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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 13037. Отображено 100.
05-01-2012 дата публикации

Light imaging apparatus, system and method

Номер: US20120002101A1
Принадлежит: BIOSPACE LAB

The imaging apparatus comprises a light-tight enclosure in which are enclosed: a detector adapted to detect a light signal emitted from a sample, a reflecting device comprising first and second reflecting portions reflecting toward first and second portions of the detector a signal emitted from first and second portions of the sample, the second reflecting portion reflecting toward a third portion of the detector a signal emitted from a the third portion of the sample and previously reflected by the first reflecting portion, a fourth portion of the detector directly detecting a signal emitted from a fourth portion of the sample.

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12-08-2021 дата публикации

Устройство визуализации поверхностных вен

Номер: RU0000205830U1

Настоящая полезная модель относится к медицинской технике и медицинскому оборудованию, а именно к неинвазивному портативному устройству для визуализации подкожных вен с использованием источников света в видимом световом диапазоне. Предлагаемое устройство может быть использовано для неинвазивной визуализации периферийных подкожных вен при проведении таких венозных манипуляций, как: введение внутривенных инъекций, забор крови из вены, установка внутривенных катетеров, проведение склеротерапии.Сущность полезной модели заключается в том, что визуализатор вен состоящий из корпуса в форме рукояти для хвата, двух элементов крепления печатной платы управления, проводного соединения, аккумуляторной батареи, коммутационного элемента, оптической линзы и крышки, имеет в своем составе печатную плату со светодиодами и токоограничивающими резисторами, изготовленную из алюминия. Использование алюминия позволяет предотвратить повышение температуры рабочей поверхности устройства свыше 46°С за счет отведения тепла от светодиодов, а также позволяет предотвратить перегрев светодиодов. Корпус имеет рабочую область подсветки в форме разомкнутого овала с прорезью 10-16 мм для проведения внутривенных инъекций, установки катетеров или забора крови. Светодиоды находятся в параллельном включении, каждый светодиод последовательно соединен с токоограничивающим резистором, что позволяет сформировать пороговое напряжение для каждого светодиода, которое не будет зависеть от пороговых напряжений других светодиодов в цепи, а также позволяет ограничить рабочий ток каждого светодиода. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 205 830 U1 (51) МПК A61B 5/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК A61B 5/0059 (2021.05); A61B 5/0077 (2021.05); A61B 5/489 (2021.05) (21)(22) Заявка: 2021110499, 15.04.2021 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): Общество с ограниченной ответственностью "МЭЙДЖИК ВЬЮ" (RU) ...

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03-02-2022 дата публикации

Устройство для визуализации вен в инфракрасном диапазоне

Номер: RU0000209146U1

Настоящая полезная модель относится к медицинской технике и медицинскому оборудованию, а именно к неинвазивному портативному устройству для визуализации подкожных вен с использованием источников света в инфракрасном (ИК) диапазоне и ИК-камеры. Предлагаемое устройство может быть использовано для неинвазивной визуализации периферийных подкожных вен при проведении таких венозных манипуляций, как: введение внутривенных инъекций, забор крови из вены, установка внутривенных катетеров, проведение склеротерапии, проведение диагностики и исследования сосудов и сосудистых нарушений. За счет использования длин волн ближнего ИК-диапазона происходит контрастная визуализация вен, так как свет с длиной волны более 700 нм проникает глубже в кожу. При этом ближний ИК-свет минимально поглощается меланином (высокомолекулярный пигмент кожи), но сильно поглощается кровью в венах. Это позволяет дифференцировать кровеносные сосуды и окружающие ткани. В частности, ближний ИК-свет, попадающий на участок тела человека, поглощается кровеносными сосудами. Чем больше ближний ИК-свет поглощается, тем меньше происходит его отражение, которое фиксирует ИК-камера. Чем меньше поглощают ближний ИК-свет окружающие ткани, тем больше они его отражают. Поэтому, изображение вен, полученное ИК-камерой, имеет темную контрастную структуру, а окружающие ткани имеют более светлый оттенок. Сущность полезной модели заключается в том, что устройство для визуализации вен в инфракрасном диапазоне, состоящее из принимающего устройства, корпуса, инфракрасной камеры с инфракрасными светодиодами и датчиком освещенности, соединенных между собой первой печатной платой, микроконтроллера, контроллера аккумуляторной батареи и драйвера инфракрасных светодиодов, соединенных между собой второй печатной платой, кнопки включения и аккумуляторной батареей, соединенных со второй печатной платой проводным соединением, передает изображение вен по беспроводному соединению Wi-Fi принимающему устройству (планшету, монитору, ...

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26-01-2012 дата публикации

Using muscle tension sensing to locate an analyte measurement site on the skin

Номер: US20120022347A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

Apparatus for determining where to locate a measuring device ( 3 ) on skin, the apparatus having a muscle tension sensing device ( 1 ) arranged to sense muscle tension at different locations on the skin, and a processor ( 2 ) for determining and outputting an indication of where to locate the measuring device on the muscle, based on the sensed muscle tensions. This can help make the skin measurements such as non invasive glucose measurements more consistent, and more accurate.

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09-02-2012 дата публикации

Brain information output apparatus, robot, and brain information output method

Номер: US20120035765A1

A brain information output apparatus includes an intention determination information storage unit in which two or more pieces of intention determination information can be stored, with each intention determination information including a pair of an intention identifier, and a learning feature amount group including one or more feature amounts extracted from second learning data that is obtained by converting first learning data into intracerebral brain activity data, the first leaning data being acquired from the outside of the cranium of a user when the user performs a trial according to one intention; a first brain activity data acquiring unit that acquires first brain activity data from the outside of the cranium of a user; a second brain activity data acquiring unit that converts the first brain activity data to intracerebral brain activity data, and acquires second brain activity data; a feature amount group acquiring unit that acquires, from the second brain activity data, an input feature amount group including one or more feature amounts; an intention identifier acquiring unit that acquires an intention identifier corresponding to the input feature amount group based on the two or more pieces of intention determination information; and an intention identifier output unit that outputs the intention identifier.

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01-03-2012 дата публикации

Trans-perineal prostate MR elastography

Номер: US20120053450A1
Принадлежит: Individual

The present invention relates to a method and apparatus for imaging the mechanical properties of the prostate of a patient non-invasively. The apparatus generally comprises a magnetic resonance scanner, a vibration assembly coupled to the perineal region of the patient, and a driver that drives the mechanical exciter. The method generally comprises positioning the vibration assembly against the perineal region of the patient, vibrating the mechanical exciter to cause deformational excitation of a tissue region contacted in the perineum, capturing a series of images in time (snapshots) of the tissue region using the MR scanner, and finally processing the displacement images to generate maps of mechanical properties of images tissue.

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15-03-2012 дата публикации

Measuring Instrument for Determining the Tissue Alcohol Concentration

Номер: US20120062879A1
Принадлежит: ROBERT BOSCH GMBH

A measuring instrument for determining the concentration of components in the body tissue by reflection spectroscopy is disclosed. In order, inter alia, to increase the functional reliability in the case of vibrations, the measuring instrument includes a diode laser with at least one laser diode and a waveguide structure, which has an external resonator, with a wavelength selective element, for each laser diode. In the process, the radiation generated by a laser diode is coupleable into the waveguide structure and the corresponding resonator and once again decoupleable from the resonator and the waveguide structure. Moreover, a corresponding method and a motor vehicle equipped therewith are disclosed.

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15-03-2012 дата публикации

Optical measurement apparatus

Номер: US20120065520A1
Принадлежит: Fujitsu Ltd

An optical measurement apparatus has a light source section, a light receiving section, and a light guiding section. The light source section has a light emitting surface that emits light. The light receiving section has a light receiving surface that receives the light emitted by the emitting surface of the light source to be incident into a body through a surface of the body and which is emitted out of the body after propagating inside the body, the receiving surface facing a direction orthogonal to the emitting surface of the light source, and the receiving section outputting a signal indicative of an amount of the light received by the receiving surface. The light guiding section is provided on a path of the light emitted from the emitting surface and received by the receiving surface to change a traveling direction of the light.

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22-03-2012 дата публикации

Methods of producing laser speckle contrast images

Номер: US20120071769A1
Принадлежит: University of Texas System

Methods of imaging are provided. In some embodiments, the methods may comprise obtaining a raw speckle image of a sample, converting the raw speckle image to a laser speckle contrast image using a laser speckle contrast algorithm, and converting a laser speckle contrast image to a relative correlation time image using a relative correlation time algorithm.

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29-03-2012 дата публикации

Methods for mapping tissue with optical coherence tomography data

Номер: US20120075584A1
Автор: Paul F. Stetson
Принадлежит: Carl Zeiss Meditec Inc

Various methods are disclosed for mapping optical coherence tomography (OCT) data to facilitate review and diagnosis. In one aspect, high resolution 2D line scans are obtained along with lower density 3D cube scans and displayed in a manner to provide context to the clinician. In another aspect, OCT data is analyzed to provide information about non-uniformities of the tissue. Binary image maps of maps useful for determining tautness of membranes are also disclosed.

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19-04-2012 дата публикации

Coupled Axial and Lateral Displacement Estimation for Elasticity Imaging

Номер: US20120095333A1
Принадлежит: Individual

The determination of axial and lateral displacement in a material subject to compression is determined by fitting a multi-dimensional model function to the match between corresponding portions of the material in two states of compression. In one embodiment, iso-contour lines in a correlation between a reference kernel and a target kernel are fit to an ellipse whose center defines the maximum correlation and hence the displacement.

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03-05-2012 дата публикации

Apparatus and method for multi-modal imaging using multiple x-ray sources

Номер: US20120106702A1
Автор: Gilbert D. Feke
Принадлежит: Carestream Health Inc

An imaging system for imaging at least a first and a second subject has a support stage to support the subjects. An imaging system has an ionizing radiation imaging section with at least a first ionizing radiation source for directing ionizing radiation within a first zone that includes the first subject and a second ionizing radiation source for directing ionizing radiation within a second zone that lies substantially outside the first zone and that includes the second subject. At least one imaging receiver forms an image of the subject within each zone. A camera system obtains at least one image of the at least first and second subjects. A computer is in signal communication with the imaging system and energizable to form a combined image from two or more images of the same subjects.

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03-05-2012 дата публикации

Body-worn sensor featuring a low-power processor and multi-sensor array for measuring blood pressure

Номер: US20120108983A1
Принадлежит: Sotera Wireless Inc

A system is described that continuously measures a patient's blood pressure over a length of time. The system features a sensor assembly featuring a flexible cable configured to wrap around a portion of a patient's arm. The flexible cable features a back surface that includes at least two electrodes that are positioned to contact the patient's skin to generate electrical signals. It additionally features an optical sensor that includes at least one light source and at least one photodetector. These components form an optical sensor that is configured to generate an optical signal by detecting optical radiation emitted by the at least one light source and reflected from a blood vessel underneath the patient's skin.

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14-06-2012 дата публикации

System and method for noninvasively monitoring conditions of a subject

Номер: US20120150014A1
Принадлежит: Or Nim Medical Ltd

A method and system are presented for use in determining one or more parameters of a subject. A region of interest of the subject is irradiated with acoustic tagging radiation, which comprises at least one acoustic tagging beam. At least a portion of the region of interest is irradiated with at least one electromagnetic beam of a predetermined frequency range. Electromagnetic radiation response of the at least portion of the region of interest is detected and measured data indicative thereof is generated. The detected response comprises electromagnetic radiation tagged by the acoustic radiation. This enables processing of the measured data indicative of the detected electromagnetic radiation response to determine at least one parameter of the subject in a region corresponding to the locations in the medium at which the electromagnetic radiation has been tagged by the acoustic radiation, and outputting data indicative of the at least one determined parameter.

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14-06-2012 дата публикации

Vacuum-pump sucker

Номер: US20120150042A1
Автор: Chi-Kuang Sun, Szu-Yu Chen
Принадлежит: National Taiwan University NTU

This invention relates to a vacuum-pump sucker for high-resolution microscopy comprising a sucker body and a transparent plate. The vacuum-pump sucker is designed as a stabilizer for sample stabilization in a clinical optical virtual biopsy system with sub-micron resolution. The sucker is connected with a vacuum pump. As the vacuum pump pumps out air or gas, tissues around the imaged area will be sucked by the sucker and the distance between objective lens and the imaged tissue can be stabilized. In this way, the stability and resolution of the clinical biopsy system can be greatly improved.

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21-06-2012 дата публикации

Calibration and measurement system

Номер: US20120157883A1
Автор: Thomas J. Richards
Принадлежит: Individual

Embodiments of the present invention include a calibration and measurement system designed primarily for use in the rapid evaluation and characterization of open or visible wounds in patients. The invention in a preferred embodiment comprises a set of colored concentric rings, typically constructed of paper or synthetic paper. The practitioner removes only as many rings, from the center outward, until the entire wound is visible within the open aperture at the center of the remaining rings. The area dimensions of the wound are then read out from the size of the inner remaining ring. Photography optionally records the wound appearance and size. A related system is developed for linear dimensioning of wounds. This embodiment is also designed to standardize the color scheme for accurate photography wound description. The color scheme is also applicable to a linear device to accurately describe wound size. Embodiments of the invention are also useful in forensic and accident investigations.

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05-07-2012 дата публикации

Acoustic wave measuring apparatus, acoustic wave imaging apparatus and method for controlling acoustic wave measuring apparatus

Номер: US20120167693A1
Автор: Yasufumi Asao
Принадлежит: Canon Inc

An acoustic wave measuring apparatus includes a light source for radiating a light having a wavelength component in wavelength areas, light filters arranged in a light path from the light source to a subject and each to shut off or transmit the light in one of the wavelength areas, a detector for detecting an acoustic wave generated by the radiation, a controller for generating conditions having different combinations of the wavelength components contained in the light, and a signal processor for calculating an optical absorption coefficient of the subject for the light in each wavelength area based on a pressure of the acoustic wave detected under each of the conditions and a strength of the radiated light for each wavelength area under conditions.

