УСТРОЙСТВО И СПОСОБ ДЛЯ ИЗМЕРЕНИЯ ГЕМОДИНАМИЧЕСКИХ ПАРАМЕТРОВ

Изобретение относится к медицинской технике, а именно к устройствам и способам для комплексного обследования сердечно-сосудистой системы. Устройство для измерения гемодинамических характеристик, в частности показателя увеличения аорты (AIx) и/или длительности выброса (ED) посредством неинвазивного, основанного на манжете окклюзивного измерения кровяного давления, содержит окклюзивный, осциллометрический автоматический измеритель кровяного давления и блоки определения величины гемодинамических параметров, включающие арифметический блок вычисления амплитуды, определяющий индекс аугментации (AIx), детектор разделения и хранения сигналов осцилляционнонй волны, выполненный с частотой дискретизации, по меньшей мере, 200 выборок за один сердечный цикл, блок памяти, разрешение которого организовано, по меньшей мере, с 9 битами, блок синтеза, выполненный с возможностью определения длительности выброса (ED). Арифметический блок вычисления амплитуды и блок синтеза соединены в общий программный контроллер ...

ГЕМОДИНАМИЧЕСКИЕ МОНИТОРЫ И УСТРОЙСТВА ТРЕВОЖНОЙ СИГНАЛИЗАЦИИ

Изобретение относится к медицинской технике, а именно к системам медицинского контроля. Прибор для гемодинамического мониторирования содержит процессор и устройство вывода с устройством тревожной сигнализации. Процессор выполнен с возможностью получения физиологических параметров, характеризующих частоту сердечных сокращений и артериальное давление, и вычисления гемодинамического параметра в соответствии с системным сосудистым сопротивлением (SVR). В способе мониторирования вычисленный количественный гемодинамический параметр количественно выражает эвристическое правило «количественный измеренный показатель АВР является низким, И количественный измеренный показатель HR является немного повышенным или высоким», ИЛИ «количественный измеренный показатель АВР является очень низким», при этом при его вычислении определяют первую нечеткую переменную, указывающую, является ли количественный измеренный показатель HR немного повышенным или высоким, вторую нечеткую переменную, указывающую, является ...

Система поддержки принятия клинических решений на основе принятия решений по сортировке пациентов

Группа изобретений относится к медицине, а именно к системе поддержки принятия клинических решений на основе принятия решений по сортировке пациентов. Система поддержки принятия клинических решений, содержащая машиночитаемый носитель данных для поддержки принятия клинических решений, закодированный машиночитаемыми командами для выполнения способа, причем система содержит вычислительную систему, которая включает в себя: по меньшей мере один вычислительный процессор; средства ввода/вывода и машиночитаемый носитель данных, закодированный модулем сортировки пациентов, при этом средства ввода/вывода выполнены с возможностью приема электрического сигнала, который включает в себя набор по меньшей мере двух измеренных физиологических параметров пациента, причем измерения одного и того же физиологического показателя выполнены в разных местах тела пациента; и по меньшей мере один вычислительный процессор выполнен с возможностью выполнения команд модуля сортировки пациентов, которые включают: сравнение ...

СИСТЕМА И СПОСОБ ОПРЕДЕЛЕНИЯ КОЛИЧЕСТВЕННОГО ПОКАЗАТЕЛЯ РИСКА ГЕМОДИНАМИЧЕСКОЙ НЕСТАБИЛЬНОСТИ У ПЕДИАТРИЧЕСКИХ СУБЪЕКТОВ

СПОСОБ ИЗМЕРЕНИЯ ВРЕМЕНИ НАПОЛНЕНИЯ КАПИЛЛЯРОВ

Способ определения нарушений авторегуляции мозгового кровотока

METHOD FOR ESTIMATION OF BRAIN BLOODSTREAM AUTOREGISTRATION OF NEUROSURGICAL PATIENTS

System zum patientenspezifischen Modellieren von Blutfluss

System zum Bestimmen von kardiovaskulären Informationen für einen Patienten, wobei das System Folgendes umfasst: wenigstens ein Computersystem, das konfiguriert ist, um: patientenspezifische Daten bezüglich einer Geometrie einer anatomischen Struktur des Patienten zu empfangen, wobei die anatomische Struktur wenigstens einen Abschnitt einer Mehrzahl an Koronararterien, die von einer Aorta ausgehen, beinhaltet; basierend auf den patientenspezifischen Daten ein dreidimensionales Modell zu erzeugen, das einen ersten Abschnitt der anatomischen Struktur repräsentiert, wobei der erste Abschnitt der anatomischen Struktur wenigstens den Abschnitt der Mehrzahl an Koronararterien beinhaltet; wenigstens teilweise basierend auf einer Masse oder einem Volumen des Myokardgewebes ein physikbasiertes Modell bezüglich einer Blutflusseigenschaft im ersten Abschnitt der anatomischen Struktur zu erzeugen; und wenigstens teilweise basierend auf dem dreidimensionalen Modell und dem physikbasierten Modell eine ...

MESSUNG DER HERZFUNKTION

Implantable medical apparatus with electrical stimulation unit, e.g. responding to sleep apnea, has position sensor connected with signal input of sleep detector unit to modify operation according to inclination

The Medical apparatus for body implantation including an electrical stimulation unit providing an electrical signal indicating sleep apnea, a sleep detector unit, an apnea detector unit which gives an apnea signal, a therapy unit connected to the stimulation, sleep detector, and apnea detector units, which gives at least one apnea signal, sending therapy information for prevention and/or treatment of sleep apnea, which is sent to the stimulation unit. Independent claims are included for: (1) a home monitoring system including a medical implantation device and a mobile patient application device connected to it; and (2) a patient supervision system including a device which can be connected to the apparatus and a central service center for transfer of patient data via a network system to the mobile patient application device .

VORRICHTUNG ZUR TRENDANALYSE EINES PHYSIOLOGISCHEN HERZPARAMETERS

A hemodynamic monitor and method of hemodynamic monitoring

Microparticle compositions

GERÄT ZUR MESSUNG VON HERZ- UND GEFÄSSFUNKTION (FUNCTION) UND KÖRPERRÄUMEN (SPACES) MIT HILFE DER IMPEDANZMESSUNG

At an electric instrument used for the measurement of heart- and vascular function as well as body spaces, which is based on impedance measurement, the position of the electrodes, body volume and the volume of the segments located between the electrodes are measured with the help of a contactless measuring apparatus. The instrument comprises a plurality of electrodes capable of being attached to a body, a reference surface on which the body may be placed, and an electrical impedance meter capable of measuring the bodily functions of the body by measuring the electrical impedance and estimating the shape of the body by locating the electrodes attached to the body with reference to the reference surface, wherein the measured electrical impedance is associated with the estimated shape of the body segment.

GERÄT ZUR MESSUNG VON HERZ- UND GEFÄSSFUNKTION (FUNCTION) UND KÖRPERRÄUMEN (SPACES) MIT HILFE DER IMPEDANZMESSUNG

Measurement of total body volume or its segments distinctly improves interpretation of measured electrical parameters, above all when electrical measurements are taken at several frequencies and in more than one direction (e.g. longitudinally and transversely) in approximately cylindrical segments. A remote measuring device is used for recording body surface along with a measuring carriage (15). An independent claim is also included for a method for electrical measurement of body functions and conditions ...

DEVICE FOR THE EVALUATION OF THE HÄMODYNAMI CONDITION OF A PERSON OF MEANS HEART LUNG INTERACTION

EQUIPMENT FOR THE DIAGNOSIS AND MONITORING OF THE CONDITION OF THE VEGETATIVE NERVOUS SYSTEM AS WELL AS FOR THE TREATMENT OF DISEASES AND SUFFERING DUE TO HORMONE DISTURBANCES

Patient-specific modeling of hemodynamic parameters in coronary arteries

Systems, methods, and computer-readable media are disclosed for patient-specific modeling of hemodynamic parameters in coronary arteries. Example methods may include performing computational fluid dynamics simulations using a patient-specific coronary artery anatomical model derived from medical imaging data and patient-specific boundary conditions derived from a continuously recorded blood pressure waveform to determine patient-specific hemodynamic parameters in a patient's coronary arteries.

Multiparameter whole blood monitor and method

Method and system for monitoring hemodynamics

A system for monitoring hemodynamics of a subject is disclosed. The system comprises: a signal generating system configured for providing at least an output electric signal and transmitting the output signal to an organ of the subject. The system also comprises a demodulation system configured for receiving an input electrical signal sensed from the organ responsively to the output electric signal, and for modulating the input signal using the output signal to provide an in-phase component and a quadrature component of the input signal. The system also comprises a processing system configured for monitoring the hemodynamics based on the in-phase and the quadrature components.

Apparatus and method for non-invasive thoracic radio interrogation

Combination heart assist systems, methods, and devices

The various embodiments disclosed herein relate to combination heart assist systems, methods, and devices that include both an electrical therapy device and a mechanical heart assist device. Various operational modes can be implemented using these embodiments, including a synchronized pacing mode, an internal CPR mode, and an internal workout mode.

A method and system for determining a cerebrovascular autoregulation state of a patient

Method and system for non-invasively monitoring biological or biochemical parameters of individual

A system and method are presented for use in monitoring one or more conditions of a subject's body. The system comprises a control unit which comprises an input port for receiving image data and data indicative of at least one external stimulation (external field) applied to a portion of the subject's body during collection of the image data therefrom, a memory utility, and a processor utility. The image data is indicative of a sequence of speckle patterns generated by the portion of the subject's body according to a certain sampling time pattern. The processor utility is configured and operable for carrying out the following: processing the image data utilizing the data indicative of the applied external field(s), said processing comprising determining a spatial correlation function between successive speckle patterns in the sequence, and determining a time varying spatial correlation function in the form of a time-varying function of at least one feature of the correlation function indicative ...

Cardiac function evaluation system

A device adapted for determining cardiac viability, wherein said device includes: a cannula having a hollow body and at least a distal end adapted for insertion into a heart and operator end for adapted for an operator to position the catheter in the ventricular apex and adapted for connection to a plumbing system; an inflatable balloon positioned near to the distal end in fluid communication with the hollow body to allow for selected inflation of the balloon, a controller adapted to calculate the viability of the heart from pressure data detected within cannula or balloon which is inflated to various degrees with an incompressible fluid.

Baroreceptor mapping system

A system including a mapping device, a stimulator, and a marker. The mapping device includes a plurality of electrodes to be situated on a baroreceptor region of a patient to map baroreceptors in the baroreceptor region. The stimulator is to stimulate selected electrodes of the plurality of electrodes to obtain physiological responses from the patient in response to stimulation of the selected electrodes. The marker is to be attached to the patient to mark a location of at least one of the selected electrodes based on an analysis of the physiological responses from the patient, where the marker is to maintain its location on the patient as the mapping device is removed from the patient.

Method and system for patient-specific modeling of blood flow

C:\Users\kll\AppData\Local\Temp12713 IDAOBAFC.DOCX-22 12/2015 Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Method and system for patient-specific modeling of blood flow

Abstract A system for determining cardiovascular information for a patient, the system comprising: at least one computer system configured to: receive patient specific data regarding a geometry of an anatomical structure of the patient; create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, the three-dimensional model representing at least one fluid flow inlet and at least one fluid flow outlet; create at least one boundary condition model representing fluid flow through at least one of the at least one inlet or the at least one outlet, based at least in part on modeling a condition of hyperemia; and determine first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three dimensional model and the at least one boundary condition model. cCD Co co VC C C) C) f I co C, Loij 0~ u~ EtIt C3oI ...

SYSTEM AND METHOD FOR BIOMETRIC IDENTIFICATION USING SLEEP PHYSIOLOGY

The claimed invention comprises software methods for user continuity and physiological state change assessments through generating biometric profiles of individuals and/or groups of individuals by using physiological input together with biomathematical modeling and machine learning techniques. Intra-individual variation in physiological variables including, but not limited to: heart rate, heart rate variability, pulse waveform and its derivatives, blood pressure, breathing rate, cardiopulmonary coupling, actigraphy and circadian rhythms characteristics, are exploited.

METHOD AND SYSTEM FOR NON-INVASIVELY MONITORING BIOLOGICAL OR BIOCHEMICAL PARAMETERS OF INDIVIDUAL

A system and method are presented for use in monitoring one or more conditions of a subject's body. The system comprises a control unit which comprises an input port for receiving image data and data indicative of at least one external stimulation (external field) applied to a portion of the subject's body during collection of the image data therefrom, a memory utility, and a processor utility. The image data is indicative of a sequence of speckle patterns generated by the portion of the subject's body according to a certain sampling time pattern. The processor utility is configured and operable for carrying out the following: processing the image data utilizing the data indicative of the applied external field(s), said processing comprising determining a spatial correlation function between successive speckle patterns in the sequence, and determining a time varying spatial correlation function in the form of a time-varying function of at least one feature of the correlation function indicative ...

PHYSIOLOGICAL SENSOR DELIVERY DEVICE AND METHOD

An intravaseular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve. For example, such a device may be used to measure fractional flow reserve (FFR) across a stenotic lesion in order to assess the severity of the lesion. The sensor delivery device has a distal sleeve configured to pass or slide over a standard medical guidewire. Some distance back from the sensor and distal sleeve, the device separates from the guidewire to permit independent control of the sensor delivery device and the guidewire. The sensor delivery device can be sized to pass over different sizes of guidewires to enable usage in coronary and peripheral arteries, for example.

SYSTEMS AND METHODS FOR RECORDING SIMULTANEOUSLY VISIBLE LIGHT IMAGE AND INFRARED LIGHT IMAGE FROM FLUOROPHORES

The invention provides systems and methods for imaging a sample. In various embodiments, the invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a visible light source, a notch beam splitter, a notch filter, a synchronization module, an image processing unit, an image displaying unit, and light-conducting channels. In various embodiments, the present invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a laser clean-up filter, a notch filter, a white light source, an image processing unit, an image displaying unit, and light-conducting channels. In accordance with the present invention, the image sensor can detect both visible light and infrared light.

CONFORMAL SENSOR SYSTEMS FOR SENSING AND ANALYSIS OF CARDIAC ACTIVITY

Systems, methods and apparatuses for monitoring cardiac activity of an individual using a conformal cardiac sensor device are presented herein. A conformal cardiac sensor device for analyzing cardiac activity includes a flexible substrate for coupling to the user, and a heart sensor component embedded on/in the substrate. The heart sensor component contacts a portion of the users skin and measures electrical variable(s) indicative of cardiac activity. A biometric sensor component is embedded on/in the flexible substrate and measures physiological variable(s) indicative of cardiac activity of the user. A microprocessor, which is embedded on/in the flexible substrate, is communicatively coupled to the heart sensor component and biometric sensor component and operable to execute microprocessor executable instructions for controlling the measurements of electrical data and physiological data. A wireless communication component is embedded on/in the flexible substrate and is operable to transmit ...

CALCULATING CARDIOVASCULAR PARAMETERS

Methods for measuring a cardiovascular parameter in a subject regardless of whether the subject is experiencing normal hemodynamic or abnormal hemodynamic conditions are described. These methods involve the determination of whether a subject is experiencing normal hemodynamic conditions or abnormal hemodynamic conditions, then applying an appropriate model to subject data to determine a cardiovascular parameter for the subject.. Multivariate Boolean models are used to establish if the subject is experiencing normal hemodynamic or abnormal hemodynamic conditions, then multivariate statistical models are used to calculate the appropriate cardiovascular parameter. Having correct cardiovascular parameters for a subject experiencing abnormal hemodynamic conditions, for example, enables the calculation of accurate values for treatment relevant parameters, such as, cardiac output and stroke volume.

SYSTEM AND PROCESS FOR ESTIMATING A QUANTITY OF INTEREST OF A DYNAMIC ARTERY/TISSUE/VEIN SYSTEM

L' invention concerne un système et un procédé pour estimer des paramètres hémodynamiques par application de méthodes probabilistes douces à l'imagerie de perfusion. Un tel procédé permet en outre d'estimer des fonctions de répartition complémentaire ou d'entrée artérielles et donc plus généralement toute quantité d'intérêt. L'invention se distingue notamment des procédés connus en ce quelle requière l'introduction a priori d' informations strictement douces de nature physiologique ou hémodynamique sans contraindre ni forcer l'estimation recherchée par des hypothèses arbitraires et indésirables.

METHOD AND APPARATUS FOR CARDIAC TISSUE MONITORING AND CATHETER-BASED PERFUSION FOR MITIGATING ACUTE REOXYGENATION INJURY

A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes or other ischemic conditions. A method and apparatus is described that allows mitigation of oxygcn-relatcd injury by precisely modulating the level of oxygen rc-cxposurc during rcoxygcnation by a controlled feedback loop based on parameters of the tissue measured by a real-time tissue sensor or probe.

METHOD AND SYSTEM FOR MONITORING HEMODYNAMICS

A system for monitoring hemodynamics of a subject is disclosed. The system comprises: a signal generating system configured for providing at least an output electric signal and transmitting the output signal to an organ of the subject. The system also comprises a demodulation system configured for receiving an input electrical signal sensed from the organ responsively to the output electric signal, and for modulating the input signal using the output signal to provide an in-phase component and a quadrature component of the input signal. The system also comprises a processing system configured for monitoring the hemodynamics based on the in-phase and the quadrature components.

METHODS FOR EVALUATING REGIONAL CARDIAC FUNCTION AND DYSSYNCHRONY FROM A DYNAMIC IMAGING MODALITY USING ENDOCARDIAL MOTION

An embodiment in accordance with the present invention provides a method and system for evaluating regional cardiac function and dyssynchrony from an imaging modality using the motion of endocardial features of the heart. In the method and system, an imaging modality such as a CT scanner is used to obtain an image sequence that is then processed using a computer program. The computer program is configured to create an endocardial mesh formed from triangular components that represents at least the region of interest of the subject's heart. From tracking the motion of conserved topological features on this endocardial mesh at least two time points a displacement map can be modeled. The displacement map can be further analyzed to determine metrics of regional cardiac function such as SQUEEZ, myocardial strain, torsion etc., and the displacement map can also be used to create visual representations of the function of the subject's heart.

Apparatus and method for processing of tomographic data.

Eine Vorrichtung und ein Verfahren (100) zur Verarbeitung von Daten (501), welche mittels eines bildgebenden Verfahrens gewonnen wurden, ermöglichen eine Verbesserung einer ortsspezifischen Visualisierung der Durchblutung der Lunge. Durch einen Bezug zu einer Vergleichsgrösse wird eine für einen Betrachtungszeitraum charakteristische ortsspezifische Grösse (503) hinsichtlich der Durchblutung von Lunge und Herzregion ermittelt und als ein Ausgangssignal bereitgestellt.

Apparatus and method for processing of tomographic data.

Eine Vorrichtung und ein Verfahren (100) zur Verarbeitung von Daten (501), welche mittels eines bildgebenden Verfahrens gewonnen wurden, ermöglichen eine Verbesserung einer ortsspezifischen Visualisierung der Durchblutung der Lunge. Durch einen Bezug zu einer Vergleichsgrösse wird eine für einen Betrachtungszeitraum charakteristische ortsspezifische Grösse (503) hinsichtlich der Durchblutung von Lunge und Herzregion ermittelt und als ein Ausgangssignal bereitgestellt.

СПОСОБ И СИСТЕМА ДЛЯ НЕИНВАЗИВНЫХ ИЗМЕРЕНИЙ ПАРАМЕТРОВ РАБОТЫ СЕРДЦА

Представлены способ и система для получения оценки по меньшей мере одного кардиального параметра индивидуума. На тело индивидуума накладывают комплект электродов с тем, чтобы приложить к телу электрическое поле и сформировать электрические выходные сигналы, характеризующие изменение систолического импеданса и скорости этого изменения во время сердечного цикла. Предусмотрено также получение дополнительных данных, по меньшей мере, характеризующих следующие параметры или состояние индивидуума: значение полного периферического сопротивления (TPR), значение сердечного индекса (Cl) и наличие состояния острой сердечной недостаточности (OCH). Эти дополнительные данные анализируют, чтобы определить, удовлетворяют ли значение TPR первому заданному условию и/или значение Cl второму заданному условию и/или выявлено ли состояние ОСН. С учетом этого определения используют данные, соответствующие измеренным электрическим сигналам, для селективного вычисления по меньшей мере одного кардиального параметра ...

СИСТЕМА ДЛЯ ДИАГНОСТИКИ РАССЕЯННОГО СКЛЕРОЗА

Система для определения по меньшей мере одного показателя из показателя рефлюкса крови и показателя повышенного сопротивления крови в церебральных венах у пациента, включающая набор источников выявления (TCCS, ECD) для выявления: i) рефлюкса крови по меньшей мере в одной из глубоких церебральных вен, ii) рефлюкса крови по меньшей мере в одной из внутренних яремных и/или позвоночных вен; iii) стеноза по меньшей мере в одной из внутренних яремных вен, iv) недостаточности выявляемого допплерографией кровотока по меньшей мере в одной из внутренней яремной и/или позвоночной вен; и v) отрицательной разности между площадью поперечного сечения по меньшей мере одной из внутренних яремных вен в положении лежа на спине и в положении стоя указанного пациента. Система, кроме того, включает модуль обработки (PC), функционально соединенный с указанным набором источников выявления (TCCS, ECD) для регистрации состояния, при котором по меньшей мере два из показателей с i) по v) положительны, так что модуль ...

