:receiving from one or more sensors a set of sensor signals in response to exposing the one or more sensors to a sample of the VOCs;extracting one or more feature values from the set of sensor signals;receiving a classification model, trained to classify samples of VOCs based on the one or more extracted feature values correlated to one or more condition of the subject;associating the one or more extracted features received from the set of sensor signals with one or more classes of the classification model; anddetermining the condition of the subject based on the association.2. The method of claim 1 , wherein the condition is at least one of: a medical condition of the subject claim 1 , a mental condition of the subject claim 1 , an identity of the subject and a general wellbeing of the subject.3. The method of or claim 1 , further comprising:receiving additional data ;associating the received additional data with one or more classes of the classification model; anddetermining the condition of the subject also based on the additional data association. ...

FLUID DIVERSION MECHANISM FOR BODILY-FLUID SAMPLING

An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir. 1. A device for procuring bodily-fluid samples from a patient , the device comprising:a housing including a proximal end portion and a distal end portion and defining an inner volume therebetween, the housing having an inlet port configured to be fluidically coupled to the patient, and an outlet port configured to be fluidically coupled to a sample reservoir;a fluid reservoir disposed in the inner volume and configured to receive and isolate a first volume of bodily-fluid withdrawn from the patient;a flow control mechanism disposed in the housing and defining a first lumen and a second lumen, the flow control mechanism configured for rotational movement from a first configuration, in which the inlet port is placed in fluid communication with the fluid reservoir such that bodily-fluid can flow from the inlet port, through the first lumen and to the fluid reservoir, to a second configuration, in which the inlet port is placed in fluid communication with the outlet port such that the bodily-fluid can flow from the inlet, through the second lumen and to the outlet port; andan actuator operably ...

METHODS AND DEVICES FOR GASEOUS SAMPLE COLLECTION AND STORAGE

Methods and devices for gaseous sample collection and storage. In an exemplary embodiment of a device for collecting and storing a gaseous sample of the present disclosure, the device comprises a container comprised of impermeable material, a mating section in fluid communication with the container, and a one-way valve disposed in the mating section. 1. A device for collection and storage of a gaseous sample , the device comprising:a container;a mating section in communication with the container; anda one-way valve disposed in the mating section.2. The device of claim 1 , further comprising:a gas binding material disposed inside the container.3. The device of claim 1 , wherein the mating section comprises a sealing means.4. The device of claim 1 , wherein the mating section further comprises a first end in communication with the container.5. The device of claim 4 , wherein the mating section comprises a neck with at or about a centimeter diameter and second end which is flared outward.6. A device for collection and storage of a gaseous sample claim 4 , the device comprising:a container comprising an opening;a mating section in communication with the opening;a one-way valve disposed at or near the opening of the container.7. The device of claim 6 , wherein the mating section has a first end attached to the opening and a second end flared like a plunger.8. The device of claim 6 , further comprising:a gas binding material disposed inside the container and configured to bind to the gas sample and hold the gas sample in a non gaseous state.9. The device of claim 6 , wherein the one-way valve has a minimal opening and a minimal closing pressure.10. The device of claim 9 , wherein the minimal opening and minimal closing pressure is at or between 1-5 mmHg11. The device of claim 6 , wherein the mating section is removably attached to the container.12. The device of claim 6 , wherein the mating section comprises a sealing means and said sealing means may be soft or semi-soft. ...

Transdermal sampling strip and method for analyzing transdermally emitted gases

Transdermally emitted gasses are detected by applying a dermal sampling strip to the skin of a biological subject, capturing the gasses in a vapor space in the dermal sampling strip, and analyzing for at least one such gas captured in the vapor space of the dermal sampling strip. Analysis is preferably performed using an electrocatalytic cell, which can be mounted on the dermal sampling strip and form a wall of the vapor space.

Method for analyzing biomaterials based on image analysis and personalization data

An electronic device and a control method of an electronic device are provided. The control method includes obtaining an image on the diagnostic kit through a camera included in the electronic device, the obtaining of the image based on receiving a user command for photographing a diagnostic kit including at least one test line discolored according to a reaction between a sample collected from a body of a user and a reagent, and a plurality of tone distinction markers with tones different from one another, obtaining a first color value on the at least one test line included in the obtained image and a second color value on each of the plurality of tone distinction markers, obtaining a first deviation information on a photographing environment of the obtained image, correcting a first data to obtain a biometric information measurement value, and obtaining a diagnostic result corresponding to the measurement value.

System and method for non-invasive monitoring

This invention describes a method and device for big data approach in integrated patient care. It combines breath and saliva chemical analysis with physical signs analysis to use big data analysis for diagnosing a disease state based on the determined concentration of the group of gas compounds and physical parameters. 1. A method comprising:collecting a sample of exhaled breath from a subject;collecting a sample of saliva for chemical analysis;collecting physical parameters from a subject;determining concentrations of a group of chemical compounds in the collected sample; anddiagnosing a disease state based on the determined concentration of the group of chemical compounds and physical parameters.2. A method comprising:collecting a set of samples of exhaled breath and physical parameters from a subject over aperiod of time; determining normalized concentrations of a group of chemical compounds ineach collected sample of exhaled breath and saliva;determining a change in the normalized concentrations of the group of chemical compounds over the period of time; determining a change of physical parameters over the period of time; andevaluating an disease state of the subject based on the determined change in the normalized concentration of the group of chemical compounds and physical parameters.3. A device , comprising:a breath collector configured to receive exhaled breath from a subject;one or more sensors configured to output a concentration of a group of gas compounds in the inhaled breath and output a concentration of said group of compounds in the received exhaled breath; andone or more sensors configures to detect physical parameters (including at least one of the Pulse Rate, Breathing rate, Thermometer, Blood pressure, tremor and humidity parameters) from the subject; andone or more sensors configures to detect chemicals in collected samples of saliva, anda processor operably coupled to the one or more sensors and further configured to take parameters of said ...

HYDROPHOBIC GAS PERMEABLE FILTER ASSEMBLY FOR MICROFILTRATION OF EXHALED GASES

A filter assembly for filtering an exhaust gas and preventing contaminates from reaching a medical sampling instrumentation. The filter assembly comprises a hydrophobic filter media component; a first enclosure with an inlet (second) port communicating with an inwardly facing surface carrying a plurality of first channels, a first annular sidewall surrounding the first channels, and the first annular sidewall carrying a first mating feature at a free end thereof; a second enclosure having an outlet (first) port which communicating with an inwardly facing surface carrying a plurality of second channels, and a second mating feature surrounding the second channels. The first and second enclosures matingly engaging with one another so that the first and the second mating features mate with one another and the first and second enclosures define a filter chamber therebetween which captively retains the hydrophobic filter media component within the filter chamber having minimal dead space. 1. A filter assembly for filtering an exhaust gas and preventing a contaminate from reaching a medical sampling instrumentation , the filter assembly comprising:a hydrophobic filter media component;a first enclosure having a first port communicating with an inwardly facing surface carrying a plurality of first channels, a first annular sidewall surrounding the first channels, and the first annular sidewall carrying a first feature at a free end thereof;a second enclosure having a second port communicating with an inwardly facing surface carrying a plurality of second channels, and a mating second feature surrounding the second channels; andthe first and second enclosures matingly engaging with one another so that the first and the second mating features mate with one another and the first and second enclosures define a sealed filter chamber therebetween which captively retains the hydrophobic filter media component within the filter chamber such that the filter assembly has minimal dead ...

Health and Wellness Monitoring System for Multiple Users

The invention is a system for monitoring and reporting health and wellness data. The system includes a pre-qualification mechanism, whereby an individual can become a pre-qualified user. The system also includes a plurality of stations, with each station including a user identification unit to determine if the user is a pre-qualified user and, if so, identify that pre-qualified user and a toilet. The toilet includes a bowl to receive excreta, two or more sensors configured to detect properties of the excreta from a pre-qualified user, and a bowl clearing mechanism to dispose of the excreta. Each station also includes a station processor configured to receive signals from the two or more sensors and from the user identification unit to create excreta event data for the identified pre-qualified user. Each station also includes a station data communication unit. The system also includes a central base that, in turn, includes a central base data receiving unit configured to receive excreta event data via the station data communication unit from each of the plurality of stations. The central base also includes a central base data storage unit configured to store excreta event data. The central base further includes a central base data processor configured to process the excreta event data for each pre-qualified user and produce health and wellness data for that pre-qualified user. The central base still further includes a central base data reporting unit configured to report health and wellness data to the appropriate pre-qualified user. 1. A system for monitoring and reporting health and wellness data comprising:a pre-qualification mechanism, whereby an individual can become a pre-qualified user; a user identification unit to determine if the user is a pre-qualified user and, if so, identify that pre-qualified user;', a bowl to receive excreta;', 'two or more sensors configured to detect properties of the excreta from, 'a toilet comprising'}, 'a bowl clearing mechanism ...