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26-07-2012 дата публикации

System for correlating energy field characteristics with target particle characteristics in the application of the energy field to a living organism for detection of invasive agents

Номер: US20120190978A1
Принадлежит: Actium Biosystems LLC

The Energy Field and Target Correlation System automatically correlates the characteristics of target particles and a living organism to compute the characteristics of an energy field that is applied to a living organism to activate the target particles which are bound to or consumed or taken up by invasive agents in the living organism to produce detectable effects which can be used to diagnose the presence and locus of the invasive agents. The energy field must be crafted to properly control the response and localize the extent of the illumination. The System automatically selects a set of energy field characteristics, including: field type, frequency, field strength, duration, field modulation, repetition frequency, beam size, and focal point. The determined energy field characteristics then are used to activate field generators to generate the desired energy field. A multi-dimensional image is produced identifying the spatial extent of the invasive agent.

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02-08-2012 дата публикации

Apparatus and methods for monitoring physiological data during environmental interference

Номер: US20120197093A1
Принадлежит: Individual

Apparatus and methods for attenuating environmental interference are described. A wearable monitoring apparatus includes a housing configured to be attached to the body of a subject and a sensor module that includes an energy emitter that directs energy at a target region of the subject, a detector that detects an energy response signal—or physiological condition—from the subject, a filter that removes time-varying environmental interference from the energy response signal, and at least one processor that controls operations of the energy emitter, detector, and filter.

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16-08-2012 дата публикации

Soft tissue elasticity distribution measurement method and soft tissue elasticity distribution measurement device

Номер: US20120209146A1
Принадлежит: Nagoya Institute of Technology NUC

An aspiration chamber is provided with an aspiration aperture, having a shape in which a width becomes larger from one edge toward another edge, and aspirates soft tissue through the aspiration aperture. A deformation amount measurement portion measures aspiration deformation amounts of the soft tissue within the aspiration aperture along a virtual line from the one edge to another edge. Based on the aspiration deformation amounts that have been measured by the deformation amount measurement portion, a computer uses a finite element model of the soft tissue to derive an approximation equation according to a numerical function for the aspiration deformation amounts and positions on the virtual line and determines a distribution of elasticity from the surface of the soft tissue into its interior by substituting parameters of the approximation equation into estimation equations that are derived by assuming that the deformation along the virtual line reflects elasticity distribution parameters.

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23-08-2012 дата публикации

Noninvasive cutaneous blood flow assessment as a response predictor for visible light therapy on segmental vitiligo

Номер: US20120215120A1
Принадлежит: KAOHSIUNG MEDICAL UNIVERSITY

Visible light is a treatment option for Segmental Vitiligo (SV), and visible light-induced repigmentation is associated normalization of sympathetic. Currently it is difficult to predict individual patient's response to visible light therapy. Therefore, the present invention uses the Laser Doppler Flowmeter to serve as a response predictor for visible light on treating SV. The present invention recruited 14 Segmental Vitiligo patients for evaluating clinical information. FirstLaser Doppler Flowmeter was used to evaluate the cutaneous blood flow of SV lesion and contralateral normal skin, and then treated them with visible light irradiate, cold-stress, rewarmed, and recorded the change of skin blood flow, finally the patients received regular visible light treatment for 3 months, and patients have a sign of repigmentation after the treatment.

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20-09-2012 дата публикации

Optical measurement system, portable optical measurement device used therein, and rehabilitation planning method using same

Номер: US20120238883A1
Принадлежит: Shimadzu Corp

An optical measurement system having a main and a portable optical measurement devices. The portable optical measurement device is provided with a second case portable by the subject, C second light sending means for illuminating the subject, D second light receiving means receiving light emitted from the subject, a second holder worn on the head of the subject and having at least (C+D) through holes therein, a control unit acquiring measurement data relating to a brain activity while controlling the second light sending and receiving means, and a communication unit communicating with the main optical measurement device, that (C+D)>(A+B) is satisfied, and that the communication unit of the portable optical measurement device transmits the measurement data acquired by the control unit of the portable optical measurement device to the main optical measurement device.

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27-09-2012 дата публикации

Subject information acquisition apparatus and subject information acquisition method

Номер: US20120243369A1
Принадлежит: Canon Inc

A subject information acquisition apparatus includes: an acoustic wave detector which detects an acoustic wave which is generated from a subject by irradiating light and outputs a detection signal; an amplifier which amplifies the detection signal which is output from the acoustic wave detector; a gain control unit which changes a gain of the amplifier as time elapses, according to a gain control table, in order to correct a drop in intensity of the acoustic wave caused by attenuation of fluence inside the subject; and a signal processing unit which obtains information inside the subject based on the signal amplified by the amplifier. Measurement under a plurality of measurement conditions, where at least fluence distribution inside the subject or a position of the acoustic wave detector differs, is possible, and the gain control unit changes the gain control table according to the measurement conditions.

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13-12-2012 дата публикации

Process, arrangements and systems for providing frequency domain imaging of a sample

Номер: US20120316434A1
Принадлежит: General Hospital Corp

Exemplary apparatus, arrangement and method can be provided for obtaining information associated with an anatomical structure or sample using optical microscopy. A radiation can include first electromagnetic radiation(s) directed to an anatomical sample and at least one second electromagnetic radiation directed to a reference. A wavelength of the radiation can vary over time, and the wavelength can be shorter than approximately 1150 nm. An interference can be detected between third and forth radiations associated with the first, second and fourth radiation, respectively. At least one image corresponding to portion(s) of the sample can be generated using data associated with the interference. Source arrangement(s) can be provided which is configured to provide an electromagnetic radiation having a wavelength that varies over time. A period of a variation of the wavelength of the first electromagnetic radiation(s) can be shorter than 1 millisecond, and the wavelength can be shorter than approximately 1150 nm.

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03-01-2013 дата публикации

Homogenizing Light Sources in Photoplethysmography

Номер: US20130006074A1
Автор: Jonas A. Pologe
Принадлежит: Kestrel Labs Inc

An embodiment of a light homogenizing apparatus having one or more emitters ( 110, 120 ) incident on a light mixing element. The emitters including at least one laser light source. The light mixing element comprising a diffuser ( 130 ) followed by an internally reflective light guide ( 160 ). This apparatus substantially homogenizes light from all emitters ( 110, 120 ) before light exits the internally reflective light guide ( 160 ) where it could then be incident on living tissue for use in photoplethysmographic measurement. Other embodiments are described and shown.

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03-01-2013 дата публикации

System and method for sub-surface fluorescence imaging

Номер: US20130006116A1
Принадлежит: UNIVERSITY HEALTH NETWORK

Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.

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03-01-2013 дата публикации

Fibers in therapy and cosmetics

Номер: US20130006119A1
Принадлежит: Merck Patent GmBH

The present invention relates inter alia to functional materials for the treatment and/or prophylaxis and/or diagnosis of diseases and/or cosmetic conditions. The functional materials can be used for the preparation of light emitting devices comprising fibers as light emitting elements.

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03-01-2013 дата публикации

Probe structure, temperature measuring device having the probe structure, and method using the same

Номер: US20130006138A1
Автор: Chia-Chen Ho
Принадлежит: MICROLIFE INTELLECTUAL PROPERTY GMBH

The present invention relates to a probe structure, a temperature measuring device having the probe structure, and a method of using the same. The probe structure comprises a light transmissive unit and one or more light sources. One or more light sources radiate one or more colors of light to and through the light transmissive unit. The temperature measuring device includes the above-mentioned probe structure and a temperature measuring body. The probe structure is assembled within the temperature measuring body. By the design of the light transmissive unit and the visual light provided by the light sources, the user can easily place the probe structure to the part to be measured.

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17-01-2013 дата публикации

Capillary refill time diagnostic apparatus and methods

Номер: US20130018241A1
Принадлежит: Childrens Medical Center Corp

An apparatus for measuring capillary refill time has a measurement module containing at least two radiation sources and at least one detector configured to detect radiation from each source that interacts with and is received from a measurement region of a patient or subject. One radiation source may be characterized by a wavelength that is absorbed substantially equally by oxyhemoglobin and deoxyhemoglobin. The other radiation source may be substantially unaffected by the presence or absence of blood in the measurement region. The measurement module may be applied against a measurement region of a patient for a first time period, and the released from the measurement region for a second time period, and detected signals processed to quantitatively evaluate capillary refill time.

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21-03-2013 дата публикации

METHOD FOR DETERMINING STAGE OF CHRONIC KIDNEY DISEASE, DEVICE THEREFOR AND METHOD FOR OPERATING THE SAME

Номер: US20130068945A1
Принадлежит:

This invention provides a method or device for determining the stage of chronic kidney disease. 1. A method for determining a stage of chronic kidney disease in a subject suffering from kidney disease , the method comprising the steps of:(A-1) measuring the content of at least one marker selected from the group consisting of markers (1) to (16) shown below by subjecting a specimen from the subject using liquid chromatography/time of flight mass spectrometry under the following conditions:Liquid-Chromatography ConditionsLiquid-chromatography equipment: Agilent 1100 Series (Agilent);Column: Cadenza C18 2×150 mm, 3 μm (Imtakt);Pre-column: TCI OPTI-GUARD Fit ODS (TCI);Mobile phase A: 0.05% formic acid;Mobile phase B: acetonitrile;For gradient elution:0 to 15 min: linear gradient from 5% to 95% mobile phase B in mobile phase A,15 to 20 min: linear gradient from 95% to 100% mobile phase B in mobile phase A, and20 to 35 min: 100% mobile phase B is kept;Flow rate: 0.2 mL/min; andMeasurement sample content: 5 μL.Time of Flight Mass Spectrometry ConditionsMeasuring range: m/z 70 to 1,000;Orifice 1 voltage: 10 to 40V, −10 to (−40) V sweep;Ion guide voltage: 500 to 2,500 V sweep;Detector: 2,800 V; andMeasuring equipment: Accu TOF JMS-T100LC (JEOL).Markers{'sup': '+', '(1): marker having a retention time of 2.03±0.5 (min) and an accurate mass (m/z) of 104.10±10 mDa in positive ion measurement [M+H];'}{'sup': '+', '(2): marker having a retention time of 3.80±0.5 (min) and an accurate mass (m/z) of 257.10±10 mDa in positive ion measurement [M+H];'}{'sup': '+', '(3): marker having a retention time of 6.52±0.5 (min) and an accurate mass (m/z) of 312.12±10 mDa in positive ion measurement [M+H];'}{'sup': '+', '(4): marker having a retention time of 6.87±0.5 (min) and an accurate mass (m/z) of 232.15±10 mDa in positive ion measurement [M+H];'}{'sup': '+', '(5): marker having a retention time of 8.32±0.5 (min) and an accurate mass (m/z) of 265.12±10 mDa in positive ion measurement [M+H ...

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04-04-2013 дата публикации

System and method for calibration of optical fiber instrument

Номер: US20130085332A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

An instrument system that includes an elongate body in a geometric configuration, an optical fiber, and a controller is provided. The optical fiber is operatively coupled to the elongate body and has a strain sensor provided on the optical fiber, wherein at least a portion of the optical fiber is in the geometric configuration. The controller is operatively coupled to the optical fiber and adapted to receive, from a source other than the optical fiber, information indicative of the geometric configuration, receive a signal from the strain sensor, and associate the signal with the geometric configuration.

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04-04-2013 дата публикации

Degree of hardness measurement system and degree of hardness measurement method

Номер: US20130085417A1
Принадлежит: HITACHI LTD

For measuring hardness of an object, a measurement apparatus is pushed against the object and a degree of hardness calculation system calculates hardness based on information from the measurement apparatus. The measurement apparatus includes an acceleration sensor which outputs first information of acceleration of a contact area of the measurement apparatus, and a second sensor, such as a magnetic sensor or a pressure sensor, which outputs second information based on pressure applied to the contact area. The degree of hardness calculation system generates a second-derivative waveform by twice differentiating a waveform based on the output of the second sensor, compares the second-derivative waveform and the information of acceleration from the acceleration sensor, and calculates hardness of the object based on the comparison result.

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11-04-2013 дата публикации

SYSTEM AND METHOD FOR SENSING SHAPE OF ELONGATED INSTRUMENT

Номер: US20130090552A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

An instrument system that includes a first optical fiber, a second optical fiber and a controller is provided. The first optical fiber is operatively coupled to an elongate body that is adapted to be placed inside a patient. The second optical fiber is operatively coupled to the patient, to an actuating element adapted to actuate the elongate body, or to a portion of an imaging system adapted to identify a location of the portion relative to the elongate body. The controller is operatively coupled to the first optical fiber and the second optical fiber and is adapted to receive a first signal from the strain sensor provided on the first optical fiber, receive a second signal from the strain sensor provided on the second optical fiber; and determine a position or orientation of the elongate body based on the first signal and based on the second signal. 1. An instrument system , comprising:a first optical fiber operatively coupled to an elongate body that is adapted to be placed inside a patient, the first optical fiber having a strain sensor provided thereon;a second optical fiber having a strain sensor provided thereon, the second optical fiber operatively coupled to the patient, to an actuating element adapted to actuate the elongate body, or to a portion of an imaging system adapted to identify a location of the portion relative to the elongate body; and receive a first signal from the strain sensor provided on the first optical fiber;', 'receive a second signal from the strain sensor provided on the second optical fiber; and, 'a controller operatively coupled to the first optical fiber and the second optical fiber and adapted todetermine a position or orientation of the elongate body based on the first signal and based on the second signal.2. The instrument system of claim 1 , wherein the second optical fiber is operatively coupled to a surface of the patient. claim 1 , the instrument system further comprising:a third optical fiber operatively coupled to the ...