СПОСОБ И СИСТЕМА ДЛЯ НЕИНВАЗИВНЫХ ИЗМЕРЕНИЙ ПАРАМЕТРОВ РАБОТЫ СЕРДЦА

Представлены способ и система для получения оценки по меньшей мере одного кардиального параметра индивидуума. На тело индивидуума накладывают комплект электродов с тем, чтобы приложить к телу электрическое поле и сформировать электрические выходные сигналы, характеризующие изменение систолического импеданса и скорости этого изменения во время сердечного цикла. Предусмотрено также получение дополнительных данных, по меньшей мере, характеризующих следующие параметры или состояние индивидуума: значение полного периферического сопротивления (TPR), значение сердечного индекса (CI) и наличие состояния острой сердечной недостаточности (ОСН). Эти дополнительные данные анализируют, чтобы определить, удовлетворяют ли значение TPR первому заданному условию и/или значение CI второму заданному условию и/или выявлено ли состояние ОСН. С учетом этого определения используют данные, соответствующие измеренным электрическим сигналам, для селективного вычисления по меньшей мере одного кардиального параметра ...

Method and apparatus for acquiring and analyzing data relating to a physiological condition of a subject

A method for locating and marking points on a waveform includes providing data corresponding to electrocardiogram and ballistocardiogram waveforms correlated in time, searching the data to locate points corresponding to cardiac events, a location of each of the points corresponding to cardiac events being defined by a rule set, identifying and storing the points corresponding to cardiac events and outputting a visual representation including the points corresponding to cardiac events marked on the electrocardiogram and ballistocardiogram waveforms.

METHOD AND SYSTEM FOR SENSITIVITY ANALYSIS IN MODELING BLOOD FLOW CHARACTERISTICS

Method for estimating hemodynamic perfusion parameters of elementary volume i.e. voxel of brain, involves estimating hemodynamic perfusion parameters by estimating conjunction of parameters of global perfusion model

L'invention concerne un procédé pour estimer des paramètres hémodynamiques de perfusion d'un volume élémentaire - dit voxel - d'un organe, à partir de signaux de perfusion par une estimation conjointe des paramètres d'un modèle global de perfusion contraint. L'invention concerne en outre une unité de traitement d'un système d'analyse d'imagerie de perfusion, adaptée pour mettre en œuvre un tel procédé et délivrer les paramètres estimés selon un format approprié à une interface homme-machine apte à restituer à un utilisateur lesdits paramètres estimés.

CARDIAC DEVICE

dispositivo distribuidor de sensor fisiológico e método

ECG Analysis for Diagnosis of Heart Failure and Cardiovascular Disease Using Signals Obtained from an implantable monitor

ECG Analysis for Diagnosis of Heart Failure and Cardiovascular Disease Using Signals Obtained from an implantable monitor 5 The disclosure relates to an implantable device (1) for monitoring of a patient’s electrocardiogram (ECG), the device (1) comprising a detection element (2) for determining electrocardiogram signals (S) of a heart (H) of the patient, which signals (S) are indicative of the electrocardiogram (ECG) of the patient, wherein the implantable device (1) comprises a processing unit (3) that is configured to determine from said signals 10 (S) at least one parameter of the electrocardiogram (ECG), wherein said at least one parameter is an R:S ratio (: ) defined as the ratio between the absolute value ( B JKLM B) of the R complex and the absolute value ( BJKLM B) of the S complex. Fig. 1 15 ...

METHOD AND SYSTEM FOR USING DISTRIBUTED ELECTROMAGNETIC (EM) TISSUE(S) MONITORING

A system for monitoring at least one biological tissue of a patient during a period of at least 24 hours. The system comprises an implantable intrabody probe and an extrabody probe which propagate an electromagnetic (EM) signal, using an antenna, via at least one tissue therebetween, in a plurality of sessions during a period of at least 24 hours, a processing unit which analyses the EM signal to detect a change in at least one biological parameter of the at least one tissue, and an output unit which outputs the change.

DIRECT MEASUREMENTS OF ARTERIAL PRESSURE DECOUPLING

Methods for monitoring central-to-peripheral arterial pressure decoupling, i.e., hyperdynamic or vasodilation conditions are described. These methods involve the comparison of parameters such as impedance, compliance, and pressure that can be determined from flow and pressure measurements at central aortic and peripheral arterial locations. The relationship between the parameters at the central aortic and peripheral arterial locations provides an indication of central-to-peripheral arterial pressure decoupling. These methods can be alert a user that a subject is experiencing central-to-peripheral arterial pressure decoupling, which can enable a clinician to appropriately provide treatment to the subject.

METHOD AND SYSTEM FOR DETERMINING CARDIAC FUNCTION

A method for determining a physiologic characteristic associated with cardiac function in a subject comprising the steps of providing at least one electromagnetic radiation absorption measurement, providing demographic information reflecting the subject's physical condition, determining a temporal plethysmography value from the electromagnetic radiation absorption measurement, and determining at least one physiologic characteristic from the temporal plethysmographic value and demographic information by using a predetermined phenomenological model that is adapted to provide an estimate of a blood volume-time relationship proximate the heart and compute at least one physiologic characteristic associated with cardiac function based on the estimated blood volume-time relationship.

SHAPE SENSING DEVICES FOR REAL-TIME MECHANICAL FUNCTION ASSESSMENT OF AN INTERNAL ORGAN

A system and method for functioning organ assessment include a sensing enabled flexible device (102) having an optical fiber configured to sense induced strain continuously over a length of the flexible device. The flexible device includes a manipulation mechanism (105) configured to permit engagement with an interior wall of an organ over the length. An interpretation module(115) is configured to receive optical signals from the optical fiber between two phases of movement of the organ while the organ is functioning and to interpret the optical signals to quantify parameters associated with the functioning of the organ.

SYSTEM AND METHOD FOR NON-INVASIVE INSTANTANEOUS AND CONTINUOUS MEASUREMENT OF CARDIAC CHAMBER VOLUME

A system and method for non-invasive and continuous measurement of cardiac chamber volume and derivative parameters including stroke volume, cardiac output and ejection fraction comprising an ultrawideband radar system having a transmitting and receiving antenna for applying ultrawideband radio signals to a target area of a subject's anatomy wherein the receiving antenna collects and transmits signal returns from the target area which are then delivered to a data processing unit, such as an integrated processor or PDA, having software and hardware used to process the signal returns to produce a value for cardiac stroke volume and changes in cardiac stroke volume supporting multiple diagnostic requirements for emergency response and medical personnel whether located in the battlefield, at a disaster site or at a hospital or other treatment facility.

BLOOD WITHDRAWAL CANNULA OF A PUMP REPLACING OR ASSISTING ACTIVITY OF THE HEART

The invention relates to a blood withdrawal cannula (4) for connecting a pump (2) assisting or replacing activity of the heart to the inner volume of a heart ventricle (1), in particular the left ventricle. At the end thereof that is located in the ventricle the cannula has a pressure sensor (7a, 7b) for measuring the ventricle pressure and/or ventricle pressure differences and at the same end of the cannula has a volume sensor (3a, 3b, 5, 6) for measuring the volume and/or volume changes of the ventricle (1) in at least a partial region of the ventricle. The invention further relates to a measuring device for monitoring the ventricle contractions and/or the function of a pump replacing or assisting activity of the heart. The measuring device can be/is connected to the pressure sensor (7a, 7b) and to the volume sensor of a blood withdrawal cannula according to any one of the preceding claims and is designed to detect pressure changes and volume changes of a ventricle (1) as the heart is ...

SHOCK REDUCTION USING ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION

An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.

METHODS AND APPARATUS FOR ENHANCING CARDIAC PACING

Methods, apparatus and systems for enhancing cardiac pacing generally provide for measuring at least one cardiac characteristic, calculating at least one cardiac performance parameter based on the measured characteristic(s), and adjusting at least one functional parameter of a cardiac pacing device. Devices may include at least one catheter (such as a multiplexed catheter with one or more sensors and/or actuators), at least one implant (such as a sensor implantable in a heart wall), or a combination of both. Various cardiac performance parameters and/or pacing device performance parameters may be weighted, and the parameters and their respective weights may be used to determine one or more adjustments to be made to the pacing device. In some instances, the adjustments are made automatically.

SENSING CATHETER SYSTEM AND METHOD OF FABRICATION

A microminiature sensing module and a sensing catheter system are provided. The module includes a sensor and signal conditioning circuit mounted on a substrate having electrical contacts positioned to facilitate connection of the module to an electrical bus, such as a dual lead electrical bus. The catheter system incorporates a dual lead electrical bus and one or more sensor modules. Methods of fabricating sensing catheter systems are also provided.

CARDIAC OUTPUT ESTIMATION USING PULMONARY ARTERY PRESSURE

A system and method sense a pressure signal in a pulmonary artery and compute a stroke volume and cardiac output. A pressure signal is received from an implantable pressure sensor disposed in a pulmonary artery. The pressure signal includes a systolic period and a diastolic period for determining a heart rate (HR) and a heart cycle. An iteratively-updating model can relate pressure signal and HR to a stroke volume (SV) and a cardiac output (CO). The model extracts a mean pulse pressure (MPP) from the PAP signal and receives a patient-specific vascular resistance model parameter and a patient-specific arterial compliance model parameter. CO can be calculated using the HR, the PAP signal, and the model. The vascular resistance model parameter and the arterial compliance model parameter are iteratively updated using the output of the model.

METHOD FOR DETERMINING HEMODYNAMIC STATE

A method for determining the hemodynamic state of a subject. The method comprises (a) determining the cardiac power index (Cpi) and systemic vascular resistance index (SVRi) values of a plurality of patients who have been diagnosed as having a specified hemodynamic state; (b) determining the range of Cpi and SVRi paired values corresponding to each of the hemodynamic states; (c) determining the Cpi and SVRi paired value of the subject; (d) comparing the Cpi and SVRi paired value of the subject to the ranges of Cpi and SVRi paired values determined in step (b); and (e) determining the range of Cpi and SVRi paired values which is most similar to the Cpi and SVRi paired value of the subject. The hemodynamic state which corresponds to the range indicates the hemodynamic state of the subject.

METHODS OF PRODUCING LASER SPECKLE CONTRAST IMAGES

Methods of imaging are provided. In some embodiments, the methods may comprise obtaining a raw speckle image of a sample, converting the raw speckle image to a laser speckle contrast image using a laser speckle contrast algorithm, and converting a laser speckle contrast image to a relative correlation time image using a relative correlation time algorithm.

METHOD AND APPARATUS FOR TRENDING A PHYSIOLOGICAL CARDIAC PARAMETER

The present invention relates to an implantable cardioverter-defibrillator or pacemaker whose standard circuitry is used to trend a physiological cardiac parameter using intra-cardiac impedance measurements. The trend information may be used to predict the onset of a sudden cardiac death (SCD) event. By being able to predict the onset of an SCD event, patients and their physicians may be forewarned of a life-threatening event allowing them to respond accordingly. The trend information may also be used to predict the efficacy of cardiac-related medications, monitor progress of congestive heart failure, detect the occurrence of myocardial infarction, or simply track changes in sympathetic tone.

System and Method of Extraction, Identification, Marking and Display of Heart Valve Signals

A sensor device and a method using the sensor device includes a portable device (110) configured to capture composite vibration objects from at least one sensor (102b) and further configured to communicate data to a wireless node (105) in some embodiments. The sensor device further includes at least one or more processors (103, 105, or 106) operatively coupled to the portable device and configured to separate and identify separated vibration sources and further configured to identify a plurality of individual heart vibration events (302, 303, 304, 305) from the composite vibration objects where the one or more processors is further configured to mark individual heart events from the plurality of individual heart vibration events. In some embodiments, the one or more processors marks and presents individual heart events from the plurality of individual heart vibration events.

Method for noninvasive continuous determination of physiologic characteristics

The invention comprises methods for noninvasively monitoring physiological characteristics of a patient's blood. Determinations of blood constituent concentrations may be made by comparing absorbance of radiation at varying parameters, such as path length and blood pressure. Preferably, changes in pressure are effected by changing the height of the probes relative to the patient's heart. Determinations of blood pH may be made by comparing absorbance of the blood at different wavelengths. The temperature of the blood, and thus of the patient's core, may also be accurately determined. Further, cardiac output characteristics and blood pressures may be noninvasively determined using the methods of the invention.

Optical coherence tomography device for characterization of atherosclerosis with a 1.7 micron swept laser source

An OCT system with a swept light source centered around 1.7 μm for identifying atherosclerotic plaque and visualization of large lipid pool is provided. Advantages for using the 1.7 μm swept source laser include higher contrast between lipid and normal tissue and deeper penetration of the optical signals from the 1.7 μm swept source laser into the tissue. With deeper penetration into the tissue, more structural information from deep within the tissue is obtained. The present invention also features multimodality imaging systems that integrate additional imaging systems into the OCT system at 1.7 μm. As an example, an integrated 1.3 μm and 1.7 μm OCT system is provided which simultaneously generates OCT images using both the OCT systems which are used to characterize and differentiate the types of tissue.

Device and method for noninvasive continuous determination of physiologic characteristics

The invention comprises devices and methods for the noninvasive monitoring of a physiologic characteristic of a patient's blood, such as blood pressure. One embodiment is a tissue probe combined with a position sensor for determining the relative height of the probe compared to a level corresponding to the patient's heart. Alternatively, the tissue probe can be combined with a movement generator for inducing a height change of the probe with respect to patient's heart. By measuring absorbance characteristics of the blood at varying positions relatively to the level of the patient's heart, characteristics such as arterial and central venous blood pressure and cardiac output can be determined. In yet another embodiment, two probes are used to compute pulse delays between coupled tissues or opposing tissues. Measuring delays in pulse arrival times in coupled organs or members on opposite sides of the body allows the determination of various physiological characteristics.

Hemodynamic reserve monitor and hemodialysis control

Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and/or predict a patient's hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient's dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient's estimated and/or predicted hemodynamic reserve index.

INTERNET-BASED SYSTEM FOR EVALUATING ECG WAVEFORMS TO DETERMINE THE PRESENCE OF P-MITRALE AND P-PULMONALE

The present invention provides an improved, Internet-based system that seamlessly collects cardiovascular data from a patient before, during, and after a procedure for EP or an ID. During an EP procedure, the system collects information describing the patient's response to PES and the ablation process, ECG waveforms and their various features, HR and other vital signs, HR variability, cardiac arrhythmias, patient demographics, and patient outcomes. Once these data are collected, the system stores them on an Internet-accessible computer system that can deploy a collection of user-selected and custom-developed algorithms. Before and after the procedure, the system also integrates with body-worn and/or programmers that interrogate implanted devices to collect similar data while the patient is either ambulatory, or in a clinic associated with the hospital. A data-collection/storage module, featuring database interface, stores physiological and procedural information measured from the patient. 1. A system for determining the presence of p-mitrale and p-pulmonale in a patient's heart , comprising:a database comprising a set of data fields collected from a plurality of patients, with each data field in the set corresponding to an individual patient and including an ECG waveform and a parameter indicating the presence of p-mitrale and p-pulmonale in a patient's heart;an ECG-analysis algorithm configured to process the ECG waveform in each data field to extract a set of parameters, and correlate the set of parameters to the parameter indicating the presence of p-mitrale and p-pulmonale in a patient's heart;an averaging algorithm configured to processes multiple data fields, with each data field corresponding to an individual patient, the averaging algorithm further configured to determine an average correlation factor mapping the set parameters to the parameter indicating the presence of p-mitrale and p-pulmonale in a patient's heart;an ECG-measuring system configured to ...

RAPID QUANTITATIVE EVALUATIONS OF HEART FUNCTION WITH STRAIN MEASUREMENTS FROM MRI

Rapid quantitative evaluations of heart function are carried out with strain measurements from Magnetic Resonance Imaging (MRI) images using a circuit at least partially onboard or in communication with an MRI Scanner and in communication with the at least one display, the circuit including at least one processor that: obtains a plurality of series of MRI images of long and short axis planes of a heart of a patient, with each series of the MRI images is taken over a different single beat of the heart of the patient during an image session that is five minutes or less of active scan time and with the patient in a bore of the MRI Scanner; measures strain of myocardial heart tissue of the heart of the patient based on the plurality of series of MRI images of the heart of the patient; and generates longitudinal and circumferential heart models with a plurality of adjacent compartments, wherein the compartments are color-coded based on the measured strain.

IMAGE PROCESSING AND PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Methods and systems useful in mapping heart rhythm abnormalities

A computer implemented method and system for identifying one or more areas of the heart muscle responsible for supporting or initiating abnormal heart rhythms using electrogram data recorded from a plurality of electrodes obtained from a corresponding series of sensing locations on the heart over a recording time period; the method including the steps of: setting a pre-defined geodesic distance, dividing the recording time period into several analysis time periods, and pairing each sensing location with a plurality of other sensing locations from within the defined geodesic distance, thus forming a plurality of location pairings; for each of the analysis time periods, defining the relative timing of each activation signal for each location within each pairing, determining whether the relative timing of activation signals falls within plausible biological parameters, defining the leading signal of the pair for each electrogram activation within the respective analysis time period; and assigning ...

APPARATUS AND METHOD FOR NON-INVASIVELY MEASURING BLOOD PRESSURE OF MAMMAL SUBJECT

Then the MCU determines the blood pressure P from the PWV, where P is a parabolic function of the PWV.

EFFICIENT AND INTERACTIVE BLEEDING DETECTION IN A SURGICAL SYSTEM

A bleeding detection unit in a surgical system processes information in an acquired scene before that scene is presented on a display unit in the operating room. For example, the bleeding detection unit analyzes the pixel data in the acquired scene and determines whether there are one or more initial sites of blood in the scene. Upon detection of an initial site of blood, the region is identified by an initial site icon in the scene displayed on the display unit. In one aspect, the processing is done in real-time which means that there is no substantial delay in presenting the acquired scene to the surgeon.

SYSTEM AND METHOD FOR OBTAINING BODILY FUNCTION MEASUREMENTS USING A MOBILE DEVICE

Methods, systems, computer-readable media, and apparatuses for obtaining at least one bodily function measurement are presented. A mobile device includes an outer body sized to be portable for user, a processor contained within the outer body, and a plurality of sensors physically coupled to the outer body. The sensors are configured to obtain a first measurement indicative of blood volume and a second measurement indicative of heart electrical activity in response to a user action. A blood pressure measurement is determined based on the first measurement and the second measurement. The sensors also include electrodes where a portion of a user's body positioned between the electrodes completes a circuit and a measurement to provide at least one measure of impedance associated with the user's body. A hydration level measurement is determined based on the measure of impedance.

SYNTHETIC CARDIAC OUTPUT POWER PARAMETER

A method and an apparatus for performing the method are disclosed. The method includes obtaining cardiac output power data on a user; obtaining kinetic data characterizing physical exercise intensity of the physical exercise performed by the user; detecting that a measured cardiac output power exceeds a first threshold or that physical exercise intensity changes according to a rate exceeding a second threshold; upon the detecting, determining a synthetic cardiac output power parameter based at least partly on the kinetic data; and outputting the synthetic cardiac output power parameter.

BIOLOGICAL INFORMATION ANALYSIS DEVICE AND SYSTEM, AND PROGRAM

A biological information analyzing device includes: an indicator extraction unit that obtains data of a blood pressure fluctuation section, which is a section in which a blood pressure fluctuation has occurred, from time series data of a blood pressure waveform measured continuously by a sensor, which is worn on a user's body and can non-invasively measure a blood pressure waveform for each of heartbeats, and extracts an indicator expressing a blood pressure fluctuation type of the user from the data of the blood pressure fluctuation section; and a processing unit that outputs the indicator expressing the blood pressure fluctuation type extracted by the indicator extraction unit.

Device and method for noninvasive continuous determination of physiologic characteristics

The invention comprises devices for noninvasively monitoring physiological characteristics of a patient's blood. Generally, probes having radiation emitters and detectors are used to determine absorbance of blood within the patient's tissue to determine various blood parameters. The device also has either a position sensor for determining the position of the probe with respect to the patient's heart or a movement generator for altering the position of the probe with respect to the patient's heart. The invention also comprises methods for noninvasively monitoring the physiological characteristics. In one embodiemnt, induced positional changes create differential hydrostatic pressures to facilitate measurement of blood parameters by absorbance. In a second embodiment, delays in pulse arrival times in coupled organs or members on opposite sides of the body are measured to determine cardiac output. The two methods are such that they can advantageously be used together.

Biological optical measurement instrument and reference image display method

The biological optical measurement instrument is provided with a mobile position sensor that can move in a 3-dimensional space and that detects spatial position in the 3-dimensional space, a head-surface image creating unit that creates a head-surface image of an object and a head-surface point creating unit that creates, on the head-surface image, a head-surface point corresponding to the spatial position of the mobile position sensor.

TOPOLOGICAL FEATURES AND TIME-BANDWIDTH SIGNATURE OF HEART SIGNALS AS BIOMARKERS TO DETECT DETERIORATION OF A HEART

A system monitors an individual for conditions indicating a possibility of occurrence of irregular heart events. A database includes a plurality of combinations of at least a first signature and a second signature. A first portion of the plurality of combinations is associated with a normal heartbeat and a second portion of the plurality of combinations is associated with an irregular heart event. A wearable heart monitor that is worn on a body of the patient includes a heart sensor for generating a heart signal responsive to monitoring a beating of a heart of the individual. The monitor further includes a processor for receiving the heart signal from the heart sensor. The processor is configured to analyze the heart signal using a plurality of different processes. Each of the plurality of different processes generates at least one of the first signature and the second signature. The plurality of different processes provide a unique combination including at least the first signature and ...