INLET INSTRUMENTATION FOR ION ANALYSER COUPLED TO RAPID EVAPORATIVE IONISATION MASS SPECTROMETRY ("REIMS") DEVICE

An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet. 1. An apparatus comprising:a first device arranged and adapted to emit a stream of electrically charged droplets towards a target in use;a transfer capillary arranged and adapted to transfer ions generated from said target towards an ion analyser or mass spectrometer; anda heating device arranged and adapted to heat either: (i) a capillary of said first device; (ii) said stream of electrically charged droplets emitted from said first device; (iii) said target; and/or (iv) said transfer capillary.2. An apparatus as claimed in claim 1 , wherein said first device comprises a Desorption Electrospray Ionisation (“DESI”) device.3. An ion inlet device as claimed in claim 1 , wherein said heating device comprises a heater.4. An ion inlet device as claimed in claim 3 , wherein said heater comprises a wire heater.5. An ion inlet device as claimed in claim 1 , wherein said heating device is arranged and adapted to heat said capillary of said first device claim 1 , said stream of electrically charged droplets emitted from said first device claim 1 , said target or said transfer capillary to a temperature of above ambient temperature claim 1 , and/or to a temperature of at least 30° C. claim 1 , 50° C. claim 1 , 100° C. claim 1 , 200° C. claim 1 , 300° C. claim 1 , 400° C. claim 1 , 500° C. or greater than 500° C.6. An ion inlet device as claimed in claim 1 , wherein said heating device is located adjacent an inlet to said ion analyser or mass spectrometer.7. An ion inlet device as claimed in claim 6 , wherein said inlet forms the entrance to a first vacuum stage of said ion analyser or mass ...

APPARATUSES AND METHODS FOR EXTRACTING CHEMICALS FROM BODILY CAVITIES AND BREATH

A chemical extraction apparatus has absorbent material for absorbing or adsorbing volatile chemicals from a breath of a user. The chemical extraction apparatus is positioned within such that breaths from the user flow over the absorbent material thereby causing volatile chemicals in the breaths to absorb or adsorb into the absorbent material. The absorbent material is then analyzed to determine the amount of chemicals absorbed or adsorbed into the absorbent material. Based on such analysis, various diseases or conditions can be detected or diagnosed. 117-. (canceled)18. A pacifier , comprising:a support element; anda nipple for insertion into an oral cavity of a user, the nipple coupled to the support element and having absorbent material for absorbing or adsorbing trace levels of volatile chemicals in breaths of the user.19. The pacifier of claim 18 , further comprising a handle coupled to the support element.20. The pacifier of claim 18 , wherein the nipple has a cavity claim 18 , and wherein the absorbent material is within the cavity.21. The pacifier of claim 20 , wherein the nipple has a hole for allowing the breaths to pass through the hole into the cavity.22. The pacifier of claim 21 , wherein the absorbent material is attached to an inner wall of the nipple by an arm extending from the inner wall.23. A method claim 21 , comprising:providing a pacifier having a nipple, wherein the nipple has absorbent material for absorbing or adsorbing trace levels of volatile chemicals in breaths of a user;inserting a nipple of a pacifier into an oral cavity of the user such that the trace levels of the volatile chemicals are absorbed or adsorbed into the absorbent material;analyzing the absorbent material;identifying the trace levels of the volatile chemicals based on the analyzing; anddiagnosing a condition of the user based on the identified trace levels of the volatile chemicals.24. The method of claim 23 , wherein the nipple has a cavity claim 23 , and wherein the ...

Instantaneous olfactory disease detection system and method of use of detection

A bacterial and microorganism detector apparatus and system to provide quick and efficient sampling of a patient, or an attendee at an event, that allows for a canine or other animal to test the breath to determine the existence and presence of any deleterious particles, that may be present therein. The apparatus includes an intake device, in which the party breathes into an air drawing device such as a spirometer, or fan, a reservoir for collecting the sampled breath, a discard valve in the event that excessive breath has been taken in, an overflow valve from the reservoir, which then subjects the final segment of breath to filtration, which the animal can sniff for detection purposes, just before the remaining sample is discharged from the apparatus. The spirometer functions to withdraw air from the lungs of the treated party, for the sampling and testing purposes.

SYSTEMS, COMPOSITIONS, AND METHODS FOR TARGETED CHALLENGE AND IDENTIFICATION OF GUT MICROBIOTA

Identifying gut microbiota in a specific site of the gut through production of a measurable response following introduction of a challenge agent to the specific site of the gut is disclosed. A system embodiment includes, but is not limited to, a composition including the challenge agent; and an emissions analysis device including a body structure defining an orifice configured to receive a biofluid; a sensor operably coupled to the orifice and configured to detect at least one analyte from the biofluid and generate one or more sense signals, the one or more sense signals associated with the measurable response; circuitry operably coupled to the sensor and configured to receive the one or more sense signals associated with the measurable response; and a reporter operably coupled to the circuitry and configured to generate one or more communication signals associated with at least one targeted microbe. 1. A system , comprising: a challenge agent configured to elicit a measurable response by the at least one targeted microbe at the specific site in the gut, the measurable response detectable in a bodily gaseous emission; and', 'a controlled release system encompassing at least a portion of the challenge agent, the controlled release system configured to access the specific site of the gut; and, 'a composition for detecting at least one targeted microbe in a specific site of the gut, the composition including'} a body structure defining an orifice configured to receive the bodily gaseous emission;', 'a sensor operably coupled to the orifice and configured to detect at least one analyte from the bodily gaseous emission and generate one or more sense signals, the one or more sense signals associated with the measurable response;', 'circuitry operably coupled to the sensor and configured to receive the one or more sense signals associated with the measurable response; and', 'a reporter operably coupled to the circuitry and configured to generate one or more communication ...

APPARATUS FOR THE DETECTION OF CARBON DIOXIDE

The present invention relates to an apparatus () apparatus for the detection of carbon dioxide. It is described to place () a part of a housing in contact with a skin area of a patient. the part of the housing and a gas measuring chamber within the housing are configured such that gases diffusing through the skin area of the patient enter the gas measuring chamber. radiation is emitted () from a radiation source within the housing, wherein at least some of the radiation emitted by the radiation source enters the gas measuring chamber. The radiation entering the gas measuring chamber has wavelengths that extend over an absorption band of carbon dioxide and has wavelengths that extend over a region other than the absorption band of carbon dioxide. A radiation filter is positioned () relative to the gas measuring chamber such that an interaction radiation path is defined between the radiation source through the gas measuring chamber to the radiation filter. A first radiation detector is positioned () relative to the radiation filter such that a first detection radiation path is defined that is in addition to the interaction radiation path, and a second radiation detector is positioned relative to the radiation filter such that a second detection radiation path is defined that is in addition to the interaction radiation path. The radiation filter is configured such that radiation in the first detection radiation path has a wavelength that extends over the absorption band of carbon dioxide and with an intensity of radiation that extends over the region other than the absorption band being significantly less than that in the interaction radiation path. The radiation filter is also configured such that radiation in the second detection radiation path has a wavelength that extends over the region other than the absorption band of carbon dioxide and with an intensity of radiation that extends over the absorption band being significantly less than that in the interaction ...

WEARABLE APPARATUS ATTACHING ON TOOTH AND THE SENSING DEVICE FIXING AT TOOTH

Disclosed is a tooth-attach wearable device. The tooth-attach wearable device includes a body configured to attach to a tooth; a sensor device provided to the body, and configured to sense biometric information of a patient; and a communication controller provided to the body, and configured to store the biometric information sensed at the sensor device as data, and to transmit the stored data. 1. A tooth-attach wearable device , the wearable device comprising:a body configured to attach to a tooth;a sensor device provided to the body, and configured to sense biometric information of a user; anda communication controller provided to the body, and configured to store the biometric information sensed at the sensor device as data, and to transmit the stored data.2. The wearable device of claim 1 , wherein the sensor device comprises:a sensor head configured to contact with a tongue or gums of the user or be exposed inside the oral cavity, and to sense the biometric information of the user by sensing the saliva or a temperature of the user; anda sensor chip configured to couple with the sensor head.3. The wearable device of claim 2 , wherein at least one of a thermoelement claim 2 , a piezoelectric element claim 2 , a chemical substance detection element claim 2 , and a marker sensor is provided to the sensor head.4. The wearable device of claim 1 , wherein the communication controller comprises:a data storage configured to store the biometric information of the user sensed at the sensor device as data; anda data transmitter configured to remotely transmit the data stored in the data storage.5. The wearable device of claim 4 , further comprising:a monitoring device configured to display the data transmitted from the data transmitter.6. A tooth-attach wearable device having a tooth attachment corresponding to a shape of a tooth claim 4 , the wearable device comprising:a sensor head configured to couple with one surface of the tooth attachment, to be exposed inside the ...

Analyzing and correlating spectra, identifying samples and their ingredients, and displaying related personalized information

Obtaining two spectra from the same sample under two different conditions at about the same time for comparison, where at least one of the spectra measures magnitudes of electromagnetic radiation on at least four different ranges or weightings of wavelengths or frequencies. Classifying a sample using these spectra obtained by a user, and using spectra obtained from different samples by different users to identify the sample. Computing correlations between data related to food and ingredient consumption by one or more users over time, and data related to passive personal log data, user entered feedback, user interaction data or personal information related to those users, and detecting: foods or ingredients to which a user may be allergic or intolerant; a possible medical condition of a user; a possible link between food and ingredient consumption and a medical or health condition; or a similarity between at least two such users.

