Applicator

Disclosed is an applicator or handpiece configured to apply treatment energy to a segment of skin located in a tissue or skin treatment plane. The treatment energy could be RF energy, applied by a pair of bipolar RF electrodes or optical energy. The applicator includes an optical system configured to form a rectangular spot and homogenize the optical energy distribution.

Cryogenic Cylinder

A cryogenic cylinder including authenticating features and an apparatus recognizing the features and facilitation the cylinder use. The authenticating features prevent use of an unauthorized cryogenic cylinders. The cylinder also includes a number of mechanical features preventing repeat filling of the cylinder by cryogenic fluid or reuse of the cylinder once empty. 1. A cryogenic liquid storing cylinder comprising:a liquid containing body configured to contain a liquid under pressure;a fitting configured to include a single use fitting valve facilitating inlet of the liquid into the liquid containing body of the cylinder;wherein the single use fitting valve is also configured to facilitate dispensing the liquid from the liquid containing body of a liquid storing cylinder; andwherein the single use fitting valve is configured to be destroyed upon depletion of the liquid in the cylinder.2. The liquid storing cylinder according to wherein the single use fitting valve falls inside the container upon depletion of the liquid in the container.3. The liquid storing cylinder according to wherein the cylinder further includes a pressure relief valve; and wherein the pressure relief valve operates on a gaseous aggregate state of the liquid.4. The liquid storing cylinder according to wherein the cylinder includes at least one cylinder authenticating feature associated with the cylinder.5. The liquid storing cylinder according to further comprising an electronic module located at inlet of the liquid into the container.6. The liquid storing cylinder according to further comprising an electronic module located in the fitting valve facilitating inlet of the liquid into the liquid containing body of the cylinder.7. The liquid storing cylinder according to wherein the fitting valve includes at least one of a group of authentication features consisting of a mechanical feature claim 1 , electronic circuit claim 1 , readable information and a combination of the above.8. An apparatus ...

HYPERSPECTRAL TISSUE OXYGENATION MEASUREMENT SYSTEM

The invention is directed to a hyperspectral/multispectral system referred to as the OxyVu-1 system. The hyperspectral imaging technology performs spectral analysis at each point in a two-dimensional scanned a producing an image displaying information derived from the analysis. For the OxyVu-1 system, the spectral analytical methods determined in superficial tissues approximate values of oxygen saturation (HT-Sat), oxyhemoglobin levels (HT-oxy), and deoxyhemoglobin levels (HT-deoxy). The OxyVu-1 system displays the tissue oxygenation in a two-dimensional, color-coded image. 1. A non-invasive , tissue oxygenation measurement system comprising:a hyperspectral/multispectral imaging camera that reports an approximate value of: oxygen saturation, oxyhemoglobin level, and deoxyhemoglobin level in superficial tissue;a display for projecting two-dimensional color-coded images of tissue oxygenation ofa scanned surface of one or more regions of the superficial tissue.2. The system of claim 1 , wherein the oxygenation measurements comprise one or more of: a value for oxyhemoglobin claim 1 , a value for deoxyhemoglobin claim 1 , and a value for percent oxygen saturation.3. The system of claim 1 , wherein tissue oxygenation information can be viewed pixel-by-pixel claim 1 , as a region of interest claim 1 , or for a viewing area.4. The system of claim 1 , further comprising one or more of a system console claim 1 , a cart claim 1 , system electronics claim 1 , CPU claim 1 , monitor claim 1 , keyboard claim 1 , pointing device and printer.5. The system of comprising a hyperspectral instrument head with a support arm claim 1 , wherein the hyperspectral instrument head contains a broadband illuminator claim 1 , the camera claim 1 , and a spectral filter for collecting a three-dimensional matrix of spectral measurements in the form of a hyperspectral imaging cube.6. The system of claim 1 , wherein the two-dimensional images have a 0.1 mm spatial resolution within a 10 cm by 13 cm ...

Reduction of RF electrode edge effect

A skin surface is treated with RF energy (e.g., unipolar, monopolar, bipolar or multipolar RF delivery). A first semiconductive cap disposed on a first distal end of a first electrode and, optionally, a second semiconductive cap disposed on a second distal end of a second electrode are applied to the skin surface. RF energy is delivered from the first electrode and the second electrode through the first semiconductive cap and the second semiconductive cap, respectively, through the skin surface. The first semiconductive cap and/or the second semiconductive cap have an electrical conductivity matched or substantially matched to the skin's electrical conductivity (e.g., about 0.1 to about 2 times that of the skin).

Skin Treatment Method And Apparatus

The application discloses a number of methods and apparatuses suitable for selective skin treatment have been described. In one example, a pair of RF electrodes is applied to skin. The RF electrodes receive RF energy from an RF energy generator. The RF electrodes are also configured to apply positive pressure to a segment of skin located between the pair of RF electrodes to partially or completely occlude the blood flow in one or more vessels in the segment of skin located between the pair of RF electrodes. Occlusion of the blood flow reduces heat dissipation by the skin segment located between the pair of RF electrodes and supports further increase of temperature of both the skin segment and vessels located between the pair of electrodes.

OxyVu-1 hyperspectral tissue oxygenation (HTO) measurement system

The invention is directed to a hyperspectral/multispectral system referred to as the OxyVu-1 system. The hyperspectral imaging technology performs spectral analysis at each point in a two-dimensional scanned area producing an image displaying information derived from the analysis. For the OxyVu-1 system, the spectral analytical methods determined in superficial tissues approximate values of oxygen saturation (HT-Sat), oxyhemoglobin levels (HT-Oxy), and deoxyhemoglobin levels (HT-Deoxy). The OxyVu-1 system displays the tissue oxygenation in a two-dimensional, color-coded image. The system contains a system console, a cart, system electronics, CPU, monitor, keyboard, pointing device and printer. The hyperspectral instrument head with support arm contains broadband illuminator, camera and spectral filter for collecting hyperspectral imaging cube. The single use OxyVu Check Pads and Targets are used to perform an instrument check prior to patient measurements. The OxyVu Target is placed within the intended field of view and is used as a fiduciary mark for image registration and for focusing.

Driving Microneedle Arrays into Skin and Delivering RF Energy

A skin treatment includes applying vacuum to draw skin into contact with a plate defining a plurality of holes, inserting a plurality of needles through the plurality of holes into the skin, and delivering RF energy via the plurality of needles to treat the skin. 1. An apparatus for treating skin , comprising:a housing defining a volume, the housing including a ceiling and a wall extending from the ceiling, the wall having an edge for contacting the skin, the edge of the wall defining an aperture in the housing;a plate disposed in the housing, the plate intersecting the wall and dividing the volume of the housing into two sub-volumes so that the wall extends above and below the plate, wherein (i) a first sub-volume is defined by the ceiling, the wall and a top surface of the plate, (ii) a second sub-volume is defined by a bottom surface of the plate, the wall and the aperture defined by the edge of the wall, and (iii) the plate defines a plurality of holes so that the first sub-volume and the second sub-volume are in fluid communication;a vacuum port defined in the ceiling or the wall of the housing, vacuum applied to draw the skin though the aperture and into contact with the bottom surface of the plate;a needle array comprising a plurality of needles extending from a base, each needle aligned with a respective hole defined in the plate;an actuator mechanism in communication with the needle array, the actuator mechanism configured to cause the plurality of needles to pass through their respective holes into the skin; anda source of RF energy in electrical communication with the plurality of needles.2. The apparatus of wherein each needle includes (i) a shaft covered with an insulating material and (ii) an exposed tip to deliver the RF energy.3. The apparatus of wherein the actuator mechanism comprises a solenoid.4. The apparatus of wherein the actuator mechanism is adapted to drive the plurality of needles into the skin at a velocity of at least 100 mm/s.5. The ...