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25-04-2013 дата публикации

Micro Vein Enhancer

Номер: US20130102905A1

The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

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02-05-2013 дата публикации

BABY MONITORING MAT BASED ON FIBER OPTIC SENSOR

Номер: US20130109931A1
Принадлежит: Excelpoint Technology Limited

The present invention provides a baby monitoring mat having a sensor mat having a top mesh layer, a bottom mesh layer, and two flexible sheets and an optical cable, wherein the optical cable is routed across and sandwiched in between the top mesh layer and the bottom mesh layer, and the flexible sheets further sandwiched the top mesh layer and the bottom mesh layer in between forming sensing area across the flexible sheet surface; a light source for feeding light from one side of the optical cable; a photodiode for detecting light attenuation at the other end of the optical cable; a printed circuit board having a processor connected to the light source and the photodiode, wherein the processor operationally receives signals from the photodiode, the signals are processed to determine movements and breath counts. The signals are generated based on the light attenuation changes along the optical fiber cable detected by photodiode, the light attenuation changes are operationally caused by the optical fiber bending lost caused by the movements and breath. A method for monitoring baby on a mat is also provided. 1. A Baby Monitoring Mat , comprising:a sensor mat having a top mesh layer, a bottom mesh layer, and two flexible sheets and an optical cable, wherein the optical cable is routed across and sandwiched in between the top mesh layer and the bottom mesh layer, and the flexible sheets further sandwiched the top mesh layer and the bottom mesh layer in between forming sensing area across the flexible sheet surface;a light source for feeding light from one side of the optical cable;a photodiode for detecting light attenuation at the other end of the optical cable;a printed circuit board having a processor connected to the light source and the photodiode, wherein the processor operationally receives signals from the photodiode, the signals are processed to determine movements and breath counts,wherein the signals are generated based on the light attenuation changes along ...

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09-05-2013 дата публикации

DUAL PRESSURE SENSOR SIGNAL CHAIN TO REMOVE MUTUALLY-COUPLED MRI INTERFERENCE

Номер: US20130116544A1
Автор: Cates Harold, Rey Eduardo
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

Apparatus and methods provide a physiological status sensing device () for sensing a physiological status of a patient () and minimizing an amount of interference () generated during a resonance (MR) scan by a magnetic resonance (MR) system (). The device () includes a first, active sensor () located to sense the physiological status and experience MR scan related interference and to generate a first signal () having a physiological status component () and an interference component (). A second non-active sensor () is located closely adjacent to the first sensor () to experience substantially the same MR scan related interference () as the first sensor () and generate a second signal () having only the interference component (). A circuit or processor () subtractively combines the first () and second signals () to cancel the interference component (). 1. A physiological status sensing device for sensing a physiological status of a patient and minimizing an amount of interference generated during a magnetic resonance (MR) scan by a magnetic resonance (MR) system , the device comprising:a first, active sensor located to sense the physiological status and experience MR scan related interference and to output a first signal having a physiological status component and an interference component;a second, non-active sensor located closely adjacent to the first sensor to experience substantially the same MR scan related interference as the first sensor and output a second signal having the interference component; anda circuit which subtractively operates on the first and second signals to cancel the interference component.2. The device according to claim 1 , wherein the first sensor includes a first piezoresistive pressure transducer which senses a pressure related to the physiological status and the second sensor includes a second piezoresistive pressure transducer of like construction with the first piezoelectric pressure transducer claim 1 , the second pressure ...

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16-05-2013 дата публикации

Medical Workflow System and Method

Номер: US20130123616A1
Принадлежит: VOLCANO CORPORATION

A method of conducting a medical workflow with a touch-sensitive bedside controller is disclosed. The method includes initiating a medical workflow using a graphical user interface on the bedside controller, positioning an imaging tool within a patient's body based on images captured by the imaging tools and displayed on the bedside controller, controlling the commencement and termination of a recordation of images captured by the imaging tool using the graphical user interface on the bedside controller, navigating through the recorded images to identify an image of interest using the graphical user interface on the bedside controller, and performing measurements on the image of interest using the graphical user interface on the bedside controller. 1. A method of conducting a medical workflow with a touch-sensitive bedside controller , the method comprising:initiating a medical workflow using a graphical user interface on the bedside controller;positioning an imaging tool within a patient's body based on images captured by the imaging tools and displayed on the bedside controller;controlling the initiation and termination of a recordation of images by the imaging tool using the graphical user interface on the bedside controller;navigating through the recorded images to identify an image of interest using the graphical user interface on the bedside controller; andperforming measurements on the image of interest using the graphical user interface on the bedside controller.2. The method of claim 1 , wherein the initiating includes selecting the medical workflow out of a plurality of medical workflows presented as selectable options within the graphical user interface.3. The method of claim 2 , wherein the plurality of medical workflows includes two or more of an intravascular ultrasound (IVUS) imaging workflow claim 2 , an intravascular photoacoustic (IVPA) imaging workflow claim 2 , an optical coherence tomography (OCT) workflow claim 2 , a forward looking IVUS (FL- ...

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16-05-2013 дата публикации

MEASURING METHOD OF LIFE ACTIVITY, MEASURING DEVICE OF LIFE ACTIVITY, TRANSMISSION METHOD OF LIFE ACTIVITY DETECTION SIGNAL, OR SERVICE BASED ON LIFE ACTIVITY INFORMATION

Номер: US20130123639A1
Автор: Ando Hideo
Принадлежит:

According to a measuring method or a control method of life activity, a life object is illuminated with an electromagnetic wave including a wavelength in a designated waveband, and a characteristic in a local area of the life object is detected, or a life activity thereof is controlled. This “local area” is an area constituted by one or more cells. The “designated waveband” is defined based on any one of the following phenomena: 1. A detecting method of life activity , comprising:illuminating the life object with an electromagnetic wave of which a wavelength is included in a designated waveband or the wavelength relates to a designated peak; anddetecting the activity at least in a local area in the life object.2. A controlling method of life activity , comprising:illuminating the life object with an electromagnetic wave of which a wavelength is included in a designated waveband or the wavelength relates to a designated peak; andcontrolling the activity at least in a local area in the life object.3. A transmission method of information related to life activity , comprising:illuminating the life object with an electromagnetic wave of which a wavelength is included in a designated waveband or the wavelength relates to a designated peak; andtransmitting information obtained on the basis of detection of the activity at least in a local area in the life object.4. The detecting method of life activity according to claim 1 , wherein:the designated waveband relates to a wavelength of not less than 0.84 μm but not more than 110 μm.5. The detecting method of life activity according to claim 1 , whereinthe designated peak relates to a chemical shift value in a range of not less than δ1.7 ppm but not more than δ4.5 ppm.6. The designated method of life activity according to claim 1 , whereinthe designated waveband is determined on the basis of transition energy between a plurality of states constituted by a specific ground state in the local area which ground state is able to ...

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23-05-2013 дата публикации

Recanalizing occluded vessels using radiofrequency energy

Номер: US20130131513A1
Автор: Osamu Katoh, Wayne Ogata
Принадлежит: RetroVascular Inc

A method and systems for treating chronic total occlusions, particularly those that are difficult to treat, is disclosed. In this approach, recanalizing the CTO is achieved using a combined antegrade and retrograde approach. The proximal end of the occlusion is penetrated using an antegrade wire, using a traditional approach. Using collateral vessels, the distal end of the occlusion is crossed in a retrograde fashion. By appropriately maneuvering each member and applying radiofrequency energy between the proximal and distal ends of the occlusion, a continuous channel is created.

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13-06-2013 дата публикации

MULTI-LUMEN THORACIC CATHETER AND USES THEREOF

Номер: US20130150701A1
Принадлежит:

A multi-lumen catheter for use in a cavity having a main lumen surrounded by a wall, and at least one access lumen positioned in or on the wall, the one access lumen conveys a solution to the cavity and said main lumen. A method for treating or preventing fluid or accumulation in a body cavity including (a) aseptically inserting through an incision at an insertion site the catheter comprising a main drainage lumen surrounded by a wall and the one access lumen positioned in or on the wall, (b) securing the inserted catheter by closing the incision with a suture, (c) infusing a physiological solution through the one access lumen to dilute a drainage fluid, (d) connecting a distal end of a main drainage lumen of the catheter to a suction drainage system, and (e) applying a vacuum force to the suction drainage system to remove the diluted drainage fluid. 1. A multi-lumen catheter for use in a cavity , comprising a main lumen surrounded by a wall; and at least one access lumen positioned in or on the wall , wherein said at least one access lumen conveys a solution to the cavity and said main lumen.2. A method for treating or preventing fluid accumulation or air accumulation in a body cavity of a subject using the multi-lumen catheter of claim 1 , the method comprising:(a) aseptically inserting through an incision at an insertion site of the subject the multi-lumen catheter comprising a main drainage lumen surrounded by a wall and at least one access lumen positioned in or on the wall;(b) securing the inserted multi-lumen catheter by closing the incision with a suture;(c) infusing a physiological solution through at least one access lumen of the multi-lumen catheter to dilute a drainage fluid;(d) connecting a distal end of a main drainage lumen of the multi-lumen catheter to a suction drainage system; and(e) applying a vacuum force to the suction drainage system to remove the diluted drainage fluid.3. The method according to claim 2 , wherein the body cavity is a pleural ...

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20-06-2013 дата публикации

Device Embodied to Measure Vital Parameters of a Patient

Номер: US20130158364A1
Принадлежит: ROBERT BOSCH GMBH

A measuring device includes a plurality of measuring modules and a control module. The plurality of measuring modules is configured to measure vital parameters of a patient, with at least two measuring modules of the plurality of measuring modules being configured to measure different vital parameters. The control module is configured to evaluate the measured vital parameters and/or to carry out calculations based on the measured vital parameters. 1. A measuring device , comprising:a plurality of measuring modules configured to measure vital parameters of a patient, with at least two measuring modules of the plurality of measuring modules being configured to measure different vital parameters; anda control module configured to evaluate the measured vital parameters and/or to carry out calculations on the basis of the measured vital parameters.2. The measuring device according to claim 1 , wherein:the measuring device has a modular configuration,the plurality of measuring modules are removable from the measuring device,the plurality of measuring modules are replaceable, and/orat least one new measuring module is addable to the measuring device.3. The measuring device according to claim 1 , further comprising:a plurality of interfaces configured to connect the measuring modules to the control module.4. The measuring device according to claim 1 , wherein the control module is further configured (i) to calculate characteristics based on the measured vital parameters claim 1 , and/or (ii) to calculate further information in respect of the patient based on the measured vital parameters.5. The measuring device according to claim 4 , wherein:the control module is further configured to compare the calculated characteristics to predetermined limits, andthe measuring device is configured to display a result of the comparison.6. The measuring device according to claim 4 , wherein the measuring device is further configured to identify the patient based on patient-specific ...

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20-06-2013 дата публикации

Device and method for measuring pressure exerted on a surface

Номер: US20130158436A1
Принадлежит: University of Illinois

Provided are methods and devices for measuring pressure exerted against a surface. In an aspect, the surface corresponds to the urethra and the device measures the pressure exerted against the urethra. Methods include treatment of a patient suffering urinary stress incontinence. A pressure sensor system is used to determine, pre-surgically, the minimum pressure required to alleviate incontinence. During surgery, the pressure sensor system is employed to ensure the surgical intervention provides a corresponding minimum pressure that was clinically identified. In this manner, the surgical intervention is precisely monitored and measured to insure the appropriate pressure is exerted on the urethra to alleviate stress incontinence, thereby improving surgical outcome and decreasing post-operative complications.

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27-06-2013 дата публикации

Mobility identity platform

Номер: US20130162799A1
Принадлежит: EyeLock Inc

The present disclosure is directed towards a compact, mobile apparatus for iris image acquisition, adapted to address effects of ocular dominance in the subject and to guide positioning of the subject's iris for the image acquisition. The apparatus may include a sensor for acquiring an iris image from a subject. A compact mirror may be oriented relative to a dominant eye of the subject, and sized to present an image of a single iris to the subject when the apparatus is positioned at a suitable distance for image acquisition. The mirror may assist the subject in positioning the iris for iris image acquisition. The mirror may be positioned between the sensor and the iris during iris image acquisition, and transmit a portion of light reflected off the iris to the sensor.

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04-07-2013 дата публикации

Health monitoring appliance

Номер: US20130172691A1
Автор: Bao Tran
Принадлежит: Individual

A heart monitoring system for a person includes one or more wireless nodes forming a wireless network; a wearable body sensor having a wireless transceiver adapted to communicate with the one or more wireless nodes.

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04-07-2013 дата публикации

Devices and methods for control of blood pressure

Номер: US20130172981A1
Принадлежит: Vascular Dynamics Inc

Apparatus and methods are described including an implantable device having first and second longitudinal ends, the device having a length of less than 80 mm when the device is unconstrained. The device includes struts arranged such that, when the device is unconstrained, along a continuous portion of the device having a length that is at least 5 mm, a maximum inter-strut distance defined by any set of two adjacent struts is more than 1.5 times as great as a maximum inter-strut distance defined by any set of two adjacent struts within longitudinal portions of the device within 3 mm of the longitudinal ends of the device. Other applications are also described.

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25-07-2013 дата публикации

METHOD FOR DETERMINING A DEVIATION OF A MEDICAL INSTRUMENT FROM A TARGET POSITION

Номер: US20130190611A1
Автор: GRAUMANN Rainer
Принадлежит: SIEMENS AKTIENGESELLSCHAFT

In a method for determining a deviation of a medical instrument from a target position, in an image of an implant located in the body of a patient created with an imaging system, a virtual model of the implant is fitted at the correct location and thus a location of the implant is determined in the imaging system. On a basis of the location of the virtual model in the imaging system and a target position for an instrument selected as a fixed position relative to the virtual model, the location of the target position in the imaging system is determined. A video image of the instrument is created by a recording device and its current location in relation to the recording device is determined from this. By a geometrical relationship between the recording device and the imaging system, a deviation of the instrument from the target position is determined. 1. A method for determining a deviation of a medical instrument from a target position , which comprises the steps of:a) fitting, in an image of an implant disposed in a body of a patient created with an imaging system, a virtual model of the implant at a correct location and thus a location of the implant is determined in the imaging system;b) determining a further location of the target position in the imaging system on a basis of the correct location of the virtual model in the imaging system and the target position for the medical instrument selected as a fixed position relative to the virtual model;c) creating a video image of the medical instrument by a recording device and determining a current location of the medical instrument in relation to the recording device from the video image; andd) determining a deviation of the medical instrument from the target position by means of a known geometrical relationship between the recording device and the imaging system.2. The method according to claim 1 , which further comprises claim 1 , on a basis of the deviation claim 1 , determining a correction parameter claim 1 , ...