ANALYZER AND METHOD FOR ANALYZING MICROVASCULAR HEMODYNAMIC PARAMETERS

An analyzer and analysis method are provided for analyzing microvascular hemodynamic parameters. The analyzer includes a capillary-pressure detection device, a segmental blood pressure measuring device, a microcirculation microscopic image capturing device, and a data processing and analyzing module. The capillary-pressure detection device is connected to the data processing and analyzing module to measure a capillary pressure and obtain a capillary-pressure signal. The segmental blood pressure measuring device is connected to the data processing and analyzing module to obtain a segmental-blood signal. The microcirculation microscopic image capturing device is connected to the data processing and analyzing module to acquire a static circulation image and a dynamic circulation image. The data processing and analyzing module is used to obtain hemodynamic parameters from each of these signals and images and then plot a Safari blood pressure curve, thereby achieving the acquisition and analysis ...

ECG-BASED CARDIAC EJECTION-FRACTION SCREENING

Systems, methods, devices, and techniques for estimating a heart disease prediction of a mammal. An electrocardiogram (ECG) procedure is performed on a mammal, and a computer system obtains ECG data that describes results of the ECG over a period of time. The system provides a predictive input that is based on the ECG data to a predictive model, such as a neural network or other machine-learning model. In response, the predictive model processes the input to generate an estimated heart disease predictive characteristic of the mammal. The system outputs the estimated heart disease prediction of the mammal for presentation to a user.

Method and apparatus for monitoring of diastolic hemodynamics

A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.

PULSE CONTOUR METHOD AND APPARATUS FOR CONTINUOUS ASSESSMENT OF A CARDIOVASCULAR PARAMETER

METHOD OF EKG SIGNAL PROCESSING AND APPARATUS FOR PERFORMING THE METHOD

SYSTEM AND METHOD FOR IDENTIFYING AUTOREGULATION ZONES

EVENT DETECTION USING A VARIABLE THRESHOLD

Devices and methods for detecting an event using a variable threshold. A patient monitoring system can receive physiologic information and compare the information to an onset threshold. When the onset threshold is exceeded, the system shifts to a reset threshold that is different than the onset threshold. When the reset threshold is crossed, the system shifts back to the onset threshold.

ОЦЕНКА КОЛЛАТЕРАЛЬНОГО КРОВОТОКА

Группа изобретений относится к медицине, а именно к способам и системам анализа коллатерального потока. Способ включает в себя получение показателей первого притока и первой перфузии для нездоровой представляющей интерес ткани, получение показателей второго притока и второй перфузии для здоровой представляющей интерес ткани, и одновременное представление показателей первого потока и перфузии для нездоровой представляющей интерес ткани и показателей второго потока и перфузии для здоровой представляющей интерес ткани. Система включает в себя устройство дополнения данных визуализации, выполненное с возможностью дополнения данных визуализации нездоровой представляющей интерес ткани и здоровой представляющей интерес ткани показателям притока и перфузии для нездоровой и здоровой представляющей интерес ткани. Система также включает в себя определитель оценки, выполненный с возможностью формирования сигнала, указывающего коллатеральную классификационную оценку, на основе показателей притока и перфузии ...

УСТРОЙСТВО ДЛЯ АНАЛИЗА ПУЛЬСОВОЙ ВОЛНЫ И НОСИТЕЛЬ ЗАПИСИ

Изобретение относится к медицине. Способ анализа пульсовой волны выполняют при помощи устройства обработки информации, содержащего запоминающее устройство, блок управления и блок вывода. При этом сохраняют посредством запоминающего устройства пульсовой сигнал для множества сердечных сокращений. Анализируют посредством блока управления пульсовой сигнал для множества сердечных сокращений, чтобы вычислить показатель для анализа пульсовой волны. Показатель для анализа пульсовой волны представляет собой количественную характеристику пульсовых волн объекта измерения. На этапе анализа интегрируют формы пульсовых сигналов от каждого сердечного сокращения, которые составляют пульсовый сигнал для множества сердечных сокращений, чтобы получить интегрированную форму пульсового сигнала, и вычисляют показатель для анализа пульсовой волны после исключения в качестве объекта вычисления сердечного сокращения, для которого степень приближения между интегрированной формой пульсового сигнала и формой пульсового ...

СПОСОБ И СИСТЕМА ДЛЯ ВЫПОЛНЕНИЯ ФОТОПЛЕТИЗМОГРАФИИ

Группа изобретений относится к медицине. Способ фотоплетизмографии содержит этап, на котором обрабатывают сигнал, основанный на по меньшей мере одном сигнале из по меньшей мере одного датчика, выполненного с возможностью захвата света от живого объекта, чтобы выделять информацию о характеристике периодического биологического явления. По меньшей мере, один из сигналов из по меньшей мере одного датчика получают с использованием по меньшей мере одного из источника света и фильтра, установленного перед по меньшей мере одним датчиком, настроенным на максимум в спектре поглощения воды. Группа изобретений позволяет повысить вероятность выделения относительно четкого биометрического сигнала. 2 н. и 8 з.п. ф-лы, 6 ил.

ДОСТОВЕРНЫЙ КЛАССИФИКАТОР

Группа изобретений относится к вычислительной технике и может быть использована для классификации наборов данных. Техническим результатом является обеспечение достоверного анализа и их классификации даже в случае наличия недостающих или неполных данных. Способ содержит этапы, на которых принимают данные, имеющие по меньшей мере один признак из набора признаков, причем принятые данные содержат по меньшей мере один учебный пример, применяют по меньшей мере один обученный низкоразмерный классификатор к принятым данным и присваивают весовые коэффициенты для каждого из упомянутого по меньшей мере одного обученного низкоразмерного классификатора и выводят взвешенную сумму, причем весовые коэффициенты зависят от присутствия или отсутствия входного признака в принятых данных. 3 н. и 12 з.п. ф-лы, 6 ил.

РАСЧЕТ ПЕРФУЗИИ ЦЕНТРАЛЬНОЙ ПОЛОСТИ

Группа изобретений относится к медицинской технике, а именно к системе и способу мониторинга перфузии у пациента. При этом с помощью первого электрода прикладывают напряжение к грудной клетке пациента. Измеряют с помощью второго электрода возникающий вследствие действия приложенного напряжения ток через грудную клетку пациента. Собирают информацию об ударах сердца с помощью подсоединенного ЭКГ. С помощью процессора генерируют волновой сигнал частоты дыхательных движений на основе импеданса, полученного путем деления приложенного напряжения на измеренный ток. Выполняют преобразование Фурье волнового сигнала частоты дыхательных движений относительно ударов сердца пациента. Выделяют артефакты сердечной деятельности из преобразования Фурье. Удаляют несущественные сигналы, возникающие вследствие движения и дыхания пациента. Выполняют обратное преобразование Фурье выделенных артефактов сердечной деятельности для генерирования волнового сигнала, указывающего на объем крови, который закачивается ...

СПОСОБ И АППАРАТ ДЛЯ ПОЛУЧЕНИЯ ДАННЫХ О РАСШИРЕНИИ КРОВЕНОСНЫХ СОСУДОВ, ПРЕДСТАВЛЯЮЩИХ КОЖНУЮ ЛОКАЛЬНУЮ ТЕПЛОВУЮ ГИПЕРЕМИЧЕСКУЮ РЕАКЦИЮ СУБЪЕКТА

Изобретение относится к медицинской технике, а именно к средствам определения параметров расширения кровеносных сосудов. Способ получения значения по меньшей мере одного параметра расширения кровеносных сосудов, представляющего кожную локальную тепловую гиперемическую реакцию тела субъекта, включает выполнение базового измерения в первой области взятия проб субъекта при первой температуре и получение первого базового потока (RBCF) красных кровяных телец области взятия проб и первого базового среднего артериального давления (P) субъекта, повышение температуры первой области взятия проб с первой температуры до второй температуры, поддержание второй температуры для начального периода нагрева, составляющего от 2 до 14 минут, и запись ряда первых начальных RBCF (RBCF) первой области взятия проб при ряде моментов времени (T) для определения первого начального максимального RBCF (RBCF) и запись первого начального среднего артериального давления (P) субъекта во время начального периода нагрева, ...

СПОСОБ ОЦЕНКИ ЦЕРЕБРОВАСКУЛЯРНОЙ РЕАКТИВНОСТИ

Изобретение относится к медицине и может использоваться в неврологии, кардиологии, нейрохирургии и реаниматологии. Измеряют линейную скорость кровотока (ЛСК) в средней мозговой артерии (СМА) в покое и на фоне гиперкапнического нагрузочного теста. При этом в качестве гиперкапнического теста используют ингаляцию 4% смесью двуокиси углерода и воздуха с инжекторной подачей CO2 в течение 2-х минут. Регистрируют изменения линейной скорости кровотока и диаметра средней мозговой артерии. Рассчитывают коэффициент изменения скорости кровотока по формуле: ! где V0 - исходная ЛСК в см/с, V2 - ЛСК через 2 минуты ингаляции в см/с; индекс изменения скорости кровотока по формуле: ! где V0 - исходная ЛСК в см/с, V2 - ЛСК через 2 минуты ингаляции в см/с, Т - время ингаляции в с; коэффициент изменения диаметра по формуле: ! где D0 - исходный диаметр СМА в мм, D2 - диаметр через 2 минуты ингаляции в мм; индекс изменения диаметра по формуле: ! где D0 - исходный диаметр СМА в мм, D2 - диаметр через 2 минуты ...

СПОСОБ ДИАГНОСТИКИ УРОВНЯ АУТОРЕГУЛЯЦИИ СОСУДИСТОГО РУСЛА ВЕРТЕБРОБАЗИЛЯРНОГО БАССЕЙНА ГОЛОВНОГО МОЗГА

Способ относится к медицине, а именно к методам диагностики и функциональной оценки сосудистого русла. Выполняют транскраниальную допплерографию. Производят компрессию плечевых артерий. Затем проводят декомпрессию и сопоставляют время восстановления линейной скорости кровотока до исходного уровня по задней мозговой артерии с его нормой времени. Способ позволяет повысить достоверность диагностики.

Medical image diagnostic apparatus and volume calculating method

A medical image diagnostic apparatus provided with an image acquisition unit configured to acquire in-vivo information about an object to be examined as a medical image, a display unit configured to display the medical image, a setting unit configured to set a target region of volume measurement in the medial image displayed on the display unit, a calculation unit configured to perform calculation to split the target region into a plurality of volume elements, calculate the moving distance of the vertices of the volume elements when the target region of the acquired medical image moves, calculate the volumes of the volume elements after the movement using the calculated moving distance of the vertices, totalizing the calculated volumes of the volume elements after the movement and using the total volume as the volume of the target region, and a control unit configured to display the volume of the target region on the display unit.

Acute ischemia detection based on parameter value range analysis

A heart monitor is disclosed. The monitor computes ST segment deviations and stores the results in heart rate based histograms. Periodically, the monitor analyzes the histogram data to determine a normal range of ST deviation for a particular heart rate range. The monitor computes heart rate dependent ischemia detection thresholds based on the upper and lower boundaries of the normal range.

Method and System For Patient-Specific Modeling of Blood Flow

Embodiments include a system for planning treatment for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of the patient, create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, and determine a first fractional flow reserve within the anatomical structure of the patient based on the three-dimensional model and information regarding a physiological condition of the patient. The at least one computer system may be further configured to receive input from a user regarding a plan of treatment, modify the physiological condition of the patient based on the received input, and determine a second fractional flow reserve within the anatomical structure of the patient based on the modified physiological condition of the patient.

System and method for physiological monitoring

Apparatus, systems, and methods for monitoring a sensor module mounted in a sensor platform, wherein the sensor platform includes an adhesive side and a pocket, wherein the pocket is designed to receive the sensor module, to facilitate sensing by the sensor module of physiological attributes, and to allow insertion and removal of the sensor device from the pocket.

Methods of producing laser speckle contrast images

Methods of imaging are provided. In some embodiments, the methods may comprise obtaining a raw speckle image of a sample, converting the raw speckle image to a laser speckle contrast image using a laser speckle contrast algorithm, and converting a laser speckle contrast image to a relative correlation time image using a relative correlation time algorithm.

Cardiac monitoring system

A method of analysing cardiac functions in a subject using a processing system is described. The method may include applying one or more electrical signals having a plurality of frequencies to the subject and detecting a response to the applied one or more signals from the subject. A characteristic frequency can then be determined from the applied and received signals, and at least one component of the impedance (e.g., reactance, phase shift) can be measured at the characteristic frequency. The impedance or a component of impedance at a characteristic frequency can be determined for a number of sequential time instances. A new characteristic frequency may be determined within a cardiac cycle or the same characteristic frequency may be used throughout the cardiac cycle during which instantaneous values of impedance are determined. These values may be used to determine an indicia of cardiac function.

System for abating neural stimulation side effects

Various system embodiments comprise a neural stimulation delivery system adapted to deliver a neural stimulation signal for use in delivering a neural stimulation therapy, a side effect detector, and a controller. The controller is adapted to control the neural stimulation delivery system, receive a signal indicative of detected side effect, determine whether the detected side enact is attributable to delivered neural stimulation therapy, and automatically titrate the neural stimulation therapy to abate the side effect. In various embodiments, the side effect detector includes a cough detector. In various embodiments, the controller is adapted to independently adjusting at least one stimulation parameter for at least one phase in the biphasic waveform as part of a process to titrate the neural stimulation therapy. Other aspects and embodiments are provided herein.

Aortic pacing to control cardiac afterload

A chronically implanted medical device, connected to a medical electrical lead that includes a sensor, is used to detect cardiac afterload. Electrical stimulation is delivered proximate aortic arch tissue of a patient in order to reduce a patient's cardiac afterload. Electrical stimulation is terminated after a termination condition is met.

Systems and methods for remote monitoring of signals sensed by an implantable medical device during an mri

Systems and methods are provided for allowing an implantable medical device, such as pacemaker, to properly sense electrophysiological signals and hemodynamic signals within a patient during a magnetic resonance imaging (MRI) procedure. Systems and methods are also provided for allowing the implantable medical device to transmit the sensed data to an external monitoring system during the MRI procedure so that attending medical personnel can closely monitor the health of the patient and the operation of the implantable device during the MRI. These improvements provide the attending personnel with information needed to determine whether the MRI should be suspended in response to induced tachyarrhythmias or other adverse conditions within the patient.

Automatic baroreflex modulation responsive to adverse event

A system for providing baroreflex stimulation comprises a sensor to detect a parameter and provide a signal indicative of the parameter and a baroreflex stimulator. The baroreflex stimulator includes a driver to provide a control signal adapted to deliver a baroreflex therapy and a controller to receive the signal indicative of the parameter and modulate the control signal based on the signal indicative of the parameter to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.

Optical sensor and method for detecting a patient condition

An implantable medical device for monitoring tissue perfusion that includes a light source emitting a light signal and a light detector receiving emitted light scattered by a volume of body tissue. The light detector emits a signal having an alternating current component corresponding to the pulsatility of blood flow in the body tissue volume. A processor receives the current signal and determines a patient condition in response to the alternating component of the current signal.

Hemodynamic Reserve Monitor and Hemodialysis Control

Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and/or predict a patient's hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient's dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient's estimated and/or predicted hemodynamic reserve index.

Method and system for patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Method and system for patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Method and device for detecting a critical hemodynamic event of a patient

The invention relates to a method and a device for detecting a critical physiological state of a patient, especially for detecting a critical hemodynamic event. A set of values of physiological parameters is measured, including the heart rate and the pulse arrival time. On the basis of these measurements, a risk assessment is performed including the allocation of a representation of the measured set of values as a vector in a vector space to a risk level representing the risk of the occurrence of a critical hemodynamic event.

SYSTEM AND METHOD FOR EVALUATING AN ELECTROPHYSIOLOGICAL SIGNAL

A method of evaluating an electrophysiological signal is disclosed. A mathematical reconstruction over at least one cycle of the electrophysiological signal is used to identify an abnormal substrate. A non-transitory computer readable medium is also disclosed. The nontransitory computer readable medium has stored thereon instructions for identifying a pathological substrate from a mathematical reconstruction of an electrophysiological signal, which, when executed by a processor, causes the processor to perform steps comprising using a mathematical reconstruction over many cycles of the electrophysiological signal to identify a pathological state. A system for evaluating an electrophysiological signal includes a processor configured to identify a pathological condition from a mathematical reconstruction of the electrophysiological signal. The system also includes a data input coupled to the processor and configured to provide the processor with the electrophysiological signal. The system further includes a user interface coupled to either the processor or the data input. 1. A method of evaluating an electrophysiological signal , comprising:receiving an electrophysiological signal;applying, using a processor of a computing device, a model-derived reconstruction using a summation series of complex exponentials over at least one cycle of the electrophysiological signal to identify a pathological substrate; anddisplaying, on a user interface, one or more indicators of the electrophysiological signal to represent at least a portion of the electrophysiological signal and the pathological condition of the substrate and predict the risk for adverse clinical outcomes2. The method of claim 1 , wherein the complex exponentials of the model-derived reconstruction of the electrophysiological signal comprises an input/output (I/O) expansion of the electrophysiological signal claim 1 , in which at least one of the terms of the I/O expansion are fractionally differentiable and ...

Modeling of pharmaceutical propagation

A method of delivering a contrast enhancing fluid to a patient using an injector system, including: determining at least one patient transfer function for the patient based upon data specific to the patient, the at least one patient transfer function providing a time enhancement output for a given input; determining a desired time enhancement output; using the at least one patient transfer function to determine an injection procedure input; and controlling the injector system at least in part on the basis of the determined injection procedure input.

METHOD AND APPARATUS FOR TRENDING A PHYSIOLOGICAL CARDIAC PARAMETER

The present invention relates to an implantable cardioverter-defibrillator or pacemaker whose standard circuitry is used to trend a physiological cardiac parameter using intra-cardiac impedance measurements. The trend information may be used to predict the onset of a sudden cardiac death (SCD) event. By being able to predict the onset of an SCD event, patients and their physicians may be forewarned of a life-threatening event allowing them to respond accordingly. The trend information may also be used to predict the efficacy of cardiac-related medications, monitor progress of congestive heart failure, detect the occurrence of myocardial infarction, or simply track changes in sympathetic tone. 1. A system for monitoring congestive heart failure , the system comprising:a measuring device configured to measure, using a lead, cardiac impedance of a patient;a derivation module configured to derive a physiologic parameter from the measured impedance;a trending module configured to trend the derived parameter over spaced time intervals to create trended parameter data; and analyze the trended parameter data to determine sympathetic activity; and', 'analyze the sympathetic activity and use the analysis of the sympathetic activity to monitor congestive heart failure status., 'an analyzing module configured to2. The system of claim 1 , wherein the derived parameter includes at least one of stroke volume claim 1 , ejection fraction claim 1 , and pre-ejection period.3. The system of claim 1 , wherein the derived parameter includes stroke volume.4. The system of claim 1 , wherein the derived parameter includes ejection fraction.5. The system of claim 1 , wherein the derived parameter includes pre-ejection period.6. The system of claim 1 , wherein the analyzing module is configured to:analyze the trended parameter data to determine changes in sympathetic activity;analyze the changes in sympathetic activity; anduse the analysis of the changes in sympathetic activity to monitor ...

METHOD AND APPARATUS FOR OBTAINING AND PROCESSING BALLISTOCARDIOGRAPH DATA

A method and apparatus are provided for obtaining and processing ballistocardiograph data to determine a physiological condition of a subject. Ballistocardiograph data indicative of heart motion of the subject measured along a plurality of spatial axes by a sensor device which may comprise a three-axis accelerometer. The ballistocardiograph data is processed to determine processed data indicative of heart motion of the subject. Indications of physiological condition are determined based at least in part on the processed data. Processing may comprise aggregation of multidimensional data, determining magnitude of heart motion and derivative thereof, determining a thrust summation, determining an index value, outputting a report based on an index value, etc. Processing may be informed by operator input, such as a time window of interest or indications of interest. 1. An apparatus for determining information indicative of a subject's physiological condition , said apparatus comprising:a) a sensor device configured to obtain ballistocardiograph data indicative of heart motion of the subject measured along a plurality of spatial axes; andb) a computing device communicatively coupled to the sensor device and configured to receive the ballistocardiograph data therefrom, the computing device configured to determine, based on the ballistocardiograph data, processed data indicative of heart motion of the subject, the computing device further configured to determine one or more indications of the subject's physiological condition based at least in part on the processed data.2. The apparatus according to claim 1 , wherein the sensor device comprises a three-axis accelerometer.3. The apparatus according to claim 2 , wherein the sensor device comprises one or more analog-to-digital converters configured to convert data from the three-axis accelerometer to digital ballistocardiograph data.4. The apparatus according to claim 1 , wherein the ballistocardiograph data comprises time ...

METHOD AND SYSTEM FOR NON-INVASIVELY MONITORING BIOLOGICAL OR BIOCHEMICAL PARAMETERS OF INDIVIDUAL

A system and method are presented for use in monitoring one or more conditions of a subject's body. The system includes a control unit which includes an input port for receiving image data, a memory utility, and a processor utility. The image data is indicative of data measured by a pixel detector array and is in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern. The memory utility stores one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body. The processor utility is configured and operable for processing the image data to determine one or more corresponding body conditions; and generating output data indicative of the corresponding body conditions. 1. A system for use in monitoring one or more conditions of a subject's body , the system comprising a control unit comprising:an input port for receiving image data measured by a pixel detector array and being in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern;a memory utility for storing one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body; and processing the image data and determining a spatial correlation function between successive speckle patterns in the sequence, and determining a time varying spatial correlation function in the form of a time-varying function of at least one feature of the correlation function, the time-varying spatial correlation function being indicative of a change of the speckle pattern over time;', 'selecting at least one parameter of the time-varying spatial correlation function, ...