SYSTEMS, DEVICES, AND METHODS FOR DETECTING EARLY SHOCK

Systems, devices, and methods to measure interstitial concentration of selected compounds over time to provide early detection of shock are described. In an example method, interstitial fluid is obtained from a subject. Analytes are detected in the interstitial fluid. At least one of the analytes corresponds to hypoxia of a tissue of the subject and at least one other analyte corresponds to vascular permeability of the subject. The example method further includes determining whether the subject is in shock based on a computing model and the detected analytes and generating an alert based on whether the subject is in shock. Treatments can be administered following the alert generation.

METHOD AND SYSTEM FOR TRANSDERMAL ALCOHOL MONITORING

A method for monitoring intoxication of a user, the method including: receiving a set of samples from a body region of a user; generating an intoxication metric based on the set of samples; and providing a notification to the user based on the intoxication metric. The method can additionally or alternatively include: modifying operation of the transdermal alcohol sensing device based on the intoxication metric; determining contextual data; maintaining a hydration level of the transdermal alcohol sensing device; and any other suitable processes. A system for monitoring intoxication of a user including a sensor and a housing. The system can additionally or alternatively include any or all of: an inlet, a fastener, an electronics subsystem, a user device, and/or any other suitable component.

INTERPENETRATING MICROSTRUCTURES FOR NANOCHANNEL-BASED SAMPLING AND/OR CARGO DELIVERY

Provided herein are devices and methods for topically and controllably delivering cargo or collecting samples into or from biological tissues, particularly the skin. These devices permit delivery of cargo and collection of samples from cell layers deep within a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.

Apparatuses, systems, and methods for sample capture and extraction

Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

Apparatuses, systems, and methods for sample capture and extraction

Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

Mild Traumatic Brain Injury Diagnostic Immunochromatographic Microneedle Patch

A diagnostic transdermal patch which utilizes a microneedle array and an integrated biochemical assay to detect the presence of biomolecules which are associated with a specific condition or disease, such as mild traumatic brain injury (MTBI). 1. A diagnostic patch comprising:a microneedle array configured to obtain a sample of interstitial fluid from a subject; anda lateral flow assay in fluid connection with the microneedle array wherein the lateral flow assay is configured to detect the presence of an analyte in the sample of interstitial fluid.2. The diagnostic patch of wherein presence of the analyte is indicative of mild traumatic brain injury (MTBI).3. The diagnostic patch of wherein the microneedle array and lateral flow assay are all contained within a substrate.4. The diagnostic patch of wherein the substrate provides the fluid connection between the microneedle array and the lateral flow assay.5. The diagnostic patch of wherein the substrate comprises a bottom surface that makes contact with the skin of the subject and comprises an adhesive configured to non-permanently adhere the patch to the subject's skin.6. The diagnostic patch of wherein the patch is round in shape and the microneedle array extends from the center of the bottom surface of the substrate.7. The diagnostic patch of wherein the lateral flow assay comprises concentric rings of diagnostic elements radiating outwards from the center of the substrate.8. The diagnostic patch of wherein the diagnostic elements comprise a conjugate region claim 7 , a test region claim 7 , and a control region.9. The diagnostic patch of wherein the conjugate region is obscured from view.10. The diagnostic patch of wherein the conjugate region comprises one or more antibodies which are biomarkers of MTBI.12. The diagnostic patch of wherein a biomarker is selected from the group consisting of: S100B claim 10 , UCH-L1 claim 10 , GFAP claim 10 , 1 alpha-II spectrin claim 10 , tau claim 10 , miR-182-5p claim 10 , miR ...

VOLATILE ORGANIC COMPOUND DETECTION DEVICE

A volatile organic compound detection device includes a collector comprising: a collector material configured to collect volatile organic compounds given off from a patient's skin; a heater comprising a heating element, the heating element configured to emit a thermal pulse to desorb the volatile organic compounds from the collector material; and a flow channel configured to receive the volatile organic compounds desorbed by the heater; and a fastener configured to secure the collector to the patient's skin. 1. A volatile organic compound detection device comprising: ["a collector material configured to collect volatile organic compounds given off from a patient's skin;", 'a heater comprising a heating element, the heating element configured to emit a thermal pulse to desorb the volatile organic compounds from the collector material; and', 'a flow channel configured to receive the volatile organic compounds desorbed by the heater; and, 'a collector comprisinga fastener configured to secure the collector to the patient's skin.2. The volatile organic compound detection device of claim 1 , wherein the fastener comprises a band.3. The volatile organic compound detection device of claim 1 , further comprising an inner layer disposed between the collector material and the patient's skin claim 1 , the inner layer configured to prevent the collector material from contacting the patient's skin.4. The volatile organic compound detection device of claim 3 , wherein the inner layer is a mesh layer.5. The volatile organic compound detection device of claim 3 , further comprising an outer layer configured to isolate the collector material from an external environment claim 3 , wherein the collector material is disposed between the inner layer and the outer layer.6. The volatile organic compound detection device of claim 1 , further comprising a separator claim 1 , the separator comprising a gas chromatography column configured to separate mixtures of the volatile organic ...

Animal Olfactory Detection of Disease as Control for Health Metrics Collected by Medical Toilet

We disclose a medical toilet that comprises one or more medical devices and a control for the metrics they collect. The medical devices may be used to collect metrics relevant to a user's health status. The medical toilet further comprises a conduit through which volatile organic compounds travel from the toilet bowl to the environment outside the toilet. An animal trained to identify the scent of bodily waste collected from a user that is afflicted with a disease perceives the scent of the user's bodily waste traveling through the conduit and performs a defined act upon perceiving the disease scent. The metric collected by the medical device(s) may be used to diagnose the same disease as that which the animal is trained to identify. The diagnosis provided by the animal by way of the conduit acts as a control for the metric collected by the medical device. 1. A method of providing a control for a first health metric collected by a medical toilet for use in diagnosing a disease in a user comprising the steps of: a toilet bowl;', 'a toilet seat;', 'a medical device which measures a first health metric, wherein the first metric is an indicator of the disease in a user;', wherein the opening is defined by a frame, the frame comprising a first side in communication with an environment outside the toilet bowl and a second side in communication with an environment inside the toilet bowl;', 'wherein the opening connects the environment inside the toilet bowl with the environment outside the toilet bowl; and', 'wherein the opening defines a conduit to transfer volatile organic compounds from the toilet bowl to the environment outside the toilet;, 'an opening within a side of the toilet;'}, 'a scent dispenser, the scent dispenser comprising], 'providing a medical toilet, the toilet comprising smell the air being emitted from the scent dispenser;', 'identify a scent that is associated with the disease; and', 'perform a defined act when the animal perceives scent associated ...

System for detecting and logging of flatulence for health indication

A system is provided for collecting and logging the frequency of flatulence of a person in a selected time period as well as the duration of each occurrence of flatulence. The log entries provide determination of the body cells signaling of the person indicative of the person's health condition whereby underlying diseases may be detected and treated in their early stage. 1. A system for detecting and logging the occurrence of flatulence comprising:a gas collecting device mountable underneath a sitting means for receiving flatulence released by a user sitting on said sitting means;a hydrogen sulfide sensor connected to said gas collecting device and operative to detect existence of hydrogen sulfide gas in said flatulence;a frequency detector connected to said hydrogen sulfide sensor for detecting frequency of occurrence of flatulence in a selected period of time;a duration detector connected to said hydrogen sulfide sensor for detecting duration of each occurrence of flatulence;a logging device connected to said frequency detector and operative for receiving an event signal from said frequency detector indicative of number of times flatulence occurring in said selected period of time; and said duration device also forwarding a duration signal to said logging device indicative of the length of time of each occurrence of the flatulence;a display device connected to said logging device, said display device and said logging device being operative by a user control panel connected to said logging device and said display device to display entries of said occurrence of frequency of occurrence of flatulence and duration of occurrence of each flatulence in said selected logging period of time for representing body cells signaling activity indicative of health condition of said user.2. A system according to wherein said hydrogen sulfide sensor is located within said gas collecting device.3. A system according to including a removable bacteria cartridge connected to said ...

APPARATUSES AND METHODS FOR EXTRACTING CHEMICALS FROM BODILY CAVITIES AND BREATH

A chemical extraction apparatus has absorbent material for absorbing or adsorbing volatile chemicals from a breath of a user. The chemical extraction apparatus is positioned within such that breaths from the user flow over the absorbent material thereby causing volatile chemicals in the breaths to absorb or adsorb into the absorbent material. The absorbent material is then analyzed to determine the amount of chemicals absorbed or adsorbed into the absorbent material. Based on such analysis, various diseases or conditions can be detected or diagnosed. 117-. (canceled)18. A pacifier , comprising:a support element; anda nipple for insertion into an oral cavity of a user, the nipple coupled to the support element and having absorbent material for absorbing or adsorbing trace levels of volatile chemicals in breaths of the user.19. The pacifier of claim 18 , further comprising a handle coupled to the support element.20. The pacifier of claim 18 , wherein the nipple has a cavity claim 18 , and wherein the absorbent material is within the cavity.21. The pacifier of claim 20 , wherein the nipple has a hole for allowing the breaths to pass through the hole into the cavity.22. The pacifier of claim 21 , wherein the absorbent material is attached to an inner wall of the nipple by an arm extending from the inner wall.23. A method claim 21 , comprising:providing a pacifier having a nipple mounted on a support element, wherein the nipple has absorbent material for absorbing or adsorbing trace levels of volatile chemicals in breaths of a user;inserting the nipple, including the absorbent material, of the pacifier into an oral cavity of the user such that the trace levels of the volatile chemicals are absorbed or adsorbed into the absorbent material;analyzing the absorbent material with analytical instrumentation;identifying, with the analytical instrumentation, the trace levels of the volatile chemicals based on the analyzing;providing an output from the analytical instrumentation ...