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01-08-2013 дата публикации

Ultrasonic probe and inspection apparatus equipped with the ultrasonic probe

Номер: US20130197345A1
Принадлежит: Canon Inc

An ultrasonic probe includes a light irradiating portion configured to radiate light for generating ultrasonic waves from a light absorber, an ultrasonic transducing portion configured to transduce the ultrasonic waves to an electric signal, and a light guide member configured to introduce light from a light source to the light irradiating portion. A light irradiating region of the light irradiating portion is included within an ultrasonic receiving region of the ultrasonic transducing portion.

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08-08-2013 дата публикации

A PRESENCE DETECTION SYSTEM AND A LIGHTING SYSTEM

Номер: US20130200254A1
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

A presence detection system () for detecting a living being () within an area (). The area () comprises at least two zones (A;B). The system () in total comprises at least two light sources (A;B) each of them having a different predefined spectrum and each of them radiating light in a different zone (A;B). The system comprises at least two sensing means (A;B) sensitive to light of the first predefined spectrum and the second predefined spectrum respectively. Each of the sensing means (A;B) is arranged for detecting light reflected from the living being () if present in the zone (A;B) of the area () and for generating a presence signal (A;B) based on detected light. The system comprises a processor device () that concludes the presence of the living being () within the area () in a zone wise way based on the presence signals. Such presence detection system provides relatively precise presence detection. The invention also relates to a lighting system comprising the above mentioned presence detection system (). 1. A presence detection system for detecting a living being within an area comprising at least two zones , the system comprising:at least two light sources each of them having a different predefined spectrum, a first spectrum and a second spectrum, and each of them radiating light in a different zone, andat least two sensing means sensitive to light of the first predefined spectrum and the second predefined spectrum respectively, wherein each of the sensing means is arranged for detecting light reflected from the living being if present in the zone of the area and for generating a presence signal based on detected light,a processor device for concluding the presence of the living being within the area based on the presence signals.2. The presence detection system as claimed in claim 1 , wherein the sensing means comprises a photo sensor sensitive to the light of the predefined spectrum.3. The presence detection system as claimed in claim 1 , wherein the sensing ...

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08-08-2013 дата публикации

ENHANCED MULTI-CORE BEAMFORMER ALGORITHM FOR SENSOR ARRAY SIGNAL PROCESSING

Номер: US20130204114A1
Принадлежит:

Techniques and systems are disclosed for implementing multi-core beamforming algorithms. In one aspect, a method of implementing a beamformer technique includes using a spatial filter that contains lead-fields of two simultaneous dipole sources rather than a linear combination of the two to directly compute and obtain optimal source orientations and weights between two highly-correlated sources. 1. A method of implementing an enhanced beamformer technique , the method comprising:{'sub': 'ŝ', 'reconstructing a source power covariance matrix Rbetween multiple sources to determine individual time-courses and correlations for sources in low SNR conditions.'}2. The method of claim 1 , wherein the enhanced beamformer technique comprises an enhanced dual-core beamformer (eDCBF) technique.3. The method of claim 2 , wherein the eDCBF uses a single computation of a weight matrix for accurate correlation determination.4. The method of claim 3 , wherein the eDCBF weighting matrix is defined as the m×4 matrix W=[WW] claim 3 , where Ware the individual weighting matrices for each source claim 3 , ensuring no reduction in rank and enabling the computation of unique source time-courses and correlation.5. The method of claim 1 , wherein the beamformer technique comprises an enhanced multi-core beamformer (eMCBF) reconstruction.6. The method of claim 5 , wherein the eMCBF comprises:detecting an orientation (direction) of signals to allow correlation and reconstruction of multiple interfering sources at the same time.7. A method of implementing a beamformer technique claim 5 , the method comprising:using a spatial filter that contains lead-fields of two simultaneous dipole sources rather than a linear combination of the two to directly compute and obtain optimal source orientations and weights between two highly-correlated sources.8. The method of claim 7 , comprising:using a magnetoencephalography (MEG) inverse-modeling technique to reduce a computational time.9. The method of claim ...

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08-08-2013 дата публикации

SYSTEM AND METHOD FOR COLLECTION & USE OF MAGNETIC RESONANCE DATA & MICROWAVE DATA TO IDENTIFY BOUNDARIES OF INTEREST

Номер: US20130204118A1
Принадлежит: Dartmouth College

A system and method for detecting permittivity and conductivity boundaries within a high resolution spatial image of a material is presented. Electrical properties of a material, such as permittivity and conductivity, may assist in identification of physical properties of the material. Structural boundaries within tissue may be identified in spatial images, such as MR images. Image reconstruction algorithms may combine these structural boundaries with microwave images of the tissue to determine the permittivity and conductivity parameters within the structural boundaries. In the case of soft tissue, the microwave images may be captured simultaneously with the spatial images. The microwave images may be taken at a different time from the spatial image for rigid tissue. The method may be employed for two dimensional or three dimensional image reconstruction. 1. A method for use of spatial resolution data and microwave data to identify region boundaries of interest in soft tissue , wherein the method comprises the steps of:simultaneously gathering spatial resolution data and microwave data from the soft tissue;creating a customized mesh segmented into multiple subzones from spatial information resulting from the gathered spatial resolution data; andperforming image reconstruction using spatial information resulting from the gathered spatial resolution data and gathered microwave data.2. The method of claim 1 , further comprising the step of identifying boundaries between regions within the spatial resolution data.3. The method of claim 1 , further comprising the step of identifying regions having the same or similar dielectric properties.4. The method of claim 3 , further comprising the step of penalizing a variation within the regions identified to have the same or similar dielectric properties.5. The method of claim 4 , further comprising the step of restricting smoothing across a boundary shared by a first region within the gathered spatial resolution data ...

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08-08-2013 дата публикации

DEVICE FOR USE IN ELECTRO-BIOLOGICAL SIGNAL MEASUREMENT IN THE PRESENCE OF A MAGNETIC FIELD

Номер: US20130204122A1

A measurement device is presented for use in an EEG measurement performed in the presence of a magnetic field. The device comprises a wiring array for connecting an electrodes arrangement to an electroencephalogram (EEG) monitoring device. The wiring array comprises a plurality of sampling lines arranged to form a first group of sampling lines arranged in a spaced-apart substantially parallel relationship extending along a first axis, at least some of said sampling lines being wire bundles of said first group comprising a plurality of first wires for connecting to a corresponding first plurality of electrodes of said EEG electrodes arrangement; and a second group of sampling lines arranged in a spaced-apart substantially parallel relationship extending along a second axis, intersecting with said first axis, such that said second group of bundles crosses said first group of bundles to form a net structure, at least some of said sampling lines being wire bundles of said second group comprising a plurality of second wires for connecting to a corresponding second plurality of electrodes of said EEG electrodes' arrangement. The wiring array is configured and operable for transmitting a signal measured by the respective electrodes to the EEG monitoring device, enabling generation of EEG data indicative of the neural signal profile along tow directions and characterized by reduced motion artifact and/or reduced gradient artifact associated with the presence of the magnetic field during the EEG measurement. 1. A measurement device for use in an EEG measurement performed in the presence of a magnetic field , the device comprising a wiring array for connecting an electrodes arrangement to an electroencephalogram (EEG) monitoring device , wherein:the wiring array comprises a plurality of sampling lines arranged to form a first group of sampling lines arranged in a spaced-apart substantially parallel relationship extending along a first axis, at least some of said sampling ...

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08-08-2013 дата публикации

PHYSIOLOGICAL SENSOR

Номер: US20130204141A1
Принадлежит: Covidien IP

A sensor used to measure physiological characteristics of body tissues is provided. The physiological sensor includes a first light source assembly having a first light source in parallel with a second light source. Each of the first light source and the second light source have an anode and a cathode. A second light source assembly includes a third light source in parallel with a fourth light source. Each of the third light source and the fourth light source have an anode and a cathode. The anode of the first light source is electrically connected to the cathode of the second light source, the anode of said third light source, and the cathode of said fourth light source. The anode of the third light source is electrically connected to the cathode of the fourth light source. 113-. (canceled)14. A sensor comprising:a first light source assembly including a first light source and a second light source, each of said first light source and said second light source having an anode and a cathode;a second light source assembly including a third light source and a fourth light source, each of said third light source and said fourth light source having an anode and a cathode; andwherein said anode of said first light source is electrically connected to each of said cathode of said second light source, said anode of said third light source, and said cathode of said fourth light source and wherein said anode of said third light source is electrically connected to said cathode of said fourth light source.15. The sensor of claim 16 , wherein said cathode of said first light source is electrically connected to said anode of said second light source and said cathode of said second light source is electrically connected to said cathode of said fourth light source.16. The sensor of claim 14 , further comprising a third light source assembly including a fifth light source and a sixth light source and each of said fifth light source and said sixth light source having an anode and a ...

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22-08-2013 дата публикации

EQUINE WIRELESS PHYSIOLOGICAL MONITORING SYSTEM

Номер: US20130217980A1
Автор: ELSER Andrew H.
Принадлежит: DR. ANDREW H. ELSER, V.M.D., P.C.

An accelerometer senses equine respiratory structural vibrations. The accelerometer includes a sensing surface configured to be attached to one of hair, skin, bone, ligament, cartilage, and other tissue of a horse. The accelerometer is responsive to respiratory structural vibrations of the horse and outputs a signal corresponding to the respiratory structural vibrations. 1. An equine physiological monitoring system for monitoring interactions of physiological events of an exercising horse , the system comprising:(a) a first sensor configured to be mounted proximate to the horse so as to move with the horse, the first sensor outputting detected first sensor data and being at least one of a respiratory detection sensor, a motion sensor, an electrocardiogram (ECG), or a speed sensor; and(b) a second sensor configured to be mounted proximate to the horse so as to move with the horse, the second sensor outputting detected second sensor data, wherein the detected first and second data are both synchronized with respect to time.2. The equine physiological monitoring system of claim 1 , wherein the first sensor is a respiratory detection sensor outputting detected respiratory data and the second sensor is an imaging sensor outputting detected image data.3. The equine physiological monitoring system of claim 2 , further comprising an electrocardiogram (ECG) electrode configuration set configured to be mounted proximate to the horse so as to move with the horse claim 2 , the ECG electrode configuration set detecting and outputting detected cardiac data of the horse claim 2 , wherein the detected cardiac data is synchronized with respect to time with the respiratory data and the image data.4. The equine physiological monitoring system of claim 3 , further comprising a speed sensor configured to be mounted proximate to the horse so as to move with the horse claim 3 , the speed sensor outputting detected speed data claim 3 , wherein the detected speed data is synchronized with ...

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22-08-2013 дата публикации

Method for evaluating blush in myocardial tissue

Номер: US20130217985A1
Принадлежит: Novadaq Technologies ULC

Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.

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22-08-2013 дата публикации

Motion Tracking System with Inertial-Based Sensing Units

Номер: US20130217998A1
Принадлежит: JointVue, LLC

Systems, apparatus, and method of monitoring a position of a joint. An inertial monitoring unit is configured to be coupled to a portion of a patient, such as a thigh. Another inertial monitoring unit is configured to be attached to another portion of the patient, such as a shank, that is connected to the other portion by a joint, such as a knee. The inertial monitoring units detect motion of their respective portions of the patient and transmit data indicative of this motion. These transmissions may be received by a computer and used to determine an orientation of the joint. The inertial monitoring units may also be coupled to vibration detection units and/or ultrasound modules that provide additional data regarding a condition of the joint. 1. A joint monitoring apparatus comprising:a first inertial monitoring unit configured to be coupled to and detect motion of a first portion of a patient, and to collect and transmit data indicative of the detected motion; anda second inertial monitoring unit configured to be attached to and detect motion of a second portion of the patient, and to collect and transmit data indicative of the detected motion, whereinthe first portion of the patient is coupled to the second portion of the patient by the joint.2. The apparatus of further comprising:a first ultrasound module located in a fixed position with respect to the first inertial monitoring unit; anda second ultrasound module located in a fixed position with respect to the second inertial monitoring unit.3. The apparatus of wherein the ultrasound module includes:an ultrasound transducer that generates a signal in response to receiving an ultrasound echo within a receiving period, anda variable gain amplifier coupled to the ultrasound transducer, the variable gain amplifier being configured to dynamically adjust the gain applied to the signal generated by the ultrasound transducer based on the time the echo is received within the receiving period.4. The apparatus of wherein ...

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29-08-2013 дата публикации

Methods, Systems and Computer Program Products for Non-Invasive Determination of Blood Flow Distribution Using Speckle Imaging Techniques and Hemodynamic Modeling

Номер: US20130223705A1
Принадлежит: East Carolina University

A non-invasive method for measuring blood flow in principal vessels of a heart of a subject is provided. The method includes illuminating a region of interest in the heart with a coherent light source, wherein the coherent light source has a wavelength of from about 600 nm to about 1100 nm; sequentially acquiring at least two speckle images of the region of interest in the heart during a fixed time period, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject; and electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow rate in the principal vessels and quantify perfusion distribution in tissue in the region of interest in the heart from the LSCI image.

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05-09-2013 дата публикации

DEFORMABLE REGISTRATION FOR TISSUE ANALYTICS

Номер: US20130231548A1
Принадлежит: QI IMAGING, LLC

A tissue analysis system is disclosed. Tissue analysis systems include sensors that acquire signals originating from a target tissue and representative of a tissue property. A signal converter converts the signals to property measurements. An analysis engine can derive a variation of one tissue property with respect to another property and present the variation within a deformable registration imaging devices. 1. A tissue analysis system , comprising:at least one sensor configured to receive at least one signal representative of a first tissue property and a second tissue property of at least a portion of a target tissue;a signal converter coupled with the at least one sensor and configured to convert the at least one signal into a first property measurement of the first tissue property and a second property measurement of the second tissue property; anda deformable registration imaging device coupled with the signal converter and configured to present an image representative of a variation of the first tissue property relative to the second tissue property dependent on the first property measurement and the second property measurement.2. The system of claim 1 , wherein the at least one sensor comprises a sensor array.3. The system of claim 2 , wherein a first sensor receives a first signal representative of the first tissue property claim 2 , and a second different sensor receives a second signal representative of the second tissue property.4. The system of claim 1 , wherein the second property measurement comprises an observation time.5. The system of claim 4 , wherein the variation comprises a time derivative of the first tissue property with respect to the observation time.6. The system of claim 5 , wherein the time derivative comprises a velocity of the portion of the tissue.7. The system of claim 5 , wherein the time derivative comprises an acceleration of the portion of the tissue.8. The system of claim 5 , wherein the time derivative comprises a higher order ...