TECHNIQUES FOR PREDICTION AND MONITORING OF CLINICAL EPISODES

Apparatus and methods are provided including sensing at least one parameter of a subject while the subject sleeps. The parameter is analyzed, and a condition of the subject is determined at least in part responsively to the analysis. The subject is alerted to the condition only after the subject awakes. Other applications are also described. 1175-. (canceled)176. A method comprising:sensing at least one parameter of a subject while the subject sleeps;analyzing the parameter;determining a condition of the subject at least in part responsively to the analysis; andalerting the subject to the condition only after the subject awakes.177. The method according to claim 176 , wherein sensing the at least one parameter comprises sensing the at least one parameter without contacting or viewing the subject or clothes the subject is wearing.178. The method according to claim 176 , wherein the at least one parameter includes at least one motion-related parameter of the subject claim 176 , and wherein sensing the at least one parameter comprises sensing the at least one motion-related parameter without requiring human compliance.179. The method according to claim 176 , wherein sensing the at least one parameter comprises measuring a pressure in claim 176 , on claim 176 , or under a reclining surface upon which the subject lies.180. The method according to claim 176 , wherein determining the condition of the subject comprises predicting an onset of an asthma attack.181. The method according to claim 176 , wherein determining the condition of the subject comprises predicting an onset of an episode associated with the congestive heart failure (CHF) of the subject.182. The method according to claim 176 , wherein determining the condition of the subject comprises predicting an onset of an episode of hypoglycemia caused by diabetes.183. The method according to claim 176 , wherein determining the condition of the subject comprises predicting an onset of an episode selected from the ...

System And Method For Treating Heart Tissue

Some embodiments of a system or method for treating heart tissue can include a control system and catheter device operated in a manner to intermittently occlude a heart vessel for controlled periods of time that provide redistribution of blood flow. In particular embodiments, the system and methods may be configured to monitor at least one input signal detected at a coronary sinus and thereby execute a process for determining a satisfactory time period for the occlusion of the coronary sinus. In further embodiments, after the occlusion of the coronary sinus is released, the control system can be configured to select the duration of the release phase before the starting the next occlusion cycle.

Health monitoring appliance

A heart monitoring system for a person includes one or more wireless nodes forming a wireless network; a wearable body sensor having a wireless transceiver adapted to communicate with the one or more wireless nodes.

AUTOMATED CCHD SCREENING AND DETECTION

Automated critical congenital heart defect (“CCHD”) screening systems and processes are described. A caregiver may be guided to use a single or dual sensor pulse oximeter to obtain pre- and post-ductal blood oxygenation measurements. A delta of the measurements indicates the possible existence or nonexistence of a CCHD. Errors in the measurements are reduced by a configurable measurement confidence threshold based on, for example, a perfusion index. Measurement data may be stored and retrieved from a remote data processing center for repeated screenings. 1. A method of detecting a critical congenital heart defect , the method comprising:instructing a caregiver, using a pulse oximeter display, to measure a pre-ductal blood oxygenation level for a first period of time using the pulse oximeter;instructing the caregiver, using the pulse oximeter display, to measure a post-ductal blood oxygenation level for a second period of time using the pulse oximeter;automatically determining, on the pulse oximeter, a first timeframe within the first period of time, and a second timeframe within the second period of time, during which the measured pre-ductal blood oxygenation level is correlated with the measured post-ductal blood oxygenation level;automatically calculating, on the pulse oximeter, a saturation difference between the measured pre-ductal blood oxygenation level during the first timeframe and the measured post-ductal blood oxygenation level during the second timeframe;automatically detecting, on the pulse oximeter, a critical congenital heart defect based at least in part on the calculated saturation difference; anddisplaying an indication of the critical congenital heart defect on the display of the pulse oximeter.2. The method of claim 1 , wherein the calculated saturation difference comprises an average of the difference over the first timeframe and the second timeframe.3. The method of claim 1 , wherein the first period of time and the second period of time are ...

METHOD AND APPARATUS FOR CHARACTERIZATION OF CLOT FORMATION

Methods, apparatus and systems for characterizing changes in at least one physical property of soft tissue. A series of acoustic pulses is generated and directed into the soft tissue such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the tissue. Waves reflected off the tissue, or a flexible member that moves with the tissue, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. Repetition of the generating, receiving and estimating steps provides characterization of the at least one physical property over time. Methods, apparatus and systems for characterizing at least one physical property of blood, by generating a series of acoustic pulses and directing the series of pulses into the blood such that at least one of the pulses is of sufficiently high intensity to induce physical displacement of the blood. Acoustic pulses and/or optical waves reflected from the blood, or a flexible member in contact with the blood that moves with the blood, are received and measured to estimate at least one characteristic of the physical displacement induced thereby. 1. A method of characterizing at least one property of a biological material , said method comprising:testing a first portion of the biological material;estimating a quantitative value of a property of the first portion;treating a second portion of the biological material with a treatment to vary a quantitative value of said property from said quantitative value of the property of the first portion having been estimated;testing the second portion of the biological material having been treated;estimating a second quantitative value of said property of the second portion;comparing said first quantitative value with said second quantitative value; andevaluating an effect of said treating on said property of the biological material.2. The method of claim 1 , wherein said testing a first portion of the biological ...

APPARATUS FOR EVALUATING A PATIENT'S HEMODYNAMIC STATUS USING A HEART-LUNG INTERACTION

Apparatus for evaluating a mechanically ventilated patient's hemodynamic status, adapted to provide a respiratory variation diagram of a hemodynamic variable, and being capable of deriving the value of a hemodynamic parameter for each mechanical breath cycle as well as an assessment of its suitability for the hemodynamic analysis on basis of the respiratory variation diagram. A method is also provided. 1. An apparatus for evaluating a hemodynamic status of a mechanically ventilated patient , comprising:a device adapted to analyze a respiratory variation of a hemodynamic variable, and being capable of deriving a value of a hemodynamic parameter for each mechanical breath cycle as well as an assessment of a suitability of the value of the hemodynamic parameter for a hemodynamic analysis on the basis of a respiratory variation diagram.2. The apparatus according to claim 1 , wherein the hemodynamic variable is an arterial pulse pressure (PP) and the hemodynamic parameter is an arterial pulse pressure variation (PPV).3. The apparatus according to claim 2 , further comprising an arterial catheter for measuring the arterial pulse pressure (PP).5. The apparatus according to claim 1 , wherein the hemodynamic variable is the arterial systolic pressure and the hemodynamic parameter is the arterial systolic pressure variation.6. The apparatus according to claim 5 , further comprising an arterial catheter for measuring the arterial systolic pressure.7. The apparatus according to wherein the hemodynamic variable is the left ventricular stroke volume and the hemodynamic parameter is the left ventricular stroke volume variation.8. The apparatus according to claim 7 , further comprising a sensor allowing the beat by beat measurement of the left ventricular stroke volume.9. The apparatus according to wherein the hemodynamic variable is the pulse oximetry plethysmographic waveform and the hemodynamic parameter is the pulse oximetry plethysmographic waveform variation.10. The apparatus ...

SYSTEM AND METHODS FOR ASSESSING HEART FUNCTION

Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points. 1. A method for assessing a function of a patient's heart , comprising:determining a time-based electrical characteristic for a plurality of points corresponding to at least one spatial region of the heart;grouping the plurality of points into at least two subsets of points based on at least one of a spatial location for each of the plurality of points or the time-based electrical characteristic for each of the plurality of points; andquantifying an indication of synchrony for the heart based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.2. The method of claim 1 , wherein the at least two subsets of points correspond to different chambers of the heart claim 1 , the method further comprising computing an index having at least one value representing synchrony between the different chambers.3. The method of claim 2 , wherein the different chambers of the heart comprise the left ventricle and the right ventricle.4. The method of claim 2 , wherein the quantifying further comprises:computing a first statistical parameter for each of the plurality of points associated with a first chamber of the heart,computing a second ...

Devices, systems and methods for efficient identification of improved crt parameters

Methods, systems and devices efficiently identify cardiac resynchronization therapy (CRT) pacing parameter set(s) that provide improved hemodynamic response relative to an initial CRT pacing parameter set, wherein each CRT pacing parameter set includes at least two CRT pacing parameters. User input(s) are accepted that specify a maximum amount of time and/or parameter sets that can be used to perform testing, and specify relative importance of parameters within the sets. Based on the accepted user input(s), there is a determination of how many different variations of each of the CRT pacing parameters can be tested, and based on this determination different CRT pacing parameter sets are selected and tested to obtain a hemodynamic response measure corresponding to each of the different sets tested. Additionally, one or more of the tested CRT pacing parameter sets, if any, that provide improved hemodynamic response relative to the initial CRT pacing parameter set is/are identified.

System and method for deep vein thrombosis prevention and diagnosis

A system and method prevents and diagnoses deep vein thrombosis in a body limb by providing a pressure sleeve having a plurality of individually fillable cells, the pressure sleeve being configurable to be placed around a body limb. A source fills each fillable cell individually, and a pressure sensor measures a pressure in a fillable cell. A controller establishes a fill sequence of each individually fillable cell and a fill time for each individually fillable cell. The controller causes a first individually fillable cell of the pressure sleeve to be filled to a predetermined pressure and causes the pressure of first individually fillable cell of the pressure sleeve to be measured while a second individually fillable cell of the pressure sleeve is filled. The controller determines a presence of deep vein thrombosis in a body limb having the pressure sleeve therearound based upon a measured pressure change in the first individually fillable cell of the pressure sleeve.

Method and system for optimizing cardiac pacing settings

The present invention relates generally to methods and systems for optimizing stimulation of a heart of a patient. Hemodynamical index signals reflecting a mechanical functioning of a heart of a patient are recorded at different hemodynamical states. Corresponding hemodynamical reference signals at corresponding hemodynamical states are recorded. At least one hemodynamical index parameter is extracted from the recorded hemodynamical index signals. The at least one hemodynamical index parameter is a measure of the mechanical functioning of the heart and a hemodynamical index model is created, wherein the hemodynamical index model is based on the at least one hemodynamical index parameter and a comparison between output results from the hemodynamical index model and corresponding hemodynamical reference signals. From this hemodynamical index model, a hemodynamical index can be derived, which then can be used in determining patient customized cardiac pacing settings of the cardiac stimulator.

SYSTEM AND METHODS FOR MANAGING BLOOD LOSS OF A PATIENT

One variation of the method for managing blood loss of a patient includes: receiving an image of a physical sample; extracting a feature from an area of the image corresponding to the physical sample; estimating a blood volume indicator of the physical sample according to the extracted feature; estimating a patient blood loss based on the blood volume indicator; estimating a euvolemic patient hematocrit based on an estimated patient blood volume and the estimated patient blood loss; receiving a measured patient hematocrit; and generating a volemic status indicator based on a comparison between the measured patient hematocrit and the estimated euvolemic patient hematocrit. 1. A method for managing blood loss of a patient , comprising:receiving an image of a physical sample;extracting a feature from an area of the image corresponding to the physical sample;estimating a blood volume indicator of the physical sample according to the extracted feature;estimating a patient blood loss based on the blood volume indicator;estimating a euvolemic patient hematocrit based on an estimated patient blood volume and the estimated patient blood loss;receiving a measured patient hematocrit; andgenerating a volemic status indicator based on a comparison between the measured patient hematocrit and the estimated euvolemic patient hematocrit.2. The method of claim 1 , further comprising tracking a quantity of a fluid administered to the patient intravenously and estimating an intracirculatory patient hematocrit based on a previous patient hematocrit claim 1 , the estimated patient blood loss claim 1 , a quantity of a fluid administered to the patient claim 1 , and the estimated patient blood volume.3. The method of claim 2 , further comprising extrapolating a volume of insensible patient fluid loss from a difference between the estimated intracirculatory patient hematocrit and the measured patient hematocrit.4. The method of claim 2 , further comprising estimating an effectiveness of the ...

ESTIMATION OF SYSTEMIC VASCULAR RESISTANCE AND CARDIAC OUTPUT USING ARTERIAL PULSE OXIMETRY WAVEFORMS

The invention relates to a method to estimate sytemic vascular resistance (SVR) and cardiac output (CO) from a pulse oximeter (photoplethysmography, PTG), comprising the steps of generating arterial blood pulse wave forms having first and second peaks, generating a Fast Fourier Transform and calculating the ratio of the height of the second peak (B) to the first peak (A) across the entire measurement using the equation FFTRI to estimate SVR, and the equation CO=(SR/FFTRI)×80 to estimate CO, where SR=S2/S1 and wherein SI and S2 are the areas under the whole PTG wave and the part in diastolic phase, respectively. 2. A method to estimate Cardiac Output (CO) from a wave form generated over time by a pulse oximeter using the equation{'br': None, 'i': CO=', 'SR/, '(FFTRI)×80'}{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'wherein FFTRI is as calculated in and'}SR=S2/S1 wherein SI and S2 are the areas under the whole PTG wave and the part of wave in diastolic phase.3. A method as claimed in wherein the time period of generation of the waveform is between 1 and 3 minutes.4. Use of a pulse oximeter capable of generating arterial blood waveform in a method as claimed in .5. Use of a pulse oximeter as claimed in in combination with means to remotely send waveform information for CO analysis to a physician.6. An apparatus to estimate cardiac output average during 2 minute time using an oximeter which can provide heart rate detection and arterial blood wave form for use in the method as set out in to estimate and/or monitor CO. The present application relates to an apparatus and method to measure cardiac output. More specifically the invention relates to a method of measuring cardiac output using a pulse oximeter and use of a pulse oximeter to measure cardiac output.Cardiovascular disease (CVD) is the number one cause of death globally and is projected to remain the leading cause of death (WHO, 2008). An estimated 17.5 million people died from cardiovascular disease in 2005, ...

SYSTEM AND METHOD FOR NON-INVASIVE INSTANTANEOUS AND CONTINUOUS MEASUREMENT OF CARDIAC CHAMBER VOLUME

A system and method for non-invasive and continuous measurement of cardiac chamber volume and derivative parameters including stroke volume, cardiac output and ejection fraction comprising an ultrawideband radar system having a trans-mitting and receiving antenna for applying ultrawideband radio signals to a target area of a subject's anatomy wherein the receiving antenna collects and transmits signal returns from the target area which are then delivered to a data processing unit, such as an integrated processor or PDA, having software and hardware used to process the signal returns to produce a value for cardiac stroke volume and changes in cardiac stroke volume supporting multiple diagnostic requirements for emergency response and medical personnel whether located in the battlefield, at a disaster site or at a hospital or other treatment facility. 1. A medical device for determining a change in the spatial configuration of a heart , comprising: at least one antenna adapted to be located adjacent a portion of the heart; and a sensing unit capable of resolving a change in reflected signals , wherein said sensing unit of the medical device is capable of resolving a change in reflected signals that are functionally related to a change in cardiac ventricular volume.2. A medical device according to wherein the device is located external to the body.3. A medical device claim 1 , according to claim 1 , wherein said sensing unit further comprises: a substrate and a plurality of antennae mounted to said substrate in a pattern and being capable of both transmitting and receiving radiofrequency signals.4. A medical device according to claim 1 , wherein the reflected signals are derivative of an earlier transmitted ultrawideband signal.5. A medical device according to claim 1 , wherein the reflected signals are derivative of an earlier transmitted ultrawideband signal having a frequency band extending from 1 GHz to 15 GHz.6. A medical device according to claim 1 , wherein the ...

POSTURE-INDUCED CHANGES TO PHYSIOLOGICAL PARAMETERS

Methods and devices for analyzing posture-induced changes to physiological parameters of a patient (e.g., ejection time, heart rate, etc.) to provide an assessment of one or more conditions of the patient. 122-. (canceled)23. An implantable medical device for use in assessment of one or more conditions of a patient comprising:sensing apparatus to monitor physiological parameters of the patient, wherein the physiological parameters comprise the patient's ejection time, wherein the patient's ejection time comprises at least one of the patient's left ventricular ejection time and right ventricular ejection time; and ["determine a posture-induced change to the patient's ejection time based on the patient's ejection time before a change in the patient's posture and the patient's ejection time after the change in the patient's posture, and", "assess one or more conditions of the patient based on the posture-induced change to the patient's ejection time."], 'a control module configured to24. The device of claim 23 , wherein the one or more conditions of the patient comprise fluid overload.25. The device of claim 23 , wherein the posture-induced change to the patient's ejection time further comprises a difference between the patient's average ejection time over a first predetermined period of time before the detected change in the patient's posture and the patient's average ejection time over a second predetermined period of time after the detected change in the patient's posture.26. The device of claim 23 , wherein the control module is configured to analyze the posture-induced change to the patient's ejection time by comparing the posture-induced change to the patient's ejection time to a baseline value.27. The device of claim 23 , wherein the analysis of the posture-induced change to the patient's ejection time provides an assessment that indicates that the patient is afflicted with fluid overload if the posture-induced change to the patient's ejection time is less than ...

Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines

The present invention is directed to an integrated system and a method for utilizing the system to detect and remove blood-borne factors of interest, such as pathogens and/or toxins and/or cytokines, from blood or serum (blood) by contacting the blood with a solid, essentially nonporous substrate which has been surface treated with molecules or chemical groups (the adsorbent media or media) having a binding affinity for the pathogens and/or toxins to be removed (the adsorbents). The invention can be used to remove virulence factors, e.g. toxins, that are released from various pathogens. In one aspect, the invention is for the treatment of sepsis and infection, such as infections associated with battle field trauma.

Prediction and monitoring of clinical episodes

Apparatus and methods are provided including sensing at least one parameter of a subject while the subject sleeps. The parameter is analyzed, and a condition of the subject is determined at least in part responsively to the analysis. The subject is alerted to the condition only after the subject awakes. Other applications are also described.

PERFUSION DETECTION SYSTEM

According to some embodiments, a system for detecting a perfusion index of a cardiac pulse includes a first sensor that senses a first physiological or environmental parameter of a human patient core, a second sensor that senses a second physiological or environmental parameter of the human patient core, a processor that, responsive to the first and second sensed parameters, determines a perfusion index ranging from 0 to 10 that reflects inadequate, marginal, or adequate blood perfusion to the core of the human patient torso, and an indicator that provides a discernible indication of the perfusion index. A method of detecting as perfusion index of a cardiac pulse responsive to sensing first and second physiological or environmental parameters of a human patient core is also disclosed. 1. A system for detecting a perfusion index of a cardiac Pulse Comprising:a first sensor that senses a first physiological or environmental parameter of a human patient corea second sensor that senses a second physiological or environmental parameter of the human patient core;a processor that, responsive to the first and second sensed parameters, determines a perfusion index ranging from 0 to 10 that reflects inadequate, marginal, or adequate blood perfusion to the core of the human patient torso; andan indicator that provides a discernible indication of the perfusion index.212. The system of claim 1 , wherein the first and second sensors include at least one of an accelerometer/force sensor claim 1 , photoplethsmography sensor claim 1 , an ECG sensor claim 1 , one or more leads claim 1 , a one to three axis accelerometer/force sensor claim 1 , and an S/S heart sound sensor.3. The system of claim 1 , further including a cardiac arrest detector.4. The system of claim 1 , further including a detector that detects the existence of PEA (Pulseless electrical activity).5. The system of claim 1 , wherein the processor is programmable to determine the presence of atrial fibrillation for those ...

Apparatus and method for detecting myocardial ischemia using analysis of high frequency components of an electrocardiogram

ECG apparatus comprises an ECG input for obtaining ECG signals; a high frequency analyzer configured for obtaining high frequency QRS components from a QRS complex within said ECG signals and identifying therein at least one reduced amplitude zone—RAZ—present within a given QRS complex; and a RAZ quantifier configured for obtaining a quantification of said at least one RAZ region within said QRS complex.

WIRELESS STETHOSCOPE AND METHOD OF USE THEREOF

A wireless stethoscope is described, having wireless sensors that are enclosed in disposable pads so that the same pads are not used on more than one patient, preventing cross-infection of patients associated with conventional stethoscopes. The present wireless stethoscope also detects pulmonary sounds and cardiac sounds, allowing the user to monitor one or the other without interference. Also described is a method for diagnosing a pulmonary condition using the wireless stethoscope. 1. A wireless stethoscope comprising at least one wireless sensor for monitoring at least one bodily sound and a receiver unit , wherein said wireless sensor detects one or more bodily sounds , converts said one or more bodily sounds into sound signals , and transmits said sound signals wirelessly to said receiver unit , wherein said receiver receives and processes said sound signals and transmits said sound signals to a user-end listening and displaying device.2. The wireless stethoscope of claim 1 , wherein said wireless sensor is enclosed in or attaches to a disposable pad.3. The wireless stethoscope of claim 1 , wherein said wireless sensor comprises at least one microphone that detects bodily sounds.4. The wireless stethoscope of claim 1 , wherein said wireless stethoscope comprises more than one wireless sensor programmed to said receiver unit.5. The wireless stethoscope of claim 1 , wherein said wireless sensor comprises a rechargeable battery.6. The wireless stethoscope of claim 1 , wherein said bodily sound is selected from the group consisting of a pulmonary sound claim 1 , a cardiac sound claim 1 , and a digestive sound.7. The wireless stethoscope of claim 1 , wherein said receiver unit is an electronic device selected from the group consisting of a cell phone claim 1 , smart phone claim 1 , PDA and tablet computer.8. The wireless stethoscope of claim 7 , wherein said electronic device comprises an application for monitoring said at least one bodily sound.9. The wireless ...