Reduction of Pain through Lower Fluence Rates and Longer treatment Times

A method of treating a subcutaneous fat region is provided. The method includes generating electromagnetic radiation having a wavelength of about 1,200 nm to about 1,230 nm and delivering an average power density of less than or equal to about 2.3 W/cmof the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds. The method also includes cooling an epidermal region and at least a portion of a dermal region overlying the subcutaneous fat region for at least a portion of the at least 300 seconds. The method further includes causing necrosis of at least one fat cell in the subcutaneous fat region. 1. A method of treating a subcutaneous fat region , comprising:generating electromagnetic radiation having a wavelength of about 1,200 nm to about 1,230 nm;{'sup': '2', 'delivering an average power density of less than or equal to about 2.3 W/cmof the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds;'}cooling an epidermal region and at least a portion of a dermal region overlying the subcutaneous fat region for at least a portion of the at least 300 seconds; andcausing necrosis of at least one fat cell in the subcutaneous fat region.2. The method of further comprising delivering the electromagnetic radiation to the subcutaneous fat region for about 300 seconds to about 400 seconds.3. The method of wherein the electromagnetic radiation comprises a plurality of pulses of electromagnetic radiation.4. The method of wherein the average power density is about 0.5 W/cmto about 2.5 W/cm.5. The method of wherein the peak power density exceeds about 2.5 W/cm.6. The method of further comprising delivering the electromagnetic radiation simultaneously to a surface of skin overlying the subcutaneous fat region claim 1 , the surface of skin having an area of at least 10 cm.7. The method of further comprising delivering the electromagnetic radiation in the absence of precooling of the epidermal region and the portion of the dermal ...

HYPERSPECTRAL IMAGING OF ANGIOGENESIS

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease and cancer, that incorporate hyperspectral or multispectral imaging. 1. A multispectral or hyperspectral medical imaging system comprising:a plurality of LED lights, each respective LED light in the plurality of LED lights configured to emit radiation at a particular spectral band in a plurality of spectral bands used by a diagnostic protocol module;a first stage optic configured to receive radiation projected, from one or more respective LED lights in the plurality of LED lights, off of an in vivo tissue located at a region of interest on a subject;one or more polarizers in optical communication with the first stage optic;an imaging sensor for recording an image of the radiation projected off of the in vivo tissue;a diagnostic protocol module adapted to detect a particular characteristic of the in-vivo tissue; and switch one or more respective LED light in the plurality of LED lights off and on based on the diagnostic protocol module,', 'instruct the imaging sensor to record a plurality of images of the region of interest based on the diagnostic protocol module, each respective image in the plurality of images corresponding to radiation emitted at a particular spectral band by one or more respective LED light in the plurality of LED lights,', 'obtain a multispectrally or hyperspectrally resolved image based on the plurality of images, and', (i) a color hue plane that represents a first characteristic in the group consisting of (a) the oxyhemoglobin concentration, (b) the deoxyhemoglobin concentration and (c) a mathematical combination of the oxyhemoglobin concentration and the deoxyhemoglobin concentration,', '(ii) a color saturation plane that ...

DEVICES FOR THE TREATMENT OF BIOLOGICAL TISSUE

An apparatus for treating a subcutaneous fat region is provided. The apparatus includes a housing that has a skin contacting portion defining a chamber. The apparatus also includes a first spaced region in the housing through which a coolant passes and a second spaced region in the housing that is at least partially evacuated of air. The apparatus further includes a source of electromagnetic radiation, a source of vacuum in fluid communication with the chamber, and a source for the coolant. 1. An apparatus for treating a subcutaneous fat region , comprising:a housing including a skin contacting portion defining a chamber, wherein the chamber is defined by a bottom surface of a first transparent optic recessed in the chamber and a rim extending from the perimeter of the first transparent optic toward the skin contacting portion;a second transparent optic including a bottom surface spaced from a top surface of the first transparent optic, the second transparent optic disposed in the housing, the first transparent optic and the second transparent optic defining a first spaced region through which a coolant passes;a third transparent optic including a bottom surface spaced from a top surface of the second transparent optic, the third transparent optic disposed in the housing, the second transparent optic and the third transparent optic defining a second spaced region at least partially evacuated of air;a source of electromagnetic radiation disposed in the housing relative to a top surface of the third transparent optic;a source of vacuum in fluid communication with the chamber, the source of vacuum capable of removing air from inside the chamber so that a surface of skin overlying the subcutaneous fat region is drawn into contact with the bottom surface of the first transparent optic.a source for the coolant, the source flowing the coolant through the first spaced region so that thermal energy is removed through the first transparent optic from an epidermal region and ...

Reduction of RF Electrode Edge Effect

A skin surface is treated with bipolar RF energy. A first semiconductive cap disposed on a first distal end of a first electrode and a second semiconductive cap disposed on a second distal end of a second electrode are applied to the skin surface. RF energy is delivered from the first electrode and the second electrode through the first semiconductive cap and the second semiconductive cap, respectively, through the skin surface. A thickness of each semiconductive cap between a blunt skin contacting surface and a curved surface affixed to a respective electrode is thicker at an inner portion and thinner at a center portion to homogenize the electrical field at the skin surface. 1. An applicator for bipolar RF energy delivered through a skin surface , comprising:a base;a first electrode connected to the base and extending from the base toward a first location of the skin surface;a second electrode connected to the base and extending from the base toward a second location of the skin surface, the second electrode being laterally offset from the first electrode along the skin surface, the first electrode and the second electrode having opposite phases;a first semiconductive cap disposed on a first distal end of the first electrode, the first semiconductive cap having a first blunt surface adapted to contact the first location of the skin surface and a curved surface affixed to the first electrode; anda second semiconductive cap disposed on a second distal end of the second electrode, the second semiconductive cap having a second blunt surface adapted to contact the second location of the skin surface and a second curved surface affixed to the second electrode;wherein the RF energy is delivered from the first electrode and the second electrode through the first semiconductive cap and the second semiconductive cap, respectively, through the skin surface;wherein a thickness of each semiconductive cap between the blunt surface and the curved surface is thicker at an inner ...

Reduction of RF Electrode Edge Effect

A skin surface is treated with RF energy (e.g., unipolar, monopolar, bipolar or multipolar RF delivery). A first semiconductive cap disposed on a first distal end of a first electrode and, optionally, a second semiconductive cap disposed on a second distal end of a second electrode are applied to the skin surface. RF energy is delivered from the first electrode and the second electrode through the first semiconductive cap and the second semiconductive cap, respectively, through the skin surface. The first semiconductive cap and/or the second semiconductive cap have an electrical conductivity matched or substantially matched to the skin's electrical conductivity (e.g., about 0.1 to about 2 times that of the skin).

HYPERSPECTRAL IMAGING IN DIABETES AND PERIPHERAL VASCULAR DISEASE

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging. 1. A multispectral or hyperspectral medical imaging system comprising:a plurality of LED lights, each respective LED light in the plurality of LED lights configured to emit radiation at a particular spectral band in a plurality of spectral bands used by a diagnostic protocol module;a first stage optic configured to receive radiation projected, from one or more respective LED lights in the plurality of LED lights, off of an in vivo tissue located at a region of interest on a subject;an imaging sensor for recording an image of the radiation projected off of the in vivo tissue;a diagnostic protocol module adapted to detect a particular characteristic of the in-vivo tissue; switch one or more respective LED light in the plurality of LED lights off and on based on the diagnostic protocol module,', 'instruct the imaging sensor to record a plurality of images of the region of interest based on the diagnostic protocol module, each respective image in the plurality of images corresponding to radiation emitted at a particular spectral band by one or more respective LED light in the plurality of LED lights,', 'co-register corresponding pixels in each image in the plurality of images;', 'derive a coefficient for oxyhemoglobin and a coefficient for deoxyhemoglobin from each set of co-registered pixels in the plurality of images;', 'generate, based on the plurality of images, a two-dimensional index characterizing the particular characteristic of the in vivo tissue, wherein the two-dimensional index includes a first scale to represent a concentration of oxyhemoglobin in the in vivo tissue, and a second scale to ...