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05-09-2013 дата публикации

Implantable Radio-Frequency Sensor

Номер: US20130231550A1
Принадлежит: KYMA MEDICAL TECHNOLOGIES LTD.

Diagnostic apparatus () includes a sealed case (), including a biocompatible material and configured for implantation within a body of a human subject (). At least one antenna () is configured to be implanted in the body in proximity to a target tissue () and to receive radio frequency (RF) electromagnetic waves propagated through the target tissue and to output a signal in response to the received waves. Processing circuitry (), which is contained within the case, is coupled to receive and process the signal from the antenna so as to derive and output an indication of a characteristic of the target tissue 1. Diagnostic apparatus , comprising:a sealed case, comprising a biocompatible material and configured for implantation within a body of a human subject;at least one antenna, which is configured to be implanted in the body in proximity to a target tissue and to receive radio frequency (RF) electromagnetic waves propagated through the target tissue and to output a signal in response to the received waves; andprocessing circuitry, which is contained within the case and is coupled to receive and process the signal from the antenna so as to derive and output an indication of a characteristic of the target tissue.2. The apparatus according to claim 1 , wherein the at least one antenna is configured to transmit the waves into the body and to receive the transmitted waves following propagation of the waves through the target tissue.3. The apparatus according to claim 2 , wherein the at least one antenna is configured to receive the waves after reflection of the waves from a tissue in the body claim 2 , and wherein the processing circuitry is configured to detect a modulation of the reflection due to at least one of a heartbeat and a respiratory motion of the subject.4. The apparatus according to claim 3 , wherein the modulation comprises a cyclical variation due to the heartbeat.5. The apparatus according to claim 2 , and comprising a reflector configured for ...

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05-09-2013 дата публикации

Functional integration of virtual prosthesis in a tissue model

Номер: US20130231911A1
Принадлежит: Qi Imaging LLC

Systems and methods of integrating a virtual prosthesis with a tissue model are presented. Tissue characteristics and prosthesis characteristics can be leveraged to construct observable tissue models that present a model of mutual deformation, especially a time-varying mutual deformation, of a tissue and a possible prosthesis. The mutual deformation indicates how the tissue and prosthesis impact each other over time, possibly on a voxel-by-voxel basis based on deformable registration techniques.

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12-09-2013 дата публикации

Rib-protecting devices for thoracoscopic surgery, and related methods

Номер: US20130237766A1
Принадлежит: Physcient Inc

Methods and devices are disclosed to reduce tissue trauma when a surgeon performs surgery by thoracoscopy. Methods and devices are disclosed for protecting tissues adjacent to an intercostal incision from trauma caused by impingement of instruments into an intercostal incision. In one part, these methods and devices include devices that have controls that stick up out of the incision, permitting adjustment by the surgeon. In another part, methods and devices are disclosed for smaller devices that reside entirely under this skin and require no adjustment by the surgeon.

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12-09-2013 дата публикации

DEVICE AND METHOD FOR DETERMINING A BIOLOGICAL, CHEMICAL AND/OR PHYSICAL PARAMETER IN A LIVING BIOLOGICAL TISSUE

Номер: US20130237797A1
Принадлежит: Vivantum GmbH

The invention relates to a device for determining biological, chemical and/or physical parameters in living biological tissue, comprising an energy supply unit, a laser operating unit with at least one laser source directed at the biological tissue, at least one sensor unit for detecting the light scattered back and/or absorbed by the biological tissue, a control unit, a storing and processing unit and an interface for an external data processing unit. The method according to the invention includes execution of a calibrating phase for ascertaining a reference set (R) of reference vectors (Ri), in each case involving independently ascertaining a parameter (BZi), radiating unpolarized laser light onto the biological tissue and registering a measured value vector (Mi) from a series of optical measured variables and executing an interpolation phase for ascertaining an interpolation set (I) of interpolation vectors (Ik), in each case involving radiating unpolarized laser light onto the biological tissue and registering a measured value vector (Mk) from a back-scattered light intensity with a subsequent determination of an interpolated parameter (BKk) from the reference set (R). 1. A device for determining a biological , chemical and/or physical parameter in living biological tissue comprising{'b': 1', '1', '2', '3', '4', '5', '6', '7', '8, 'i': 'a', 'a central unit (), an energy supply unit (), a laser operating unit () for operating at least one laser source () directed onto the biological tissue, at least one sensor unit () for detecting light scattered back and/or absorbed by the biological tissue, a control unit (), a storing and processing unit (), and an interface () for an external data processing unit ().'}2. The device according to claim 1 ,characterized in that{'b': 4', '9', '10', '11, 'the sensor unit () includes a planar sensor array (), wherein the sensor array comprises a first sensor portion as an inner sub-array (), and a second sensor portion as an outer ...

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12-09-2013 дата публикации

Appliance for an Electromagnetic Spectrum Sensor Monitoring an Intravascular Infusion

Номер: US20130237812A1
Принадлежит: IVWATCH, LLC

An epidermal dressing includes an appliance for linking an electromagnetic spectrum sensor with a cannula administering an intravascular infusate. The appliance includes a body and a fitting coupled to the body. The body is configured to space a connector of the cannula from the epidermis. The fitting includes a first arrangement that is configured to retain the electromagnetic spectrum sensor for sensing the infusate in perivascular tissue, and a second arrangement that is configured to release the electromagnetic spectrum sensor from the first arrangement. 1. An appliance for a sensor configured to emit and detect near-infrared signals through an epidermis , the appliance comprising: a first arrangement configured to retain the sensor for monitoring fluid in perivascular tissue with the near-infrared signals; and', 'a second arrangement configured to release the sensor from the first arrangement;, 'a fitting including a chute extending along an axis between first and second ends, the fitting having'}a frame coupled to the fitting;a body at least partially covering the frame; and a panel coupled to the body; and', 'adhesive configured to bond the panel and the epidermis., 'a foundation configured in the first arrangement of the fitting to separate the sensor and the epidermis, the foundation including'}2. The appliance of wherein the body is configured to overlie a larger area of the epidermis than the second end of the chute.3. The appliance of wherein the fitting has a greater resistance to deformation than the body.4. The appliance of wherein the fitting has a greater resistance to deformation than the frame claim 3 , and the frame has a greater resistance to deformation than the body.5. The appliance of wherein the panel is configured to be approximately transparent to the near-infrared signals.6. The appliance of wherein the axis extends obliquely with respect to the panel.7. The appliance of wherein the frame comprises:a hoop at least partially disposed about ...

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19-09-2013 дата публикации

Adjustable Overlay Patterns for Medical Display

Номер: US20130245460A1
Принадлежит:

A system for identifying an area of interest on a surgical image, including a source of surgical image data, which may be a camera, an image processing unit, which may be a camera control unit, and a destination, which may be a display. The image processing unit is configured to receive the surgical image data and combine it with an overlay pattern for identifying an area of interest, which is then displayed on the display. The overlay pattern may include centric lines, concentric ovals, concentric circles, or other concentric shapes. The overlay may include a key with coordinates or labels. Properties of the overlay and the key may be customized and adjusted. 1. A system for identifying an area of interest on a surgical image , comprising:a source of surgical image data;an image processing unit in communication with said source;software executing on said image processing unit for combining said surgical image data with an overlay pattern selected from a group consisting of concentric shapes, centric lines, and a combination thereof for identifying an area of interest on said surgical image data;said software being further designed to configure at least one property of said overlay pattern; anda destination in communication with said image processing unit for receiving said surgical image data in combination with said overlay pattern, said destination comprising a display.2. The system of wherein said concentric shapes are concentric circles claim 1 , concentric ovals claim 1 , or concentric polygons.3. The system of wherein said concentric shapes are concentric circles.4. The system of wherein the diameters of at least two of said concentric circles are at 25% and 50% of the height of said display.5. The system of wherein said centric lines are shown for every 15 degrees claim 1 , 20 degrees claim 1 , 30 degrees claim 1 , 45 degrees claim 1 , 60 degrees claim 1 , or 90 degrees.6. The system of wherein said overlay pattern comprises concentric circles superimposed ...

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10-10-2013 дата публикации

Subject information obtaining apparatus and subject information obtaining method

Номер: US20130267820A1
Автор: Takuro Miyasato
Принадлежит: Canon Inc

A subject information obtaining apparatus includes a plurality of acoustic wave detection elements, each of which detects a photoacoustic wave generated when a subject is irradiated with light and outputs a detection signal, an initial-sound-pressure obtaining unit that obtains an initial sound pressure in a region of interest in the subject on the basis of the detection signals, a light-intensity obtaining unit that obtains a corrected light intensity in the region of interest on the basis of weighting coefficients based on sensitivity distributions of the acoustic wave detection elements and a light intensity of the light with which the region of interest is irradiated, and an optical-characteristic-value obtaining unit that obtains an optical characteristic value in the region of interest on the basis of the initial sound pressure and the corrected light intensity.

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10-10-2013 дата публикации

MEDICAL DEVICE AND METHOD FOR USE IN TISSUE CHARACTERIZATION AND TREATMENT

Номер: US20130267821A1
Принадлежит: DUNE MEDICAL DEVICES LTD.

A medical device is presented for use in tissue characterization and treatment. The device comprises a tissue characterization probe comprising an elongated carrier carrying an array of tissue characterization sensors which are arranged in a spaced-apart relationship on at least a part of the carrier with known distances between them along a longitudinal axis of the carrier and along at least part of a circumference of the carrier, such that during progression of the probe through a tissue mass each of the sensors generates tissue characterization signals from successive locations thereof within the tissue mass enabling to locate an abnormal tissue inside said tissue mass, thereby enabling consequent treatment of the abnormal tissue. Several movement mechanisms are described for enabling relative movement between the carrier and a treatment tool passing therethrough. 1. A medical device for use in tissue characterization and treatment , the device comprising:a tissue characterization probe comprising an elongated carrier carrying an array of tissue characterization sensors which are arranged in a spaced-apart relationship on at least a part of the carrier with known distances between them along a longitudinal axis of said carrier and along at least part of a circumference of the carrier, such that during progression of the probe through a tissue mass each of the sensors generates tissue characterization signals from successive locations thereof within the tissue mass enabling to locate an abnormal tissue inside said tissue mass thereby enabling consequent treatment of the abnormal tissue.2. The device according to claim 1 , wherein the array of tissue characterization sensors are arranged in at least one circular part along the circumference of the carrier.3. The device according to claim 1 , wherein said elongated carrier has two integral portions including a distal portion and a hollow portion extending between a proximal end of the carrier and said distal portion ...

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31-10-2013 дата публикации

System, Method and Applications Involving Identification of Biological Circuits Such as Neurological Characteristics

Номер: US20130284920A1
Принадлежит: Leland Stanford Junior University

Various aspects are directed to systems and methods for assessing neural activity of a neural region having multiple subfields. In certain embodiments, a method includes evoking a cellular electrical response in at least one subfield due to neural activity in the neural region, capturing image data of the electrical response at a level sufficiently detailed in space and time to differentiate between polarization-based events of two respective portions of the subfield, and then assessing neural activity by correlating space and time information, from the captured data, for the two respective portions of the sub-field. Other more specific aspects of the invention involve different preparation and neural stimulation approaches which can vary depending on the application.

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31-10-2013 дата публикации

INFRARED GUIDE STARS FOR ENDOSCOPIC ORIENTEERING

Номер: US20130289362A1
Принадлежит: EMPIRE TECHNOLOGY DEVELOPMENT LLC

Briefly stated, technologies are generally described for tracking a location and an orientation of a medical tool inside a body. The method may include positioning multiple light emitting diodes (LEDs) in infrared (IR) wavelength range near a tip of the medical tool. Upon insertion of the medical tool inside the body, the LEDs may emit IR light in unique patterns, which may be detectable through bodily tissue. The emitted light patterns may be detected through an IR detector device external to the body. One or more IR markers may be placed near the body to serve as reference points and the IR detector may determine the location and the orientation of the medical tool inside the body based on the detected light patterns. The location and the orientation of the medical tool inside the body may be displayed on a monitor. 1. A method for tracking a location of a medical tool inside a body , the method comprising: positioning a first set of at least three LEDs along a circumference of the tip of the medical tool, and', 'positioning a second set of at least three LEDs on an outside surface of the medical tool about one wavelength away from the tip of the medical tool;, 'positioning a plurality of light emitting diodes (LEDs) in infrared (IR) wavelength range near a tip of the medical tool byupon insertion of the medical tool inside the body, causing the LEDs to emit IR light with each LED emitting according to a predefined pattern;detecting the emitted light patterns through an IR detector device external to the body; anddetermining a location and an orientation of the medical tool inside the body based on the detected light patterns.2. The method according to claim 1 , further comprising:employing the medical tool for at least one from a set of: enteroscopy, esophagogastroduodenoscopy, colonoscopy, sigmoidoscopy, endoscopic retrograde cholangiopancreatography, duodenoscope-assisted cholangiopancreatoscopy, anoscopy, proctoscopy, rectoscopy, bronchoscopy, otoscopy, ...

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31-10-2013 дата публикации

Enhanced therapeutic stimulus system and methods of use

Номер: US20130289648A1
Принадлежит: Individual

The present invention relates to a therapeutic system and methods of using the therapeutic system. In particular, the present invention relates to systems having hardware, software, and appliance components for assessing and entraining a neuromuscular pattern or behavior in a patient. The methods include configuring the hardware and software systems to receive data from an orofacial stimulation appliance and to generate a precise therapeutic pulse profile that is actuated as a tactile stimulus. In one embodiment, the system and methods also include collecting data using the orofacial stimulation appliance and delivering the tactile stimulus via the orofacial stimulation appliance to entrain an organized neuromuscular pattern or behavior.