Device and method for the geometric determination of electrical dipole densities on the cardiac wall

Disclosed are devices, a systems, and methods for determining the dipole densities on heart walls. In particular, a triangularization of the heart wall is performed in which the dipole density of each of multiple regions correlate to the potential measured at various locations within the associated chamber of the heart.

EFFICIENT AND INTERACTIVE BLEEDING DETECTION IN A SURGICAL SYSTEM

A bleeding detection unit in a surgical system processes information in an acquired scene before that scene is presented on a display unit in the operating room. For example, the bleeding detection unit analyzes the pixel data in the acquired scene and determines whether there are one or more initial sites of blood in the scene. Upon detection of an initial site of blood, the region is identified by an initial site icon in the scene displayed on the display unit. In one aspect, the processing is done in real-time which means that there is no substantial delay in presenting the acquired scene to the surgeon. 1. A method comprising: wherein the frame includes a plurality of locations, and', 'wherein each location includes pixels for a plurality of color components;, 'receiving, by a system, a frame including a scene of a surgical site,'}detecting, by the system, whether the plurality of color component pixels of each location includes information indicative of blood at that location;determining, by the system, a region of blood in the scene based on locations detected as including information indicative of blood; andidentifying, by the system, the region of blood with an initial site icon when the region of blood is an initial region of blood, wherein the initial site icon identifies an initial position of blood in the scene.2. The method of claim 1 , where the identifying further comprises:combining, by the system, the initial site icon with the scene to obtain a combined image.3. The method of claim 2 , further comprising:displaying the combined image on a display unit.4. The method of claim 3 , further comprising:determining whether to perform the displaying based on a user input.5. The method of claim 3 , further comprising:determining whether to perform the displaying based on information of a surgical system.6. The method of claim 1 , wherein the initial site icon comprises an arrow.7. The method of claim 1 , further comprising:identifying the region of blood ...

Thorascopic Heart Valve Repair Method and Apparatus

An instrument for performing thorascopic repair of heart valves includes a shaft for extending through the chest cavity and into a heart chamber providing access to a valve needing repair. A movable tip on the shaft is operable to capture a valve leaflet and a needle is operable to penetrate a capture valve leaflet and draw the suture therethrough. The suture is thus fastened to the valve leaflet and the instrument is withdrawn from the heart chamber transporting the suture outside the heart chamber. The suture is anchored to the heart wall with proper tension as determined by observing valve operation with an ultrasonic imaging system. 117-. (canceled)18. A method of capturing a moving heart valve leaflet in a beating heart of a patient , comprising:inserting an instrument through a patient's chest wall and into a patient's chest cavity through a minimally invasive opening;inserting a distal end of the instrument through a heart wall and into a beating heart of the patient;grasping the moving valve leaflet of a heart valve in the beating heart with the distal end of the instrument;confirming at a proximal end of the instrument external to the patient capture and proper positioning of the moving valve leaflet relative to the instrument with a fiber optic capture confirmation system having a plurality of illumination fiber optics and detection fiber optics that detect light from the illumination fiber optics reflected off of the leaflet when the leaflet is properly positioned relative to the instrument, the capture confirmation system providing a plurality of independent indications of the positioning of the leaflet relative to the instrument.19. The method of claim 19 , wherein the instrument includes a shaft having a distal end and a movable element longitudinally displaceable relative to the shaft claim 19 , and wherein grasping a moving valve leaflet with the instrument includes capturing the leaflet between the movable element and the distal end of the shaft.20. ...

DEVICE FOR THE ANALYSIS OF AN ENDOCARDIAC SIGNAL OF ACCELERATION

Devices and methods related to endocardial acceleration signal processing are provided. One device is configured to: (1) divide an endocardial acceleration (EA) signal into a plurality of EA sub-signals; (2) identify, in each of the plurality of EA sub-signals, at least one signal component associated with a type of heart sound; (3) extract a characteristic of the at least one signal component for two or more of the plurality of cycles; (4) calculate a correlation coefficient correlating the at least signal component for a first cycle of the plurality of cycles to the at least one signal component of a second cycle of the plurality of cycles; and (5) perform temporal retiming of one or more of the signal components based on the correlation coefficient to generate one or more adjusted signal components of the associated one or more EA sub-signals. 1. An implantable medical device comprising:a processor;an endocardial acceleration sensor; and divide an endocardial acceleration (EA) signal into a plurality of EA sub-signals, wherein the EA signal is collected over a plurality of cardiac cycles using the endocardial acceleration sensor, and wherein each of the plurality of EA sub-signals corresponds to a single cardiac cycle of the plurality of cardiac cycles;', 'identify, in each of the plurality of EA sub-signals, at least one signal component associated with a type of heart sound, wherein each signal component is associated with the cardiac cycle of its EA sub-signal;', 'extract a characteristic of the at least one signal component for two or more of the plurality of cycles;', 'calculate a correlation coefficient correlating the at least signal component for a first cycle of the plurality of cycles to the at least one signal component of a second cycle of the plurality of cycles; and', 'perform temporal retiming of one or more of the signal components based on the correlation coefficient to generate one or more adjusted signal components of the associated one or more ...

Monitoring volaemic condition in a human or animal subject

A method for processing data to monitor volaemic condition in a human or animal subject includes identifying one or more reference values for each of one or more haemodynamic variables; receiving haemodynamic data representing the one or more haemodynamic variables measured from the subject over time; for at least one of the one or more haemodynamic variables, comparing the haemodynamic data with the respective one or more reference values; and identifying the existence of abnormal volaemic condition in the subject when the comparison indicates a deviation from the one or more reference values for at least one of the haemodynamic variables. The method may be combined with a visual display of haemodynamic data in real time, ideally in conjunction with a visual indicator of ideal reference values.

SYSTEMS AND METHODS FOR DETECTING ISCHEMIC EVENTS

Embodiments of the present invention relate to implantable systems, and method for use therein, that can detect myocardial ischemic events. In accordance with specific embodiments of the present invention, short-term fluctuations in cardiac intervals that follow premature ventricular contractions (PVCs) are monitored. This allows myocardial ischemic events to be detected based on these monitored fluctuations. The cardiac intervals for which fluctuations are being monitored can be, for example, RR intervals. Alternatively, or additionally, short-term fluctuations in other types of cardiac intervals may be monitored. Such other cardiac intervals include, for example, PR intervals, PP intervals, QT intervals and RT intervals. 1. An implantable system , comprising:a monitor that monitors short-term fluctuations in cardiac intervals that follow premature ventricular contractions;a detector that detects ischemic events based on the monitored fluctuations, determines whether a patient is experiencing an ischemic event, and, when the patient is experiencing an ischemic event, at least one of the following: triggers myocardial ischemia therapy, transmits an alert that an action appropriate to the detection of myocardial ischemia should be taken, and stores a measure of myocardial ischemia burden.2. The system of claim 1 , wherein the monitor monitors cardiac intervals that both precede and follow each premature ventricular contraction claim 1 , such that cardiac intervals that precede the premature ventricular contraction can be used in calculating the short-term fluctuations in cardiac intervals that follow the premature ventricular contraction.3. The system of claim 1 , wherein the monitor monitors short-term fluctuations in cardiac intervals within beats that follow a premature ventricular contraction.4. The system of claim 1 , wherein the premature ventricular contractions are intrinsic claim 1 , induced or simulated claim 1 , or combinations thereof.5. The system of ...

SYSTEMS AND METHODS FOR NETWORKED WEARABLE MEDICAL SENSORS

A medical sensor system comprises a gateway comprising a wideband receiver and a narrow band transmitter, the each gateway configured to receive a wideband positioning frame using the wideband receiver from one or more wearable sensors and to transmit acknowledgement frames using the narrow band transmitter that include timing and control data for use by the sensors to establish timing for transmission of the positioning frame; and at least one wearable sensor comprising a wideband transmitter and a narrow band receiver, the sensor configured to transmit a sensor data frame to the gateway using the wideband transmitter and to receive an acknowledgement frame from the gateway using the narrow band receiver, extract timing and control information from the frame, and adjust the timing and synchronization of the wideband transmitter using the timing and control information. 1a gateway comprising a wideband receiver and a narrow band transmitter, the each gateway configured to receive a wideband positioning frame using the wideband receiver from one or more wearable sensors and to transmit acknowledgement frames using the narrow band transmitter that include timing and control data for use by the sensors to establish timing for transmission of the positioning frame; andat least one wearable sensor comprising a wideband transmitter and a narrow band receiver, the sensor configured to transmit a sensor data frame to the gateway using the wideband transmitter and to receive an acknowledgement frame from the gateway using the narrow band receiver, extract timing and control information from the frame, and adjust the timing and synchronization of the wideband transmitter using the timing and control information.. A medical sensor system comprising: 1. Technical FieldThe embodiments described herein are related to wireless communication and in particular to systems and methods for medical sensors that can sense a plurality of vital signs and that can provide imaging within the ...

PROVISION OF ATYPICAL BRAIN ACTIVITY ALERTS

Computer-implemented techniques are disclosed for analyzing physiology data captured by biosensors and for providing alerts based on the biosensor data. The biosensor data is captured non-invasively and is analyzed to identify atypical brain activity that can result from illness, injury, disease, and seizures. The biosensor data can include electrodermal activity, skin temperature, and accelerometer data. The data is sent to a web service for analysis, and to determine whether an alert should be generated. The alerts, based on the biosensor data captured from the individual, are received from the web service. An output related to physiology is rendered based on an alert being received from the web service. 1. A computer-implemented method for physiology analysis comprising:capturing biosensor data from a person;sending the biosensor data to a mobile device;providing the biosensor data to a cloud-computing environment;processing the biosensor data to identify atypical brain activity; andproviding an alert based on the atypical brain activity that was detected.2. The method of wherein the biosensor data includes one or more of electrodermal activity claim 1 , accelerometer data claim 1 , and skin temperature.3. The method of wherein the processing is performed in the cloud-computing environment.4. The method of wherein the mobile device is incorporated as part of a biosensor.5. The method of wherein the atypical brain activity comprises a SUDEP risk claim 1 , an epileptiform seizure claim 1 , a drug reaction claim 1 , stress claim 1 , depression claim 1 , compulsive behavior claim 1 , ictal brain activity claim 1 , inter-ictal brain activity claim 1 , a tonic-clonic seizure claim 1 , a partial complex seizure claim 1 , pain claim 1 , anxiety claim 1 , a panic attack claim 1 , an epileptic seizure claim 1 , a sleep disorder claim 1 , a respiratory sleep problem claim 1 , an heart attack claim 1 , a reaction to medication claim 1 , a bipolar attack claim 1 , distracted ...

ASSESSMENT OF CORONARY HEART DISEASE WITH CARBON DIOXIDE

The invention provides methods for diagnosing coronary heart disease in a subject in need thereof comprising administering an admixture comprising CO2 to a subject to reach a predetermined PaCO2 in the subject to induce hyperemia, monitoring vascular reactivity in the subject and diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease. The invention also provides methods for increasing sensitivity and specificity of BOLD MRI. 1. A method for diagnosing coronary heart disease in a subject in need thereof comprising:{'sub': 2', '2, '(i) administering an admixture comprising COto a subject to reach a predetermined PaCOin the subject to induce hyperemia;'}(ii) monitoring vascular reactivity in the subject; and(iii) diagnosing the presence or absence of coronary heart disease in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of coronary heart disease,thereby diagnosing coronary heart disease in the subject in need thereof.2. A method for assessing hyperemic response in a subject in need thereof comprising:{'sub': 2', '2, '(i) administering an admixture comprising COto a subject to reach a predetermined PaCOin the subject to induce hyperemia;'}(ii) monitoring vascular reactivity in the subject; and(iii) assessing hyperemic response in the subject, wherein decreased vascular reactivity in the subject compared to a control subject is indicative of poor hyperemic response,thereby assessing hyperemic response in the subject in need thereof.3. A method of producing coronary vasodilation in a subject in need thereof comprising:{'sub': '2', '(i) providing a composition comprising CO; and'}{'sub': 2', '2, '(ii) administering an admixture comprising COto the subject to reach a predetermined PaCOin the subject, so as to produce coronary vasodilation.'}4. A method for assessing ...

Method for Determining non-invasively a Heart-Lung Interaction

The present disclosure concerns a method for determining a heart-lung interaction factor of a subject, comprising: measuring a heart activity-related signal comprising heart activity-related information; from the heart activity-related signal, calculating a frequency of cardiac cycle and a frequency of respiratory cycle; from the heart activity-related signal, determining a cardiac cycle energy at the frequency of cardiac cycle, determining a respiratory cycle energy at the frequency of respiratory cycle, and determining a heart-lung interaction energy at an intermodulation frequency corresponding to the difference between the frequency of respiratory cycle and the frequency of cardiac cycle, or the sum of the frequency of respiratory cycle and the frequency of cardiac cycle; and determining a heart-lung interaction factor from the ratio of the heart-lung interaction energy and one of the cardiac cycle energy and the respiratory cycle energy. The heart-lung interaction factor can be determined non-invasively.

OPTICAL COHERENCE TOMOGRAPHY AND PRESSURE BASED SYSTEMS AND METHODS

In part, the invention relates to methods, apparatus, and systems suitable for determining a fractional flow reserve (FFR) and variations of modifications thereof One embodiment relates to a method and apparatus for obtaining a corrected FFR in a vessel having a stenosis. In one aspect, the invention relates to an apparatus for measuring corrected FFR of a vessel having a stenosis. In one embodiment, the apparatus includes a probe comprising an optical coherence tomography assembly and a pressure assembly; and a processor in communication with the optical coherence tomography assembly and the pressure assembly. In one embodiment, the pressure assembly measures values of pressure in predetermined locations the vessel and communicates them to the processor. In one embodiment, a dual guidewire is used to reduce the interference in the pressure measurement. 1. A data collection system comprising:a pressure assembly configured to measure pressure at one or more predetermined locations in a vessel, andan optical coherence tomography assembly configured to measure a geometry of the vessel at one or more of the predetermined locations within the vessel.2. The system of further comprising a probe claim 1 , wherein the optical coherence tomography assembly is disposed in the probe.3. The system of wherein the optical coherence tomography assembly comprises an optical fiber claim 2 , wherein the probe further comprisesa first torque wire having a first diameter and defining a first lumen anda second torque wire having a second diameter and defining a second lumen,wherein the first and second torque wires are joined, andwherein the optical fiber passes through the first lumen and the second lumen.4. The system of further comprising a probe claim 1 , wherein the optical coherence tomography assembly is disposed in the probe claim 1 , the optical coherence tomography assembly comprisesan optical fiber configured to transmit light of a first wavelength band and a second wavelength ...

Method and Apparatus for Full-System, Cardiovascular Simulation and Prediction

A system and method for real-time, a closed-loop, complete body hemodynamic simulation of a patient undergoing a surgical procedure is disclosed. A simplified model of blood circulation that is nevertheless comprehensive and derives input representative of the patient's entire circulatory system, is mathematically modeled by a combination of 1-D mathematical models, and lumped parameter models. The system allows a clinician to select an intended intervention that is then computationally simulated in real, or quasi-real, time. The results of the simulation are presented as a heartbeat by heartbeat simulation of clinician selected, relevant hemodynamic parameters, allowing the clinician to decide whether or not to proceed with the intervention. The system includes accurate simulation of the effects of gravity, respiration and natural compensatory mechanisms, including the baroreflex. 1. A full-system , cardiovascular simulation and prediction method , comprising:providing a computational device functionally connected to an image display device;providing a hemodynamic simulation software module, operable on said computational device, programmed to provide, cycle by cycle, a real-time, closed-loop, complete body hemodynamic simulation of a patient undergoing a surgical procedure;providing a first, patient specific, parameter file comprising a patent specific general data file and a patient specific hemodynamic data file;calculating, using said computational device, said hemodynamic simulation software module, and said first patent specific parameter file, a first patent parameter status file comprising a first comprehensive cardiovascular status file representative of a first hemodynamic status of said patient's entire circulatory system at a first point in time;simulating a cardiovascular influencing event by providing an event simulating data file;calculating, in real time, a second, undated patent parameter status file, comprising a second comprehensive ...

SYSTEM AND METHOD OF ASSESSING ENDOTHELIAL FUNCTION

A medical diagnostic system and method for assessing endothelial function comprise adjusting a reactive hyperemia indicator, measured in response to a stimulus, based on an anthropomorphic and/or demographic variable. The adjusted reactive hyperemia indicator provides a more accurate reflection of endothelial function and can be communicated to a clinician. 1. A method for assessing endothelial function in a mammal , the method comprising:applying a stimulus to generate reactive hyperemia;measuring a reactive hyperemia indicator;adjusting the reactive hyperemia indicator based on an anthropomorphic and/or demographic variable to arrive at an endothelial function indicator; andcommunicating the endothelial function indicator to a clinician.2. The method of claim 1 , wherein the anthropomorphic or demographic variable comprises a lean body mass of the mammal.3. The method of claim 1 , wherein the reactive hyperemia indicator comprises at least one of a hemodynamic parameter or a temperature.4. The method of claim 3 , wherein the hemodynamic parameter comprises at least one of a volume; a pressure; an amplitude claim 3 , a frequency claim 3 , or a shape of a plethysmographic wave form; a blood vessel diameter; peripheral arterial tone changes; or any derivative thereof.5. The method of claim 3 , wherein the temperature comprises a fingertip temperature.6. The method of claim 1 , wherein the reactive hyperemia indicator comprises a percentage of flow-mediated dilation.7. The method of claim 6 , wherein measuring the percentage of flow-mediated dilation comprises assessing a change in arterial volume of a limb segment of the mammal.8. The method of claim 7 , wherein assessing the change in arterial volume of the limb segment comprises:determining amplitudes of component pulse waves of detected volume pulse waves of the limb segment detected during a baseline period prior to applying the stimulus to determine a baseline arterial volume;determining amplitudes of component ...

Device, system and method for generating biofeedback

An apparatus (10) for generating biofeedback, in particular during a relaxation exercise for lowering blood pressure, comprises at least one interface (12, 13) for receiving a pulse wave signal that represents a pressure pulse or volume pulse of a pulse wave in a blood circulation system as a function of time and an ECG signal. The apparatus (10) comprises an evaluation device (11) that is configured to determine a pulse transit time on the basis of the pulse wave signal and the ECG signal, perform an evaluation of a pulse wave form of the pulse wave signal and generate the biofeedback (31) depending on the pulse transit time and/or the evaluation of the pulse wave form. The apparatus (10) comprises an output interface (14, 30) for providing the biofeedback (31).

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE BLOOD FLOW

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method for processing images to determine cardiovascular information , comprising the steps of:receiving image data including a plurality of coronary arteries originating from an aorta;processing the image data to generate three-dimensional shape models of the coronary arteries;simulating a blood flow for the generated three-dimensional shape models of the coronary arteries; anddetermining a fractional flow reserve (FFR) of the coronary arteries based on a blood flow simulation result, wherein in the step of simulating the blood flow, a computational fluid dynamics model is applied to the three-dimensional shape models of the coronary arteries, a lumped parameter model is combined with the computational fluid dynamics model, and a simplified coronary artery circulation model including coronary arteries, capillaries of the coronary arteries and coronary veins is used as the lumped parameter model.186. The method of claim 185 , wherein claim 185 , when simulating the blood flow claim 185 , when applying the computational fluid dynamics model to the three-dimensional shape models of the coronary arteries claim 185 , using an aorta blood pressure pattern as an inlet boundary condition.187. The method of claim 185 , wherein simulating the blood flow comprises determining lengths of centerlines of the three- ...

IMPLANTABLE MEDICAL DEVICE WITH GYROSCOPE

An implantable medical device (IMD) that includes a housing, a first electrode secured relative to the housing, a second electrode secured relative to the housing, and a gyroscope secured relative to the housing. The IMD may include circuitry in the housing in communication with the first electrode, the second electrode, and the gyroscope. The circuitry may be configured to determine and store a plurality of torsion data measurements, from which a representation of a twist profile may be determined. 1. A leadless cardiac pacemaker (LCP) configured to sense cardiac activity and to pace a patient's heart , the LCP comprising:a housing;an electrode secured relative to the housing and exposed to an environment outside of the housing;a gyroscope disposed relative to the housing; ["pace the patient's heart using the electrode;", "determine a twisting profile of the patient's heart over one or more cardiac cycles based at least in part on data obtained from the gyroscope;", "determine a status of an acute and/or chronic condition of the patient's heart based at least in part on the determined twisting profile; and", "communicate the status of the acute and/or chronic condition of the patient's heart to an external device."], 'circuitry in the housing in communication with the electrode and the gyroscope, the circuitry configured to2. The LCP of claim 1 , wherein the acute and/or chronic condition of the patient's heart comprises a systolic and/or diastolic heart failure condition.3. The LCP of claim 1 , wherein the acute and/or chronic condition of the patient's heart comprises an aortic stenosis condition.4. The LCP of claim 1 , wherein the acute and/or chronic condition of the patient's heart comprises a mitral regurgitation condition.5. The LCP of claim 1 , wherein the acute and/or chronic condition of the patient's heart comprises a transmural infarction condition.6. The LCP of claim 1 , wherein the acute and/or chronic condition of the patient's heart comprises a ...