Systems and Methods for Combining Hyperspectral Images with Color Images

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease and cancer, that incorporate hyperspectral or multispectral imaging. 129-. (canceled)30. A method of obtaining information about a region of interest of a subject , the method comprising:a) resolving light obtained from the region of interest of the subject into a plurality of component spectral bands;b) constructing a pseudo color spectral image based on the plurality of component spectral bands; andc) combining the pseudo color spectral image with a color photo image of the area of the region of interest to form a composite image.31. The method of claim 30 , wherein a wavelength range of each respective component spectral band in the plurality of component spectral bands is adjacent to the wavelength range of another component spectral band in the plurality of component spectral bands.32. The method of claim 30 , wherein each respective component spectral band in the plurality of component spectral bands has a bandwidth of less than 50 nm.33. The method of claim 30 , wherein each respective component spectral band in the plurality of component spectral bands has a bandwidth that is between 10 nm and 40 nm.34. The method of claim 30 , wherein each respective component spectral band in the plurality of component spectral bands has a bandwidth that is between 10 nm and 15 nm.35. The method of claim 30 , wherein each respective component spectral band in the plurality of component spectral bands has a bandwidth that is between 5 nm and 12 nm.36. The method of claim 30 , the method further comprising displaying the composite image on a computer screen.37. The method of claim 30 , wherein the region of interest of the subject is a portion of the skin of the ...

Systems and Methods for Projecting Hyperspectral Images

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease and cancer, that incorporate hyperspectral or multispectral imaging. 129-. (canceled)30. A method of displaying information about a region of interest of a subject , the method comprising:a) resolving light obtained from the region of interest into a plurality of component spectral bands;b) constructing a hyperspectral image from the plurality of component spectral bands; andc) projecting the hyperspectral image onto the subject.31. The method of claim 30 , the method further comprising applying a fiducial label to the subject and wherein the projecting comprises co-registering the hyperspectral image with the fiducial label.32. The method of claim 30 , wherein the projecting comprises using information from a calibration pad that includes a diffusely reflective surface that quantifies an intensity of illumination at each wavelength represented by the plurality of component spectral bands to co-register the hyperspectral image with the subject.33. The method of claim 30 , wherein the hyperspectral image is a pseudo color hyperspectral image.34. The method of claim 33 , wherein the pseudo color hyperspectral image allows discrimination between tissue types.35. The method of claim 34 , wherein the pseudo color hyperspectral image allows discrimination of a superficial blood vessel.36. The method of claim 30 , wherein a wavelength range of each respective component spectral band in the plurality of component spectral bands is adjacent to the wavelength range of another component spectral band in the plurality of component spectral bands.37. The method of claim 30 , wherein each respective component spectral band in the plurality of component spectral bands ...

HYPERSPECTRAL IMAGING IN DIABETES AND PERIPHERAL VASCULAR DISEASE

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging. 124-. (canceled)25. A method for displaying information obtained from medical multispectral or hyperspectral imaging comprising: obtaining a plurality of images of an in vivo tissue located at a region of interest on a subject, each respective image in the plurality of images resolved at a particular spectral band of radiation in a plurality of spectral bands, wherein corresponding pixels in each image in the plurality of images are co-registered into sets of co-registered pixels;', 'deriving a coefficient for oxyhemoglobin (x) and a coefficient for deoxyhemoglobin (y) from each set of co-registered pixels in the plurality of images;', 'generating, based on the plurality of images, an index of the in vivo tissue, wherein the index includes a representation of a concentration of oxyhemoglobin in the in vivo tissue, and a representation of a concentration of deoxyhemoglobin in the in vivo tissue;', 'displaying the coefficient for oxyhemoglobin (x) and the coefficient for deoxyhemoglobin (y) from at least one set of co-registered pixels in the plurality of images independently with the index, thereby conveying spatial information about oxyhemoglobin concentration and deoxyhemoglobin concentration in the tissue., 'at a computing system comprising one or more processors and memory storing one or more programs for execution by the one or more processors26. The method of claim 25 , wherein the computing system comprises a portable multispectral or hyperspectral medical imaging system and a second computing system located at a remote location.27. The method of claim 26 , wherein the method further ...

Hyperspectral technology for assessing and treating diabetic foot and tissue disease

This invention relates generally to an index map comprising both pressure and perfusion information from a diabetic patient foot for the purpose of treatment. The index map may also be a map of perfusion and/or metabolism of the tissue (reflecting oxygen delivery and oxygen extraction, obtained by thermal imaging, hyperspectral imaging, or duplex ultrasound, MRA, CT or laser Doppler imaging. This information aids treatment in prevention of diabetic foot ulceration and amputation and in treatment of tissue compromise to prevent tissue loss in other body regions.

Applicator

Disclosed is an applicator or handpiece configured to apply treatment energy to a segment of skin located in a tissue or skin treatment plane. The treatment energy could be RF energy, applied by a pair of bipolar RF electrodes or optical energy. The applicator includes an optical system configured to form a rectangular spot and homogenize the optical energy distribution. 1. An applicator , comprising:a housing having an axis of symmetry and a proximal and a distal end;a support structure extending from the distal end and terminated by a frame and wherein the support structure is angled with respect to axis of symmetry of the housing;a pair of bipolar RF electrodes mounted on the support structure, the electrodes configured to apply RF energy to tissue located in tissue treatment plane;an optical system configured to receive a beam of optical energy from a source of optical energy and convey it to the tissue located in the tissue treatment plane and wherein the tissue treatment plane is located between the pair of the bipolar RF electrodes.2. The applicator according to wherein the optical system includes a light pipe homogenizing rod with tapered output facet configured to shape cross section of image of the tapered output facet of the light pipe homogenizing rod in the tissue treatment plane.3. The applicator according to wherein the light pipe homogenizing rod is one of a group of light guides consisting of a tapered light homogenizing rod claim 2 , a tapered optical trapezoidal prism claim 2 , a tapered multi-facet optical homogenizing rod or a tapered hollow light guide with a reflective coating deposited on inner surfaces of the light guide.4. The applicator according to wherein the optical system includes a pair of lenses configured to receive a homogenized beam of optical energy from light pipe homogenizing rod and image output facet of light pipe homogenizing rod to a treated skin or tissue plane located between the pair of bipolar RF electrodes and wherein ...

Cooling System For Tissue Treatment System With Both Tissue And Light Source Cooling

A tissue treatment system includes an applicator connected with a base unit. The applicator includes a light source to generate light energy. A light guide directs the light energy to biological tissue and is configured to contact biological tissue. A thermoelectric cooler has a cold side and a hot side, with the cold side being associated with the light guide. A hot side plate is mounted to the hot side of the thermoelectric cooler. A first fluid passage is between the reservoir and the hot side plate to deliver cooling fluid over the hot side plate to chill the cold side of the thermoelectric cooler and cool the light guide and biological tissue. A second fluid passage is associated with the light source to direct cooling fluid to the light source prior to being returned to the reservoir. The first and second fluid passages define a single cooling fluid circulation loop. 1. A tissue treatment system comprising:a base unit having a power source and a reservoir for containing a cooling fluid, a tissue cooling element constructed and arranged to engage biological tissue for treatment, the tissue cooling element including channel structure there-through,', 'a light source powered by the power source and constructed and arranged to generate light energy directed to the tissue cooling element and thus to the biological tissue,, 'an applicator connected with the base unit via a cable, the applicator comprisinga first fluid passage between the reservoir and the channel structure of the tissue cooling element to deliver cooling fluid through the tissue cooling element, anda second fluid passage between the channel structure and the reservoir to return the cooling fluid to the reservoir, the second fluid passage being associated with the light source to direct cooling fluid to the light source prior to being returned to the reservoir,wherein the first and second fluid passages define a single cooling fluid circulation loop to cool both the tissue cooling element and the ...