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07-11-2013 дата публикации

DIGITAL LIGHT PROCESSING HYPERSPECTRAL IMAGING APPARATUS

Номер: US20130296708A1
Принадлежит:

A hyperspectral imaging system having an optical path. The system including an illumination source adapted to output a light beam, the light beam illuminating a target, a dispersing element arranged in the optical path and adapted to separate the light beam into a plurality of wavelengths, a digital micromirror array adapted to tune the plurality of wavelengths into a spectrum, an optical device having a detector and adapted to collect the spectrum reflected from the target and arranged in the optical path and a processor operatively connected to and adapted to control at least one of: the illumination source; the dispersing element; the digital micromirror array; the optical device; and, the detector, the processor further adapted to output a hyperspectral image of the target. The dispersing element is arranged between the illumination source and the digital micromirror array, the digital micromirror array is arranged to transmit the spectrum to the target and the optical device is arranged in the optical path after the target. 131-. (canceled)32: A method for obtaining spectral image data from a target in vivo comprising the steps of:generating a beam of light;dispersing said light beam with a dispersing element;separating said dispersed light beam into at least one spectrum using a spatial light modulator;illuminating said target with said at least one spectrum, wherein said at least one spectrum subsequently reflects off of said target as at least one reflected light beam;collecting said at least one reflected light beam; and,directing said at least one collected reflected light beam to a detector adapted to capture at least one spectral image data.33: The method according to claim 32 , further comprising the steps of:tuning said spatial light modulator;triggering said detector for collecting said at least one reflected light beam;forming a hyperspectral image from said at least one spectral image data and,displaying said hyperspectral image on a display device. ...

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28-11-2013 дата публикации

DEVICES, SYSTEMS, AND METHODS FOR VIRTUAL STAINING

Номер: US20130317369A1
Принадлежит: Genetic Innovations, Inc.

The disclosure herein provides methods, systems, and devices for virtually staining biological tissue for enhanced visualization without use of an actual dye or tag by detecting how each pixel of an unstained tissue image changes in waveform after staining with a certain dye(s) and/or tag(s) or other transformation under a certain electromagnetic radiation source, developing a virtual staining transform based on such detection, and applying such virtual staining transform to an unstained biological tissue to virtually stain the tissue. 1. An apparatus for providing medical therapy to an in vivo tissue sample , the apparatus comprising:a medical probe having a virtual staining device configured to provide in vivo virtual staining of the in vivo tissue sample, the virtual staining device comprising an electromagnetic radiation source for directing an electromagnetic radiation at the tissue sample, and a detector for detecting electromagnetic radiation reflected or transmitted from the tissue sample,a communication interface configured to provide communication between the electromagnetic radiation source and a computer system, or the detector and the computer system;an initial image generation module of the computer system configured to generate an input image from the detected electromagnetic radiation from the tissue sample, wherein the first image comprises a plurality of pixels;a virtual staining module of the computer system configured to assign a virtual stain to the input image of the in vivo tissue sample based on an identified waveform associated with each one of a plurality of pixels forming the input image; anda therapeutic element configured to provide the medical therapy to the tissue sample based at least in part on the virtual stain.2. The apparatus of claim 1 , wherein the therapeutic element is incorporated into the medical probe.366-. (canceled)67. A computer-implemented method for virtually staining a tissue sample claim 1 , the computer-implemented ...

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05-12-2013 дата публикации

MOLECULAR PROBES FOR MULTIMODALITY IMAGING OF ANIONIC MEMBRANE SURFACES

Номер: US20130323172A1
Принадлежит:

Embodiments provide dual modality probes for imaging phosphatidylserine (PS) exposure and other anionic membrane surfaces. In various embodiments, the probes were constructed by utilizing a) the high selectivity of synthetic zinc (II) dipicolylamine coordination complexes (Zn-DPA) for targeting externalized PS which over-expresses in apoptotic and necrotic cells, b) a near-infrared (NIR) dye for optical imaging, and c) a widely used clinically approved radionuclide for PET (or SPECT) imaging. A variety of linking elements were incorporated into the probes between the Zn-DPA and radionuclide motif to modulate the pharmacokinetics. The in vitro and in vivo data of radiolabeled dipicolylamine probes demonstrated their utilities for imaging PS exposure with multiple imaging modalities. 1. A dual-modality pharmaceutical compound comprising:a fluorescent entity (F);a radioactive entity (R); andan anionic surface targeting entity (Z).2. The dual-modality pharmaceutical compound of claim 1 , further comprising a linker entity (Y).3. The dual-modality pharmaceutical compound of claim 2 , wherein the compound has the structure:(F)—(R)—(Y)—Z.4. The dual-modality pharmaceutical compound of claim 1 , wherein the anionic surface targeting entity (Z) is substituted with a metal ion.5. The dual-modality pharmaceutical compound of claim 4 , wherein the metal ion is zinc or copper.6. The dual-modality pharmaceutical compound of claim 1 , wherein the fluorescent entity (F) has an emission max range of 440-900 nm and an absorbance max range of 380-880 nm.7. The dual-modality pharmaceutical compound of claim 6 , wherein the fluorescent entity (F) is a fluorescein claim 6 , a rhodamine claim 6 , BODIPY claim 6 , Cy-3 claim 6 , Cy-5 claim 6 , Cy-7 claim 6 , a squaraine rotaxane claim 6 , an NIR dye claim 6 , or a derivative thereof.8. The dual-modality pharmaceutical compound of claim 1 , wherein the radioactive entity (R) is a radionuclide.9. The dual-modality pharmaceutical compound of ...

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19-12-2013 дата публикации

DEVICE FOR MONITORING A MEDICAL PROSTHESIS AND THE HUMAN BODY

Номер: US20130338455A1
Принадлежит:

A device for monitoring a medical prosthesis and the human body includes a sensor for generating signals depending on surrounding stresses, a processor for processing the signals emitted by the sensor in order to convert the signals into data, a storage device for storing the data, a device for wireless transmission of the stored data, and a supply of electrical energy. The device is included in at least one casing, which is made of biocompatible material and has a device for fixing to a bone. 11. A device () for monitoring a medical prosthesis and the human body , comprising:{'b': '2', 'sensor means (), capable of generating signals according to surrounding stresses,'}{'b': 3', '2, 'processing means (), capable of processing the signals transmitted by the sensor means () to convert them into data,'}{'b': '4', 'storage means (), capable of storing the data,'}{'b': '5', 'means () for wirelessly transmitting the stored data,'}{'b': '6', 'electrical energy power supply means (),'}{'b': 2', '3', '4', '5', '6', '7, 'in which said sensor (), processing (), storage (), transmission () and power supply () means are included in at least one housing () made of biocompatible material,'}{'b': 7', '8', '14', '19', '16', '8, 'wherein said at least one housing () is secured reversibly to fixing means (, , ) by locking means (), said fixing means () being intended and designed to be fixed to a bone.'}2177070071313a. The device () as claimed in claim 1 , wherein said at least one housing ( claim 1 , claim 1 , ) comprises a face () intended to bear against the bone () by means of a shaping adapted to the external shape of the bone ().3112. The device () as claimed in claim 1 , comprising a shim () comprising:{'b': 12', '13', '13, 'i': 'a', 'a first face () intended to bear against the bone () by means of a shaping adapted to the external shape of the bone (),'}{'b': 12', '12', '7', '7', '70', '700', '7', '7', '70', '700, 'i': b', 'a', 'a', 'a, 'a second face (), substantially ...

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19-12-2013 дата публикации

System and Method for Mitigating the Effects of Tissue Blood Volume Changes to Aid in Diagnosing Infiltration or Extravasation in Animalia Tissue

Номер: US20130338512A1
Принадлежит: IVWatch LLC

A system including a sensor and a device coupled to the sensor. The sensor is configured to detect in Animalia tissue (i) a first electromagnetic radiation extinction dominated by absorption of a first wavelength and (ii) a second electromagnetic radiation extinction dominated by scattering of a second wavelength. The device is configured to aid in diagnosing at least one of infiltration and extravasation in the Animalia tissue based on the first and second electromagnetic radiation extinctions detected by the sensor.

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26-12-2013 дата публикации

PRESSURE SENSOR

Номер: US20130345598A1
Принадлежит: SFH OXFORD LIMITED

A sensor suitable for measuring the pressure applied by a bandage, the sensor being in the form of an elongate strip having a plurality of pads arranged along its length, wherein the sensor includes a connection to each pad, whereby the pressure applied to each pad can be determined independently, wherein each pad is inflatable to form an expanded pad protruding above the surface of the strip, and deflatable so that it does not impede removal of the sensor from the bandage. Such a sensor is primarily intended for single use, i.e. is disposable. 1. A sensor suitable for measuring the pressure applied by a bandage , the sensor being in the form of an elongate strip having a plurality of pads arranged along its length , wherein the sensor includes a connection to each pad , whereby the pressure applied to each pad can be determined independently , wherein each pad is inflatable to form an expanded pad protruding above the surface of the strip , and deflatable so that it does not impede removal of the sensor from the bandage.2. The sensor according to claim 1 , wherein each pad includes a strain gauge.3. The sensor according to claim 1 , wherein each pad includes means whereby the capacitance varies according to its inflation.4. The sensor according to claim 1 , wherein each pad includes an optical sensor.5. The sensor according to claim 1 , which comprises a conduit to each pad and a member providing a connection to a source of pressure claim 1 , whereby each pad is independently inflatable.6. A combination of a sensor according to and claim 1 , connected or connectable thereto claim 1 , means for determining the pressure applied to each pad.7. A combination of a sensor according to and claim 5 , connected or connectable thereto claim 5 , means whereby the pads can be inflated and deflated under negative pressure claim 5 , and means for determining the pressure applied to each pad.8. A sterile pack containing a sensor according to .9. A method for testing the ...

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09-01-2014 дата публикации

Systems and Methods for Combining Hyperspectral Images with Color Images

Номер: US20140012135A1
Принадлежит: Hypermed Imaging, Inc.

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease and cancer, that incorporate hyperspectral or multispectral imaging. 129-. (canceled)30. A method of obtaining information about a region of interest of a subject , the method comprising:a) resolving light obtained from the region of interest of the subject into a plurality of component spectral bands;b) constructing a pseudo color spectral image based on the plurality of component spectral bands; andc) combining the pseudo color spectral image with a color photo image of the area of the region of interest to form a composite image.31. The method of claim 30 , wherein a wavelength range of each respective component spectral band in the plurality of component spectral bands is adjacent to the wavelength range of another component spectral band in the plurality of component spectral bands.32. The method of claim 30 , wherein each respective component spectral band in the plurality of component spectral bands has a bandwidth of less than 50 nm.33. The method of claim 30 , wherein each respective component spectral band in the plurality of component spectral bands has a bandwidth that is between 10 nm and 40 nm.34. The method of claim 30 , wherein each respective component spectral band in the plurality of component spectral bands has a bandwidth that is between 10 nm and 15 nm.35. The method of claim 30 , wherein each respective component spectral band in the plurality of component spectral bands has a bandwidth that is between 5 nm and 12 nm.36. The method of claim 30 , the method further comprising displaying the composite image on a computer screen.37. The method of claim 30 , wherein the region of interest of the subject is a portion of the skin of the ...

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09-01-2014 дата публикации

Biological Optical Measuring Apparatus

Номер: US20140012136A1
Принадлежит:

A biological optical measuring apparatus includes a light source probe and a light receiving probe, one of which is provided with a pressure sensor to detect a contact pressure of a skin of a subject. Pairs of plural values of the contact pressure and light detection signals are previously recorded as calibration data, an estimated value of a false signal is derived from a detection value of the pressure sensor at primary measurement and the calibration data, and a measurement signal waveform in which a noise component due to a movement of the subject is removed is acquired by subtracting the estimated value from a light measurement signal. 1. A biological optical measuring apparatus comprising:a light source probe which is applied to a measurement object and includes a mechanism to bring a first light guide as a passage of an irradiation light from a light source into press contact with a skin of the measurement object;a light receiving probe which is applied to the measurement object and includes a mechanism to bring a second light guide as a passage of a light from the measurement object to the light receiving sensor into press contact with the skin of the measurement object;a measurement control circuit which controls driving of the light source and captures a light detection signal from the light receiving probe, in which inner information of the measurement object is measured from an intensity change of the light scattered and transmitted through an inside of the measurement object;a pressure sensor which is provided in at least one of the light source probe and the light receiving probe and detects a contact pressure between the measurement object and one of the first light guide and the second light guide; anda data recording control device which correlates values of light detection signals of the light receiving sensor with a plurality of values of the contact pressures obtained from the pressure sensor at a time of previous calibration measurement, records ...

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16-01-2014 дата публикации

Holder set and brain function measuring device using same

Номер: US20140018640A1
Принадлежит: Shimadzu Corp

This holder set is provided with: an optical bioinstrumentation holder which has at least two probe mounting units into which are inserted light-transmitting probes which irradiate light from the tip, or light-receiving probes which receive light from the tip, and which is mounted on the subject's head; and a electroencephalograph holder which has at least one electrode mounting unit into which an EEG electrode is inserted which detects the potential difference with a reference electrode. This optical bioinstrumentation holder is provided with a linear trunk unit extending in a first direction, and at least two linear branches extending in a second direction different from the first direction, and the electroencephalograph holder is provided with a linear trunk unit extending in a first direction, and at least one linear branch extending in the direction opposite to said second direction.