MULTI-SENSOR PATIENT MONITOR TO DETECT IMPENDING CARDIAC DECOMPENSATION

Systems and methods of detecting an impending cardiac decompensation of a patient measure at least two of an electrocardiogram signal of the patient, a hydration signal of the patient, a respiration signal of the patient or an activity signal of the patient. The at least two of the electrocardiogram signal, the hydration signal, the respiration signal or the activity signal are combined with an algorithm to detect the impending cardiac decompensation. 142-. (canceled)43. A system to predict impending acute cardiac decompensation of a patient , the system comprising:an adherent patch including at least four electrodes connected to the patch and capable of electrically coupling to the patient;impedance circuitry coupled to two or more of the at least four electrodes to measure an impedance associated with the patient;a temperature sensor configured to measure a temperature of a skin of the patient; anda processor system in communication with the impedance circuitry and the temperature sensor, wherein the processor system calculates a hydration measurement based on the measured impedance and corrects the calculated hydration measurement based on the measured skin temperature of the patient, wherein the processor system utilizes the calculated hydration measurement to predict an impending acute cardiac decompensation of the patient.44. The system of claim 43 , wherein the impedance circuitry places a voltage and/or current at one or more of the electrodes having a frequency between 0.5 kHz and about 20 kHz such that the hydration measurement corresponds to the extracellular fluid of the patient.45. The system of claim 43 , wherein the processor system corrects the calculated hydration measurement by lowering the hydration measurement in response to an increase in measured skin temperature.46. The system of claim 45 , wherein the processor system corrects the calculated hydration measurement by increasing the hydration measurement in response to a decrease in the ...

Method and system for estimating momentary cardiovascular performance reserve

The invention relates to a method for determining a cardiovascular performance reserve for each individual patient, comprising the steps of: a) receiving input physiological data from the patient for obtaining a parameter Z which is or approximates the product of the Stroke Volume (SV) by the Systemic Vascular Resistance (SVR); b) providing a value representing the Respiratory Rate (RR) of said patient, wherein the Respiratory Rate (RR) value is provided by measurements using dedicated device(s), calculations from the input physiological data or manually by using best estimate; c) providing anthropometric data of said patient for calculating the Body Surface Area (BSA) of said individual, wherein the anthropometric data includes at least body dimensions (such as height and weight) of said patient; d) calculating the Cardiovascular Reserve (CVR) by using said Z parameter and said RR according to following formula: CVR=(Z/RR); e) calculating a Cardiovascular Reserve Index (CVRI) by standardizing said CVR (by said BSA) and normalizing it to a scale of 1 according to the following formula: CVRI=CVR/(BSA*4); and outputting said Cardiovascular Reserve Index.

FLUID RESPONSIVENESS DETECTION DEVICE AND METHOD

A liquid reactivity detection device and method. The liquid reactivity detection device includes: a breathing signal acquisition module, a hemodynamic signal acquisition module and a liquid reactivity detection module. The breathing signal acquisition module and the hemodynamic signal acquisition module work in cases where the subject is in any one of the following breathing modes: a spontaneous breathing mode, a spontaneous breathing combined with mechanical ventilation mode, and a mechanical ventilation mode. The hemodynamic signal acquisition module is configured to acquire at least one hemodynamic signal of the subject. The breathing signal acquisition module is configured to acquire at least one breathing signal of the subject. The liquid reactivity detection module is configured to determine the liquid reactivity of the subject according to the breathing signal and the hemodynamic signal. 1. A fluid responsiveness detection device , comprising: a breathing signal acquisition module , a hemodynamic signal acquisition module and a fluid responsiveness detection module , wherein the breathing signal acquisition module and the hemodynamic signal acquisition module operate under a breathing mode of a subject being any one of: a spontaneous breathing mode , a spontaneous breathing and machine-controlled breathing mode , or a machine-controlled breathing mode;the hemodynamic signal acquisition module is configured to acquire at least one hemodynamic signal of the subject;the breathing signal acquisition module is configured to obtain at least one breathing signal of the subject, the breathing signal comprising a respiratory cycle; andthe fluid responsiveness detection module is configured to determine the fluid responsiveness of the subject based on the breathing signal and the hemodynamic signal,wherein the fluid responsiveness detection module is further configured to determine a respiratory variation and a hemodynamic variation of the subject based on the ...

AUTOMATED CCHD SCREENING AND DETECTION

Automated critical congenital heart defect (“CCHD”) screening systems and processes are described. A caregiver may be guided to use a single or dual sensor pulse oximeter to obtain pre- and post-ductal blood oxygenation measurements. A delta of the measurements indicates the possible existence or nonexistence of a CCHD. Errors in the measurements are reduced by a configurable measurement confidence threshold based on, for example, a perfusion index. Measurement data may be stored and retrieved from a remote data processing center for repeated screenings. 19-. (canceled)10. A computer-implemented method for determining the existence of a critical congenital heart defect , the computer-implemented method comprising: ["gathering first physiological data from a first site on a patient's body;", "gathering second physiological data from a second site on a patient's body;", 'processing said first physiological data and said second physiological data; and', 'outputting a difference between said first physiological data and said second physiological data, the difference used to determine the existence of a critical congenital heart defect., 'under control of one or more computing devices configured with specific computer executable instructions,'}11. The computer-implemented method of claim 10 , wherein the physiological data includes at least one of: blood oxygenation data claim 10 , plethysmograph data claim 10 , pulse rate data claim 10 , respiration data claim 10 , and perfusion index data.12. The computer-implemented method of claim 10 , wherein the physiological data gathered from the first site comprises a pre-ductal blood oxygen saturation measurement claim 10 , and the physiological data gathered from the second site comprises a post-ductal blood oxygen saturation measurement.13. The computer-implemented method of claim 12 , wherein the difference is the computed average claim 12 , over a period of time claim 12 , of the difference between the pre-ductal blood ...

METHOD OF EKG SIGNAL PROCESSING AND APPARATUS FOR PERFORMING THE METHOD

A method of measuring and analyzing the ultra high frequency EKG is performed by measuring the EKG within the frequency range above 250 Hz with a dynamic range of at least 100 dB. In the UHF EKG signal positions of Rof R wave in QRS complex of EKG are detected on the time axis and the EKG signal is converted to amplitude or power envelopes, the amplitude or power envelopes frequency range is anywhere within the limits from 0.2 Hz to at least 500 Hz. From these envelopes the amplitude and time numerical parameters that describe the myocardium depolarization inhomogeneity and electric myocardium dyssynchrony are determined, and these parameters are used for selecting the patients for multi-chamber stimulators implementation and optimization of their setting. 1. A method of an EKG signal processing , whereina frequency range above the frequency of 250 Hz is selected on the EKG signal in measuring channels,from this component of the EKG signal in the selected frequency range amplitude or power envelopes of the EKG signal are calculated,{'sub': 'm', 'these amplitude or power envelopes of the EKG signal are averaged with respect to Rof R wave position to increase signal-to-noise ratio,'}after which the envelopes of the EKG signal from the individual channels obtained this way are compared on the time axis and the electric dyssynchrony of ventricles in units of time is defined as a difference between the time numerical parameters of envelopes of the selected EKG channels.2. The method of the EKG signal processing according to claim 1 , wherein{'sub': m', 'm, 'a median or mean value in the interval of minimum 100 ms after the Rposition up to 300 ms after the Rposition is subtracted from the averaged amplitude or power envelope of the EKG signal to remove a noise background,'}negative values of the envelopes are set to zero after subtracting the median or the mean value.3. The method of the EKG signal processing according to claim 1 , wherein the amplitude or power envelopes ...

Extracting Ventricular Ejection Fraction from Pressure Sensing Data

A method of and system for determining ventricular ejection fraction of a patient is provided. A pressure sensing device captures pulmonary arterial pressure data for a patient over time. A processing device receives the pressure data, generates a first time-resolved pressure curve, displaces the pressure values of the first time-resolved curve at least one time point and subtracts the displaced pressure values from the received pressure data to form a second time-resolved pressure curve so that the second curve has two or more distinct pulses from which an initial pulse may be isolated and an area may be calculated. The processing device determines an average pressure by averaging the pressure data of the first curve over a cardiac cycle of data; determines a cardiac chamber stroke volume for the patient; and uses the determined cardiac chamber stroke volume and determined average pressure to determine an ejection fraction for the patient. 1. A method of determining ventricular ejection fraction of a patient , the method comprising:by a pressure sensing device, capturing pulmonary arterial pressure data for a patient over a period of time; and receive the pressure data captured by the pressure sensing device;', 'generate a first time-resolved pressure curve that comprises the pressure data;', 'displace the pressure values of the first time-resolved curve at least one time point and subtract the displaced pressure values from the received pressure data to form a second time-resolved pressure curve so that the second time-resolved pressure curve has two or more distinct pulses from which an initial pulse may be isolated and an area may be calculated;', 'determine an average pressure by averaging the pressure data of the first time-resolved pressure curve over a cardiac cycle of data;', 'determine a cardiac chamber stroke volume for the patient;', 'use the determined cardiac chamber stroke volume and determined average pressure to determine an ejection fraction for ...

SYSTEM FOR SALIVA COLLECTION

Disclosed herein are portable handheld devices for saliva collection for daily monitoring of salivary biomarkers of physiological conditions, the device comprising: a handheld handle comprising a saliva collector, the saliva collector comprising: a suction tip; a bi-directional pump electrically configurable for pumping towards two opposite directions; a saliva reservoir; a valve; a water reservoir, the water reservoir comprising an external filling lid; a reversible fluidic connection configurable in a connected and disconnected position; and a base accommodating the handheld handle, the base configurable to fluidly communicate with the handheld handle through at least the reversible fluidic connection, wherein the valve is electrically configured to allow fluid communication directly between at least two selected from: the saliva reservoir, the water reservoir, and the reversible fluidic connection, and wherein the bi-directional pump is electrically configurable to allow fluid communication directly between the suction tip and the saliva reservoir. 139-. (canceled)40. A portable handheld device for tooth brushing and saliva collection for daily monitoring of salivary biomarkers of physiological conditions of a subject , the device comprising: i) a suction tip;', 'ii) a bi-directional pump electrically configurable for pumping towards two opposite directions;', 'iii) a saliva reservoir;', 'iv) a valve;', 'v) a water reservoir, the water reservoir comprising an external filling lid;', 'vi) a reversible fluidic connection configurable in a connected position and a disconnected position; and, 'a) a handheld handle comprising a saliva collector, the saliva collector comprisingb) a base accommodating the handheld handle, the base configurable to fluidly communicate with the handheld handle through at least the reversible fluidic connection, wherein the valve is electrically configured to allow fluid communication directly between at least two elements selected from: ...

SYSTEM AND METHOD FOR DIAGNOSING A FLUID STATUS OF A PATIENT

A system and method for diagnosing a fluid status of a patient includes non-invasively determining a left ventricular pressure of blood within a left ventricle of a heart of the patient. The left ventricular pressure is compared to a predefined pressure value to diagnose the fluid status. 1. A method of diagnosing a fluid status of a patient , the method comprising:non-invasively determining a left ventricular pressure of blood within a left ventricle of a heart of the patient; andcomparing the left ventricular pressure to a predefined pressure value to diagnose the fluid status.2. The method according to claim 1 , wherein the diagnosis of the fluid status is used to determine the health of the patient with respect to at least one of fluid amounts and fluid distributions in the body.3. The method according to claim 1 , wherein the diagnosis of the fluid status is used to identify the existence of at least one of dehydration claim 1 , sepsis claim 1 , pulmonary edema claim 1 , low blood volume claim 1 , and shifts in intravascular fluid volumes.4. The method according to claim 1 , wherein the diagnosis of the fluid status is used to determine that no fluid-related problems exist.5. The method according to claim 1 , wherein non-invasively determining a left ventricular pressure further comprises non-invasively measuring a plurality of cardiac parameters of the patient claim 1 , including a stroke volume of the left ventricle claim 1 , a mitral valve area claim 1 , and a left ventricular diastolic filling time.6. The method according to claim 5 , wherein the cardiac parameters are measured using one of an echocardiogram apparatus claim 5 , a magnetic resonance imaging (MRI) apparatus claim 5 , and a computer aided tomography (CAT) apparatus.10. A fluid status diagnostic system comprising:a sensing unit configured to non-invasively measure a plurality of cardiac parameters associated with a left ventricle of a patient, the cardiac parameters including a mitral valve ...

DIAGNOSTIC ASSISTANCE SYSTEM, DIAGNOSTIC ASSISTANCE METHOD, AND DIAGNOSTIC ASSISTANCE PROGRAM

A diagnostic assistance system is disclosed for assisting in diagnosis of heart failure, the diagnostic assistance system including a data obtaining section configured to obtain measurement data on an amount of congestion in at least a part of a body of a patient and measurement data on a parameter related to a blood flow rate of the patient, and a display control section configured to display, on a display unit, a graph in which a first axis indicates the amount of congestion and a second axis indicates the parameter related to the blood flow rate. The display control section is configured to display, in the graph, a point corresponding to the measurement data on the amount of congestion and the measurement data on the parameter related to the blood flow rate. 1. A diagnostic assistance system for assisting in diagnosis of heart failure , the diagnostic assistance system comprising:a data obtaining section configured to obtain measurement data on an amount of congestion in at least a part of a body of a patient and measurement data on a parameter related to a blood flow rate of the patient;a display control section configured to display, on a display unit, a graph in which a first axis indicates the amount of congestion and a second axis indicates the parameter related to the blood flow rate; andthe display control section is configured to display, in the graph, a point corresponding to the measurement data on the amount of congestion and the measurement data on the parameter related to the blood flow rate.2. The diagnostic assistance system according to claim 1 , whereinthe data obtaining section is configured to obtain the measurement data on the amount of congestion and the measurement data on the parameter related to the blood flow rate in time series; andthe display control section is configured to display, in the graph, points corresponding to the measurement data on the amount of congestion and the measurement data on the parameter related to the blood flow ...

PREDICTIVE WEIGHTING OF HYPOTENSION PROFILING PARAMETERS

A system having a processor obtain a digital hemodynamic data from a hemodynamic sensor, obtain one or more vital sign parameters characterizing vital sign data from the digital hemodynamic data, derive differential parameters based on the one or more vital sign parameters, generate combinatorial parameters using the one or more vital sign parameters and the differential parameters, determine a risk score corresponding to a probability of a future hypotension event for the living subject based on a weighted combination of a plurality of hypotension profiling parameters including the one or more vital sign parameters characterizing vital sign data, the differential parameters and the combinatorial parameters, and invoke a sensory alarm if the risk score satisfies a predetermined risk criterion. 1. A system for monitoring health of a living subject , the system comprising:a hardware unit including a hardware processor, an analog-to-digital converter (ADC), and a system memory;a hypotension prediction software code including a predictive weighting module stored in the system memory;a hemodynamic sensor coupled to the hardware unit; anda sensory alarm; obtain a digital hemodynamic data converted, by the ADC, from a signal received from the hemodynamic sensor;', 'obtain one or more vital sign parameters characterizing vital sign data from the digital hemodynamic data;', 'derive differential parameters based on the one or more vital sign parameters characterizing the vital sign data;', 'generate combinatorial parameters using the one or more vital sign parameters characterizing the vital sign data and the differential parameters;', 'determine, using the predictive weighting module, a risk score corresponding to a probability of a future hypotension event for the living subject based on a weighted combination of a plurality of hypotension profiling parameters including the one or more vital sign parameters characterizing vital sign data, the differential parameters and the ...

WIRELESS STETHOSCOPE AND METHOD OF USE THEREOF

A wireless stethoscope is described, having wireless sensors that are enclosed in disposable pads so that the same pads are not used on more than one patient, preventing cross-infection of patients associated with conventional stethoscopes. The present wireless stethoscope also detects pulmonary sounds and cardiac sounds, allowing the user to monitor one or the other without interference. Also described is a method for diagnosing a pulmonary condition using the wireless stethoscope. 133.-. (canceled)34. A wireless stethoscope system comprising:at least one wireless sensor for monitoring bodily sounds, andat least one receiver for receiving electrical signals transmitted wirelessly from the at least one wireless sensor, wherein the at least one receiver filters the received electrical signals to reduce noise; and a microphone comprising a transducer converting bodily sounds into the electrical signals, wherein the converted bodily sounds include at least one of: pulmonary sounds, cardiac sounds, and digestive sounds, and wherein each of the bodily sounds corresponds to one of multiple wavelength ranges; and', 'a transmitter that wirelessly transmits the electrical signals to the at least one receiver,, 'wherein the at least one wireless sensor comprises 'a filter circuit that reduces back ground noise in the signals received from the wireless sensor.', 'wherein the at least one receiver comprises35. The system of claim 34 , wherein the microphone is a contact microphone comprising a magnetic transducer claim 34 , contact plat claim 34 , and contact pin transferring vibrations to the coil.36. The system of claim 34 , wherein the wireless transmission by the transmitter is selected from the group consisting of radio frequency communication signals claim 34 , infrared communication signals claim 34 , short-wavelength radio transmissions and IEEE 802.15.1 signals.37. The system of claim 34 , wherein the receiver is an electronic device selected from the group consisting ...

SYSTEMS AND METHODS FOR TREATMENT PLANNING BASED ON PLAQUE PROGRESSION AND REGRESSION CURVES

Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving patient-specific data regarding a geometry of the patient's vasculature; creating an anatomic model representing at least a portion of a location of disease in the patient's vasculature based on the received patient-specific data; identifying one or more changes in geometry of the anatomic model based on a modeled progression or regression of disease at the location; calculating one or more values of a blood flow characteristic within the patient's vasculature using a computational model based on the identified one or more changes in geometry of the anatomic model; and generating an electronic graphical display of a relationship between the one or more values of the calculated blood flow characteristic and the identified one or more changes in geometry of the anatomic model. 120-. (canceled)21. A computer-implemented method of evaluating a patient with vascular disease , the method comprising:receiving patient-specific image data regarding a geometry of the patient's vasculature;creating, based on the received patient-specific image data, a patient-specific anatomic model representing a diseased region of the patient's vasculature at a first point of time;computing a characteristic of plaque using one or more image features of the received patient-specific image data;predicting, using the computed characteristic of plaque, a change to a geometric parameter of the diseased region of the patient's vasculature at a second point of time;modifying a geometry of the patient-specific anatomic model to include the predicted change to the geometric parameter of the diseased region at the second point in time; andcomputing a value of a vessel characteristic using the modified patient-specific anatomic model.22. The computer-implemented method of claim 21 ,generating a treatment recommendation or risk assessment based on the computed value of the vessel ...

SYSTEM AND METHODS FOR MANAGING BLOOD LOSS OF A PATIENT

One variation of the method for managing blood loss of a patient includes: receiving an image of a physical sample; extracting a feature from an area of the image corresponding to the physical sample; estimating a blood volume indicator of the physical sample according to the extracted feature; estimating a patient blood loss based on the blood volume indicator; estimating a euvolemic patient hematocrit based on an estimated patient blood volume and the estimated patient blood loss; receiving a measured patient hematocrit; and generating a volemic status indicator based on a comparison between the measured patient hematocrit and the estimated euvolemic patient hematocrit. 117-. (canceled)18. A method for managing blood loss of a patient , comprising:tracking a quantity of a fluid administered to the patient intravenously;receiving an image of a physical sample;extracting a feature from an area of the image correlated with the physical sample;estimating a red blood cell content of the physical sample based on the extracted feature;estimating an extracorporeal blood content of the physical sample based on the estimated red blood cell content of the physical sample; andestimating a hematocrit of the patient based on a previous hematocrit of the patient, the quantity of the fluid administered to the patient, and the estimated extracorporeal blood content of the physical sample.19. The method of claim 18 , wherein tracking the quantity of the fluid administered to the patient intravenously comprises tracking the quantity of a known composition administered to the patient according to a transfusion rate claim 18 , wherein estimating hematocrit of the patient comprises estimating the hematocrit of the patient further based on the known composition of the fluid.20. The method of claim 18 , wherein extracting the feature from the area of the image correlated with the physical sample comprises extracting a subset of pixels from a set of pixels within the area of the image.21. ...

MONITORING CARDIAC BLOOD FLOW BALANCE RELATIONSHIP BETWEEN THE RIGHT AND LEFT HEART CHAMBERS AND CARDIAC REGULATION

A system for measuring of cardiac blood flow balance parameter between the right chamber of the heart and the left chamber of the heart includes a sensor device for measuring one of blood pressure and blood flow rate and blood constituent concentration of a patient so as to generate an arterial pulse signal. A processing unit is responsive to the arterial pulse signal for generating a full arterial pulse signal, an arterio-venous pulse signal, and a balance parameter, including a balance ratio and a balance trend, and a pulse variability parameter. A computational device is responsive to the balance parameter for further generating a set of physiological parameters. A display station device is responsive to the set of physiological parameters from the computational device for displaying meaningful information. 1. A system for measuring of cardiac blood flow balance parameter between the right chamber of the heart and the left chamber of the heart , comprising:sensing means for measuring one of blood pressure and blood flow rate and blood constituent concentration of a patient so as to generate a measured arterial pulse signal;processing means responsive to said arterial pulse signal for generating a full arterial pulse signal, defined as the measured arterial pulse signal substantially without the effect of atrial diastolic blood flow demand;said processing means for subtracting said arterial pulse signal from said full arterial pulse signal so as to generate an arterio-venous pulse signal;said processing means further calculating an area under the curve of said full arterial pulse (FAP) signal, measured by integration over the cardiac cycle, and an area under the curve of said arterio-venous (AV) pulse signal, measured by integration over the same cardiac cycle, and a transfer function relationship using said arterio-venous pulse signal area under the curve and said full arterial pulse signal area under the curve to generate a balance parameter representation; ...