Smoke Evacuation System

Smoke evacuation system for removal of aerosolized chemical compounds and biological fine particles produced during laser treatment of tissue. The rapid smoke evacuation is achieved by coupling a low capacity vacuum pump to a vacuum valve and a vacuum reservoir to create very high flow rate for very short durations. The opening time of the valve could at least partially overlap the laser pulse duration.

Reduction Of Pain Through Lower Fluence Rates And Longer Treatment

A method of treating a subcutaneous fat region is provided. The method includes generating electromagnetic radiation having a wavelength of about 1,200 nm to about 1,230 nm and delivering an average power density of less than or equal to about 2.3 W/cm 2 of the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds. The method also includes cooling an epidermal region and at least a portion of a dermal region overlying the subcutaneous fat region for at least a portion of the at least 300 seconds. The method further includes causing necrosis of at least one fat cell in the subcutaneous fat region.

OXYVU-1 HYPERSPECTRAL TISSUE OXYGENATION (HTO) MEASUREMENT SYSTEM

The invention is directed to a hyperspectral/multispectral system referred to as the OxyVu-1 system. The hyperspectral imaging technology performs spectral analysis at each point in a two-dimensional scanned area producing an image displaying information derived from the analysis. For the OxyVu-1 system, the spectral analytical methods determined in superficial tissues approximate values of oxygen saturation (HT-Sat), oxyhemoglobin levels (HT-Oxy), and deoxyhemoglobin levels (HT-Deoxy). The OxyVu-1 system displays the tissue oxygenation in a two-dimensional, color-coded image. 140-. (canceled)41. A non-transitory computer readable storage medium storing one or more programs , the one or more programs comprising instructions which , when executed by an imaging system configured to acquire a plurality of images of a tissue of a subject , cause the imaging system to:resolve a plurality of absorption signals from the plurality of images,account for a contribution provided by melanin and losses caused by diffuse scattering in each respective absorption signal in the plurality of absorption signals, wherein the respective contribution provided by melanin and the respective losses provided by diffuse scattering to each respective absorption signal in the plurality of absorption signals are collectively modeled, thereby forming a plurality of corrected absorption signals,determine a plurality of tissue oxygenation measurements for the tissue based on the plurality of corrected absorption signals, andform a two-dimensional image of tissue oxygenation of the tissue from the plurality of tissue oxygenation measurements.42. The non-transitory computer readable storage medium of claim 41 , wherein the plurality of tissue oxygenation measurements comprise: a value for oxyhemoglobin and a value for deoxyhemoglobin.43. The non-transitory computer readable storage medium of claim 41 , wherein the two-dimensional image of tissue oxygenation comprises a plurality of pixels and for ...

A Transparent Electrode

An applicator for cosmetic treatment of skin including one or more sources of light energy and one or more transparent electrode assemblies positioned between the source of light energy and skin to be treated. The transparent electrode assembly supports transmission of light energy from the light source to one or more segments of skin located directly under and in contact with the electrode assembly. The electrode assembly can also include transparent RF electrodes that measure skin impedance (temperature). 1. Applicator for cosmetic treatment of skin , comprising:at least one source of light energy;at least one transparent electrode assemblies positioned between the source of light energy and skin to be treated; andwherein the transparent electrode assembly supports transmission of light energy from the light source to at least one segment of skin located directly under and in contact with the electrode assembly.2. The applicator of claim 1 , wherein a transparent electrode assembly supports concurrent application of combined RF energy and light energy to uniformly heat segments of skin for cosmetic treatment.3. The applicator of claim 1 , wherein a transparent electrode assembly comprises:at least one transparent carrier made of a non-electrically conductive transparent material that supports transmission of light energy therethrough;at least one transparent RF energy electrode elements deposited on at least a portion of a non-electrically conductive first surface on a skin-contacting side of the carrier; andat least one RF contacts to provide electrical contact between the transparent RF energy electrode elements and a source of RF energy.4. The applicator of claim 3 , wherein the transparent carrier is made of at least one non-electrically conductive transparent material selected from a group of materials including borosilicate glass (e.g. claim 3 , Corning® Pyrex® claim 3 , Eagle XG®) claim 3 , soda lime glass claim 3 , sapphire and other similar transparent ...

Devices For The Treatment of Biological Tissue

An apparatus for treating a subcutaneous fat region is provided. The apparatus includes a housing that has a skin contacting portion defining a chamber. The apparatus also includes a first spaced region in the housing through which a coolant passes and a second spaced region in the housing that is at least partially evacuated of air. The apparatus further includes a source of electromagnetic radiation, a source of vacuum in fluid communication with the chamber, and a source for the coolant. 136-. (canceled)37. A method for treating a subcutaneous fat region , comprising:delivering a uniform energy distribution of electromagnetic radiation to a surface of skin overlying the subcutaneous fat region using a skin contacting applicator, wherein the electromagnetic radiation is provided by a plurality of laser diodes spaced in a plurality of rows and columns; andapplying a coolant and removing thermal energy from an epidermal region and at least a portion of a dermal region of skin overlying the subcutaneous fat region without the coolant being directly exposed to the surface of the skin.38. The method according to claim 37 , wherein also drawing the surface of skin overlying the subcutaneous fat region into a portion of the applicator housing in which the laser diodes are integrated by removing air from inside the portion of the housing.39. The method according to claim 38 , wherein delivering the electromagnetic radiation to the subcutaneous fat region when a threshold value of pressure is reached.40. The method according to claim 37 , wherein delivering the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds.41. The method according to claim 37 , wherein providing electromagnetic radiation having a wavelength of 1 claim 37 ,200 nm to 1 claim 37 ,230 nm and a power density of less than or equal to 2.3 W/cm.42. The method according to claim 38 , wherein flattening the surface of skin claim 38 , or compressing the surface of skin claim 38 , ...

OXYVU-1 HYPERSPECTRAL TISSUE OXYGENATION (HTO) MEASUREMENT SYSTEM

The invention is directed to a hyperspectral/multispectral system referred to as the OxyVu-1 system. The hyperspectral imaging technology performs spectral analysis at each point in a two-dimensional scanned area producing an image displaying information derived from the analysis. For the OxyVu-1 system, the spectral analytical methods determined in superficial tissues approximate values of oxygen saturation (HT-Sat), oxyhemoglobin levels (HT-Oxy), and deoxyhemoglobin levels (HT-Deoxy). The OxyVu-1 system displays the tissue oxygenation in a two-dimensional, color-coded image.

Cryogenic Cylinder

A cryogenic cylinder including authenticating features and an apparatus recognizing the features and facilitation the cylinder use. The authenticating features prevent use of an unauthorized cryogenic cylinders. The cylinder also includes a number of mechanical features preventing repeat filling of the cylinder by cryogenic fluid or reuse of the cylinder once empty. 1. An apparatus for aesthetic skin treatment configured to receive at least one cryogenic liquid storing cylinder for storing and dispensing a cryogenic liquid including:At least one cylinder authentication module providing information on at least one of the authenticity of the cryogenic liquid cylinder and cryogenic liquid filling the cylinder; andat least one controller configured to communicate with at least one identification feature of the cryogenic liquid cylinder and content of the cylinder.2. The apparatus according to wherein the at least one controller is further configured to keep record of at least one of amount of cryogenic liquid remaining in the cylinder and amount of cryogenic liquid dispensed from the cylinder.3. The apparatus according to wherein the cylinder authentication module is at least one of a group of modules consisting of a mechanical module claim 1 , electronic module claim 1 , readable information module and a combination of the above.4. The apparatus according to wherein the cylinder authentication module includes a mechanical cylinder authentication module having specially keyed mating pins made in the cryogenic cylinder and in an apparatus receiving the cylinder.5. The apparatus according to wherein the cylinder authentication module includes an electronic cylinder authentication module that is at least one of a group of modules consisting of RFID tags claim 1 , customized integrated circuits claim 1 , physical and chemical analyses of the cryogenic liquid and a combination of the above.6. The apparatus according to wherein the cylinder authentication module is at least ...