Networked intoxication vehicle immobilization

A vehicle immobilization system includes a detection element operable to detect a level of an intoxicant in a user's breath. A control module is operable to receive a signal from the detection element indicating the level of intoxicant in the user's breath, and to selectively restrict operation of a vehicle based on the level of intoxicant in the user's breath exceeding a threshold. A wireless relay is operable to replace a standard relay in the vehicle, and to wirelessly communicate with the control module such that the control module is operable to control the wireless relay to selectively restrict operation of the vehicle.

BREATHALYZER COACHING AND SETUP METHODOLOGY

Methods of coaching a user of a breathalyzer to make use of correct blowing technique when blowing into the breathalyzer are provided. Methods of setting up a breathalyzer such that it adjusts a breathalyzer's parameters to account for jurisdictional variations in blood and/or breath alcohol limits and other standards are also provided. 1. A breathalyzer coaching methodology for coaching a user of a breathalyzer to make use of correct blowing technique , the method comprising:gathering a sample breath provided by a user;determining the instantaneous volume V, flowrate F and pressure P of the sample breath as it is being provided by the user;{'b': '1', 'determining whether the determined sample breath instantaneous volume V is less than a minimum threshold breath sample volume V;'}determining whether the determined sample breath instantaneous flowrate F is greater than a maximum threshold breath sample flowrate FMAX, between a maximum threshold breath sample flowrate and a minimum threshold breath sample flowrate FMIN, or less than the minimum sample breath flowrate FMIN;determining whether the determined sample breath instantaneous pressure P is greater than a maximum threshold breath sample pressure PMAX, between a maximum threshold breath sample pressure and a minimum threshold breath sample pressure PMIN, or less than the minimum sample breath pressure PMIN; andforming a diagnosis of any problems with the user's blowing technique based on said detected instantaneous volume V, flowrate F or pressure P values and providing at least a corrective coaching message to the user depending upon said diagnosis.21. The method of claim 1 , wherein the step of determining whether the instantaneous flowrate F status is greater than FMAX further comprises determining whether said status is endured for greater than a threshold period of time T.32. The method of claim 1 , wherein the step of determining whether the instantaneous flowrate F status is less than FMIN further ...

Device for collecting particles in an exhaled air flow

A device for collecting aerosol particles in an exhaled air flow. The particles may be aerosol particles such as biomarkers or particles related to drugs or other substances formed or found in the alveoli of the lungs. The device comprises an elongate housing with an inner wall and at least four first type partition walls extending substantially perpendicularly from opposite sides of the inner wall to partly cover the cross-section of the housing. The first type partition walls create a labyrinth shaped flow path to divert air flowing from the inlet towards the outlet of the housing in a direction towards opposite inner walls of the housing so that the particles separate from the air flow and attach on the device. The distance between two opposite first type partition walls is smaller than the transverse width of the housing and increases in the flow direction.

Pathogen sampling and testing

Devices and materials are disclosed for collecting breath samples and for testing such samples for the presence of a pathogen, for example the pathogen(s) associated with Coronavirus Disease 2019 (COVID-19). In some embodiments, a collection device can include a tube into which a subject can exhale or cough, and that provides for use of a filter to capture expired sample material. In some embodiments, a sample liquid can be created from the breath sample by addition of an indicator to render a pathogen in the sample readily detectable. In some embodiments, materials are provided for an assay to detect a pathogen in the sample liquid.

SKIN GAS MEASUREMENT DEVICE AND SKIN GAS MEASUREMENT METHOD

A skin gas measurement device includes a skin gas collecting unit that includes a skin gas collecting space having an opening that is to be attached to a skin surface, a porous material that is for adsorbing and concentrating a skin gas component that is emitted from the skin surface into the skin gas collecting space and that allows the adsorbed skin gas component to be desorbed at a relatively low temperature, and a heater for heating the porous material; and a skin gas measurement unit for measuring the skin gas component that is desorbed from the heated porous material. 1. A skin gas measurement device comprising:a skin gas collecting unit that includes a skin gas collecting space having an opening that is to be attached to a skin surface, a porous material that is for adsorbing and concentrating a skin gas component that is emitted from the skin surface into the skin gas collecting space and that allows the adsorbed skin gas component to be desorbed at a relatively low temperature, and a heater for heating the porous material; anda skin gas measurement unit for measuring the skin gas component that is desorbed from the heated porous material.2. The skin gas measurement device according to claim 1 ,wherein the porous material is hydrophobic.3. The skin gas measurement device according to claim 1 ,wherein a pore size of the porous material is larger than or equal to a molecular size of the skin gas component and less than or equal to three times the molecular size of the skin gas component.4. The skin gas measurement device according to claim 1 ,wherein the porous material is a zeolite.5. The skin gas measurement device according to claim 4 ,{'sub': 2', '2', '3, 'wherein a value of SiO/AlO[mol/mol] of the zeolite is greater than or equal to 10.'}6. The skin gas measurement device according to claim 1 ,wherein the skin gas component is acetone or a molecule having a molecular size that is equal to that of acetone.7. The skin gas measurement device according to ...

DEVICE FOR COLLECTING PARTICLES IN AN EXHALED AIR FLOW

The invention relates to a device for collecting aerosol particles in an exhaled air flow. Said particles may be aerosol particles such as biomarkers or particles related to drugs or other substances formed or found in the alveoli of the lungs. Said device comprises a housing having an extension direction between a first end with an inlet arranged to receive an exhaled air flow and a second end with an outlet arranged to transmit the exhaled air flow and an inner cross section defined by inner walls of the housing and at least four first type partition walls, arranged in a direction essentially perpendicular to the walls, partly covering the inner cross section of the housing. Said first type partition walls protrude from opposite sides of the inner wall of the housing creating opposite openings between the first type partition walls and the housing inner wall, whereby said first type partition walls are arranged to create a labyrinth shaped flow path from said inlet to said outlet which is arranged to divert the air flowing from the inlet towards the outlet in a direction towards opposite inner wall of the housing so that said particles separate from the air flow and attach on the device and wherein the distance between two opposite first type partition walls is smaller than the distance between the inner walls of the housing. 1. A device for collecting aerosol particles in an exhaled airflow , said device comprises:a housing having an extension length in a direction between a first end with an inlet arranged to receive an exhaled airflow and a second end with an outlet arranged to transmit the exhaled airflow, and an inner cross section defined by inner walls of the housing arranged at a distance from each other, andat least four first type partition walls, arranged at a distance from each other and extending in a direction essentially perpendicular to the walls, partly covering the inner cross section of the housing,wherein said first type partition walls ...

FLOW REGULATION DEVICE FOR BREATH ANALYSIS AND RELATED METHOD

A breath capture device for determining the concentration of acetone in a breath sample from a user. In some embodiments, the device includes a controller programmed to use stored data to control flow of a breath sample into an analysis chamber as the user exhales into a port. In other embodiments, the device includes a switch responsive to an action by the user that is operable between a first orientation in which breath entering the port preferentially travels through a second flow path and a second orientation in which breath entering the port preferentially travels through a first flow path. In still other embodiments, the device includes a flow regulator both responsive to user action and operable from a first position in which breath entering a port preferentially travels through a second flow path to a second position in which breath entering the port preferentially travels through a first flow path. 1. A breath capture device for determining the concentration of acetone in a breath sample from a user , comprising:an influent flow port;a first flow path coupled to the influent flow port, the first flow path comprising a chamber;a second flow path coupled to the influent flow port;an indicator responsive to a signal; anda switch configured to be responsive to an action by the user that is operable between a first orientation in which breath entering the influent port travels through the second flow path and a second orientation in which breath entering the influent port travels through the first flow path.2. The device of claim 1 , wherein the signal is generated by a sensor that measures a property of the breath sample of the user.3. The device of claim 1 , wherein the property of the breath sample of the user is a pressure.4. The device of claim 1 , wherein the signal is related to at least one of a flow rate and a volume.5. The device of claim 1 , wherein the signal is related to a duration of time.6. The device of claim 1 , wherein the property of the ...

Bi-Directional Motion Of A Lorentz-Force Actuated Needle-Free Injector (NFI)

The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body. 18-. (canceled)9. A method for delivering a drug through a tissue into a biological body , the method comprising:holding a fluid in a first chamber;holding the drug in a second chamber; andactivating plural electromagnetic actuators to (1) eject a portion of the fluid through a nozzle with sufficient pressure to penetrate the tissue of the biological body, the ejection creating a hole in the tissue, and (2) deliver the drug through the hole in the tissue and into the biological body.10. The method of claim 9 , further comprising activating the electromagnetic actuators to mix a remaining portion of the fluid with the drug prior to delivery of the drug.11. The method of claim 10 , wherein the electromagnetic actuators comprise bi-directional Lorentz-Force electromagnetic actuators.12. The method of claim 10 , wherein mixing the fluid with the drug involves oscillating contents of at least one of the first and second chambers to facilitate mixing of the fluid with the drug.13. The method of claim 9 , wherein the drug is a powdered drug.14. The method of claim 9 , wherein the drug is a therapeutic drug.15. The method of claim 9 , wherein the fluid is physiological saline.16. The method of claim 9 , further comprising aspirating the fluid into the first chamber.17. The method of claim 9 , further comprising monitoring the pressure with a pressure transducer.18. The method of claim 9 , wherein ...