AUTOMATED CONDITION SCREENING AND DETECTION

Embodiments are disclosed that enable an electronic device to instruct as user how to user one or more noninvasive sensors to measure one or more physiological parameters of a patient. In one embodiment, the measured parameters are used to obtain a diagnosis, such as a diagnosis of a critical congenital heart defect. 1. (canceled)2. A system for noninvasively measuring a physiological parameter of a user to facilitate a diagnosis , the system comprising:an electronic device comprising a display, a wireless transceiver, a memory device comprising processor-executable instructions stored thereon, and one or more hardware processors in communication with the display, the wireless transceiver, and the memory device; display, on the display, a request for at least one patient ID associated with a user;', 'receive an input including the at least one patient ID;', 'validate the at least one patient ID;', 'display, on the display, instructions to obtain a first measurement by positioning a first noninvasive sensor at a first measurement site on the user;', 'receive, from the first noninvasive sensor, first signals responsive to a first physiological characteristic of the user;', 'calculate a first measured physiological parameter responsive to the first signals;', 'display, on the display, instructions to obtain a second measurement by positioning a second noninvasive sensor at a second measurement site on the user;', 'receive, from the second noninvasive sensor, second signals responsive to a second physiological characteristic of the user;', 'calculate a second measured physiological parameter of the user responsive to the second signals;', 'display, on the display, the first and second measured physiological parameters;', 'transmit, via the wireless transceiver, at least the first and second measured physiological parameters, in association with the at least one patient ID, over a network to a clinician; and', 'initiate, with the wireless transceiver, a telemedicine ...

SUPPORT TOOL AND BIOLOGICAL INFORMATION ACQUISITION SYSTEM

A support tool is mounted on a finger of a subject on whom a sensor is mounted to support acquisition of biological information. A first support is disposed on a nail side of the subject's finger. A second support is disposed on a ventral side of the subject's finger. The relative position of the second support with respect to the first support does not change. A bag is formed with a material softer than the first support and second support, and is disposed along an inner peripheral face of the first support. A ventilation tube forms a ventilation channel communicating with an inside of the bag. The sensor includes a light emission part and a light reception part. The light emission part is disposed between the subject's finger and the bag. The light reception part is disposed between the subject's finger and the second support. 1. A support tool to be mounted on a finger of a subject on which a sensor is mounted so as to support an acquisition of biological information of the subject , the support tool comprising:a first support to be disposed, when mounted, on a first side of the finger of the subject, the first support comprising an inner peripheral face;a second support to be disposed, when mounted, on a second side of the finger of the subject opposite to the first side, a relative position of the second support with respect to the first support being fixed;a bag made of a material softer than the first support and the second support, the bag being at least partially disposed along the inner peripheral face; anda channel formation part forming a fluid channel communicating with an inside of the bag,wherein the support tool is configured such that, when mounted, the sensor is disposed in a detachable manner at at least one of between the finger of the subject and the bag and between the finger of the subject and the second support.2. The support tool according to claim 1 , wherein the inner peripheral face extends in an arc shape.3. The support tool according to ...

AUTOMATED CCHD SCREENING AND DETECTION

Automated critical congenital heart defect (“CCHD”) screening systems and processes are described. A caregiver may be guided to use a single or dual sensor pulse oximeter to obtain pre- and post-ductal blood oxygenation measurements. A delta of the measurements indicates the possible existence or nonexistence of a CCHD. Errors in the measurements are reduced by a configurable measurement confidence threshold based on, for example, a perfusion index. Measurement data may be stored and retrieved from a remote data processing center for repeated screenings. 1. (canceled)2. A method of determining a likelihood of a critical congenital heart defect using a pulse oximeter , the method comprising:displaying, on a display of a pulse oximeter, instructions to a caregiver to position a noninvasive sensor at a first measurement site on a patient predetermined to be substantially indicative of a pre-ductal blood oxygenation level and not substantially indicative of a post-ductal blood oxygenation level, wherein the noninvasive sensor is configured to output signals responsive to attenuation of light at measurement sites on the patient to the pulse oximeter, wherein the first measurement site is on a first limb of the patient;displaying, on the display of the pulse oximeter, an indication to the caregiver of a success or failure of obtaining a measure of pre-ductal blood oxygenation level at the first measurement site;displaying, on the display of the pulse oximeter, instructions to the caregiver to position the noninvasive sensor at a second measurement site on the patient predetermined to be substantially indicative of a post-ductal blood oxygenation level and not substantially indicative of a pre-ductal blood oxygenation level, wherein the second measurement site is on a second limb of the patient, and wherein the second limb of the patient is different from the first limb of the patient;displaying, on the display of the pulse oximeter, an indication to the caregiver of a ...

APPARATUS AND METHODS FOR OPTIMIZING VOLUME STATUS AND CARDIAC OUTPUT

Systems and methods are provided for optimizing hemodynamics within a patient. Specifically, the system incorporates invasive sensor data (e.g., pressure measurements) combined with mechanisms to dynamically change the loading conditions of the heart and/or heart rate, in order to understand hemodynamic parameters. Computational analyses on dynamic sensor data are used to understand and guide heart rate, filling pressures, and/or volume resuscitation in critically ill patients. By pacing the heart or inducing tricuspid regurgitation, the system may cause dynamic changes in sensor data to understand optimal loading conditions and heart rates. While determining optimal hemodynamic parameters, the system may then automatically optimize the heart rate and/or filling pressures in critically ill patients. 1. A system for monitoring and/or treating a patient , comprising:an elongate member comprising a distal portion designed to be inserted into a patient's heart and advanced into a pulmonary artery of the heart;at least one sensor on the distal portion for measuring blood pressure;an electrode structure on the distal portion carrying one or more electrodes, the electrode structure configured to extend the one or more electrodes outwardly away from the distal portion to contact myocardial tissue for the purposes of sensing and pacing the heart; andan external processor that performs computational analyses on sensed parameters in order to estimate volume responsiveness and/or optimal heart rates.2. The system of claim 1 , further comprising a regurgitation structure on the distal portion comprising a radially expandable portion configured to hold open leaflets of a tricuspid valve of the heart to induce tricuspid regurgitation in a controllable manner.3. The system of claim 2 , further comprising one or more sensors for measuring sensor data corresponding to blood flow through one of a right ventricle or pulmonary artery of the heart.4. The system of claim 3 , wherein the ...

PUMP HOMEOSTASIS INDICATOR (PHI)

A method determining adverse events from operation of an implantable blood pump including calculating a moving average convergence divergence (MACD) based on power consumed by the implantable blood pump to maintain a constant rotational speed of an impeller of the implantable blood pump. An alert is generated when the calculated MACD diverges from a predetermined MACD threshold and a predetermined MACD zero-crossing time threshold. 1. A method of determining adverse events from operation of an implantable blood pump , comprising:calculating a moving average convergence divergence (MACD) based on power consumed by the implantable blood pump to maintain a constant rotational speed of an impeller of the implantable blood pump; andgenerating an alert when the calculated MACD diverges from a predetermined MACD threshold and exceeds a predetermined MACD zero-crossing time threshold.2. The method of claim 1 , wherein calculating the MACD includes calculating a slow moving average (SMA) claim 1 , and wherein the SMA is an average measurement of the power consumed by the implantable blood measured at a predetermined interval for a first predetermined period of time.3. The method of claim 2 , wherein the predetermined interval is 15 minutes.4. The method of claim 2 , wherein the first predetermined period of time is 48 hours.5. The method of claim 4 , wherein calculating the MACD includes calculating a fast moving average (FMA) claim 4 , and wherein the FMA is an average measurement of the power consumed by the implantable blood measured at the predetermined interval for a second predetermined period of time less the first period of time.6. The method of claim 5 , wherein the second predetermined period of time is four hours.7. The method of claim 1 , wherein the predetermined MACD threshold is at least one from the group consisting of a minimum MACD value and a maximum MACD value over a continuous 48 hour period multiplied by 150%.8. The method of claim 1 , wherein the ...

DETECTION OF WORSENING HEART FAILURE EVENTS USING HEART SOUNDS

Systems and methods for detecting events indicative of worsening using heart sounds are disclosed. A system can include a signal sensor circuit to sense a heart sound (HS) signal. The system can detect at least first and different second HS components using the HS signal, and generate respective first and second HS metrics. The system can determine a trend indicator for the first or second HS metric, and selectively generate one or more composite HS metrics using the first and second HS metrics, according to the trend indicator indicating a growing or decay trend. The system can include a heart failure (HF) event detector to produce a HF status using the composite HS metrics, and output an indication of the HF status, or deliver therapy according to the HF status. 1. A system , comprising:a metric generator circuit configured to receive cardiac acceleration information of a patient, and to generate a first signal metric and a different second signal metric using the received cardiac vibration information; anda blending circuit configured to generate a composite metric using (1) a ratio of the second signal metric to the first signal metric or (2) a product of the first and second signal metrics; anda cardiac event detector circuit configured to detect a heart failure (HF) status using a combination of (1) at least one of the first or second signal metric and (2) the composite metric.2. The system of claim 1 , wherein the cardiac acceleration information includes cardiac acceleration information from an accelerometer.3. The system of claim 2 , wherein the first and second signal metrics include respectively first and second heart sound metrics.41234. The system of claim 3 , wherein the first heart sound metric includes an intensity of an S or an S heart sound claim 3 , and the second signal metric includes an intensity of an S or S heart sound.5. The system of claim 1 , wherein the cardiac event detector circuit is configured to:generate the composite metric using ...

MOLECULAR AND CELLULAR IMAGING USING ENGINEERED HEMODYNAMIC RESPONSES

According to some aspects, the invention relates to methods and compositions for evaluation of hemodynamic responses (e.g., using molecular imaging) with high sensitivity. 1. A method for evaluating a tissue in a subject , the method comprising:producing a hemodynamic response in a tissue of a subject by providing an effective amount of a vasoactive agent to the tissue;obtaining an image representation of the tissue; andevaluating the tissue based on a hemodynamic response detected in the image representation.2. The method of claim 1 , wherein the hemodynamic response is produced by providing to the tissue an exogenous vasoactive agent in a submicromolar concentration that is effective for inducing a hemodynamic response in the tissue3. The method of claim 1 , wherein the vasoactive agent is provided to the tissue by administering the vasoactive agent to the subject.421-. (canceled)22. The method of claim 1 , wherein the hemodynamic response comprises a change in blood volume in the tissue.23. The method of claim 1 , wherein the hemodynamic response comprises an increase in blood flow in the tissue.24. The method of claim 1 , wherein the hemodynamic response comprises a decrease in blood flow in the tissue.25. The method of claim 1 , wherein the hemodynamic response comprises changes in oxy/deoxyhemoglobin balance in the tissue.26. The method of claim 1 , wherein the tissue is neuronal tissue and wherein the hemodynamic response is associated with changes in neural activity.27. The method of further comprising determining that the hemodynamic response is associated with excitatory neural activity in the tissue.28. The method of further comprising determining that the hemodynamic response is associated with inhibitory activity in the tissue.29. The method of claim 1 , wherein the vasoactive agent is a molecule having the formula X-L-X-L-X claim 1 , in which Xis a blocking domain and/or ligand binding domain claim 1 , Land Lare independently linkers or absent claim 1 ...

Evaluating the Cardiac Engine

The present invention relates to computer-based methods for evaluating an individual's cardiovascular system and computer systems for use in such methods. The computer system recognizes a portion of the individual's cardiovascular system though an imaging device input, then assesses the cardiac power, energy and efficiency during the cardiac cycle. The computer system evaluates circulatory motion and properties of circulatory fluid, and further optimizes the cardiovascular analysis through suggested repositioning of the imaging device. 1. A computer system for evaluating an individual's cardiovascular system , the system comprising:a recognition module configured to recognize a portion of an individual's cardiovascular system;a geometry module coupled to the recognition module and configured to assess a dimensional geometry, physiology, or a combination thereof of the recognized portion of the individual's cardiovascular system at a cardiac cycle time t;an interval selection module configured to select a cardiac cycle interval as a function of cardiac cycle time t;an interval evaluation module responsive to the geometry module's assessment of the recognized portion of the individual's cardiovascular system and configured to compute current, cardiac power, cardiac energy, cardiac efficiency, or a combination thereof of the individual's cardiovascular system at the selected cardiac cycle interval, cardiac cycle time t, or a combination thereof, wherein the interval evaluation module indicates an evaluation of cardiac energy and cardiac efficiency;a flux state module configured to evaluate inductive flux state λ of the individual's cardiovascular system at the cardiac cycle time t; anda magnetic permeability module configured to compute magnetic permeability at the cardiac cycle time t;wherein the inductive λ and μ are used to refine computation of current, cardiac power, cardiac energy, cardiac efficiency, or a combination thereof.2. The computer system of claim 1 , ...

INTRINSIC FREQUENCY ANALYSIS FOR LEFT VENTRICLE EJECTION FRACTION OR STROKE VOLUME DETERMINATION

Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. Together with associated notch timing, heart rate and blood pressure values left ventricle ejection fraction and/or stroke volume can be determination. 1. A system for acquiring and analyzing a hemodynamic waveform of a subject by Intrinsic Frequency (IF) analysis , the system comprising:a scanner adapted to capture a signal corresponding to a hemodynamic waveform; and{'sub': 1', '2', '1', '1', '2', '2, 'at least one computer processor connected to the scanner by a wired or wireless connection, wherein the computer processor is adapted to receive the signal for the hemodynamic waveform, determine a Dicrotic Notch using the signal, calculate first and second intrinsic frequencies (ω, ω) on each side of the Dicrotic Notch and at least one of other IF parameters including a, b, a, b, and c for the waveform, and output a signal corresponding to at least one of left ventricle ejection fraction (LVEF) and stroke volume (SV).'}2. The system of claim 1 , wherein LVEF is calculated as a function of the IF parameters and p claim 1 , p claim 1 , p claim 1 , Tand HR.3. The system of claim 1 , wherein SV is calculated as a function of the IF parameters and p claim 1 , p claim 1 , p claim 1 , Tand HR.4. A computer readable medium having stored thereon instructions claim 1 , which when executed cause one or more processors to:determine a Dicrotic Notch using an input signal corresponding to a hemodynamic waveform;{'sub': 1', '2', '1', '1', '2', '2, 'calculate, by Intrinsic Frequency (IF) analysis, first and second intrinsic frequencies (ω, ω) on each side of the Dicrotic Notch and at least one of other IF parameters including a, b, a, b, c for the hemodynamic waveform; and'}output a signal corresponding to at least ...

ESTIMATE DIASTOLIC PRESSURE

This document discusses, among other things, systems and methods to estimate an arterial diastolic pressure of a patient using ventricular pressure information of a heart of the patient and heart sound information of the heart of the patient, such as a timing of at least one of a first heart sound (S) or a second heat sound (S), in certain examples, adjusted by a respective correction factor. 1. A system , comprising:a pressure signal input circuit configured to receive ventricular pressure information of a heart of a patient;a heart sound signal input circuit configured to receive heart sound information of the heart of the patient; andan arterial diastolic pressure circuit configured to estimate an arterial diastolic pressure of the patient using the ventricular pressure information and the heart sound information of the heart.212. The system of claim 1 , wherein the heart sound information includes a timing of at least one of a first heart sound (S) or a second heart sound (S) claim 1 , and{'b': 1', '2, 'wherein the arterial diastolic pressure circuit is configured to estimate the arterial diastolic pressure of the patient using the ventricular pressure information and the timing of at least one of the S or the S.'}3. The system of claim 2 , wherein the ventricular pressure information of the heart of the patient includes a ventricular pressure signal of a ventricle of the heart over a first time interval claim 2 ,{'b': '2', 'wherein the heart sound information includes a timing of the S in the first time interval, and'}{'b': '2', 'wherein the arterial diastolic pressure circuit is configured to estimate the arterial diastolic pressure of the patient using a measurement of the ventricular pressure signal at the time of the S.'}4. The system of claim 2 , wherein the ventricular pressure information of the heart of the patient includes a ventricular pressure signal of a ventricle of the heart over a first time interval claim 2 ,{'b': '2', 'wherein the heart sound ...

INTRINSIC FREQUENCY ANALYSIS FOR LEFT VENTRICLE EJECTION FRACTION OR STROKE VOLUME DETERMINATION

Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. Together with associated notch timing, heart rate and blood pressure values left ventricle ejection fraction and/or stroke volume can be determination. 111-. (canceled)12. A system for acquiring and analyzing a hemodynamic waveform , the system comprising:a light source to illuminate an area on a patient's skin;an optical sensor to determine a skin motion waveform at the area of the patient's skin illuminated by the light source; anda processor programmed to determine first and second intrinsic frequencies (IF) based on the measured skin motion waveform and to output a signal corresponding to at least one of left ventricle ejection fraction (LVEF) and stroke volume (SV) based on the determined first and second intrinsic frequencies.13. The system of claim 12 , wherein the first and second intrinsic frequencies are determined using a pre-determined ejection fraction echo versus ejection fraction intrinsic frequency relationship.14. The system of claim 12 , wherein the LVEF is calculated as a function of p claim 12 , p claim 12 , p claim 12 , Tand heart rate claim 12 , wherein p claim 12 , p claim 12 , pare minimum claim 12 , maximum claim 12 , and mean systolic pressures claim 12 , respectively claim 12 , and Tis an ejection time of the left ventricle.15. The system of claim 12 , wherein SV is calculated as a function of p claim 12 , p claim 12 , p claim 12 , Tand heart rate claim 12 , wherein p claim 12 , p claim 12 , pare minimum claim 12 , maximum claim 12 , and mean systolic pressures claim 12 , respectively claim 12 , and Tis an ejection time of the left ventricle.16. The system of claim 12 , wherein the light source is a smartphone light.17. The system of claim 12 , wherein the optical sensor is a ...

PRESSURE SENSOR TO DETECT BODY SOUNDS

This document discusses, among other things, using a pressure sensor to detect body sound information of a patient, such as cardiac murmurs, respiratory sounds, etc. 1. A system , comprising:a pressure sensor configured to receive physiologic information from a patient; and a low-frequency data processing circuit configured to detect pressure information from the patient using the physiologic information received by the pressure sensor when the control signal is in a first state; and', 'a high-frequency data processing circuit configured to detect body sound information from the patient using the physiologic information received by the pressure sensor when the control signal is in a second state., 'a control circuit, coupled to the pressure sensor, configured to receive information from the pressure sensor, and to provide a control signal to the pressure sensor, wherein the control circuit includes2. The system of claim 1 , including a leadless cardiac pacemaker (LCP) claim 1 , wherein the LCP includes the pressure sensor having a deformable element claim 1 , 'an anchor to secure the LCP in an atrium or a ventricle of a heart of the patient; and', 'wherein the LCP includesfirst and second electrodes configured to detect electrical information of the heart.3. The system of claim 1 , wherein the LCP includes:an anchor configured to secure the LCP to an interior wall of a left ventricle of a heart; andfirst and second electrodes configured to detect electrical information of the heart.4. The system of claim 3 , wherein the control circuit is configured to provide the control signal in response to the detected electrical information.5. The system of claim 1 , wherein the control circuit is configured to provide the control signal in response to the received physiologic information from the pressure sensor.6. The system of claim 5 , wherein the control circuit is configured to detect diastole in the patient using information from the pressure sensor claim 5 , andwherein ...

Method and processing device for assessing volume responsiveness

The present invention belongs to the field of medicine and discloses a method for assessing volume responsiveness and a processing device for assessing volume responsiveness. The method comprises: acquiring, by using one or more vibration sensitive sensors, a first parameter associated with a change in preload in a first time interval before a subject performs a passive straight-leg lift in a passive leg raising (PLR) test; acquiring, by using the one or more vibration sensitive sensors, a second parameter associated with a change in preload in a second time interval after the subject performs a passive straight-leg lift in the PLR test; and determining the volume responsiveness of the subject according to the first parameter associated with a change in preload and the second parameter associated with a change in preload. The method provides a convenient and easy determination of volume responsiveness.

SYSTEM AND METHOD FOR NON-INVASIVE MONITORING OF HEMATOCRIT CONCENTRATION

A method of non-invasively monitoring hematocrit levels includes monitoring a first emission response to the light provided at the first excitation wavelength, wherein the first emission response is monitored at a first wavelength and monitoring a second emission response to the light provided at the first excitation wavelength, wherein the second emission response is monitored at a second wavelength. A ratiometric value is calculated based on a ratio of the first emission response to the second emission response, wherein the ratiometric value corresponds with hematocrit level of the patient. 1. A system for non-invasive monitoring of hematocrit levels of a patient , the system comprising:a medical device comprising:at least one light emitter configured to provide a first excitation signal to patient tissue at a first wavelength selected to generate an emission response for a selected blood component;at least two photodetectors configured to monitor amplitudes of an emission response at a first emission wavelength and at a second emission wavelength, wherein the first emission wavelength is selected to correspond with a maximum of the emission response and the second emission wavelength is selected to correspond with a minimum of the emission response; anda processing module configured to receive emission response amplitudes measured at the first emission wavelength and the second emission wavelength, wherein the processing module calculates a ratiometric value based on the received emission responses and utilizes the calculated ratiometric value to determine the hematocrit level.2. The system of claim 1 , wherein the processing module calculates an initial ratiometric value representative of an initial hematocrit level claim 1 , and associates the initial ratiometric value with a known hematocrit level of the patient.3. The system of claim 2 , wherein the processing module calculates a subsequent ratiometric value and compares the initial ratiometric value to the ...