Reduction Of Pain Through Lower Fluence Rates And Longer Treatment

An apparatus for treatment of a subcutaneous fat region includes a source of electromagnetic radiation generating electromagnetic radiation having a non-fat selective wavelength. A delivery system is coupled to the source of electromagnetic radiation and is configured to deliver the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds. A controller is configured to adjust an average power density based on a thickness of skin overlying the subcutaneous fat region, and to cause necrosis of at least one fat cell in the subcutaneous fat region. The non-fat selective wavelength is 950 nm to 1090 nm, 1100 nm to 1160 nm, 1,300 nm to 1625 nm, or 1,800 nm to 2,200 nm.

Reduction of RF Electrode Edge Effect

A skin surface is treated with RF energy (e.g., unipolar, monopolar, bipolar or multipolar RF delivery). A first semiconductive cap disposed on a first distal end of a first electrode and, optionally, a second semiconductive cap disposed on a second distal end of a second electrode are applied to the skin surface. RF energy is delivered from the first electrode and the second electrode through the first semiconductive cap and the second semiconductive cap, respectively, through the skin surface. The first semiconductive cap and/or the second semiconductive cap have an electrical conductivity matched or substantially matched to the skin's electrical conductivity (e.g., about 0.1 to about 2 times that of the skin). 123-. (canceled)24. An applicator for RF energy delivered through a skin surface , comprising:a base;a first electrode connected to the applicator base and extending from the applicator base toward a first location of the skin surface; anda first semiconductive cap disposed on a first distal end of the first electrode, the first semiconductive cap being configured to contact the first location of the skin surface,wherein the RF energy is delivered from the first electrode through the first semiconductive cap through the skin surface; andwherein the first semiconductive cap has an electrical conductivity of about 0.03 S/m to about 3.0 S/m and a thermal conductivity of about 5 W/m·° C. to about 500 W/m·° C.25. The applicator according to claim 24 , further comprising:a second electrode connected to the applicator base and extending from the applicator base toward a second location of the skin surface, the second electrode being laterally offset from the first electrode along the skin surface; anda second semiconductive cap disposed on a second distal end of the second electrode, the second semiconductive cap being configured to, in use contact the second location of the skin surface;wherein the RF energy is delivered from the first electrode and the second ...

Monopolar rf subcutaneous fat treatment systems and methods

A subcutaneous fat treatment system and method. An electrode is for application to a patient's epidermis above subcutaneous fat to be treated. There may optionally be a cooling subsystem for cooling the electrode. A sensor such as a microwave radiometer measures the temperature of the subcutaneous fat to be treated. In addition or in the alternative, a subcutaneous fat thickness measurement may be used. A radio frequency source is for applying radio frequency energy to the electrode. A controller subsystem is responsive to the sensor and/or the subcutaneous fat thickness measurement and controls the radio frequency source to determine the thermal dose applied to the subcutaneous fat being treated and automatically adjust the radio frequency energy supplied to the electrode subjecting the subcutaneous fat to a thermal dose of between 0.1 and 10.0.

Reduction of RF Electrode Edge Effect

A skin surface is treated with RF energy (e.g., unipolar, monopolar, bipolar or multipolar RF delivery). A first semiconductive cap disposed on a first distal end of a first electrode and, optionally, a second semiconductive cap disposed on a second distal end of a second electrode are applied to the skin surface. RF energy is delivered from the first electrode and the second electrode through the first semiconductive cap and the second semiconductive cap, respectively, through the skin surface. The first semiconductive cap and/or the second semiconductive cap have an electrical conductivity matched or substantially matched to the skin's electrical conductivity (e.g., about 0.1 to about 2 times that of the skin).

Smoke Evacuation System

Smoke evacuation system for removal of aerosolized chemical compounds and biological fine particles produced during laser treatment of tissue. The rapid smoke evacuation is achieved by coupling a low capacity vacuum pump to a vacuum valve and a vacuum reservoir to create very high flow rate for very short durations. The opening time of the valve could at least partially overlap the laser pulse duration. 1. A rapid pulsatile smoke extraction system comprising:a laser handpiece terminated by a sleeve configurable for application to a patient skin;a laser providing laser energy from to laser handpiece;a reservoir containing air at a reduced pressure, the reservoir is in fluid communication with the sleeve;a valve configured to open and close communication between the sleeve and the reservoir; anda processor configurable to control operation of at least the valve; and wherein operation of the valve is synchronized with the operation of the laser.2. The system of wherein the valve opens communication between the sleeve and the reservoir just prior to start of a laser pulse and closes communication between the sleeve and the reservoir just after end of a laser pulse.3. The system of wherein the sleeve is a removable sleeve.4. The system of wherein the sleeve is a disposable sleeve.5. The system of wherein the sleeve when applied to skin forms a small confined\controlled volume.6. The system of wherein the sleeve is one of a group of sleeves consisting of a rigid sleeve and a flexible sleeve.7. The system of further including a vacuum pump configured to generate vacuum in at least the reservoir.8. The system of wherein the vacuum pump has a flow capacity of 0.5 liters per minute to 1000 liters per minute.9. The system of wherein the vacuum pump has a flow capacity 0.5 liters per minute to 50 liters per minute.10. The system of further comprising a smoke filter configured to filter smoke and particles generated by skin treatment procedures.11. The system of wherein the ...

Device And Method For Skin Treatment

A device and a method for fractional skin treatment. The device employs two diffractive optical elements. One of the diffractive optical elements provides two coaxial laser beams and another diffractive optical element splits the two coaxial laser beams into a plurality of beamlets. A lens arranged to receive the plurality of the laser beams and to focus them in a skin treatment plane. The lens forms an image where each of the beamlets is imaged as a spot with a high intensity central area and a lower intensity area surrounding the central area.

Applicator

Disclosed is an applicator or handpiece configured to apply treatment energy to a segment of skin located in a tissue or skin treatment plane. The treatment energy could be RF energy, applied by a pair of bipolar RF electrodes or optical energy. The applicator includes an optical system configured to form a rectangular spot and homogenize the optical energy distribution.

Laser System With Controlled Firing Of Cooling Agent And Laser Based On Applicator Position

A laser system includes a base unit having a power source. A hand-held applicator is connected with the base unit configured to engage biological tissue for treatment. Position detection structure is associated with the applicator for determining a position of the applicator relative to the engaged biological tissue. A laser source generates a laser beam. A cooling system provides a cooling agent to the biological tissue during treatment. A processor circuit is connected with the position detection structure, the laser source and the cooling system. Based on data received from the position detection structure, the processor circuit triggers application of the cooling agent to the treated biological tissue, or triggers application of the cooling agent to the treated biological tissue, followed by a time delay, and then triggers the laser source.

Pigment treatment system and methods of use thereof

A pigment treatment system includes a handheld apparatus to receive a sub-nanosecond laser beam with a wavelength of about 480 nm to about 550 nm and output a sub-nanosecond laser beam with a wavelength of about 700 nm to about 740 nm. The handheld apparatus includes a monolithic crystal with a first surface coating and a second surface coating to facilitate the change in wavelength of the laser beam through the crystal.