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30-01-2014 дата публикации

SYSTEM AND METHOD FOR QUANTITATIVELY ASSESSING DIABETIC CARDIAC AUTONOMIC NEUROPATHY IN TYPE I DIABETIC BIOLOGICAL SUBJECT

Номер: US20140031651A1
Автор: Chon Ki H.
Принадлежит:

The present disclosure provides a method and an apparatus for identifying development of diabetic cardiovascular autonomic neuropathy (DCAN) in a biological subject. In one aspect, the method includes collecting data associated with heart rates of a biological subject, and processing the collected data to extract primary and secondary components of the collected data by performing a principal dynamic mode (PDM) analysis. A significant reduction of the primary or secondary component at a predetermined time period can be indicative of the DCAN development. 1. A method for identifying development of diabetic cardiovascular autonomic neuropathy (DCAN) in a biological subject , the method comprising:collecting data associated with heart rates of a biological subject; andprocessing the collected data to extract primary and secondary components of the collected data by performing a principal dynamic mode (PDM) analysis;determine whether there is a significant reduction of the primary or secondary component at a predetermined time period;wherein the significant reduction of the primary or secondary component at the predetermined time period is indicative of the DCAN development.2. The method of claim 1 , wherein the primary and secondary components respectively represent sympathetic and parasympathetic dynamics of an autonomic nervous system of the biological subject.3. The method of claim 1 , wherein collecting the data comprises monitoring pulsatile signals associated with the heart rates of the biological subject by detecting an optical property associated with a biological fluid of the biological subject using an imaging device of a portable communication device.4. The method of claim 1 , wherein collecting the data comprises monitoring pulsatile signals associated with the heart rates of the biological subject by using an electrocardiography (ECG) device.5. The method of claim 1 , wherein processing the collected data comprises using a computing device to:detrend the ...

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06-02-2014 дата публикации

Optical Measuring Device

Номер: US20140039284A1
Принадлежит:

An accurate measurement can be made of the light absorbance of deep layer tissue such as in a human body or a fruit. The thickness of fat is computed. A first specific distance and a second specific distance corresponding to the computed fat thickness are computed based a predetermined relationship between the fat thickness, the first specific distance, and measurement sensitivity of a surface layer and measurement sensitivity of a deep layer when light is received at a position the first specific distance away from a light emitting means. A third specific distance and a fourth specific distance are computed corresponding to the computed fat thickness based on a predetermined relationship between the fat thickness, the third specific distance and a measurement sensitivity of an intervening layer and a measurement sensitivity of the deep layer when light is received at a position the third specific distance away from the light emitting means. 1. An optical measuring device comprising:a light emitting unit that illuminates light of each of two different wavelengths onto a human body formed from a plurality of layers including a uterine muscle layer, and skin and fat layer;an acquisition unit that acquires a thickness of the skin and fat layer;a first computation unit that computes a first specific distance corresponding to the acquired thickness of the skin and fat layer based on a predetermined relationship between the thickness of the skin and fat layer, the first specific distance, and a measurement sensitivity of the skin and a measurement sensitivity of the uterine muscle layer when light from the light emitting unit is received at a position the first specific distance away from the light emitting unit; anda second computation unit that computes a second specific distance corresponding to the acquired thickness of the skin and fat layer based on a predetermined relationship between the thickness of the skin and fat layer, the second specific distance, and a ...

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13-02-2014 дата публикации

Coherence Gated Doppler Motion Sensor and Medical Applications

Номер: US20140043618A1
Принадлежит:

A motion sensor applicable to medical procedures includes a source of light with a wavelength bandwidth and an optical detector. A first optical coupler terminates in a first probe tip and couples the light into the first probe tip. A second optical coupler terminates in a second probe tip and directs onto the detector scattered light returning through the second probe tip. A presentation device outputs a signal that indicates motion in a target volume of a sample in a vicinity of the probe tips based on a Doppler shift of the scattered light. The volume depends on coherence distance determined by the bandwidth. In variations, the first and second tips are the same tip, a multimode fiber is included, the bandwidth is between 0.1% and 5% of a center wavelength, or the presentation device is a speaker, or some combination. 1. An apparatus comprising:an optical source of light comprising a band of wavelengths;an optical detector;a first optical coupler configured to direct light from the optical source through an emission optical path that terminates at a distal end in a single probe tip;a second optical coupler configured to direct onto the optical detector scattered light returning from the single probe tip through a return optical path;a presentation device configured to output a signal that indicates motion in a target volume of a sample in a vicinity of the single probe tip based on a Doppler shift between the light from the light source and the scattered light received at the detector through the single probe tip,wherein the target volume is based on a coherence distance determined by a bandwidth of the band of wavelengths of the light from the optical source.2. An apparatus as recited in claim 1 , wherein the first optical coupler and second optical coupler includes a single optical fiber connected to the single probe tip claim 1 , and the single optical fiber is multimode fiber.3. An apparatus as recited in claim 1 , wherein the bandwidth is in a range from ...

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13-02-2014 дата публикации

ULTRASOUND VIBROMETRY WITH UNFOCUSED ULTRASOUND

Номер: US20140046173A1
Принадлежит:

Methods for measuring mechanical properties of an object or subject under examination with an ultrasound system and using unfocused ultrasound energy are provided. Shear waves that propagate in the object or subject are produced by applying unfocused ultrasound energy to the object or subject, and measurement data is acquired by applying focused or unfocused ultrasound energy to at least one location in the object or subject at which shear waves are present Mechanical properties are then calculated from the acquired measurement data. 1. A method for measuring a mechanical property of a subject with an ultrasound system , the steps of the method comprising:a) producing shear waves that propagate in the subject by applying unfocused ultrasound energy to the subject;b) acquiring measurement data by using an detection device to measure at least one location in the subject in which the shear waves produced in step a) are present;c) calculating a mechanical property of the subject using the measurement data acquired in step b).2. The method as recited in in which the detection device is an ultrasound device and the measurement data is acquired in step b) by applying ultrasound energy to the at least one location in the subject.3. The method as recited in in which the ultrasound energy applied in step b) is at least one of focused ultrasound energy and unfocused ultrasound energy.4. The method as recited in in which the detection device is at least one of an optical detection device claim 1 , a magnetic resonance imaging device claim 1 , and a microwave detection device claim 1 , and the measurement data is acquired in step b) by applying electromagnetic energy to the at least one location in the subject.5. The method as recited in in which the unfocused ultrasound energy applied to the subject in step a) includes a plurality of unfocused ultrasound beams extending outward from an ultrasound transducer in a comb-shaped pattern.6. The method as recited in in which the ...

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13-02-2014 дата публикации

CONTACTLESS SLEEP DISORDER SCREENING SYSTEM

Номер: US20140046184A1
Принадлежит: KONINKLIJKE PHILIPS N.V.

Provided are systems () and methods () for providing contact-less sleep disorder diagnosis, including a sound input device () and/or a movement detector () that receive sound and/or movement data originating from a patient in a sleeping environment, respectively. Also included is a computer-implemented device () that receives and stores the sound and/or movement data and determines a sleep disorder diagnosis based on the received data. 1. A system for providing sleep disorder diagnosis comprising:a sound input device that receives sound originating from a patient in a sleeping environment;a movement detector that monitors movement of the patient in the sleeping environment; and receive and store data relating to the sound originating from the patient,', 'receive and store data relating to the movement of the patient, and', 'determine a sleep disorder diagnosis based on one or more of the data relating to the sound originating from the patient or the data relating to the movement of the patient., 'a computer-implemented device configured to2. The system claim 1 , wherein the movement detector is one or more of a visible light detecting camera claim 1 , a radar device claim 1 , an infrared light detecting camera claim 1 , an ultrasound device claim 1 , or a heat detecting camera.3. The system of claim 1 , wherein neither the sound input device or the movement detector is in contact with the patient when sound is received or movement is monitored.4. The system of claim 1 , wherein at least one of the sound input device or the movement detector is integrated into a housing with the computer-implemented device.5. The system of claim 1 , wherein the determination of the sleep disorder diagnosis includes a probability indicator for the diagnosis.6. A method for providing sleep disorder diagnosis comprising:receiving, at a sound input device sound originating from a patient in a sleeping environment;monitoring, at a movement detector, movement of the patient in the sleeping ...

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13-02-2014 дата публикации

IN VIVO BIOLUMINESCENCE MONITORING APPARATUS

Номер: US20140046195A1
Принадлежит: UNIVERSITE DE GENEVE

Apparatus for real-time in vivo bioluminescence monitoring in a conscious small animal, comprising a light-tight enclosure () with a base (), side wall () and cover () configured for housing the small animal such that it may move freely, a bioluminescence detector system () comprising a light detector () for detecting the light emitted by said small animal connected to a data processing system, and a life sustaining system () configured for maintaining the small animal alive for a prolonged period of time spanning from a few days to a few weeks. 121-. (canceled)2241619206228242216. An apparatus for real-time in vivo bioluminescence monitoring in a conscious small animal , comprising a light-tight enclosure () comprising a base () , side wall () and cover () configured for housing the small animal such that it may move freely , a bioluminescence detector system () comprising a light detector () for detecting the light emitted by said small animal connected to a data processing system , and a life-sustaining system () configured for maintaining the small animal alive for a prolonged period of time spanning from a few days to a few weeks , wherein the apparatus further comprises a light funneling device comprising a light funneling member () that extends from the light detector () in a diverging manner towards the base ().23832. The apparatus according to claim 22 , wherein the life sustaining system () comprises a remotely controllable ventilation system () connected to the data processing system.24. The apparatus according to claim 22 , wherein the apparatus comprises a temperature sensor configured to measure the environmental temperature in the light-tight enclosure and a heat exchanger connected to the data processing system and configured to control the environmental temperature in the light-tight enclosure.25834. The apparatus according to claim 22 , wherein the life sustaining system () comprises a remotely controllable source of light () connected to the data ...

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13-02-2014 дата публикации

Optical Speculum

Номер: US20140046311A1
Принадлежит: Illumigyn Ltd

A system for direct imaging and diagnosing of abnormal cells in a target tissue includes a disposable optical speculum and an image acquisition system having the speculum assembled on and mechanically secured thereto. The image acquisition system is arranged to capture at least one of a single image or multiple images or video of cells within the target tissue using at least one of bright field or dark field ring illumination divided into independently operated segments to obtain a plurality of data sets. An image analysis and control unit in communication with the image acquisition system analyzes the data sets and applies algorithms to the data sets for diagnosing abnormal cells.

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20-02-2014 дата публикации

Expanded frequency electroencephalography/electrocardiography light apparatus and method of use

Номер: US20140051945A1
Принадлежит: Terra Cotta Star LLC

The invention is an apparatus and method that measures expanded frequencies of electromagnetic activity in a user's brain and heart. The apparatus includes a computer, a display screen, a software program for rapid measurement and digital display of the users electromagnetic brain and heart frequencies above about 500 Hz, a plurality of EEG sensors and an EKG sensor that are connected to the computer.

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20-02-2014 дата публикации

Apparatus for physiological and environmental monitoring with optical and footstep sensors

Номер: US20140051948A1
Принадлежит: Valencell, Inc.

Wearable apparatus for monitoring various physiological and environmental factors are provided. Real-time, noninvasive health and environmental monitors include a plurality of compact sensors integrated within small, low-profile devices, such as earpiece modules. Physiological and environmental data is collected and wirelessly transmitted into a wireless network, where the data is stored and/or processed.

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20-02-2014 дата публикации

METHOD AND APPARATUS FOR MEDICAL DIAGNOSIS

Номер: US20140052026A1

The present disclosure includes a medical device which can assist in detecting tissue stiffness. For example, the present disclosure includes a medical device which can detect tissue stiffness associated with cancerous tissue for detecting cancer in a patient. In addition, the medical device of the present disclosure can be used for conducting a clinical breast exam. 1. A medical device comprising:a glove body configured to fit over a hand of a user and at least one force sensor secured to at least one fingertip of the glove body;a displacement assessment device configured to collect data indicating displacement of at least one fingertip as it is pressed against tissue in order to determine the stiffness of the tissue; anda processor configured to process data obtained by the displacement assessment device and the at least one force sensor to assess the stiffness of the tissue in contact with the at least one force sensor.2. The medical device of claim 1 , wherein the displacement assessment device is a camera.3. The medical device of claim 2 , wherein the camera is coupled to the glove body.4. The medical device of claim 1 , wherein the displacement assessment device is a circumferential pressure sensor array.5. The medical device of claim 4 , wherein the circumferential pressure sensor array is located along at least one fingertip of the glove body and is comprised of a plurality of pressure sensors positioned a defined distance apart in a circumferential arrangement relative to the fingertip.6. The medical device of claim 5 , wherein the pressure sensors include piezoelectric and resistive transducers.7. The medical device of claim 5 , wherein the processor determines the displacement of the finger against the tissue by evaluating the number of pressure sensors that are in contact with the tissue and the displacement between each pressure sensor.8. The medical device of claim 4 , wherein the circumferential pressure sensor array is comprised of concentric rings ...

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13-03-2014 дата публикации

Methods and Devices for Real Time Monitoring of Collagen Content and for Altering Collagen Status

Номер: US20140073901A1
Принадлежит: Alpha Orthopaedics, Inc.

The present invention comprises methods and systems/devices for non-invasively measuring and/or altering collagen structures before, during and after treatment, e.g., by the application of RF energy, of tissues that comprise such collagen structures. 1. A sensor system for monitoring collagen content and/or collagen status in one or more tissues , the system comprising:a signal generator which generates a signal to be transmitted to one or more tissues, which signal can be related to collagen content and/or collagen status in the one or more tissues;a connector operably connected to the signal generator, which connector carries the signal from the signal generator to the one or more tissues and which receives one or more signals back from the one or more tissues; and,a monitor which is operably connected to the connector, and which generates an output derived from the one or more signals back from the one or more tissues which corresponds to the collagen content and/or collagen status in the one or more tissues.233-. (canceled)34. A method of measuring collagen content and/or collagen status in one or more tissues in a subject , the method comprising:providing a signal generator which generates a signal to be transmitted to one or more tissues, which signal can be corresponded to collagen content and/or collagen status in the one or more tissues;providing a connector operably connected to the signal generator, which connector carries the signal from the signal generator to the one or more tissues and which receives one or more signals back from the one or more tissues;providing a monitor which is operably connected to the connector and/or signal generator, and which generates an output derived from the one or more signals back from the one or more tissues which corresponds to the collagen content and/or collagen status in the one or more tissues;inserting at least a portion of signal generator and/or the connector into a cavity of the subject such that at least a ...