SYSTEM AND METHOD FOR OBTAINING BODILY FUNCTION MEASUREMENTS USING A MOBILE DEVICE

Methods, systems, computer-readable media, and apparatuses for obtaining at least one bodily function measurement are presented. A mobile device includes an outer body sized to be portable for user, a processor contained within the outer body, and a plurality of sensors physically coupled to the outer body. The sensors are configured to obtain a first measurement indicative of blood volume and a second measurement indicative of heart electrical activity in response to a user action. A blood pressure measurement is determined based on the first measurement and the second measurement. The sensors also include electrodes where a portion of a user's body positioned between the electrodes completes a circuit and a measurement to provide at least one measure of impedance associated with the user's body. A hydration level measurement is determined based on the measure of impedance. 1. A mobile device for obtaining at least one bodily function measurement , comprising:an outer body sized to be portable for a user;a plurality of sensors physically coupled to the outer body, a first sensor of the plurality of sensors comprising a first electrode coupled to the outer body; anda multifunction contact button comprising a second electrode of the first sensor, wherein the multifunction contact button coupled to the outer body and configured to receive user input to interact with the mobile device, used to obtain a ECG measurement or combination thereof,a processor contained within the outer body and coupled to the plurality of sensors, the processor configured to, in response to the mobile device transitioning into a measurement mode, obtain the ECG measurement based on signals received from the first electrode and the second electrode.2. The mobile device of claim 1 , wherein the processor configured to obtain the ECG measurement comprises the processor configured to:measure electrical impulses received by the first electrode and the second electrode; anddetermine the ECG ...

SYSTEM AND METHOD OF DETERMINING A SUSCEPTIBILITY TO CARDIORESPIRATORY INSUFFICIENCY

A system and method for determining a patient's susceptibility to develop cardiorespiratory instability wherein physiological parameters are analyzed with respect to a dynamics systems model to produce and indicator associated with a probability that the patient will become unstable is provided. 1. A method for determining the susceptibility of a patient to develop cardiorespiratory instability relating to one or more physiological parameters , the method comprising:monitoring one or more physiological parameters associated with the patient;accessing, via one or more processors, a dynamics systems model directed to predicting a patient's likelihood of developing cardiorespiratory instability from patient data that includes measurements of the one or more physiological parameters;comparing, via the one or more processors, measurements of at least one of the monitored one or more physiological parameters from the patient with the dynamics systems model;determining, via the one or more processors, a susceptibility of the patient to develop cardiorespiratory instability; and,indicating, via the one or more processors, the susceptibility of the patient to develop cardiorespiratory instability.2. The method of claim 1 , further comprising generating a report indicating the susceptibility of the patient to develop cardiorespiratory instability.3. The method of claim 1 , wherein the susceptibility comprises a susceptibility to develop cardiorespiratory instability between 0 and 30 minutes in the future.4. The method of claim 3 , wherein the susceptibility is indicated as a likelihood of developing at least one condition selected from hypovolemic claim 3 , cardiogenic claim 3 , or vasomotor tone dysfunction between 5 and 15 minutes in the future.5. The method of further including proposing claim 1 , via the one or more processors claim 1 , an additional physiological parameter of the patient to be monitored and a corresponding effect such monitoring would have on the ...

Differentiating decompensation detection based on co-morbidities in heart failure

This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.

SENSOR-BASED PAIN MANAGEMENT SYSTEMS AND METHODS

This document discusses, among other things, systems and methods for managing pain of a subject. A system includes a first sensor circuit to sense a first signal indicative of a functional state of the subject, a second sensor circuit to sense a second signal different from the first signal, and a controller circuit. The controller circuit may determine an operating mode of the second sensor circuit according to the sensed first signal, trigger the second sensor circuit to sense the second signal under the determined operating mode, and generate a pain score using at least the second signal sensed under the determined operating mode. The pain score may be output to a patient or used for closed-loop control of a pain therapy. 1. A system for managing pain of a patient , the system comprising:a first sensor circuit configured to sense from the patient a first signal indicative of a functional state of the patient;a second sensor circuit configured to sense from the patient a second signal different from the first signal; and determine an operating mode of the second sensor circuit using the sensed first signal;', 'trigger the second sensor circuit to sense the second signal under the determined operating mode;', 'generate a pain score using at least the second signal sensed under the determined operating mode; and', 'output the pain score to a user or a process., 'a controller circuit configured to2. The system of claim 1 , further comprising an electrostimulator coupled to the controller circuit and configured to generate electrostimulation energy to treat pain claim 1 ,wherein the controller circuit is further configured to control the electrostimulator to deliver a pain therapy and to control the electrostimulation energy generated by the electrostimulator according to the pain score.3. The system of claim 2 , wherein the electrostimulator is further configured to deliver at least one of:a spinal cord stimulation;a brain stimulation; ora peripheral nerve ...

SYSTEM AND METHOD FOR MONITORING CARDIAC OUTPUT, FLOW BALANCE, AND PERFORMANCE PARAMETERS

A system for measuring of cardiac output and cardiac performance parameters based on a cardiac blood flow balance parameter between a right chamber of the heart and a left chamber of the heart, includes a sensor device for measuring one of blood pressure and blood flow rate and blood constituent concentration of a patient so as to generate an arterial pulse signal. A processing unit is responsive to the arterial pulse signal for generating a full arterial pulse signal, an arterio-venous pulse signal, and a balance parameter. A computational device is responsive to the balance parameter for further generating cardiac output and a set of cardiac performance parameters. A display station device is responsive to the set of physiological parameters from the computational device for displaying meaningful information. 1. A method for determining cardiac performance parameters so as to assess a patient's health condition , comprising the processing steps of:measuring of one of an aortic pressure signal and a pulmonary arterial pressure signal;measuring of an electrocardiogram or electrogram waveform signal;computing of a first derivative of the measured aortic or pulmonary arterial pressure signal;determine a heart valve opening event using the maximum peak of the first derivative of the measured aortic or pulmonary arterial pressure signal;determine a heart valve closing event using the minimum valley of the first derivative of the measured aortic or pulmonary arterial pressure signal;optionally determine an end systolic pressure event and value using the maximum of the measured one of aortic pressure, pulmonary arterial pressure, and ventricular pressure signal;calculating a full arterial pulse waveform signal from the said measured aortic or pulmonary arterial pressure signal, defined as the aortic or pulmonary artery pressure signal without the effect of atrial diastolic blood flow demand;calculating an arterio-venous pulse waveform signal by the subtraction of the said ...

NON-INVASIVE HEMODYNAMIC ASSESSMENT VIA INTERROGATION OF BIOLOGICAL TISSUE USING A COHERENT LIGHT SOURCE

Systems and methods are disclosed for determining physiological information in a subject. The system includes; a light source positionable along a first location outside of the subject; a photo-sensitive detector positionable along a second location outside of the subject and configured to detect scattered light and generate a signal; a processor having a program and a memory, wherein the processor is operably coupled to the detector and configured to receive and store the signals generated over a period of time; wherein the processor is programmed to derive contrast metrics from the stored signals, calculate a waveform from the contrast metrics, decompose the waveform into basis functions and respective amplitudes, and compare the basis function amplitudes to determine the physiological information. 1. A system for determining one or more physiological parameters in a subject , the system comprising:a. a light source positionable along a first location outside of the subject, and configured to direct light from the first location toward a plurality of particles flowing in pulsatile motion within a blood vessel inside of the subject;b. a photo-sensitive detector positionable along a second location outside of the subject, and configured to detect light from the plurality of particles and generate a raw signal in response to the detected light, wherein the detected light includes the light scattered and absorbed by the plurality of particles; and wherein the processor is programmed to:', 'i. derive contrast metrics and intensity metrics from the raw signal;', 'wherein the first waveform comprises a flow data wavefo and the second waveform comprises a volume data waveform;', 'ii. calculate the first waveform from the contrast metrics and the second waveform from the intensity metrics;'}, 'iii. decompose the first waveform and the second waveform into corresponding one or more characteristic features; and', 'iv. make a comparison of the corresponding one or more ...

Capillary Refill Measurement

A capillary refill measurement apparatus (), comprising a support element () configured to receive the weight of a user through their foot, a light source () for illuminating a region of the foot that exerts weight onto the support element (), a light detector () arranged to receive light from the illuminated region () of the foot and generate an output based on the received light, and a processor () configured to determine a capillary refill rate from the output of the light detector () when the user adjusts the amount of weight received by the support element (). 1. A capillary refill measurement apparatus , comprisinga support element configured to receive the weight of a user through their foot,a light source for illuminating a region of the foot that exerts weight onto the support element,a light detector arranged to receive light from the illuminated region of the foot and generate an output based on the received light, anda processor configured to determine a capillary refill rate from the output of the light detector when the user adjusts the amount of weight received by the support element.2. The apparatus of claim 1 , further comprising a force or pressure transducer claim 1 , configured to provide an output based on the amount of weight received by the support element.3. The apparatus of claim 2 , wherein the pressure transducer comprises an electrically conductive woven or knitted fabric that changes impedance in response to pressure.4. The apparatus of claim 1 , further comprising a temperature sensor configured to provide an output related to the temperature of the foot claim 1 , when the apparatus is in use.5. The apparatus of claim 1 , wherein the processor is configured to be responsive to at least one of a pressure on the support element and the temperature of the foot claim 1 , when determining a capillary refill rate.6. The apparatus of claim 1 , comprising an illumination optical fibre for directing light from the light source to the illuminated ...

NON-INVASIVE BLOOD PRESSURE MEASUREMENT SYSTEM

A system for non-invasively determining an indication of an individual's blood pressure is described. In certain embodiments, the system calculates pulse wave transit time using two acoustic sensors. The system can include a first acoustic sensor configured to monitor heart sounds of the patient corresponding to ventricular systole and diastole and a second acoustic sensor configured to monitor arterial pulse sounds at an arterial location remote from the heart. The system can advantageously calculate a arterial pulse wave transit time (PWTT) that does not include the pre-ejection period time delay. In certain embodiments, the system further includes a processor that calculates the arterial PWTT obtained from the acoustic sensors. The system can use this arterial PWTT to determine whether to trigger an occlusive cuff measurement. 18.-. (canceled)9. A system for monitoring blood pressure of a patient , the system comprising: receive an electrocardiograph (ECG) signal from an ECG sensor coupled with a patient,', "receive a cardiac ejection signal from a second sensor coupled with the patient, the cardiac ejection signal configured to reflect ejection of blood from the patient's heart,", 'receive a pulse signal from an acoustic sensor coupled with a limb of the patient, and', 'determine an arterial pulse wave transit time (PWTT) based at least partly on the ECG signal, the cardiac ejection signal, and the pulse signal; and, 'a blood pressure analyzer comprising one or more processors, the blood pressure analyzer configured toa non-invasive blood pressure module configured to trigger an occlusive blood pressure cuff to obtain a blood pressure measurement from the patient responsive to a change in the arterial PWTT.10. The system of claim 9 , wherein the cardiac ejection signal comprises an acoustic signal responsive to a heart sound of the patient's heart.1115.-. (canceled)16. The system of claim 9 , wherein the blood pressure analyzer is configured to determine the ...

Methods and Apparatus for Determining Central Venous Pressure

Described herein is a venous pressure monitoring system which is configured to determine central venous pressure based on jugular venous pressure. One embodiment of the JVP monitoring system may include at least one signal processor, at least one accelerometer, at least one memory 5 for storing computer instructions related to the processor(s) and/or accelerometer(s), at least one display, and at least one patch adapted to be held in place or otherwise secured to a patients neck. The signal processor may be in communication with the accelerometer(s) to translate the output from the accelerometer(s) to yield a signal and calculate the central venous pressure. 1. An apparatus for monitoring venous pressure , comprising:one or more accelerometers each mounted upon one or more corresponding tabs which are positionable upon a skin of a patient and in proximity to an underlying vessel, wherein each tab is in a fixed arrangement with respect to one another and each tab is independently movable relative to an adjacent tab;a platform in communication with the one or more accelerometers; anda processor in communication with each of the one or more accelerometers, wherein the processor is programmed to monitor a position of a pulse height within the underlying vessel via movement of skin with the one or more accelerometers and determine a corresponding venous pressure.2. The apparatus of wherein the platform is configured for placement upon the skin and is comprised of a flexible material which conforms to contours of a neck of the patient.3. The apparatus of wherein the tabs are configured for placement upon the skin of a neck of the patient in proximity to an internal jugular vein.4. The apparatus of wherein the platform comprises a circuit board and the one or more corresponding tabs are isolated from one another via spaces or cutouts.5. The apparatus of wherein the one or more tabs are attached to the platform via corresponding necks or wires each having a flexibility ...

System and Method for Determining Arterial Compliance and Stiffness

A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject's heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject's heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.

AUTOMATED BLOOD PRESSURE MEASUREMENT SYSTEM

A non-invasive blood pressure measurement system is disclosed. The system can include a processing unit, a non-invasive blood pressure (NIBP) sensor, a first altitude sensor and a second altitude sensor. The NIBP sensor can be configured to transmit a blood pressure signal to the processing unit. The first and second altitude sensors can be configured to generate and transmit first and second height measurements, respectively. The processing unit can be configured to generate an adjusted blood pressure measurement using the first height measurement, which can be the height of a patient's heart, and the second height measurement, which can be the height of the NIBP sensor. Methods for determining the blood pressure of a patient using the system are also disclosed. 1. A non-invasive blood pressure measurement system , comprising:a processing unit;a non-invasive blood pressure sensor configured to transmit a blood pressure signal to the processing unit;a first altitude sensor configured to generate a first height measurement and transmit the first height measurement to the processing unit; anda second altitude sensor configured to generate a second height measurement and transmit the first height measurement to the processing unit;wherein the processing unit is configured to generate an adjusted blood pressure measurement using the first height measurement, the second height measurement and the blood pressure signal.2. The non-invasive blood pressure measurement system of claim 1 , wherein the non-invasive blood pressure sensor is a cuff including a pressure interface opening claim 1 , and wherein the first altitude sensor is positioned at the cuff.3. The non-invasive blood pressure measurement system of claim 2 , wherein the processing unit is configured to calculate the adjusted blood pressure measurement after receiving both the first and the second height measurements.4. The non-invasive blood pressure measurement system of claim 1 , further comprising a display ...

HEART VALVE PROSTHESIS WITH INTEGRATED ELECTRONIC CIRCUIT FOR MEASURING INTRAVALVULAR ELECTRICAL IMPEDANCE, AND SYSTEM FOR MONITORING FUNCTIONALITY OF THE PROSTHESIS

A heart valve prosthesis of any type, with internal microelectronic circuit for monitoring the movement of the valve leaflets or of the movable opening and closing elements of said heart valve prosthesis, and external electronic system for telemetric monitoring of such a sensorized heart valve prosthesis, characterized in that said heart valve prosthesis comprises two or more electrodes set in the annular base body of the prosthesis itself, and comprises an internal microelectronic circuit, which is connected to electric power supply means, is equipped with means for generating, between said electrodes, an electrical field, the field lines of which are oriented so as to interfere with the opening and closing movement of the movable elements of said heart valve prosthesis or of the natural leaflets of the heart valve on which said prosthesis will be mounted, and is equipped with or connected to means for detecting the variations of said electrical field produced by the cyclic movement of opening or closing of said leaflets or of said movable elements, which will be expressed as variations of intravalvular electrical impedance and characterized in that it comprises, implanted, a transceiver unit with corresponding antenna for telemetric transmission of the data correlated to said variations of intravalvular electrical impedance, to an external unit that processes the collected data and uses them at least for purposes of diagnosis and prevention. 1. A heart valve prosthesis of any type , with internal microelectronic circuit for monitoring the motion of the natural valve leaflets or of the artificial opening and closing elements of the heart valve prosthesis , and external electronic system for telemetric monitoring of such a sensorized heart valve prosthesis , characterized in that the heart valve prosthesis comprises two or more electrodes set in the annular base body , of the prosthesis itself , and comprises an internal microelectronic circuit , which is connected ...

System and Method for Mapping Patient Data from One Physiological State to Another Physiological State

Systems and methods for determining a quantity of interest of a patient comprise receiving patient data of the patient at a first physiological state. A value of a quantity of interest of the patient at the first physiological state is determined based on the patient data. The quantity of interest represents a medical characteristic of the patient. Features are extracted from the patient data, wherein the features which are extracted are based on the quantity of interest to be determined for the patient at a second physiological state. The value of the quantity of interest of the patient at the first physiological state is mapped to a value of the quantity of interest of the patient at the second physiological state based on the extracted features. 1. A method for determining a quantity of interest of a patient , comprising:receiving patient data of the patient at a first physiological state;determining a value of a quantity of interest of the patient at the first physiological state based on the patient data, the quantity of interest representing a medical characteristic of the patient;extracting features from the patient data, wherein the features which are extracted are based on the quantity of interest to be determined for the patient at a second physiological state; andmapping the value of the quantity of interest of the patient at the first physiological state to a value of the quantity of interest of the patient at the second physiological state based on the extracted features.2. The method as recited in claim 1 , wherein mapping the value of the quantity of interest of the patient at the first physiological state to the value of the quantity of interest of the patient at the second physiological state further comprises:mapping the value of the quantity of interest of the patient at the first physiological state to the value of the quantity of interest of the patient at the second physiological state without using data of the patient at the second ...

BLOOD WITHDRAWAL CANNULA OF A PUMP REPLACING OR ASSISTING ACTIVITY OF THE HEART

The invention relates to a blood withdrawal cannula () for connecting a pump () assisting or replacing activity of the heart to the inner volume of a heart ventricle (), in particular the left ventricle. At the end thereof that is located in the ventricle the cannula has a pressure sensor () for measuring the ventricle pressure and/or ventricle pressure differences and at the same end of the cannula has a volume sensor () for measuring the volume and/or volume changes of the ventricle () in at least a partial region of the ventricle. The invention further relates to a measuring device for monitoring the ventricle contractions and/or the function of a pump replacing or assisting activity of the heart. The measuring device can be/is connected to the pressure sensor () and to the volume sensor of a blood withdrawal cannula according to any one of the preceding claims and is designed to detect pressure changes and volume changes of a ventricle () as the heart is beating. 1. A blood-drawing cannula for connecting a pump assisting or replacing cardiac action to the chamber of the left ventricle , with , at the end of the cannula inside the ventricle , a pressure sensor for measuring the ventricle pressure and/or ventricle pressure differences , wherein the cannula has a volume sensor at the same cannula end for measuring the volume and/or volume changes of the ventricle in at least a part of the ventricle.2. The blood-drawing cannula according to claim 1 , wherein the volume sensor is configured as a pin that extends claim 1 , facing away from the cannula end claim 1 , particularly into the chamber of the ventricle claim 1 , and includes two spaced electrodes that are mounted on the surface thereof by means of which claim 1 , due to the application of a potential difference claim 1 , a current flow can be generated through the blood of the ventricle claim 1 , and the pin includes at least two sensing electrodes that are provided between these electrodes by which a drop in ...

System and method for monitoring arterial and venous blood oxygen, blood glucose, and blood constituent concentration

A system for measuring of arterial and venous blood constituent concentration based first on measuring cardiac blood flow balance parameter between the right chamber of the heart and the left chamber of the heart, which includes a sensor device for measuring one of blood pressure and blood flow rate and blood constituent concentration of a patient so as to generate an arterial pulse signal. A processing unit is responsive to the arterial pulse signal for generating full arterial pulse plethysmography waveforms, arterio-venous pulse plethysmography waveforms, and balance parameters. A computational device that is responsive to plethysmography waveforms generating a plurality of state space linear transfer functions by applying system identification between plethysmography waveforms at various wavelengths representing a plurality of models of the blood constituent concentration, including oxygen, carbon dioxide, hemoglobin, and glucose, and displaying related useful information.

METHOD AND SYSTEM FOR DETECTING CARDIAC TAMPONADE IN A PATIENT

System for indicating a possibility a cardiac tamponade occurring in a patient, comprising: —a right atrium pressure sensor, configured for measuring a right atrium pressure in a right atrium of the patient; —an intra pericardial pressure sensor, configured for measuring an intra pericardial pressure in a portion of an intra-pericardial space of the patient; —a processing device that is operatively connected to the pressure sensors, is provided with a predetermined statistical distribution of pressure versus tamponade probabilities, and is configured for: —determining a trans-mural pressure difference between the right atrium pressure and the intra pericardial pressure; —comparing the trans-mural pressure difference with the statistical distribution, and —indicating the possibility of cardiac tamponade occurrence, based on the trans-mural pressure difference comparison. 1. A system for indicating an occurrence probability for cardiac tamponade in a patient , the system comprising:a right atrium pressure sensor, configured for measuring a right atrium pressure in a right atrium of the patient;an intra pericardial pressure sensor, configured for measuring an intra pericardial pressure in a portion of an intra-pericardial space of the patient;a processing device that is operatively connected to the pressure sensors, and that is provided with a predetermined statistical distribution of pressure versus tamponade probabilities, the processing device being configured for:determining a trans-mural pressure difference between the right atrium pressure and the intra pericardial pressure;comparing the trans-mural pressure difference with the statistical distribution, andindicating the occurrence probability, based on the trans-mural pressure difference comparison.2. The system according to claim 1 , comprising:a reference pressure sensor, configured for measuring a reference pressure at a reference location outside the right atrium and the intra-pericardial space, wherein the ...