OPTICAL BIOPSIA TONGS

Optical biopsy forceps and method of diagnosing tissue

An integrated optical biopsy forceps device and a method for tissue identification by optical analysis and biopsy sampling at a site within the body. The device includes an elongated catheter body for introduction into the body and navigation to an area of interest. An optical fiber extends through the device, from the proximal end, where it may be connected to electro-optical spectral analysis equipment, to a distal tip for illuminating and receiving light energy from tissue at the location of the tip. The distal end of the device has a pair of cutting jaws pivotally mounted at the distal end of the catheter body and controlled by control wires extending through the catheter body to a control handle at the proximal end, or by the optical fiber. The device may be spectroscopically guided to a site of interest within the body. The fiber tip is positioned coaxially with the jaws at the zone of contact and cutting of the jaws, and is retracted as the jaws close, so that the biopsy sample is taken exactly at the spot being viewed by the optical fiber.

Cooling system for tissue treatment system with both tissue and light source cooling

A tissue treatment system includes an applicator connected with a base unit. The applicator includes a light source to generate light energy. A light guide directs the light energy to biological tissue and is configured to contact biological tissue. A thermoelectric cooler has a cold side and a hot side, with the cold side being associated with the light guide. A hot side plate is mounted to the hot side of the thermoelectric cooler. A first fluid passage is between the reservoir and the hot side plate to deliver cooling fluid over the hot side plate to chill the cold side of the thermoelectric cooler and cool the light guide and biological tissue. A second fluid passage is associated with the light source to direct cooling fluid to the light source prior to being returned to the reservoir. The first and second fluid passages define a single cooling fluid circulation loop.

Hyperspectral imaging in diabetes and peripheral vascular disease

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.

Devices for the treatment of biological tissue

An apparatus for treating a subcutaneous fat region is provided. The apparatus includes a housing that has a skin contacting portion defining a chamber. The apparatus also includes a first spaced region in the housing through which a coolant passes and a second spaced region in the housing that is at least partially evacuated of air. The apparatus further includes a source of electromagnetic radiation, a source of vacuum in fluid communication with the chamber, and a source for the coolant.

Optical biopsy forceps

Hyperspectral imaging in diabetes and peripheral vascular disease

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.

Optical biopsy forceps and methods of diagnosing tissue

An integrated optical biopsy forceps device (10) and a method for tissue identification by optical analysis and biopsy sampling at a site within the body. The device includes an elongated catheter body for introduction into the body and navigation to an area of interest. An optical fiber (50) extends through the device, from the proximal end, where it may be connected to electro-optical spectral analysis equipment, to a distal tip for illuminating and receiving light energy from tissue at the location of the tip. The distal end of the device has a pair of cutting jaws (80, 81) pivotally mounted at the distal end of the catheter body and controlled by control wires (40, 41) extending through the catheter body to a control handle at the proximal end, or by the optical fiber. The device may be spectroscopically guided to a site of interest within the body. The fiber tip (50) is positioned coaxially with the jaws at the zone of contact and cutting of the jaws, and is retracted as the jaws close, so that the biopsy sample is taken exactly at the spot being viewed by the optical fiber.

Reduction of RF electrode edge effect

A skin surface is treated with RF energy (e.g., unipolar, monopolar, bipolar or multipolar RF delivery). A first semiconductive cap disposed on a first distal end of a first electrode and, optionally, a second semiconductive cap disposed on a second distal end of a second electrode are applied to the skin surface. RF energy is delivered from the first electrode and the second electrode through the first semiconductive cap and the second semiconductive cap, respectively, through the skin surface. The first semiconductive cap and/or the second semiconductive cap have an electrical conductivity matched or substantially matched to the skin's electrical conductivity (e.g., about 0.1 to about 2 times that of the skin).

Method and apparatus for identifying spectral artifacts

The invention provides an apparatus and methods for determining whether spectral data obtained from a region of a tissue sample (402) are affected by an artifact. Artifacts include, for example, lighting artifacts such as glare and shadow and obstruction artifacts, such as blood, a speculum, a smoke tube, or other obstruction. Additionally, the invention provides an apparatus and methods for obtaining redundant spectral data of a given region of a sample (402). A redundant set of spectral data is useful where one or more artifacts affect some but not all sets of the spectral data, such that the redundant set of data is unaffected by the artifact and is representative of the tissue. An embodiment of the invention comprises using representative spectral data in diagnosing a condition of a region of tissue (402).

Method of treating tissue

A method of and apparatus for treating tissue wherein a handpiece with a cartridge of motor driven needles is placed in contact with tissue. The motor is energized to drive the needles. Energy is applied energy to the needles. Tissue impedance at the start of treatment is measured. Tissue impedance at the end of treatment is measured. The operator is then notified that corrective action is needed if the measured ending impedance is higher than the measured starting impedance indicating the needles are not inserted into the tissue.

Hyperspectral imaging in diabetes and peripheral vascular disease

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.

Methods and apparatus for characterization of tissue samples

The invention provides a system (100) and methods for in-situ identification of one or more regions of tissue (138) at which thee is a likelihood of disease. The invention generally relates to methods and devices for acquiring, analyzing, processing, and displaying optical data and diagnostic results from a patient sample. For example, methods of the invention comprise obtaining spectral and visual data from a patient sample, calibrating the data, compensating for sample motion, arbitrating between redundant data sets, identifying potentially non-representative data, analyzing the data, and displaying the diagnosic results. The invention provides the option of real-time data processing and diagnosis.

Hyperspectral imaging in diabetes and peripheral vascular disease

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.

Methods and apparatus for characterization of tissue samples

The invention provides a system (100) and methods for in-situ identification of one or more regions of tissue (138) at which thee is a likelihood of disease. The invention generally relates to methods and devices for acquirin g, analyzing, processing, and displaying optical data and diagnostic results fr om a patient sample. For example, methods of the invention comprise obtaining spectral and visual data from a patient sample, calibrating the data, compensating for sample motion, arbitrating between redundant data sets, identifying potentially non-representative data, analyzing the data, and displaying the diagnosic results. The invention provides the option of real- time data processing and diagnosis.

A system and diagnostic method for optical detection of suspect portions of a tissue sample

The invention provides systems (102) for automatically localizing areas of disease within a tissue sample using fluorescence spectra, reflectance spectra, and video images (102) obtained from the sample. The invention further provides systems for displaying (138), marking, and treating the identified areas so that healthy surrounding tissue suffers minimal impact upon treatment and/or excision of the diseased tissue (104). The invention facilitates minimally-invasive treatment by accurately directing treatment to only those areas that are identified as diseased.

Optical biopsy forceps and methods of diagnosing tissue

An integrated optical biopsy forceps device (10) and a method for tissue identification by optical analysis and biopsy sampling at a site within the body. The device includes an elongated catheter body for introduction into the body and navigation to an area of interest. An optical fiber (50) extends through the device, from the proximal end, where it may be connected to electro-optical spectral analysis equipment, to a distal tip for illuminating and receiving light energy from tissue at the location of the tip. The distal end of the device has a pair of cutting jaws (80, 81) pivotally mounted at the distal end of the catheter body and controlled by control wires (40, 41) extending through the catheter body to a control handle at the proximal end, or by the optical fiber. The device may be spectroscopically guided to a site of interest within the body. The fiber tip (50) is positioned coaxially with the jaws at the zone of contact and cutting of the jaws, and is retracted as the jaws close, so that the biopsy sample is taken exactly at the spot being viewed by the optical fiber.

Method and apparatus for identifying spectral artifacts

The invention provides an apparatus and methods for determining whether spectral data obtained from a region of a tissue sample (402) are affected b y an artifact. Artifacts include, for example, lighting artifacts such as glar e and shadow and obstruction artifacts, such as blood, a speculum, a smoke tub e, or other obstruction. Additionally, the invention provides an apparatus and methods for obtaining redundant spectral data of a given region of a sample (402). A redundant set of spectral data is useful where one or more artifact s affect some but not all sets of the spectral data, such that the redundant s et of data is unaffected by the artifact and is representative of the tissue. A n embodiment of the invention comprises using representative spectral data in diagnosing a condition of a region of tissue (402).