METHOD AND APPARATUS FOR IDENTIFICATION OF BIOMARKERS IN BREATH AND METHODS OF USNG SAME FOR PREDICTION OF LUNG CANCER

The present invention provides a method for identifying biomarkers and generating an output indicative of disease. The method for identifying biomarkers comprises the steps of collecting a breath sample from subjects known to have a disease and subjects known to be free of the disease; analyzing the collected breath samples to determine all mass ions in each of the collected breath samples using at least one time-resolved separation technique and at least one mass-resolved separation technique; identifying a subset of the determined mass ions in a processor as the biomarkers for detecting the disease, the subset of the determined mass ions are statistically significant for detecting the disease; and combining the subset of the determined mass ions in a multivariate algorithm in the processor to generate a value of a discriminant function indicating the likelihood that the subject has the disease. 1. A method for identifying a plurality of biomarkers for predicting disease in a subject which comprises the steps of:a. collecting a breath sample from subjects known to have a disease and subjects known to be free of the disease;b. analyzing the collected breath samples to determine all mass ions in each of the collected breath samples using at least one time resolved separation technique and at least one mass resolved separation technique;c. identifying a subset of the determined mass ions in a processor as the biomarkers for detecting disease, the subset of the determined mass ions are statistically significant for detecting the disease; andd. combining the subset of the determined mass ions in a multivariate algorithm in a processor to generate a discriminant function,wherein the discriminant function indicates a value of the likelihood that the subject has the disease.2. The method of wherein the subjects are human.3. The method of wherein the disease is breast cancer.4. The method of wherein the at least one time resolved separation technique is gas chromatography.5 ...

Sobriety monitoring system

A system and method of monitoring sobriety using a hand-held breath testing device that, on receipt of a user's breath, generates a breath test signal comprising substance content data and user identification data, and wirelessly transmits the breath test signal to a breath test signal receiving station.

ELECTRONIC DEVICE FOR PROVIDING HEALTH INFORMATION AND OPERATION METHOD THEREOF

An electronic device and method are disclosed herein. The electronic device includes a sensor, and a processor. The processor may implement the method, including acquiring, by the sensor, first biometric information of a user, determining alcohol information for determining a presence of of alcohol in the user from the first biometric information, determining second biometric information of the user related to the alcohol information, and generating health information to be displayed the user or transmitted to another electronic device based on the second biometric information. 1. An electronic device comprising:a sensor; anda processor configured to:acquire, by the sensor, first biometric information of a user,determine alcohol information for determining a presence of of alcohol in the user from the first biometric information,determine second biometric information of the user related to the alcohol information, andgenerate health information to be displayed to the user or transmitted to another electronic device based on the second biometric information.2. The electronic device of claim 1 , wherein the processor the first biometric information is acquired by the sensor in response to detecting occurrence of at least one preset function.3. The electronic device of claim 2 , wherein the processor is configured to acquire the first biometric information during a time range beginning from a first time point indicating a beginning of the occurrence of the at least one of the preset functions to a second time point indicating an end of the occurrence of the least one function.4. The electronic device of claim 1 , wherein the first biometric information is acquired when at least one of a tear claim 1 , a droplet of sweat and an exhalation of the user contact the sensor.5. The electronic device of claim 1 , wherein the health information is generated in response to detecting that at least one value of the second biometric information is disposed within a predetermined ...

BREATH ACETONE MONITOR AND METHOD OF DETECTING BREATH ACETONE

A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement. The receiver is configured to receive a breath sample from a user. The first plurality of layers and second plurality of layers being configured to interact in response to the level of acetone in the breath sample. The breath acetone meter further including a light source arranged to emit a light onto the receiver. A sensor is arranged to receive the light and output a voltage in response to receiving the light, wherein the voltage is proportional to an amount of acetone in the breath sample. 1. A method of measuring breath acetone , the method comprising:receiving a sample of a user's breath with a meter device, the meter device having a receiver comprising a first polymer layer and a second polymer layer, the meter device further having a light source and a sensor;interacting the first polymer layer with the second polymer layer to change a light absorption level of the receiver in response to receiving the patient's breath;emitting a light from the light source onto the receiver;receiving the light on the sensor;generating a voltage with the sensor; anddetermining an amount of acetone based at least in part on the voltage.2. The method of wherein:the first polymer layer and the second polymer layer are each formed from a plurality of layers; andthe step of interacting the first plurality of layers with the second plurality of layers includes cross-linking the first polymer layer and the second polymer layer.3. The method of further comprising determining a physiological parameter based at least in part on the determined amount of acetone.4. The method of wherein the determined physiological parameter is a blood sugar level.5. The method of further comprising disposing the first plurality of layers and the second plurality of layers in an alternating arrangement.6. The method of wherein ...

Delivering and/or receiving fluids

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

COMBINATION NON-INVASIVE AND INVASIVE BIOPARAMETER MEASURING DEVICE

In a combination invasive and non-invasive bioparameter monitoring device an invasive component measures the bioparameter and transmits the reading to the non-invasive component. The non-invasive component generates a bioparametric reading upon insertion by the patient of a body part. A digital processor processes a series over time of digital color images of the body part and represents the digital images as a signal over time that is converted to a learning vector using mathematical functions. A learning matrix is created. A coefficient of learning vector is deduced. From a new vector from non-invasive measurements, a new matrix of same size and structure is created. Using the coefficient of learning vector, a recognition matrix may be tested to measure the bioparameter non-invasively. The learning matrix may be expanded and kept regular. After a device is calibrated to the individual patient, universal calibration can be generated from sending data over the Internet. 1. A method of monitoring a bioparameter , comprising:(a) invasively measuring the bioparameter of a patient using an invasive component of a bioparameter monitoring device, transmitting an invasive bioparameter reading to a non-invasive component of the bioparameter monitoring device and storing the invasive bioparameter reading in the non-invasive component;(b) within a proximity time of step “(a)”, one or more variable sensors in the non-invasive component of the device generating a series of data about tissue of a body part of the patient, sensing a magnitude of a sensed variable at each variable sensor, and converting the magnitudes into a series of electric signals, the signal representing a non-invasive measurement of the bioparameter of the patient;(c) one or more processors of the non-invasive component programmed to convert the signal to a scalar learning number (i) using a mathematical function to convert the signal to a scalar learning number and (ii) repeating step “(c)(i)”, without ...

Recovering analytes by reverse plasmaporation

A subject's skin is exposed to non-thermal plasma, thereby enabling analytes in the interstitial fluid in the subject's body to migrate to the surface of the subject's skin. The concentration of analytes in the subject's blood can be determined based on the amount of these analytes.

PORTABLE FLUID SAMPLING DEVICE, SYSTEM FOR USING SAME, AND METHOD OF MAKING AND USING SAME

A system for collecting and retaining a sample from exhaled breath of a subject for analysis can include a two part housing, a two part trap section, and optionally a boat fitment. Disclosed is a portable fluid sampling device comprising: a housing including a first portion removably attachable to a second portion, the first and second portions being configured to combine to form a chamber therein, the chamber being configured to at least temporarily contain or hold a biological sample therein, at least one of the first portion and the second portion including an inlet, the other of the first portion and the second portion including an outlet, wherein the device further comprises at least one of the following: a) one of the first portion and the second portion including an end having a projection, the other of the first portion and the second portion including an end having a groove, the groove being configured to receive at least a portion of the projection therein; or b) tamper evident means for indicating that the first portion of the housing has previously been separated from the second portion of the housing. 1. A portable fluid sampling device comprising:a housing including a first portion removably attachable to a second portion, the first and second portions being configured to combine to form a chamber therein, the chamber being configured to at least temporarily contain or hold a biological sample therein, at least one of the first portion and the second portion including an inlet, the other of the first portion and the second portion including an outlet,wherein the device further comprises:a) one of the first portion and the second portion including an end having a projection, the other of the first portion and the second portion including an end having a groove, the groove being configured to receive at least a portion of the projection therein; andb) a heat stamped symbol on an exterior of each of the first and second portions of the housing, the heat ...