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13-03-2014 дата публикации

METHOD AND APPARATUS FOR MONITORING AND ABLATING NERVES

Номер: US20140073903A1
Принадлежит:

Described herein is an apparatus for locally monitoring nerve activity that may be incorporated into a nerve ablation catheter. Such a catheter is equipped with magnetic sensing for both identifying nerves and assessing the success of the ablation. The catheter is also equipped with an ablation instrument for both stimulating and destroying nerve tissue. 1. A method for monitoring nerve activity , comprising:disposing a vapor cell containing a sensor gas adjacent selected nerve tissue;transmitting light to the vapor cell and receiving light reflected therefrom;controlling the light transmission so that the vapor cell operates as a light-storage magnetometer with the reflected light having a frequency component that corresponds to the magnitude of the magnetic field at the location of the sensor gas;processing the received light to measure the magnetic field at the location of the sensor gas;analyzing the time course of the measured magnetic field to determine if the selected nervous tissue is active.2. The method of further comprising stimulating the selected nervous tissue and determining whether the stimulation resulted in nervous activity.3. The method of further comprising:operating an ablation instrument adjacent the selected nervous tissue, where the ablation instrument may be operated in either a low-power stimulation mode that stimulates the nervous tissue or a high-power ablation mode that destroys the nervous tissue;stimulating the selected nervous tissue with the ablation instrument in stimulation mode; and,if the stimulation results in nervous activity, switching the ablation instrument to ablation mode to destroy the selected nervous tissue.4. The method of further comprising determining whether the stimulation resulted in nervous activity by correlating the measured magnetic field with the time at which the stimulation was delivered.5. The method of wherein the vapor cell is incorporated into a catheter with fiber optic cable running through one or ...

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13-03-2014 дата публикации

SYSTEM AND METHOD FOR DETERMINING A MEASURE OF THE RESISTANCE OF PERIPHERAL VASCULATURE

Номер: US20140073931A1
Принадлежит:

A system for determining the resistance of peripheral vasculature including a sensor configured to generate output signals proportional to the amount of blood in the peripheral vasculature over time, and a computer subsystem configured to determine the resistance of the peripheral vasculature in response to the output signals. 1. A system for determining the resistance of peripheral vasculature comprising:a sensor configured to generate output signals proportional to the amount of blood in the peripheral vasculature of a predetermined body part over time; anda computer subsystem configured to determine the resistance of the peripheral vasculature in response to the output signals.2. The system of in which the sensor is configured to emit light in the near-infrared or infrared spectra to peripheral vasculature in the predetermined body part and measure the light absorbed by the peripheral vasculature to generate the output signal proportional to the amount of blood in the peripheral vasculature over time.3. The system of in which the sensor is configured to measure the pressure in the predetermined body part by generating the output signals proportional to the amount of blood in the peripheral vasculature.4. The system of in which the predetermined body part includes a finger claim 1 , thumb claim 1 , hand claim 1 , arm claim 1 , abdomen claim 1 , foot claim 1 , or a body part directly associated with the peripheral vasculature.5. The system of in which the computer subsystem includes an algorithm configured to calculate the resistance of the peripheral vasculature.6. The system of in which the algorithm is configured to round the calculated resistance of peripheral vasculature to an integer between 0 and 10.7. The system of further including a display device coupled to the computer system configured to display the resistance of the peripheral vasculature.8. The system of in which the display device is configured to display an integer rounded from the calculated ...

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20-03-2014 дата публикации

Acoustic wave receiving apparatus

Номер: US20140076055A1
Принадлежит: Canon Inc

Use of an acoustic wave receiving apparatus which includes: a resonator including a first mirror on which measurement light is incident, a second mirror which is arranged to face the first mirror and on which acoustic waves from an object are incident, an acoustic wave reception layer interposed between the first mirror and the second mirror, and a compensation layer; and a detector for detecting a variation in an optical path length between the first mirror and the second mirror that occurs in response to deformation of the acoustic wave reception layer caused by incidence of the acoustic waves, wherein the variation in the optical path length due to a film thickness distribution of the acoustic wave reception layer is compensated by refraction in the compensation layer.

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20-03-2014 дата публикации

SYSTEMS AND METHODS FOR NETWORKED WEARABLE MEDICAL SENSORS

Номер: US20140079051A1
Автор: Lakkis Ismail, Law Hock
Принадлежит: ADEPTENCE, LLC

A medical sensor system comprises a gateway comprising a wideband receiver and a narrow band transmitter, the each gateway configured to receive a wideband positioning frame using the wideband receiver from one or more wearable sensors and to transmit acknowledgement frames using the narrow band transmitter that include timing and control data for use by the sensors to establish timing for transmission of the positioning frame; and at least one wearable sensor comprising a wideband transmitter and a narrow band receiver, the sensor configured to transmit a sensor data frame to the gateway using the wideband transmitter and to receive an acknowledgement frame from the gateway using the narrow band receiver, extract timing and control information from the frame, and adjust the timing and synchronization of the wideband transmitter using the timing and control information. 1a gateway comprising a wideband receiver and a narrow band transmitter, the each gateway configured to receive a wideband positioning frame using the wideband receiver from one or more wearable sensors and to transmit acknowledgement frames using the narrow band transmitter that include timing and control data for use by the sensors to establish timing for transmission of the positioning frame; andat least one wearable sensor comprising a wideband transmitter and a narrow band receiver, the sensor configured to transmit a sensor data frame to the gateway using the wideband transmitter and to receive an acknowledgement frame from the gateway using the narrow band receiver, extract timing and control information from the frame, and adjust the timing and synchronization of the wideband transmitter using the timing and control information.. A medical sensor system comprising: 1. Technical FieldThe embodiments described herein are related to wireless communication and in particular to systems and methods for medical sensors that can sense a plurality of vital signs and that can provide imaging within the ...

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20-03-2014 дата публикации

Method and device for measuring a mean value of visco-elasticity of a region of interest

Номер: US20140081138A1
Принадлежит: SuperSonic Imagine SA

The invention relates to a method for measuring a mean visco-elasticity value for a soft material. Said method using a single probe carrying at least one transducer comprises the steps of: a) inducing, in a constraint zone, at least one burst of mechanical vibrations in order to generate internal shear waves in the tissue propagating from said constraint zone into the tissue, b1) measuring, with said transducer, the transient tissue displacements in at least one first measurement zone in the tissue, said first measurement zone being located away from said constraint zone, c) estimating a mean visco-elasticity of the region of the tissue situated between the constraint zone and the first measurement zone from said measured transient tissue displacements of the tissue in the first measurement zone.

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27-03-2014 дата публикации

FUNCTIONAL-IMAGING-BASED ABLATION MONITORING

Номер: US20140088418A1
Принадлежит: KONINKLIJKE PHILIPS N.V.

Functional imaging for localization in biological tissue entails measuring a response in the tissue () to electromagnetic radiation. A catheter () for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone () from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption () of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S S) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data. In either case, the members of the dataset pair are combined () by subtraction or division to effect the piece-wise cancellation/enhancement for display () of the resulting signal in real time. 1. An apparatus configured for using functional imaging for localization of biological tissue , said apparatus comprising:a processor for measuring responses in the biological tissue to electromagnetic radiation and distinguishing borders within the biological tissue of one or more of (i) a hemorrhage zone, disposed between (i)(a) healthy tissue and (i)(b) ablated tissue, from said healthy and ablated tissue, and (ii) a contrast agent from bordering native tissue, based upon the responses, wherein distinguishing the borders comprises combining, via the processor, datasets acquired, via a transducer, by electromagnetic irradiation, via an emitter, at different frequencies or frequency bands, wherein the datasets serve as measures of absorption by said biological tissue of the electromagnetic radiation, and wherein the different frequencies or frequency bands are (iii) selected for (iii)(a) differential absorption of radiation in, correspondingly, ...

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27-03-2014 дата публикации

MOTION ROBUST VITAL SIGNAL MONITORING

Номер: US20140088433A1
Автор: Shan Caifeng
Принадлежит: KONINKLIJKE PHILIPS N. V.

The present invention relates to a device and a method for extracting physiological information from remotely detected electromagnetic radiation emitted or reflected by a subject. A data stream derivable from electromagnetic radiation emitted or reflected by a subject is received. The data stream comprises a sequence of signal samples indicative of desired subject motion and of disturbing motion. The signal samples represent at least one region of interest exhibiting an at least partially periodic indicative motion pattern attributable to at least one physiological parameter, and a non-indicative motion region. The sequence of signal samples is processed, comprising deriving a sequence of derivative motion compensated samples at least partially compensated for undesired overall motion; detecting an evaluation parameter representative of motion compensation accuracy; and deriving at least one characteristic signal at least partially indicative of the at least partially periodic indicative motion pattern from the sequence of motion compensated samples, wherein deriving the characteristic signal is performed depending on the detected evaluation parameter. 1. A device for extracting physiological information from remotely detected electromagnetic radiation emitted or reflected by a subject , comprising:an interface for receiving a data stream derivable from electromagnetic radiation emitted or reflected by a subject; and a stabilizer configured for deriving a sequence of derivative motion compensated samples;', 'a motion compensation assessment module configured for detecting an evaluation parameter representative of motion compensation accuracy;', 'an extractor configured for selectively deriving at least one characteristic signal at least partially indicative of an at least partially periodic indicative motion pattern; and', 'an analyzer configured for determining temporal variations in the characteristic signal, the temporal variations being representative of at ...

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27-03-2014 дата публикации

APPARATUSES FOR TREATING AND/OR DIAGNOSING MOTOR-RELATED NEUROLOGICAL CONDITIONS

Номер: US20140088439A1
Принадлежит: Photopharmics, Inc.

Light therapy apparatuses are configured to expose a subject to light that is tailored to address and/or diagnose at least one motor-related neurological condition. Blue-green light and green light are useful for treating motor-related neurological conditions or their symptoms. Deep red light and near infrared radiation may facilitate the repair of retinal cells and/or neurons that may be responsible for motor-related neurological conditions. Amber, orange and red light enable the early diagnosis of motor-related neurological conditions. 1. A system for use with a subject suffering from a motor-related neurological condition , comprising:at least one light source for emitting an above-ambient intensity of at least one first bandwidth of visible light including an intensity peak at a wavelength that treats a motor-related neurological condition, a majority of light emitted by the at least one light source comprising wavelengths that treat the motor-related neurological condition, the wavelengths that treat the motor-related neurological condition including a range of 520 nm to 570 nm.2. The system of claim 1 , wherein the wavelengths that treat the motor-related neurological condition are from 490 nm to 570 nm.3. The system of claim 1 , wherein the light source is not configured to emit light outside of the wavelengths that treat the motor-related neurological condition.4. The system of claim 1 , wherein the at least one light source includes:at least one light source that generates the intensity peak of the at least one first bandwidth of visible light; andat least one filter for limiting ocular exposure of a subject to extraneous wavelengths of visible light generated by the light source that are outside of the first bandwidth of visible light.5. The system of claim 4 , wherein the at least one filter limits passage of the extraneous wavelengths of visible light therethrough to ambient or below-ambient amounts.6. The system of claim 4 , wherein the at least one ...

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03-04-2014 дата публикации

Multispectral imaging for quantitative contrast of functional and structural features of layers inside optically dense media such as tissue

Номер: US20140092288A1
Принадлежит: Individual

A method for evaluation of target media parameters using visible through near infrared light is disclosed. The apparatus comprises a light source, illuminator/collector, optional illumination wavelength selector, optional light gating processor, imager, detected wavelength selector, controller, analyzer and display unit. The apparatus illuminates an in situ target. The sample absorbs some light while a large fraction of the light is diffusely scattered within the sample and some light exits the sample and may be detected in an imaging fashion using wavelength selection and an optical imaging system. The method extends the dynamic range of the optical imager by extracting additional information from the detected light that is used to provide reconstructed contrast of smaller concentrations of chromophore. Using a reiterative calibration method, acquired spectra and images are analyzed and displayed in near real time in such a manner as to characterize functional and structural information of the target tissue

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03-04-2014 дата публикации

Apparatus, systems and methods for monitoring and evaluating cardiopulmonary functioning

Номер: US20140094663A1
Принадлежит: Valencell, Inc.

Wearable apparatus for monitoring various physiological and environmental factors are provided. Real-time, noninvasive health and environmental monitors include a plurality of compact sensors integrated within small, low-profile devices, such as earpiece modules. Physiological and environmental data is collected and wirelessly transmitted into a wireless network, where the data is stored and/or processed.

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10-04-2014 дата публикации

Defibrillator including light sensor

Номер: US20140100433A1
Принадлежит: Zoll Medical Corp

Systems and methods related to the field of cardiac resuscitation, and in particular to devices for assisting rescuers in performing cardio-pulmonary resuscitation (CPR) are described herein.

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10-04-2014 дата публикации

SYSTEMS AND PROCESSES FOR CORTICAL INTEGRITY ASSESSMENT

Номер: US20140100473A1
Автор: OBRIEN Todd
Принадлежит:

An enhanced system and process for assessment of cortical integrity is disclosed. The system permit detection of cortical disruption through identification of at least one of frequency shifts and significantly reduced vibration transmission in injured versus non-injured bones. Radiography and concomitant exposure to the same is reduced along with risks and costs of the same. 1. A system for cortical integrity assessment , which comprises , in combination:at least a means for analyzing vibrational stimuli transmitted through bone; and,further comprising a means for detection of cortical disruption of significantly reduced vibration transmission in injured versus non-injured bones.2. The system of claim 1 , further comprising at least a software application including data registration and processing accumulated by applying an input and measuring output claim 1 , to generate resultory plotted results.3. The system of claim 2 , which comprises claim 2 , in combination claim 2 , at least applying vibration to a subject bone claim 2 , and then measuring the vibration as modulated by the bone.4. The system of claim 1 , further comprising analyzing a resultory output signal.5. The system of claim 4 , whereby fractures are identified by at least one method selected from the group of frequency response assessment and reduction in amplitude measurement.6. The system of claim 5 , the frequency response being measured by application of a wide frequency spectrum and calculation of impulse response by deconvolution of the input signal and an output signal of the system.7. The system of claim 4 , further comprising at least a conventional smartphone effective for running a subject application.8. The system of claim 7 , further comprising at least two conventional smartphones claim 7 , each effective for running a subject application.9. The system of claim 8 , wherein the application further comprises output and display means for showing results of processed data.10. A process for ...

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