Method and apparatus for identifying spectral artifacts

The invention provides an apparatus and methods for determining whether spectral data obtained from a region of a tissue sample (402) are affected by an artifact. Artifacts include, for example, lighting artifacts such as glare and shadow and obstruction artifacts, such as blood, a speculum, a smoke tube, or other obstruction. Additionally, the invention provides an apparatus and methods for obtaining redundant spectral data of a given region of a sample (402). A redundant set of spectral data is useful where one or more artifacts affect some but not all sets of the spectral data, such that the redundant set of data is unaffected by the artifact and is representative of the tissue. An embodiment of the invention comprises using representative spectral data in diagnosing a condition of a region of tissue (402).

Smoke evacuation system

Smoke evacuation system for removal of aerosolized chemical compounds and biological fine particles produced during laser treatment of tissue. The rapid smoke evacuation is achieved by coupling a low capacity vacuum pump to a vacuum valve and a vacuum reservoir to create very high flow rate for very short durations. The opening time of the valve could at least partially overlap the laser pulse duration.

Monopolar rf subcutaneous fat treatment systems and methods

Methods and apparatus for processing spectral data for use in tissue characterization

The invention provides methods for processing tissue-derived spectral data for use in a tissue classification algorithm. Methods of the invention comprise application of spectral and/or image masks for automatically separating ambiguous or unclassifiable spectral data from valid spectral data. The invention improves the accuracy of tissue classification, in part, by properly identifying and accounting for spectral data from tissue regions that are affected by an obstruction and/or regions that lie outside a diagnostic zone of interest.

Monopolar rf subcutaneous fat treatment systems and methods

A subcutaneous fat treatment system and method. An electrode is for application to a patient's epidermis above subcutaneous fat to be treated, There may optionally be a cooling subsystem for cooling the electrode. A sensor such as a microwave radiometer measures the temperature of the subcutaneous fat to be treated. In addition or In the alternative, a subcutaneous fat thickness measurement may be used. A radio frequency source is for applying radio frequency energy to the electrode, A controller subsystem is responsive to the sensor and/or the subcutaneous fat thickness measurement and controls the radio frequency source to determine the thermal dose applied to the subcutaneous fat being treated and automatically adjust the radio frequency energy supplied to the electrode subjecting the subcutaneous fat to a thermal dose of between 0.1 and 10.0.

Optische biopsiezangen

Smoke evacuation system

Smoke evacuation system for removal of aerosolized chemical compounds and biological fine particles produced during laser treatment of tissue. The rapid smoke evacuation is achieved by coupling a low capacity vacuum pump to a vacuum valve and a vacuum reservoir to create very high flow rate for very short durations. The opening time of the valve could at least partially overlap the laser pulse duration.

Passive high energy q-switched laser system with optically synchronized multi-stage/multi-pass amplification

A sub-nanosecond laser system is disclosed. The sub-nanosecond laser system may include: a pump laser source operable to generate a pump laser beam having a pump wavelength; a first pump beam splitter operable to receive the pump laser beam and split the pump laser beam into at least a first split pump laser beam and a second split pump laser beam; a passively Q-switched seed laser operable to receive the first split pump laser beam and generate a seed laser beam; and an amplifier assembly operable to receive the second split pump laser beam and the seed laser beam. The amplifier assembly may include one or more amplifiers arranged in series in a multi-stage configuration, arranged in a multi-pass configuration, or a combination thereof.

Passive high energy q-switched laser system with optically synchronized multi-stage/multi-pass amplification

A sub-nanosecond laser system is disclosed. The sub-nanosecond laser system may include: a pump laser source operable to generate a pump laser beam having a pump wavelength; a first pump beam splitter operable to receive the pump laser beam and split the pump laser beam into at least a first split pump laser beam and a second split pump laser beam; a passively Q-switched seed laser operable to receive the first split pump laser beam and generate a seed laser beam; and an amplifier assembly operable to receive the second split pump laser beam and the seed laser beam. The amplifier assembly may include one or more amplifiers arranged in series in a multi-stage configuration, arranged in a multi-pass configuration, or a combination thereof.

System und diagnoseverfahren zur optischen detektion von verdächtigen stellen einer gewebeprobe

Applicator for cooling skin during irradiation

Disclosed is an applicator or handpiece configured to apply treatment energy to a segment of skin located in a tissue or skin treatment plane. The treatment energy could be RF energy, applied by a pair of bipolar RF electrodes or optical energy. The applicator includes an optical system configured to form a rectangular spot and homogenize the optical energy distribution.

Laser system with controlled firing of cooling agent and laser based on applicator position

A laser system includes a base unit having a power source. A hand-held applicator is connected with the base unit configured to engage biological tissue for treatment. Position detection structure is associated with the applicator for determining a position of the applicator relative to the engaged biological tissue. A laser source generates a laser beam. A cooling system provides a cooling agent to the biological tissue during treatment. A processor circuit is connected with the position detection structure, the laser source and the cooling system. Based on data received from the position detection structure, the processor circuit triggers application of the cooling agent to the treated biological tissue, or triggers application of the cooling agent to the treated biological tissue, followed by a time delay, and then triggers the laser source.

Laser system with controlled firing of cooling agent and laser based on applicator position

A laser system includes a base unit having a power source. A hand-held applicator is connected with the base unit configured to engage biological tissue for treatment. Position detection structure is associated with the applicator for determining a position of the applicator relative to the engaged biological tissue. A laser source generates a laser beam. A cooling system provides a cooling agent to the biological tissue during treatment. A processor circuit is connected with the position detection structure, the laser source and the cooling system. Based on data received from the position detection structure, the processor circuit triggers application of the cooling agent to the treated biological tissue, or triggers application of the cooling agent to the treated biological tissue, followed by a time delay, and then triggers the laser source.

Laser system with controlled firing of cooling agent and laser based on applicator position

A laser system includes a base unit having a power source. A hand-held applicator is connected with the base unit configured to engage biological tissue for treatment. Position detection structure is associated with the applicator for determining a position of the applicator relative to the engaged biological tissue. A laser source generates a laser beam. A cooling system provides a cooling agent to the biological tissue during treatment. A processor circuit is connected with the position detection structure, the laser source and the cooling system. Based on data received from the position detection structure, the processor circuit triggers application of the cooling agent to the treated biological tissue, or triggers application of the cooling agent to the treated biological tissue, followed by a time delay, and then triggers the laser source.

Fractional handpiece with a passively q-switched laser assembly field

A fractional handpiece and systems thereof for skin treatment include a passively Q-switched laser assembly operatively connected to a pump laser source to receive a pump laser beam having a first wavelength and a beam splitting assembly operable to split a solid beam emitted by the passively Q-switched laser assembly and form an array of micro-beams across a segment of skin. The passively Q-switched laser assembly generates a high power sub-nanosecond pulsed laser beam having a second wavelength.

Laser system with controlled firing of cooling agent and laser based on applicator position

The disclosure relates to a laser system includes a base unit having a power source. A hand-held applicator is connected with the base unit configured to engage biological tissue for treatment. Position detection structure is associated with the applicator for determining a position of the applicator relative to the engaged biological tissue. A laser source generates a laser beam. A cooling system provides a cooling agent to the biological tissue during treatment. A processor circuit is connected with the position detection structure, the laser source and the cooling system. Based on data received from the position detection structure, the processor circuit triggers application of the cooling agent to the treated biological tissue, or triggers application of the cooling agent to the treated biological tissue, followed by a time delay, and then triggers the laser source.