HEALTH TEST FOR A BROAD SPECTRUM OF HEALTH PROBLEMS

Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder. 1. A method of processing a salivary cell sample for biomarker analysis comprising:(a) applying a sample of saliva or salivary cells from a subject to a substrate;(b) fixing the cells;(c) incubating the cells in low pH citrate buffer at 37° C.;(d) contacting the cells with serum;(e) applying a primary antibody for each of biomarker of a biomarker panel; and(f) detecting the binding of the primary antibody using a secondary antibody having a detectable label, wherein the label is detected optically using a computerized image analysis.2. The method of claim 1 , wherein the biomarker panel comprises at least one biomarker selected from the group consisting of Acidic Trehalase-like protein 1 (ATHL) claim 1 , Adrenocorticotropic hormone (ACTH) claim 1 , Aldose Reductase (ALR) claim 1 , ALG-2 interacting protein X (Alix) claim 1 , Annexin 5 (Annex) claim 1 , Apolipoprotein B mRNA editing enzyme APOBEC 3G (APO) claim 1 , Aquaporin 5 (AQPS) claim 1 , Betaine-GABA transporter 1 (BGT) claim 1 , Bone Marrow Stromal Cell Antigen 2 (BST2 claim 1 , Tetherin) claim 1 , Caspase 3 (Casp3) claim 1 , Caspase 8 (Casp8) claim 1 , CD63 (CD63 claim 1 , Tetraspanin claim 1 , LAMP-3) claim 1 , CD9 claim 1 , Cyclin D1 (Cyclin) claim 1 , Cyclooxygenase-2 (Cox-2) claim 1 , Cytochrome P450 2E1 (CYP450) claim 1 , Cytochrome P450 Reductase (CYPOR) claim 1 , Human beta defensing 2 (HBD2 claim 1 ,) Human beta defensin 3 (HBD3) claim 1 , Human beta defensin 4 (HBD4) claim 1 , DICER claim 1 , Epidermal growth factor receptor (EGFR) claim 1 , Ferritin (Fer) claim 1 , Fos (Fos) claim 1 , Furin convertase (Furin claim 1 , PACE) claim 1 , Glucocorticoid receptor (GR) claim 1 , Glucose regulated protein 58 (Grp58) claim 1 , Glucose regulated ...

BLOOD GLUCOSE DETECTION DEVICE

A blood glucose detection device includes a carrier body, a flow-guiding actuator, a microneedle patch, a sensor and a controlling chip. The carrier body has a liquid guiding channel, a compressing chamber and a liquid storage chamber. The flow-guiding actuator seals the compressing chamber. The microneedle patch is attached on the carrier body and has plural hollow microneedles. The sensor is disposed within the liquid storage chamber. The controlling chip is disposed on the carrier body. The plural hollow microneedles puncture the skin of a human subject with minimal invasion. The controlling chip controls the flow-guiding actuator to actuate and the tissue fluid is sucked into the liquid storage chamber through the plural hollow microneedles, whereby the sensor detects the blood glucose of the tissue fluid to generate and transmit the measured data to the controlling chip. The controlling chip can generate monitoring information by calculating the measured data. 1. A blood glucose detection device , comprising:a carrier body having a liquid guiding channel, a compressing chamber and a liquid storage chamber, wherein the liquid guiding channel includes an inlet channel and a liquid storage channel separately disposed on the carrier body, the compressing chamber is in fluid communication with the inlet channel and the liquid storage channel, and the liquid storage channel is in fluid communication with the liquid storage chamber;a flow-guiding actuator constructed on the carrier body and sealing the compressing chamber;a microneedle patch attached on the carrier body and being in fluid communication with the inlet channel, wherein the microneedle patch has plural hollow microneedles adapted to puncture skin of a human subject with minimal invasion so as to suck a tissue fluid of the human subject;a sensor systematic packaged on the carrier body and disposed within the liquid storage chamber, wherein the sensor measures a blood glucose level of the tissue fluid and ...

SYSTEMS AND METHODS FOR EVALUATING INTERSTITIAL FLUIDS

A transdermal sampling system includes a microfluidic assembly for retrieving and transferring at least one biomarker transdermally from the skin of a subject. The biomarker is selected from a group of biomarkers consisting of: a nicotine biomarker, β-hCG, luteinizing hormones, ESAT6; CFP10, Hsp16.3, marijuana and its derivatives, opiates, narcotics, ethanol, barbiturates, pyridinoline crosslinks, Calcitonin, FSH, estrogen, vitamin D, calcium, glial fibrillary acid protein (GFAP), microtubule-associated protein tau, SNTF-calpain cleaved N terminal fragment proteins, estradiol, P4-progesterone, troponin, lactate, COlevels, and pH levels. A transdermal detector identifies and quantifies the at least one biomarker. 1. A transdermal sampling system , comprising: 'a nicotine biomarker, β-hCG, luteinizing hormones, ESAT6; CFP10, Hsp16.3,', 'a microfluidic assembly for retrieving and transferring at least one biomarker transdermally from the skin of a subject, wherein the biomarker is selected from a group of biomarkers consisting of{'sub': '2', 'marijuana and its derivatives, opiates, narcotics, ethanol, barbiturates, pyridinoline crosslinks, Calcitonin, FSH, estrogen, vitamin D, calcium, glial fibrillary acid protein (GFAP), microtubule-associated protein tau, SNTF-calpain cleaved N terminal fragment proteins, estradiol, P4-progesterone, troponin, lactate, COlevels, and pH levels; and'}a transdermal detector for identifying and quantifying the at least one biomarker.2. A transdermal sampling system , comprising a microfluidic assembly in the form of a patch as recited in the description. This application claims benefit of priority to U.S. Provisional Patent Application No. 62/589,703 filed Nov. 22, 2017, which is incorporated by reference herein in its entirety.The present invention relates to the field of portable biomedical and bio-molecular monitoring, remote diagnostics and connected healthcare. More specifically, the present invention relates to a method, apparatus, ...

BREATH SAMPLE SYSTEMS FOR USE WITH VENTILATORS

Breath sample systems for use with ventilators are disclosed herein. An example device can include a housing that contains a breath capture module that collects a breath sample from a patient, an input in fluid communication with an expiratory limb of a ventilator and the breath capture module, the input receiving a breath of the patient, an output in fluid communication with the expiratory limb of a ventilator to return the breath to the ventilator, a pump, and a controller that controls the pump to obtain the breath sample by drawing the breath into the input, across the breath capture module, and out of the output. 1. A device for use with a ventilator , the device comprising:a housing comprising a breath capture module that collects a breath sample from a patient;an input in fluid communication with an expiratory limb of a ventilator and the breath capture module, the input receiving a breath of the patient;an output in fluid communication with the expiratory limb of a ventilator to return the breath to the ventilator;a pump; anda controller comprising a processor and memory for storing instructions, the processor executing the instructions to control the pump to obtain the breath sample by drawing the breath into the input, across the breath capture module, and out of the output.2. The device according to claim 1 , further comprising a first conduit that couples the expiratory limb to the input claim 1 , and a second conduit that couples the output to the expiratory limb at a location that is proximate to the ventilator and downstream from the first conduit.3. The device according to claim 2 , wherein the first conduit is coupled with a fitting that is installed inline on the expiratory limb.4. The device according to claim 1 , wherein the processor is configured to obtain a predetermined number of breath samples claim 1 , the predetermined number of breath samples being based on a flowrate or a periodicity of the breath.5. The device according to claim 1 , ...

Attachment Device and Method for a Sample Collection Device for Obtaining Samples from Respiratory Air

An attachment device for a sample collection device for obtaining samples from exhaled respiratory air includes an inlet tube, a dip tube for discharging the respiratory air from the sample collection device, and at least a portion of a spiral path. The portion runs into an outlet opening which is designed to conduct the respiratory air to the sample collection device. 1. An attachment device for a sample collection device configured for obtaining samples from exhaled respiratory air , the attachment device comprising:an inlet tube;a dip tube configured to discharge the respiratory air from the sample collection device;an outlet opening configured to conduct the respiratory air to the sample collection device; andat least a portion of a spiral path, the portion running into the outlet opening.2. The attachment device as claimed in claim 1 , wherein the inlet tube has an interface for fastening a mouthpiece.3. The attachment device as claimed in claim 1 , wherein the inlet tube is configured as a mouthpiece.4. The attachment device as claimed in claim 1 , wherein the dip tube has a protrusion that protrudes beyond a stop of the attachment device for the sample collection device.5. The attachment device as claimed in claim 1 , further comprising:an interface configured for mechanical, reversible connection of the attachment device and the sample collection device.6. A collector comprising:a sample collection device; and an inlet tube;', 'a dip tube configured to discharge respiratory air from the sample collection device;', 'an outlet opening configured to conduct the respiratory air to the sample collection device; and', 'at least a portion of a spiral path, the portion running into the outlet opening., 'an attachment device coupled mechanically to the sample collection device, the attachment device comprising7. The collector as claimed in claim 6 , wherein the attachment device tapers at a side directed toward the sample collection device and has an opening claim 6 ...

SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE COLLECTION

Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container. 169-. (canceled)70. A method comprising:collecting a sample into at least one sample collection channel of a sample collection device via a first type of motive force;after a desired amount of sample fluid has been confirmed to be in the sample collection channel, establishing fluid communication between the sample collection channel and a sample container of the sample collection device, whereupon the container uses a second motive force different from the first motive force used to collect the sample to move bodily fluid sample from the sample collection channel into the sample container;wherein the sample container has gas permeable and penetration re-sealable enclosure.71. The method of claim 70 , wherein an interior of one of the sample collection channel is coated with an anticoagulant.72. The method of claim 71 , wherein the anticoagulant is citrate.73. The method of claim 71 , wherein the anticoagulant is heparin.74. The method of claim 71 , wherein the anticoagulant is ethylenediaminetetraacetic acid (EDTA).75. The method of wherein the second motive force comprises a suction force.76. The method of further comprising mixing the bodily fluid sample with the anticoagulant coating prior to the sample entering the sample ...

BLOOD ANALYTE COLLECTION DEVICE AND METHODS OF USE THEREOF

Provided is a blood analyte collection device that includes a microneedle array configured to provide fluid communication between a cellular interstitial fluid of a subject and a collection device fluid, a device chamber containing the collection device fluid, and a sequestration material in the device chamber configured to bind to a blood analyte from the cellular interstitial fluid. Also provided are methods and kits that use the subject blood analyte collection device. The subject devices, methods and kits find use in a variety of applications, such as detecting a blood analyte, such as glucose, in a subject. 1. A blood analyte collection device comprising:(a) a microneedle array configured to provide fluid communication between a cellular interstitial fluid of a subject and a collection device fluid;(b) a device chamber containing the collection device fluid; and(c) a sequestration material in the device chamber configured to bind to a blood analyte from the cellular interstitial fluid.2. The blood analyte collection device of claim 1 , wherein the blood analyte is selected from the group consisting of sodium claim 1 , potassium claim 1 , urea claim 1 , creatinine claim 1 , glucose claim 1 , HbA1C claim 1 , chloride claim 1 , calcium claim 1 , ammonia claim 1 , copper claim 1 , phosphate claim 1 , inorganic phosphorus claim 1 , copper claim 1 , zinc claim 1 , magnesium claim 1 , vitamin A claim 1 , vitamin B claim 1 , vitamin B claim 1 , vitamin C claim 1 , homocysteine claim 1 , vitamin E claim 1 , vitamin D claim 1 , lead claim 1 , ethanol claim 1 , recreational drugs claim 1 , lactate dehydrogenase claim 1 , amylase claim 1 , lipase claim 1 , angiotensin-converting enzyme claim 1 , acid phosphatase claim 1 , eosinophil cationic protein claim 1 , and a micronutrient claim 1 , or mixtures thereof.3. The blood analyte collection device of claim 1 , wherein the cellular interstitial fluid is present in the epidermis of the subject.4. The blood analyte collection ...

BREATH ACETONE MEASUREMENT SYSTEM WITH PORTABLE BASE UNIT THAT COMMUNICATES WITH MOBILE APPLICATION

A portable system is provided for measuring a ketone, such as an acetone, in the breath or other bodily fluid of a user. The system includes a portable measurement device that analyzes fluid samples and generates corresponding ketone measurements. The portable measurement device communicates with an application which runs on a smartphone or other mobile device of the user. The application tracks, and generates graphs of, the ketone measurements, and may include various features for facilitating the analysis of the measurements. 120-. (canceled)21. A system for measuring ketone levels in breath , the system comprising:a disposable cartridge configured to receive a breath sample and to react to a ketone in the breath sample;a base unit configured to analyze the disposable cartridge after the disposable cartridge receives the breath sample, and to generate a ketone measurement based on the analysis of the disposable cartridge, the base unit comprising a wireless transceiver capable of transmitting the ketone measurement to mobile communications device; and receive the ketone measurement via a wireless communications link between the base unit and the mobile communications device;', 'display a user interface that includes a set of tags, each tag representing a respective condition that can affect ketone measurements, each tag individually selectable via the user interface to tag the ketone measurement with information that enables masking effects of the conditions to be considered during subsequent analysis of ketone measurements;', 'receive, via the user interface, and in association with the ketone measurement, a user selection of a tag; and', 'record the selection of the tag in association with the ketone measurement;, 'a mobile application stored in computer storage, the mobile application comprising executable instructions that direct the mobile communications device to at leastwherein the mobile application is configured to segregate ketone measurements received ...

BIOSPECIMEN EXTRACTION APPARATUS

Needle-less extraction of a biospecimen from tissue having a number of tissue layers including an epidermis layer includes creating a first port through a target surface and into an underlying one of the tissue layers, creating a second port through the target surface and into the underlying one of tissue layers, providing an injectate through the first port to the underlying one of the tissue layers underlying the epidermis layer, and extracting at least a portion of the injectate and the biospecimen from the underlying one of the layers through the second port. 1. A method for needle-less extraction of a biospecimen from tissue having a plurality of tissue layers including an epidermis layer , the method comprising:creating a first port through a target surface and into an underlying one of the plurality of tissue layers;creating a second port through the target surface and into the underlying one of plurality of tissue layers;providing an injectate through the first port to the underlying one of the plurality of tissue layers underlying the epidermis layer; andextracting at least a portion of the injectate and the biospecimen from the underlying one of the layers through the second port.2. The method of wherein creating the first port and creating the second port occurs substantially simultaneously.3. The method of wherein creating the first port is at a first depth relative to a surface of the epidermis and creating the second port is at a second depth relative to the surface of the epidermis.4. The method of wherein the first depth and second depth are substantially the same.5. The method of wherein creating the first port at a first angle relative to the target surface and creating the second port at a second angle relative to the target surface.6. The method of wherein the plurality of the tissue layers includes a dermis layer and a subcutaneous layer underlying the epidermis layer.7. The method of wherein the underlying one of the plurality of tissue layers ...

METHOD AND TOOL SET FOR COLLECTING BODY FLUID OF A PERSON TO BE EXAMINED

A method for collecting a body fluid sample of a person to be examined is provided. The method comprises steps of: providing a body fluid sample collecting device and a body fluid sample inspection device for collecting the body fluid sample according to a test sampling requirement, wherein the body fluid sample collecting device includes a body fluid sample collecting region having an open hydrophilic layer with a specific layer area, and configured for collecting a predetermined amount of the body fluid sample; from a body surface of the person to be examined, causing the body fluid sample to be collected onto the body fluid sample collecting region until the body fluid sample covers the hydrophilic layer completely; and receiving the body fluid sample from the body fluid collecting region to be inspected in the body fluid sample inspection device. 1. A method for collecting a body fluid sample of a person to be examined , comprising steps of:providing a body fluid sample collecting device and a body fluid sample inspection device for collecting the body fluid sample according to a test sampling requirement, wherein the body fluid sample collecting device includes a body fluid sample collecting region having an open hydrophilic layer with a specific layer area, and configured for collecting a predetermined amount of the body fluid sample;from a body surface of the person to be examined, causing the body fluid sample to be collected onto the body fluid sample collecting region until the body fluid sample covers the hydrophilic layer completely; andreceiving the body fluid sample from the body fluid collecting region to be inspected in the body fluid sample inspection device or to be preserved.2. The method according to claim 1 , wherein the body fluid sample inspection device includes a sampling inlet and a microfluidic portion connected to the sampling inlet claim 1 , a reagent is disposed on the microfluidic portion claim 1 , and the method further comprising ...

RESPIRABLE AND THORACIC SAMPLING INLET ASSEMBLIES

A portable sampler, the sampler including a sampler assembly having a housing that includes a receiver defined therein for interchangeably receiving a number of removable inlet assemblies, the removable inlet assemblies including a respirable inlet assembly and a thoracic inlet assembly. The respirable inlet assembly includes a hybrid cyclone assembly, the hybrid cyclone assembly including an impaction stage and a cyclone in series. The thoracic inlet assembly includes an inlet slot configured to function as a size-selective inlet. Another thoracic inlet assembly includes a housing having a number of openings configured to receive a sample airflow; an inlet insert through which an inlet aperture is defined; a prequalification chamber defined between a lower surface of the housing and an upper surface of the inlet insert; and a protrusion extending downward from the lower surface of the housing into the inlet aperture of the inlet insert to from an inlet slot. 1. A respirable inlet assembly for a portable sampling device , comprising:an upper housing and a lower housing;a number of primary inlet apertures disposed in the upper housing configured to receive a sample airflow; anda hybrid cyclone assembly comprising an impaction stage and a cyclone stage in series.2. The respirable inlet assembly of claim 1 , wherein only a part of the sample airflow passes through the impaction stage.3. The respirable inlet assembly of claim 2 , wherein all of the sample airflow passes through the cyclone stage.4. The respirable inlet assembly of claim 1 , wherein the hybrid cyclone assembly further comprises:a number of impactor inlet apertures configured to receive a first part of the sample airflow into the impaction stage from the number of primary inlet apertures; anda number of impactor bypass apertures configured to receive a second part of the sample airflow.5. The respirable inlet assembly of claim 4 , wherein the number of impactor bypass apertures is configured to reduce an ...

HYDROGEL-ENABLED MICROFLUIDIC SWEAT SEQUESTERING FOR WEARABLE HUMAN-DEVICE INTERFACES

Microfluidic devices are provided for continuous sampling of biological fluid for extended periods of time, e.g. for periods of time up to and including 10 days. The microfluidic devices can be made from porous hydrophilic substrate, e.g. hydrophilic paper substrates. The devices can include a collection pad, an evaporative pump, and a channel connecting the collection pad and the evaporative pump. Hydrogels at the collection pad can promote collection of sweat or other biological fluids from a subject, which in some aspects is assisted by the use of one or more microneedles on the substrate. An evaporative pump can provide for long periods of sampling by providing continual pumping, e.g. through the use of an evaporation pad where sampled fluid can evaporate. 1. A microfluidic device comprising:a porous hydrophilic substrate having both an upper surface and a lower surface, the porous hydrophilic substrate comprising a collection pad, an evaporative pump, and a channel connecting the collection pad and the evaporative pump; anda hydrogel in contact with the surface of the porous hydrophilic substrate at the collection pad, wherein the hydrogel comprises a plurality of extractants.2. The microfluidic device according to claim 1 , wherein the porous hydrophilic substrate comprises a cellulosic substrate.3. The microfluidic device according to claim 1 , wherein the cellulosic substrate is selected from the group consisting of paper claim 1 , cellulose derivatives claim 1 , woven cellulosic materials claim 1 , and non-woven cellulosic materials.4. The microfluidic device according to claim 3 , wherein the paper is selected from the group consisting of filter paper claim 3 , chromatography paper claim 3 , card stock claim 3 , vellum paper claim 3 , printing paper claim 3 , bond paper claim 3 , blotting paper claim 3 , drawing paper claim 3 , tissue paper claim 3 , paper towel claim 3 , and nanocelluosic paper.5. The microfluidic device according to claim 3 , wherein the ...