Sistema de evacuación de humos

Sistema de evacuación de humos para la eliminación de compuestos químicos en aerosol y partículas finas biológicas producidas durante el tratamiento con láser de tejidos. La rápida evacuación de humo se logra acoplando una bomba de vacío de baja capacidad a una válvula de vacío y un depósito de vacío para crear un caudal muy alto durante periodos de tiempo muy cortos. El tiempo de apertura de la válvula podría solaparse al menos parcialmente con la duración del impulso láser. (Traducción automática con Google Translate, sin valor legal)

Smoke Evacuation System

A rapid pulsatile smoke extraction system includes a laser handpiece having a sleeve configurable to be applied to tissue; a vacuum pump and a vacuum reservoir; a conduit connecting the reservoir with the sleeve; and a valve inserted in the conduit. A volume of the vacuum reservoir is at least two times larger than a volume of the sleeve, such that operation of the valve supports instantaneous evacuation of smoke and particulate products from the sleeve into the vacuum reservoir.

Laser system with controlled firing of cooling agent and laser based on applicator position

The disclosure relates to a laser system includes a base unit having a power source. A hand-held applicator is connected with the base unit configured to engage biological tissue for treatment. Position detection structure is associated with the applicator for determining a position of the applicator relative to the engaged biological tissue. A laser source generates a laser beam. A cooling system provides a cooling agent to the biological tissue during treatment. A processor circuit is connected with the position detection structure, the laser source and the cooling system. Based on data received from the position detection structure, the processor circuit triggers application of the cooling agent to the treated biological tissue, or triggers application of the cooling agent to the treated biological tissue, followed by a time delay, and then triggers the laser source.

A method of treating tissue

A method of and apparatus for treating tissue wherein a handpiece with a cartridge of motor driven needles is placed in contact with tissue. The motor is energized to drive the needles. Energy is applied energy to the needles. Tissue impedance at the start of treatment is measured. Tissue impedance at the end of treatment is measured. The operator is then notified that corrective action is needed if the measured ending impedance is higher than the measured starting impedance indicating the needles are not inserted into the tissue.

Cryogenic cylinder and skin treatment device

A cryogenic cylinder including authenticating features and an apparatus recognizing the features and facilitation the cylinder use. The authenticating features prevent use of an unauthorized cryogenic cylinders. The cylinder also includes a number of mechanical features preventing repeat filling of the cylinder by cryogenic fluid or reuse of the cylinder once empty.

Cryogenic cylinder and skin treatment device

A cryogenic cylinder including authenticating features and an apparatus recognizing the features and facilitation the cylinder use. The authenticating features prevent use of an unauthorized cryogenic cylinders. The cylinder also includes a number of mechanical features preventing repeat filling of the cylinder by cryogenic fluid or reuse of the cylinder once empty.

Fractional handpiece with a passively Q-switched laser assembly field

A fractional handpiece and systems thereof for skin treatment include a passively Q-switched laser assembly operatively connected to a pump laser source to receive a pump laser beam having a first wavelength and a beam splitting assembly operable to split a solid beam emitted by the passively Q-switched laser assembly and form an array of micro-beams across a segment of skin. The passively Q-switched laser assembly generates a high power sub-nanosecond pulsed laser beam having a second wavelength.

Fractional handpiece with a passively q-switched laser assembly field

A fractional handpiece and systems thereof for skin treatment include a passively Q-switched laser assembly operatively connected to a pump laser source to receive a pump laser beam having a first wavelength and a beam splitting assembly operable to split a solid beam emitted by the passively Q-switched laser assembly and form an array of micro-beams across a segment of skin. The passively Q-switched laser assembly generates a high power sub-nanosecond pulsed laser beam having a second wavelength.

Fractional handpiece with a passively q-switched laser assembly field

Optimal windows for obtaining optical data for characterization of tissue samples

The invention provides methods for determining a characteristic of a tissue sample, such as a state of health, using spectral data and/or images obtained within an optimal period of time following the application of a chemical agent to the tissue sample. The invention provides methods of determining such optimal windows of time. Similarly, the invention provides methods of determining other criteria for triggering the acquisition of an optical signal for classifying the state of health of a region of a tissue sample.

Applicator

Disclosed is an applicator or handpiece configured to apply treatment energy to a segment of skin located in a tissue or skin treatment plane. The treatment energy could be RF energy, applied by a pair of bipolar RF electrodes or optical energy. The applicator includes an optical system configured to form a rectangular spot and homogenize the optical energy distribution.

Optimal time windows for obtaining optical data for characterization of tissue samples

The invention provides methods for determining a characteristic of a tissue sample, such as a state of health, using spectral data and/or images obtained within an optimal period of time following the application of a chemical agent to the tissue sample. The invention provides methods of determining such optimal windows of time. Similarly, the invention provides methods of determining other criteria for triggering the acquisition of an optical signal for classifying the state of health of a region of a tissue sample.

Smoke evacuation system

Optimal time windows for obtaining optical data for characterization of tissue samples

Optimal windows for obtaining optical data for characterization of tissue samples

Multiple frequency laser system for treating skin conditions

A multiple frequency laser system and method for treating skin conditions via a handpiece features a pump laser module having a single laser beam at a first frequency. A dual laser module receives the laser beam at the first frequency and includes dual free running laser resonators to produce a laser beam at a second frequency and a laser beam at a third frequency. A frequency conversion module receives as inputs the laser beam at the second frequency and the laser beam at the third frequency and is configured to selectively provide laser beams to the handpiece including a second harmonic generation of the second frequency, a second harmonic generation of the third frequency, a summed frequency generation of the second frequency and the third frequency, the laser beam at the first frequency, the laser beam at the second frequency, and/or the laser beam at the first frequency combined with the laser beam at the second frequency. The handpiece receives the laser beams from the frequency module and delivers them to skin for treatment.

Hand-held applicator with controlled firing of cooling agent and laser based on applicator position

Fractional handpiece with a passively q-switched laser assembly

A fractional handpiece and systems thereof for skin treatment including a handpiece body including a passively Q-switched laser assembly within the handpiece body operatively connected to a pump laser source to receive a pump laser beam having a first wavelength and a beam scanning system operable to scan a solid beam emitted by the passively Q-switched laser assembly and form a line of micro-beams across a segment of skin. The passively Q-switched laser assembly generates a high-power sub-nanosecond pulsed laser beam having a second wavelength. The pump laser source is a diode laser which emits the first wavelength at about 500 nm to about 1000 nm.

Multiple frequency laser system for treating skin conditions

A multiple frequency laser system and method for treating skin conditions via a handpiece features a pump laser module having a single laser beam at a first frequency. A dual laser module receives the laser beam at the first frequency and includes dual free miming laser resonators to produce a laser beam at a second frequency and a laser beam at a third frequency. A frequency conversion module receives as inputs the laser beam at the second frequency and the laser beam at the third frequency and is configured to selectively provide laser beams to the handpiece including a second harmonic generation of the second frequency, a second harmonic generation of the third frequency, a summed frequency generation of the second frequency and the third frequency, the laser beam at the first frequency, the laser beam at the second frequency, and/or the laser beam at the first frequency combined with the laser beam at the second frequency. The handpiece receives the laser beams from the frequency module and delivers them to skin for treatment.

Reduction of pain through lower fluence rates and longer treatment

A method of treating a subcutaneous fat region is provided. The method includes generating electromagnetic radiation having a wavelength of about 1,200 nm to about 1,230 nm and delivering an average power density of less than or equal to about 2.3 W/cm 2 of the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds. The method also includes cooling an epidermal region and at least a portion of a dermal region overlying the subcutaneous fat region for at least a portion of the at least 300 seconds. The method further includes causing necrosis of at least one fat cell in the subcutaneous fat region.

Reduction of RF electrode edge effect

A skin surface is treated with bipolar RF energy. A first semiconductive cap disposed on a first distal end of a first electrode and a second semiconductive cap disposed on a second distal end of a second electrode are applied to the skin surface. RF energy is delivered from the first electrode and the second electrode through the first semiconductive cap and the second semiconductive cap, respectively, through the skin surface. A thickness of each semiconductive cap between a blunt skin contacting surface and a curved surface affixed to a respective electrode is thicker at an inner portion and thinner at a center portion to homogenize the electrical field at the skin surface.