Method and apparatus for analyzing acetone in breath

Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level. The method also comprises using the breath analysis device to detect the change in the optical characteristic to sense the acetone in the breath. Apparatuses that use these methods are also described.

SYSTEM AND METHOD FOR IN OVO SEXING OF AVIAN EMBRYOS

A system for determining the gender and/or fertility status of avian eggs including a sampling apparatus and an electromagnetic radiation transmitter and detector. In certain embodiments, the transmitter operates in the terahertz range. The sampling apparatus can be coupled to an avian egg. The sampling apparatus includes a vacuum source, a gas collection device, and a membrane that can be positioned in the passageway coupling the vacuum source to the gas collection device. The membrane is capable of capturing volatile organic compounds. The sampling apparatus applies a vacuum from the vacuum source to the gas proximate to the avian egg and directs the gas captured from the vicinity of the egg toward the membrane. Subsequently, the membrane is positioned within the electromagnetic radiation emitted by the transmitter, generating a spectrum which can be analyzed to determine whether the egg is fertile or infertile, and if fertile, whether the egg is male or female. In an embodiment, the captured volatile organic compounds are transferred to a sample chamber where the captured gas is analyzed. 1. A system for determining the gender and/or fertility status of avian eggs comprising:a sampling apparatus coupleable, during use, to the avian egg, wherein the sampling apparatus comprises a vacuum source, a gas collection device coupled to the vacuum source and a membrane positioned in the passageway coupling the vacuum source to the gas collection device, wherein the membrane is capable of capturing volatile organic compounds, wherein the sampling apparatus applies a vacuum from the vacuum source to the gas proximate to the avian egg and directs the gas captured from the vicinity of the egg toward the membrane; andan electromagnetic radiation transmitter and detector, wherein the membrane is positionable within the electromagnetic radiation emitted by the transmitter.2. The system of claim 1 , wherein the electromagnetic radiation is in the terahertz frequency range.3. The ...

SYSTEM AND METHOD FOR IN OVO SEXING OF AVIAN EMBRYOS

A system for determining the gender and/or fertility status of avian eggs including a sampling apparatus and an electromagnetic radiation transmitter and detector. In certain embodiments, the transmitter operates in the terahertz range. The sampling apparatus can be coupled to an avian egg. The sampling apparatus includes a vacuum source, a gas collection device, and a membrane that can be positioned in the passageway coupling the vacuum source to the gas collection device. The membrane is capable of capturing volatile organic compounds. The sampling apparatus applies a vacuum from the vacuum source to the gas proximate to the avian egg and directs the gas captured from the vicinity of the egg toward the membrane. Subsequently, the membrane is positioned within the electromagnetic radiation emitted by the transmitter, generating a spectrum which can be analyzed to determine whether the egg is fertile or infertile, and if fertile, whether the egg is male or female. In an embodiment, the captured volatile organic compounds are 154-. (canceled)55. A system for determining the gender and/or fertility status of avian eggs comprising:one or more carriers for receiving one or more avian eggs;one or more transmitters capable of emitting preselected electromagnetic radiation, wherein the one or more transmitters direct the preselected electromagnetic radiation into the one or more avian eggs; andone or more detectors capable of detecting the preselected electromagnetic radiation that passes through the one or more avian eggs.56. The system of claim 55 , wherein the electromagnetic radiation is in the terahertz frequency range.57. The system of claim 55 , wherein the carrier is incorporated into an egg handling apparatus.58. The system of claim 57 , wherein the egg handling apparatus comprises at least one transmitter and at least one detector claim 57 , wherein each of the at least one transmitter and at least one detector are capable of substantially simultaneously ...

SYSTEM AND METHOD FOR IN OVO SEXING OF AVIAN EMBRYOS

A system for determining the gender and/or fertility status of avian eggs including a sampling apparatus and an electromagnetic radiation transmitter and detector. In certain embodiments, the transmitter operates in the terahertz range. The sampling apparatus can be coupled to an avian egg. The sampling apparatus includes a vacuum source, a gas collection device, and a membrane that can be positioned in the passageway coupling the vacuum source to the gas collection device. The membrane is capable of capturing volatile organic compounds. The sampling apparatus applies a vacuum from the vacuum source to the gas proximate to the avian egg and directs the gas captured from the vicinity of the egg toward the membrane. Subsequently, the membrane is positioned within the electromagnetic radiation emitted by the transmitter, generating a spectrum which can be analyzed to determine whether the egg is fertile or infertile, and if fertile, whether the egg is male or female. In an embodiment, the captured volatile organic compounds are transferred to a sample chamber where the captured gas is analyzed. 154-. (canceled)55. A method of measuring characteristics of eggs , comprising:placing a plurality of eggs in a holder;collecting gases emitted from each of two or more of the eggs;measuring one or more characteristics of the collected gas; anddetermining one or more characteristics of each of at least two of the eggs based on the measurements of the gas.56. The method of claim 55 , wherein said step of collecting gases emitted from each of two or more of the eggs is provided by means of vacuum claim 55 , a gas collection device claim 55 , and a membrane capable of capturing gas.57. The method of claim 55 , wherein said step of determining additionally comprising steps of applying electromagnetic radiation to the membrane claim 55 , wherein the electromagnetic radiation is preselected to allow the quantity of one or more volatile organic compounds captured in the membrane to be ...

RECTUM GAS PASSAGE ANALYZER

The various embodiments herein provide a device for analysing a rectum gas discharge. The device comprises a central bag, a peripheral bag, and an electronic unit. The central bag comprises a gas inlet and a gas outlet on directionally opposite ends of a central bag surface. The peripheral bag is housed in a container and radially encapsulates the central bag. The electronic unit comprises a pressure sensor and a connector for further connecting a monitoring unit. The pressure sensor is attached over a surface of the peripheral bag. The central bag is attached to an anal canal of a patient and expands on ingestion of discharged rectal gas from the anal canal. The peripheral bag expands with the central bag resulting in activation of the pressure sensor to measure a gas collected in the central bag. 1. A device for analysing a rectum gas discharge comprising:a central bag, wherein the central bag comprises a gas inlet and a gas outlet on directionally opposite ends of a central bag surface;a peripheral bag, wherein the peripheral bag is housed in a container and radially encapsulates the central bag;an electronic unit, wherein the electronic unit comprises a pressure sensor and a connector for further connecting a monitoring unit, wherein the pressure sensor is attached over a surface of the peripheral bag;wherein, the central bag is attached to an anal canal of a patient and expands on ingestion of discharged rectal gas from the anal canal, wherein the peripheral bag expands with the central bag resulting in activation of the pressure sensor to measure a gas collected in the central bag.2. The device according to claim 1 , wherein the pressure sensor is connected to the monitoring unit through the connector claim 1 , wherein the monitoring unit comprises a user interactive display claim 1 , a central processing unit claim 1 , a communication unit claim 1 , and a memory unit.3. The device according to claim 1 , wherein the gas enters the central bag through the gas ...

BREATH KETONE MEASUREMENT SYSTEM CAPABLE OF DETECTING KETONE MEASUREMENT PATTERNS ASSOCIATED WITH PROGRAM NON-COMPLIANCE EVENTS

A portable system is provided for measuring a ketone, such as an acetone, in the breath or other bodily fluid of a user. The system includes a portable measurement device that analyzes fluid samples and generates corresponding ketone measurements. The portable measurement device communicates with an application which runs on a smartphone or other mobile device of the user. The application tracks, and generates graphs of, the ketone measurements, and may include various features for facilitating the analysis of the measurements. 1. A system for measuring and monitoring ketone levels in a human , comprising:a disposable cartridge configured to receive a breath sample and to react to a ketone in the breath sample;a base unit configured to analyze the disposable cartridge after the disposable cartridge receives the breath sample, and to generate a ketone measurement based on the analysis of the disposable cartridge, the base unit comprising a wireless transceiver capable of transmitting the ketone measurement to a separate device; and receiving a sequence of ketone measurements generated by the base unit from respective breath samples of a user;', 'determining whether the sequence of ketone measurements corresponds to a user behavior associated with non-compliance with a behavioral program, wherein determining whether the sequence corresponds to the user behavior comprises comparing the sequence to a ketone pattern associated with the user behavior; and', 'in response to determining that the sequence corresponds to the user behavior, generating a notification of a possible occurrence of the user behavior., 'a non-transitory storage medium having stored thereon program instructions that direct a computing system comprising one or more computing devices to perform a process that comprises2. The system of claim 1 , wherein the program instructions instruct a mobile device of the user to generate a user interface that prompts the user to indicate whether the user behavior ...